12,032 results on '"Oksanen A"'
Search Results
2. Rigidity in the Lorentzian Calder\'on problem with formally determined data
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Oksanen, Lauri, Rakesh, and Salo, Mikko
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Mathematics - Analysis of PDEs ,Mathematical Physics ,Mathematics - Differential Geometry - Abstract
We study the Lorentzian Calder\'on problem, where the objective is to determine a globally hyperbolic Lorentzian metric up to a boundary fixing diffeomorphism from boundary measurements given by the hyperbolic Dirichlet-to-Neumann map. This problem is a wave equation analogue of the Calder\'on problem on Riemannian manifolds. We prove that if a globally hyperbolic metric agrees with the Minkowski metric outside a compact set and has the same hyperbolic Dirichlet-to-Neumann map as the Minkowski metric, then it must be the Minkowski metric up to diffeomorphism. In fact we prove the same result with a much smaller amount of measurements, thus solving a formally determined inverse problem. To prove these results we introduce a new method for geometric hyperbolic inverse problems. The method is based on distorted plane wave solutions and on a combination of geometric, topological and unique continuation arguments., Comment: 39 pages, 2 figures
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- 2024
3. The backscattering problem for time-dependent potentials
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Nursultanov, Medet, Oksanen, Lauri, and Stefanov, Plamen
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Mathematics - Analysis of PDEs ,35P25, 35R30 - Abstract
We study the inverse backscattering problem for time-dependent potentials. We prove uniqueness and Lipshitz stability for the recovery of small potentials.
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- 2024
4. Linearized Boundary Control Method for Density Reconstruction in Acoustic Wave Equations
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Oksanen, Lauri, Yang, Tianyu, and Yang, Yang
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Mathematics - Analysis of PDEs ,35R30, 35L05 - Abstract
We develop a linearized boundary control method for the inverse boundary value problem of determining a density in the acoustic wave equation. The objective is to reconstruct an unknown perturbation in a known background density from the linearized Neumann-to-Dirichlet map. A key ingredient in the derivation is a linearized Blagovescenskii's identity with a free parameter. When the linearization is at a constant background density, we derive two reconstructive algorithms with stability estimates based on the boundary control method. When the linearization is at a non-constant background density, we establish an increasing stability estimate for the recovery of the density perturbation. The proposed reconstruction algorithms are implemented and validated with several numerical experiments to demonstrate the feasibility., Comment: 22 pages, 6 figures. arXiv admin note: text overlap with arXiv:2112.10976
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- 2024
5. Solving the unique continuation problem for Schr\'odinger equations with low regularity solutions using a stabilized finite element method
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Burman, Erik, Lu, Mingfei, and Oksanen, Lauri
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Mathematics - Numerical Analysis - Abstract
In this paper, we consider the unique continuation problem for the Schr\"odinger equations. We prove a H\"older type conditional stability estimate and build up a parameterized stabilized finite element scheme adaptive to the \textit{a priori} knowledge of the solution, achieving error estimates in interior domains with convergence up to continuous stability. The approximability of the scheme to solutions with only $H^1$-regularity is studied and the convergence rate for solutions with regularity higher than $H^1$ is also shown. Comparisons in terms of different parameterization for different regularities will be illustrated with respect to the convergence and condition numbers of the linear systems. Finally, numerical experiments will be given to illustrate the theory.
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- 2024
6. What are escapists made of, and what does it have to do with excessive gambling and gaming?
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Jouhki, Hannu, Savolainen, Iina, Hagfors, Heli, Vuorinen, Ilkka, and Oksanen, Atte
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- 2024
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7. Computational unique continuation with finite dimensional Neumann trace
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Burman, Erik, Oksanen, Lauri, and Zhao, Ziyao
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Mathematics - Numerical Analysis ,65N20 - Abstract
We consider finite element approximations of unique continuation problems subject to elliptic equations in the case where the normal derivative of the exact solution is known to reside in some finite dimensional space. To give quantitative error estimates we prove Lipschitz stability of the unique continuation problem in the global H1-norm. This stability is then leveraged to derive optimal a posteriori and a priori error estimates for a primal-dual stabilised finite method.
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- 2024
8. Effects of resonances and surface texturing on light emission in emerging thin-film devices
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Kivisaari, Pyry, Partanen, Mikko, and Oksanen, Jani
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Physics - Optics - Abstract
Recent developments in thin-film fabrication and processing open up interesting possibilities for both established and emerging optics technologies. There, one of the key questions requiring more complete understanding is by how much one can improve the performance of thin-film devices by utilizing resonance effects and surface texturation. In this work, we report on our recent theoretical investigations around two aspects of this question: (1) how much the overall (=angle and energy-integrated) emission of extremely thin ($\sim10$ nm) layers can be enhanced through cavity effects, and (2) how much resonances affect the emission of moderately thin ($>100$ nm) layers in a typical device interacting with free space (in this case an ultra-thin solar cell). Beginning with topic (1), we find that the total emission of active layers with thicknesses $<50$ nm in particular can be boosted through resonant effects by placing them in a cavity. For topic (2), the results indicate that a radiative transfer approach (i.e., one not accounting for resonant effects) can give even quantitatively accurate predictions of the total emission of moderately thin layers in a thin-film device, as long as the reflectances of the device's outer boundaries are known, and the emitting layer is not very close to optical elements supporting direct evanescent coupling (such as metal mirrors). Finally, we demonstrate that extending the self-consistent radiative transfer--drift-diffusion approach for diffusive scattering presents an interesting tool to optimize thin-film devices even with textured surfaces.
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- 2024
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9. Detection of Dirofilaria immitis in a brown bear (Ursus arctos) in Greece
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Papadopoulos E., Komnenou A., Poutachides T., Heikkinen P., Oksanen A., and Karamanlidis A. A.
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dirofilaria immitis ,brown bear ,conservation threats ,epidemiology ,heartworm ,Microbiology ,QR1-502 - Abstract
Dirofilaria immitis (canine heartworm) is a filarial nematode found in the pulmonary circulation and the heart of susceptible hosts. It represents an important zoonotic vector-borne disease of domestic dogs and several wildlife species. Herein we report for the first time, the finding of Dirofilaria immitis worms in a brown bear killed in a vehicle collision in Northern Greece. The worms were morphologically identified; molecular examination, based on the analysis of the mitochondrial genes 12S (433 bp) and CO1 (610 bp), verified the identification by demonstrating 100% similarity to D. immitis specimens deposited in GenBank. Brown bears in Greece occupy habitats that are shared with the potential wild and domestic hosts and the vectors of D. immitis and thus may be particularly susceptible to this parasite. This report contributes to the knowledge of dirofilariosis spread in Europe and on the epidemiological threats that may affect the survival of the endangered brown bear in Greece.
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- 2017
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10. Retrieving Yang–Mills–Higgs fields in Minkowski space from active local measurements
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Chen, Xi, Lassas, Matti, Oksanen, Lauri, and Paternain, Gabriel P.
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- 2024
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11. Gambling Motives and Offshore Gambling: A Finnish Population Study
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Hagfors, Heli, Oksanen, Atte, and Salonen, Anne H.
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- 2024
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12. Optimal finite element approximation of unique continuation
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Burman, Erik, Nechita, Mihai, and Oksanen, Lauri
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Mathematics - Numerical Analysis ,Mathematics - Analysis of PDEs ,65N20 - Abstract
We consider finite element approximations of ill-posed elliptic problems with conditional stability. The notion of {\emph{optimal error estimates}} is defined including both convergence with respect to mesh parameter and perturbations in data. The rate of convergence is determined by the conditional stability of the underlying continuous problem and the polynomial order of the finite element approximation space. A proof is given that no finite element approximation can converge at a better rate than that given by the definition, justifying the concept. A recently introduced class of finite element methods with weakly consistent regularisation is recalled and the associated error estimates are shown to be quasi optimal in the sense of our definition.
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- 2023
13. Introduction to inverse problems for hyperbolic PDEs
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Nursultanov, Medet and Oksanen, Lauri
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Mathematics - Analysis of PDEs ,35R30 - Abstract
There are two main approaches to solve inverse coefficient determination problems for wave equations: the Boundary Control method and an approach based on geometric optics. These notes focus on the Boundary Control method, but we will have a brief look at the geometric optics as well., Comment: These lecture notes were written for CIRM SMF School Spectral Theory, Control and Inverse Problems, November 2022
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- 2023
14. Ready for O4 II: GRANDMA Observations of Swift GRBs during eight-weeks of Spring 2022
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Melo, I. Tosta e, Ducoin, J. -G., Vidadi, Z., Andrade, C., Rupchandani, V., Agayeva, S., Abdelhadi, J., Abe, L., Aguerre-Chariol, O., Aivazyan, V., Alishov, S., Antier, S., Bai, J. -M., Baransky, A., Bednarz, S., Bendjoya, Ph., Benkhaldoun, Z., Beradze, S., Bizouard, M. A., Bhardwaj, U., Blazek, M., Boër, M., Broens, E., Burkhonov, O., Christensen, N., Cooke, J., Corradi, W., Coughlin, M. W., Culino, T., Daigne, F., Dornic, D., Duverne, P. -A., Ehgamberdiev, S., Eymar, L., Fouad, A., Freeberg, M., Gendre, B., Guo, F., Gokuldass, P., Guessoum, N., Gurbanov, E., Hainich, R., Hasanov, E., Hello, P., Inasaridze, R., Iskandar, A., Ismailov, N., Janati, A., Laz, T. Jegou du, Kann, D. A., Karpov, S., Kiendrebeogo, R. W., Klotz, A., Kneip, R., Kochiashvili, N., Kaeouach, A., Kruiswijk, K., Lamoureux, M., Leroy, N., Lin, W. L., Mao, J., Marchais, D., Mašek, M., Midavaine, T., Moller, A., Morris, D., Natsvlishvili, R., Navarete, F., Guelbenzu, A Nicuesa, Noonan, K., Noysena, K., Oksanen, A., Orange, N. B., Pellouin, C., Peloton, J., Peng, H. W., Pilloix, M., Popowicz, A., Pradier, T., Pyshna, O., Raaijmakers, G., Rajabov, Y., Rau, A., Rinner, C., Rivet, J. -P., Ryh, A. S., Sabil, M., Sadibekova, T., Sasaki, N., Serrau, M., Simon, A., Shokry, A., Smith, K., Sokoliuk, O., Song, X., Takey, A., Thierry, P., Tillayev, Y., Turpin, D., Postigo, A. de Ugarte, Vasylenko, V., Vernet, D., Wang, L., Vachier, F., Vignes, J. P., Wang, X. F., Zeng, X., Zhang, J., and Zhu, Y.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present a campaign designed to train the GRANDMA network and its infrastructure to follow up on transient alerts and detect their early afterglows. In preparation for O4 II campaign, we focused on GRB alerts as they are expected to be an electromagnetic counterpart of gravitational-wave events. Our goal was to improve our response to the alerts and start prompt observations as soon as possible to better prepare the GRANDMA network for the fourth observational run of LIGO-Virgo-Kagra (which started at the end of May 2023), and future missions such as SM. To receive, manage and send out observational plans to our partner telescopes we set up dedicated infrastructure and a rota of follow-up adcates were organized to guarantee round-the-clock assistance to our telescope teams. To ensure a great number of observations, we focused on Swift GRBs whose localization errors were generally smaller than the GRANDMA telescopes' field of view. This allowed us to bypass the transient identification process and focus on the reaction time and efficiency of the network. During 'Ready for O4 II', 11 Swift/INTEGRAL GRB triggers were selected, nine fields had been observed, and three afterglows were detected (GRB 220403B, GRB 220427A, GRB 220514A), with 17 GRANDMA telescopes and 17 amateur astronomers from the citizen science project Kilonova-Catcher. Here we highlight the GRB 220427A analysis where our long-term follow-up of the host galaxy allowed us to obtain a photometric redshift of $z=0.82\pm0.09$, its lightcurve elution, fit the decay slope of the afterglows, and study the properties of the host galaxy.
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- 2023
15. Reciprocal of the CPT theorem
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Álvarez-Gaumé, Luis, Chaichian, Moshe M., Oksanen, Markku A., and Tureanu, Anca
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High Energy Physics - Theory ,High Energy Physics - Phenomenology - Abstract
The CPT theorem originally proven by L\"uders and Pauli ensures the equality of masses, lifetimes, magnetic moments and cross sections of any particle and its antiparticle. We show that in a Lorentz invariant quantum field theory described by its Lagrangian, CPT-violating interaction alone does not split the masses of an elementary particle and its antiparticle but breaks only the equality of lifetimes, magnetic moments and cross sections. However, CPT violation in the mass term of a field in the Lagrangian, which can be attributed to be due to the size of the particle described by a form factor, breaks only the equality of masses. Also it is shown that the two separate effects of CPT violation in the interaction terms or in the mass term do not mix due to higher quantum corrections and remain distinguishable. Thus, we urge the experimentalists to search for such observable effects concerning differences in the masses, magnetic moments, lifetimes and cross sections between the elementary or bound state particles and their antiparticles. In the case of CPT violation only in the mass term, besides the difference in the masses of elementary bound state particles and their antiparticles, there will be also an extremely tiny difference in the lifetimes of bound states due to the difference in their phase spaces. From the details of calculations, it appears that the separate effects of the CPT violation described above are quite general, neither depending on how the nonlocality is achieved, nor depending on what this violation is due to: due to T violation, as considered in the present work, which can be attributed to a cosmological direction of time; to CP or to both T and CP violations. The latter two cases satisfy the Sakharov's conditions for explaining the baryon asymmetry in the Universe., Comment: 12 pages; 1 figure; v3: two references added, one reference removed, minor corrections; to appear in Phys. Lett. B
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- 2023
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16. Stable recovery of coefficients in an inverse fault friction problem
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de Hoop, Maarten V., Lassas, Matti, Lu, Jinpeng, and Oksanen, Lauri
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Mathematics - Analysis of PDEs ,35R30, 35Q86 - Abstract
We consider the inverse fault friction problem of determining the friction coefficient in the Tresca friction model, which can be formulated as an inverse problem for differential inequalities. We show that the measurements of elastic waves during a rupture uniquely determine the friction coefficient at the rupture surface with explicit stability estimates., Comment: Final version with added details and corrections, to appear in Arch. Ration. Mech. Anal
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- 2023
17. Determining Lorentzian manifold from non-linear wave observation at a single point
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Nursultanov, Medet, Oksanen, Lauri, and Tzou, Leo
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Mathematics - Analysis of PDEs ,53C20, 35R30, 35L70 - Abstract
We consider an inverse problem for a non-linear hyperbolic equation. We show that conformal structure of a Lorentzian manifold can be determined by the source-to-solution map evaluated along a single timelike curve. We use the microlocal analysis of non-linear wave interaction.
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- 2023
18. Changes to virus taxonomy and the ICTV Statutes ratified by the International Committee on Taxonomy of Viruses (2024)
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Simmonds, Peter, Adriaenssens, Evelien M., Lefkowitz, Elliot J., Oksanen, Hanna M., Siddell, Stuart G., Zerbini, Francisco Murilo, Alfenas-Zerbini, Poliane, Aylward, Frank O., Dempsey, Donald M., Dutilh, Bas E., Freitas-Astúa, Juliana, García, María Laura, Hendrickson, R. Curtis, Hughes, Holly R., Junglen, Sandra, Krupovic, Mart, Kuhn, Jens H., Lambert, Amy J., Łobocka, Małgorzata, Mushegian, Arcady R., Penzes, Judit, Muñoz, Alejandro Reyes, Robertson, David L., Roux, Simon, Rubino, Luisa, Sabanadzovic, Sead, Smith, Donald B., Suzuki, Nobuhiro, Turner, Dann, Van Doorslaer, Koenraad, Vandamme, Anne-Mieke, and Varsani, Arvind
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- 2024
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19. Quantum refinement in real and reciprocal space using the Phenix and ORCA software
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Kristoffer J. M. Lundgren, Octav Caldararu, Esko Oksanen, and Ulf Ryde
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x-ray crystallography ,neutron crystallography ,cryo-em ,quantum refinement ,qm/mm ,fe-nitrogenase ,v-nitrogenase ,mn superoxide dismutase ,particulate methane monooxygenase ,Crystallography ,QD901-999 - Abstract
X-ray and neutron crystallography, as well as cryogenic electron microscopy (cryo-EM), are the most common methods to obtain atomic structures of biological macromolecules. A feature they all have in common is that, at typical resolutions, the experimental data need to be supplemented by empirical restraints, ensuring that the final structure is chemically reasonable. The restraints are accurate for amino acids and nucleic acids, but often less accurate for substrates, inhibitors, small-molecule ligands and metal sites, for which experimental data are scarce or empirical potentials are harder to formulate. This can be solved using quantum mechanical calculations for a small but interesting part of the structure. Such an approach, called quantum refinement, has been shown to improve structures locally, allow the determination of the protonation and oxidation states of ligands and metals, and discriminate between different interpretations of the structure. Here, we present a new implementation of quantum refinement interfacing the widely used structure-refinement software Phenix and the freely available quantum mechanical software ORCA. Through application to manganese superoxide dismutase and V- and Fe-nitrogenase, we show that the approach works effectively for X-ray and neutron crystal structures, that old results can be reproduced and structural discrimination can be performed. We discuss how the weight factor between the experimental data and the empirical restraints should be selected and how quantum mechanical quality measures such as strain energies should be calculated. We also present an application of quantum refinement to cryo-EM data for particulate methane monooxygenase and show that this may be the method of choice for metal sites in such structures because no accurate empirical restraints are currently available for metals.
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- 2024
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20. Social Capital And The Use Of Health Services: A Cross-Sectional Study Among Brazilian Older Adults
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Carolina Marques Borges, Marina Celly Martins Ribeiro de Souza, Ana Cristina Viana Campos, and Tuula Oksanen
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social capital ,aging ,social determinants of health ,Nursing ,RT1-120 ,Geriatrics ,RC952-954.6 ,Public aspects of medicine ,RA1-1270 - Abstract
OBJECTIVE: This study sought to investigate the association between social capital and the use of health services among Brazilian non-institutionalized older adults living in an urban metropolitan area. METHODS: The sample was comprised of 2,052 respondents aged 60 or older. Individual Social Capital was measured by The World Bank Integrated Questionnaire (IQ-MSC) dichotomized in “low” and “high” social Capital. Use of health services, community engagement, familiar functionality, and social demographics were assessed. RESULTS: Individuals who belonged to the low social capital group were 73% more likely to have a medical appointment in the 6 months previous to the interview [OR = 1.76; 95%CI 1.19–2.52] compared to the high social capital group. In the opposite direction, individuals who belonged to the low social capital group were 29% less likely to have a dental appointment regularly [OR = 0.71; 95%CI 0.51–0.98], were 88% less likely to be engaged in community projects [OR = 0.12; 95%CI 0.09–0.15], and 42% less likely to have a good familiar functionality [OR = 0.58; 95%CI 0.37–0.88], compared to the older adults who had high levels of social capital. Conclusion: Individual low social capital affected the pattern that older adults used health services in the investigated population differently.
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- 2024
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21. Does job stress mediate the risk of work disability due to common mental disorders among social workers compared with other health and social care, education, and non-human service professionals? A prospective cohort study of public sector employees in Finland
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Otso Rantonen, Jenni Ervasti, Kristina Alexanderson, Tuula Oksanen, Ville Aalto, Ellenor Mittendorfer-Rutz, and Paula Salo
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stress ,sick leave ,job strain ,job stress ,education ,sickness absence ,prospective cohort study ,finland ,work disability ,mental disorder ,social worker ,public sector employee ,effort-reward imbalance ,social care ,non-human service professional ,human service profession ,counterfactual mediation analysis ,Public aspects of medicine ,RA1-1270 - Abstract
OBJECTIVE: This study aimed to investigate (i) the risk of work disability (>10-day sickness absence spell or disability pension) due to common mental disorders (CMD) among social workers compared with other health and social care, education, and non-human service professionals and (ii) whether the risk was mediated by job stress. METHODS: A cohort of 16 306 public sector professionals in Finland was followed using survey data from baseline (2004 or if not available, 2008) on job stress [job strain or effort-reward imbalance (ERI)] and register data on work disability due to CMD from baseline through 2011. A Cox proportional hazards model was used to analyze the risk of work disability due to CMD between three occupation-pairs in a counterfactual setting, controlling for age, sex, job contract, body mass index, alcohol risk use, smoking, and physical inactivity. RESULTS: Social workers’ job stress was at higher level only when compared to education professionals. Thus, the mediation hypothesis was analyzed comparing social workers to education professionals. Social workers had a higher risk of work disability due to CMD compared with education professionals [hazard ratio (HR) 2.08, 95% confidence interval (CI) 1.58–2.74]. This HR was partly mediated by job strain (24%) and ERI (12%). Social workers had a higher risk of work disability than non-human service professionals (HR 1.54, 95% CI 1.13–2.09), but not compared with other health and social care professionals. CONCLUSIONS: Job stress partly mediated the excess risk of work disability among social workers only in comparison with education professionals.
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- 2024
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22. A Surprising Periodicity Detected During a Super-outburst of V844 Herculis by TESS
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Greiveldinger, A., Garnavich, P., Littlefield, C., Kennedy, M. R., Halpern, J. P., Thorstensen, J. R., Szkody, P., Oksanen, A., and Boyle, R. S.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We identify a previously undetected periodicity at a frequency of 49.08$\pm$0.01 d$^{-1}$ (period of 29.34$\pm$0.01 minutes) during a super-outburst of V844 Her observed by TESS. V844 Her is an SU UMa type cataclysmic variable with an orbital period of 78.69 minutes, near the period minimum. The frequency of this new signal is constant in contrast to the superhump oscillations commonly seen in SU UMa outbursts. We searched without success for oscillations during quiescence using MDM, TESS, and XMM-Newton data. The lack of a periodic signal in the XMM light curve and the relatively low X-ray luminosity of V844 Her suggests that it is not a typical IP. We consider the possibility that the 29 min signal is the result of super-Nyquist sampling of a Dwarf Nova Oscillation with a period near the 2-minute cadence of the TESS data. Our analysis of archival AAVSO photometry from a 2006 super-outburst supports the existence of a 29 min oscillation, although a published study of an earlier superoutburst did not detect the signal. We compare the X-ray properties of V844 Her with short orbital period intermediate polars (IP), V1025 Cen and DW Cnc. We conclude that the new signal is a real photometric oscillation coming from the V844 Her system and that it is unlikely to be an aliased high-frequency oscillation. The steady frequency of the new signal suggests that its origin is related to an asynchronously rotating white dwarf in V844 Her, although the precise mechanism producing the flux variations remains unclear., Comment: 13 pages, 10 figures, accepted for publication in the Astrophysical Journal
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- 2023
23. RB-Dust -- A Reference-based Dataset for Vision-based Dust Removal
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Buckel, Peter, Oksanen, Timo, and Dietmueller, Thomas
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Dust in the agricultural landscape is a significant challenge and influences, for example, the environmental perception of autonomous agricultural machines. Image enhancement algorithms can be used to reduce dust. However, these require dusty and dust-free images of the same environment for validation. In fact, to date, there is no dataset that we are aware of that addresses this issue. Therefore, we present the agriscapes RB-Dust dataset, which is named after its purpose of reference-based dust removal. It is not possible to take pictures from the cabin during tillage, as this would cause shifts in the images. Because of this, we built a setup from which it is possible to take images from a stationary position close to the passing tractor. The test setup was based on a half-sided gate through which the tractor could drive. The field tests were carried out on a farm in Bavaria, Germany, during tillage. During the field tests, other parameters such as soil moisture and wind speed were controlled, as these significantly affect dust development. We validated our dataset with contrast enhancement and image dehazing algorithms and analyzed the generalizability from recordings from the moving tractor. Finally, we demonstrate the application of dust removal based on a high-level vision task, such as person classification. Our empirical study confirms the validity of RB-Dust for vision-based dust removal in agriculture., Comment: Accepted by CVPR Workshop NTIRE 2023. Errata: Caption Figure 6 changed
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- 2023
24. Rigidity of inverse problems for nonlinear elliptic equations on manifolds
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Feizmohammadi, Ali, Kian, Yavar, and Oksanen, Lauri
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Mathematics - Analysis of PDEs ,35R30, 35J91 - Abstract
We consider the inverse problem of determining coefficients appearing in semilinear elliptic equations stated on Riemannian manifolds with boundary given the knowledge of the associated Dirichlet-to-Neumann map. We begin with a negative answer to this problem. Owing to this obstruction, we consider a new formulation of our inverse problem in terms of a rigidity problem. Precisely, we consider cases where the Dirichlet-to-Neumann map of a semilinear equation coincides with the one of a linear equation and ask whether this implies that the equation must indeed be linear. We give a positive answer to this rigidity problem under some assumptions imposed to the Riemannian manifold and to the semilinear term under consideration.
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- 2023
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25. Quantum computing algorithms for inverse problems on graphs and an NP-complete inverse problem
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Ilmavirta, Joonas, Lassas, Matti, Lu, Jinpeng, Oksanen, Lauri, and Ylinen, Lauri
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Mathematics - Combinatorics ,Computer Science - Computational Complexity ,Quantum Physics ,52C25 (Primary) 68Q12, 68Q17 (Secondary) - Abstract
We consider an inverse problem for a finite graph $(X,E)$ where we are given a subset of vertices $B\subset X$ and the distances $d_{(X,E)}(b_1,b_2)$ of all vertices $b_1,b_2\in B$. The distance of points $x_1,x_2\in X$ is defined as the minimal number of edges needed to connect two vertices, so all edges have length 1. The inverse problem is a discrete version of the boundary rigidity problem in Riemannian geometry or the inverse travel time problem in geophysics. We will show that this problem has unique solution under certain conditions and develop quantum computing methods to solve it. We prove the following uniqueness result: when $(X,E)$ is a tree and $B$ is the set of leaves of the tree, the graph $(X,E)$ can be uniquely determined in the class of all graphs having a fixed number of vertices. We present a quantum computing algorithm which produces a graph $(X,E)$, or one of those, which has a given number of vertices and the required distances between vertices in $B$. To this end we develop an algorithm that takes in a qubit representation of a graph and combine it with Grover's search algorithm. The algorithm can be implemented using only $O(|X|^2)$ qubits, the same order as the number of elements in the adjacency matrix of $(X,E)$. It also has a quadratic improvement in computational cost compared to standard classical algorithms. Finally, we consider applications in theory of computation, and show that a slight modification of the above inverse problem is NP-complete: all NP-problems can be reduced to a discrete inverse problem we consider., Comment: 42 pages, 3 figures; added numerical examples (appendix A)
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- 2023
26. Online communities come with real-world consequences for individuals and societies
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Oksanen, Atte, Celuch, Magdalena, Oksa, Reetta, and Savolainen, Iina
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- 2024
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27. Optimal Approximation of Unique Continuation
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Burman, Erik, Nechita, Mihai, and Oksanen, Lauri
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- 2024
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28. The circular economy of electric vehicle batteries: a Finnish case study
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Rönkkö, Pasi, Majava, Jukka, Hyvärinen, Tatu, Oksanen, Ilari, Tervonen, Pekka, and Lassi, Ulla
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- 2024
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29. Pathways to School Shooting Subculture: Re-thinking Theory Across Strain, Imitation, and Digital Mediation
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Mizrahi-Werner, Jonatan, Diederichsen, Martine Bech, Ilsøe, Benjamin Schou, Demant, Jakob, and Oksanen, Atte
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- 2024
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30. Finite element approximation of unique continuation of functions with finite dimensional trace
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Burman, Erik and Oksanen, Lauri
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Mathematics - Numerical Analysis ,65N21, 35J15, 65N12, 65N20, 65N30 - Abstract
We consider a unique continuation problem where the Dirichlet trace of the solution is known to have finite dimension. We prove Lipschitz stability of the unique continuation problem and design a finite element method that exploits the finite dimensionality to enhance stability. Optimal a priori and a posteriori error estimates are shown for the method. The extension to problems where the trace is not in a finite dimensional space, but can be approximated to high accuracy using finite dimensional functions is discussed. Finally, the theory is illustrated in some numerical examples.
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- 2023
31. Disjoint data inverse problem on manifolds with quantum chaos bounds
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Lassas, Matti, Nursultanov, Medet, Oksanen, Lauri, and Ylinen, Lauri
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Mathematics - Analysis of PDEs - Abstract
We consider the inverse problem to determine a smooth compact Riemannian manifold $(M,g)$ from a restriction of the source-to-solution operator, $\Lambda_{\mathcal{S,R}}$, for the wave equation on the manifold. Here, $\mathcal{S}$ and $\mathcal{R}$ are open sets on $M$, and $\Lambda_{\mathcal{S,R}}$ represents the measurements of waves produced by smooth sources supported on $\mathcal{S}$ and observed on $\mathcal{R}$. We emphasise that $\overline{\mathcal{S}}$ and $\overline{\mathcal{R}}$ could be disjoint. We demonstrate that $\Lambda_{\mathcal{S,R}}$ determines the manifold $(M,g)$ uniquely under the following spectral bound condition for the set $\mathcal{S}$: There exists a constant $C>0$ such that any normalized eigenfunction $\phi_k$ of the Laplace-Beltrami operator on $(M,g)$ satisfies \begin{equation*} 1\leq C\|\phi_k\|_{L^2(\mathcal{S})}. \end{equation*} We note that, for the Anosov surface, this spectral bound condition is fulfilled for any non-empty open subset $\mathcal{S}$. Our approach is based on the paper [18] and the spectral bound condition above is an analogue of the Hassell-Tao condition there., Comment: 16 pages
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- 2023
32. Online communities come with real-world consequences for individuals and societies
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Atte Oksanen, Magdalena Celuch, Reetta Oksa, and Iina Savolainen
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Psychology ,BF1-990 ,Social Sciences - Abstract
Abstract Online communities have become a central part of the internet. Understanding what motivates users to join these communities, and how they affect them and others, spans various psychological domains, including organizational psychology, political and social psychology, and clinical and health psychology. We focus on online communities that are exemplary for three domains: work, hate, and addictions. We review the risks that emerge from these online communities but also recognize the opportunities that work and behavioral addiction communities present for groups and individuals. With the continued evolution of online spheres, online communities are likely to have an increasingly significant role in all spheres of life, ranging from personal to professional and from individual to societal. Psychological research provides critical insights into understanding the formation of online communities, and the implications for individuals and society. To counteract risks, it needs to identify opportunities for prevention and support.
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- 2024
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33. Treatment sequencing and impact of number of treatment lines on survival in follicular lymphoma: A national population‐based study
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Tove Wästerlid, Caroline E. Dietrich, Anna Oksanen, Linn Deleskog Spångberg, Björn E Wahlin, Gunilla Enblad, Per‐Ola Andersson, Eva Kimby, and Karin E. Smedby
- Subjects
follicular lymphoma ,POD24 ,population‐based ,treatment sequencing ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Abstract Follicular lymphoma (FL) is a clinically heterogeneous disease. The need for treatment, treatment sequencing, number of treatment lines, and its association with survival have not been described in a population‐based setting. We identified all patients diagnosed with FL in the Swedish Lymphoma register from 2007 to 2014, followed until 2020, with detailed data on progression/relapse, transformation, and 2nd and further lines of therapy. During a median follow‐up of 6.8 years, 1226 patients (69%) received 1st systemic treatment, 358 patients (20%) were managed with watch‐and‐wait (WaW) only, and 188 (10%) patients were treated with radiotherapy and did not require additional therapy during the study period. Among patients starting systemic treatment, 496 (40%), 224 (18%), and 88 (7%) received 2nd‐, 3rd‐, or 4th‐line therapy, respectively. The 10‐year cause‐specific cumulative incidence of transformation was 13%. Among patients managed with 1st line R‐single, R‐CHOP, or BR, 54%, 33%, and 29% required 2nd line, respectively. The cumulative probability of starting subsequent treatment within 2 years was 26% after 1st line and 35% after 2nd line treatment. Two‐year OS following 1st, 2nd, 3rd, and 4th line systemic treatment was 84%, 70%, 52%, and 36%, respectively, and remained similar when excluding transformations. We conclude that a substantial proportion of FL patients can be managed with WaW for a long period of time, while patients who require multiple treatment lines constitute a group with a large clinical unmet need. These results constitute valuable real‐world reference data for FL.
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- 2024
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34. Stable Recovery of Coefficients in an Inverse Fault Friction Problem
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de Hoop, Maarten V., Lassas, Matti, Lu, Jinpeng, and Oksanen, Lauri
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- 2024
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35. Teachers’ entrepreneurship education practices: international comparison
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Oksanen, Lea, primary
- Published
- 2024
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36. Reflecting on the potential of EntreCompEdu to stimulate teachers’ entrepreneurial thinking and activity
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Grigg, Russell, primary, Healey-Benson, Felicity, additional, Israel, Hazel, additional, McCallum, Elin, additional, and Oksanen, Lea, additional
- Published
- 2024
- Full Text
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37. Broad Adaptability of Coronavirus Adhesion Revealed from the Complementary Surface Affinity of Membrane and Spikes
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Aritz B. García‐Arribas, Pablo Ibáñez‐Freire, Diego Carlero, Pablo Palacios‐Alonso, Miguel Cantero‐Reviejo, Pablo Ares, Guillermo López‐Polín, Han Yan, Yan Wang, Soumya Sarkar, Manish Chhowalla, Hanna M. Oksanen, Jaime Martín‐Benito, Pedro J. de Pablo, and Rafael Delgado‐Buscalioni
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atomic‐force‐microscopy ,coarse‐graining models ,coronavirus ,elastic theory ,surface‐affinity ,Science - Abstract
Abstract Coronavirus stands for a large family of viruses characterized by protruding spikes surrounding a lipidic membrane adorned with proteins. The present study explores the adhesion of transmissible gastroenteritis coronavirus (TGEV) particles on a variety of reference solid surfaces that emulate typical virus‐surface interactions. Atomic force microscopy informs about trapping effectivity and the shape of the virus envelope on each surface, revealing that the deformation of TGEV particles spans from 20% to 50% in diameter. Given this large deformation range, experimental Langmuir isotherms convey an unexpectedly moderate variation in the adsorption‐free energy, indicating a viral adhesion adaptability which goes beyond the membrane. The combination of an extended Helfrich theory and coarse‐grained simulations reveals that, in fact, the envelope and the spikes present complementary adsorption affinities. While strong membrane‐surface interaction lead to highly deformed TGEV particles, surfaces with strong spike attraction yield smaller deformations with similar or even larger adsorption‐free energies.
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- 2024
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38. Craniofacial fractures sustained under the influence of alcohol: what are the differences between the sexes?
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Hanna Thorén, Klaus Virtanen, Erkka Oksanen, Miika Toivari, Auli Suominen, Tero Puolakkainen, and Johanna Snäll
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Facial fracture ,trauma ,alcohol ,intoxication ,Dentistry ,RK1-715 - Abstract
Objective: To identify mechanisms and types of injuries in patients having sustained craniofacial fractures under the influence of alcohol, and to compare the frequencies of them between males and females. Materials and methods: Patients included were adults who had been diagnosed with craniofacial fractures at Töölö Hospital Emergency Department, Helsinki University Hospital, Finland, and who had been under the influence of alcohol at the time of injury. The primary outcome variables were assault-related and fall-related injury mechanisms. The secondary outcome variables were other injury mechanisms, time of accident, type of craniofacial fracture and severity of facial fracture. The primary predictor variable was sex. The control variable was age at the time of injury. The statistical modelling was executed using logistic regression. Results: Of the total of 2,859 patients with craniofacial fractures, 1,014 patients (35.5%) fulfilled the inclusion criteria. Males predominated (84.6%). Assault (38.0%) was the most frequent aetiology. Compared to the odds of females, males had 2.8 times greater odds for assault, 2.4 times greater odds for isolated cranial fracture and 1.7 times greater odds for a facial injury severity score of ≥ 3. Females had 2.0 times greater odds for any fall compared to the odds of males. Conclusions: Particularly male patients are frequently under the influence of alcohol at the time of injury, predisposing them to assault and severe facial fractures more often than females. Codes of practice on how to identify unhealthy alcohol use and how to intervene are recommended.
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- 2024
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39. Bridging the Integrity Gap: Towards AI-assisted Design Research.
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Joel Oksanen
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- 2024
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40. Sociodemographic differences and experienced effects of young adults who use cannabis mainly for self-medication versus recreationally in Finland
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Hupli, Aleksi, Unlu, Ali, Jylkkä, Jussi, and Oksanen, Atte
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- 2024
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41. Lymphatic dwelling filarioid nematodes in reindeer Rangifer tarandus tarandus, (Cervidae) in Finland, identified as Rumenfilaria andersoni Lankester & Snider, 1982 (Nematoda: Onchocercidae: Splendidofilariinae)
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Laaksonen S., Saari S., Nikander S., Oksanen A., and Bain O.
- Subjects
filarioid ,lymphatic filariosis ,Rumenfilaria ,Rangifer tarandus ,Alces alces ,Infectious and parasitic diseases ,RC109-216 - Abstract
A filarioid nematode inhabiting the lymphatic vessels of the subserosal rumen and mesenteries associated with a high prevalence of its microfilariae in peripheral blood was observed in Finnish reindeer (Rangifer tarandus tarandus) in 2004 and 2006. Adult specimens were collected by dissecting lymphatic vessels from slaughtered animals, where some of the nematodes were seen through the wall of the dilated vessels as thin white winding threads obscuring the vessel. The morphology of adult worms and microfilaria is described based on light and scanning electron microscopy. These filariae belong to the subfamily Splendidofilariinae of the Onchocercidae and resemble Rumenfilaria andersoni, recovered from different host and localization, the ruminal veins of Alces alces in Canada. Comparison of paratypes of this species revealed only minor differences which were not sufficient to separate the filarioid parasitic in R. tarandus in Finland and we identify the nematode as R. andersoni. However, the findings suggest two different parasite populations. The finalizing of this taxonomic question in the future requires an integrated approach, in which the DNAbased and morphological identifications are consistent.
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- 2010
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42. Demonstration of Gd-GEM detector design for neutron macromolecular crystallography applications
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Pfeiffer, D., Brunbauer, F., Hall-Wilton, R., Lupberger, M., Marko, M., Muller, H., Oksanen, E., Oliveri, E., Ropelewski, L., Rusu, A., Samarati, J., Scharenberg, L., van Stenis, M., Thuiner, P., and Veenhof, R.
- Subjects
Physics - Instrumentation and Detectors - Abstract
The European Spallation Source (ESS) in Lund, Sweden will become the world's most powerful thermal neutron source. The Macromolecular Diffractometer (NMX) at the ESS requires three 51.2 x 51.2~cm$^{2}$ detectors with reasonable detection efficiency, sub-mm spatial resolution, a narrow point spread function (PSF) and good time resolution. This work presents measurements with the improved version of the NMX detector prototype consisting of a Triple-GEM detector with natural Gd converter and a low material budget readout. The detector was successfully tested at the neutron reactor of the Budapest Neutron Centre (BNC) and at the D16 instrument at the Institut Laue-Langevin (ILL) in Grenoble. The measurements with Cadmium and Gadolinium masks in Budapest demonstrate that the point spread function of the detector lacks long tails that could impede the measurement of diffraction spot intensities. On the D16 instrument at ILL, diffraction spots from Triose phosphate isomerase w/ 2-phosphoglycolate (PGA) inhibitor were measured both in the D16 Helium-3 detector and the Gd-GEM. The comparison between the two detectors show a similar point spread function in both detectors, and the expected efficiency ratio compared to the Helium-3 detector. Both measurements together thus give good indications that the Gd-GEM detector fits the requirements for the NMX instrument at ESS.
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- 2022
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- View/download PDF
43. Alternative approach to the Starobinsky model for inflation scenarios
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Chaichian, Masud, Ghal'e, Amir, and Oksanen, Markku
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
The $R+R^2$ model of gravity with the corresponding shallow potential in the Einstein frame is consistent with the observations. Recently, many efforts have been made to generalize the $R+R^2$ (Starobinsky) model of inflation or use other shallow potentials to construct a model for the early Universe. We revise the question about the shallow potential. We propose a model in which the Starobinsky model can emerge through a dynamical mechanism. We show that the absence of ghost modes results to constraints on the parameters of the Starobinsky model. We obtain the scalar spectral index and the tensor-to-scalar ratio of the extended model and study the three-point correlation function of the curvature perturbation to estimate the primordial non-Gaussianities of the proposed model., Comment: 24 pages, 4 figures. v4: corrections to language and references; added affiliation; to appear in Phys. Rev. D. arXiv admin note: substantial text overlap with arXiv:2012.10889
- Published
- 2022
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44. V392 Persei: a \gamma-ray bright nova eruption from a known dwarf nova
- Author
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Murphy-Glaysher, F. J., Darnley, M. J., Harvey, É. J., Newsam, A. M., Page, K. L., Starrfield, S., Wagner, R. M., Woodward, C. E., Terndrup, D. M., Kafka, S., Heras, T. Arranz, Berardi, P., Bertrand, E., Biernikowicz, R., Boussin, C., Boyd, D., Buchet, Y., Bundas, M., Coulter, D., Dejean, D., Diepvens, A., Dvorak, S., Edlin, J., Eenmae, T., Eggenstein, H., Fournier, R., Garde, O., Gout, J., Janzen, D., Jordanov, P., Kiiskinen, H., Lane, D., Larochelle, R., Leadbeater, R., Mankel, D., Martineau, G., Miller, I., Modic, R., Montier, J., Aimar, M. Morales, Muyllaert, E., Nogues, R. Naves, O'Keeffe, D., Oksanen, A., Pyatnytskyy, M., Rast, R., Rodgers, B., Perez, D. Rodriguez, Schorr, F., Schwendeman, E., Shadick, S., Sharpe, S., Alfaro, F. Soldán, Sove, T., Stone, G., Tordai, T., Venne, R., Vollmann, W., Vrastak, M., and Wenzel, K.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
V392 Persei is a known dwarf nova (DN) that underwent a classical nova eruption in 2018. Here we report ground-based optical, Swift UV and X-ray, and Fermi-LAT \gamma-ray observations following the eruption for almost three years. V392 Per is one of the fastest evolving novae yet observed, with a $t_2$ decline time of 2 days. Early spectra present evidence for multiple and interacting mass ejections, with the associated shocks driving both the \gamma-ray and early optical luminosity. V392 Per entered Sun-constraint within days of eruption. Upon exit, the nova had evolved to the nebular phase, and we saw the tail of the super-soft X-ray phase. Subsequent optical emission captured the fading ejecta alongside a persistent narrow line emission spectrum from the accretion disk. Ongoing hard X-ray emission is characteristic of a standing accretion shock in an intermediate polar. Analysis of the optical data reveals an orbital period of 3.230 \pm 0.003 days, but we see no evidence for a white dwarf (WD) spin period. The optical and X-ray data suggest a high mass WD, the pre-nova spectral energy distribution (SED) indicates an evolved donor, and the post-nova SED points to a high mass accretion rate. Following eruption, the system has remained in a nova-like high mass transfer state, rather than returning to the pre-nova DN low mass transfer configuration. We suggest that this high state is driven by irradiation of the donor by the nova eruption. In many ways, V392 Per shows similarity to the well-studied nova and DN GK Persei., Comment: Accepted by MNRAS. 20 pages including references, with 37 pages of supplementary material
- Published
- 2022
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45. Four principles to establish a universal virus taxonomy
- Author
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Simmonds, Peter, Adriaenssens, Evelien M, Zerbini, F Murilo, Abrescia, Nicola GA, Aiewsakun, Pakorn, Alfenas-Zerbini, Poliane, Bao, Yiming, Barylski, Jakub, Drosten, Christian, Duffy, Siobain, Duprex, W Paul, Dutilh, Bas E, Elena, Santiago F, García, Maria Laura, Junglen, Sandra, Katzourakis, Aris, Koonin, Eugene V, Krupovic, Mart, Kuhn, Jens H, Lambert, Amy J, Lefkowitz, Elliot J, Łobocka, Małgorzata, Lood, Cédric, Mahony, Jennifer, Meier-Kolthoff, Jan P, Mushegian, Arcady R, Oksanen, Hanna M, Poranen, Minna M, Reyes-Muñoz, Alejandro, Robertson, David L, Roux, Simon, Rubino, Luisa, Sabanadzovic, Sead, Siddell, Stuart, Skern, Tim, Smith, Donald B, Sullivan, Matthew B, Suzuki, Nobuhiro, Turner, Dann, Van Doorslaer, Koenraad, Vandamme, Anne-Mieke, Varsani, Arvind, and Vasilakis, Nikos
- Subjects
Infectious Diseases ,Infection ,Humans ,Bacteriophages ,Metagenomics ,Phylogeny ,Viruses ,Biological Sciences ,Agricultural and Veterinary Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
A universal taxonomy of viruses is essential for a comprehensive view of the virus world and for communicating the complicated evolutionary relationships among viruses. However, there are major differences in the conceptualisation and approaches to virus classification and nomenclature among virologists, clinicians, agronomists, and other interested parties. Here, we provide recommendations to guide the construction of a coherent and comprehensive virus taxonomy, based on expert scientific consensus. Firstly, assignments of viruses should be congruent with the best attainable reconstruction of their evolutionary histories, i.e., taxa should be monophyletic. This fundamental principle for classification of viruses is currently included in the International Committee on Taxonomy of Viruses (ICTV) code only for the rank of species. Secondly, phenotypic and ecological properties of viruses may inform, but not override, evolutionary relatedness in the placement of ranks. Thirdly, alternative classifications that consider phenotypic attributes, such as being vector-borne (e.g., "arboviruses"), infecting a certain type of host (e.g., "mycoviruses," "bacteriophages") or displaying specific pathogenicity (e.g., "human immunodeficiency viruses"), may serve important clinical and regulatory purposes but often create polyphyletic categories that do not reflect evolutionary relationships. Nevertheless, such classifications ought to be maintained if they serve the needs of specific communities or play a practical clinical or regulatory role. However, they should not be considered or called taxonomies. Finally, while an evolution-based framework enables viruses discovered by metagenomics to be incorporated into the ICTV taxonomy, there are essential requirements for quality control of the sequence data used for these assignments. Combined, these four principles will enable future development and expansion of virus taxonomy as the true evolutionary diversity of viruses becomes apparent.
- Published
- 2023
46. Tekoälyasenteet ja psykologiset perustarpeet
- Author
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Bergdahl, Jenna, primary, Savolainen, Iina, additional, and Oksanen, Atte, additional
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- 2024
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47. From wildlife to humans: The global distribution of Trichinella species and genotypes in wildlife and wildlife-associated human trichinellosis
- Author
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Cody J. Malone, Antti Oksanen, Samson Mukaratirwa, Rajnish Sharma, and Emily Jenkins
- Subjects
Epidemiology ,Foodborne disease ,Trichinella ,Trichinellosis ,Zoonotic disease ,Zoology ,QL1-991 - Abstract
Zoonotic nematodes of the genus Trichinella are foodborne parasites that have a global distribution in wild carnivores and omnivores, with spillover and spillback into domestic livestock and people, with concomitant trade and health consequences. Historically, most human cases were linked to domestic pigs infected with Trichinella spiralis, but under current high biosecurity swine production in many countries, wildlife have become a more important source of human trichinellosis. The aim of this review is to update the global distribution of Trichinella species and genotypes reported in wildlife, as well as reported human outbreaks from the consumption of wildlife. Using several online databases and by “snowballing” references, hundreds of reports of Trichinella spp. in wildlife published between January 1991 and December 2023 provide an important update to the host and geographic range for each of the recognized 13 species/genotypes, grouped by continent. Surveillance effort was highest in Europe and North America, while Africa, Asia, Oceania, Central and South America have had limited surveillance, in some instances with human cases serving as sentinels of transmission in a region. Dozens of human outbreaks are described, with wild boars (Sus scrofa) being the most frequently implicated wildlife species in human outbreaks globally. Bears are an important source of infection in North America, for wildlife tourism, and importation of bear meat has also been implicated in multicountry outbreaks. The largest study limitation was the dearth of molecular identification of larvae in both wildlife surveillance studies and human outbreaks, particulary in under-studied regions. We highlight the need for enhanced molecular epidemiological approaches to outbreaks of this important foodborne parasite, and emphasize the need for a One Health approach to manage Trichinella spp. which transmit among terrestrial and marine wildlife (including migratory birds), pigs, horses, and people, often across large geographic scales and borders.
- Published
- 2024
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48. Tracking Chlamydia – Host interactions and antichlamydial activity in Caenorhabditis elegans
- Author
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Inés Reigada, Karmen Kapp, Theresa Kaudela, María García Soria, Timo Oksanen, and Leena Hanski
- Subjects
Pathogen-host interaction ,Phytomedicine ,Non-genetic antimicrobial resistance ,Schisandra chinensis ,Dibenzocyclooctadiene lignan ,Bacterial persistence ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The fading efficacy of antibiotics is a growing global health concern due to its life-threatening consequences and increased healthcare costs. Non-genetic mechanisms of antimicrobial resistance, such as those employed by Chlamydia pneumoniae and Chlamydia trachomatis, complicate treatment as these bacteria can enter a non-replicative, persistent state under stress, evading antibiotics and linking to inflammatory conditions. Understanding chlamydial persistence at the molecular level is challenging, and new models for studying Chlamydia-host interactions in vivo are urgently needed. Caenorhabditis elegans offers an alternative given its immune system and numerous orthologues of human genes. This study established C. elegans as an in vivo model for chlamydial infection. Both Chlamydia species reduced the worm's lifespan, their DNA being detectable at three- and six-days post-infection. Azithromycin at its MIC (25 nM) failed to prevent the infection-induced lifespan reduction, indicating a persister phenotype. In contrast, the methanolic extract of Schisandra chinensis berries showed anti-chlamydial activity both in vitro (in THP-1 macrophages) and in vivo, significantly extending the lifespan of infected C. elegans and reducing the bacterial load. Moreover, S. chinensis increased the transcriptional activity of SKN-1 in the worms, but was unable to impact the bacterial load or lifespan in a sek-1 defective C. elegans strain. In summary, this study validated C. elegans as a chlamydial infection model and showcased S. chinensis berries' in vivo anti-chlamydial potential, possibly through SEK/SKN-1 signaling modulation.
- Published
- 2024
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49. Many human pharmaceuticals are weak inhibitors of the cytochrome P450 system in rainbow trout (Oncorhynchus mykiss) liver S9 fractions
- Author
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Tea Pihlaja, Timo Oksanen, Netta Vinkvist, and Tiina Sikanen
- Subjects
cytochrome P450 ,enzyme inhibition ,pharmaceuticals ,rainbow trout ,ecotoxicology ,bioaccumulation ,Toxicology. Poisons ,RA1190-1270 - Abstract
IntroductionPharmaceutical residues are widely detected in aquatic environment and can be taken up by nontarget species such as fish. The cytochromes P450 (CYP) represent an important detoxification mechanism in fish, like in humans. In the present study, we assessed the correlation of the substrate selectivities of rainbow trout CYP1A and CYP3A homologues with those of human, through determination of the half-maximal inhibitory concentrations (IC50) of a total sixteen human pharmaceuticals toward CYP1A-like ethoxyresorufin O-deethylase (EROD) and CYP3A-like 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase (BFCOD) in rainbow trout (Oncorhynchus mykiss) liver S9 fractions (RT-S9).MethodsThe inhibitory impacts (IC50) of atomoxetine, atorvastatin, azelastine, bimatoprost, clomethiazole, clozapine, desloratadine, disulfiram, esomeprazole, felbinac, flecainide, orphenadrine, prazosin, quetiapine, sulpiride, and zolmitriptan toward the EROD and BFCOD activities in RT-S9 were determined using the IC50 shift assay, capable of identifying time-dependent inhibitors (TDI). Additionally, the nonspecific binding of the test pharmaceuticals to RT-S9 was assessed using equilibrium dialysis.ResultsMost test pharmaceuticals were moderate to weak inhibitors of both EROD and BFCOD activity in RT-S9, even if most are noninhibitors of human CYP1A or CYP3A. Only bimatoprost, clomethiazole, felbinac, sulpiride, and zolmitriptan did not inhibit either activity in RT-S9. EROD inhibition was generally stronger than that of BFCOD and some substances (atomoxetine, flecainide, and prazosin) inhibited selectively only EROD activity. The strongest EROD inhibition was detected with azelastine and esomeprazole (unbound IC50 of 3.8 ± 0.5 µM and 3.0 ± 0.8 µM, respectively). None of the test substances were TDIs of BFCOD, but esomeprazole was a TDI of EROD. Apart from clomethiazole and disulfiram, the nonspecific binding of the test pharmaceuticals to the RT-S9 was extensive (unbound fractions
- Published
- 2024
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50. Retrieving Yang--Mills--Higgs fields in Minkowski space from active local measurements
- Author
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Chen, Xi, Lassas, Matti, Oksanen, Lauri, and Paternain, Gabriel P.
- Subjects
Mathematics - Analysis of PDEs ,Mathematical Physics ,Mathematics - Differential Geometry - Abstract
We show that we can retrieve a Yang--Mills potential and a Higgs field (up to gauge) from source-to-solution type data associated with the classical Yang--Mills--Higgs equations in Minkowski space $\mathbb{R}^{1+3}$. We impose natural non-degeneracy conditions on the representation for the Higgs field and on the Lie algebra of the structure group which are satisfied for the case of the Standard Model. Our approach exploits the non-linear interaction of waves generated by sources with values in the centre of the Lie algebra showing that abelian components can be used effectively to recover the Higgs field.
- Published
- 2022
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