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2. Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment

Author

Abu-Shawareb, H, Acree, R, Adams, P, Adams, J, Addis, B, Aden, R, Adrian, P, Afeyan, BB, Aggleton, M, Aghaian, L, Aguirre, A, Aikens, D, Akre, J, Albert, F, Albrecht, M, Albright, BJ, Albritton, J, Alcala, J, Alday, C, Alessi, DA, Alexander, N, Alfonso, J, Alfonso, N, Alger, E, Ali, SJ, Ali, ZA, Alley, WE, Amala, P, Amendt, PA, Amick, P, Ammula, S, Amorin, C, Ampleford, DJ, Anderson, RW, Anklam, T, Antipa, N, Appelbe, B, Aracne-Ruddle, C, Araya, E, Arend, M, Arnold, P, Arnold, T, Asay, J, Atherton, LJ, Atkinson, D, Atkinson, R, Auerbach, JM, Austin, B, Auyang, L, Awwal, AS, Ayers, J, Ayers, S, Ayers, T, Azevedo, S, Bachmann, B, Back, CA, Bae, J, Bailey, DS, Bailey, J, Baisden, T, Baker, KL, Baldis, H, Barber, D, Barberis, M, Barker, D, Barnes, A, Barnes, CW, Barrios, MA, Barty, C, Bass, I, Batha, SH, Baxamusa, SH, Bazan, G, Beagle, JK, Beale, R, Beck, BR, Beck, JB, Bedzyk, M, Beeler, RG, Behrendt, W, Belk, L, Bell, P, Belyaev, M, Benage, JF, Bennett, G, Benedetti, LR, Benedict, LX, Berger, R, Bernat, T, Bernstein, LA, Berry, B, Bertolini, L, Besenbruch, G, Betcher, J, Bettenhausen, R, Betti, R, Bezzerides, B, Bhandarkar, SD, Bickel, R, Biener, J, Biesiada, T, Bigelow, K, Bigelow-Granillo, J, Bigman, V, Bionta, RM, Birge, NW, Bitter, M, Black, AC, Bleile, R, Bleuel, DL, Bliss, E, Blue, B, Boehly, T, Boehm, K, Boley, CD, Bonanno, R, Bond, EJ, Bond, T, Bonino, MJ, Borden, M, Bourgade, J-L, Bousquet, J, Bowers, J, Bowers, M, Boyd, R, Bozek, A, Bradley, DK, Bradley, KS, Bradley, PA, Bradley, L, Brannon, L, Brantley, PS, Braun, D, Braun, T, Brienza-Larsen, K, Briggs, TM, Britten, J, Brooks, ED, Browning, D, Bruhn, MW, Brunner, TA, Bruns, H, Brunton, G, Bryant, B, Buczek, T, Bude, J, Buitano, L, Burkhart, S, Burmark, J, Burnham, A, Burr, R, Busby, LE, Butlin, B, Cabeltis, R, Cable, M, Cabot, WH, Cagadas, B, Caggiano, J, Cahayag, R, Caldwell, SE, Calkins, S, Callahan, DA, Calleja-Aguirre, J, Camara, L, Camp, D, Campbell, EM, Campbell, JH, Carey, B, Carey, R, Carlisle, K, Carlson, L, Carman, L, Carmichael, J, Carpenter, A, Carr, C, Carrera, JA, Casavant, D, Casey, A, Casey, DT, Castillo, A, Castillo, E, Castor, JI, Castro, C, Caughey, W, Cavitt, R, Celeste, J, Celliers, PM, Cerjan, C, Chandler, G, Chang, B, Chang, C, Chang, J, Chang, L, Chapman, R, Chapman, T, Chase, L, Chen, H, Chen, K, Chen, L-Y, Cheng, B, Chittenden, J, Choate, C, Chou, J, Chrien, RE, Chrisp, M, Christensen, K, Christensen, M, Christopherson, AR, Chung, M, Church, JA, Clark, A, Clark, DS, Clark, K, Clark, R, Claus, L, Cline, B, Cline, JA, Cobble, JA, Cochrane, K, Cohen, B, Cohen, S, Collette, MR, Collins, G, Collins, LA, Collins, TJB, Conder, A, Conrad, B, Conyers, M, Cook, AW, Cook, D, Cook, R, Cooley, JC, Cooper, G, Cope, T, Copeland, SR, Coppari, F, Cortez, J, Cox, J, Crandall, DH, Crane, J, Craxton, RS, Cray, M, Crilly, A, Crippen, JW, Cross, D, Cuneo, M, Cuotts, G, Czajka, CE, Czechowicz, D, Daly, T, Danforth, P, Darbee, R, Darlington, B, Datte, P, Dauffy, L, Davalos, G, Davidovits, S, Davis, P, Davis, J, Dawson, S, Day, RD, Day, TH, Dayton, M, Deck, C, Decker, C, Deeney, C, DeFriend, KA, Deis, G, Delamater, ND, Delettrez, JA, Demaret, R, Demos, S, Dempsey, SM, Desjardin, R, Desjardins, T, Desjarlais, MP, Dewald, EL, DeYoreo, J, Diaz, S, Dimonte, G, Dittrich, TR, Divol, L, Dixit, SN, Dixon, J, Dodd, ES, Dolan, D, Donovan, A, Donovan, M, Döppner, T, Dorrer, C, Dorsano, N, Douglas, MR, Dow, D, Downie, J, Downing, E, Dozieres, M, Draggoo, V, Drake, D, Drake, RP, Drake, T, Dreifuerst, G, DuBois, DF, DuBois, PF, Dunham, G, Dylla-Spears, R, Dymoke-Bradshaw, AKL, Dzenitis, B, Ebbers, C, Eckart, M, Eddinger, S, Eder, D, Edgell, D, Edwards, MJ, Efthimion, P, Eggert, JH, Ehrlich, B, Ehrmann, P, Elhadj, S, Ellerbee, C, Elliott, NS, Ellison, CL, Elsner, F, Emerich, M, Engelhorn, K, England, T, English, E, Epperson, P, Epstein, R, Erbert, G, Erickson, MA, Erskine, DJ, Erlandson, A, Espinosa, RJ, Estes, C, Estabrook, KG, Evans, S, Fabyan, A, Fair, J, Fallejo, R, Farmer, N, Farmer, WA, Farrell, M, Fatherley, VE, Fedorov, M, Feigenbaum, E, Feit, M, Ferguson, W, Fernandez, JC, Fernandez-Panella, A, Fess, S, Field, JE, Filip, CV, Fincke, JR, Finn, T, Finnegan, SM, Finucane, RG, Fischer, M, Fisher, A, Fisher, J, Fishler, B, Fittinghoff, D, Fitzsimmons, P, Flegel, M, Flippo, KA, Florio, J, Folta, J, Folta, P, Foreman, LR, Forrest, C, Forsman, A, Fooks, J, Foord, M, Fortner, R, Fournier, K, Fratanduono, DE, Frazier, N, Frazier, T, Frederick, C, Freeman, MS, Frenje, J, Frey, D, Frieders, G, Friedrich, S, Froula, DH, Fry, J, Fuller, T, Gaffney, J, Gales, S, Le Galloudec, B, Le Galloudec, KK, Gambhir, A, Gao, L, Garbett, WJ, Garcia, A, Gates, C, Gaut, E, Gauthier, P, Gavin, Z, Gaylord, J, Geissel, M, Génin, F, Georgeson, J, Geppert-Kleinrath, H, Geppert-Kleinrath, V, Gharibyan, N, Gibson, J, Gibson, C, Giraldez, E, Glebov, V, Glendinning, SG, Glenn, S, Glenzer, SH, Goade, S, Gobby, PL, Goldman, SR, Golick, B, Gomez, M, Goncharov, V, Goodin, D, Grabowski, P, Grafil, E, Graham, P, Grandy, J, Grasz, E, Graziani, F, Greenman, G, Greenough, JA, Greenwood, A, Gregori, G, Green, T, Griego, JR, Grim, GP, Grondalski, J, Gross, S, Guckian, J, Guler, N, Gunney, B, Guss, G, Haan, S, Hackbarth, J, Hackel, L, Hackel, R, Haefner, C, Hagmann, C, Hahn, KD, Hahn, S, Haid, BJ, Haines, BM, Hall, BM, Hall, C, Hall, GN, Hamamoto, M, Hamel, S, Hamilton, CE, Hammel, BA, Hammer, JH, Hampton, G, Hamza, A, Handler, A, Hansen, S, Hanson, D, Haque, R, Harding, D, Harding, E, Hares, JD, Harris, DB, Harte, JA, Hartouni, EP, Hatarik, R, Hatchett, S, Hauer, AA, Havre, M, Hawley, R, Hayes, J, Hayes, S, Hayes-Sterbenz, A, Haynam, CA, Haynes, DA, Headley, D, Heal, A, Heebner, JE, Heerey, S, Heestand, GM, Heeter, R, Hein, N, Heinbockel, C, Hendricks, C, Henesian, M, Heninger, J, Henrikson, J, Henry, EA, Herbold, EB, Hermann, MR, Hermes, G, Hernandez, JE, Hernandez, VJ, Herrmann, MC, Herrmann, HW, Herrera, OD, Hewett, D, Hibbard, R, Hicks, DG, Hill, D, Hill, K, 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Kauffman, R, Kaufman, MI, Keane, C, Keaty, L, Kegelmeyer, L, Keiter, PA, Kellett, PA, Kellogg, J, Kelly, JH, Kemic, S, Kemp, AJ, Kemp, GE, Kerbel, GD, Kershaw, D, Kerr, SM, Kessler, TJ, Key, MH, Khan, SF, Khater, H, Kiikka, C, Kilkenny, J, Kim, Y, Kim, Y-J, Kimko, J, Kimmel, M, Kindel, JM, King, J, Kirkwood, RK, Klaus, L, Klem, D, Kline, JL, Klingmann, J, Kluth, G, Knapp, P, Knauer, J, Knipping, J, Knudson, M, Kobs, D, Koch, J, Kohut, T, Kong, C, Koning, JM, Koning, P, Konior, S, Kornblum, H, Kot, LB, Kozioziemski, B, Kozlowski, M, Kozlowski, PM, Krammen, J, Krasheninnikova, NS, Kraus, B, Krauser, W, Kress, JD, Kritcher, AL, Krieger, E, Kroll, JJ, Kruer, WL, Kruse, MKG, Kucheyev, S, Kumbera, M, Kumpan, S, Kunimune, J, Kustowski, B, Kwan, TJT, Kyrala, GA, Laffite, S, Lafon, M, LaFortune, K, Lahmann, B, Lairson, B, Landen, OL, Langenbrunner, J, Lagin, L, Land, T, Lane, M, Laney, D, Langdon, AB, Langer, SH, Langro, A, Lanier, NE, Lanier, TE, Larson, D, Lasinski, BF, Lassle, D, LaTray, D, Lau, G, Lau, N, Laumann, C, Laurence, A, Laurence, TA, Lawson, J, Le, HP, Leach, RR, Leal, L, Leatherland, A, LeChien, K, Lechleiter, B, Lee, A, Lee, M, Lee, T, Leeper, RJ, Lefebvre, E, Leidinger, J-P, LeMire, B, Lemke, RW, Lemos, NC, Le Pape, S, Lerche, R, Lerner, S, Letts, S, Levedahl, K, Lewis, T, Li, CK, Li, H, Li, J, Liao, W, Liao, ZM, Liedahl, D, Liebman, J, Lindford, G, Lindman, EL, Lindl, JD, Loey, H, London, RA, Long, F, Loomis, EN, Lopez, FE, Lopez, H, Losbanos, E, Loucks, S, Lowe-Webb, R, Lundgren, E, Ludwigsen, AP, Luo, R, Lusk, J, Lyons, R, Ma, T, Macallop, Y, MacDonald, MJ, MacGowan, BJ, Mack, JM, Mackinnon, AJ, MacLaren, SA, MacPhee, AG, Magelssen, GR, Magoon, J, Malone, RM, Malsbury, T, Managan, R, Mancini, R, Manes, K, Maney, D, Manha, D, Mannion, OM, Manuel, AM, Mapoles, E, Mara, G, Marcotte, T, Marin, E, Marinak, MM, Mariscal, C, Mariscal, DA, Mariscal, EF, Marley, EV, Marozas, JA, Marquez, R, Marshall, CD, Marshall, FJ, Marshall, M, Marshall, S, Marticorena, J, Martinez, D, Maslennikov, I, Mason, D, Mason, RJ, Masse, L, Massey, W, Masson-Laborde, P-E, Masters, ND, Mathisen, D, Mathison, E, Matone, J, Matthews, MJ, Mattoon, C, Mattsson, TR, Matzen, K, Mauche, CW, Mauldin, M, McAbee, T, McBurney, M, Mccarville, T, McCrory, RL, McEvoy, AM, McGuffey, C, Mcinnis, M, McKenty, P, McKinley, MS, McLeod, JB, McPherson, A, Mcquillan, B, Meamber, M, Meaney, KD, Meezan, NB, Meissner, R, Mehlhorn, TA, Mehta, NC, Menapace, J, Merrill, FE, Merritt, BT, Merritt, EC, Meyerhofer, DD, Mezyk, S, Mich, RJ, Michel, PA, Milam, D, Miller, C, Miller, D, Miller, DS, Miller, E, Miller, EK, Miller, J, Miller, M, Miller, PE, Miller, T, Miller, W, Miller-Kamm, V, Millot, M, Milovich, JL, Minner, P, Miquel, J-L, Mitchell, S, Molvig, K, Montesanti, RC, Montgomery, DS, Monticelli, M, Montoya, A, Moody, JD, Moore, AS, Moore, E, Moran, M, Moreno, JC, Moreno, K, Morgan, BE, Morrow, T, Morton, JW, Moses, E, Moy, K, Muir, R, Murillo, MS, Murray, JE, Murray, JR, Munro, DH, Murphy, TJ, Munteanu, FM, Nafziger, J, Nagayama, T, Nagel, SR, Nast, R, Negres, RA, Nelson, A, Nelson, D, Nelson, J, Nelson, S, Nemethy, S, Neumayer, P, Newman, K, Newton, M, Nguyen, H, Di Nicola, J-MG, Di Nicola, P, Niemann, C, Nikroo, A, Nilson, PM, Nobile, A, Noorai, V, Nora, R, Norton, M, Nostrand, M, Note, V, Novell, S, Nowak, PF, Nunez, A, Nyholm, RA, O'Brien, M, Oceguera, A, Oertel, JA, Okui, J, Olejniczak, B, Oliveira, J, Olsen, P, Olson, B, Olson, K, Olson, RE, Opachich, YP, Orsi, N, Orth, CD, Owen, M, Padalino, S, Padilla, E, Paguio, R, Paguio, S, Paisner, J, Pajoom, S, Pak, A, Palaniyappan, S, Palma, K, Pannell, T, Papp, F, Paras, D, Parham, T, Park, H-S, Pasternak, A, Patankar, S, Patel, MV, Patel, PK, Patterson, R, Patterson, S, Paul, B, Paul, M, Pauli, E, Pearce, OT, Pearcy, J, Pedrotti, B, Peer, A, Pelz, LJ, Penetrante, B, Penner, J, Perez, A, Perkins, LJ, Pernice, E, Perry, TS, Person, S, Petersen, D, Petersen, T, Peterson, DL, Peterson, EB, Peterson, JE, Peterson, JL, Peterson, K, Peterson, RR, Petrasso, RD, Philippe, F, Phipps, TJ, Piceno, E, Ping, Y, Pickworth, L, Pino, J, Plummer, R, Pollack, GD, Pollaine, SM, Pollock, BB, Ponce, D, Ponce, J, Pontelandolfo, J, Porter, JL, Post, J, Poujade, O, Powell, C, Powell, H, Power, G, Pozulp, M, Prantil, M, Prasad, M, Pratuch, S, Price, S, Primdahl, K, Prisbrey, S, Procassini, R, Pruyne, A, Pudliner, B, Qiu, SR, Quan, K, Quinn, M, Quintenz, J, Radha, PB, Rainer, F, Ralph, JE, Raman, KS, Raman, R, Rambo, P, Rana, S, Randewich, A, Rardin, D, Ratledge, M, Ravelo, N, Ravizza, F, Rayce, M, Raymond, A, Raymond, B, Reed, B, Reed, C, Regan, S, Reichelt, B, Reis, V, Reisdorf, S, Rekow, V, Remington, BA, Rendon, A, Requieron, W, Rever, M, Reynolds, H, Reynolds, J, Rhodes, J, Rhodes, M, Richardson, MC, Rice, B, Rice, NG, Rieben, R, Rigatti, A, Riggs, S, Rinderknecht, HG, Ring, K, Riordan, B, Riquier, R, Rivers, C, Roberts, D, Roberts, V, Robertson, G, Robey, HF, Robles, J, Rocha, P, Rochau, G, Rodriguez, J, Rodriguez, S, Rosen, M, Rosenberg, M, Ross, G, Ross, JS, Ross, P, Rouse, J, Rovang, D, Rubenchik, AM, Rubery, MS, Ruiz, CL, Rushford, M, Russ, B, Rygg, JR, Ryujin, BS, Sacks, RA, Sacks, RF, Saito, K, Salmon, T, Salmonson, JD, Sanchez, J, Samuelson, S, Sanchez, M, Sangster, C, Saroyan, A, Sater, J, Satsangi, A, Sauers, S, Saunders, R, Sauppe, JP, Sawicki, R, Sayre, D, Scanlan, M, Schaffers, K, Schappert, GT, Schiaffino, S, Schlossberg, DJ, Schmidt, DW, Schmitt, MJ, Schneider, DHG, Schneider, MB, Schneider, R, Schoff, M, Schollmeier, M, Schölmerich, M, Schroeder, CR, Schrauth, SE, Scott, HA, Scott, I, Scott, JM, Scott, RHH, Scullard, CR, Sedillo, T, Seguin, FH, Seka, W, Senecal, J, Sepke, SM, Seppala, L, Sequoia, K, Severyn, J, Sevier, JM, Sewell, N, Seznec, S, Shah, RC, Shamlian, J, Shaughnessy, D, Shaw, M, Shaw, R, Shearer, C, Shelton, R, Shen, N, Sherlock, MW, Shestakov, AI, Shi, EL, Shin, SJ, Shingleton, N, Shmayda, W, Shor, M, Shoup, M, Shuldberg, C, Siegel, L, Silva, FJ, Simakov, AN, Sims, BT, Sinars, D, Singh, P, Sio, H, Skulina, K, Skupsky, S, Slutz, S, Sluyter, M, Smalyuk, VA, Smauley, D, Smeltser, RM, Smith, C, Smith, I, Smith, J, Smith, L, Smith, R, Sohn, R, Sommer, S, Sorce, C, Sorem, M, Soures, JM, Spaeth, ML, Spears, BK, Speas, S, Speck, D, Speck, R, Spears, J, Spinka, T, Springer, PT, Stadermann, M, Stahl, B, Stahoviak, J, Stanton, LG, Steele, R, Steele, W, Steinman, D, Stemke, R, Stephens, R, Sterbenz, S, Sterne, P, Stevens, D, Stevers, J, Still, CB, Stoeckl, C, Stoeffl, W, Stolken, JS, Stolz, C, Storm, E, Stone, G, Stoupin, S, Stout, E, Stowers, I, Strauser, R, Streckart, H, Streit, J, Strozzi, DJ, Suratwala, T, Sutcliffe, G, Suter, LJ, Sutton, SB, Svidzinski, V, Swadling, G, Sweet, W, Szoke, A, Tabak, M, Takagi, M, Tambazidis, A, Tang, V, Taranowski, M, Taylor, LA, Telford, S, Theobald, W, Thi, M, Thomas, A, Thomas, CA, Thomas, I, Thomas, R, Thompson, IJ, Thongstisubskul, A, Thorsness, CB, Tietbohl, G, Tipton, RE, Tobin, M, Tomlin, N, Tommasini, R, Toreja, AJ, Torres, J, Town, RPJ, Townsend, S, Trenholme, J, Trivelpiece, A, Trosseille, C, Truax, H, Trummer, D, Trummer, S, Truong, T, Tubbs, D, Tubman, ER, Tunnell, T, Turnbull, D, Turner, RE, Ulitsky, M, Upadhye, R, Vaher, JL, VanArsdall, P, VanBlarcom, D, Vandenboomgaerde, M, VanQuinlan, R, Van Wonterghem, BM, Varnum, WS, Velikovich, AL, Vella, A, Verdon, CP, Vermillion, B, Vernon, S, Vesey, R, Vickers, J, Vignes, RM, Visosky, M, Vocke, J, Volegov, PL, Vonhof, S, Von Rotz, R, Vu, HX, Vu, M, Wall, D, Wall, J, Wallace, R, Wallin, B, Walmer, D, Walsh, CA, Walters, CF, Waltz, C, Wan, A, Wang, A, Wang, Y, Wark, JS, Warner, BE, Watson, J, Watt, RG, Watts, P, Weaver, J, Weaver, RP, Weaver, S, Weber, CR, Weber, P, Weber, SV, Wegner, P, Welday, B, Welser-Sherrill, L, Weiss, K, Widmann, K, Wheeler, GF, Whistler, W, White, RK, Whitley, HD, Whitman, P, Wickett, ME, Widmayer, C, Wiedwald, J, Wilcox, R, Wilcox, S, Wild, C, Wilde, BH, Wilde, CH, Wilhelmsen, K, Wilke, MD, Wilkens, H, Wilkins, P, Wilks, SC, Williams, EA, Williams, GJ, Williams, W, Williams, WH, Wilson, DC, Wilson, B, Wilson, E, Wilson, R, Winters, S, Wisoff, J, Wittman, M, Wolfe, J, Wong, A, Wong, KW, Wong, L, Wong, N, Wood, R, Woodhouse, D, Woodruff, J, Woods, DT, Woods, S, Woodworth, BN, Wooten, E, Wootton, A, Work, K, Workman, JB, Wright, J, Wu, M, Wuest, C, Wysocki, FJ, Xu, H, Yamaguchi, M, Yang, B, Yang, ST, Yatabe, J, Yeamans, CB, Yee, BC, Yi, SA, Yin, L, Young, B, Young, CS, Young, CV, Young, P, Youngblood, K, Zacharias, R, Zagaris, G, Zaitseva, N, Zaka, F, Ze, F, Zeiger, B, Zika, M, Zimmerman, GB, Zobrist, T, Zuegel, JD, Zylstra, AB, Indirect Drive ICF Collaboration, Collaboration, Indirect Drive ICF, AWE Plc, Lawrence Livermore National Laboratory, and U.S Department of Energy

Subjects
General Physics, 02 Physical Sciences, General Physics and Astronomy, Indirect Drive ICF Collaboration, 01 Mathematical Sciences, 09 Engineering
Abstract

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion.

Published
2022

5. The national ignition facility: laser performance status and performance quad results at elevated energy

Author

Di Nicola, J.M., primary, Bond, T., additional, Bowers, M., additional, Chang, L., additional, Hermann, M., additional, House, R., additional, Lewis, T., additional, Manes, K., additional, Mennerat, G., additional, MacGowan, B., additional, Negres, R., additional, Olejniczak, B., additional, Orth, C., additional, Parham, T., additional, Rana, S., additional, Raymond, B., additional, Rever, M., additional, Schrauth, S., additional, Shaw, M., additional, Spaeth, M., additional, Van Wonterghem, B., additional, Williams, W., additional, Widmayer, C., additional, Yang, S., additional, Whitman, P., additional, and Wegner, P., additional

Published
2018
Full Text
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7. Publisher’s Note: Demonstration of Ignition Radiation Temperatures in Indirect-Drive Inertial Confinement Fusion Hohlraums [Phys. Rev. Lett.106, 085004 (2011)]

Author

Glenzer, S. H., primary, MacGowan, B. J., additional, Meezan, N. B., additional, Adams, P. A., additional, Alfonso, J. B., additional, Alger, E. T., additional, Alherz, Z., additional, Alvarez, L. F., additional, Alvarez, S. S., additional, Amick, P. V., additional, Andersson, K. S., additional, Andrews, S. D., additional, Antonini, G. J., additional, Arnold, P. A., additional, Atkinson, D. P., additional, Auyang, L., additional, Azevedo, S. G., additional, Balaoing, B. N. M., additional, Baltz, J. A., additional, Barbosa, F., additional, Bardsley, G. W., additional, Barker, D. A., additional, Barnes, A. I., additional, Baron, A., additional, Beeler, R. G., additional, Beeman, B. V., additional, Belk, L. R., additional, Bell, J. C., additional, Bell, P. M., additional, Berger, R. L., additional, Bergonia, M. A., additional, Bernardez, L. J., additional, Berzins, L. V., additional, Bettenhausen, R. C., additional, Bhandarkar, S. D., additional, Bishop, C. L., additional, Bond, E. J., additional, Bopp, D. R., additional, Borgman, J. A., additional, Bower, J. R., additional, Bowers, G. A., additional, Bowers, M. W., additional, Boyle, D. T., additional, Bradley, D. K., additional, Bragg, J. L., additional, Braucht, J., additional, Brinkerhoff, D. L., additional, Browning, D. F., additional, Brunton, G. K., additional, Burkhart, S. C., additional, Burns, S. R., additional, Burns, K. E., additional, Burr, B., additional, Burrows, L. M., additional, Butlin, R. K., additional, Cahayag, N. J., additional, Callahan, D. A., additional, Cardinale, P. S., additional, Carey, R. W., additional, Carlson, J. W., additional, Casey, A. D., additional, Castro, C., additional, Celeste, J. R., additional, Chakicherla, A. Y., additional, Chambers, F. W., additional, Chan, C., additional, Chandrasekaran, H., additional, Chang, C., additional, Chapman, R. F., additional, Charron, K., additional, Chen, Y., additional, Christensen, M. J., additional, Churby, A. J., additional, Clancy, T. J., additional, Cline, B. D., additional, Clowdus, L. C., additional, Cocherell, D. G., additional, Coffield, F. E., additional, Cohen, S. J., additional, Costa, R. L., additional, Cox, J. R., additional, Curnow, G. M., additional, Dailey, M. J., additional, Danforth, P. M., additional, Darbee, R., additional, Datte, P. S., additional, Davis, J. A., additional, Deis, G. A., additional, Demaret, R. D., additional, Dewald, E. L., additional, Di Nicola, P., additional, Di Nicola, J. M., additional, Divol, L., additional, Dixit, S., additional, Dobson, D. B., additional, Doppner, T., additional, Driscoll, J. D., additional, Dugorepec, J., additional, Duncan, J. J., additional, DuPuy, P. C., additional, Dzenitis, E. G., additional, Eckart, M. J., additional, Edson, S. L., additional, Edwards, G. J., additional, Edwards, M. J., additional, Edwards, O. D., additional, Edwards, P. W., additional, Ellefson, J. C., additional, Ellerbee, C. H., additional, Erbert, G. V., additional, Estes, C. M., additional, Fabyan, W. J., additional, Fallejo, R. N., additional, Fedorov, M., additional, Felker, B., additional, Fink, J. T., additional, Finney, M. D., additional, Finnie, L. F., additional, Fischer, M. J., additional, Fisher, J. M., additional, Fishler, B. T., additional, Florio, J. W., additional, Foxworthy, C. B., additional, Franks, R. M., additional, Frazier, T., additional, Frieder, G., additional, Fung, T., additional, Gawinski, G. N., additional, Gibson, C. R., additional, Giraldez, E., additional, Glenn, S. M., additional, Golick, B. P., additional, Gonzales, H., additional, Gonzales, S. A., additional, Gonzales, M. J., additional, Griffin, K. L., additional, Grippen, J., additional, Gross, S. M., additional, Gschweng, P. H., additional, Gururangan, G., additional, Gu, K., additional, Haan, S. W., additional, Hahn, S. R., additional, Haid, B. J., additional, Hamblen, J. E., additional, Hammel, B. A., additional, Hamza, A. V., additional, Hardy, D. L., additional, Hart, D. R., additional, Hartley, R. G., additional, Haynam, C. A., additional, Heestand, G. M., additional, Hermann, M. R., additional, Hermes, G. L., additional, Hey, D. S., additional, Hibbard, R. L., additional, Hicks, D. G., additional, Hinkel, D. E., additional, Hipple, D. L., additional, Hitchcock, J. D., additional, Hodtwalker, D. L., additional, Holder, J. P., additional, Hollis, J. D., additional, Holtmeier, G. M., additional, Huber, S. R., additional, Huey, A. W., additional, Hulsey, D. N., additional, Hunter, S. L., additional, Huppler, T. R., additional, Hutton, M. S., additional, Izumi, N., additional, Jackson, J. L., additional, Jackson, M. A., additional, Jancaitis, K. S., additional, Jedlovec, D. R., additional, Johnson, B., additional, Johnson, M. C., additional, Johnson, T., additional, Johnston, M. P., additional, Jones, O. S., additional, Kalantar, D. H., additional, Kamperschroer, J. H., additional, Kauffman, R. L., additional, Keating, G. A., additional, Kegelmeyer, L. M., additional, Kenitzer, S. L., additional, Kimbrough, J. R., additional, King, K., additional, Kirkwood, R. K., additional, Klingmann, J. L., additional, Knittel, K. M., additional, Kohut, T. R., additional, Koka, K. G., additional, Kramer, S. W., additional, Krammen, J. E., additional, Krauter, K. G., additional, Krauter, G. W., additional, Krieger, E. K., additional, Kroll, J. J., additional, La Fortune, K. N., additional, Lagin, L. J., additional, Lakamsani, V. K., additional, Landen, O. L., additional, Lane, S. W., additional, Langdon, A. B., additional, Langer, S. H., additional, Lao, N., additional, Larson, D. W., additional, Latray, D. A., additional, Lau, G. T., additional, Le Pape, S., additional, Lechleiter, B. L., additional, Lee, Y., additional, Lee, T. L., additional, Li, J., additional, Liebman, J. A., additional, Lindl, J. D., additional, Locke, S. F., additional, Loey, H. K., additional, London, R. A., additional, Lopez, F. J., additional, Lord, D. M., additional, Lowe-Webb, R. R., additional, Lown, J. G., additional, Ludwigsen, A. P., additional, Lum, N. W., additional, Lyons, R. R., additional, Ma, T., additional, MacKinnon, A. J., additional, Magat, M. D., additional, Maloy, D. T., additional, Malsbury, T. N., additional, Markham, G., additional, Marquez, R. M., additional, Marsh, A. A., additional, Marshall, C. D., additional, Marshall, S. R., additional, Maslennikov, I. L., additional, Mathisen, D. G., additional, Mauger, G. J., additional, Mauvais, M.-Y., additional, McBride, J. A., additional, McCarville, T., additional, McCloud, J. B., additional, McGrew, A., additional, McHale, B., additional, MacPhee, A. G., additional, Meeker, J. F., additional, Merill, J. S., additional, Mertens, E. P., additional, Michel, P. A., additional, Miller, M. G., additional, Mills, T. E., additional, Milovich, J. L., additional, Miramontes-Ortiz, R., additional, Montesanti, R. C., additional, Montoya, M. M., additional, Moody, J., additional, Moody, J. D., additional, Moreno, K. A., additional, Morris, J., additional, Morriston, K. M., additional, Nelson, J. R., additional, Neto, M., additional, Neumann, J. D., additional, Ng, E., additional, Ngo, Q. M., additional, Olejniczak, B. L., additional, Olson, R. E., additional, Orsi, N. L., additional, Owens, M. W., additional, Padilla, E. H., additional, Pannell, T. M., additional, Parham, T. G., additional, Patterson, R. W., additional, Pavel, G., additional, Prasad, R. R., additional, Pendleton, D., additional, Penko, F. A., additional, Pepmeier, B. L., additional, Petersen, D. E., additional, Phillips, T. W., additional, Pigg, D., additional, Piston, K. W., additional, Pletcher, K. D., additional, Powell, C. L., additional, Radousky, H. B., additional, Raimondi, B. S., additional, Ralph, J. E., additional, Rampke, R. L., additional, Reed, R. K., additional, Reid, W. A., additional, Rekow, V. V., additional, Reynolds, J. L., additional, Rhodes, J. J., additional, Richardson, M. J., additional, Rinnert, R. J., additional, Riordan, B. P., additional, Rivenes, A. S., additional, Rivera, A. T., additional, Roberts, C. J., additional, Robinson, J. A., additional, Robinson, R. B., additional, Robison, S. R., additional, Rodriguez, O. R., additional, Rogers, S. P., additional, Rosen, M. D., additional, Ross, G. F., additional, Runkel, M., additional, Runtal, A. S., additional, Sacks, R. A., additional, Sailors, S. F., additional, Salmon, J. T., additional, Salmonson, J. D., additional, Saunders, R. L., additional, Schaffer, J. R., additional, Schindler, T. M., additional, Schmitt, M. J., additional, Schneider, M. B., additional, Segraves, K. S., additional, Shaw, M. J., additional, Sheldrick, M. E., additional, Shelton, R. T., additional, Shiflett, M. K., additional, Shiromizu, S. J., additional, Shor, M., additional, Silva, L. L., additional, Silva, S. A., additional, Skulina, K. M., additional, Smauley, D. A., additional, Smith, B. E., additional, Smith, L. K., additional, Solomon, A. L., additional, Sommer, S., additional, Soto, J. G., additional, Spafford, N. I., additional, Speck, D. E., additional, Springer, P. T., additional, Stadermann, M., additional, Stanley, F., additional, Stone, T. G., additional, Stout, E. A., additional, Stratton, P. L., additional, Strauser, R. J., additional, Suter, L. J., additional, Sweet, W., additional, Swisher, M. F., additional, Tappero, J. D., additional, Tassano, J. B., additional, Taylor, J. S., additional, Tekle, E. A., additional, Thai, C., additional, Thomas, C. A., additional, Thomas, A., additional, Throop, A. L., additional, Tietbohl, G. L., additional, Tillman, J. M., additional, Town, R. P. J., additional, Townsend, S. L., additional, Tribbey, K. L., additional, Trummer, D. J., additional, Truong, J. H., additional, Vaher, J. L., additional, Valadez, M. C., additional, Van Arsdall, P. J., additional, Van Prooyen, A. J., additional, Vergel de Dios, E. O., additional, Vergino, M. D., additional, Vernon, S. P., additional, Vickers, J. L., additional, Villanueva, G. T., additional, Vitalich, M. A., additional, Vonhof, S. A., additional, Wade, F. E., additional, Wallace, R. J., additional, Warren, C. T., additional, Warrick, A. L., additional, Watkins, J., additional, Weaver, S., additional, Wegner, P. J., additional, Weingart, M. A., additional, Wen, J., additional, White, K. S., additional, Whitman, P. K., additional, Widmann, K., additional, Widmayer, C. C., additional, Wilhelmsen, K., additional, Williams, E. A., additional, Williams, W. H., additional, Willis, L., additional, Wilson, E. F., additional, Wilson, B. A., additional, Witte, M. C., additional, Work, K., additional, Yang, P. S., additional, Young, B. K., additional, Youngblood, K. P., additional, Zacharias, R. A., additional, Zapata, P. G., additional, Zhang, H., additional, Zielinski, J. S., additional, Kline, J. L., additional, Kyrala, G. A., additional, Niemann, C., additional, Kilkenny, J. D., additional, Nikroo, A., additional, Van Wonterghem, B. M., additional, Atherton, L. J., additional, and Moses, E. I., additional

Published
2011
Full Text
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8. Demonstration of Ignition Radiation Temperatures in Indirect-Drive Inertial Confinement Fusion Hohlraums

Author

Glenzer, S. H., primary, MacGowan, B. J., additional, Meezan, N. B., additional, Adams, P. A., additional, Alfonso, J. B., additional, Alger, E. T., additional, Alherz, Z., additional, Alvarez, L. F., additional, Alvarez, S. S., additional, Amick, P. V., additional, Andersson, K. S., additional, Andrews, S. D., additional, Antonini, G. J., additional, Arnold, P. A., additional, Atkinson, D. P., additional, Auyang, L., additional, Azevedo, S. G., additional, Balaoing, B. N. M., additional, Baltz, J. A., additional, Barbosa, F., additional, Bardsley, G. W., additional, Barker, D. A., additional, Barnes, A. I., additional, Baron, A., additional, Beeler, R. G., additional, Beeman, B. V., additional, Belk, L. R., additional, Bell, J. C., additional, Bell, P. M., additional, Berger, R. L., additional, Bergonia, M. A., additional, Bernardez, L. J., additional, Berzins, L. V., additional, Bettenhausen, R. C., additional, Bezerides, L., additional, Bhandarkar, S. D., additional, Bishop, C. L., additional, Bond, E. J., additional, Bopp, D. R., additional, Borgman, J. A., additional, Bower, J. R., additional, Bowers, G. A., additional, Bowers, M. W., additional, Boyle, D. T., additional, Bradley, D. K., additional, Bragg, J. L., additional, Braucht, J., additional, Brinkerhoff, D. L., additional, Browning, D. F., additional, Brunton, G. K., additional, Burkhart, S. C., additional, Burns, S. R., additional, Burns, K. E., additional, Burr, B., additional, Burrows, L. M., additional, Butlin, R. K., additional, Cahayag, N. J., additional, Callahan, D. A., additional, Cardinale, P. S., additional, Carey, R. W., additional, Carlson, J. W., additional, Casey, A. D., additional, Castro, C., additional, Celeste, J. R., additional, Chakicherla, A. Y., additional, Chambers, F. W., additional, Chan, C., additional, Chandrasekaran, H., additional, Chang, C., additional, Chapman, R. F., additional, Charron, K., additional, Chen, Y., additional, Christensen, M. J., additional, Churby, A. J., additional, Clancy, T. J., additional, Cline, B. D., additional, Clowdus, L. C., additional, Cocherell, D. G., additional, Coffield, F. E., additional, Cohen, S. J., additional, Costa, R. L., additional, Cox, J. R., additional, Curnow, G. M., additional, Dailey, M. J., additional, Danforth, P. M., additional, Darbee, R., additional, Datte, P. S., additional, Davis, J. A., additional, Deis, G. A., additional, Demaret, R. D., additional, Dewald, E. L., additional, Di Nicola, P., additional, Di Nicola, J. M., additional, Divol, L., additional, Dixit, S., additional, Dobson, D. B., additional, Doppner, T., additional, Driscoll, J. D., additional, Dugorepec, J., additional, Duncan, J. J., additional, Dupuy, P. C., additional, Dzenitis, E. G., additional, Eckart, M. J., additional, Edson, S. L., additional, Edwards, G. J., additional, Edwards, M. J., additional, Edwards, O. D., additional, Edwards, P. W., additional, Ellefson, J. C., additional, Ellerbee, C. H., additional, Erbert, G. V., additional, Estes, C. M., additional, Fabyan, W. J., additional, Fallejo, R. N., additional, Fedorov, M., additional, Felker, B., additional, Fink, J. T, additional, Finney, M. D., additional, Finnie, L. F., additional, Fischer, M. J., additional, Fisher, J. M., additional, Fishler, B. T., additional, Florio, J. W., additional, Forsman, A., additional, Foxworthy, C. B., additional, Franks, R. M., additional, Frazier, T., additional, Frieder, G., additional, Fung, T., additional, Gawinski, G. N., additional, Gibson, C. R., additional, Giraldez, E., additional, Glenn, S. M., additional, Golick, B. P., additional, Gonzales, H., additional, Gonzales, S. A., additional, Gonzalez, M. J., additional, Griffin, K. L., additional, Grippen, J., additional, Gross, S. M., additional, Gschweng, P. H., additional, Gururangan, G., additional, Gu, K., additional, Haan, S. W., additional, Hahn, S. R., additional, Haid, B. J., additional, Hamblen, J. E., additional, Hammel, B. A., additional, Hamza, A. V., additional, Hardy, D. L., additional, Hart, D. R., additional, Hartley, R. G., additional, Haynam, C. A., additional, Heestand, G. M., additional, Hermann, M. R., additional, Hermes, G. L., additional, Hey, D. S., additional, Hibbard, R. L., additional, Hicks, D. G., additional, Hinkel, D. E., additional, Hipple, D. L., additional, Hitchcock, J. D., additional, Hodtwalker, D. L., additional, Holder, J. P., additional, Hollis, J. D., additional, Holtmeier, G. M., additional, Huber, S. R., additional, Huey, A. W., additional, Hulsey, D. N., additional, Hunter, S. L., additional, Huppler, T. R., additional, Hutton, M. S., additional, Izumi, N., additional, Jackson, J. L., additional, Jackson, M. A., additional, Jancaitis, K. S., additional, Jedlovec, D. R., additional, Johnson, B., additional, Johnson, M. C., additional, Johnson, T., additional, Johnston, M. P., additional, Jones, O. S., additional, Kalantar, D. H., additional, Kamperschroer, J. H., additional, Kauffman, R. L., additional, Keating, G. A., additional, Kegelmeyer, L. M., additional, Kenitzer, S. L., additional, Kimbrough, J. R., additional, King, K., additional, Kirkwood, R. K., additional, Klingmann, J. L., additional, Knittel, K. M., additional, Kohut, T. R., additional, Koka, K. G., additional, Kramer, S. W., additional, Krammen, J. E., additional, Krauter, K. G., additional, Krauter, G. W., additional, Krieger, E. K., additional, Kroll, J. J., additional, La Fortune, K. N., additional, Lagin, L. J., additional, Lakamsani, V. K., additional, Landen, O. L., additional, Lane, S. W., additional, Langdon, A. B., additional, Langer, S. H., additional, Lao, N., additional, Larson, D. W., additional, Latray, D., additional, Lau, G. T., additional, Le Pape, S., additional, Lechleiter, B. L., additional, Lee, Y., additional, Lee, T. L., additional, Li, J., additional, Liebman, J. A., additional, Lindl, J. D., additional, Locke, S. F., additional, Loey, H. K., additional, London, R. A., additional, Lopez, F. J., additional, Lord, D. M., additional, Lowe-Webb, R. R., additional, Lown, J. G., additional, Ludwigsen, A. P., additional, Lum, N. W., additional, Lyons, R. R., additional, Ma, T., additional, MacKinnon, A. J., additional, Magat, M. D., additional, Maloy, D. T., additional, Malsbury, T. N., additional, Markham, G., additional, Marquez, R. M., additional, Marsh, A. A., additional, Marshall, C. D., additional, Marshall, S. R., additional, Maslennikov, I. L., additional, Mathisen, D. G., additional, Mauger, G. J., additional, Mauvais, M. -Y., additional, McBride, J. A., additional, McCarville, T., additional, McCloud, J. B., additional, McGrew, A., additional, McHale, B., additional, MacPhee, A. G., additional, Meeker, J. F., additional, Merill, J. S., additional, Mertens, E. P., additional, Michel, P. A., additional, Miller, M. G., additional, Mills, T., additional, Milovich, J. L., additional, Miramontes, R., additional, Montesanti, R. C., additional, Montoya, M. M., additional, Moody, J., additional, Moody, J. D., additional, Moreno, K. A., additional, Morris, J., additional, Morriston, K. M., additional, Nelson, J. R., additional, Neto, M., additional, Neumann, J. D., additional, Ng, E., additional, Ngo, Q. M., additional, Olejniczak, B. L., additional, Olson, R. E., additional, Orsi, N. L., additional, Owens, M. W., additional, Padilla, E. H., additional, Pannell, T. M., additional, Parham, T. G., additional, Patterson, R. W., additional, Pavel, G., additional, Prasad, R. R., additional, Pendlton, D., additional, Penko, F. A., additional, Pepmeier, B. L., additional, Petersen, D. E., additional, Phillips, T. W., additional, Pigg, D., additional, Piston, K. W., additional, Pletcher, K. D., additional, Powell, C. L., additional, Radousky, H. B., additional, Raimondi, B. S., additional, Ralph, J. E., additional, Rampke, R. L., additional, Reed, R. K., additional, Reid, W. A., additional, Rekow, V. V., additional, Reynolds, J. L., additional, Rhodes, J. J., additional, Richardson, M. J., additional, Rinnert, R. J., additional, Riordan, B. P., additional, Rivenes, A. S., additional, Rivera, A. T., additional, Roberts, C. J., additional, Robinson, J. A., additional, Robinson, R. B., additional, Robison, S. R., additional, Rodriguez, O. R., additional, Rogers, S. P., additional, Rosen, M. D., additional, Ross, G. F., additional, Runkel, M., additional, Runtal, A. S., additional, Sacks, R. A., additional, Sailors, S. F., additional, Salmon, J. T., additional, Salmonson, J. D., additional, Saunders, R. L., additional, Schaffer, J. R., additional, Schindler, T. M., additional, Schmitt, M. J., additional, Schneider, M. B., additional, Segraves, K. S., additional, Shaw, M. J., additional, Sheldrick, M. E., additional, Shelton, R. T., additional, Shiflett, M. K., additional, Shiromizu, S. J., additional, Shor, M., additional, Silva, L. L., additional, Silva, S. A., additional, Skulina, K. M., additional, Smauley, D. A., additional, Smith, B. E., additional, Smith, L. K., additional, Solomon, A. L., additional, Sommer, S., additional, Soto, J. G., additional, Spafford, N. I., additional, Speck, D. E., additional, Springer, P. T., additional, Stadermann, M., additional, Stanley, F., additional, Stone, T. G., additional, Stout, E. A., additional, Stratton, P. L., additional, Strausser, R. J., additional, Suter, L. J., additional, Sweet, W., additional, Swisher, M. F., additional, Tappero, J. D., additional, Tassano, J. B., additional, Taylor, J. S., additional, Tekle, E. A., additional, Thai, C., additional, Thomas, C. A., additional, Thomas, A., additional, Throop, A. L., additional, Tietbohl, G. L., additional, Tillman, J. M., additional, Town, R. P. J., additional, Townsend, S. L., additional, Tribbey, K. L., additional, Trummer, D., additional, Truong, J., additional, Vaher, J., additional, Valadez, M., additional, Van Arsdall, P., additional, Van Prooyen, A. J., additional, Vergel de Dios, E. O., additional, Vergino, M. D., additional, Vernon, S. P., additional, Vickers, J. L., additional, Villanueva, G. T., additional, Vitalich, M. A., additional, Vonhof, S. A., additional, Wade, F. E., additional, Wallace, R. J., additional, Warren, C. T., additional, Warrick, A. L., additional, Watkins, J., additional, Weaver, S., additional, Wegner, P. J., additional, Weingart, M. A., additional, Wen, J., additional, White, K. S., additional, Whitman, P. K., additional, Widmann, K., additional, Widmayer, C. C., additional, Wilhelmsen, K., additional, Williams, E. A., additional, Williams, W. H., additional, Willis, L., additional, Wilson, E F., additional, Wilson, B. A., additional, Witte, M. C., additional, Work, K., additional, Yang, P. S., additional, Young, B. K., additional, Youngblood, K. P., additional, Zacharias, R. A., additional, Zaleski, T., additional, Zapata, P. G., additional, Zhang, H., additional, Zielinski, J. S., additional, Kline, J. L., additional, Kyrala, G. A., additional, Niemann, C., additional, Kilkenny, J. D., additional, Nikroo, A., additional, Van Wonterghem, B. M., additional, Atherton, L. J., additional, and Moses, E. I., additional

Published
2011
Full Text
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23. Reductive and oxidative electrochemical study and spectroscopic properties of nickel(II) complexes with N2O2 Schiff bases derived from (±)-trans-N,N′-bis(salicylidene)-1,2-cyclohexanediamine.

Author

Tomczyk, D., Nowak, L., Bukowski, W., Bester, K., Urbaniak, P., Andrijewski, G., and Olejniczak, B.

Subjects
*ELECTROCHEMICAL analysis, *SPECTROMETRY, *NICKEL compounds, *METAL complexes, *SCHIFF bases, *DIAMINES, *OXIDATION, *CYCLIC voltammetry
Abstract

Abstract: Cyclic voltammetry, chronopotentiometry, chronocoulometry, controlled potential electrolysis and UV VIS were used in investigation of ligands and Ni(II) complexes with (±)-trans-N,N′-bis(salicylidene)-1,2-cyclohexanediamine substituted in orto- and/or para- positions of phenolate anions with tert-butyl and/or methoxy groups. Irreversible reduction and oxidation of ligands were shown. No influence of solvent on reduction of complexes, which results in Ni(I) complexes, was observed, however, an effect of solvent and substituents of phenolate anions on oxidation processes was proved. Anodic process in (CH3)2SO always results in appropriate Ni(III)-phenolate complex. Oxidation of orto- and para- substituted complexes in CH2Cl2 results in Ni(II)-mono-phenoxyl radicals, which undergo delocalisation and subsequently are oxidised to Ni(II)-bis-phenoxyl radicals. Last oxidation step of radicals produce long-lived Ni(II)-bis-phenoxonium cations. Complexes without substituents in para-and/or orto- position having formed Ni(II)-mono-phenoxyl radicals undergo dimerization. Mechanisms of electrode processes were studied and D and E f values for processes of reduction and Ist step of oxidation of complexes were calculated. [Copyright &y& Elsevier]

Published
2014
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24. The rs4354668 polymorphism in the SLC1A2 gene for the EAAT2 glutamate transporter is associated with an increased risk of harmful drug use - an exploratory study on a university student population.

Author

Dawidowski B, Olejniczak B, Groblińska K, Knapińska M, Kozicka U, Krasiński M, Kułak A, Grelecki G, Czaplińska Z, Piotrowska O, Kościelecka K, Podwalski P, Michalczyk A, and Samochowiec J

Subjects
Humans, Male, Female, Young Adult, Adult, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Glutamate Plasma Membrane Transport Proteins genetics, Students statistics & numerical data, Polymorphism, Genetic, Substance-Related Disorders genetics, Excitatory Amino Acid Transporter 2 genetics
Abstract

Objectives: Evidence suggests that decreased dopamine secretion in mesocorticolimbic pathways could predispose to increased susceptibility to substance addiction. It has been proposed to define such a phenomenon as the reward deficit syndrome (RDS). Dopaminergic projections of the reward system receive glutaminergic projections from cortex. Research indicates that a reduction in the stimulating glutamatergic transmission on the dopaminergic system could represent an alternative phenotype of RDS. Potential source of this type of abnormality is glutamate reuptake which depends on excitatory amino acid transport proteins (EAAT) function. The most important of them is EAAT2, polymorphisms of which have been linked to several mental disorders., Methods: We analyzed the genetic and psychometric data of 125 young adults (n = 125) for the effect of the rs4354668 polymorphism of the SLC1A2 gene for EAAT2 on the risky or harmful drug use (RHDU). After exploratory analysis we used logistic regression models to assess the probability of RHDU in individual groups., Results: In the final model T/T variant of rs4354668 was significantly associated with a lower probability of RHDU occurrence compared to G/G variant (OR: 0.021; 95% CI: 0.001 - 0.275; p = 0.009). Other significant predictors of RHDU were smoking status and risky or harmful drinking of alcohol., Conclusions: The results obtained may indicate a possible relationship of the risk of harmful drug use with variants of the rs4354668 polymorphism of the SLC1A2 gene for EAAT2. Subjects with the T/T variant of this polymorphism appear to be less at risk of developing drug use disorders.

Published
2024
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25. Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Author

Abu-Shawareb H, Acree R, Adams P, Adams J, Addis B, Aden R, Adrian P, Afeyan BB, Aggleton M, Aghaian L, Aguirre A, Aikens D, Akre J, Albert F, Albrecht M, Albright BJ, Albritton J, Alcala J, Alday C, Alessi DA, Alexander N, Alfonso J, Alfonso N, Alger E, Ali SJ, Ali ZA, Allen A, Alley WE, Amala P, Amendt PA, Amick P, Ammula S, Amorin C, Ampleford DJ, Anderson RW, Anklam T, Antipa N, Appelbe B, Aracne-Ruddle C, Araya E, Archuleta TN, Arend M, Arnold P, Arnold T, Arsenlis A, Asay J, Atherton LJ, Atkinson D, Atkinson R, Auerbach JM, Austin B, Auyang L, Awwal AAS, Aybar N, Ayers J, Ayers S, Ayers T, Azevedo S, Bachmann B, Back CA, Bae J, Bailey DS, Bailey J, Baisden T, Baker KL, Baldis H, Barber D, Barberis M, Barker D, Barnes A, Barnes CW, Barrios MA, Barty C, Bass I, Batha SH, Baxamusa SH, Bazan G, Beagle JK, Beale R, Beck BR, Beck JB, Bedzyk M, Beeler RG, Beeler RG, Behrendt W, Belk L, Bell P, Belyaev M, Benage JF, Bennett G, Benedetti LR, Benedict LX, Berger RL, Bernat T, Bernstein LA, Berry B, Bertolini L, Besenbruch G, Betcher J, Bettenhausen R, Betti R, Bezzerides B, Bhandarkar SD, Bickel R, Biener J, Biesiada T, Bigelow K, Bigelow-Granillo J, Bigman V, Bionta RM, Birge NW, Bitter M, Black AC, Bleile R, Bleuel DL, Bliss E, Bliss E, Blue B, Boehly T, Boehm K, Boley CD, Bonanno R, Bond EJ, Bond T, Bonino MJ, Borden M, Bourgade JL, Bousquet J, Bowers J, Bowers M, Boyd R, Boyle D, Bozek A, Bradley DK, Bradley KS, Bradley PA, Bradley L, Brannon L, Brantley PS, Braun D, Braun T, Brienza-Larsen K, Briggs R, Briggs TM, Britten J, Brooks ED, Browning D, Bruhn MW, Brunner TA, Bruns H, Brunton G, Bryant B, Buczek T, Bude J, Buitano L, Burkhart S, Burmark J, Burnham A, Burr R, Busby LE, Butlin B, Cabeltis R, Cable M, Cabot WH, Cagadas B, Caggiano J, Cahayag R, Caldwell SE, Calkins S, Callahan DA, Calleja-Aguirre J, Camara L, Camp D, Campbell EM, Campbell JH, Carey B, Carey R, Carlisle K, Carlson L, Carman L, Carmichael J, Carpenter A, Carr C, Carrera JA, Casavant D, Casey A, Casey DT, Castillo A, Castillo E, Castor JI, Castro C, Caughey W, Cavitt R, Celeste J, Celliers PM, Cerjan C, Chandler G, Chang B, Chang C, Chang J, Chang L, Chapman R, Chapman TD, Chase L, Chen H, Chen H, Chen K, Chen LY, Cheng B, Chittenden J, Choate C, Chou J, Chrien RE, Chrisp M, Christensen K, Christensen M, Christiansen NS, Christopherson AR, Chung M, Church JA, Clark A, Clark DS, Clark K, Clark R, Claus L, Cline B, Cline JA, Cobble JA, Cochrane K, Cohen B, Cohen S, Collette MR, Collins GW, Collins LA, Collins TJB, Conder A, Conrad B, Conyers M, Cook AW, Cook D, Cook R, Cooley JC, Cooper G, Cope T, Copeland SR, Coppari F, Cortez J, Cox J, Crandall DH, Crane J, Craxton RS, Cray M, Crilly A, Crippen JW, Cross D, Cuneo M, Cuotts G, Czajka CE, Czechowicz D, Daly T, Danforth P, Danly C, Darbee R, Darlington B, Datte P, Dauffy L, Davalos G, Davidovits S, Davis P, Davis J, Dawson S, Day RD, Day TH, Dayton M, Deck C, Decker C, Deeney C, DeFriend KA, Deis G, Delamater ND, Delettrez JA, Demaret R, Demos S, Dempsey SM, Desjardin R, Desjardins T, Desjarlais MP, Dewald EL, DeYoreo J, Diaz S, Dimonte G, Dittrich TR, Divol L, Dixit SN, Dixon J, Do A, Dodd ES, Dolan D, Donovan A, Donovan M, Döppner T, Dorrer C, Dorsano N, Douglas MR, Dow D, Downie J, Downing E, Dozieres M, Draggoo V, Drake D, Drake RP, Drake T, Dreifuerst G, Drury O, DuBois DF, DuBois PF, Dunham G, Durocher M, Dylla-Spears R, Dymoke-Bradshaw AKL, Dzenitis B, Ebbers C, Eckart M, Eddinger S, Eder D, Edgell D, Edwards MJ, Efthimion P, Eggert JH, Ehrlich B, Ehrmann P, Elhadj S, Ellerbee C, Elliott NS, Ellison CL, Elsner F, Emerich M, Engelhorn K, England T, English E, Epperson P, Epstein R, Erbert G, Erickson MA, Erskine DJ, Erlandson A, Espinosa RJ, Estes C, Estabrook KG, Evans S, Fabyan A, Fair J, Fallejo R, Farmer N, Farmer WA, Farrell M, Fatherley VE, Fedorov M, Feigenbaum E, Fehrenbach T, Feit M, Felker B, Ferguson W, Fernandez JC, Fernandez-Panella A, Fess S, Field JE, Filip CV, Fincke JR, Finn T, Finnegan SM, Finucane RG, Fischer M, Fisher A, Fisher J, Fishler B, Fittinghoff D, Fitzsimmons P, Flegel M, Flippo KA, Florio J, Folta J, Folta P, Foreman LR, Forrest C, Forsman A, Fooks J, Foord M, Fortner R, Fournier K, Fratanduono DE, Frazier N, Frazier T, Frederick C, Freeman MS, Frenje J, Frey D, Frieders G, Friedrich S, Froula DH, Fry J, Fuller T, Gaffney J, Gales S, Le Galloudec B, Le Galloudec KK, Gambhir A, Gao L, Garbett WJ, Garcia A, Gates C, Gaut E, Gauthier P, Gavin Z, Gaylord J, Geddes CGR, Geissel M, Génin F, Georgeson J, Geppert-Kleinrath H, Geppert-Kleinrath V, Gharibyan N, Gibson J, Gibson C, Giraldez E, Glebov V, Glendinning SG, Glenn S, Glenzer SH, Goade S, Gobby PL, Goldman SR, Golick B, Gomez M, Goncharov V, Goodin D, Grabowski P, Grafil E, Graham P, Grandy J, Grasz E, Graziani FR, Greenman G, Greenough JA, Greenwood A, Gregori G, Green T, Griego JR, Grim GP, Grondalski J, Gross S, Guckian J, Guler N, Gunney B, Guss G, Haan S, Hackbarth J, Hackel L, Hackel R, Haefner C, Hagmann C, Hahn KD, Hahn S, Haid BJ, Haines BM, Hall BM, Hall C, Hall GN, Hamamoto M, Hamel S, Hamilton CE, Hammel BA, Hammer JH, Hampton G, Hamza A, Handler A, Hansen S, Hanson D, Haque R, Harding D, Harding E, Hares JD, Harris DB, Harte JA, Hartouni EP, Hatarik R, Hatchett S, Hauer AA, Havre M, Hawley R, Hayes J, Hayes J, Hayes S, Hayes-Sterbenz A, Haynam CA, Haynes DA, Headley D, Heal A, Heebner JE, Heerey S, Heestand GM, Heeter R, Hein N, Heinbockel C, Hendricks C, Henesian M, Heninger J, Henrikson J, Henry EA, Herbold EB, Hermann MR, Hermes G, Hernandez JE, Hernandez VJ, Herrmann MC, Herrmann HW, Herrera OD, Hewett D, Hibbard R, Hicks DG, Higginson DP, Hill D, Hill K, Hilsabeck T, Hinkel DE, Ho DD, Ho VK, Hoffer JK, Hoffman NM, Hohenberger M, Hohensee M, Hoke W, Holdener D, Holdener F, Holder JP, Holko B, Holunga D, Holzrichter JF, Honig J, Hoover D, Hopkins D, Berzak Hopkins LF, Hoppe M, Hoppe ML, Horner J, Hornung R, Horsfield CJ, Horvath J, Hotaling D, House R, Howell L, Hsing WW, Hu SX, Huang H, Huckins J, Hui H, Humbird KD, Hund J, Hunt J, Hurricane OA, Hutton M, Huynh KH, Inandan L, Iglesias C, Igumenshchev IV, Ivanovich I, Izumi N, Jackson M, Jackson J, Jacobs SD, James G, Jancaitis K, Jarboe J, Jarrott LC, Jasion D, Jaquez J, Jeet J, Jenei AE, Jensen J, Jimenez J, Jimenez R, Jobe D, Johal Z, Johns HM, Johnson D, Johnson MA, Gatu Johnson M, Johnson RJ, Johnson S, Johnson SA, Johnson T, Jones K, Jones O, Jones M, Jorge R, Jorgenson HJ, Julian M, Jun BI, Jungquist R, Kaae J, Kabadi N, Kaczala D, Kalantar D, Kangas K, Karasiev VV, Karasik M, Karpenko V, Kasarky A, Kasper K, Kauffman R, Kaufman MI, Keane C, Keaty L, Kegelmeyer L, Keiter PA, Kellett PA, Kellogg J, Kelly JH, Kemic S, Kemp AJ, Kemp GE, Kerbel GD, Kershaw D, Kerr SM, Kessler TJ, Key MH, Khan SF, Khater H, Kiikka C, Kilkenny J, Kim Y, Kim YJ, Kimko J, Kimmel M, Kindel JM, King J, Kirkwood RK, Klaus L, Klem D, Kline JL, Klingmann J, Kluth G, Knapp P, Knauer J, Knipping J, Knudson M, Kobs D, Koch J, Kohut T, Kong C, Koning JM, Koning P, Konior S, Kornblum H, Kot LB, Kozioziemski B, Kozlowski M, Kozlowski PM, Krammen J, Krasheninnikova NS, Krauland CM, Kraus B, Krauser W, Kress JD, Kritcher AL, Krieger E, Kroll JJ, Kruer WL, Kruse MKG, Kucheyev S, Kumbera M, Kumpan S, Kunimune J, Kur E, Kustowski B, Kwan TJT, Kyrala GA, Laffite S, Lafon M, LaFortune K, Lagin L, Lahmann B, Lairson B, Landen OL, Land T, Lane M, Laney D, Langdon AB, Langenbrunner J, Langer SH, Langro A, Lanier NE, Lanier TE, Larson D, Lasinski BF, Lassle D, LaTray D, Lau G, Lau N, Laumann C, Laurence A, Laurence TA, Lawson J, Le HP, Leach RR, Leal L, Leatherland A, LeChien K, Lechleiter B, Lee A, Lee M, Lee T, Leeper RJ, Lefebvre E, Leidinger JP, LeMire B, Lemke RW, Lemos NC, Le Pape S, Lerche R, Lerner S, Letts S, Levedahl K, Lewis T, Li CK, Li H, Li J, Liao W, Liao ZM, Liedahl D, Liebman J, Lindford G, Lindman EL, Lindl JD, Loey H, London RA, Long F, Loomis EN, Lopez FE, Lopez H, Losbanos E, Loucks S, Lowe-Webb R, Lundgren E, Ludwigsen AP, Luo R, Lusk J, Lyons R, Ma T, Macallop Y, MacDonald MJ, MacGowan BJ, Mack JM, Mackinnon AJ, MacLaren SA, MacPhee AG, Magelssen GR, Magoon J, Malone RM, Malsbury T, Managan R, Mancini R, Manes K, Maney D, Manha D, Mannion OM, Manuel AM, Manuel MJ, Mapoles E, Mara G, Marcotte T, Marin E, Marinak MM, Mariscal DA, Mariscal EF, Marley EV, Marozas JA, Marquez R, Marshall CD, Marshall FJ, Marshall M, Marshall S, Marticorena J, Martinez JI, Martinez D, Maslennikov I, Mason D, Mason RJ, Masse L, Massey W, Masson-Laborde PE, Masters ND, Mathisen D, Mathison E, Matone J, Matthews MJ, Mattoon C, Mattsson TR, Matzen K, Mauche CW, Mauldin M, McAbee T, McBurney M, Mccarville T, McCrory RL, McEvoy AM, McGuffey C, Mcinnis M, McKenty P, McKinley MS, McLeod JB, McPherson A, Mcquillan B, Meamber M, Meaney KD, Meezan NB, Meissner R, Mehlhorn TA, Mehta NC, Menapace J, Merrill FE, Merritt BT, Merritt EC, Meyerhofer DD, Mezyk S, Mich RJ, Michel PA, Milam D, Miller C, Miller D, Miller DS, Miller E, Miller EK, Miller J, Miller M, Miller PE, Miller T, Miller W, Miller-Kamm V, Millot M, Milovich JL, Minner P, Miquel JL, Mitchell S, Molvig K, Montesanti RC, Montgomery DS, Monticelli M, Montoya A, Moody JD, Moore AS, Moore E, Moran M, Moreno JC, Moreno K, Morgan BE, Morrow T, Morton JW, Moses E, Moy K, Muir R, Murillo MS, Murray JE, Murray JR, Munro DH, Murphy TJ, Munteanu FM, Nafziger J, Nagayama T, Nagel SR, Nast R, Negres RA, Nelson A, Nelson D, Nelson J, Nelson S, Nemethy S, Neumayer P, Newman K, Newton M, Nguyen H, Di Nicola JG, Di Nicola P, Niemann C, Nikroo A, Nilson PM, Nobile A, Noorai V, Nora RC, Norton M, Nostrand M, Note V, Novell S, Nowak PF, Nunez A, Nyholm RA, O'Brien M, Oceguera A, Oertel JA, Oesterle AL, Okui J, Olejniczak B, Oliveira J, Olsen P, Olson B, Olson K, Olson RE, Opachich YP, Orsi N, Orth CD, Owen M, Padalino S, Padilla E, Paguio R, Paguio S, Paisner J, Pajoom S, Pak A, Palaniyappan S, Palma K, Pannell T, Papp F, Paras D, Parham T, Park HS, Pasternak A, Patankar S, Patel MV, Patel PK, Patterson R, Patterson S, Paul B, Paul M, Pauli E, Pearce OT, Pearcy J, Pedretti A, Pedrotti B, Peer A, Pelz LJ, Penetrante B, Penner J, Perez A, Perkins LJ, Pernice E, Perry TS, Person S, Petersen D, Petersen T, Peterson DL, Peterson EB, Peterson JE, Peterson JL, Peterson K, Peterson RR, Petrasso RD, Philippe F, Phillion D, Phipps TJ, Piceno E, Pickworth L, Ping Y, Pino J, Piston K, Plummer R, Pollack GD, Pollaine SM, Pollock BB, Ponce D, Ponce J, Pontelandolfo J, Porter JL, Post J, Poujade O, Powell C, Powell H, Power G, Pozulp M, Prantil M, Prasad M, Pratuch S, Price S, Primdahl K, Prisbrey S, Procassini R, Pruyne A, Pudliner B, Qiu SR, Quan K, Quinn M, Quintenz J, Radha PB, Rainer F, Ralph JE, Raman KS, Raman R, Rambo PW, Rana S, Randewich A, Rardin D, Ratledge M, Ravelo N, Ravizza F, Rayce M, Raymond A, Raymond B, Reed B, Reed C, Regan S, Reichelt B, Reis V, Reisdorf S, Rekow V, Remington BA, Rendon A, Requieron W, Rever M, Reynolds H, Reynolds J, Rhodes J, Rhodes M, Richardson MC, Rice B, Rice NG, Rieben R, Rigatti A, Riggs S, Rinderknecht HG, Ring K, Riordan B, Riquier R, Rivers C, Roberts D, Roberts V, Robertson G, Robey HF, Robles J, Rocha P, Rochau G, Rodriguez J, Rodriguez S, Rosen MD, Rosenberg M, Ross G, Ross JS, Ross P, Rouse J, Rovang D, Rubenchik AM, Rubery MS, Ruiz CL, Rushford M, Russ B, Rygg JR, Ryujin BS, Sacks RA, Sacks RF, Saito K, Salmon T, Salmonson JD, Sanchez J, Samuelson S, Sanchez M, Sangster C, Saroyan A, Sater J, Satsangi A, Sauers S, Saunders R, Sauppe JP, Sawicki R, Sayre D, Scanlan M, Schaffers K, Schappert GT, Schiaffino S, Schlossberg DJ, Schmidt DW, Schmit PF, Smidt JM, Schneider DHG, Schneider MB, Schneider R, Schoff M, Schollmeier M, Schroeder CR, Schrauth SE, Scott HA, Scott I, Scott JM, Scott RHH, Scullard CR, Sedillo T, Seguin FH, Seka W, Senecal J, Sepke SM, Seppala L, Sequoia K, Severyn J, Sevier JM, Sewell N, Seznec S, Shah RC, Shamlian J, Shaughnessy D, Shaw M, Shaw R, Shearer C, Shelton R, Shen N, Sherlock MW, Shestakov AI, Shi EL, Shin SJ, Shingleton N, Shmayda W, Shor M, Shoup M, Shuldberg C, Siegel L, Silva FJ, Simakov AN, Sims BT, Sinars D, Singh P, Sio H, Skulina K, Skupsky S, Slutz S, Sluyter M, Smalyuk VA, Smauley D, Smeltser RM, Smith C, Smith I, Smith J, Smith L, Smith R, Smith R, Schölmerich M, Sohn R, Sommer S, Sorce C, Sorem M, Soures JM, Spaeth ML, Spears BK, Speas S, Speck D, Speck R, Spears J, Spinka T, Springer PT, Stadermann M, Stahl B, Stahoviak J, Stanley J, Stanton LG, Steele R, Steele W, Steinman D, Stemke R, Stephens R, Sterbenz S, Sterne P, Stevens D, Stevers J, Still CH, Stoeckl C, Stoeffl W, Stolken JS, Stolz C, Storm E, Stone G, Stoupin S, Stout E, Stowers I, Strauser R, Streckart H, Streit J, Strozzi DJ, Stutz J, Summers L, Suratwala T, Sutcliffe G, Suter LJ, Sutton SB, Svidzinski V, Swadling G, Sweet W, Szoke A, Tabak M, Takagi M, Tambazidis A, Tang V, Taranowski M, Taylor LA, Telford S, Theobald W, Thi M, Thomas A, Thomas CA, Thomas I, Thomas R, Thompson IJ, Thongstisubskul A, Thorsness CB, Tietbohl G, Tipton RE, Tobin M, Tomlin N, Tommasini R, Toreja AJ, Torres J, Town RPJ, Townsend S, Trenholme J, Trivelpiece A, Trosseille C, Truax H, Trummer D, Trummer S, Truong T, Tubbs D, Tubman ER, Tunnell T, Turnbull D, Turner RE, Ulitsky M, Upadhye R, Vaher JL, VanArsdall P, VanBlarcom D, Vandenboomgaerde M, VanQuinlan R, Van Wonterghem BM, Varnum WS, Velikovich AL, Vella A, Verdon CP, Vermillion B, Vernon S, Vesey R, Vickers J, Vignes RM, Visosky M, Vocke J, Volegov PL, Vonhof S, Von Rotz R, Vu HX, Vu M, Wall D, Wall J, Wallace R, Wallin B, Walmer D, Walsh CA, Walters CF, Waltz C, Wan A, Wang A, Wang Y, Wark JS, Warner BE, Watson J, Watt RG, Watts P, Weaver J, Weaver RP, Weaver S, Weber CR, Weber P, Weber SV, Wegner P, Welday B, Welser-Sherrill L, Weiss K, Wharton KB, Wheeler GF, Whistler W, White RK, Whitley HD, Whitman P, Wickett ME, Widmann K, Widmayer C, Wiedwald J, Wilcox R, Wilcox S, Wild C, Wilde BH, Wilde CH, Wilhelmsen K, Wilke MD, Wilkens H, Wilkins P, Wilks SC, Williams EA, Williams GJ, Williams W, Williams WH, Wilson DC, Wilson B, Wilson E, Wilson R, Winters S, Wisoff PJ, Wittman M, Wolfe J, Wong A, Wong KW, Wong L, Wong N, Wood R, Woodhouse D, Woodruff J, Woods DT, Woods S, Woodworth BN, Wooten E, Wootton A, Work K, Workman JB, Wright J, Wu M, Wuest C, Wysocki FJ, Xu H, Yamaguchi M, Yang B, Yang ST, Yatabe J, Yeamans CB, Yee BC, Yi SA, Yin L, Young B, Young CS, Young CV, Young P, Youngblood K, Yu J, Zacharias R, Zagaris G, Zaitseva N, Zaka F, Ze F, Zeiger B, Zika M, Zimmerman GB, Zobrist T, Zuegel JD, and Zylstra AB

Abstract

On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a previous NIF implosion [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys. Rev. Lett. 129, 075001 (2022)PRLTAO0031-900710.1103/PhysRevLett.129.075001]. This achievement is the culmination of more than five decades of research and gives proof that laboratory fusion, based on fundamental physics principles, is possible. This Letter reports on the target, laser, design, and experimental advancements that led to this result.

Published
2024
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26. Methotrexate binding to human plasma proteins.

Author

Skibińska L, Ramlau C, Załuski J, and Olejniczak B

Subjects
Antineoplastic Combined Chemotherapy Protocols pharmacology, Humans, Kinetics, Neoplasms blood, Neoplasms drug therapy, Protein Binding, Serum Albumin metabolism, Blood Proteins metabolism, Methotrexate blood
Abstract

The percentage of methotrexate (MTX) binding to plasma protein was 50.4 +/- 1.9 in healthy subject, and 32.3 +/- 3.6 in patients with cancer (breast carcinoma in most cases). Drugs used in combination with MTX in therapy (vincristine, vinblastine, cyclophosphamide, 5-fluorouracil, prednisone) depress the MTX binding to albumins. MTX binds to two kinds of albumins binding sites, with different binding constants: K1 = 8.88 mM-1 and K2 = 1.76 mM-1.

Published
1990

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