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2. Evolving treatment implementation among HIV- infected pregnant women and their partners: Results from a national surveillance study in Italy, 2001-2015

Author

Floridia, M, Frisina, V, Ravizza, M, Marconi, A, Pinnetti, C, Cetin, I, Sansone, M, Molinari, A, Cervi, F, Meloni, A, Luzi, K, Masuelli, G, Tamburrini, E, Ensoli, B, Moroni, M, Lazzarin, A, Sagnelli, E, Antinori, A, Carosi, G, Marcotullio, S, Mazzotta, F, Vella, S, Ammassari, A, Antonucci, G, Andreoni, M, Angarano, G, Armignacco, O, Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Cattelan, A, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, Cinque, P, d'Arminio Monforte, A, De Carli, G, De Luca, A, Di Perri, G, Di Pietro, M, El Hamad, I, Errico, M, Ferrazzi, E, Gabrielli, E, Galli, M, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Liuzzi, G, Lo Caputo, S, Maggiolo, F, Malena, M, Maserati, R, Mastroianni, C, Matteelli, A, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Palu, G, Pempinello, R, Perno, C, Prestileo, T, Pompa, M, Puoti, M, Puro, V, Rancilio, L, Rasi, G, Rizzardini, G, Savasi, V, Signorini, L, Sighinolfi, L, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Suter, F, Tambussi, G, Tavio, M, Torti, C, Tozzi, V, Trotta, M, Vaccher, E, Vigano, A, Visintini, R, Vullo, V, Zuccotti, G, Dell'Isola, S, Manfredini, V, Parisi, S, Pezzoli, M, Zona, S, Floridia M., Frisina V., Ravizza M., Marconi A. M., Pinnetti C., Cetin I., Sansone M., Molinari A., Cervi F., Meloni A., Luzi K., Masuelli G., Tamburrini E., Ensoli B., Moroni M., Lazzarin A., Sagnelli E., Antinori A., Carosi G., Marcotullio S., Mazzotta F., Vella S., Ammassari A., Antonucci G., Andreoni M., Angarano G., Armignacco O., Babudieri S., Baldelli F., Bini T., Bonfanti P., Bonora S., Borderi M., Bruno R., Bucciardini R., Castagna A., Cattelan A. M., Cauda R., Cerioli A., Chirianni A., Cingolani A., Cinque P., d'Arminio Monforte A., De Carli G., De Luca A., Di Perri G., Di Pietro M., El Hamad I., Errico M., Ferrazzi E., Gabrielli E., Galli M., Giaquinto C., Girardi E., Gori A., Grossi P., Guaraldi G., Liuzzi G., Lo Caputo S., Maggiolo F., Malena M., Maserati R., Mastroianni C., Matteelli A., Morrone A., Murri R., Mussini C., Nasta P., Oldrini M., Oleari F., Orlando G., Palu G., Pempinello R., Perno C. -F., Prestileo T., Pompa M. G., Puoti M., Puro V., Rancilio L., Rasi G., Rizzardini G., Savasi V. M., Signorini L., Sighinolfi L., Stagnitta M., Starace F., Starnini G., Sterrantino G., Suter F., Tambussi G., Tavio M., Torti C., Tozzi V., Trotta M. P., Vaccher E., Vigano A., Visintini R., Vullo V., Zuccotti G. V., Dell'Isola S., Manfredini V., Parisi S., Pezzoli M. C., Zona S., Floridia, M, Frisina, V, Ravizza, M, Marconi, A, Pinnetti, C, Cetin, I, Sansone, M, Molinari, A, Cervi, F, Meloni, A, Luzi, K, Masuelli, G, Tamburrini, E, Ensoli, B, Moroni, M, Lazzarin, A, Sagnelli, E, Antinori, A, Carosi, G, Marcotullio, S, Mazzotta, F, Vella, S, Ammassari, A, Antonucci, G, Andreoni, M, Angarano, G, Armignacco, O, Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Cattelan, A, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, Cinque, P, d'Arminio Monforte, A, De Carli, G, De Luca, A, Di Perri, G, Di Pietro, M, El Hamad, I, Errico, M, Ferrazzi, E, Gabrielli, E, Galli, M, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Liuzzi, G, Lo Caputo, S, Maggiolo, F, Malena, M, Maserati, R, Mastroianni, C, Matteelli, A, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Palu, G, Pempinello, R, Perno, C, Prestileo, T, Pompa, M, Puoti, M, Puro, V, Rancilio, L, Rasi, G, Rizzardini, G, Savasi, V, Signorini, L, Sighinolfi, L, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Suter, F, Tambussi, G, Tavio, M, Torti, C, Tozzi, V, Trotta, M, Vaccher, E, Vigano, A, Visintini, R, Vullo, V, Zuccotti, G, Dell'Isola, S, Manfredini, V, Parisi, S, Pezzoli, M, Zona, S, Floridia M., Frisina V., Ravizza M., Marconi A. M., Pinnetti C., Cetin I., Sansone M., Molinari A., Cervi F., Meloni A., Luzi K., Masuelli G., Tamburrini E., Ensoli B., Moroni M., Lazzarin A., Sagnelli E., Antinori A., Carosi G., Marcotullio S., Mazzotta F., Vella S., Ammassari A., Antonucci G., Andreoni M., Angarano G., Armignacco O., Babudieri S., Baldelli F., Bini T., Bonfanti P., Bonora S., Borderi M., Bruno R., Bucciardini R., Castagna A., Cattelan A. M., Cauda R., Cerioli A., Chirianni A., Cingolani A., Cinque P., d'Arminio Monforte A., De Carli G., De Luca A., Di Perri G., Di Pietro M., El Hamad I., Errico M., Ferrazzi E., Gabrielli E., Galli M., Giaquinto C., Girardi E., Gori A., Grossi P., Guaraldi G., Liuzzi G., Lo Caputo S., Maggiolo F., Malena M., Maserati R., Mastroianni C., Matteelli A., Morrone A., Murri R., Mussini C., Nasta P., Oldrini M., Oleari F., Orlando G., Palu G., Pempinello R., Perno C. -F., Prestileo T., Pompa M. G., Puoti M., Puro V., Rancilio L., Rasi G., Rizzardini G., Savasi V. M., Signorini L., Sighinolfi L., Stagnitta M., Starace F., Starnini G., Sterrantino G., Suter F., Tambussi G., Tavio M., Torti C., Tozzi V., Trotta M. P., Vaccher E., Vigano A., Visintini R., Vullo V., Zuccotti G. V., Dell'Isola S., Manfredini V., Parisi S., Pezzoli M. C., and Zona S.

Abstract

Background The current global and national indications for antiretroviral treatment (ART, usually triple combination therapy) in adolescent and adults, including pregnant women, recommend early ART before immunologic decline, pre-exposure chemoprophylaxis (PrEP), and treatment of HIV-negative partners in serodiscordant couples. There is limited information on the implementation of these recommendations among pregnant women with HIV and their partners. Methods The present analysis was performed in 2016, using data from clinical records of pregnant women with HIV, followed between 2001 and 2015 at hospital or university clinics within a large, nationally representative Italian cohort study. The study period was divided in three intervals of five years each (2001-2005, 2006-2010, 2011-2015), and the analysis evaluated temporal trends in rates of HIV diagnosis in pregnancy, maternal antiretroviral treatment at conception, prevalence of HIV infection among partners of pregnant women with HIV, and proportion of seronegative and seropositive male partners receiving antiretroviral treatment. Results The analysis included 2755 pregnancies in women with HIV. During the three time intervals considered the rate of HIV diagnosis in pregnancy (overall 23.3%), and the distribution of HIV status among male partners (overall 48.7% HIV- negative, 28.6% HIV-positive and 22.8% unknown) remained substantially unchanged. Significant increases were observed in the proportion of women with HIV diagnosed before pregnancy who were on antiretroviral treatment at conception (from 62.0% in 2001-2005 to 81.3% in 2011-2015, P < 0.001), and in the proportion of HIV-positive partners on antiretroviral treatment (from 73.3% in 2001-2005 to 95.8% in 2011-2015, P = 0.002). Antiretroviral treatment was administered in 99.1% of the pregnancies that did not end early because of miscarriage, termination, or intrauterine death, and in 75.3% of those not ending in a live birth. No implementation of antir

Published
2017

3. Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. Update 2016

Author

Antinori, Andrea, Di Biagio, Antonio, Marcotullio, Simone, Andreoni, Massimo, Chirianni, Antonio, d'Arminio Monforte, Antonella, Galli, Massimo, Mazzotta, Francesco, Mussini, Cristina, Puoti, Massimo, Lazzarin, Adriano, Matteelli, Alberto, Andreoni, M, Chirianni, A, Antinori, A, Galli, M, Lazzarin, A, d'Arminio Monforte, A, Di Perri, G, Perno, Cf, Puoti, M, Vella, S, Di Biagio, A, Marcotullio, S, Ammassari, A, Angarano, G, Armignacco, O, Babudieri, S, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Breveglieri, M, Calza, L, Capobianchi, Mr, Cagarelli, R, Calcagno, A, Castagna, A, Castelli, F, Cattelan, Am, Cauda, R, Cingolani, A, Cinque, P, Corbelli, Gm, D'Ettorre, G, De Carli, G, De Luca, A, Di Pietro, M, El Hamad, I, Errico, M, Gaeta, Gb, Gargiulo, M, Gervasoni, C, Giacomet, V, Giannini, A, Gianotti, N, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Lichtner, M, Liuzzi, G, Lo Caputo, S, Maggi, P, Maggiolo, F, Marchetti, G, Maserati, R, Mastroianni, C, Matteelli, A, Mazzotta, F, Menichetti, F, Mussini, C, Nozza, S, Oldrini, M, Parruti, G, Pascucci, Mg, Parrella, R, Prestileo, T, Puro, V, Rancilio, L, Marina, R, Rezza, G, Rizzardini, G, Rusconi, S, Santoro, M, Sighinolfi, L, Stagnitta, M, Starnini, G, Tamburrini, E, Tambussi, G, Tavio, M, Torti, C, Vaccher, E, Viscoli, C, Visintini, R, Vullo, V, Zaccarelli, M, Zuccotti, Gv., Antinori, Andrea, Di Biagio, Antonio, Marcotullio, Simone, Andreoni, Massimo, Chirianni, Antonio, Antonella, Galli, Massimo, Mazzotta, Francesco, Mussini, Cristina, Puoti, Massimo, Lazzarin, Adriano, Italian Hiv Guidelines Working, Group, and Castagna, Antonella

Subjects
Settore MED/17 - Malattie Infettive, Anti-HIV Agents, Health Policy, Antiretroviral agents, Guidelines, HIV, Italy, Anti-HIV Agent, HIV Infections, Guideline, antiretroviral agents, Drug Administration Schedule, Drug Therapy, Combination, HIV-1, Practice Guidelines as Topic, Drug Therapy, antiretroviral agent, Combination, HIV Infection
Abstract

The Italian Society of Infectious and Tropical Diseases (SIMIT) of the Technical Health Committee, Ministry of Health (Sections L and M) of Italy have supported recommendations for the Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. This publication summarizes the latest updates to the 2016 version of the Italian Guidelines for the management of HIV-1 infected patients and the use of antiretroviral drugs. In particular, new recommendations were released concerning the following topics: estimate of the HIV continuum of care in Italy, optimal timing and preferred drug combinations for starting antiretroviral therapy, treatment optimization, and pre-exposure prophilaxis (PrEP). For a complete review of clinical and therapeutic relevant topics we refer the reader to the extended version of the Guidelines.

Published
2017

4. Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. Update 2011

Author

Antinori A, Marcotullio S, Ammassari A, Andreoni M, Angarano G, Armignacco O, Carosi G, Cinque P, d'Arminio Monforte A, Di Perri G, Ensoli B, Floridia M, Galli M, Mastroianni C, Matteelli A, Mazzotta F, Moroni M, Palù G, Puoti M, Puro V, Rizzardini G, Sagnelli E, Vella S, Vullo V, Lazzarin A Collaborators (88) Ensoli B, Lazzarin A, Babudieri S, Baldelli F, Bini T, Bonfanti P, Bonora S, Borderi M, Bruno R, Bucciardini R, Castagna A, Castelli F, Cattelan AM, Cauda R, Cerioli A, Chirianni A, Cingolani A, Monforte Ad, De Carli G, De Luca A, Di Pietro M, El Hamad I, Errico M, Filice G, Gabrielli E, Gaeta G. B., Gervasoni C, Giacomet V, Giaquinto C, Girardi E, Gori A, Grossi P, Guaraldi G, Liuzzi G, Caputo SL, Maggi P, Maggiolo F, Malena M, Maserati R, Morrone A, Murri R, Mussini C, Nasta P, Oldrini M, Oleari F, Orlando G, Pali G, Perno CF, Prestileo T, Pompa MG, Rancilio L, Ravizza M, Savasi VM, Signorini L, Sighinolfi L, Stagnitta M, Starace F, Starnini G, Sterrantino G, Tamburrini E, Tambussi G, Tavio M, Torti C, Tozzi V, Trotta MP, Vaccher E, Visintini R, Zuccotti V., Antinori, A, Marcotullio, S, Ammassari, A, Andreoni, M, Angarano, G, Armignacco, O, Carosi, G, Cinque, P, d'Arminio Monforte, A, Di Perri, G, Ensoli, B, Floridia, M, Galli, M, Mastroianni, C, Matteelli, A, Mazzotta, F, Moroni, M, Palù, G, Puoti, M, Puro, V, Rizzardini, G, Sagnelli, E, Vella, S, Vullo, V, Lazzarin, A Collaborators (88) Ensoli B, Lazzarin, A, Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Castelli, F, Cattelan, Am, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, Monforte, Ad, De Carli, G, De Luca, A, Di Pietro, M, El Hamad, I, Errico, M, Filice, G, Gabrielli, E, Gaeta, G. B., Gervasoni, C, Giacomet, V, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Liuzzi, G, Caputo, Sl, Maggi, P, Maggiolo, F, Malena, M, Maserati, R, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Pali, G, Perno, Cf, Prestileo, T, Pompa, Mg, Rancilio, L, Ravizza, M, Savasi, Vm, Signorini, L, Sighinolfi, L, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Tamburrini, E, Tambussi, G, Tavio, M, Torti, C, Tozzi, V, Trotta, Mp, Vaccher, E, Visintini, R, and Zuccotti, V.

Published
2012

5. Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. Update December 2014

Author

Antinori, A, Marcotullio, S, Andreoni, M, Ammassari, A, d'Arminio Monforte, A, Galli, M, Girardi, Enrico, Mazzotta, F, Mussini, C, Puoti, M, Lazzarin, A, Angarano, G, Armignacco, O, Babudieri, S, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Breveglieri, M, Bruno, R, Capobianchi, Mr, Cagarelli, R, Calcagno, A, Castagna, A, Castelli, F, Cattelan, Am, Cauda, R, Cerioli, A, Chirianni, A, Cinque, P, Corbelli, Gm, D'Ettorre, G, De Carli, G, De Luca, A, Di Biagio, A, Di Perri, G, Di Pietro, M, El Hamad, I, Errico, M, Finarelli Alba, C, Gaeta, Gb, Gervasoni, C, Giacomet, V, Gianotti, N, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Ivanovic, J, Lichtner, M, Liuzzi, G, Lo Caputo, S, Maggi, P, Maggiolo, F, Malena, M, Marchetti, G, Maserati, R, Mastroianni, C, Matteelli, Alberto, Nicastri, E, Nozza, S, Oldrini, M, Pascucci, Mg, Perno, Cf, Prestileo, T, Puro, V, Rancilio, L, Ravizza, M, Rizzardini, G, Rusconi, S, Santoro, M, Sighinolfi, L, Stagnitta, M, Starnini, G, Tamburrini, E, Tambussi, G, Tavio, M, Torti, C, Viscoli, C, Visintini, R, Vullo, V, Zaccarelli, M, and Zuccotti, G. v.

Subjects
Italy, Anti-HIV Agents, HIV-1, Humans, HIV Infections
Published
2015

6. Italian HIV GuidelinesWorking Group. Italian guidelines for the use of antiretroviral agents and thediagnostic-clinical management of HIV-1 infected persons. Update 2011

Author

Antinori, A, Marcotullio, S, Ammassari, A, Andreoni, M, Angarano, G, Armignacco, O, Carosi, G, Cinque, P, d'Arminio Monforte, A, Di Perri, G, Ensoli, B, Floridia, M, Galli, M, Mastroianni, C, Matteelli, A, Mazzotta, F, Moroni, M, Pal, G, Puoti, M, Puro, V, Rizzardini, G, Sagnelli, E, Vella, S, Vullo, V, Lazzarin, A, Collaborators: Ensoli B, Italian HIV Guidelines Working G. r. o. u. p., Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Castelli, F, Cattelan, Am, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, Monforte, Ad, De Carli, G, De Luca, A, Di Pietro, M, El Hamad, I, Errico, M, Filice, G, Gabrielli, E, Gaeta, Gb, Gervasoni, C, Giacomet, V, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Liuzzi, G, Caputo, Sl, Maggi, P, Maggiolo, F, Malena, M, Maserati, R, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Pali, G, Perno, Cf, Prestileo, T, Pompa, Mg, Rancilio, L, Ravizza, M, Savasi, Vm, Signorini, L, Sighinolfi, L, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Tamburrini, E, Tambussi, G, Tavio, M, Torti, Carlo, Tozzi, V, Trotta, Mp, Vaccher, E, Visintini, R, and Zuccotti, V.

Published
2012

7. Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons

Author

Antinori, A, Marcotullio, S, Ammassari, A, Andreoni, M, Angarano, G, Carosi, G, Cinque, P, D' Arminio Monforte, A, Di Perri, G, Ensoli, B, Ferrazzi, E, Galli, M, Mastroianni, C, Matteelli, A, Mazzotta, F, Moroni, M, Pal, G, Puoti, M, Puro, V, Rizzardini, G, Sagnelli, E, Suter, F, Vella, S, Collaborators: Ensoli B, Lazzarin A., Lazzarin, A, Antonucci, G, Armignacco, O, Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Cattelan, Am, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, De Carli, G, De Luca, A, Di Pietro, M, El Hamad, I, Errico, M, Floridia, M, Gabrielli, E, Giaquinto, C, Girardi, E, Gori, A, Grossi, PAOLO ANTONIO, Guaraldi, G, Liuzzi, G, Lo Caputo, S, Maggiolo, F, Malena, M, Maserati, R, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Pempinello, R, Perno, Cf, Prestileo, T, Pompa, Mg, Rancilio, L, Rasi, G, Savasi, Vm, Signorini, L, Sighinolfi, L, Sighinolfi, M, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Tamburini, E, Tambussi, G, Tavio, M, Torti, C, Tozzi, V, Trotta, Mp, Vaccher, E, Vigan, A, Visintini, R, Vullo, V, Zuccotti, Gv, Antinori, A, Marcotullio, S, Ammassari, A, Andreoni, M, Angarano, G, Carosi, G, Cinque, P, d'Arminio Monforte, A, Di Perri, G, Ensoli, B, Ferrazzi, E, Galli, M, Mastroianni, C, Matteelli, A, Mazzotta, F, Moroni, M, Palù, G, Puoti, M, Puro, V, Rizzardini, G, Sagnelli, E, Suter, F, Vella, S, Lazzarin, A, Gori, A, Antinori, Andrea, Marcotullio, Simone, Ammassari, Adriana, Andreoni, Massimo, Angarano, Gioacchino, Carosi, Giampiero, Cinque, Paola, Monforte Antonella, D'Arminio, Di Perri, Giovanni, Ensoli, Barbara, Ferrazzi, Enrico, Galli, Massimo, Mastroianni, Claudio, Matteelli, Alberto, Mazzotta, Francesco, Moroni, Mauro, Palu, Giorgio, Puoti, Massimo, Puro, Vincenzo, Rizzardini, Giuliano, Sagnelli, Evangelista, Suter, Fredy, Vella, Stefano, and for the Italian HIV Guidelines Working, Group

Subjects
ACTIVE ANTIRETROVIRAL THERAPY, HIV, Guidelines, Antiretroviral therapy, Anti-HIV Agents, Anti-HIV Agent, HIV Infections, HIV infection, Settore MED/07 - Microbiologia e Microbiologia Clinica, Italy, therapeutic use, HIV Infections, diagnosis/drug therapy/immunology, HIV-1, drug effects/immunology, Italy, diagnosis/drug therapy/immunology, therapeutic use, HIV-1, guidelines, drug effects/immunology
Published
2011

8. Time to Linkage to Care (LtC) in the ICONA Cohort: 2010-2018

Author

Pierluca Piselli, Tavelli, A., Cimaglia, C., Chiaradia, G., Rancilio, L., Oldrini, M., Congolani, A., Quiros Roldan, M. E., Rizzo, V., Rusconi, S., Caraglia, A., D’arminio Monforte, A., Girardi, E., Nunnari, G., and Pellicano, Giovanni Francesco

Subjects
28+or+>60+days%29+in+the+last+three+years+%282016-2018%29+of+enrolment%22">A timely linkage to care (LtC) after HIV diagnosis may benefit individual health and may reduce onward transmission of HIV. We determined the time from HIV diagnosis to LtC among persons with HIV (PWH) entering HIV care and enrolled in the ICONA cohort in 2010-2018. We also analysed determinants for a late LtC (>28 or >60 days) in the last three years (2016-2018) of enrolment

9. Evolving treatment implementation among HIV- infected pregnant women and their partners: Results from a national surveillance study in Italy, 2001-2015

Author

Floridia, M., Frisina, V. b., Ravizza, M., Marconi, A. M., Pinnetti, C., Cetin, I., Sansone, M., Molinari, A., Cervi, F., Meloni, A., Luzi, K., Masuelli, G., Tamburrini, E., Ensoli, B., Moroni, M., Lazzarin, A., Sagnelli, E., Antinori, A., Carosi, G., Marcotullio, S., Mazzotta, F., Vella, S., Ammassari, A., Antonucci, G., Andreoni, M., Angarano, G., Armignacco, O., Babudieri, S., Baldelli, F., Bini, T., Bonfanti, Bonora, P., Borderi, S., Bruno, M., Bucciardini, R., Castagna, R, Cattelan, A., Cauda, A. M., Cerioli, R., Chirianni, A., Cingolani, A., Cinque, A., D'Arminio, Monforte, Carli, De, Luca, De, Perri, Di, Pietro, Di, Hamad, El, Errico, I., Ferrazzi, M., Gabrielli, E., Galli, E., Giaquinto, M., Girardi, C., Gori, E., Grossi, A., Guaraldi, P., Liuzzi, G., Caputo, Lo, Maggiolo, S., Malena, F., Maserati, M., Mastroianni, R., Matteelli, C., Morrone, A., Murri, A., Mussini, R., Nasta, C., Oldrini, P., Oleari, M., Orlando, F., Palù, G., Pempinello, G., Perno, R., Prestileo, C., Pompa, T., Puoti, M. G., Puro, M., Rancilio, V., Rasi, L., Rizzardini, G., Savasi, G., Signorini, V. M., Sighinolfi, L., Stagnitta, L., Starace, M., Starnini, F., Sterrantino, G., Suter, G., Tambussi, F., Tavio, G., Torti, M., Tozzi, C., Trotta, V., Vaccher, M. P., Viganò, E., Visintini, A., Vullo, R., Zuccotti, V., Dell'Isola, G. V., Manfredini, S., Parisi, V., Pezzoli, S., M. C., Floridia, M, Frisina, V, Ravizza, M, Marconi, A, Pinnetti, C, Cetin, I, Sansone, M, Molinari, A, Cervi, F, Meloni, A, Luzi, K, Masuelli, G, Tamburrini, E, Ensoli, B, Moroni, M, Lazzarin, A, Sagnelli, E, Antinori, A, Carosi, G, Marcotullio, S, Mazzotta, F, Vella, S, Ammassari, A, Antonucci, G, Andreoni, M, Angarano, G, Armignacco, O, Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Cattelan, A, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, Cinque, P, d'Arminio Monforte, A, De Carli, G, De Luca, A, Di Perri, G, Di Pietro, M, El Hamad, I, Errico, M, Ferrazzi, E, Gabrielli, E, Galli, M, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Liuzzi, G, Lo Caputo, S, Maggiolo, F, Malena, M, Maserati, R, Mastroianni, C, Matteelli, A, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Palu, G, Pempinello, R, Perno, C, Prestileo, T, Pompa, M, Puoti, M, Puro, V, Rancilio, L, Rasi, G, Rizzardini, G, Savasi, V, Signorini, L, Sighinolfi, L, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Suter, F, Tambussi, G, Tavio, M, Torti, C, Tozzi, V, Trotta, M, Vaccher, E, Vigano, A, Visintini, R, Vullo, V, Zuccotti, G, Dell'Isola, S, Manfredini, V, Parisi, S, Pezzoli, M, Zona, S, Floridia, M., Frisina, V., Ravizza, M., Marconi, A. M., Pinnetti, C., Cetin, I., Sansone, M., Molinari, A., Cervi, F., Meloni, A., Luzi, K., Masuelli, G., Tamburrini, E., Ensoli, B., Moroni, M., Lazzarin, A., Sagnelli, E., Antinori, A., Carosi, G., Marcotullio, S., Mazzotta, F., Vella, S., Ammassari, A., Antonucci, G., Andreoni, M., Angarano, G., Armignacco, O., Babudieri, S., Baldelli, F., Bini, T., Bonfanti, P., Bonora, S., Borderi, M., Bruno, R., Bucciardini, R., Castagna, A., Cattelan, A. M., Cauda, R., Cerioli, A., Chirianni, A., Cingolani, A., Cinque, P., d'Arminio Monforte, A., De Carli, G., De Luca, A., Di Perri, G., Di Pietro, M., El Hamad, I., Errico, M., Ferrazzi, E., Gabrielli, E., Galli, M., Giaquinto, C., Girardi, E., Gori, A., Grossi, P., Guaraldi, G., Liuzzi, G., Lo Caputo, S., Maggiolo, F., Malena, M., Maserati, R., Mastroianni, C., Matteelli, A., Morrone, A., Murri, R., Mussini, C., Nasta, P., Oldrini, M., Oleari, F., Orlando, G., Palu, G., Pempinello, R., Perno, C. -F., Prestileo, T., Pompa, M. G., Puoti, M., Puro, V., Rancilio, L., Rasi, G., Rizzardini, G., Savasi, V. M., Signorini, L., Sighinolfi, L., Stagnitta, M., Starace, F., Starnini, G., Sterrantino, G., Suter, F., Tambussi, G., Tavio, M., Torti, C., Tozzi, V., Trotta, M. P., Vaccher, E., Vigano, A., Visintini, R., Vullo, V., Zuccotti, G. V., Dell'Isola, S., Manfredini, V., Parisi, S., Pezzoli, M. C., and Zona, S.

Subjects
0301 basic medicine, Male, Infectious Disease Transmission, HIV Infections, Pre-Exposure Prophylaxi, Miscarriage, Cohort Studies, Pre-exposure prophylaxis, 0302 clinical medicine, Pregnancy, Prevalence, Medicine, Vertical, HIV Infection, 030212 general & internal medicine, Pregnancy Complications, Infectious, Treatment implementation, Obstetrics, Health Policy, Medicine (all), Infectious, Pregnancy Outcome, Articles, 3. Good health, Sexual Partner, Sexual Partners, Italy, Serodiscordant, Chemoprophylaxis, Female, Live birth, Adolescent, Adult, Anti-HIV Agents, Fertilization, Humans, Infectious Disease Transmission, Vertical, Pre-Exposure Prophylaxis, Cohort study, Human, medicine.medical_specialty, 03 medical and health sciences, Environmental health, business.industry, Public Health, Environmental and Occupational Health, Anti-HIV Agent, medicine.disease, 030112 virology, Pregnancy Complications, Pregnancy Complications, Infectiou, Cohort Studie, business
Abstract

Background The current global and national indications for antiretroviral treatment (ART, usually triple combination therapy) in adolescent and adults, including pregnant women, recommend early ART before immunologic decline, pre-exposure chemoprophylaxis (PrEP), and treatment of HIV-negative partners in serodiscordant couples. There is limited information on the implementation of these recommendations among pregnant women with HIV and their partners. Methods The present analysis was performed in 2016, using data from clinical records of pregnant women with HIV, followed between 2001 and 2015 at hospital or university clinics within a large, nationally representative Italian cohort study. The study period was divided in three intervals of five years each (2001-2005, 2006-2010, 2011-2015), and the analysis evaluated temporal trends in rates of HIV diagnosis in pregnancy, maternal antiretroviral treatment at conception, prevalence of HIV infection among partners of pregnant women with HIV, and proportion of seronegative and seropositive male partners receiving antiretroviral treatment. Results The analysis included 2755 pregnancies in women with HIV. During the three time intervals considered the rate of HIV diagnosis in pregnancy (overall 23.3%), and the distribution of HIV status among male partners (overall 48.7% HIV- negative, 28.6% HIV-positive and 22.8% unknown) remained substantially unchanged. Significant increases were observed in the proportion of women with HIV diagnosed before pregnancy who were on antiretroviral treatment at conception (from 62.0% in 2001-2005 to 81.3% in 2011-2015, P < 0.001), and in the proportion of HIV-positive partners on antiretroviral treatment (from 73.3% in 2001-2005 to 95.8% in 2011-2015, P = 0.002). Antiretroviral treatment was administered in 99.1% of the pregnancies that did not end early because of miscarriage, termination, or intrauterine death, and in 75.3% of those not ending in a live birth. No implementation of antiretroviral treatment was introduced among male HIV-negative partners. Conclusions The results suggest good implementation of antiretroviral treatment among HIV-positive women and their HIV-positive partners, but no implementation, even in recent years, of Pre-Exposure Prophylaxis (PrEP) among uninfected male partners. Further studies should assess the determinants of this occurrence and clarify the attitudes and the potential barriers to PrEP use.

Published
2017

10. HIV rapid testing in community and outreach sites: results of a nationwide demonstration project in Italy.

Author

Scognamiglio P, Chiaradia G, Giovanetti M, Albertini E, Camposeragna A, Farinella M, Lorenzetti D, Oldrini M, Rancilio L, Caraglia A, Maraglino FP, Ippolito G, and Girardi E

Subjects
Adult, Feasibility Studies, Female, Humans, Italy, Male, Middle Aged, Community Health Centers, Community-Institutional Relations, HIV Infections diagnosis, Mass Screening methods
Abstract

Background: Globally the access to HIV testing has greatly increased over the past 30 years. Nonetheless, a high proportion of people living with HIV remains undiagnosed, even in resource rich countries. To increase the proportion of people aware of their HIV serostatus and their access to medical care, several strategies have been proposed including HIV rapid test programs offered outside health facilities. The aim of this project was to evaluate the feasibility and efficacy of the HIV rapid testing offered in community and outreach settings in Italy., Methods: We conducted a national demonstration project on HIV rapid tests offered in community and outreach settings, including nongovernmental organization (NGO) facilities, primary care services for migrants and low-threshold services or mobile units for drug users (DU services). HIV rapid test on oral fluid (OraQuick®; Orasure Technologies) was anonymously offered to eligible people who presented themselves at the selected sites. Those with reactive results were referred to a specialized outpatient unit for confirmatory testing and medical care., Results: Over a period of six months a total of 2949 tests were performed and 45.2% of individuals tested had not been previously tested. Overall 0.9% (27/2949) of tested people had a preliminary positive test. In NGO facilities the positivity rate was 1%. All subjects who performed their confirmatory test were confirmed as positive. In services for migrants the positivity rate was 0.5 and 80% were referred to care (with 1 false positive test). In DU services we observed the highest positivity rate (1.4%) but the lowest linkage to care (67%), with 1 false positive test., Conclusion: Our project showed that the offering of an HIV rapid testing program in community and outreach settings in Italy is feasible and that it may reach people who have never been tested before, while having a significant yield in terms of new HIV diagnoses as well.

Published
2018
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11. PEP and TasP Awareness among Italian MSM, PLWHA, and High-Risk Heterosexuals and Demographic, Behavioral, and Social Correlates.

Author

Prati G, Zani B, Pietrantoni L, Scudiero D, Perone P, Cosmaro L, Cerioli A, and Oldrini M

Subjects
Adolescent, Adult, Cross-Sectional Studies, Female, HIV isolation & purification, HIV Infections diagnosis, HIV Infections epidemiology, Health Knowledge, Attitudes, Practice, Heterosexuality, Homosexuality, Male, Humans, Italy epidemiology, Male, Middle Aged, Patient Education as Topic, Social Stigma, Socioeconomic Factors, Unsafe Sex, Young Adult, HIV Infections prevention & control, HIV Infections transmission, Post-Exposure Prophylaxis methods
Abstract

Post-exposure prophylaxis (PEP) has been proposed as a strategy to prevent the acquisition of HIV infection after certain high-risk exposures, and treatment as prevention (TasP) is also being advocated as a means to reduce sexual transmission of HIV. The aim of this study was to investigate the prevalence of PEP and TasP awareness and their demographic, behavioral, and social correlates in Italy. We conducted a cross-sectional survey of 1,028 high-risk heterosexual men and women, 1,874 non-HIV positive MSM (men who have sex with men), and 694 people living with HIV/AIDS (PLWHA). The majority of the participants was aware of PEP and unaware of TasP. MSM were less knowledgeable about PEP and TasP than were PLWHA and more knowledgeable about PEP and TasP than were high-risk heterosexual participants. The variables most consistently associated with PEP and TasP awareness were contact with HIV/AIDS organizations, HIV testing, and HIV stigma. A positive relationship between unprotected sexual intercourse and PEP and TasP awareness was found among high risk heterosexual participants, while this association was not significant among MSM and PLWHA. Because PEP and TasP are currently recommended, effective educational and dissemination strategies are needed to increase the level of knowledge about PEP and TasP.

Published
2016
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12. Psychometric Properties of a New HIV/AIDS Knowledge Measure for Adults.

Author

Prati G, Zani B, Pietrantoni L, Scudiero D, Perone P, Cosmaro L, Cerioli A, and Oldrini M

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Condoms statistics & numerical data, Female, Heterosexuality psychology, Heterosexuality statistics & numerical data, Homosexuality, Male psychology, Homosexuality, Male statistics & numerical data, Humans, Italy, Male, Middle Aged, Psychometrics, Reproducibility of Results, Sexual Partners, Social Stigma, Young Adult, HIV Infections psychology, Health Knowledge, Attitudes, Practice, Surveys and Questionnaires
Abstract

The aim of this study was to develop a new 29-item HIV/AIDS knowledge measure and to examine its psychometric properties for three samples of adults: non-HIV-positive heterosexual people, non-HIV-positive men who have sex with men (MSM), and people living with HIV/AIDS (PLWHA). The authors collected data using an online questionnaire. A total of 9,349 Italian individuals agreed to participate in the study: 694 individuals (7.4%) were PLWHA, 5,232 (56.0%) were HIV negative, and the remaining 3,423 (36.6%) were MSM. Using two-parameter item response theory analysis, a bifactor model was found to be better fitting than a one-factor model or a 12 correlated first-order factor model. Differential item functioning showed evidence of measurement nonequivalence of the instrument for the three samples of adults. The reliability of HIV/AIDS knowledge scale among PLWHA was satisfactory. Criterion-related validity was only achieved among non-HIV-positive heterosexual people, non-HIV-positive MSM, as the HIV/AIDS knowledge scale was related with attitudes toward condom use, condom use with casual partners, unknown HIV status of partner, and HIV stigma. Among non-HIV-positive heterosexual people, the HIV/AIDS knowledge scale adds to the prediction of condom use above that of attitudes toward condom use scale. The HIV/AIDS knowledge scale is especially discriminating at low to medium levels of knowledge.

Published
2016
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