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2. Current state and advances in desensitization for peanut allergy in pediatric age.

Author

Foti Randazzese, Simone, Panasiti, Ilenia, Caminiti, Lucia, Catamerò, Francesco, Landi, Massimo, De Filippo, Maria, Votto, Martina, Olcese, Roberta, Favuzza, Filippo, Giovannini, Mattia, and Barberi, Salvatore

Subjects
ALLERGY desensitization, PEANUT allergy, SUBLINGUAL immunotherapy, CHILD patients, LACTOBACILLUS rhamnosus
Abstract

Peanut allergy affects about 1%–3% of the pediatric population in the world, with an important increase in the last decades. Nowadays, international guidelines recommend the early introduction of peanuts in the infant diet, with poor information about the quantity and the frequency of the intake. Allergen immunotherapy may represent the only therapeutic strategy able to modify the natural history of peanut allergy. In particular, oral immunotherapy showed the most promising results in terms of efficacy, but with significant rates of adverse reactions, mostly gastrointestinal. In 2020, the Food and Drug Administration and the European Medicines Agency approved Palforzia®, an oral drug for patients aged 4–17 years. Several studies are ongoing to improve the tolerability of oral immunotherapy and standardize the desensitization protocols. Sublingual immunotherapy permits to offer much lower doses than oral immunotherapy, but fewer adverse events are shown. Subcutaneous immunotherapy is associated with the greatest systemic adverse effects. Epicutaneous immunotherapy, for which Viaskin® patch was approved, has the highest safety profile. Innovative studies are evaluating the use of biological drugs, such as omalizumab or dupilumab, and probiotics, such as Lactobacillus rhamnosus, in monotherapy or associated with oral immunotherapy. Therapy for peanut allergy is constantly evolving, and new perspectives are ongoing to develop. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Omalizumab and allergen immunotherapy for respiratory allergies

Author

De Filippo, Maria, primary, Votto, Martina, additional, Caminiti, Lucia, additional, Carella, Francesco, additional, De Castro, Giovanna, additional, Landi, Massimo, additional, Olcese, Roberta, additional, Panasiti, Ilenia, additional, Vernich, Mario, additional, Barberi, Salvatore, additional, Ciprandi, Giorgio, additional, and Marseglia, Gian Luigi, additional

Published
2022
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7. Safety of allergen‐specific immunotherapy in children

Author

De Filippo, Maria, primary, Votto, Martina, additional, Caminiti, Lucia, additional, Panasiti, Ilenia, additional, Carella, Francesco, additional, De Castro, Giovanna, additional, Landi, Massimo, additional, Olcese, Roberta, additional, Vernich, Mario, additional, Marseglia, Gian Luigi, additional, Ciprandi, Giorgio, additional, and Barberi, Salvatore, additional

Published
2022
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8. The challenge of asthma control grading in clinical practice

Author

Anastasio, Elisa, Caffarelli, Carlo, Caricato, Federica, Chini, Loredana, Del Duca, Elisabetta, De Vittori, Valentina, Di Cicco, Maria Elisa, Kantar, Ahmad, Leone, Maddalena, Licari, Amelia, Moschese, Viviana, Olcese, Roberta, Peroni, Diego G., Talarico, Valeria, Votto, Martina, Tosca, Maria Angela, Schiavetti, Irene, and Ciprandi, Giorgio

Published
2021
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9. Glycyrrhetic Acid Exerts Positive Effects on Nasal Symptoms and Asthma Control in Allergic Children.

Author

Tosca, Maria Angela, Olcese, Roberta, Salmaso, Claudia, Damiani, Valerio, and Ciprandi, Giorgio

Subjects
ALLERGY in children, IMMUNOGLOBULIN E, ASTHMA prevention, ANTI-inflammatory agents, VISUAL analog scale, MANNITOL
Abstract

Objective: Allergic rhinitis and asthma share an immunoglobulin E-mediated inflammatory reaction following exposure to the causal allergen. Asthma control is associated with rhinitis control. Glycyrrhetic acid is extracted from the licorice and has an anti-inflammatory property. Mannitol is an anti-edema molecule. A medical device contains these components. This study evaluated the medical device efficacy on symptoms and asthma control in children with allergic rhinitis and mild controlled asthma. Methods: The children took 2 puffs of the medical device for each nostril twice a day for 4 weeks. Symptom severity was evaluated considering the total symptom score and nasal obstruction. Symptom perception was assessed by children and doctors using the visual analog scale. Asthma severity and control were also evaluated. Parents judged the efficacy. Results: The study included 38 children: 18 (47.4%) females and 20 (52.6%) males; the mean age was 10.2 (±2.15) years. The treatment significantly reduced the severity of all symptoms, including nasal obstruction (P < .001). Both children and doctors perceived a reduction of symptom intensity (P < .001). Parents judged the treatment as effective. Asthma remained mild and controlled. Conclusions: This pilot study, conducted in clinical practice, showed that intranasal glycyrrhetic acid plus mannitol could reduce nasal symptoms, including obstruction, and maintain asthma control. Therefore, this multicomponent medical device could represent a potential option in children with allergic rhinitis and mild controlled asthma. [ABSTRACT FROM AUTHOR]

Published
2022
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10. The challenge of asthma control grading in clinical practice

Author

Tosca, Maria Angela, primary, Schiavetti, Irene, additional, Ciprandi, Giorgio, additional, Anastasio, Elisa, additional, Caffarelli, Carlo, additional, Caricato, Federica, additional, Chini, Loredana, additional, Del Duca, Elisabetta, additional, De Vittori, Valentina, additional, Di Cicco, Maria Elisa, additional, Kantar, Ahmad, additional, Leone, Maddalena, additional, Licari, Amelia, additional, Moschese, Viviana, additional, Olcese, Roberta, additional, Peroni, Diego G., additional, Talarico, Valeria, additional, and Votto, Martina, additional

Published
2021
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12. Allergen immunotherapy in children and adolescents with respiratory diseases

Author

Tosca, Maria Angela, Licari, Amelia, Olcese, Roberta, Castagnoli, Riccardo, Marseglia, Alessia, Marseglia, Gian Luigi, Miraglia del Giudice, Michele, Martelli, Alberto, Calvani, Mauro, Caffarelli, Carlo, Duse, Marzia, Cravidi, Claudio, Cardinale, Fabio, and Ciprandi, Giorgio

Subjects
Adolescent, allergen-specific immunotherapy, Review, Respiration Disorders, Rhinitis, Allergic, sublingual immunotherapy, Asthma, respiratory tract diseases, children, immune system diseases, subcutaneous immunotherapy, Desensitization, Immunologic, Quality of Life, Humans, Child, allergic asthma
Abstract

To date, the only disease-modifying treatment strategy for allergic rhinitis and asthma is allergen immunotherapy (AIT). There is evidence that AIT improves allergic rhinitis and asthma, such as reducing symptom severity and medication use and improving of quality of life, with a long-lasting effect after the end of the course. The recent clinical trials evidenced AIT effectiveness and safety in allergic asthma. Consequently, the current version of the GINA (Global Initiative for Asthma) guidelines recommend AIT as an add-on therapy for asthma. There is also evidence that AIT may exert preventive activity on the possible progression from allergic rhinitis to asthma in children and the onset of new sensitizations. (www.actabiomedica.it)

Published
2020

13. ControL'Asma Project: new insights

Author

Tosca, Maria Angela, Licari, Amelia, Pistorio, Angela, Marseglia, Gian Luigi, Ciprandi, Giorgioe, Anastasio, Elisa, Brambilla, Ilaria, Caffarelli, Carlo, Chini, Loredana, Ciprandi, Riccardo, De Vittori, Valentina, Duse, Marzia, Di Cicco, Maria Elisa, Indinnimeo, Luciana, Kantar, Ahmad, Leone, Maddalena, Moschese, Viviana, Olcese, Roberta, Peroni, Diego G, Salmaso, Claudia, Silvestri, Michela Silvestri, and Zicari, Anna Maria

Subjects
Male, Allergy, medicine.medical_specialty, adolescents, asthma, asthma control, children, lung function, respiratory symptoms, VAS, Immunology, Comorbidity, Asthma management, Very frequent, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, Hypersensitivity, medicine, Humans, Immunology and Allergy, 030212 general & internal medicine, Child, Rhinitis, Asthma, Early onset, business.industry, Asthma symptoms, medicine.disease, Rhinitis, Allergic, Settore MED/38, respiratory tract diseases, Italy, 030228 respiratory system, Family medicine, Pediatrics, Perinatology and Child Health, Pediatric allergy, business
Abstract

The Italian Society of Paediatric Allergy and Immunology has developed the project "ControL'Asma," a nationwide study involved ten third-level pediatric allergy clinics across Italy. The first findings of the "ControL'Asma" project showed that asthma was more frequent in males, had an early onset and allergic phenotype with very frequent rhinitis comorbidity, uncontrolled, and partly controlled asthma affected about the half of subjects, and the assessment of asthma symptom perception by VAS could be a reliable tool in the asthma management.

Published
2020

14. Asthma in children and adolescents: the ControL'Asma project

Author

Licari, Amelia, Ciprandi, Giorgio, Marseglia, Gian Luigi, Silvestri, Michela, Tosca, Maria Angela, Anastasio, Elisa, Brambilla, Ilaria, Caffarelli, Carlo, Castagnoli, Riccardo, Chini, Loredana, Ciprandi, Riccardo, De Vittori, Valenina, Duse, Marzia, Di Cicco, Maria Elisa, Indinnimeo, Lucian, Kantar, Ahmad, Leone, Maddalena, Marinelli, Guido, Moschese, Viviana, Olcese, Roberta, Peroni, Diego G, Pistorio, Angela, Salmaso, Claudia, and Zicari, Anna Maria

Subjects
Male, Adolescent, respiratory symptoms, lung function, asthma, asthma control, children, adolescents, VAS, Comorbidity, Review, Settore MED/38, respiratory tract diseases, Italy, Adolescents, Asthma, Asthma control, Children, Lung function, Respiratory symptoms, immune system diseases, Hypersensitivity, Humans, Child, Rhinitis
Abstract

The control of asthma is the objective of asthma management. However, it is difficult to obtain in clinical practice. The Italian Society of Allergy and Clinical Immunology promoted the nationwide project “ControL’Asma” to investigate the real situation in a group of children and adolescents with asthma. The preliminary outcomes demonstrated that many asthmatic subjects do not achieve adequate asthma control. Moreover, asthma in Italian children and adolescents was usually more frequent in males, had an early onset and allergic phenotype with very frequent rhinitis comorbidity, uncontrolled and partly controlled asthma affected about the half of subjects. However, this project suggested that the assessment of asthma symptom perception by VAS could be a reliable tool in the asthma management. (www.actabiomedica.it)

Published
2020

18. The practical clinical relevance of rhinitis classification in children with asthma: outcomes of the “ControL’Asma” study

Author

Anastasio, Elisa, Brambilla, Ilaria, Caffarelli, Carlo, Chini, Loredana, Ciprandi, Riccardo, Del Barba, Paolo, De Vittori, Valentina, Di Cicco, Maria Elisa, Indinnimeo, Luciana, Kantar, Ahmad, Leone, Maddalena, Licari, Amelia, Moschese, Viviana, Olcese, Roberta, Peroni, Diego, Pistorio, Angela, Silvestri, Michela, Zicari, Anna Maria, Tosca, Maria Angela, Duse, Marzia, Marseglia, Gianluigi, and Ciprandi, Giorgio

Published
2019
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26. The practical clinical relevance of rhinitis classification in children with asthma

Author

Tosca, Maria Angela, primary, Duse, Marzia, additional, Marseglia, Gianluigi, additional, Ciprandi, Giorgio, additional, Anastasio, Elisa, additional, Brambilla, Ilaria, additional, Caffarelli, Carlo, additional, Chini, Loredana, additional, Ciprandi, Riccardo, additional, Del Barba, Paolo, additional, De Vittori, Valentina, additional, Di Cicco, Maria Elisa, additional, Indinnimeo, Luciana, additional, Kantar, Ahmad, additional, Leone, Maddalena, additional, Licari, Amelia, additional, Moschese, Viviana, additional, Olcese, Roberta, additional, Peroni, Diego, additional, Pistorio, Angela, additional, Silvestri, Michela, additional, and Zicari, Anna Maria, additional

Published
2019
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27. Immunotherapy and Asthma in Children

Author

Tosca, Maria A., primary, Licari, Amelia, additional, Olcese, Roberta, additional, Marseglia, Gianluigi, additional, Sacco, Oliviero, additional, and Ciprandi, Giorgio, additional

Published
2018
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28. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016

Author

Pouessel, Guillaume, Claverie, Claire, Labreuche, Julien, Renaudin, Jean-Marie, Dorkenoo, Aimée, Eb, Mireille, Moneret-Vautrin, Anne, Deschildre, Antoine, Leteurtre, Stephane, Grabenhenrich, Linus, Worm, Margitta, Dölle, Sabine, Scherer, Kathrin, Hutteger, Isidor, Christensen, Morten, Bindslev-Jensen, Carsten, Mortz, Charlotte, Eller, Esben, Kjaer, Henrik F, Carneiro-Leão, Leonor, Badas, Jenny, Coimbra, Alice, Levy, Dikla P, Ben-Shoshan, Moshe, Rimon, Ayelet, Benor, Shira, Arends, Nicolette J T, Edelbroek, Nikki, de Groot, Hans, Emons, Joyce A M, Brand, H. K A, Verhoeven, Dirk, van Veen, Leonieke N, de Jong, Nicolette W, Noh, Geunwoong, Jang, Eun H, Pascal, Mariona, Dominguez, Olga, Piquer, Mònica, Alvaro, Montserrat, Jimenez-Feijoo, Rosa, Lozano, Jaime, Machinena, Adriana, del Mar Folqué, Maria, Giner, Maria T, Plaza, Ana M, Turner, Paul, Patel, Nandinee, Vazquez-Ortiz, Marta, Lindsley, Sarah, Walker, Lucy, Rosenberg, Simon, Mari, Adriano, Alessandri, Claudia, Giangrieco, Ivana, Tuppo, Lisa, Rafaiani, Chiara, Mitterer, Georg, Ciancamerla, Michela, Ferrara, Rosetta, Bernardi, Maria L, Zennaro, Danila, Tamburrini, Maurizio, Ciardiello, Maria A, Harwanegg, Christian, Fernandez, Antonio, Selb, Regina, Egenmann, Philippe, Epstein, Michelle, Hoffmann-Sommergruber, Karin, Koning, Frits, Lovik, Martinus, Clare Mills, E. N, Moreno, Javier, van Loveren, Henk, Wal, Jean-Michel, Diesner, Susanne, Bergmayr, Cornelia, Pfitzner, Barbara, Assmann, Vera E, Starkl, Philipp, Endesfelder, David, Eiwegger, Thomas, Szepfalusi, Zsolt, Fehrenbach, Heinz, Jensen-Jarolim, Erika, Hartmann, Anton, Pali-Schöll, Isabella, Untersmayr, Eva, Wille, Soren, Meyer, Peter, Klingebiel, Caroline, Lidholm, Jonas, Ehrenberg, Angelica, Östling, Jonas, Cleach, Isabelle, Mège, Jean-Louis, Vitte, Joana, Aina, Roberta, Dubiela, Pawel, Pfeifer, Sabine, Bublin, Merima, Radauer, Christian, Humeniuk, Piotr, Kabasser, Stefan, Asero, Riccardo, Bogas, Gador, Gomez, Francisca, Campo, Paloma, Salas, Maria, Doña, Inmaculada, Barrionuevo, Esther, Guerrero, Maria A, Mayorga, Cristobalina, Prieto, Ana, Barber, Domingo, Torres, Maria J, Jamin, Annette, Wangorsch, Andrea, Ballmer, Barbara, Vieths, Stefan, Scheurer, Stephan, Apostolovic, Danijela, Mihailovic, Jelena, Krstic, Maja, Starkhammar, Maria, Velickovic, Tanja C, Hamsten, Carl, van Hage, Marianne, van Erp, Francine C, Knol, Edward F, Kansen, Hannah M, Pontoppidan, Bo, Meijer, Yolanda, van der Ent, Cornelis K, Knulst, André C, Sayers, Rebekah, Brown, Helen, Custovic, Adnan, Simpson, Angela, Mills, Claire, Schulz, Juliane, Akkerdaas, Jaap, Totis, Muriel, Capt, Annabelle, Herouet-Guicheney, Corinne, van Ree, Ronald, Banerjee, Tushar, Banerjee, Antima, Claude, Mathilde, Bouchaud, Grégory, Lupi, Roberta, Castan, Laure, Tranquet, Olivier, Denery-Papini, Sandra, Bodinier, Marie, Brossard, Chantal, De Poi, Rosella, Gritti, Elisa, De Dominicis, Emiliano, Popping, Bert, de Laureto, Patrizia P, Palosuo, Kati, Kukkonen, Anna K, Pelkonen, Anna, Mäkelä, Mika, Lee, Nanju A, Rost, Johanna, Muralidharan, Sridevi, Campbell, Dianne, Mehr, Sam, Nock, Catherine, Baumert, Joseph, Taylor, Steve, Mastrorilli, Carla, Tripodi, Salvatore, Caffarelli, Carlo, Perna, Serena, Di Rienzo Businco, Andrea, Sfika, Ifigenia, Dondi, Arianna, Bianchi, Annamaria, Dascola, Carlotta P, Ricci, Giampaolo, Cipriani, Francesca, Maiello, Nunzia, del Giudice, Michele M, Frediani, Tullio, Frediani, Simone, Macrì, Francesco, Pistoletti, Chiara, Iacono, Iride D, Patria, Maria F, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Olcese, Roberta, Moretti, Matteo, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, Verga, Maria C, Calvani, Mauro, Giordani, Paolo, Matricardi, Paolo M, Ontiveros, Noe, Cabrera-Chavez, Francisco, Galand, Julie, Beaudouin, Etienne, Pineau, Florence, Sakai, Shinobu, Matsunaga, Kayoko, Teshima, Reiko, Larré, Colette, Denery, Sandra, Tschirner, Sebastian, Trendelenburg, Valérie, Schulz, Gabriele, Niggemann, Bodo, Beyer, Kirsten, Bouferkas, Youcef, Belabbas, Younes, Saidi, Djamel, Kheroua, Omar, Mecherfi, Kamel E E, Guendouz, Malika, Haddi, Abir, Kaddouri, Hanane, Amaral, Luis, Pereira, Ana, Rodrigues, Susana, Datema, Mareen, Jongejan, Laurian, Clausen, Michael, Knulst, Andre, Papadopoulos, Nikolaos, Kowalski, Marek, de Blay, Frédéric, Zwinderman, Aeilko, Hoffman-Sommergruber, Karin, Ballmer-Weber, Barbara, Fernandez-Rivas, Montserrat, Deng, Shan, Yin, Jia, Eisenmann, Charlotte, Nassiri, Maria, Reinert, Rabea, van der Valk, Johanna P M, van Wijk, Roy G, Vergouwe, Yvonne, Steyerberg, Ewout W, Reitsma, Marit, Wichers, Harry J, Savelkoul, Huub F J, Vlieg-Boerstra, Berber, Dubois, Anthony E J, Carolino, Fabrícia, Rodolfo, Ana, Cernadas, Josefina, Roa-Medellín, Dasha, Rodriguez-Fernandez, Ana, Navarro, Joaquín, Albendiz, Vicente, Baeza, María L, Intente-Herrero, Sonsoles, Mikkelsen, Andrea, Mehlig, Kirsten, Lissner, Lauren, Verrill, Linda, Luccioli, Stefano, van Bilsen, Jolanda, Kuper, Frieke, Wolterbeek, André, Rankouhi, Tanja R, Verschuren, Lars, Cnossen, Hilde, Jeurink, Prescilla, Garssen, Johan, Knippels, Léon, Garthoff, Jossie, Houben, Geert, Leeman, Winfried, Eleonore Pettersson, M., Schins, Afke M M, Koppelman, Gerard H, Kollen, Boudewjin J, Zubchenko, Svitlana, Kuntz, Sarah, Mérida, Pablo, Álvaro, Montserrat, Piquer, Monica, Riggioni, Carmen, Castellanos, Juan H, Jimenez, Rosa, Cap, Melanie, Drumez, Elodie, Lejeune, Stéphanie, Thumerelle, Caroline, Mordacq, Clémence, Nève, Véronique, Ricò, Sonia, Varini, Margherita, Nocerino, Rita, Cosenza, Linda, Amoroso, Antonio, Di Costanzo, Margherita, Di Scala, Carmen, Bedogni, Giorgio, Canani, Roberto B, Turner, Paul J, Poza-Guedes, Paloma, González-Pérez, Ruperto, Sánchez-Machín, Inmaculada, Matheu-Delgado, Victor, Wambre, Erik, Ballegaard, Anne-Sofie, Madsen, Charlotte, Gregersen, Juliane, Bøgh, Katrine L, Aubert, Philippe, Neunlist, Michel, Magnan, Antoine, Lozano-Ojalvo, Daniel, Pablos-Tanarro, Alba, Pérez-Rodríguez, Leticia, Molina, Elena, López-Fandiño, Rosina, Rekima, Akila, Macchiaverni, Patricia, Turfkruyer, Mathilde, Holvoet, Sebastien, Dupuis, Lénaïck, Baiz, Nour, Annesi-Maesano, Isabella, Mercenier, Annick, Nutten, Sophie, Verhasselt, Valérie, Mrakovcic-Sutic, Ines, Banac, Srdan, Sutic, Ivana, Baricev-Novakovic, Zdenka, Sutic, Ingrid, Pavisic, Valentino, Muñoz-Cano, Rosa, Jiménez-Rodríguez, Teodoríkez, Corbacho, Daniel, Roca-Ferrer, Jordi, Bartra, Joan, Bulog, Aleksandar, Micovic, Vladimir, Markiewicz, Lidia, Szymkiewicz, Agata, Szyc, Anna, Wróblewska, Barbara, Harvey, Bryan M, Harthoorn, Lucien F, Wesley Burks, A., Rentzos, Georgios, Björk, Anna-Lena B, Bengtsson, Ulf, Barber, Colin, Kalicinsky, Chrystyna, Breynaert, Christine, Coorevits, Lieve, Jansen, Cornelia, Van Hoeyveld, Erna, Verbeke, Kristin, Kochuyt, Anne-Marie, Schrijvers, Rik, Deleanu, Diana, Muntean, Adriana, Konstantakopoulou, Maria, Pasioti, Maria, Papadopoulou, Anastasia, Iliopoulou, Anna, Mikos, Nikolaos, Kompoti, Evangelia, de Castro, Eunice D, Bartalomé, Borja, Ue, Kok L, Griffiths, Elizabeth, Till, Stephen, Grimshaw, Kate, Roberts, Graham, Selby, Anna, Butiene, Indre, Larco, Jose I, Dubakiene, Ruta, Fiandor, Ana, Fiocchi, Alessandro, Papadopoulos, Nikos, Sigurdardottir, Sigurveig, Sprikkelman, Aline, Schoemaker, Anne-Fleur, Xepapadaki, Paraskevi, Keil, Thomas, Cojocariu, Zizi, Barbado, Beatriz S, Iancu, Vasti, Arroabarren, Esozia, Esarte, Marta G, Arteaga, Miren, Andrade, Mayra C, Borges, Denise, Kalil, Jorge, Bianchi, Pedro G, Agondi, Rosana C, Gupta, Rinkesh K, Sharma, Akanksha, Gupta, Kriti, Das, Mukul, Dwivedi, Premendra, Karseladze, Rusudan, Jorjoliani, Liana, Saginadze, Lali, Tskhakaia, Mariam, Basello, Katia, Piuri, Gabriele, Speciani, Attilio F, Speciani, Michela C, Camerotto, Carla, Zinno, Francesco, Pakholchuk, Olga, Nedelska, Svitlana, Pattini, Stefano, Costantino, Maria T, Peveri, Silvia, Villalta, Danilo, Savi, Eleonora, Costanzi, Andrea, Revyakina, Vera A, Kiseleva, Marina A, Kuvshinova, Elena D, Larkova, Inna A, Shekhetov, Anton A, Silva, Diana, Moreira, André, Plácido, José, van der Kleij, Hanneke, van Twuijver, Esther, Sutorius, Robbert, de Kam, Pieter-Jan, van Odijk, Jenny, Lindqvist, Helen, Lustig, Elin, Jácome, Amyra A A, Aguilar, Karla L B, Domínguez, Miguel G, Hernández, David A M, Caruso, Cristiano, Casale, Cono, Rapaccini, Gian L, Romano, Antonino, De Vitis, Italo, Cocco, Renata R, Aranda, Carolina, Mallozi, Marcia C, Motta, Jackeline F, Moraes, Lilian, Pastorino, Antonio, Rosario, Nelson, Goudouris, Ekaterini, Porto, Arnaldo, Wandalsen, Neusa F, Sarinho, Emanuel, Sano, Flavio, Solé, Dirceu, Pitsios, Constantinos, Petrodimopoulou, Maria, Papadopoulou, Ekaterini, Passioti, Maria, Kontogianni, Meropi, Adamia, Nino, Khaleva, Ekaterina, del Prado, Ana P, Du Toit, George, Krzych, Edyta, Samolinska-Zawisza, Urszula, Furmanczyk, Konrad, Tomaszewska, Aneta, Raciborski, Filip, Lipiec, Agnieszka, Samel-Kowalik, Piotr, Walkiewicz, Artur, Borowicz, Jacek, Samolinski, Boleslaw, Nano, Aimee L, Recto, Marysia, Somoza, Maria L, López, Natalia B, Alzate, Diana P, Ruano, Francisco J, Garcimartín, Maria I, Haroun, Elisa, de la Torre, Maria V, Rojas, Antonia, Onieva, Montserrat L, Canto, Gabriela, Rodrigues, Alexandra, Forno, Andreia, Cabral, António J, Gonçalves, Rute, Vorozhko, Ilya, Sentsova, Tatyana, Chernyak, Olga, Denisova, Svetlana, Ilènko, Lidia, Muhortnich, Valery, Zimmermann, Caroline, Rohrbach, Alexander, Bakhsh, Faisal R, Boudewijn, Kollen, Oomkes-Pilon, Anne-Marie, Van Ginkle, Dorien, Šilar, Mira, Jeverica, Anja, Vesel, Tina, Avčin, Tadej, Korošec, Peter, van der Valk, Johanna, Berends, Irene, Arends, Nicolette, van Maaren, Maurits, Wichers, Harry, Emons, Joyce, Dubois, Anthony, de Jong, Nicolette, Matsyura, Oksana, Besh, Lesya, Huang, Chung-Hsiung, Jan, Tong-Rong, Stiefel, Gary, Tratt, Jean, Kirk, Kerrie, Carolino, Fabricia, Arasi, Stefania, Caminiti, Lucia, Crisafulli, Giuseppe, Fiamingo, Chiara, Fresta, Jlenia, Pajno, Giovanni, Remington, Ben, Kruizinga, Astrid, Marty Blom, W., Westerhout, Joost, Bijlsma, Sabina, Baumert, Joe, Blankestijn, Mark, Otten, Henny, Klemans, Rob, Michelsen-Huisman, Anouska D, van Os-Medendorp, Harmieke, Kruizinga, Astrid G, Versluis, Astrid, van Duijn, Gert, de Zeeuw-Brouwer, H. 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Astrid G, Versluis, Astrid, van Duijn, Gert, de Zeeuw-Brouwer, H. M, Castenmiller, Jacqueline J M, Noteborn, Hub P J M, Houben, Geert F, Bravin, Kristian, Luyt, David, Javed, Bushra, Couch, Phil, Munro, Christopher, Padfield, Phil, Sperrin, Matt, Byrne, Aideen, Oosthuizen, Lizalet, Kelleher, Carina, Ward, Fiona, Brosnan, Niamh, King, Graham, Corbet, Eva, Guzmán, Josué A H, García, Montserrat B, Asensio, Oscar, Navarrete, Laura V, Larramona, Helena, Miró, Xavier D, Pyrz, Katarzyna, Austin, Moira, Boloh, Yanne, Couch, Philip, Galloway, Deirdre, Hernandez, Pilar, Hourihane, Jonathan O, Kenna, Fiona, Majkowska-Wojciechowska, Barbara, Regent, Lynne, Themisb, Marina, Schnadt, Sabine, Semic-Jusufagic, Aida, Galvin, Audrey D, Kauppila, Tiina, Kuitunen, Mikael, Kitsioulis, Nikolaos A, Douladiris, Nikolaos, Kostoudi, Sofia, Manolaraki, Ioanna, Mitsias, Dimitris, Manousakis, Emmanouil, Papadopoulos, Nikolaos G, Knibb, Rebecca, Hammond, Jennifer, Cooke, Richard, Yrjänä, Jaakko, Hanni, Anna-Maija, Vähäsarja, Päivi, Mustonen, Oona, Dunder, Teija, Kulmala, Petri, Lasa, Eva, D’Amelio, Carmen, Martínez, Sara, Joral, Alejandro, Gastaminza, Gabriel, Goikoetxea, Maria J, Candy, David C A, Van Ampting, Marleen T J, Oude Nijhuis, Manon M, Butt, Assad M, Peroni, Diego G, Fox, Adam T, Knol, Jan, Michaelis, Louise J, Padua, Ines, Padrao, Patricia, Moreira, Pedro, Barros, Renata, Sharif, Hanan, Ahmed, Manzoor, Gomaa, Nehad, Mens, Joris, Smit, Koen, Timmermans, Frans, Poredoš, Tomaž, Jeverica, Anja K, Sedmak, Marjeta, Benedik, Evgen, Accetto, Meta, Zupančič, Mirjana, Yonamine, Glauce, Soldateli, Gustavo, Aquilante, Bruna, Pastorino, Antonio C, de Moraes Beck, Cleonir L, Gushken, Andrea K, de Barros Dorna, Mayra, dos Santos, Cristiane N, Castro, Ana P M, Al-Qahtani, Abdulhadi, Arnaout, Rand, Khaliq, Agha R, Amin, Rashid, Sheikh, Farrukh, Alvarez, Jorge, Anda, Marta, Palacios, Miriam, De Prada, Montserrat, Ponce, Carmen, Balbino, Bianca, Sibilano, Riccardo, Marichal, Thomas, Gaudenzio, Nicolas, Karasuyama, Hajime, Bruhns, Pierre, Tsai, Mindy, Reber, Laurent L, Galli, Stephen J, Ferreira, Ana R, Cernadas, Josefina R, del Campo García, Aida, Fernández, Sara P, Carrera, Nerea S, Sánchez-Cruz, Fernando B, Lorenzo, José R F, Claus, Stephanie, Pföhler, Claudia, Ruëff, Franziska, Treudler, Regina, Jaume, Mercedes E, Madroñero, Agustin, Perez, Maria T G, Julia, Juan C, Plovdiv, Charlotte H, Gethings, Lee, Langridge, Jim, Adel-Patient, Karine, Bernard, Hervé, Barcievic-Jones, Ivona, Sokolova, Raditsa, Yankova, Rumyana, Ivanovska, Mariya, Murdjeva, Marianna, Popova, Tatyana, Dermendzhiev, Svetlan, Karjalainen, Martin, Lehnigk, Ulrike, Brown, Duncan, Locklear, Julie C, Locklear, Julie, Maris, Ioana, Hourihane, Jonathan, Ornelas, Cristina, Caiado, Joana, Ferreira, Manuel B, Pereira-Barbosa, Manuel, Puente, Yolanda, Daza, Juan C, Monteseirin, Francisco J, Ukleja-Sokolowska, Natalia, Gawronska-Ukleja, Ewa, Zbikowska-Gotz, Magdalena, Bartuzi, Zbigniew, Sokolowski, Lukasz, Adams, Aine, Mahon, Bernard, English, Karen, Gourdon-Dubois, Nelly, Sellam, Laetitia, Pereira, Bruno, Michaud, Elodie, Messaoudi, Khaled, Evrard, Bertrand, Fauquert, Jean-Luc, Palomares, Francisca, Gomez, Gador, Rodriguez, Maria J, Galindo, Luisa, Molina, Ana, Paparo, Lorella, Mennini, Maurizio, Aitoro, Rosita, Wawrzeńczyk, Adam, Przybyszewski, Michał, Wawrzeńczyk, Anna, Sarıcoban, Hulya E, Ugras, Meltem, Yalvac, Zerrin, Flokstra-de Blok, Bertine M J, van der Velde, J. L, Vereda, Andrea, Ippolito, Clara, Traversa, Amaranta, Adriano, Daniela, Bianchi, Daniela M, Gallina, Silvia, Decastelli, Lucia, Makatsori, Melina, Miles, Anne, Devetak, Sonja P, Devetak, Iztok, Tabet, Soraya A, Trandbohus, Jeanette F, Winther, Pernille, Malling, Hans-Jørgen, Hansen, Kirsten S, Garvey, Lene H, Wang, Chia-Chi, Cheng, Yin-Hua, Tung, Chun-Wei, Dietrich, Mariola, Marenholz, Ingo, Kalb, Birgit, Grosche, Sarah, Blümchen, Katharina, Schlags, Rupert, Price, Mareike, Rietz, Sylke, Esparza-Gordillo, Jorge, Lau, Susanne, Lee, Young-Ae, Almontasheri, Ali, Bahkali, Mohammad A, Elshorbagi, Sahar, Alfhaid, Abdullah, Altamimi, Mashary, Madbouly, Eman, Al-Dhekri, Hassan, Arnaout, Rand K, Basagaña, Maria, Miquel, Sira, Bartolomé, Borja, Brix, Bettina, Rohwer, Stefanie, Brandhoff, Sandra, Berger, Alena, Suer, Waltraud, Weimann, Alf, Bueno, Cristina, Martín-Pedraza, Laura, Abián, Sara, Segundo-Acosta, Pablo S, López-Rodríguez, Juan C, Barderas, Rodrigo, Batanero, Eva, Cuesta-Herranz, Javier, Villalba, María T, Correia, Magna, Benito-Garcia, Filipe, Arêde, Cristina, Piedade, Susana, Morais-Almeida, Mário, Hindley, James, Yarham, Ross, Kuklinska-Pijanka, Anna, Gillick, David, Patient, Karine, Chapman, Martin D, Miranda, Ana, Matos, Eugénia, Sokolova, Anna, Rao, Huan, Baricevic-Jones, Ivona, Smith, Frances, Xue, Wentong, Magnusdottir, Helga, Vidarsdottir, Anna G, Lund, Sigrun, Jensen, Anders B, Ludviksson, Bjorn R, Simon, Reyna, Elfont, Robert, Bennett, Sean, Voyksner, Robert, de Lurdes Torre, Maria, Yürek, Songül, Faber, Margaretha A, Bastiaensen, Annick, Mangodt, Evelyne, van Gasse, Athina, Decuyper, Ine, Sabato, Vito, Hagendorens, Margo M, Bridts, Chris H, De Clerck, Luc S, Ebo, Didier, Schwarz, Susanne, Ziegert, Mandy, Albroscheit, Saskia, Schwager, Christian, Kull, Skadi, Behrends, Jochen, Röckendorf, Niels, Schocker, Frauke, Frey, Andreas, Homann, Arne, Becker, Wolf-Meinhard, Jappe, Uta, Zaabat, Nesrine, Osscini, Sylvia, Agabriel, Chantal, Sterling, Benoît, Carsin, Ania, Liabeuf, Valérie, Maćków, Monica, Zbróg, Alina, Bronkowska, Monica, Courtois, Justine, Gadisseur, Romy, Bertholet, Catherine, Lukas, Pierre, Cavalier, Etienne, Delahaut, Philippe, Quinting, Birgit, Gertmo, Margareta B, Hasseus, Ewa T, Barzylovych, Vladyslava, Oliveira, Júlio, Ensina, Luis F, Aranda, Carolina S, Dopazo, Leire, Lopez, Rebeca, Perez, Raquel, Santos-Diez, Laura, Bilbao, Agurtzane, Garcia, Juan M, Núñez, Ignacio G, Mármol, María Á A, Villarejo, María J B, Martos, José A B, Vergara, Marina S, García, José M I, Michalska, Agata, Sergiejko, Grzegorz, Zacniewski, Robert, Ghiordanescu, Ileana-Maria, Deaconu, Cristina, Popescu, Mihaela, Bumbacea, Roxana S, Ibranji, Alkerta, Nikolla, Elida, Loloci, Gjustina, Juel-Berg, Nanna, Larsen, Lau F, Poulsen, Lars K, Marcelino, João, Prata, Ricardo, Costa, Ana C, Duarte, Fátima, Neto, Marta, Santos, Jennifer, Pestana, Luís C, Sampaio, Daniel, Minale, Paola, Dignetti, Paola, Bignardi, Donatella, Nedelea, Irena, Popescu, Florin-Dan, Vieru, Mariana, Secureanu, Florin-Adrian, Ganea, Carmen S, Vieira, Miguel, Silva, José P M, Watts, Timothy, Watts, Sophia, Lomikovska, Marta, Peredelskaya, Marina, Nenasheva, Natalia, Filipovic, Ivana, Zivkovic, Zorica, Filipovic, Djordje, Higgs, Jennette, Warner, Amena, and Jones, Carla

Published
2017

29. 72nd Congress of the Italian Society of Pediatrics

Author

Braghero, Marco, primary, Staiano, Annamaria, additional, Biasin, Eleonora, additional, Matarazzo, Patrizia, additional, Einaudi, Silvia, additional, Manicone, Rosaria, additional, Felicetti, Francesco, additional, Brignardello, Enrico, additional, Fagioli, Franca, additional, Bignamini, Elisabetta, additional, Nave, Elena, additional, Callea, F., additional, Concato, C., additional, Fiscarelli, E., additional, Garrone, S., additional, de Gasperis, M.Rossi, additional, Calzi, Patrizia, additional, Marinelli, Grazia, additional, Besana, Roberto, additional, Caffarelli, Carlo, additional, Di Peri, Antonio, additional, Lapetina, Irene, additional, Cincinnati, Patrizia, additional, Da Riol, Rosalia Maria, additional, De Curtis, Mario, additional, Dito, Lucia, additional, Protano, Chiara, additional, Esposito, Susanna, additional, Ferrara, Dante, additional, Galiano, Rossella, additional, Novellino, Pasquale, additional, Kossoff, Eric Heath, additional, Krzysztofiak, Andrzej, additional, Bozzola, Elena, additional, Lancella, Laura, additional, Marchesi, Alessandra, additional, Villani, Alberto, additional, Lago, Paola, additional, Garetti, Elisabetta, additional, Pirelli, Anna, additional, Marchisio, Paola, additional, Santagati, Maria, additional, Stefani, Stefania, additional, Principi, Nicola, additional, d’Apolito, Valeria, additional, Memo, Luigi, additional, Selicorni, Angelo, additional, Miniello, Vito Leonardo, additional, Diaferio, Lucia, additional, Palmieri, Antonella, additional, Parola, Luciana, additional, Piro, Ettore, additional, Romano, Claudio, additional, Catena, Maria Ausilia, additional, Cardile, Sabrina, additional, Sacco, Oliviero, additional, Girosi, Donata, additional, Olcese, Roberta, additional, Tosca, Mariangela, additional, Rossi, Giovanni Arturo, additional, Salerno, Sergio, additional, Terranova, Maria Chiara, additional, Santamaria, Francesca, additional, Mancano, Giorgia, additional, Maitz, Silvia, additional, Stallings, Virginia A., additional, Berlolaso, Chiara, additional, McAnlis, Carolyn, additional, Schall, Joan I., additional, Striano, Pasquale, additional, Tanas, Rita, additional, De Iaco, Giulia, additional, Marsella, Maria, additional, Caggese, Guido, additional, Toma, Paolo, additional, Valentini, Piero, additional, Buonsenso, Danilo, additional, Pata, David, additional, Ceccarelli, Manuela, additional, Verduci, Elvira, additional, Brambilla, Marta, additional, Mariani, Benedetta, additional, Lassandro, Carlotta, additional, Dionigi, Alice Re, additional, Vizzuso, Sara, additional, Banderali, Giuseppe, additional, Panzarino, Gianvito, additional, Di Paolantonio, Claudia, additional, Verrotti, Alberto, additional, Cursi, Laura, additional, Grandin, Annalisa, additional, Virdis, Raffaele, additional, Carletti, Patrizia, additional, Weber, Giovanna, additional, Caiulo, Silvana, additional, and Vigone, Maria Cristina, additional

Published
2017
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32. 72nd Congress of the Italian Society of Pediatrics

Author

Braghero, Marco, Staiano, Annamaria, Biasin, Eleonora, Matarazzo, Patrizia, Einaudi, Silvia, Manicone, Rosaria, Felicetti, Francesco, Brignardello, Enrico, Fagioli, Franca, Bignamini, Elisabetta, Nave, Elena, Callea, F., Concato, C., Fiscarelli, E., Garrone, S., de Gasperis, M.Rossi, Calzi, Patrizia, Marinelli, Grazia, Besana, Roberto, Caffarelli, Carlo, Di Peri, Antonio, Lapetina, Irene, Cincinnati, Patrizia, Da Riol, Rosalia Maria, De Curtis, Mario, Dito, Lucia, Protano, Chiara, Esposito, Susanna, Ferrara, Dante, Galiano, Rossella, Novellino, Pasquale, Kossoff, Eric Heath, Krzysztofiak, Andrzej, Bozzola, Elena, Lancella, Laura, Marchesi, Alessandra, Villani, Alberto, Lago, Paola, Garetti, Elisabetta, Pirelli, Anna, Marchisio, Paola, Santagati, Maria, Stefani, Stefania, Principi, Nicola, d’Apolito, Valeria, Memo, Luigi, Selicorni, Angelo, Miniello, Vito Leonardo, Diaferio, Lucia, Palmieri, Antonella, Parola, Luciana, Piro, Ettore, Romano, Claudio, Catena, Maria Ausilia, Cardile, Sabrina, Sacco, Oliviero, Girosi, Donata, Olcese, Roberta, Tosca, Mariangela, Rossi, Giovanni Arturo, Salerno, Sergio, Terranova, Maria Chiara, Santamaria, Francesca, Mancano, Giorgia, Maitz, Silvia, Stallings, Virginia A., Berlolaso, Chiara, McAnlis, Carolyn, Schall, Joan I., Striano, Pasquale, Tanas, Rita, De Iaco, Giulia, Marsella, Maria, Caggese, Guido, Toma, Paolo, Valentini, Piero, Buonsenso, Danilo, Pata, David, Ceccarelli, Manuela, Verduci, Elvira, Brambilla, Marta, Mariani, Benedetta, Lassandro, Carlotta, Dionigi, Alice Re, Vizzuso, Sara, Banderali, Giuseppe, Panzarino, Gianvito, Di Paolantonio, Claudia, Verrotti, Alberto, Cursi, Laura, Grandin, Annalisa, Virdis, Raffaele, Carletti, Patrizia, Weber, Giovanna, Caiulo, Silvana, and Vigone, Maria Cristina

Subjects
Meeting Abstracts
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35. Role of FEF25-75 in managing children with newly-diagnosed asthma in clinical practice.

Author

Ciprandi G, Tosca MA, Schiavetti I, Olcese R, and Miraglia Del Giudice M

Subjects
Child, Female, Forced Expiratory Volume, Humans, Lung, Respiratory Function Tests, Spirometry, Asthma diagnosis
Abstract

Background Reversible bronchial obstruction characterizes asthma. Spirometry is the gold standard to assess airflow, and FEV1 is the most reliable parameter in this regard. However, many children with asthma have FEV1 within the normal range despite uncontrolled asthma and worsening. Therefore, FEF25-75 has been proposed as a valuable marker of early airflow impairment. This study aimed at investigating FEF25-75 in a cohort of children with newly diagnosed asthma. Methods 381 children (122 females, mean age 11.6 years) were consecutively visited and had a new asthma diagnosis. In addition, Spirometry, type-2 phenotyping, asthma control assessment, and ACT were performed. Results 72 (18.9%) asthmatic children had impaired FEF25-75, such as <65% of predicted. Low FEF25-75 was associated with lower FVC and FEV1/FVC values (OR 1.11 and 1.32, respectively). Children with normal FEV1 but impaired FEF25-75 had more frequently uncontrolled asthma (15.8% vs. 32.4%) than children with both parameters within the normal range. Conclusions FEF25-75 deserves adequate and careful consideration in children with asthma, and the presence of impaired FEF25-75 values suggests a more compelling approach.

Published
2022
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36. Allergen immunotherapy in children and adolescents with respiratory diseases.

Author

Tosca MA, Licari A, Olcese R, Castagnoli R, Marseglia A, Marseglia GL, Miraglia Del Giudice M, Martelli A, Calvani M, Caffarelli C, Duse M, Cravidi C, Cardinale F, and Ciprandi G

Subjects
Adolescent, Child, Desensitization, Immunologic, Humans, Quality of Life, Asthma therapy, Respiration Disorders, Rhinitis, Allergic therapy
Abstract

To date, the only disease-modifying treatment strategy for allergic rhinitis and asthma is allergen immunotherapy (AIT). There is evidence that AIT improves allergic rhinitis and asthma, such as reducing symptom severity and medication use and improving of quality of life, with a long-lasting effect after the end of the course. The recent clinical trials evidenced AIT effectiveness and safety in allergic asthma. Consequently, the current version of the GINA (Global Initiative for Asthma) guidelines recommend AIT as an add-on therapy for asthma. There is also evidence that AIT may exert preventive activity on the possible progression from allergic rhinitis to asthma in children and the onset of new sensitizations.

Published
2020
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37. Asthma in children and adolescents: the ControL'Asma project.

Author

Licari A, Ciprandi G, Marseglia GL, Silvestri M, Tosca MA, Anastasio E, Brambilla I, Caffarelli C, Castagnoli R, Chini L, Ciprandi R, De Vittori V, Duse M, Di Cicco ME, Indinnimeo L, Kantar A, Leone M, Marinelli G, Moschese V, Olcese R, Peroni DG, Pistorio A, Salmaso C, and Zicari AM

Subjects
Adolescent, Child, Comorbidity, Humans, Italy epidemiology, Male, Asthma epidemiology, Asthma therapy, Hypersensitivity, Rhinitis
Abstract

The control of asthma is the objective of asthma management. However, it is difficult to obtain in clinical practice. The Italian Society of Allergy and Clinical Immunology promoted the nationwide project "ControL'Asma" to investigate the real situation in a group of children and adolescents with asthma. The preliminary outcomes demonstrated that many asthmatic subjects do not achieve adequate asthma control. Moreover, asthma in Italian children and adolescents was usually more frequent in males, had an early onset and allergic phenotype with very frequent rhinitis comorbidity, uncontrolled and partly controlled asthma affected about the half of subjects. However, this project suggested that the assessment of asthma symptom perception by VAS could be a reliable tool in the asthma management.

Published
2020
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38. Lertal®, a multicomponent nutraceutical, could reduce the use of antihistamines in children with allergic rhinoconjunctivitis.

Author

Tosca MA, Olcese R, Marinelli G, Papale M, Zicari AM, Marseglia G, and Ciprandi G

Subjects
Child, Conjunctivitis, Allergic complications, Female, Humans, Male, Retrospective Studies, Rhinitis, Allergic complications, Conjunctivitis, Allergic therapy, Dietary Supplements, Histamine Antagonists administration & dosage, Rhinitis, Allergic therapy
Abstract

Antihistamines are the cornerstone treatment of allergic rhinitis (AR). To quantify the antihistaminic consume is particularly relevant in clinical practice, since a remarkable use is usually associated with severe symptoms. The aim of the study was to measure the use of antihistamines in two groups of children suffering from AR. The first group took a course of a nutraceutical (Lertal®) before the observation (active group, AG); a second one was considered as control (control group, CG). Both groups took antihistamines on demand. The children were visited at baseline and after 1 year. The number of days of antihistaminic use was the primary outcome. Children in AG had a significant reduced number of antihistamines use in comparison with CG (p=0.008). In conclusion, the current study showed that a course with a multicomponent nutraceutical could reduce the use of symptomatic antihistamines in children with allergic rhinoconjuncti- vitis.

Published
2020
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39. Small airways in children with allergic rhinoconjunctivitis: the potential role of a multicomponent nutraceutical.

Author

Leonardi S, Parisi G, Papale M, Zicari AM, Olcese R, Licari A, Marseglia G, and Ciprandi G

Subjects
Child, Conjunctivitis, Allergic complications, Female, Humans, Male, Maximal Expiratory Flow Rate, Organ Size, Respiratory System anatomy & histology, Retrospective Studies, Rhinitis, Allergic complications, Spirometry, Conjunctivitis, Allergic physiopathology, Conjunctivitis, Allergic therapy, Dietary Supplements, Rhinitis, Allergic physiopathology, Rhinitis, Allergic therapy
Abstract

Allergic rhinitis and asthma are closely linked. A progression from rhinitis to overt asthma is common. FEF25-75 is a spirometry parameter that could reflect small airways patency and could reliably predict early bronchial involvement in allergic rhinitis patients. MEF50 very strongly correlates with FEF25-75. The aim of this study was to evaluate possible spirometry change in two groups of children suffering from AR over time. The first group took a course of a nutraceutical (Lertal®) before the observation (active group, AG); a second one was considered as control (control group, CG). The children were visited at baseline, at the end of the nutraceutical course, and after 1 year. FEV1, FVC, and MEF50 were the primary outcomes. After one year, children in AG had significantly higher MEF50 than CG children (p=0.009). In conclusion, the present study showed that a course with a multicomponent nutraceutical could prevent the MEF50 decline in children with allergic rhinoconjunctivitis.

Published
2020
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40. Could Bet v 1 affect sensitization molecular pattern in children?

Author

Tosca MA, Silvestri M, Pistorio A, Olcese R, Del Barba P, and Ciprandi G

Subjects
Adolescent, Child, Child, Preschool, Female, Humans, Immunoglobulin E blood, Infant, Infant, Newborn, Male, Plant Proteins immunology, Retrospective Studies, Allergens immunology, Anaphylaxis immunology, Antigens, Plant immunology, Food Hypersensitivity immunology
Abstract

Background: Allergy is characterized by allergen-specific IgE production. Molecular-based allergy diagnostic allows to define the precise sensitization profile. Bet v 1 is the major allergen of the PR-10 family. It has been reported that pan-allergens could affect the sensitization panel in adults., Objective: This study aimed to evaluate the impact of Bet v 1 sensitization on clinical presentation in a sample of children with Bet v 1-sensitization; oral allergy syndrome (OAS) or anaphylaxis (ANA) were considered., Methods: Serum IgE molecular components were assessed by ISAC method. Sera and clinical data from 132 children, 91 males (68.94%) and 41 females (31.06%), mean age 9.08 years (3.45 years), were analyzed., Results: Bet v 1-sensitized children were frequently, but not exclusively, sensitized to other molecules belonging to PR-10 family. However, there was no significant difference concerning IgE levels between children with or without food allergy and between children with OAS and ANA, but hazelnut only for generic food allergy., Conclusions: The present study demonstrates that Bet v 1 sensitization may affect the sensitization pattern in children living in Genoa, a Mediterranean city located in a birch-free area, but it is unable to discriminate patients from a clinical point of view. So, ISAC test should be integrated with more precise IgE assay.

Published
2019
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