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Abstract The Intergovernmental Panel on Climate Change (IPCC) has been producing influential reports for over 35 years. As the IPCC’s Seventh Assessment Report (AR7) cycle begins, we offer our perspective as former members of the IPCC Technical Support Units from Working Groups I, II & III, and the Synthesis Report on lessons learned during the Sixth Assessment Report (AR6) cycle. We identify three broad issues that, if addressed, could reinforce and sustain the IPCC in continuing its mission to comprehensively assess the scientific understanding of human-induced climate change. These are the imperative to ensure balanced representation, the importance of author recognition, and the need for improved institutional memory. Our recommendations include addressing skill and training needs, tackling barriers to participation particularly for Global South authors, and ensuring all contributors receive appropriate recognition for their efforts. We focus, in particular, on feasible incremental changes that could be implemented during AR7 without major changes to the underlying procedures that require approval by the 195 member governments that make up the IPCC.

This study assessed the effects of COVID-19 on Ghana's WASH system. It focused on low-income households and WASH sector stakeholders using Ayawaso East Municipality as a case study to document lessons from the pandemic's impact on the WASH sector. We used the water and sanitation system approach to understand the effects of COVID-19 mitigation measures on the WASH system. Data were collected through surveys, stakeholder engagements, and document analysis. We found that the government's WASH response increased hygiene practices, solid and liquid waste generation, and water consumption. Sanitation service providers experienced reduced demands for their services, lost clients, and increased operational expenditure. The pandemic's impact is gendered, with women and girls experiencing a greater burden. We argue that responses to the pandemic highlight the need and opportunities for sustainable management of sanitation waste through integrated, circular economy business models, turning waste into valuable resources. Responses to COVID-19 in the WASH system are multisectoral because of its interconnected nature, highlighting the need to integrate sectors beyond water and sanitation. This requires improved institutional structures, policies, investment, and professionalising service providers. HIGHLIGHTS Government's WASH response to COVID-19 increased hygiene practices.; A holistic approach to managing all aspects of WASH is vital.; Effective COVID-19 responses require effective inter-agency cooperation.; Social inclusion and support to marginalised groups is critical to deal with a pandemic.; Investments along the whole service delivery chain are needed to improve wastewater management.;

The climate crisis has migration implications, and we need to act inclusively and urgently. Climate change impacts people’s decisions to migrate largely through economic, political, technological, demographic, and socio-cultural factors, and their dynamic interlinkages. These complex issues often influence climate risks and vulnerabilities and complicate effective investment and policy actions on migration. However, there is inadequate documentation on how climate change is linked to migration and social transformation. Based on a traditional literature review and inputs from a consultation dialogue, this paper analyzes climate-induced migration in West Africa using a social transformation lens. The paper conceptualizes the climate-induced migrant as an agent of adaptation and describes the complexities of climate vulnerabilities, and its intersection with social transformation in migration decisions. A social transformation conceptual framework is proposed to identify the complexities of climate-induced migration and ensure inclusive strategies are planned, implemented, and sustained. The paper discusses the need for transdisciplinary research approaches to capture various intersections of transforming socio-economic and environmental vulnerabilities across different countries and migratory landscapes. The paper also highlights the critical concern in the region regarding the “trapped population.” It suggests that a social transformation lens is required to unravel the dynamics around vulnerable people unable to migrate because they do not have the resources to migrate or are constrained by cultural issues.

There is mounting evidence that cancer patients co-administer herbal drugs with chemotherapy, however, information on the pharmacodynamic (PD) effects of such combination therapy is scarce. Natural products including crude extracts, herbal formulas, and bioactive compounds from plants hold great potential to prevent and treat cancers. More importantly, some herbal drugs can reduce the incidence of chemotherapy-induced toxicity including oral mucositis, gastrointestinal toxicity, hepatotoxicity etc. This review focuses on the effectiveness of some herbal products as adjuvant therapy and describes the possible mechanisms of chemo-herbal drug PD interactions in enhancing the efficacy/ or reducing the side effects of chemotherapy. We also highlighted recent advances in preclinical in vitro and in vivo studies to establish the effectiveness of herbal medicine to enhance efficacy or counteract chemotherapy-induced side effects. In addition, we draw particular attention to the synergistic effects of chemo-herbal drug combination therapy to prevent and treat cancers using evidence from clinical trials. We concluded that herbal drugs hold great potential as adjuvant therapy for the prevention and treatment of chemotherapy-induced side effects. It is important to also highlight that the clinical evidence on chemo-herbal drug combination therapy is limited. There is an urgent need for an in-depth PD evaluation including the safety pharmacology of chemo-herbal drug combination therapy as well as reliable evidence from multicentre clinical trials to establish the beneficial or negative effects of chemo-herbal drug combination therapy in the ongoing fight against cancer.

This study reviewed the impact of the coronavirus disease 2019 (COVID-19) on pre-existing vulnerabilities in rural communities using the scoping review strategy. It focused on manuscripts published on the topic in 2020. Based on 39 studies that met our inclusion criteria (out of 507 studies), we note that COVID-19 is exacerbating pre-existing rural vulnerabilities, including poverty, remoteness, socio-economic marginalisation and high unemployment. There is limited evidence that rural communities are resilient to the pandemic. Reduction in household expenditures and the community food system are the only reported forms of resilience. Although local institutions are supporting rural communities in responding to the impacts of the pandemic, several institutional dynamics undermine the effectiveness of the response. The increased risk of the pandemic is likely to reduce incomes and standards of living amongst poor communities. Thus, coping strategies were identified such as starting small gardens in communities, diet changes, targeting community markets with produce rather than retailers and food swap using social media, with food swap being the most adopted coping strategy. Although this study does not offer a comprehensive picture of the levels and nature of vulnerability, resilience and institutional dynamics of rural communities in different parts of the world reveal the limitations of existing knowledge of the vulnerability of rural communities in the context of COVID-19. This underscores the importance of further studies on rural vulnerability in the context of COVID-19 that will enable evidence-based responses to the pandemic in rural contexts.

The climate crisis has migration implications, and we need to act inclusively and urgently. Climate change impacts people's decisions to migrate largely through economic, political, technological, demographic, and socio-cultural factors, and their dynamic interlinkages. These complex issues often influence climate risks and vulnerabilities and complicate effective investment and policy actions on migration. However, there is inadequate documentation on how climate change is linked to migration and social transformation. Based on a traditional literature review and inputs from a consultation dialogue, this paper analyzes climate-induced migration in West Africa using a social transformation lens. The paper conceptualizes the climate-induced migrant as an agent of adaptation and describes the complexities of climate vulnerabilities, and its intersection with social transformation in migration decisions. A social transformation conceptual framework is proposed to identify the complexities of climate-induced migration and ensure inclusive strategies are planned, implemented, and sustained. The paper discusses the need for transdisciplinary research approaches to capture various intersections of transforming socio-economic and environmental vulnerabilities across different countries and migratory landscapes. The paper also highlights the critical concern in the region regarding the "trapped population." It suggests that a social transformation lens is required to unravel the dynamics around vulnerable people unable to migrate because they do not have the resources to migrate or are constrained by cultural issues. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic, which has been primarily analysed within urban contexts, has revealed a significant gap in understanding its ramifications within rural areas. This study aims to address this gap by drawing upon the principles of Resilience Theory to shed light on the repercussions of the pandemic in rural contexts, thereby highlighting an overlooked aspect. This research employs a qualitative paradigm grounded in primary data collected from two rural municipalities, Matatiele and Winnie Madikizela Mandela Local Municipalities, in South Africa's Eastern Cape Province. The primary data is derived from 11 focus group interviews involving essential stakeholders and 13 individual interviews that were purposefully selected. The study unravels a spectrum of adverse impacts from the COVID-19 pandemic across the two municipalities by thematically transcribing and coding audio records of interviews and focus groups using NVivo, employing inductive and deductive coding approaches. These impacts include employment loss, bereavement, food insecurity, and an upsurge in reported cases of gender-based violence. The pandemic's ripples extend to cultural practices, education, and community well-being, as evidenced by the waning participation in cultural traditions, declining interest in education among school-goers, and a surge in substance abuse and criminal activities like stock theft. In light of these findings, the study advocates for customised pandemic responses in rural areas underpinned by the Resilience Theory framework. This entails endorsing enhanced healthcare infrastructure, fostering community-driven surveillance, promoting diversified livelihood strategies, and bolstering local governance structures. As the study expands our understanding, it concurrently underscores the significance of further exploration. The proposed avenue of research lies in examining how collaborative efforts among rural-based institutions can augment community resilience against the dual challenges of pandemics and disasters. Through this lens, the study emphasises the imperative of building adaptive capacity within rural communities, emphasising their ability to navigate uncertainties and emerge stronger in adversity. [ABSTRACT FROM AUTHOR]

While there is growing interest in the literature and policy circles regarding the performance of cooperatives in South Africa, no study has yet synthesised the body of knowledge on how to assess cooperative performance in the country. This paper aims to fill this gap by examining the literature on the performance of cooperatives in post-apartheid South Africa, based on a scoping review of 20 studies published between 1994 and 2021. Most of the reviewed studies adopted a qualitative approach, lacked a clear definition of cooperative performance and standardised metrics/criteria for assessing cooperative performance. The studies often relied on view of study participants to determine the performance of cooperatives. Moreover, the reviewed studies often framed the performance of cooperatives from an economic viewpoint. Clear definition of cooperatives, the development of robust indicators for assessing their performance and greater emphasis on quantitative studies on the performance of cooperatives in South Africa beyond economic and financial indicators is needed. [ABSTRACT FROM AUTHOR]

Reliable estimation of stature from skeletal remains will continue to play an important role in assessing a variety of forensic anthropological and archaeological issues. In the present study, we studied and collated data on the morphometry of the tibia as well as analyzing its segment that shows significant correlation with its maximum length and consequently formulating linear regression equations for estimating maximum tibia length (MTL) which is specific for the Nigeria population. A total number of 68 intact adult human tibia bones were used (35 right and 33 left). Thirteen anthropometric parameters were measured including the MTL. The mean differences between right and left bones of all the measured parameter were not statistically significant except for the mean shaft circumference. The correlation coefficient between MTL and the bicondylar tibial width (BTW), anterior-posterior intercondylar diameter (APID), anterior-posterior diameter of medial condyle (APDMC), midshaft transverse diameter (MSTD), and distal articular surface length (DASL) were seen to be significant (P < 0.05) only in the right tibia; therefore, the linear regression equations for estimation of MTL from these parameters for the right tibia were also significant (P < 0.05). The results of our study concluded that it is possible to estimate the maximum length of the right tibia from the BTW, APID, APDMC, MSTD, and DASL with relative accuracy. Our study may be useful for forensic investigations for the identification of the remains of unknown bodies in a Nigerian population.

Melanoma is the least common form of skin cancer and is associated with the highest mortality. Where melanoma is mostly unresponsive to conventional therapies (e.g., chemotherapy), BRAF inhibitor treatment has shown improved therapeutic outcomes. Photodynamic therapy (PDT) relies on a light-activated compound to produce death-inducing amounts of reactive oxygen species (ROS). Their capacity to selectively accumulate in tumor cells has been confirmed in melanoma treatment with some encouraging results. However, this treatment approach has not reached clinical fruition for melanoma due to major limitations associated with the development of resistance and subsequent side effects. These adverse effects might be bypassed by immunotherapy in the form of antibody–drug conjugates (ADCs) relying on the ability of monoclonal antibodies (mAbs) to target specific tumor-associated antigens (TAAs) and to be used as carriers to specifically deliver cytotoxic warheads into corresponding tumor cells. Of late, the continued refinement of ADC therapeutic efficacy has given rise to photoimmunotherapy (PIT) (a light-sensitive compound conjugated to mAbs), which by virtue of requiring light activation only exerts its toxic effect on light-irradiated cells. As such, this review aims to highlight the potential clinical benefits of various armed antibody-based immunotherapies, including PDT, as alternative approaches for the treatment of metastatic melanoma.