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Your search keyword '"Okumura, Maiko"' showing total 22 results
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22 results on '"Okumura, Maiko"'

2. A Case of Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis Overlap Syndrome

Author

Hounoki, Hiroyuki, Shinoda, Koichiro, Matsui, Atsushi, Okumura, Maiko, Yamaguchi, Satoshi, Kakeshita, Kota, Yamazaki, Hidenori, Koike, Tsutomu, Makino, Teruhiko, and Tobe, Kazuyuki

Subjects
Article Subject, immune system diseases, urologic and male genital diseases, skin and connective tissue diseases
Abstract

An overlap of systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic antibodies- (ANCA-) associated vasculitis (AAV) is extremely rare: approximately 40 cases have been reported to date. A literature review indicates that they are more common in women in their forties, and simultaneous onset has been reported in 69% of cases. In addition, both lupus nephritis and ANCA-associated glomerulonephritis were observed on renal biopsy. This report presents the case of a 35-year-old woman with an 8-month history of polyarthralgia who was admitted to our hospital. She was diagnosed with SLE due to typical clinical presentation of the disease: polyarthritis, lymphocytopenia, hypocomplementemia, presence of antinuclear and anti-dsDNA antibodies, and proteinuria. However, purpura were scattered, and the titer of antimyeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCA) was high. A skin biopsy revealed leukocytoclastic vasculitis that involved poor immune complex deposition. A renal biopsy showed necrotizing glomerulonephritis with cellular and fibrocellular crescent formation that involved deposition of IgM and C3c only in the mesangial area and the peripheral capillaries. Additionally, no electron-dense deposits were observed under electron microscopy. These pathological findings were consistent with AAV rather than with SLE. Therefore, we finally diagnosed the patient with both SLE and microscopic polyangiitis. After treatment with methylprednisolone and intravenous cyclophosphamide pulse therapies, renal function improved and MPO-ANCA levels decreased. In cases of suspected overlap between SLE and AAV, appropriate diagnosis and treatment are important.

Published
2021
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6. Stereodivergent process for the synthesis of the decahydroquinoline type of dendrobatid alkaloids

Author

Toyooka, Naoki, Okumura, Maiko, and Nemoto, Hideo

Subjects
Chemistry, Organic -- Research, Stereochemistry -- Research, Quinoline -- Physiological aspects, Hydrogen -- Physiological aspects, Alkaloids -- Physiological aspects, Esters -- Physiological aspects, Amines -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the cis- and trans-disubstituted octahydroquinolinone ring systems with stereogenic centers. The stereodivergent synthesis of these systems has been carried out via the stereodivergent and stereoselective construction of trisubstituted piperidine ring systems using Michael addition reaction to enaminoesters.

Published
2002

11. Autoantibodies reactive to PEP08 are clinically related with morbidity and severity of interstitial lung disease in connective tissue diseases

Author

Okumura, Maiko, primary, Ozawa, Tatsuhiko, additional, Hamana, Hiroshi, additional, Norimatsu, Yu, additional, Tsuda, Reina, additional, Kobayashi, Eiji, additional, Shinoda, Koichiro, additional, Taki, Hirofumi, additional, Tobe, Kazuyuki, additional, Imura, Johji, additional, Sugiyama, Eiji, additional, Kishi, Hiroyuki, additional, and Muraguchi, Atsushi, additional

Published
2018
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14. Enantioselective total synthesis of the marine alkaloid lepadin

Author

Toyooka, Naoki, Okumura, Maiko, and Takahata, Hiroki

Subjects
Alkaloids -- Research, Ring formation (Chemistry) -- Research, Organic compounds -- Synthesis, Biological sciences, Chemistry
Abstract

A study was conducted to analyze the preparation of the cis hexahydroquinolinone ring system using an intramolecular aldol type of cyclization of the functionalized piperidine supporting the epimerization at the C-3 position. An enone was subjected to conjugate addition of the anion produced from phenylthiomethyl phenyl sulfone. Results indicated that the absolute stereochemistry of lepadin B was 2S,3S,-4aS,5S,8aR.

Published
1999

18. .ALPHA.-Bromo-.ALPHA.,.ALPHA.-difluoroallyl Derivatives as Synthetic Intermediate. Nucleophilic Substitution of .ALPHA.-Bromo-.ALPHA.,.ALPHA.-difluoroallyl Derivatives in the Presence of Palladium Catalysts.

Author

KIRIHARA, Masayuki, primary, TAKUWA, Tomofumi, additional, OKUMURA, Maiko, additional, WAKIKAWA, Takahiro, additional, TAKAHATA, Hiroki, additional, MOMOSE, Takefumi, additional, TAKEUCHI, Yoshio, additional, and NEMOTO, Hideo, additional

Published
2000
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