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Hebeloma parvisporum is described as new and placed within H. sect. Porphyrospora. This mushroom is sold as an edible in markets of Laos under the local name “wai khom.” Hebeloma sect. Porphyrospora is discussed and expanded to include the species formerly included in the genus Anamika and recently transferred to Hebeloma. Hebeloma sect. Porphyrospora currently comprises 16 species, 14 of which are known only from the western Pacific and Indian subcontinent. All species in this section share the character of having red-brown spores when fresh, atypical for other sections of Hebeloma, which causes the lamellae to be red-brown. However, this red-brown color fades when the material is dried. The close links, morphologically and molecularly, between H. parvisporum and other members of H. sect. Porphyrospora, particularly H. victoriense, are shown.

A strategy for automatic mesh refinement in limit analysis is combined with a recently developed computational method. In the absence of estimates of the local error the strategy can be based on the deformations and on slack in the yield condition. The approach is tested on standard problems in plane strain, including the classical punch problem. Very accurate results are obtained with the use of moderate computational power.

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are promising drugs for the treatment of HIV when used in combination with other anti-HIV drugs such as nucleoside reverse transcriptase (RT) inhibitors and protease inhibitors. The first generation of NNRTIs have, however, suffered from the rapid development of resistance. This review discusses the properties of the FDA-approved NNRTI drugs and focuses on the recent efforts being made to produce second generation inhibitors that circumvent this resistance problem.

New S-DABOs with a long alkylating S-alkyl substituent showing antiretroviral activity against HIV-1 in the micromolar range were prepared from 5,6-disubstituted 4-oxo-2-thiopyrimidines and 1,7-dibromo-3,5-dioxaheptane. The analogues with an ethyl group in position 5 also showed activity in the micromolar range against a Tyr/8/Cys mutant strain of HIV-1. The S-DABO analogues showing activity against the HIV-1 RT mutant strain were transformed to the N-3 and N-1 ring closed 7-oxo-pyrimidino-1,3,5-oxathiazepines which surprisingly all showed activity against HIV-1 in the micromolar range, as well as against a Tyr/8/Cys mutant strain of HIV-1. Some analogues of S-DABO with a thien-2-ylmethyl residue in position 6 were synthesized and tested against HIV-1 wild type, but they showed less or comparable activities to those of the corresponding 6-benzyl analogues.

Fully automated synthesis of branched oligodeoxynucleotides (branched ODNs) has been accomplished using 2′-O-levulinyl- or 5′-O-levulinyl-protected arabino-uridine derivatives as branching monomers. Selective removal of the levulinyl groups is accomplished using 0.5 M hydrazine hydrate in a pyridine–acetic acid–water (4∶3∶0.35, v/v/v) buffer. The affinity of the branched ODNs towards complementary DNA has been evaluated at 260 nm and 284 nm during thermal denaturing experiments. Enhanced affinity of a branched ODN compared with the corresponding linear reference is attributed to bimolecular triple helix formation.

Four new genera encompassing six new species are described in the Lyophyllaceae (Agaricales): the monotypic Australocybe from Australia; the monotypic Phaeotephrocybe from Belize; the monotypic Nigrocarnea from Laos containing the novel conidia-producing species N. radicata and Praearthromyces containing two Asian taxa, the conidia-producing P. corneri known from Malaysia and Singapore and P. griseus from Thailand, which lacks conidial production. In addition, we describe Arthromyces glabriceps, which is the first species in the genus Arthromyces that lacks conidial production on the basidiome. Alternative options for a classification of these lyophylloid taxa are discussed and based on morphological, ecological and biogeographical considerations rejected.