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Lung cancer has the highest morbidity rate among all malignant tumors in men and the highest mortality rate in men and women in Russia. In total, 49 145 new cases of lung cancer were registered (diagnosed) in Russia in 2019. The majority of cases are related to exogenic carcinogens and mainly tobacco smoke. For several decades surgical resection with preoperative cytotoxic therapy was an optimal approach for maximal cure rate. This year recommendations were updated with new strategies including adjuvant anti-PD-L1 atezolizumab following completion of chemotherapy in PD-L1 positive patients and osimertinib for EGFR mutated cases. For this moment available data suggest the increase in disease free survival. Strategic approach to treatment for inoperable patients varies according to the status of driver mutations. New approach includes pretreatment option of testing for a wide spectrum of alterations with NGS based panels. Significant changes were incorporated into treatment of ALK mutated NSCLC with two new options of brigatinib for TKI naive patients and lorlatinib for those who progress on second generation drugs. Treatment strategy for patients without activating mutations is based on PD-L1 status. Tsis year recommendations included atezolizumab as a new monotherapy option for patients with high depression of PD-L1. Also treatment options for pembrolizumab, nivolumab and atezolizimab were widened with prolonged treatment schedules.

OBJECTIVE: Conventional thoracoscopy, routinely performed in patients with pleural diseases, is not always conclusive in staging of pleural spread. Fluorescence diagnosis (FD) with 5-aminolaevulinic acid (5-ALA) has been used in the diagnostic purpose for various malignancies. The impact of fluorescence thoracoscopy on diagnosis and staging of pleural malignancies was examined. METHODS: A total of 23 patients with non-conclusive pleural effusions were enrolled in the prospective single-institution trial. Eligible patients were administered 25 mg/kg of 5-ALA (‘Alasense’, Niopik, Russian Federation) per os 3 h before video-assisted thoracoscopy. After conventional inspection with white light, thorough fluorescence investigation of the visceral and parietal pleura was performed (D-LIGHT Auto Fluorescent System, Karl Storz, Germany). Biopsy specimens of both normal and abnormal sites, as determined from white-light and FD inspection, were obtained for histological examination. RESULTS: There was no morbidity or mortality due to the procedure. A definitive diagnosis was obtained in all cases: malignant mesothelioma in 13 cases, other malignancies (pleural metastases) in 8 cases and non-specifi ci n flammation in 3 patients. A total of 118 biopsy specimens were available for histological examination. In 20 patients, all pleural deposits (n= 60) detected by white-light thoracoscopy had bright red fluorescence during FD and were proved to be malignant. Upstaging occurred in 12 patients (57.2%) (unsuspected 21 tumour deposits) due to FD examination. Micrometastases of macroscopically normal pleura were detected, only by FD, in one patient. Comparing the results of histological examination of specimens detected by conventional thoracoscopy with that by fluorescence thoracoscopy, we obtained 82 true positive, 10 false-negative, 23 true negative, 3 false-positive results with a specificity of 88.4%, sensitivity of 89.1% and diagnostic accuracy of 88.9%. CONCLUSIONS: FD using 5-ALA in the pleural cavity is a feasible diagnostic tool when used in addition to white-light thoracoscopy. It improves visualization of additional lesions or even micrometastases in patients with pleural malignancy.