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121 results on '"Oki, Kentaro"'

1. Factors Contributing to Heat Tolerance in Humans and Experimental Models.

Author

Laitano, Orlando, Oki, Kentaro, and Charkoudian, Nisha

Subjects
*PHYSIOLOGY, *CLIMATE change, *LABORATORY mice, *ANIMAL disease models, *ACCLIMATIZATION
Abstract

Understanding physiological mechanisms of tolerance to heat exposure, and potential ways to improve such tolerance, is increasingly important in the context of ongoing climate change. We discuss the concept of heat tolerance in humans and experimental models (primarily rodents), including intracellular mechanisms and improvements in tolerance with heat acclimation. [ABSTRACT FROM AUTHOR]

Published
2025
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4. Risk-stratified therapy for children with FLT3-ITD-positive acute myeloid leukemia: results from the JPLSG AML-05 study

Author

Shimada, Akira, Iijima-Yamashita, Yuka, Tawa, Akio, Tomizawa, Daisuke, Yamada, Miho, Norio, Shiba, Watanabe, Tomoyuki, Taga, Takashi, Iwamoto, Shotaro, Terui, Kiminori, Moritake, Hiroshi, Kinoshita, Akitoshi, Takahashi, Hiroyuki, Nakayama, Hideki, Koh, Katsuyoshi, Goto, Hiroaki, Kosaka, Yoshiyuki, Saito, Akiko Moriya, Kiyokawa, Nobutaka, Horibe, Keizo, Hara, Yusuke, Oki, Kentaro, Hayashi, Yasuhide, Tanaka, Shiro, and Adachi, Souichi

Published
2018
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9. Partial splenic artery embolization is effective for bleeding gastric varices due to sinistral portal hypertension associated with pancreatic tail cancer

Author

TSUTSUI, Tomoaki, primary, HARADA, Ryo, additional, AKIMOTO, Yutaka, additional, OKI, Kentaro, additional, YOSHIKAWA, Tomoki, additional, YASUI, Toshihiro, additional, AKITA, Mitsuhiro, additional, TOSHIMORI, Junichi, additional, INOUE, Masafumi, additional, and KOBASHI, Haruhiko, additional

Published
2022
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13. Su1421 LONG-TERM PROGNOSIS INCLUDING CANCER DEVELOPMENT IN PATIENTS WITH CHRONIC PANCREATITIS: A MULTICENTER COHORT STUDY IN JAPAN

Author

Matsumoto, Ryotaro, Kikuta, Kazuhiro, Takikawa, Tetsuya, Nakai, Yousuke, Takenaka, Mamoru, Oki, Kentaro, Hirooka, Yoshiki, Ito, Ken, Fujimori, Nao, Katanuma, Akio, Masuda, Atsuhiro, Hori, Yasuki, Ikeura, Tsukasa, Ohira, Hiromasa, Sogame, Yoshio, Kawashima, Hiroki, Ito, Tetsuhide, Okuwaki, Kosuke, Itoi, Takao, Takayama, Yukiko, Umemura, Takeji, Terai, Shuji, Kato, Hironari, Kuwatani, Masaki, Kishiwada, Masashi, Shigekawa, Minoru, Matsumori, Tomoaki, Inatomi, Osamu, Irisawa, Atsushi, Takeyama, Yoshifumi, and Masamune, Atsushi

Published
2024
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16. A Nationwide Clinical Trial ALL-B12: An Optimized Therapy for Pediatric B-Precursor Acute Lymphoblastic Leukemia with Excellent Overall Survival and Minimal Non-Relapse Mortality: A Report from the Japan Children's Cancer Group

Author

Kato, Motohiro, Okamoto, Yasuhiro, Imamura, Toshihiko, Kada, Akiko, Saito, Akiko M, Iijima-Yamashita, Yuka, Deguchi, Takao, Oki, Kentaro, Fukushima, Takashi, Anami, Ken-ichi, Sanada, Masashi, Taki, Tomohiko, Hashii, Yoshiko, Kiyokawa, Nobutaka, Kosaka, Yoshiyuki, Yoshida, NAO, Yuza, Yuki, Yanagimachi, Masakatsu, Watanabe, Kenichiro, Sato, Atsushi, Imai, Chihaya, Taga, Takashi, Adachi, Souichi, Horibe, Keizo, Manabe, Atsushi, and Koh, Katsuyoshi

Published
2023
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20. The Detection of Minor Clones with Somatic KIT D816V Mutations Using Droplet Digital PCR in Pediatric De Novo AML: AML-05 Trial from the Japanese Pediatric Leukemia/Lymphoma Study Group

Author

Sasaki, Koji, primary, Uchiyama, Yuri, additional, Ikeda, Junji, additional, Yoshitomi, Masahiro, additional, Shimosato-Wada, Yuko, additional, Tokumasu, Mayu, additional, Matsuo, Hidemasa, additional, Yoshida, Kenichi, additional, Oki, Kentaro, additional, Yamato, Genki, additional, Hara, Yusuke, additional, Kinoshita, Akitoshi, additional, Tomizawa, Daisuke, additional, Taga, Takashi, additional, Adachi, Souichi, additional, Tawa, Akio, additional, Horibe, Keizo, additional, Matsumoto, Naomichi, additional, Ito, Shuichi, additional, Hayashi, Yasuhide, additional, and Shiba, Norio, additional

Published
2019
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23. Fiber type-specific effects of acute exercise on insulin-stimulated AS160 phosphorylation in insulin-resistant rat skeletal muscle

Author

Pataky, Mark W, Van Acker, Sydney L, Dhingra, Rhea, Freeburg, Marina M, Arias, Edward B, Oki, Kentaro, Wang, Haiyan, Treebak, Jonas T., Cartee, Gregory D, Pataky, Mark W, Van Acker, Sydney L, Dhingra, Rhea, Freeburg, Marina M, Arias, Edward B, Oki, Kentaro, Wang, Haiyan, Treebak, Jonas T., and Cartee, Gregory D

Abstract

Muscle is a heterogeneous tissue composed of multiple fiber types. Earlier research revealed fiber type-selective postexercise effects on insulin-stimulated glucose uptake (ISGU) from insulin-resistant rats (increased for type IIA, IIB, IIBX, and IIX, but not type I). In whole muscle from insulin-resistant rats, the exercise increase in ISGU is accompanied by an exercise increase in insulin-stimulated AS160 phosphorylation (pAS160), an ISGU-regulating protein. We hypothesized that, in insulin-resistant muscle, the fiber type-selective exercise effects on ISGU would correspond to the fiber type-selective exercise effects on pAS160. Rats were fed a 2-wk high-fat diet (HFD) and remained sedentary (SED) or exercised before epitrochlearis muscles were dissected either immediately postexercise (IPEX) or at 3 h postexercise (3hPEX) using an exercise protocol that previously revealed fiber type-selective effects on ISGU. 3hPEX muscles and SED controls were incubated ± 100µU/mL insulin. Individual myofibers were isolated and pooled on the basis of myosin heavy chain (MHC) expression, and key phosphoproteins were measured. Myofiber glycogen and MHC expression were evaluated in muscles from other SED, IPEX, and 3hPEX rats. Insulin-stimulated pAktSer473 and pAktThr308 were unaltered by exercise in all fiber types. Insulin-stimulated pAS160 was greater for 3hPEX vs. SED on at least one phosphosite (Ser588, Thr642, and/or Ser704) in type IIA, IIBX, and IIB fibers, but not in type I or IIX fibers. Both IPEX and 3hPEX glycogen were decreased versus SED in all fiber types. These results provided evidence that fiber type-specific pAS160 in insulin-resistant muscle may play a role in the previously reported fiber type-specific elevation in ISGU in some, but not all, fiber types.

Published
2019

26. B-lymphoblastic lymphoma with TCF3-PBX1 fusion gene

Author

Kubota-Tanaka, Mari, primary, Osumi, Tomoo, additional, Miura, Shouko, additional, Tsujimoto, Hiroshi, additional, Imamura, Toshihiko, additional, Nishimura, Akira, additional, Oki, Kentaro, additional, Nakamura, Kozue, additional, Miyamoto, Satoshi, additional, Inoue, Kento, additional, Inoue, Maiko, additional, Kamiya, Takahiro, additional, Yanagimachi, Masakatsu, additional, Okano, Tsubasa, additional, Mitsuiki, Noriko, additional, Isoda, Takeshi, additional, Imai, Kohsuke, additional, Kanegane, Hirokazu, additional, Morio, Tomohiro, additional, Kounami, Shinji, additional, Endo, Mikiya, additional, Kato, Motohiro, additional, and Takagi, Masatoshi, additional

Published
2018
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29. Effects of Acute Exercise Combined With Calorie Restriction Initiated Late-in-Life on Insulin Signaling, Lipids, and Glucose Uptake in Skeletal Muscle From Old Rats.

Author

Oki, Kentaro, Arias, Edward B, Kanzaki, Makoto, and Cartee, Gregory D

Subjects
*LOW-calorie diet, *SKELETAL muscle, *LIPIDS, *INSULIN, *EXERCISE
Abstract

We evaluated effects of calorie restriction (CR: consuming 60–65% of ad libitum [AL] intake) initiated late-in-life with or without acute exercise on insulin-stimulated glucose uptake (ISGU) of skeletal muscle by studying four groups of 26-month-old rats: sedentary-AL, sedentary-CR (8-week duration), 3 hours post-exercise (3hPEX)-AL and 3hPEX-CR. ISGU was determined in isolated epitrochlearis muscles incubated ± insulin. Muscles were assessed for signaling proteins (immunoblotting) and lipids (mass spectrometry). ISGU from sedentary-CR and 3hPEX-AL exceeded sedentary-AL; 3hPEX-CR exceeded all other groups. Akt (Ser473, Thr308) and Akt substrate of 160 kDa (AS160; Ser588, Thr642, Ser704) phosphorylation levels tracked with ISGU. Among the 477 lipids detected, 114 were altered by CR (including reductions in 15 of 25 acylcarnitines), and 27 were altered by exercise (including reductions in 18 of 22 lysophosphatidylcholines) with only six lipids overlapping between CR and exercise. ISGU significantly correlated with 23 lipids, including: acylcarnitine 20:1 (r =.683), lysophosphatidylethanolamine19:0 (r = −.662), acylcarnitine 24:0 (r =.611), and plasmenyl-phosphatidylethanolamine 37:5 (r = −.603). Muscle levels of ceramides (a lipid class previously linked to insulin resistance) were not altered by CR and/or exercise nor significantly correlated with ISGU, implicating other mechanisms (which potentially involve other lipids identified in this study) for greater ISGU and Akt and AS160 phosphorylation with these interventions. [ABSTRACT FROM AUTHOR]

Published
2020
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30. Identifications of Highly Aggressive Phenotype with SPI1 Overexpression in Pediatric T Cell Acute Lymphoblastic Leukemia/Lymphoma

Author

Seki, Masafumi, primary, Kimura, Shunsuke, additional, Yoshida, Kenichi, additional, Isobe, Tomoya, additional, Ueno, Hiroo, additional, Suzuki, Hiromichi, additional, Shiozawa, Yusuke, additional, Kataoka, Keisuke, additional, Fujii, Yoichi, additional, Shiraishi, Yuichi, additional, Chiba, Kenichi, additional, Tanaka, Hiroko, additional, Takagi, Masatoshi, additional, Iwama, Atsushi, additional, Oki, Kentaro, additional, Kato, Motohiro, additional, Koh, Katsuyoshi, additional, Hanada, Ryoji, additional, Moritake, Hiroshi, additional, Kobayashi, Ryoji, additional, Deguchi, Takao, additional, Hashii, Yoshiko, additional, Imamura, Toshihiko, additional, Sato, Atsushi, additional, Horibe, Keizo, additional, Kiyokawa, Nobutaka, additional, Manabe, Atsushi, additional, Ohara, Akira, additional, Sanada, Masashi, additional, Hayashi, Yasuhide, additional, Mano, Hiroyuki, additional, Miyano, Satoru, additional, Oka, Akira, additional, Ogawa, Seishi, additional, and Takita, Junko, additional

Published
2016
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33. Detection of Novel Pathogenic Gene Rearrangements in Pediatric Acute Myeloid Leukemia By RNA Sequencing

Author

Shiba, Norio, primary, Yoshida, Kenichi, additional, Shiraishi, Yuichi, additional, Hara, Yusuke, additional, Yamato, Genki, additional, Kaburaki, Taeko, additional, Sanada, Masashi, additional, Oki, Kentaro, additional, Tomizawa, Daisuke, additional, Sotomatsu, Manabu, additional, Arakawa, Hirokazu, additional, Horibe, Keizo, additional, PARK, Myoung-Ja, additional, Taga, Takashi, additional, Adachi, Souichi, additional, Tawa, Akio, additional, Miyano, Satoru, additional, Ogawa, Seishi, additional, and Hayashi, Yasuhide, additional

Published
2015
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35. Contractile dysfunction in muscle may underlie androgen-dependent motor dysfunction in spinal bulbar muscular atrophy

Author

Oki, Kentaro, primary, Halievski, Katherine, additional, Vicente, Laura, additional, Xu, Youfen, additional, Zeolla, Donald, additional, Poort, Jessica, additional, Katsuno, Masahisa, additional, Adachi, Hiroaki, additional, Sobue, Gen, additional, Wiseman, Robert W., additional, Breedlove, S. Marc, additional, and Jordan, Cynthia L., additional

Published
2015
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36. RARB Translocations in Acute Promyelocytic Leukemia without Rara translocation

Author

Kato, Motohiro, Osumi, Tomoo, Tsujimoto, Shinichi, Tamura, Moe, Uchiyama, Meri, Nakabayashi, Kazuhiko, Okamura, Kohji, Tomizawa, Daisuke, Watanabe, Akihiro, Takahashi, Hiroyuki, Hori, Tsukasa, Yamamoto, Shohei, Hamamoto, Kazuko, Migita, Masahiro, Ogata-Kawata, Hiroko, Uchiyama, Toru, Kizawa, Hiroe, Ueno-Yokohata, Hitomi, Shirai, Ryota, Yoshida, Masanori, Seki, Masafumi, Oki, Kentaro, Takita, Junko, Ogawa, Seishi, Kitamura, Toshio, Matsumoto, Kimikazu, Hata, Kenichiro, Goyama, Susumu, and Kiyokawa, Nobutaka

Published
2017
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40. Poor Prognosis With Different Induction Rate Was Observed In Children With Acute Myeloid Leukemia and FLT3-ITD According To The ITD/WT Allelic Ratio: A Result From The Japanese Pediatric Leukemia/Lymphoma Study Group

Author

Shimada, Akira, primary, Yamashita, Yuka, additional, Tomizawa, Daisuke, additional, Tawa, Akio, additional, Watanabe, Tomoyuki, additional, Yokozawa, Toshiya, additional, Kudo, Kazuko, additional, Taga, Takashi, additional, Iwamoto, Shotaro, additional, Terui, Kiminori, additional, Moritake, Hiroshi, additional, Kinoshita, Akitoshi, additional, Takahashi, Hiroyuki, additional, Nakayama, Hideki, additional, Koh, Katsuyoshi, additional, Goto, Hiroaki, additional, Kosaka, Yoshiyuki, additional, Saito, Akiko Moriya, additional, Fujimoto, Junichiro, additional, Horibe, Keizo, additional, Oki, Kentaro, additional, Hayashi, Yasuhide, additional, and Adachi, Souichi, additional

Published
2013
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41. Preliminary Evidence That Excitatory Transcranial Direct Current Stimulation Extends Time to Task Failure of a Sustained, Submaximal Muscular Contraction in Older Adults.

Author

Kentaro Oki, Mahato, Niladri K., Masato Nakazawa, Shinichi Amano, France, Christopher R., Russ, David W., Clark, Brian C., Oki, Kentaro, Nakazawa, Masato, and Amano, Shinichi

Subjects
MUSCLE contraction, FATIGUE (Physiology), MUSCLE strength, RATE of perceived exertion, OLDER people, PHYSIOLOGY, AGING, COMPARATIVE studies, ELBOW, EVOKED potentials (Electrophysiology), FRONTAL lobe, RESEARCH methodology, MEDICAL cooperation, PSYCHOLOGY of movement, RESEARCH, RESEARCH funding, TIME, EVALUATION research, RANDOMIZED controlled trials, BLIND experiment, SKELETAL muscle, MUSCLE fatigue, TRANSCRANIAL direct current stimulation
Abstract

Background: Decreased cortical excitability has been proposed as a potential mechanism underlying task failure during sustained muscular contractions, and cortical excitability may decrease with old age. We tested the hypothesis that transcranial direct current stimulation, which has been reported to raise cortical excitability, would prolong the time to task failure during a sustained muscular contraction in older adults.Methods: Thirteen older adults (68.3±2.0 years; eight women and five men) performed isometric, elbow flexions to failure while receiving sham or anodal transcranial direct current stimulation. Order of stimulation was randomized, and the subjects and investigators were blinded to condition. Time to task failure was measured alongside selected psychological indices of perceived exertion and affect.Results: Anodal transcranial direct current stimulation prolonged mean time to task failure by approximately 15% (16.9±2.2 vs 14.7±1.8 minutes) and slowed the rate of increase in rating of perceived exertion (0.29±0.03 vs 0.31±0.03) relative to the sham condition.Conclusions: These preliminary findings suggest that anodal transcranial direct current stimulation enhances time to task failure of a sustained, submaximal contraction in older adults by potentially increasing cortical excitability and/or influencing the perception of exertion. These results raise the question of whether interventions that acutely increase cortical excitability could enhance physical function and/or exercise-induced adaptations in older adults. [ABSTRACT FROM AUTHOR]

Published
2016
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44. NUP98-NSD1 Fusion Gene Is Strongly Associated with a Poor Prognosis in Pediatric Acute Myeloid Leukemia: A Study of the Japanese Childhood AML99 Cooperative Study Group

Author

Shiba, Norio, primary, Taki, Tomohiko, additional, Park, Myoung-ja, additional, Murata, Chisato, additional, Oki, Kentaro, additional, Ichikawa, Hitoshi, additional, Shimada, Akira, additional, Kanazawa, Takashi, additional, Sotomatsu, Manabu, additional, Tabuchi, Ken, additional, Adachi, Souichi, additional, Tawa, Akio, additional, Horibe, Keizo, additional, Tsuchida, Masahiro, additional, Hanada, Ryoji, additional, Tsukimoto, Ichiro, additional, Arakawa, Hirokazu, additional, and Hayashi, Yasuhide, additional

Published
2011
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45. Mutational Analysis for IDH1 and IDH2 In Pediatric Leukemia

Author

Hiwatari, Mitsuteru, primary, Oki, Kentaro, additional, Takita, Jyunko, additional, Nishimura, Riki, additional, Sanada, Masashi, additional, Okubo, Jun, additional, Adachi, Masatoki, additional, Sotomatsu, Manabu, additional, Kikuchi, Akira, additional, Igarashi, Takashi, additional, Hayashi, Yasuhide, additional, and Ogawa, Seishi, additional

Published
2010
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46. Cord Blood Transplantation from Unrelated Donors for Children with Acute Lymphoblastic Leukemia in Japan: The Impact of Methotrexate on the Clinical Outcome.

Author

Kato, Koji, primary, Yoshimi, Ayami, primary, Ito, Etsuro, primary, Oki, Kentaro, primary, Hara, Jun, primary, Nagatoshi, Yoshihisa, primary, Kikuchi, Akira, primary, Kobayashi, Ryoji, primary, Nagamura-Inoue, Tokiko, primary, Kai, Shunro, primary, Azuma, Hiroshi, primary, Takanashi, Minoko, primary, Isoyama, Keiichi, primary, and Kato, Shunichi, primary

Published
2007
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47. RARBTranslocations in Acute Promyelocytic Leukemia without Raratranslocation

Author

Kato, Motohiro, Osumi, Tomoo, Tsujimoto, Shinichi, Tamura, Moe, Uchiyama, Meri, Nakabayashi, Kazuhiko, Okamura, Kohji, Tomizawa, Daisuke, Watanabe, Akihiro, Takahashi, Hiroyuki, Hori, Tsukasa, Yamamoto, Shohei, Hamamoto, Kazuko, Migita, Masahiro, Ogata-Kawata, Hiroko, Uchiyama, Toru, Kizawa, Hiroe, Ueno-Yokohata, Hitomi, Shirai, Ryota, Yoshida, Masanori, Seki, Masafumi, Oki, Kentaro, Takita, Junko, Ogawa, Seishi, Kitamura, Toshio, Matsumoto, Kimikazu, Hata, Kenichiro, Goyama, Susumu, and Kiyokawa, Nobutaka

Abstract

Introduction: Acute promyelocytic leukemia (APL) is defined by unique morphological features, typically abnormal promyelocytes containing azurophilic granules. Genomic basis of APL is characterized by the translocation t(15;17)(q22;q21), inducing fusions between promyelocytic leukemia (PML) and retinoic acid receptor-a (RARA). APL cells with PML-RARA respond to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), and recent clinical trials have achieved excellent outcome for typical APL with PML-RARA. Although a certain fraction of APL cases lacks PMR-RARA, most of them had translocation including RARAand other genes, namely, PLZF, NPM, and TBL1XR1. Eventually, all known APL-associated translocations involve RARA, accounting for 99% of APL. However, RARArearrangement is unable to be detected in the rest of APL cases, and molecular mechanisms underlying this small subset is still unclear. We here analyzed APL cases without RARAtranslocation, and identified a novel RARBfusion in the majority of patients with RARA-negative APL.

Published
2017
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48. Identifications of Highly Aggressive Phenotype with SPI1Overexpression in Pediatric T Cell Acute Lymphoblastic Leukemia/Lymphoma

Author

Seki, Masafumi, Kimura, Shunsuke, Yoshida, Kenichi, Isobe, Tomoya, Ueno, Hiroo, Suzuki, Hiromichi, Shiozawa, Yusuke, Kataoka, Keisuke, Fujii, Yoichi, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Takagi, Masatoshi, Iwama, Atsushi, Oki, Kentaro, Kato, Motohiro, Koh, Katsuyoshi, Hanada, Ryoji, Moritake, Hiroshi, Kobayashi, Ryoji, Deguchi, Takao, Hashii, Yoshiko, Imamura, Toshihiko, Sato, Atsushi, Horibe, Keizo, Kiyokawa, Nobutaka, Manabe, Atsushi, Ohara, Akira, Sanada, Masashi, Hayashi, Yasuhide, Mano, Hiroyuki, Miyano, Satoru, Oka, Akira, Ogawa, Seishi, and Takita, Junko

Abstract

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) accounts for 10% to 15% of newly diagnosed cases of childhood acute lymphoblastic leukemia (ALL), arising from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process. However, since the prognostic significance of these genetic alterations in pediatric T-ALL is not clear, genetic basis which contributes aggressive phenotype or progression of pediatric T-ALL is still to be elucidated. Therefore, to discover driver genetic events, which involved in the aggressive phenotype of pediatric T-ALL and to identify it's novel prognostic markers, we performed integrated genetic analysis in a large cohort of T-ALL case.

Published
2016
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49. NUP98-NSD1Fusion Gene Is Strongly Associated with a Poor Prognosis in Pediatric Acute Myeloid Leukemia: A Study of the Japanese Childhood AML99 Cooperative Study Group

Author

Shiba, Norio, Taki, Tomohiko, Park, Myoung-ja, Murata, Chisato, Oki, Kentaro, Ichikawa, Hitoshi, Shimada, Akira, Kanazawa, Takashi, Sotomatsu, Manabu, Tabuchi, Ken, Adachi, Souichi, Tawa, Akio, Horibe, Keizo, Tsuchida, Masahiro, Hanada, Ryoji, Tsukimoto, Ichiro, Arakawa, Hirokazu, and Hayashi, Yasuhide

Abstract

Abstract 1475

Published
2011
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