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4. Detailed Characteristics of Post-discharge Mortality in Acute Pancreatitis

Author

Hegyi, Péter Jenő, Párniczky, Andrea, Földi, Mária, Ocskay, Klementina, Juhász, Márk Félix, Imrei, Marcell, Kiss, Szabolcs, Mikó, Alexandra, Gódi, Szilárd, Bajor, Judit, Hágendorn, Roland, Sarlós, Patrícia, Szabó, Imre, Czimmer, József, Faluhelyi, Nándor, Kanizsai, Péter, Miseta, Attila, Nagy, Tamás, Gajdán, László, Halász, Adrienn, Németh, Balázs, Kui, Balázs, Illés, Dóra, Takács, Tamás, Tiszlavicz, László, Oláh-Németh, Orsolya, Radics, Bence, Vitális, Zsuzsanna, Hamvas, József, Varga, Márta, Bod, Barnabás, Novák, János, Maurovich-Horváth, Pál, Doros, Attila, Deák, Pál Ákos, Varga, Csaba, Gaál, Szabolcs, Zubek, László, Gál, János, Molnár, Zsolt, Tornai, Tamás, Lázár, Balázs, Hussein, Tamás, Kovács, Bea, Németh, Anna, Tarján, Dorottya, Lipp, Mónika, Urbán, Orsolya, Tóth, Simon, Söti, Dániel, Becker, Dávid, Czapári, Dóra, Váradi, Alex, Farkas, Nelli, Nyári, Gergely, Márta, Katalin, Váncsa, Szilárd, Nagy, Rita, Teutsch, Brigitta, Bunduc, Stefania, Erőss, Bálint, Czakó, László, Vincze, Áron, Izbéki, Ferenc, Papp, Mária, Merkely, Béla, Szentesi, Andrea, and Hegyi, Péter

Published
2023
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6. Predictive Potential of RNA Polymerase B (II) Subunit 1 (RPB1) Cytoplasmic Aggregation for Neoadjuvant Chemotherapy Failure

Author

Nagy-Mikó, Bence, primary, Németh-Szatmári, Orsolya, additional, Faragó-Mészáros, Réka, additional, Csókási, Aliz, additional, Bognár, Bence, additional, Ördög, Nóra, additional, Borsos, Barbara N., additional, Majoros, Hajnalka, additional, Ujfaludi, Zsuzsanna, additional, Oláh-Németh, Orsolya, additional, Nikolényi, Aliz, additional, Dobi, Ágnes, additional, Kószó, Renáta, additional, Sántha, Dóra, additional, Lázár, György, additional, Simonka, Zsolt, additional, Paszt, Attila, additional, Ormándi, Katalin, additional, Pankotai, Tibor, additional, Boros, Imre M., additional, Villányi, Zoltán, additional, and Vörös, András, additional

Published
2023
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7. Does Diffusely Infiltrating Lobular Carcinoma of the Breast Arise from Epithelial–Mesenchymal Hybrid Cells?

Author

Tabár, László, primary, Bozó, Renáta, additional, Dean, Peter B., additional, Ormándi, Katalin, additional, Puchkova, Olga, additional, Oláh-Németh, Orsolya, additional, Németh, István Balázs, additional, Veréb, Zoltán, additional, Yen, Ming-Fang, additional, Chen, Li-Sheng, additional, Chen, Hsiu-Hsi, additional, and Vörös, András, additional

Published
2023
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9. ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations

Author

Cserni, Bálint, Kilmartin, Darren, O’Loughlin, Mark, Andreu, Xavier, Bagó-Horváth, Zsuzsanna, Bianchi, Simonetta, Chmielik, Ewa, Figueiredo, Paulo, Floris, Giuseppe, Foschini, Maria Pia, Kovács, Anikó, Heikkilä, Päivi, Kulka, Janina, Laenkholm, Anne Vibeke, Liepniece-Karele, Inta, Marchiò, Caterina, Provenzano, Elena, Regitnig, Peter, Reiner, Angelika, Ryška, Aleš, Sapino, Anna, Stovgaard, Elisabeth Specht, Quinn, Cecily, Zolota, Vasiliki, Webber, Mark, Glynn, Sharon A., Bori, Rita, Csörgő, Erika, Oláh-Németh, Orsolya, Pancsa, Tamás, Sejben, Anita, Sejben, István, Vörös, András, Zombori, Tamás, Nyári, Tibor, Callagy, Grace, Cserni, Gábor, Cserni, Bálint, Kilmartin, Darren, O’Loughlin, Mark, Andreu, Xavier, Bagó-Horváth, Zsuzsanna, Bianchi, Simonetta, Chmielik, Ewa, Figueiredo, Paulo, Floris, Giuseppe, Foschini, Maria Pia, Kovács, Anikó, Heikkilä, Päivi, Kulka, Janina, Laenkholm, Anne Vibeke, Liepniece-Karele, Inta, Marchiò, Caterina, Provenzano, Elena, Regitnig, Peter, Reiner, Angelika, Ryška, Aleš, Sapino, Anna, Stovgaard, Elisabeth Specht, Quinn, Cecily, Zolota, Vasiliki, Webber, Mark, Glynn, Sharon A., Bori, Rita, Csörgő, Erika, Oláh-Németh, Orsolya, Pancsa, Tamás, Sejben, Anita, Sejben, István, Vörös, András, Zombori, Tamás, Nyári, Tibor, Callagy, Grace, and Cserni, Gábor

Abstract

Tumour-infiltrating lymphocytes (TILs) reflect antitumour immunity. Their evaluation of histopathology specimens is influenced by several factors and is subject to issues of reproducibility. ONEST (Observers Needed to Evaluate Subjective Tests) helps in determining the number of observers that would be sufficient for the reliable estimation of inter-observer agreement of TIL categorisation. This has not been explored previously in relation to TILs. ONEST analyses, using an open-source software developed by the first author, were performed on TIL quantification in breast cancers taken from two previous studies. These were one reproducibility study involving 49 breast cancers, 23 in the first circulation and 14 pathologists in the second circulation, and one study involving 100 cases and 9 pathologists. In addition to the estimates of the number of observers required, other factors influencing the results of ONEST were examined. The analyses reveal that between six and nine observers (range 2–11) are most commonly needed to give a robust estimate of reproducibility. In addition, the number and experience of observers, the distribution of values around or away from the extremes, and outliers in the classification also influence the results. Due to the simplicity and the potentially relevant information it may give, we propose ONEST to be a part of new reproducibility analyses.

Published
2023

10. ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations

Author

Cserni, Bálint, primary, Kilmartin, Darren, additional, O’Loughlin, Mark, additional, Andreu, Xavier, additional, Bagó-Horváth, Zsuzsanna, additional, Bianchi, Simonetta, additional, Chmielik, Ewa, additional, Figueiredo, Paulo, additional, Floris, Giuseppe, additional, Foschini, Maria Pia, additional, Kovács, Anikó, additional, Heikkilä, Päivi, additional, Kulka, Janina, additional, Laenkholm, Anne-Vibeke, additional, Liepniece-Karele, Inta, additional, Marchiò, Caterina, additional, Provenzano, Elena, additional, Regitnig, Peter, additional, Reiner, Angelika, additional, Ryška, Aleš, additional, Sapino, Anna, additional, Stovgaard, Elisabeth Specht, additional, Quinn, Cecily, additional, Zolota, Vasiliki, additional, Webber, Mark, additional, Glynn, Sharon A., additional, Bori, Rita, additional, Csörgő, Erika, additional, Oláh-Németh, Orsolya, additional, Pancsa, Tamás, additional, Sejben, Anita, additional, Sejben, István, additional, Vörös, András, additional, Zombori, Tamás, additional, Nyári, Tibor, additional, Callagy, Grace, additional, and Cserni, Gábor, additional

Published
2023
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11. Cytoplasmic Aggregation of RPB1 Predicts Failure of Neoadjuvant Chemotherapy

Author

Nagy-Mikó, Bence, primary, Németh-Szatmári, Orsolya, additional, Faragó-Mészáros, Réka, additional, Csókási, Aliz, additional, Bognár, Bence, additional, Ördög, Nóra, additional, Borsos, Barbara N., additional, Majoros, Hajnalka, additional, Ujfaludi, Zsuzsanna, additional, Oláh-Németh, Orsolya, additional, Nikolényi, Aliz, additional, Dobi, Ágnes, additional, Kószó, Renáta, additional, Sántha, Dóra, additional, Lázár, György, additional, Simonka, Zsolt, additional, Paszt, Attila, additional, Ormándi, Katalin, additional, Pankotai, Tibor, additional, Boros, Imre M., additional, Villányi, Zoltán, additional, and Vörös, András, additional

Published
2023
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13. ONEST (Observers Needed to Evaluate Subjective Tests) suggests four or more observers for a reliable assessment of the consistency of histological grading of invasive breast carcinoma: A reproducibility study with a retrospective view on previous studies

Author

Cserni, Bálint, primary, Bori, Rita, additional, Csörgő, Erika, additional, Oláh-Németh, Orsolya, additional, Pancsa, Tamás, additional, Sejben, Anita, additional, Sejben, István, additional, Vörös, András, additional, Zombori, Tamás, additional, Nyári, Tibor, additional, and Cserni, Gábor, additional

Published
2022
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14. BC-Monitor: Towards a Routinely Accessible Circulating Tumor DNA-Based Tool for Real-Time Monitoring Breast Cancer Progression and Treatment Effectiveness

Author

Priskin, Katalin, primary, Pólya, Sára, additional, Pintér, Lajos, additional, Jaksa, Gábor, additional, Csányi, Bernadett, additional, Enyedi, Márton Zsolt, additional, Sági-Zsigmond, Eszter, additional, Sükösd, Farkas, additional, Oláh-Németh, Orsolya, additional, Kelemen, Gyöngyi, additional, Nikolényi, Alíz, additional, Uhercsák, Gabriella, additional, Sántha, Dóra, additional, Dobi, Ágnes, additional, Szilágyi, Éva, additional, Valicsek, Erzsébet, additional, Tordai, László, additional, Tóth, Rozália, additional, Kahán, Zsuzsanna, additional, and Haracska, Lajos, additional

Published
2021
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15. ONEST (Observers Needed to Evaluate Subjective Tests) suggests four or more observers for a reliable assessment of the consistency of histological grading of invasive breast carcinoma: A reproducibility study with a retrospective view on previous studies.

Author

Cserni B, Bori R, Csörgő E, Oláh-Németh O, Pancsa T, Sejben A, Sejben I, Vörös A, Zombori T, Nyári T, and Cserni G

Subjects
Biopsy, Large-Core Needle, Female, Humans, Neoplasm Grading, Neoplasm Invasiveness, Reproducibility of Results, Retrospective Studies, Breast Neoplasms pathology, Observer Variation
Abstract

Histological grade is one of the most important prognosticators of breast cancer which is available for nearly all cases. It also makes part of several multivariable analysis derived combined prognostic profiles despite concerns about its reproducibility. The aims included a reproducibility study of grading in the light of a recently described statistical approach, ONEST (Observers Needed to Evaluate Subjective Tests) and review earlier reproducibility studies in the light of the ONEST analysis. Nine pathologists reviewed 50 core needle biopsies and 50 slides from different excision specimens and recorded the scores for gland (tubule) formation, nuclear pleomorphism and mitotic activity as well as histological grade. Overall percent agreement, Fleiss kappa and the intraclass correlation coefficient (ICC) were used for the analysis of reproducibility. ONEST data and curves were generated from 100 random permutations of the participants. ONEST suggested a minimum of 4 observers for the reliable evaluation of reproducibility for both the scored components and grade in either type of specimen. Our results suggested moderate or moderate to good reproducibility of grading (kappa values of 0.51 for excisions, and 0.54 for biopsies and ICCs of 0.70 and 0.69, respectively) with gland formation being the most and nuclear pleomorphism the worst consistently evaluated feature. In studies with sufficient participants (at least 4) and non-pairwise comparisons in the analysis, the reproducibility of histological grading is fair to moderate, whereas studies with fewer participants or pairwise kappa analysis suggest moderate to almost prefect agreement of the results. ONEST is a valuable complementation of reproducibility analyses., (Copyright © 2021 The Authors. Published by Elsevier GmbH.. All rights reserved.)

Published
2022
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