13 results on '"Olívia Gonçalves Leão Coelho"'
Search Results
2. The influence of planting and harvesting times on the total phenolic content and antioxidant activity of Talinum triangulare (Jacq.) Willd
- Author
-
Beatriz Gonçalves Brasileiro, João Paulo Viana Leite, Vicente Wagner Dias Casali, Virgínia Ramos Pizziolo, and Olívia Gonçalves Leão Coelho
- Subjects
portulacaceae ,waterleaf ,DPPH ,polyphenol ,Agriculture (General) ,S1-972 - Abstract
The purpose of this study was to evaluate the influence of planting and harvesting times on the polyphenol content and antioxidant capacity of Talinum triangulare cultivated during two different seasons (winter or summer) and harvested 30 or 60 days after seedling establishment. Polyphenol content was quantified with the Folin-Ciocalteu method, and antioxidant activity was quantified with free-radical DPPH (1,1-diphenyl-2-picrilhidrazina). The highest levels of polyphenols were obtained from winter planting and from harvesting at 30 days. Antioxidant activity differed significantly in response to variation in planting and harvesting times, reaching 56.97% in extracts of plants produced in the winter and harvested at 30 days after planting. The times of planting and harvesting markedly influenced the content of polyphenols, and thus the antioxidant activity, of T. triangulare.
- Published
- 2015
- Full Text
- View/download PDF
3. Can grape polyphenols affect glycation markers? A systematic review
- Author
-
Olívia Gonçalves Leão Coelho, Priscila Vaz de Melo Ribeiro, and Rita de Cássia Gonçalves Alfenas
- Subjects
Antioxidant ,food.ingredient ,business.industry ,medicine.medical_treatment ,fungi ,Methylglyoxal ,food and beverages ,General Medicine ,Pharmacology ,Resveratrol ,Industrial and Manufacturing Engineering ,RAGE (receptor) ,chemistry.chemical_compound ,food ,Proanthocyanidin ,chemistry ,Polyphenol ,Glycation ,Grape seed extract ,medicine ,business ,Food Science - Abstract
Advanced glycation end-products (AGEs) favor inflammation and oxidative stress, playing a role in chronic diseases pathogenesis. Grape polyphenols exert antiglycative and antioxidant effects which may contribute to prevent chronic diseases. However, clinical evidence of grape polyphenols on chronic disease prevention and treatment by glycation markers modulation are limited. Therefore, we aimed to critically analyze studies about that topic to investigate the antiglycative power of dietary grape polyphenol, and to explore the molecular mechanism involved. This systematic review was conducted and reported according to PRISMA guidelines. The following search terms were used: "grape", "extract", "grape seed extract", "grape skin extract", "polyphenol extract", "grape polyphenol(s)", "grape juice", "resveratrol", "quercetin", "catechin", "epicatechin", "procyanidin(s)", and "anthocyanin(s)". Seven studies were included. Glycated hemoglobin was not affected. The interventions duration may not have been enough to detect changes. Grape polyphenols reduced fructosamine and methylglyoxal (MGO) concentrations, and increased endogenous secretory RAGE (esRAGE) gene expression but did not affect the serum concentration. Resveratrol antiglycative effects are mainly due its ability to trap MGO and downregulate RAGE. In conclusion, grape polyphenols may have a positive impact on early glycation products, AGEs and esRAGE. Future studies are needed to explore how they modulate AGEs and receptors in chronic diseases.
- Published
- 2021
4. Effects of Concord grape juice flavor intensity and phenolic compound content on glycemia, appetite and cognitive function in adults with excess body weight: a randomized double-blind crossover trial
- Author
-
Hawi Debelo, JoLynne D. Wightman, Olívia Gonçalves Leão Coelho, Mario G. Ferruzzi, Rita de Cássia Gonçalves Alfenas, and Richard D. Mattes
- Subjects
Adult ,Blood Glucose ,Male ,media_common.quotation_subject ,Appetite ,Thirst ,Cognition ,Double-Blind Method ,Phenols ,medicine ,Humans ,Vitis ,Food science ,wine.grape_variety ,Flavor ,Glycemic ,media_common ,Meal ,Cross-Over Studies ,business.industry ,food and beverages ,General Medicine ,Concord grape ,Crossover study ,Fruit and Vegetable Juices ,Postprandial ,wine ,Female ,medicine.symptom ,business ,Food Science - Abstract
Background & aims: Concord grape (Vitis lambrusca) juice (CGJ) contains a unique combination of polyphenolic compounds with diverse effects on human health. It also has an intense sensory profile that may modify food choice. Daily consumption of CGJ over 8 weeks reduced fasting blood glucose. However, the impact on 24h-postprandial glucose response from CGJ is still not clear. The purpose of this study was to assess the effect of CGJ flavor intensity and phenolic content on 24 h postprandial glucose concentrations, appetitive sensations, and cognitive function in adults with excess body weight when consumed alone or with a meal. Methods: In a randomized, double-blind, crossover design study, participants consumed three types of beverages: 100% CGJ, a polyphenol-free grape flavored drink with the same flavor essence (LP) or a polyphenol-free grape flavored drink with reduced flavor essence (LPF) either without (trial I) or with (trial II) a meal. 24 h glucose was measured through continuous glucose monitoring. Phenolic metabolite excretion was assessed in 24 h urine samples. Appetite (hunger, thirst, fullness, desire to eat, and prospective consumption) and cognitive function (alertness, energetic, strength, calmness, and relaxation) were assessed hourly through visual analog scales. Results: Thirty-four adults completed trial I and 34 adults completed trial II. When consumed with a meal, beverages with customary flavor essence (CGJ and LP) reduced hunger, desire to eat, and prospective consumption and consumption of the polyphenol-free reduced flavor essence beverage was associated with higher 24 h glucose tAUC. No consistent effects were observed for cognitive outcomes. When consumed alone, CGJ was related to lower glycemic responses by those excreting a higher concentration of the phenolic metabolite iso/ferulic-3′-O-glucuronide, but in beverages without CG phenolics and reduced flavor essence, glycemia was higher among those excreting higher concentrations of caffeic acid-O-sulfate. Conclusions: Both natural phenolics and flavor essence of CGJ may help to moderate appetite and glycemia. Clinical Trials registered at http://www.clinicaltrials.gov: NCT03409484 (trial I) and NCT03409497 (trial II).
- Published
- 2021
5. Reply to letter to the editor: 'Advanced glycation end-products and their receptors: Exercise effects'
- Author
-
Laís Emilia da Silva, Priscila Vaz de Melo Ribeiro, Rita de Cássia Gonçalves Alfenas, Olívia Gonçalves Leão Coelho, and Juliana F. Tavares
- Subjects
Glycation End Products, Advanced ,Letter to the editor ,business.industry ,Endocrinology, Diabetes and Metabolism ,Public Health, Environmental and Occupational Health ,Physical activity ,Pharmacology ,chemistry.chemical_compound ,chemistry ,Glycation ,Weight Loss ,Advanced glycation end-product ,Medicine ,Humans ,ddc:610 ,Receptor ,business ,Exercise ,Biomarkers - Published
- 2020
6. Can advanced glycation end‐products and their receptors be affected by weight loss? A systematic review
- Author
-
Laís Emilia da Silva, Priscila Vaz de Melo Ribeiro, Rita de Cássia Gonçalves Alfenas, Olívia Gonçalves Leão Coelho, and Juliana F. Tavares
- Subjects
Glycation End Products, Advanced ,Endocrinology, Diabetes and Metabolism ,Receptor for Advanced Glycation End Products ,Physiology ,030209 endocrinology & metabolism ,Overweight ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Weight loss ,Glycation ,Weight Loss ,Weight management ,medicine ,Humans ,030212 general & internal medicine ,Receptor ,business.industry ,Public Health, Environmental and Occupational Health ,medicine.disease ,Obesity ,chemistry ,Biomarker (medicine) ,Advanced glycation end-product ,medicine.symptom ,business - Abstract
Advanced glycation end products (AGEs) have been implicated in the pathogenesis of most chronic diseases. Therefore, identification of treatments that can attenuate the effects of these compounds and prevent cardiometabolic complications is of extreme public health interest. Recently, body weight management interventions showed positive results on reducing serum AGE concentrations. Moreover, the soluble receptor for advanced glycation end products (sRAGE) is considered to be a novel biomarker to identify patients with obesity most likely to benefit from weight management interventions. This systematic review aimed to critically analyze papers evaluating the effects of weight loss on serum AGEs and its receptors in adults with excess body weight. MEDLINE, Cochrane, Scopus, and Lilacs databases were searched. Three studies evaluating the response of AGEs to energy-restricted diets and six assessing sRAGE as the primary outcome were included. Energy-restricted diets and bariatric surgery reduced serum AGE concentrations, but effects on endogenous secretory RAGE (esRAGE) and sRAGE concentrations are conflicting. These results may be associated with mechanisms related to changes in dietary intake and limiting endogenous AGE formation. Therefore, the role of energy-restricted diets and bariatric surgery on lowering serum AGE concentrations, as well as its effects on AGEs receptors, deserves further investigation.
- Published
- 2020
7. Dietary fat and gut microbiota: mechanisms involved in obesity control
- Author
-
Olívia Gonçalves Leão Coelho, Flávia Galvão Cândido, and Rita de Cássia Gonçalves Alfenas
- Subjects
medicine.medical_specialty ,030309 nutrition & dietetics ,Conjugated linoleic acid ,Biology ,Gut flora ,digestive system ,Industrial and Manufacturing Engineering ,03 medical and health sciences ,chemistry.chemical_compound ,0404 agricultural biotechnology ,Internal medicine ,medicine ,Humans ,Obesity ,Dietary fat ,Metabolic health ,chemistry.chemical_classification ,0303 health sciences ,04 agricultural and veterinary sciences ,General Medicine ,medicine.disease ,biology.organism_classification ,Dietary Fats ,040401 food science ,Gastrointestinal Microbiome ,Endocrinology ,chemistry ,Normal weight ,Dysbiosis ,Food Science ,Polyunsaturated fatty acid - Abstract
Obesity is a serious global health problem that is directly related to various morbidities manifestation. Intestinal dysbiosis has been implicated on obesity pathogenesis. Diet composition can alter gut microbiota, regardless of energy intake. Dietary fatty acids quality may affect gut microbiota composition, which in turn may affect host metabolic health. The mechanisms by which the different type of FFA modulate gut microbiota is yet poor elucidate and there is a lack of studies regard to this. Fatty acids may act in cell membrane, interfere with energy production, inhibit enzymatic activities, impair nutrient absorption and generate toxic compounds to cells, leading to growth inhibition or even bacterial death. The beneficial effect of the consumption of n-3 polyunsaturated fatty acids (PUFA) and conjugated linoleic acid (CLA) on microbiota, unlike n-6 PUFA and saturated fatty acids has been suggested. n-3 PUFA consumption promotes desirable changes on obese intestinal microbiota making it similar to that of normal weight individuals. More studies are needed to better understand the effect of CLA on microbiota and host health. Long term human controlled clinical trials must be conducted to allow us to understand the complex interaction between dietary fat, intestinal microbiota and obesity.
- Published
- 2018
8. Cranberry antioxidant power on oxidative stress, inflammation and mitochondrial damage
- Author
-
Josefina Bressan, Ana Paula Silva Caldas, and Olívia Gonçalves Leão Coelho
- Subjects
0301 basic medicine ,Antioxidant ,medicine.medical_treatment ,Inflammation ,Free radicals ,lcsh:TX341-641 ,Pharmacology ,medicine.disease_cause ,Antioxidants ,03 medical and health sciences ,chemistry.chemical_compound ,food ,medicine ,Vaccinium macrocarpon ,chemistry.chemical_classification ,Reactive oxygen species ,030109 nutrition & dietetics ,lcsh:TP368-456 ,food and beverages ,Polyphenols ,American cranberry ,food.food ,lcsh:Food processing and manufacture ,chemistry ,Polyphenol ,medicine.symptom ,Mitochondrial dysfunction ,Adenosine triphosphate ,lcsh:Nutrition. Foods and food supply ,Oxidative stress ,Food Science - Abstract
The American cranberry (Vaccinium macrocarpon) is one of the fruits containing antioxidants in great quantity and of high quality. From recent research, it is evident that both cranberry and its products, when consumed chronically or acutely, boost the antioxidant effect. Likewise, most studies revealed the anti-inflammatory potential of the cranberry polyphenols. Both effects exert direct action mechanisms, revealed by the ability of the polyphenols to remove the reactive oxygen species, as well as indirect effects, represented by the action of these phytochemicals on the cell signaling pathways and genetic expression. A limited number of articles that evaluated the effects of cranberry on mitochondrial damages are available. However, an enhancement in the functions of this organelle was confirmed by the increased production of adenosine triphosphate (ATP). Therefore, further studies are required to demonstrate the benefits credited to the use of cranberry, as well as to describe the action mechanisms of the polyphenols.
- Published
- 2018
9. Effect of Chia (Salvia hispanica L.) Flour on Glycemic Response and Energy Intake in Healthy Adults (P06-099-19)
- Author
-
Priscila Vaz de Melo Ribeiro, Rita de Cássia Gonçalves Alfenas, Bárbara Pereira da Silva, Daniela Mayumi Usuda Prado Rocha, Alessandra da Silva, Ana Paula Silva Caldas, Olívia Gonçalves Leão Coelho, and Alinne Paula de Almeida
- Subjects
Nutrition and Dietetics ,Calorie ,Traditional medicine ,biology ,business.industry ,Salvia hispanica ,Ethics committee ,Medicine (miscellaneous) ,Dietary Bioactive Components ,Salvia ,biology.organism_classification ,medicine.disease ,food.food ,food ,Diabetes mellitus ,Area under curve ,Medicine ,business ,Food Science ,Glycemic - Abstract
OBJECTIVES: Postprandial glycemic control is essential in both healthy and diabetic people, as hyperglycemia predisposes to complications associated with diabetes. The consumption of fiber-rich meals help to prevent and control undesirable glycemic changes. This study aimed to evaluate the effect of one-day consumption of chia on glycemic response and energy intake in healthy adults. METHODS: Single-blind, randomized, crossover design study involving healthy adults, normal weight (BMI 18.5–24.9 kg/m(2)), euglycemic (100 mg/dL), with no diabetes family history. They attended to the laboratory after 10–12 h fasting and received either 350 ml of a shake containing 10 g of chia flour (4.44 g of fiber) or 350 ml of a control shake (1.1 g of fiber)- similar in calories and macronutrients, containing 51 g of available carbohydrate - on two non-consecutive days (washout period). At each testing day, 60 minutes after shake intake a glucose solution (25 g) was provided. Capillary blood glucose was measured in fasting state (−60 min), immediately before (0 min), and 15, 30, 45, 60, 90, 120 minutes after glucose load. In addition, food intake was assessed 24-hour dietary recall was performed after each testing day. Habitual dietary intake was estimated using the semi-quantitative QFCA. The study was approved by the Local Ethics Committee. Repeated-measures ANOVA test was used to compare habitual dietary intake and consumption after shake. Two-way repeated measures ANOVA test followed by Bonferroni's post-hoc was used to assess the differences in postprandial blood glucose. Incremental area under the curve (AUC) of postprandial glycemia was calculated using the trapezoidal rule and paired sample t-test was used to compare them. All analyses were conducted using SPSS software. Statistical significance was set as p 0.05) nor food intake (p > 0.05) among adults (25 ± 1 years), euglycemic (87.88 ± 1.21 mg/dL), normal weight (21.06 ± 0.28 kg/m(2) and 23.23 ± 1.19% body fat percentual). CONCLUSIONS: The one-day consumption of chia flour did not affect the glycemic response and did not interfere in energy intake in healthy individuals. The long-term effect of chia should be assessed. FUNDING SOURCES: CNPq, CAPES, FAPEMIG, FUNARBE, DNS-UFV. SUPPORTING TABLES, IMAGES AND/OR GRAPHS
- Published
- 2019
10. Consumption of extra virgin olive oil improves body composition and blood pressure in women with excess body fat: a randomized, double-blinded, placebo-controlled clinical trial
- Author
-
Laís Emilia da Silva, Rita de Cássia Gonçalves Alfenas, Flávia Xavier Valente, Maria do Carmo Gouveia Peluzio, Flávia Galvão Cândido, and Olívia Gonçalves Leão Coelho
- Subjects
Adult ,food.ingredient ,Medicine (miscellaneous) ,Adipose tissue ,030209 endocrinology & metabolism ,Blood Pressure ,030204 cardiovascular system & hematology ,Placebo ,Soybean oil ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Animal science ,food ,Double-Blind Method ,Extra virgin olive oil ,medicine ,Humans ,Plant Oils ,Food science ,Obesity ,Olive Oil ,Monounsaturated fatty acid ,Adiposity ,Creatinine ,Nutrition and Dietetics ,business.industry ,Anthropometry ,medicine.disease ,Blood pressure ,chemistry ,Adipose Tissue ,Body fat ,Body Composition ,Composition (visual arts) ,Female ,business - Abstract
Despite the fact that extra virgin olive oil (EVOO) is widely used in obese individuals to treat cardiovascular diseases, the role of EVOO on weight/fat reduction remains unclear. We investigated the effects of energy-restricted diet containing EVOO on body composition and metabolic disruptions related to obesity. This is a randomized, double-blinded, placebo-controlled clinical trial in which 41 adult women with excess body fat (mean ± SD 27.0 ± 0.9 year old, 46.8 ± 0.6% of total body fat) received daily high-fat breakfasts containing 25 mL of soybean oil (control group, n = 20) or EVOO (EVOO group, n = 21) during nine consecutive weeks. Breakfasts were part of an energy-restricted normal-fat diets (−2090 kJ, ~32%E from fat). Anthropometric and dual-energy X-ray absorptiometry were assessed, and fasting blood was collected on the first and last day of the experiment. Fat loss was ~80% higher on EVOO compared to the control group (mean ± SE: −2.4 ± 0.3 kg vs. −1.3 ± 0.4 kg, P = 0.037). EVOO also reduced diastolic blood pressure when compared to control (–5.1 ± 1.6 mmHg vs. +0.3 ± 1.2 mmHg, P = 0.011). Within-group differences (P < 0.050) were observed for HDL-c (−2.9 ± 1.2 mmol/L) and IL-10 (+0.9 ± 0.1 pg/mL) in control group, and for serum creatinine (+0.04 ± 0.01 µmol/L) and alkaline phosphatase (−3.3 ± 1.8 IU/L) in the EVOO group. There was also a trend for IL-1β EVOO reduction (−0.3 ± 0.1 pg/mL, P = 0.060). EVOO consumption reduced body fat and improved blood pressure. Our results indicate that EVOO should be included into energy-restricted programs for obesity treatment.
- Published
- 2017
11. Polyunsaturated fatty acids and type 2 diabetes: Impact on the glycemic control mechanism
- Author
-
Olívia Gonçalves Leão Coelho, Bárbara Pereira da Silva, Rita de Cássia Gonçalves Alfenas, Lílian Lelis Lopes, and Daniela Mayumi Usuda Prado Rocha
- Subjects
0301 basic medicine ,Blood Glucose ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Type 2 diabetes ,Carbohydrate metabolism ,Industrial and Manufacturing Engineering ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,Fatty Acids, Omega-3 ,Medicine ,Humans ,Glycemic ,chemistry.chemical_classification ,030109 nutrition & dietetics ,business.industry ,Mechanism (biology) ,Type 2 Diabetes Mellitus ,General Medicine ,Fasting ,medicine.disease ,Alternative treatment ,Endocrinology ,chemistry ,Diabetes Mellitus, Type 2 ,Fatty Acids, Unsaturated ,business ,Food Science ,Polyunsaturated fatty acid - Abstract
There is a growing mortality related to co-morbidities associated with diabetes mellitus. Intake of polyunsaturated fatty acids (PUFA) has been associated with low cardiometabolic risk and reduction of inflammatory process. The objective of this paper is to review the impact of PUFA intake on glycemic control in diabetic patients as well as to elucidate the possible mechanisms involved. Medline/PubMed electronic database was searched to identify studies published within last five years regarding the effect of PUFA intake on glucose metabolism in type 2 diabetics. The search terms used were "polyunsaturated fatty acid(s)," "PUFA," and "diabetes." We included only interventional studies that assessed the effects of PUFA intake on glucose metabolism - fasting glucose, serum insulin, HbA1c, and HOMA-IR assessment- in type 2 diabetics. Initially, 48 articles were identified, of which one was not available and 41 did not match the inclusion criteria. Within the selected studies, three articles showed an improvement in fasting blood glucose, two showed an increase in fasting glycemia, and there was no effect of intervention in one article only. Based on the analyzed clinical interventional studies, supplementation of 0.42-5.2-g PUFA/day for at least eight weeks may become an alternative treatment for type 2 diabetes mellitus, particularly in Asian subjects.
- Published
- 2016
12. CARACTERIZAÇÃO ANATÔMICA, COMPOSIÇÃO MINERAL E ATIVIDADE CITOTÓXICA DE Talinum triangulare (Jacq.) Willd (PORTULACACEAE)
- Author
-
Joseane Bessa Barbosa, Beatriz Gonçalves Brasileiro, Virgínia Ramos Pizziolo, Claudia Masrouh Jamal, Rikeller Ronchi, and Olívia Gonçalves Leão Coelho
- Subjects
food.ingredient ,Epidermis (botany) ,Cuticle ,Biology ,biology.organism_classification ,Vascular bundle ,food ,Phytochemical ,Botany ,Parenchyma ,General Earth and Planetary Sciences ,Talinum triangulare ,Artemia salina ,Portulacaceae ,General Environmental Science - Abstract
This study aimed to assess chemical compositions and anatomy of Talinum triangulare extract and its cytotoxic activity in order to improve the knowledge of the specie. Leaves and stem fragments were fixed, sectioned and stained following the usual techniques in anatomy. The phytochemical screening was performed according to classical tests for secondary metabolites detection. Cytotoxicity was evaluated using as model the lethality of Artemia salina larvae. The studied leaf is amphistomatic and presents uniseriate epidermis covered by thin cuticle. The mesophyll is dorsiventral and the midrib consists of collateral vascular bundle. In the apical portion, the stem has vascular bundles delimiting the medular and cortical regions. A stratum of angular collenchyma is found beneath the epidermis. In the basal portion, the stem has about four layers of angular collenchyma and voluminous parenchyma cells internally delimiting the cortex. The phytochemical screening detects the presence of alkaloids, flavonoids, coumarins, terpenes and steroids. The mineral composition showed that the major element found was nitrogen, followed by potassium and magnesium, and the leaves are iron rich. The ethanolic extract did not show toxicity in the larvae of A. salina, with LD50> 1000 ppm, which proves the safe use of this specie in popular therapy.
- Published
- 2016
13. Cranberry antioxidant power on oxidative stress, inflammation and mitochondrial damage
- Author
-
Ana Paula Silva Caldas, Olivia Gonçalves Leão Coelho, and Josefina Bressan
- Subjects
Antioxidants ,Free radicals ,Inflammation ,Mitochondrial dysfunction ,Polyphenols ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
The American cranberry (Vaccinium macrocarpon) is one of the fruits containing antioxidants in great quantity and of high quality. From recent research, it is evident that both cranberry and its products, when consumed chronically or acutely, boost the antioxidant effect. Likewise, most studies revealed the anti-inflammatory potential of the cranberry polyphenols. Both effects exert direct action mechanisms, revealed by the ability of the polyphenols to remove the reactive oxygen species, as well as indirect effects, represented by the action of these phytochemicals on the cell signaling pathways and genetic expression. A limited number of articles that evaluated the effects of cranberry on mitochondrial damages are available. However, an enhancement in the functions of this organelle was confirmed by the increased production of adenosine triphosphate (ATP). Therefore, further studies are required to demonstrate the benefits credited to the use of cranberry, as well as to describe the action mechanisms of the polyphenols.
- Published
- 2018
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.