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1. A cost-effectiveness analysis of early detection and bundled treatment of postpartum hemorrhage alongside the E-MOTIVE trial

Author

Williams, Eleanor V., Goranitis, Ilias, Oppong, Raymond, Perry, Samuel J., Devall, Adam J., Martin, James T., Mammoliti, Kristie-Marie, Beeson, Leanne E., Sindhu, Kulandaipalayam N., Galadanci, Hadiza, Alwy Al‑beity, Fadhlun, Qureshi, Zahida, Hofmeyr, G. Justus, Moran, Neil, Fawcus, Sue, Mandondo, Sibongile, Middleton, Lee, Hemming, Karla, Oladapo, Olufemi T., Gallos, Ioannis D., Coomarasamy, Arri, and Roberts, Tracy E.

Published
2024
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2. Formative research to design an implementation strategy for a postpartum hemorrhage initial response treatment bundle (E-MOTIVE): study protocol

Author

Bohren, Meghan A, Lorencatto, Fabiana, Coomarasamy, Arri, Althabe, Fernando, Devall, Adam J, Evans, Cherrie, Oladapo, Olufemi T, Lissauer, David, Akter, Shahinoor, Forbes, Gillian, Thomas, Eleanor, Galadanci, Hadiza, Qureshi, Zahida, Fawcus, Sue, Hofmeyr, G Justus, Al-beity, Fadhlun Alwy, Kasturiratne, Anuradhani, Kumarendran, Balachandran, Mammoliti, Kristie-Marie, Vogel, Joshua P, Gallos, Ioannis, and Miller, Suellen

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Public Health, Health Sciences, Clinical Research, Prevention, Behavioral and Social Science, Good Health and Well Being, Female, Humans, Kenya, Motivation, Nigeria, Postpartum Hemorrhage, Pregnancy, South Africa, Sri Lanka, Tanzania, Maternal health, Postpartum hemorrhage, Obstetric hemorrhage, Care bundle, Formative research, Maternal mortality, Behavior change, Implementation, Intervention development, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Reproductive medicine, Public health
Abstract

BackgroundPostpartum hemorrhage (PPH) is the leading cause of maternal death worldwide. When PPH occurs, early identification of bleeding and prompt management using evidence-based guidelines, can avert most PPH-related severe morbidities and deaths. However, adherence to the World Health Organization recommended practices remains a critical challenge. A potential solution to inefficient and inconsistent implementation of evidence-based practices is the application of a 'clinical care bundle' for PPH management. A clinical care bundle is a set of discrete, evidence-based interventions, administered concurrently, or in rapid succession, to every eligible person, along with teamwork, communication, and cooperation. Once triggered, all bundle components must be delivered. The E-MOTIVE project aims to improve the detection and first response management of PPH through the implementation of the "E-MOTIVE" bundle, which consists of (1) Early PPH detection using a calibrated drape, (2) uterine Massage, (3) Oxytocic drugs, (4) Tranexamic acid, (5) Intra Venous fluids, and (6) genital tract Examination and escalation when necessary. The objective of this paper is to describe the protocol for the formative phase of the E-MOTIVE project, which aims to design an implementation strategy to support the uptake of this bundle into practice.MethodsWe will use behavior change and implementation science frameworks [e.g. capability, opportunity, motivation and behavior (COM-B) and theoretical domains framework (TDF)] to guide data collection and analysis, in Kenya, Nigeria, South Africa, Sri Lanka, and Tanzania. There are four methodological components: qualitative interviews; surveys; systematic reviews; and design workshops. We will triangulate findings across data sources, participant groups, and countries to explore factors influencing current PPH detection and management, and potentially influencing E-MOTIVE bundle implementation. We will use these findings to develop potential strategies to improve implementation, which will be discussed and agreed with key stakeholders from each country in intervention design workshops.DiscussionThis formative protocol outlines our strategy for the systematic development of the E-MOTIVE implementation strategy. This focus on implementation considers what it would take to support roll-out and implementation of the E-MOTIVE bundle. Our approach therefore aims to maximize internal validity in the trial alongside future scalability, and implementation of the E-MOTIVE bundle in routine practice, if proven to be effective.Trial registrationClinicalTrials.gov: NCT04341662.

Published
2021

4. Neglected medium-term and long-term consequences of labour and childbirth: a systematic analysis of the burden, recommended practices, and a way forward

Author

Vogel, Joshua P, Jung, Jenny, Lavin, Tina, Simpson, Grace, Kluwgant, Dvora, Abalos, Edgardo, Diaz, Virginia, Downe, Soo, Filippi, Veronique, Gallos, Ioannis, Galadanci, Hadiza, Katageri, Geetanjali, Homer, Caroline S E, Hofmeyr, G Justus, Liabsuetrakul, Tippawan, Morhason-Bello, Imran O, Osoti, Alfred, Souza, João Paulo, Thakar, Ranee, Thangaratinam, Shakila, and Oladapo, Olufemi T

Published
2024
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7. Global research priorities on COVID-19 for maternal, newborn, child and adolescent health

Author

ASM, Nawshad Uddin Ahmed, Maamri, Abdellatif, Falade, Adegoke G, Ayede, Adejumoke Idowu, Bhutta, Adnan, Gambhir, Ajay, Tagarro, Alfredo, Abdelmegeid, Ali, Ahmadi, Ali Reza, Barros, Aluísio JD, Mekasha, Amha, Srinivasaiyer, Anantha Kumar, da Silva, André Ricardo Araujo, Schultz, Andreas, Fatima, Batool, Dhar, Bishnupada, Magowan, Brian, Wills, Bridget, Raynes-Greenow, Camille, Homer, Caroline, Maclennan, Carolyn, Ward, Catherine, Garcia, Daniel Martinez, Ross, David, Murdoch, David, Wilson, Deborah Joy, Adejuyigbe, Ebun, Stasii, Ecaterina, Scudder, Elaine, Sacks, Emma, McCollum, Eric D, Althabe, Fernando, Russell, Fiona, Kumar, GS, Sommerfelt, Halvor, Graham, Hamish, Blencowe, Hannah, Tappis, Hannah, Saloojee, Haroon, Masaud, Hesham Abdussalam Ben, Tiwary, Hiresh, Asiodu, Ifeyinwa, Newton, James B, Bourdaire, Jessica, Adze, Joel Amwe, Martines, Jose, Lozano, Juan M, Walson, Judd, Rankin, Judith, Allegaert, Karel, Pellé, Karell G, Edmond, Karen, Rabiei, Katayoun, Rasmussen, Kathleen M, Yunis, Khalid, Ferguson, Laura, Greenslade, Leith, Kiapi, Lilian, Noguchi, Lisa, Bont, Louis, Day, Louise T, Mofenson, Lynne, Aboumayaleh, Maher, Aquzouz, Majda, Wahba, Mamdouh, Nagai, Mari, Knight, Marian, Melkumova, Marina, Jenyfa, Mariyam, Neuman, Mark I, Meremikwu, Martin, Kinney, Mary, Gravett, Michael, Hawkes, Michael T, Pacqué, Michel, Walsh, Michele, McGuire, Michelle K, AlShawafi, Nagiba AAbdulghani, Khuri-Bulos, Najwa, Thacker, Naveen, Rollins, Nigel, Kissoon, Niranjan, Starets, Olena, Picone, Olivier, Oladapo, Olufemi T, Erdeve, Omer, Smith, P Brian, Van de Perre, Philippe, Kumar, Praveen, Mangtani, Punam, Abbas, Qalab, Khatoon, Rabeya, Bahl, Rajiv, Lodha, Rakesh, Grais, Rebecca, Richards-Kortum, Rebecca, Rasaily, Reeta, Aryeetey, Richmond, Pattinson, Robert, and Petrucci, Roberta

Subjects
Public Health, Health Sciences, Pediatric, Prevention, Perinatal Period - Conditions Originating in Perinatal Period, Good Health and Well Being, Adolescent, Adolescent Health, COVID-19, Child, Child Health, Female, Global Health, Humans, Infant, Newborn, Pandemics, Research, SARS-CoV-2, COVID-19 Research Prioritization Group on MNCAH, Public Health and Health Services, Public health
Abstract

BackgroundThis research prioritization aimed to identify major research gaps in maternal, newborn, child and adolescent health (MNCAH) to help mitigate the direct and indirect effects of the COVID-19 pandemic.MethodsWe adapted the Child Health and Nutrition Research Initiative methodology. We defined scope, domains, themes and scoring criteria. We approached diverse global experts via email to submit their research ideas in MNCAH and MNCAH-related cross-cutting/health systems area. We curated the research ideas as research questions (RQs) and sent them to the consenting experts for scoring via the online link. For each RQ, the research priority score (RPS) was calculated as an average of individual criterion scores and ranked based on RPS in each area.ResultsWe identified top-ranked 10 RQs in each maternal, newborn, and child and adolescent health and 5 in the cross-cutting/health systems area. In maternal health, indirect effects on care, measures to improve care, health risks and outcomes, and preventing and managing SARS-CoV-2 infection/COVID-19 disease were priority RQs. In newborn health, clinical characterization and managing SARS-CoV-2 infection/COVID-19 disease, mode of transmission and interventions to prevent transmission were the focus. For child and adolescent health, top-ranked RQs were indirect effects on care, clinical status and outcomes, interventions to protect against SARS-CoV-2 infection/COVID-19 disease, and educational institute-related RQs. The cross-cutting RQs were the effects of the pandemic on availability, access, care-seeking and utilization of MNCAH services and potential solutions.ConclusionsWe call on partners, including governments, non-governmental organizations, research institutes, and donors, to address this urgent research agenda.

Published
2021

12. Effect of dexamethasone on newborn survival at different administration-to-birth intervals: A secondary analysis of the WHO ACTION (Antenatal CorticosTeroids for Improving Outcomes in Preterm Newborn)-I trial

Author

Oladapo, Olufemi T., Vogel, Joshua P., Piaggio, Gilda, Nguyen, My Huong, Althabe, Fernando, Bahl, Rajiv, Rao, Suman P.N., De Costa, Ayesha, Gupta, Shuchita, Baqui, Abdullah H., Shahidullah, Mohammod, Chowdhury, Saleha Begum, Goudar, Shivaprasad S., Dhaded, Sangappa M., Qureshi, Zahida P., Were, Fredrick, Kinuthia, John, Ayede, Adejumoke I., Adesina, Olubukola A., Kuti, Oluwafemi, Adejuyigbe, Ebunoluwa A., Ariff, Shabina, Soofi, Sajid B., Sheikh, Lumaan, Carvalho, Jose, Nilsson, Vania A., and Abreu, Luciana

Published
2022
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13. Antenatal dexamethasone for improving preterm newborn outcomes in low-resource countries: a cost-effectiveness analysis of the WHO ACTION-I trial

Author

Eddy, Katherine E, Vogel, Joshua P, Scott, Nick, Fetene, Dagnachew, Tidhar, Tom, Oladapo, Olufemi T, Piaggio, Gilda, Nguyen, My Huong, Althabe, Fernando, Bahl, Rajiv, Rao, Suman P N, De Costa, Ayesha, Gupta, Suchita, Baqui, Abdullah H., Shahidullah, Mohammod, Chowdhury, Saleha Begum, Ahmed, Salahuddin, Sultana, Saima, Jaben, Iffat Ara, Goudar, Shivaprasad S, Dhaded, Sangappa M, Pujar, Yeshita V, Vernekar, Sunil S, Welling, Saraswati, Katageri, Geetanjali M, Gudadinni, Muttappa R, Nanda, Saumya, Qureshi, Zahida, Baraka, Harriet Tunu, Osoti, Alfred, Gwako, George, Kinuthia, John, Ojo, Samuel, Adeponle, Adesina Olubukola, Idowu, Ayede Adejumoke, Adejuyigbe, Ebunoluwa Aderonke, Kuti, Oluwafemi, Kuti, Bankole Peter, Akinkunmi, Francis Bola, Kubeyinje, Weyinmi Emmanuel, Raji, Hadijat Olaide, Abiodun, Olusanya, Isah, Anthony Dennis, Ariff, Shabina, Soofi, Sajid Bashir, Sheikh, Lumaan, Aamir, Almas, and Raza, Farrukh

Published
2022
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15. Quality and outcomes of maternal and perinatal care for 76,563 pregnancies reported in a nationwide network of Nigerian referral-level hospitals

Author

Adeniran, Abiodun S, Gobir, Aishatu A, Ocheke, Amaka, Joy, Fatimah Baba, Rais, Ibrahim, Mairami, Amsa B, Ozegya, Mohammed S., Pam, Samuel, Ango, Sarah, Omoyine, Musa Abdulkarim, Patricia, Medupin, Ochejele, Silas, Agada, Egwu, Nwachukwu, Duum, Ahmed, Grace, Abdurrahman, Aisha, Ibrahim, Lawal M, Adamu, Aisha Nana, Na'uzo, Aliyu, Ashimi, Adewale, Idris, Umma, Adebola, Owodunni A, Akeredolu, Festus D, Adamu, Asma'u, Labaran, Aliyu, Oguntayo, Adekunle, Isa, Abdulkadir, Bature, Stephen, Ayuba, Andeyantso E, Abdullahi, Hauwa, Farouk, Zubaida L, Daneji, Sulaiman Muhammad, Isa, Umar, Adelaiye, Samuel, Kalle, Ismail M, Kadas, Saidu A, Bashir, Muhammad F, Moruppa, Joel, Bulus, Wasinda S, Yahaya, Usman R., Iliya, Jalo, Mairiga, Abdulkarim, Atterwahmie, Adamu, Hamza, Abdulhakeem, Wanonyi, Ishaya, John, Uniga A, Ayegbusi, Wole, Ayodeji, Adefemi, Imam, Zainab, Akinajo, Opeyemi, Fajolu, Iretiola, Akinsanya, Olufemi, Agelebe, Efeturi, Oluwasola, Timothy, Tongo, Olukemi O, Jagun, Olusoji, Opeyemi, Kuponiyi, Kuku, Olumide, Akindolire, Abimbola, Awonuga, David O, Dedeke, Iyabode Olabisi F., Akinkunmi, Francis, Olofinbiyi, Babatunde, Olatunde, Ogundare E, Aworinde, Olufemi, Adeyanju, Olusoji, Ibijoke, Campbell, Ande, Adedapo B, Abbasiatai, Aniekan, Nyong, Eno Etim, Ochigbo, Sunny, Omo‐Aghoja, Lawrence, Ekpebe, Patrick, Njoku, Anthonia, Eigbedion, Andrew, Orazulike, Ngozi, Okechukwu, Chioma, Igbaruma, Solomon, Ebe, Idemudia, Ede-Edokpolor, Osahon, Ibeawuchi, Amarabia, Ibrahim, Isa Ayuba, Adeyemi, Oyedeji O, Mgbafulu, Chukwuemeka C, Ukamaka, Onubogu C, Anayochukwu, Ugwu, Ekwochi, Uchenna, Chioma, Obinna-Njoku, Eleje, George, Ezenkwele, Eziamaka P, Obumneme-Anyim, Ijeoma, Ojiegbe, Nnabuike, Nwokeforo, Nathan U, Ezebialu, Ifeanyichukwu, Ejiofor, Obiora, Tukur, Jamilu, Lavin, Tina, Adanikin, Abiodun, Abdussalam, Muhammed, Bankole, Kuti, Ekott, Mabel Ikpim, Godwin, Akaba, Ibrahim, Halima A, Ikechukwu, Okonkwo, Kadas, Saidu Abubakar, Nwokeji-Onwe, Linda, Nzeribe, Emily, Ogunkunle, Taofik Oluwaseun, Oyeneyin, Lawal, Tunau, Karima A., Bello, Musa, Aminu, Is'haq, Ezekwe, Bosede, Aboyeji, Peter, Adesina, Olubukola A., Chama, Calvin, Etuk, Saturday, Galadanci, Hadiza, Ikechebelu, Joseph, and Oladapo, Olufemi T.

Published
2022
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17. Treatment of COVID-19 in pregnant women: A systematic review and meta-analysis

Author

Chatterjee, Shaunak, Gae, Andrea, Stallings, Elena, Yap, Magnus, Sheikh, Jameela, Lawson, Heidi, Coomar, Dyuti, Dixit, Anushka, Zhou, Dengyi, Balaji, Rishab, Littmoden, Megan, King, Yasmin, Debenham, Luke, Clavé Llavall, Anna, Ansari, Kehkashan, Sandhu, Gurimaan, Banjoko, Adeolu, Fraser, Helen, Rajah, Tanisha, Ramkumar, Anoushka, Khashaba, Alya, Attarde, Shruit, Walker, Kate, Thornton, Jim, van Wely, Madelon, van Leeuwen, Elizabeth, Kostova, Elena, Khalil, Asma, Tiberi, Simon, Broutet, Nathalie, Rahn Kim, Caron, Thorson, Anna, Oladapo, Olufemi T., Zamora, Javier, Mofenson, Lynne, Giesbers, Steven, Goh, Edwina, Kew, Tania, Allotey, John, Brizuela, Vanessa, Kara, Edna, Kunst, Heinke, Bonet, Mercedes, and Thangaratinam, Shakila

Published
2021
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18. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy : systematic review and meta-analysis

Author

PregCOV-19 Living Systematic Review Consortium, Allotey, John, Stallings, Elena, Bonet, Mercedes, Yap, Magnus, Chatterjee, Shaunak, Kew, Tania, Debenham, Luke, Llavall, Anna Clavé, Dixit, Anushka, Zhou, Dengyi, Balaj, Rishab, Lee, Siang Ing, Qiu, Xiu, Yuan, Mingyang, Coomar, Dyuti, Sheikh, Jameela, Lawson, Heidi, Ansari, Kehkashan, van Wely, Madelon, van Leeuwen, Elizabeth, Kostova, Elena, Kunst, Heinke, Khalil, Asma, Tiberi, Simon, Brizuela, Vanessa, Broutet, Nathalie, Kara, Edna, Kim, Caron Rahn, Thorson, Anna, Escuriet, Ramón, Oladapo, Olufemi T, Mofenson, Lynne, Zamora, Javier, and Thangaratinam, Shakila

Published
2020

21. Recurrent miscarriage: evidence to accelerate action

Author

Coomarasamy, Arri, Dhillon-Smith, Rima K, Papadopoulou, Argyro, Al-Memar, Maya, Brewin, Jane, Abrahams, Vikki M, Maheshwari, Abha, Christiansen, Ole B, Stephenson, Mary D, Goddijn, Mariëtte, Oladapo, Olufemi T, Wijeyaratne, Chandrika N, Bick, Debra, Shehata, Hassan, Small, Rachel, Bennett, Phillip R, Regan, Lesley, Rai, Raj, Bourne, Tom, Kaur, Rajinder, Pickering, Oonagh, Brosens, Jan J, Devall, Adam J, Gallos, Ioannis D, and Quenby, Siobhan

Published
2021
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22. Sporadic miscarriage: evidence to provide effective care

Author

Coomarasamy, Arri, Gallos, Ioannis D, Papadopoulou, Argyro, Dhillon-Smith, Rima K, Al-Memar, Maya, Brewin, Jane, Christiansen, Ole B, Stephenson, Mary D, Oladapo, Olufemi T, Wijeyaratne, Chandrika N, Small, Rachel, Bennett, Phillip R, Regan, Lesley, Goddijn, Mariëtte, Devall, Adam J, Bourne, Tom, Brosens, Jan J, and Quenby, Siobhan

Published
2021
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26. Strategies for optimising early detection and obstetric first response management of postpartum haemorrhage at caesarean birth: a modified Delphi-based international expert consensus

Author

Pingray, Verónica, primary, Williams, Caitlin R, additional, Al-beity, Fadhlun M Alwy, additional, Abalos, Edgardo, additional, Arulkumaran, Sabaratnam, additional, Blumenfeld, Alejandro, additional, Carvalho, Brendan, additional, Deneux-Tharaux, Catherine, additional, Downe, Soo, additional, Dumont, Alexandre, additional, Escobar, Maria Fernanda, additional, Evans, Cherrie, additional, Fawcus, Sue, additional, Galadanci, Hadiza S, additional, Hoang, Diem-Tuyet Thi, additional, Hofmeyr, G Justus, additional, Homer, Caroline, additional, Lewis, Ayodele G, additional, Liabsuetrakul, Tippawan, additional, Lumbiganon, Pisake, additional, Main, Elliott K, additional, Maua, Judith, additional, Muriithi, Francis G, additional, Nabhan, Ashraf Fawzy, additional, Nunes, Inês, additional, Ortega, Vanesa, additional, Phan, Thuan N Q, additional, Qureshi, Zahida P, additional, Sosa, Claudio, additional, Varallo, John, additional, Weeks, Andrew D, additional, Widmer, Mariana, additional, Oladapo, Olufemi T, additional, Gallos, Ioannis, additional, Coomarasamy, Arri, additional, Miller, Suellen, additional, and Althabe, Fernando, additional

Published
2024
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27. Burden and outcomes of postpartum haemorrhage in Nigerian referral‐level hospitals

Author

Adebayo, Tajudeen, primary, Adefemi, Ayodeji, additional, Adewumi, Idowu, additional, Akinajo, Opeyemi, additional, Akinkunmi, Bola, additional, Awonuga, David, additional, Aworinde, Olufemi, additional, Ayegbusi, Ekundayo, additional, Dedeke, Iyabode, additional, Fajolu, Iretiola, additional, Imam, Zainab, additional, Jagun, Olusoji, additional, Kuku, Olumide, additional, Ogundare, Ezra, additional, Oluwasola, Timothy, additional, Oyeneyin, Lawal, additional, Adebanjo‐Aina, Damilola, additional, Adenuga, Emmanuel, additional, Adeyanju, Alaruru, additional, Akinsanya, Olufemi, additional, Campbell, Ibijoke, additional, Kuti, Bankole, additional, Olofinbiyi, Babatunde, additional, Salau, Qasim, additional, Tongo, Olukemi, additional, Ezekwe, Bosede, additional, Lavin, Tina, additional, Oladapo, Olufemi T., additional, Tukur, Jamilu, additional, and Adesina, Olubukola, additional

Published
2024
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28. Maternal and perinatal health research during emerging and ongoing epidemic threats: a landscape analysis and expert consultation

Author

Bonet, Mercedes, primary, Babinska, Magdalena, additional, Buekens, Pierre, additional, Goudar, Shivaprasad S, additional, Kampmann, Beate, additional, Knight, Marian, additional, Meaney-Delman, Dana, additional, Lamprianou, Smaragda, additional, Rivas, Flor Muñoz, additional, Stergachis, Andy, additional, Toscano, Cristiana M, additional, Bhatia, Joycelyn, additional, Chamberlain, Sarah, additional, Chaudhry, Usman, additional, Mills, Jacqueline, additional, Serazin, Emily, additional, Short, Hannah, additional, Steene, Asher, additional, Wahlen, Michael, additional, and Oladapo, Olufemi T, additional

Published
2024
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29. Strategies for optimising early detection and obstetric first response management of postpartum haemorrhage at caesarean birth: a modified Delphi-based international expert consensus

Author

Pingray, Verónica, Williams, Caitlin R, Al-beity, Fadhlun M Alwy, Abalos, Edgardo, Arulkumaran, Sabaratnam, Blumenfeld, Alejandro, Carvalho, Brendan, Deneux-Tharaux, Catherine, Downe, Soo, Dumont, Alexandre, Escobar, Maria Fernanda, Evans, Cherrie, Fawcus, Sue, Galadanci, Hadiza S, Hoang, Diem-Tuyet Thi, Hofmeyr, G Justus, Homer, Caroline, Lewis, Ayodele G, Liabsuetrakul, Tippawan, Lumbiganon, Pisake, Main, Elliott K, Maua, Judith, Muriithi, Francis G, Nabhan, Ashraf Fawzy, Nunes, Inês, Ortega, Vanesa, Phan, Thuan N Q, Qureshi, Zahida P, Sosa, Claudio, Varallo, John, Weeks, Andrew D, Widmer, Mariana, Oladapo, Olufemi T, Gallos, Ioannis, Coomarasamy, Arri, Miller, Suellen, Althabe, Fernando, Pingray, Verónica, Williams, Caitlin R, Al-beity, Fadhlun M Alwy, Abalos, Edgardo, Arulkumaran, Sabaratnam, Blumenfeld, Alejandro, Carvalho, Brendan, Deneux-Tharaux, Catherine, Downe, Soo, Dumont, Alexandre, Escobar, Maria Fernanda, Evans, Cherrie, Fawcus, Sue, Galadanci, Hadiza S, Hoang, Diem-Tuyet Thi, Hofmeyr, G Justus, Homer, Caroline, Lewis, Ayodele G, Liabsuetrakul, Tippawan, Lumbiganon, Pisake, Main, Elliott K, Maua, Judith, Muriithi, Francis G, Nabhan, Ashraf Fawzy, Nunes, Inês, Ortega, Vanesa, Phan, Thuan N Q, Qureshi, Zahida P, Sosa, Claudio, Varallo, John, Weeks, Andrew D, Widmer, Mariana, Oladapo, Olufemi T, Gallos, Ioannis, Coomarasamy, Arri, Miller, Suellen, and Althabe, Fernando

Abstract

Objective There are no globally agreed on strategies on early detection and first response management of postpartum haemorrhage (PPH) during and after caesarean birth. Our study aimed to develop an international expert’s consensus on evidence-based approaches for early detection and obstetric first response management of PPH intraoperatively and postoperatively in caesarean birth. Design Systematic review and three-stage modified Delphi expert consensus. Setting International. Population Panel of 22 global experts in PPH with diverse backgrounds, and gender, professional and geographic balance. Outcome measures Agreement or disagreement on strategies for early detection and first response management of PPH at caesarean birth. Results Experts agreed that the same PPH definition should apply to both vaginal and caesarean birth. For the intraoperative phase, the experts agreed that early detection should be accomplished via quantitative blood loss measurement, complemented by monitoring the woman’s haemodynamic status; and that first response should be triggered once the woman loses at least 500 mL of blood with continued bleeding or when she exhibits clinical signs of haemodynamic instability, whichever occurs first. For the first response, experts agreed on immediate administration of uterotonics and tranexamic acid, examination to determine aetiology and rapid initiation of cause-specific responses. In the postoperative phase, the experts agreed that caesarean birth-related PPH should be detected primarily via frequently monitoring the woman’s haemodynamic status and clinical signs and symptoms of internal bleeding, supplemented by cumulative blood loss assessment performed quantitatively or by visual estimation. Postoperative first response was determined to require an individualised approach. Conclusion These agreed on proposed approaches could help improve the detection of PPH in the intraoperative and postoperative phases of caesarean birth and the first respons

Published
2024
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33. Correction: Factors influencing appropriate use of interventions for management of women experiencing preterm birth: A mixed-methods systematic review and narrative synthesis

Author

Zahroh, Rana Islamiah, Hazfiarini, Alya, Eddy, Katherine E., Vogel, Joshua P., Tunçalp, Ó¦zge, Minckas, Nicole, Althabe, Fernando, Oladapo, Olufemi T., and Bohren, Meghan A.

Subjects
Biological sciences
Abstract

Author(s): Rana Islamiah Zahroh, Alya Hazfiarini, Katherine E. Eddy, Joshua P. Vogel, Ó¦zge Tunçalp, Nicole Minckas, Fernando Althabe, Olufemi T. Oladapo, Meghan A. Bohren The copyright information is incorrect. The [...]

Published
2022
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35. Unveiling the strong positive relationship: Maternal characteristics and neonatal outcomes in the Better Outcomes in Labour Difficulty (BOLD) study – a secondary analysis validating neonatal near miss classification

Author

Nogueira-Pileggi, Vicky, primary, Oladapo, Olufemi T, additional, Souza, João Paulo, additional, Cavenague de Souza, Hayala Cristina, additional, Pileggi-Castro, Cynthia, additional, Oyeneyin, Lawal O, additional, Oliveira-Ciabati, Livia, additional, Barbosa, Francisco, additional, and Camelo, José Simon, additional

Published
2024
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36. Establishment of Maternal and Perinatal Database for Quality, Equity and Dignity programme: Processes, challenges, lessons and prospects.

Author

Adanikin, Abiodun, Tukur, Jamilu, Lavin, Tina, Ezekwe, Bosede, Aminu, Is'haq, Aboyeji, Peter, Adesina, Olubukola, Chama, Calvin, Etuk, Saturday, Galadanci, Hadiza, Ikechebelu, Joseph, and Oladapo, Olufemi T.

Subjects
HEALTH facilities, PREMATURE rupture of fetal membranes, ABORTION, DELIVERY (Obstetrics), HUMAN reproduction, HEALTH information systems, INDUCED labor (Obstetrics)
Abstract

The article discusses the establishment of the Maternal and Perinatal Database for Quality, Equity, and Dignity (MPD-4-QED) program in Nigeria, which aims to monitor the quality of maternal and newborn care in referral-level hospitals. The program collects data through an electronic platform and involves medical record officers and hospital coordinators. The article highlights implementation challenges, lessons learned, and future prospects. The document provides lists of hospitals, indicators, and definitions related to healthcare quality, as well as variables and descriptions for studying obstetrics and clinical conditions during pregnancy and labor. It also includes medical terms and definitions, and data elements for neonatal care, gynecological admissions, maternal death audits, and perinatal death audits. These resources are valuable for researchers studying healthcare in Nigeria and maternal and baby health. [Extracted from the article]

Published
2024
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37. Outcomes and quality of care for women and their babies after caesarean section in Nigeria.

Author

Adeniran, Abiodun S., Nwachukwu, Duum C., Ocheke, Amaka N., Mohammed, Salisu O, Musa, Abdulkarim O., Ochejele, Silas, Ibraheem, Rais S., Pam, Samuel, Mairami, Amsa B., Gobir, Aishatu A., Olateju, Eyinade K., Baba, Fatimah J., Medupin, Patricia F., Ahmed, Grace, Ango, Sarah, Akaba, Godwin, Ogunkunle, Taofik O., Agada, Egwu, Gibbons, Luz, and Oladapo, Olufemi T.

Subjects
MATERNAL mortality, CESAREAN section, WOMEN'S mortality, PERINATAL death, SOCIODEMOGRAPHIC factors
Abstract

Objective: To describe the outcomes and quality of care for women and their babies after caesarean section (CS) in Nigerian referral‐level hospitals. Design: Secondary analysis of a nationwide cross‐sectional study. Setting: Fifty‐four referral‐level hospitals. Population: All women giving birth in the participating facilities between 1 September 2019 and 31 August 2020. Methods: Data for the women were extracted, including sociodemographic data, clinical information, mode of birth, and maternal and perinatal outcomes. A conceptual hierarchical framework was employed to explore the sociodemographic and clinical factors associated with maternal and perinatal death in women who had an emergency CS. Main Outcome Measures: Overall CS rate, outcomes for women who had CS, and factors associated with maternal and perinatal mortality. Results: The overall CS rate was 33.3% (22 838/68 640). The majority of CS deliveries were emergency cases (62.8%) and 8.1% of CS deliveries had complications after delivery, which were more common after an emergency CS. There were 179 (0.8%) maternal deaths in women who had a CS and 29.6% resulted from complications of hypertensive disorders of pregnancy. The overall maternal mortality rate in women who delivered by CS was 778 per 100 000 live births, whereas the perinatal mortality at birth was 51 per 1000 live births. Factors associated with maternal mortality in women who had an emergency CS were being <20 or >35 years of age, having a lower level of education and being referred from another facility or informal setting. Conclusions: One‐third of births were delivered via CS (mostly emergency), with almost one in ten women experiencing a complication after a CS. To improve outcomes, hospitals should invest in care and remove obstacles to accessible quality CS services. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Neglected medium-term and long-term consequences of labour and childbirth: a systematic analysis of the burden, recommended practices, and a way forward

Author

Vogel, Joshua P, primary, Jung, Jenny, additional, Lavin, Tina, additional, Simpson, Grace, additional, Kluwgant, Dvora, additional, Abalos, Edgardo, additional, Diaz, Virginia, additional, Downe, Soo, additional, Filippi, Veronique, additional, Gallos, Ioannis, additional, Galadanci, Hadiza, additional, Katageri, Geetanjali, additional, Homer, Caroline S E, additional, Hofmeyr, G Justus, additional, Liabsuetrakul, Tippawan, additional, Morhason-Bello, Imran O, additional, Osoti, Alfred, additional, Souza, João Paulo, additional, Thakar, Ranee, additional, Thangaratinam, Shakila, additional, and Oladapo, Olufemi T, additional

Published
2023
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39. Vulnerabilities and reparative strategies during pregnancy, childbirth, and the postpartum period: moving from rhetoric to action

Author

Sheikh, Jameela, primary, Allotey, John, additional, Kew, Tania, additional, Khalil, Halimah, additional, Galadanci, Hadiza, additional, Hofmeyr, G Justus, additional, Abalos, Edgardo, additional, Vogel, Joshua P., additional, Lavin, Tina, additional, Souza, João Paulo, additional, Kaur, Inderjeet, additional, Ram, Uma, additional, Betran, Ana Pilar, additional, Bohren, Meghan A., additional, Oladapo, Olufemi T., additional, and Thangaratinam, Shakila, additional

Published
2023
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41. Towards a better tomorrow: addressing intersectional gender power relations to eradicate inequities in maternal health

Author

Bohren, Meghan A., primary, Iyer, Aditi, additional, Barros, Aluisio J.D., additional, Williams, Caitlin R., additional, Hazfiarini, Alya, additional, Arroyave, Luisa, additional, Filippi, Veronique, additional, Chamberlain, Catherine, additional, Kabakian-Khasholian, Tamar, additional, Mayra, Kaveri, additional, Gill, Roopan, additional, Vogel, Joshua P., additional, Chou, Doris, additional, George, Asha S., additional, and Oladapo, Olufemi T., additional

Published
2023
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42. Factors influencing appropriate use of interventions for management of women experiencing preterm birth: A mixed-methods systematic review and narrative synthesis

Author

Zahroh, Rana Islamiah, Hazfiarini, Alya, Eddy, Katherine E., Vogel, Joshua P., Tunçalp, Ó¦zge, Minckas, Nicole, Althabe, Fernando, Oladapo, Olufemi T., and Bohren, Meghan A.

Subjects
Maternal health services -- Management -- Usage, Premature birth -- Management, Company business management, Biological sciences
Abstract

Background Preterm birth-related complications are the leading cause of death in newborns and children under 5. Health outcomes of preterm newborns can be improved with appropriate use of antenatal corticosteroids (ACSs) to promote fetal lung maturity, tocolytics to delay birth, magnesium sulphate for fetal neuroprotection, and antibiotics for preterm prelabour rupture of membranes. However, there are wide disparities in the rate and consistency in the use of these interventions across settings, which may underlie the differential health outcomes among preterm newborns. We aimed to assess factors (barriers and facilitators) affecting the appropriate use of ACS, tocolytics, magnesium sulphate, and antibiotics to improve preterm birth management. Methods and findings We conducted a mixed-methods systematic review including primary qualitative, quantitative, and mixed-methods studies. We searched MEDLINE, EMBASE, CINAHL, Global Health, and grey literature from inception to 16 May 2022. Eligible studies explored perspectives of women, partners, or community members who experienced preterm birth or were at risk of preterm birth and/or received any of the 4 interventions, health workers providing maternity and newborn care, and other stakeholders involved in maternal care (e.g., facility managers, policymakers). We used an iterative narrative synthesis approach to analysis, assessed methodological limitations using the Mixed Methods Appraisal Tool, and assessed confidence in each qualitative review finding using the GRADE-CERQual approach. Behaviour change models (Theoretical Domains Framework; Capability, Opportunity, and Motivation (COM-B)) were used to map barriers and facilitators affecting appropriate use of these interventions. We included 46 studies from 32 countries, describing factors affecting use of ACS (32/46 studies), tocolytics (13/46 studies), magnesium sulphate (9/46 studies), and antibiotics (5/46 studies). We identified a range of barriers influencing appropriate use of the 4 interventions globally, which include the following: inaccurate gestational age assessment, inconsistent guidelines, varied knowledge, perceived risks and benefits, perceived uncertainties and constraints in administration, confusion around prescribing and administering authority, and inadequate stock, human resources, and labour and newborn care. Women reported hesitancy in accepting interventions, as they typically learned about them during emergencies. Most included studies were from high-income countries (37/46 studies), which may affect the transferability of these findings to low- or middle-income settings. Conclusions In this study, we identified critical factors affecting implementation of 4 interventions to improve preterm birth management globally. Policymakers and implementers can consider these barriers and facilitators when formulating policies and planning implementation or scale-up of these interventions. Study findings can inform clinical preterm birth guidelines and implementation to ensure that barriers are addressed, and enablers are reinforced to ensure these interventions are widely available and appropriately used globally., Author(s): Rana Islamiah Zahroh 1, Alya Hazfiarini 1, Katherine E. Eddy 2, Joshua P. Vogel 2,Ó¦zge Tunçalp 3, Nicole Minckas 4, Fernando Althabe 3, Olufemi T. Oladapo 3, Meghan A. [...]

Published
2022
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45. Perceptions and experiences of the prevention, detection, and management of postpartum haemorrhage: a qualitative evidence synthesis

Author

Akter, Shahinoor, additional, Forbes, Gillian, additional, Vazquez Corona, Martha, additional, Miller, Suellen, additional, Althabe, Fernando, additional, Coomarasamy, Arri, additional, Gallos, Ioannis D, additional, Oladapo, Olufemi T, additional, Vogel, Joshua P, additional, Lorencatto, Fabiana, additional, and Bohren, Meghan A, additional

Published
2023
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46. Maternal and perinatal health research during emerging and ongoing epidemic threats: a landscape analysis and expert consultation

Author

Bonet, Mercedes, primary, Babinska, Magdalena, additional, Buekens, Pierre, additional, Goudar, Shivaprasad, additional, Kampmann, Beate, additional, Knight, Marian, additional, Meaney-Delman, Dana, additional, Lamprianou, Smaragda, additional, Munoz, Flor M, additional, Stergachis, Andy, additional, Toscano, Cristiana, additional, Bhatia, Joycelyn, additional, Chamberlain, Sarah, additional, Chaudhry, Usman, additional, Mills, Jacqueline, additional, Serazin, Emily, additional, Short, Hannah, additional, Steene, Asher, additional, Wahlen, Michael, additional, and Oladapo, Olufemi T, additional

Published
2023
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47. The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) Trial: study protocol for a multi-country, multi-centre, double-blind, three-arm, placebo-controlled, individually randomized trial of antenatal corticosteroids for women at high probability of late preterm birth in hospitals in low- and middle-income countries

Author

Adegboyega, Temitope Adesiji, primary, Adejuyigbe, Ebunoluwa Aderonke, additional, Adesina, Olubukola Adeponle, additional, Adeyemi, Babalola, additional, Ahmed, Salahuddin, additional, Akinkunmi, Francis, additional, Aluvaala, Jalemba, additional, Anyabolu, Henry, additional, Ariff, Shabina, additional, Arya, Sugandha, additional, Awowole, Ibrahim, additional, AYEDE, Adejumoke Idowu, additional, Babar, Neelofur, additional, Bachani, Sumitra, additional, Bahl, Rajiv, additional, Baqui, Abdullah H., additional, Chellani, Harish, additional, Chowdhury, Saleha Begum, additional, Coppola, Lynn M, additional, Cousens, Simon, additional, Debata, Pradeep K, additional, De Costa, Ayesha, additional, Dhaded, Sangappa M, additional, Donimath, Kasturi V, additional, Falade, Adegoke Gbadegesin, additional, Goudar, Shivaprasad S, additional, Gupta, Shuchita, additional, Gwako, George N, additional, Irinyenikan, Theresa Azonima, additional, Isah, Dennis Anthony, additional, Jabeen, Nigar, additional, Javed, Arshia, additional, Joseph, Naima T, additional, Khanam, Rasheda, additional, Kinuthia, John, additional, Kuti, Oluwafemi, additional, Lavin, Tina, additional, Laving, Ahmed R, additional, Maranna, Sandhya, additional, Minckas, Nicole, additional, Mittal, Pratima, additional, Mohan, Diwakar, additional, Nausheen, Sidrah, additional, Nguyen, My Huong, additional, Oladapo, Olufemi T, additional, Olutekunbi, Olanike Abosede, additional, Oluwafemi, Rosena Olubanke, additional, Osoti, Alfred, additional, Pujar, Yeshita V, additional, Qureshi, Zahida P, additional, Rao, Suman PN, additional, Sarrassat, Sophie, additional, Shahed, M A, additional, Shahidullah, Mohammod, additional, Sheikh, Lumaan, additional, Somannavar, Manjunath S, additional, Soofi, Sajid, additional, Suri, Jyotsna, additional, Vernekar, Sunil S, additional, Vogel, Joshua P, additional, Wadhwa, Nitya, additional, Wari, Praksah K, additional, Were, Fred, additional, and Wylie, Blair J, additional

Published
2023
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50. Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage

Author

Gallos, Ioannis, primary, Devall, Adam, additional, Martin, James, additional, Middleton, Lee, additional, Beeson, Leanne, additional, Galadanci, Hadiza, additional, Alwy Al-beity, Fadhlun, additional, Qureshi, Zahida, additional, Hofmeyr, G. Justus, additional, Moran, Neil, additional, Fawcus, Sue, additional, Sheikh, Lumaan, additional, Gwako, George, additional, Osoti, Alfred, additional, Aswat, Ashraf, additional, Mammoliti, Kristie-Marie, additional, Sindhu, Kulandaipalayam N., additional, Podesek, Marcelina, additional, Horne, Isobelle, additional, Timms, Rebecca, additional, Yunas, Idnan, additional, Okore, Jenipher, additional, Singata-Madliki, Mandisa, additional, Arends, Edna, additional, Wakili, Aminu A., additional, Mwampashi, Ard, additional, Nausheen, Sidrah, additional, Muhammad, Shah, additional, Latthe, Pallavi, additional, Evans, Cherrie, additional, Akter, Shahinoor, additional, Forbes, Gillian, additional, Lissauer, David, additional, Meher, Shireen, additional, Weeks, Andrew, additional, Shennan, Andrew, additional, Ammerdorffer, Anne, additional, Williams, Eleanor, additional, Roberts, Tracy, additional, Widmer, Mariana, additional, Oladapo, Olufemi T., additional, Lorencatto, Fabiana, additional, Bohren, Meghan A., additional, Miller, Suellen, additional, Althabe, Fernando, additional, Gülmezoglu, Metin, additional, Smith, Jeffrey M., additional, Hemming, Karla, additional, and Coomarasamy, Arri, additional

Published
2023
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