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Your search keyword '"Okhovat, Jean-Phillip"' showing total 159 results
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159 results on '"Okhovat, Jean-Phillip"'

2. A pink enlarging plaque on the plantar foot: amelanotic acral lentiginous melanoma

Author

Okhovat, Jean-Phillip, Tahan, Steven R, and Kim, Caroline C

Subjects
amelanotic, melanoma, acral lentiginous melanoma
Abstract

Acral lentiginous melanomas account for less than 5% of all melanomas, whereas amelanotic melanomas account for around 2-8% of all melanomas. Amelanotic acral lentiginous melanomas are even less common and can often be mistaken for other clinical entities, including pyogenic granulomas, non-melanoma skin cancers, and warts. We describe a man in his 50s with a twenty-year history of a skin-colored plaque on the right plantar foot; after enlargement and failure of wart treatment, a shave biopsy revealed an amelanotic melanoma. A subsequent wide local excision and sentinel lymph node biopsy revealed melanoma in 4 lymph nodes and the patient underwent an abbreviated course of interferon-alpha therapy. The patient remained stable until 2 ? years after diagnosis, at which time he presented with in-transit metastases on the foot and right thigh; he has since been stable on nivolumab. This case represents the challenge of diagnosing amelanotic melanomas on acral surfaces and highlights the importance of considering a skin biopsy for diagnosis of any changing, atypical amelanotic lesions on the feet or hands.

Published
2019

6. Extensive Perineural Invasion vs Nerve Caliber to Assess Cutaneous Squamous Cell Carcinoma Prognosis

Author

Massey, Paul R., primary, Wang, David M., additional, Murad, Fadi, additional, Mulvaney, Patrick, additional, Moore, Kevin, additional, Okhovat, Jean-Phillip, additional, Russell-Goldman, Eleanor, additional, Lin, William M., additional, Piris, Adriano, additional, Huilgol, Shyamala C., additional, Ruiz, Emily S., additional, and Schmults, Chrysalyne D., additional

Published
2023
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8. Antimicrobial Peptides

Author

Park, Andrew J., Okhovat, Jean-Phillip, Kim, Jenny, Gaspari, Anthony A., editor, Tyring, Stephen K., editor, and Kaplan, Daniel H., editor

Published
2017
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23. Preclinical Studies Support Combined Inhibition of BET Family Proteins and Histone Deacetylases as Epigenetic Therapy for Cutaneous T-Cell Lymphoma12

Author

Zhao, Lei, Okhovat, Jean-Phillip, Hong, Eric K, Kim, Youn H., and Wood, Gary S.

Subjects
Original article, Antibiotics, Antineoplastic, Cell Survival, Proteins, Apoptosis, Drug Synergism, Histone Deacetylases, Epigenesis, Genetic, Lymphoma, T-Cell, Cutaneous, Gene Expression Regulation, Neoplastic, Histone Deacetylase Inhibitors, Inhibitory Concentration 50, Mice, Cell Line, Tumor, Depsipeptides, Animals, Humans, Cell Proliferation
Abstract

Advanced-stage cutaneous T-cell lymphoma (CTCL) is usually a fatal malignancy despite optimal use of currently available treatments. In this preclinical study of novel CTCL therapy, we performed in vitro and ex vivo experiments to determine the efficacy of combination treatment with a panel of BET bromodomain inhibitors (BETi) (JQ1, OTX015, CPI-0610, I-BET762) and HDAC inhibitors (HDACi) (SAHA/Vorinostat, Romidepsin). BETi/HDACi combinations were synergistic (combination index

Published
2018

45. Photodynamic therapy for Bowen's Disease (squamous cell carcinoma in situ) current review and update.

Author

O'Connell, Katie A., Okhovat, Jean-Phillip, and Zeitouni, Nathalie C.

Abstract

Highlights • Photodynamic therapy is an effective treatment option for Bowen's Disease. • Useful for non-surgical candidates and patients with multiple lesions. • Good clinical response rates and lower recurrence rates vs. conventional therapy. • Superior cosmetic outcome and fewer adverse events vs. conventional therapy. Abstract The aim of this review is to provide clinicians with an overview of outcomes in the current literature concerning the use of Photodynamic Therapy to treat Bowen's Disease, also known as Squamous Cell Carcinoma in situ. The review discusses clinical response, recurrence rates, cosmetic outcomes, and adverse effects. Strong evidence shows that PDT is an effective therapy for SCCis with acceptable clinical response rates and lower recurrence rates in comparison to conventional therapies such as cryotherapy and 5-fluorouracil. Furthermore, PDT is associated with superior cosmetic outcomes and is generally well tolerated by patients, with minimal side effects. PDT is especially useful in patients with multiple lesions and those whom are considered to be non-surgical candidates. [ABSTRACT FROM AUTHOR]

Published
2018
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47. Lipedema

Author

Okhovat, Jean-Phillip, primary and Alavi, Afsaneh, additional

Published
2014
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50. Evaluation of serum B-cell maturation antigen in multiple myeloma.

Author

Sanchez, Eric, primary, Li, Mingjie, additional, Kitto, Alex, additional, Li, Jennifer, additional, Wang, Cathy, additional, Kirk, Dylan T, additional, Robinson, Austin, additional, Madden, Erik, additional, Okhovat, Jean-Phillip, additional, Waterman, Gabriel N., additional, Swift, Regina A., additional, Bonavida, Benjamin, additional, Chen, Haiming, additional, and Berenson, James R., additional

Published
2012
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