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9. Clinical impact of walking capacity on the risk of disability and hospitalizations among elderly patients with advanced lung cancer

Author

Okayama, Taro, Naito, Tateaki, Yonenaga, Yusuke, Ohashi, Takuya, Kitagawa, Midori, Mitsuhashi, Noriko, Ishi, Takeshi, Fuseya, Hiroshi, Aoyama, Takashi, Notsu, Akifumi, Mori, Keita, Mamesaya, Nobuaki, Kawamura, Takahisa, Kobayashi, Haruki, Omori, Shota, Wakuda, Kazushige, Ono, Akira, Kenmotsu, Hirotsugu, Murakami, Haruyasu, Tanuma, Akira, and Takahashi, Toshiaki

Published
2021
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13. A randomized phase II study of nutritional and exercise treatment for elderly patients with advanced non-small cell lung or pancreatic cancer: the NEXTAC-TWO study protocol

Author

Miura, Satoru, Naito, Tateaki, Mitsunaga, Shuichi, Omae, Katsuhiro, Mori, Keita, Inano, Toshimi, Yamaguchi, Teiko, Tatematsu, Noriatsu, Okayama, Taro, Morikawa, Ayumu, Mouri, Takako, Tanaka, Hisashi, Kimura, Madoka, Imai, Hisao, Mizukami, Takuro, Imoto, Akira, Kondoh, Chihiro, Shiotsu, Shinsuke, Okuyama, Hiroyuki, Ueno, Makoto, Takahashi, Toshiaki, Tsuji, Tetsuya, Aragane, Hideki, Inui, Akio, Higashiguchi, Takashi, and Takayama, Koichi

Published
2019
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19. Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer

Author

Yonenaga, Yusuke, primary, Naito, Tateaki, additional, Okayama, Taro, additional, Kitagawa, Midori, additional, Mitsuhashi, Noriko, additional, Ishii, Takeshi, additional, Fuseya, Hiroshi, additional, Inano, Toshimi, additional, Morikawa, Ayumu, additional, Sugiyama, Miwa, additional, Mori, Keita, additional, Notsu, Akifumi, additional, Kawabata, Takanori, additional, Ono, Akira, additional, Kenmotsu, Hirotsugu, additional, Murakami, Haruyasu, additional, Tanuma, Akira, additional, and Takahashi, Toshiaki, additional

Published
2021
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20. Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer

Author

Yonenaga,Yusuke, Naito,Tateaki, Okayama,Taro, Kitagawa,Midori, Mitsuhashi,Noriko, Ishii,Takeshi, Fuseya,Hiroshi, Inano,Toshimi, Morikawa,Ayumu, Sugiyama,Miwa, Mori,Keita, Notsu,Akifumi, Kawabata,Takanori, Ono,Akira, Kenmotsu,Hirotsugu, Murakami,Haruyasu, Tanuma,Akira, Takahashi,Toshiaki, Yonenaga,Yusuke, Naito,Tateaki, Okayama,Taro, Kitagawa,Midori, Mitsuhashi,Noriko, Ishii,Takeshi, Fuseya,Hiroshi, Inano,Toshimi, Morikawa,Ayumu, Sugiyama,Miwa, Mori,Keita, Notsu,Akifumi, Kawabata,Takanori, Ono,Akira, Kenmotsu,Hirotsugu, Murakami,Haruyasu, Tanuma,Akira, and Takahashi,Toshiaki

Abstract

Yusuke Yonenaga,1 Tateaki Naito,2 Taro Okayama,1 Midori Kitagawa,1 Noriko Mitsuhashi,1 Takeshi Ishii,1 Hiroshi Fuseya,1 Toshimi Inano,3 Ayumu Morikawa,4 Miwa Sugiyama,4 Keita Mori,5 Akifumi Notsu,5 Takanori Kawabata,5 Akira Ono,2 Hirotsugu Kenmotsu,2 Haruyasu Murakami,2 Akira Tanuma,6 Toshiaki Takahashi2 1Division of Rehabilitation Medicine, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 2Division of Thoracic Oncology, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 3Division of Nutrition, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 4Division of Nursing, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 5Clinical Research Center, Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, Japan; 6Department of Rehabilitation Medicine, Juntendo Shizuoka Hospital, Juntendo University School of Medicine, Izunokuni-shi, Shizuoka, JapanCorrespondence: Tateaki NaitoDivision of Thoracic Oncology, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi-cho, Shizuoka, 411-8777, JapanTel +81-55-989-5222Fax +81-55-989-5783Email t.naito@scchr.jpPurpose: This prospective observational study aimed to explore the influence of physical inactivity during initial chemotherapy on the risk of disability and hospitalization in later life among older patients with advanced non-small-cell lung cancer (NSCLC).Patients and Methods: Patients aged 70 or above who were scheduled to receive first-line chemotherapy for newly diagnosed advanced NSCLC were recruited for the study. An electronic pedometer was used to measure daily steps; based on the change rate (cutoff: − 12.5%) from pretreatment to 12 ± 4 weeks after enrolment, patients were classified as active or inactive. The Barthel Index estimated activities of daily living. We compared disability-free survival time, mean cumulative functions of hospital stays, and medical costs, between the active and inactive groups.Results: Among the 29 patients enrolled, 21 were evaluable. Compared with active

Published
2021

21. Additional file 2: of A randomized phase II study of nutritional and exercise treatment for elderly patients with advanced non-small cell lung or pancreatic cancer: the NEXTAC-TWO study protocol

Author

Miura, Satoru, Tateaki Naito, Mitsunaga, Shuichi, Omae, Katsuhiro, Mori, Keita, Inano, Toshimi, Teiko Yamaguchi, Noriatsu Tatematsu, Okayama, Taro, Morikawa, Ayumu, Mouri, Takako, Tanaka, Hisashi, Kimura, Madoka, Imai, Hisao, Mizukami, Takuro, Imoto, Akira, Kondoh, Chihiro, Shiotsu, Shinsuke, Okuyama, Hiroyuki, Ueno, Makoto, Takahashi, Toshiaki, Tsuji, Tetsuya, Aragane, Hideki, Inui, Akio, Higashiguchi, Takashi, and Takayama, Koichi

Abstract

A list of ethical committees. A list of ethics committees, date of approval, and reference numbers. (DOCX 15 kb)

Published
2019
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22. Additional file 1: of A randomized phase II study of nutritional and exercise treatment for elderly patients with advanced non-small cell lung or pancreatic cancer: the NEXTAC-TWO study protocol

Author

Miura, Satoru, Tateaki Naito, Mitsunaga, Shuichi, Omae, Katsuhiro, Mori, Keita, Inano, Toshimi, Teiko Yamaguchi, Noriatsu Tatematsu, Okayama, Taro, Morikawa, Ayumu, Mouri, Takako, Tanaka, Hisashi, Kimura, Madoka, Imai, Hisao, Mizukami, Takuro, Imoto, Akira, Kondoh, Chihiro, Shiotsu, Shinsuke, Okuyama, Hiroyuki, Ueno, Makoto, Takahashi, Toshiaki, Tsuji, Tetsuya, Aragane, Hideki, Inui, Akio, Higashiguchi, Takashi, and Takayama, Koichi

Abstract

Additional information for exercise prescription. Appendix 1A: the algorism of prescribe exercise program at T1 point. Appendix 1B: the level of prescribe exercise program. Appendix 1C: modified Borg scale. Appendix 1D: the algorism of prescribe exercise program at T2â 4 point. Appendix 1E: the algorism of prescribe target steps. (PPTX 52 kb)

Published
2019
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23. 12 - REDUCTION IN QUALITY OF SKELETAL MUSCLE MAY HAVE AN UNFAVORABLE IMPACT ON FUNCTIONAL PROGNOSIS IN PATIENTS WITH METASTATIC SPINE TUMORS RECEIVING NON-SURGICAL TREATMENT

Author

Kitagawa, Midori, primary, Tsuji, Tetsuya, primary, Okayama, Taro, primary, Masuda, Yoshiyuki, primary, Ishii, Takeshi, primary, Mitsuhashi, Noriko, primary, Yonenaga, Yusuke, primary, Konishi, Nobuko, primary, Naito, Tateaki, primary, Katagiri, Hirohisa, primary, Tanuma, Akira, primary, and Liu, Meigen, primary

Published
2019
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24. PERFORMANCE-ADJUSTED LIFE YEARS MAY SUBSTITUTE FOR QUALITY-ADJUSTED LIFE YEARS IN COST-EFFECTIVENESS ANALYSIS FOR ELDERLY PATIENTS WITH ADVANCED LUNG CANCER

Author

Naito, Tateaki, primary, Notsu, Akifumi, primary, Okayama, Taro, primary, Yonenaga, Yusuke, primary, Kawamura, Takahisa, primary, Kawabata, Takanori, primary, Aoyama, Takashi, primary, Murakami, Haruyasu, primary, Kenmotsu, Hirotsugu, primary, Ono, Akira, primary, Kobayashi, Haruki, primary, Omori, Shota, primary, Wakuda, Kazushige, primary, Mamesaya, Nobuaki, primary, Miyawaki, Eriko, primary, Miyawaki, Taichi, primary, Takahashi, Toshiaki, primary, and Nakashima, Kazuhisa, primary

Published
2019
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25. Development Of Low-Intensity Home-Based Resistance Training Combined With Physical Activity Counseling For Elderly Patients With Advanced Cancer : The Exercise Component Of The Nextac Program

Author

Okayama, Taro

Abstract

Introduction:The NEXTAC program was a multimodal intervention for elderly patients with advanced cancer to maintain their nutritional status and physical function during systemic chemotherapy.ObjectivesThe aim of this presentation is to show algorithm of the exercise-prescription and its compliance.MethodsExercise-intervention combines daily low-intensity resistance training with physical-activity counseling using accelerometer. Three educational sessions were planned in 8-week study period. Exercise-prescription consists of 3 or 5 of following 5 exercises: sit-to-stand, calf-raise, knee-extension, knee-raise, and side-leg-raise with or without ankle-weight. Physiotherapist chose optimal prescription according to the modified Borg-scale. Patients performed each exercise 10-times repetition for 3sets a day at home. A target step was calculated as adding 2000 steps on the average patientu2019s steps with a maximum of 8000 steps. Instructors counseled patient to promote their indoor and outdoor activity. Compliance was assessed by diary.ResultsTwenty-eight out of 30 patients attended all exercise sessions. Median proportion of days in which patients completed full of exercise program and performed full or modified exercise program was 41 and 91%, respectively. Patients skipped or modified exercise program mainly due to feeling unmotivated or too ill to perform exercise. Patients kept or increased indoor or outdoor activity in 79 and 69 % at the end of intervention, respectively. As a result, time spent in physical activity (u22651.8 METs) increased in 69 % of patients.ConclusionsOur exercise program was feasible and promoted patient's voluntary participation in physical-activity for the elderly patients with advanced cancer. (Grant-in-Aid from Japan Agency for Medical Research and Development, Trial Registration No.UMIN000023207)

Published
2017

26. Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non‐small‐cell lung cancer

Author

Naito, Tateaki, primary, Mitsunaga, Shuichi, additional, Miura, Satoru, additional, Tatematsu, Noriatsu, additional, Inano, Toshimi, additional, Mouri, Takako, additional, Tsuji, Tetsuya, additional, Higashiguchi, Takashi, additional, Inui, Akio, additional, Okayama, Taro, additional, Yamaguchi, Teiko, additional, Morikawa, Ayumu, additional, Mori, Naoharu, additional, Takahashi, Toshiaki, additional, Strasser, Florian, additional, Omae, Katsuhiro, additional, Mori, Keita, additional, and Takayama, Koichi, additional

Published
2018
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28. A randomized phase II study of the nutritional and exercise treatment for the elderly patients with advanced non-small cell lung or pancreatic cancer: The NEXTAC-TWO study.

Author

Miura, Satoru, primary, Naito, Tateaki, additional, Mitsunaga, Shuichi, additional, Omae, Katsuhiro, additional, Mori, Keita, additional, Inano, Toshimi, additional, Yamaguchi, Teiko, additional, Mori, Naoharu, additional, Tatematsu, Noriatsu, additional, Okayama, Taro, additional, Morikawa, Ayumu, additional, Mouri, Takako, additional, Tsuji, Tetsuya, additional, Aragane, Hideki, additional, Inui, Akio, additional, Higashiguchi, Takashi, additional, and Takayama, Koichi, additional

Published
2018
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29. Development of Low-intensity Home-based Resistance Training for Elderly Patients with Advanced Cancer: The Exercise Component of the NEXTAC Program

Author

Tatematsu, Noriatsu, primary, Okayama, Taro, additional, Tsuji, Tetsuya, additional, Iwamura, Akira, additional, Tanuma, Akira, additional, Naito, Tateaki, additional, Mitsunaga, Shuichi, additional, Miura, Satoru, additional, Omae, Katsuhiro, additional, Mori, Keita, additional, and Takayama, Koichi, additional

Published
2018
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30. Unfavorable impact of cancer cachexia on activity of daily living and need for inpatient care in elderly patients with advanced non-small-cell lung cancer in Japan: a prospective longitudinal observational study

Author

Naito, Tateaki, primary, Okayama, Taro, additional, Aoyama, Takashi, additional, Ohashi, Takuya, additional, Masuda, Yoshiyuki, additional, Kimura, Madoka, additional, Shiozaki, Hitomi, additional, Murakami, Haruyasu, additional, Kenmotsu, Hirotsugu, additional, Taira, Tetsuhiko, additional, Ono, Akira, additional, Wakuda, Kazushige, additional, Imai, Hisao, additional, Oyakawa, Takuya, additional, Ishii, Takeshi, additional, Omori, Shota, additional, Nakashima, Kazuhisa, additional, Endo, Masahiro, additional, Omae, Katsuhiro, additional, Mori, Keita, additional, Yamamoto, Nobuyuki, additional, Tanuma, Akira, additional, and Takahashi, Toshiaki, additional

Published
2017
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32. Skeletal muscle depletion during chemotherapy has a large impact on physical function in elderly Japanese patients with advanced non–small-cell lung cancer

Author

Naito, Tateaki, primary, Okayama, Taro, additional, Aoyama, Takashi, additional, Ohashi, Takuya, additional, Masuda, Yoshiyuki, additional, Kimura, Madoka, additional, Shiozaki, Hitomi, additional, Murakami, Haruyasu, additional, Kenmotsu, Hirotsugu, additional, Taira, Tetsuhiko, additional, Ono, Akira, additional, Wakuda, Kazushige, additional, Imai, Hisao, additional, Oyakawa, Takuya, additional, Ishii, Takeshi, additional, Omori, Shota, additional, Nakashima, Kazuhisa, additional, Endo, Masahiro, additional, Omae, Katsuhiro, additional, Mori, Keita, additional, Yamamoto, Nobuyuki, additional, Tanuma, Akira, additional, and Takahashi, Toshiaki, additional

Published
2017
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33. Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non‐small‐cell lung cancer.

Author

Naito, Tateaki, Mitsunaga, Shuichi, Miura, Satoru, Tatematsu, Noriatsu, Inano, Toshimi, Mouri, Takako, Tsuji, Tetsuya, Higashiguchi, Takashi, Inui, Akio, Okayama, Taro, Yamaguchi, Teiko, Morikawa, Ayumu, Mori, Naoharu, Takahashi, Toshiaki, Strasser, Florian, Omae, Katsuhiro, Mori, Keita, and Takayama, Koichi

Subjects
DISEASES in older people, PANCREATIC cancer, NON-small-cell lung carcinoma, EXERCISE, DIET in disease
Abstract

Background: Combinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme. Methods: This was a multicentre prospective single‐arm study. We recruited 30 of 46 screened patients aged ≥70 years scheduled to receive first‐line chemotherapy for newly diagnosed, advanced pancreatic, or non‐small‐cell lung cancer. Physical activity was measured using pedometers/accelerometer (Lifecorder®, Suzuken Co., Ltd., Japan). An 8 week educational intervention comprised three exercise and three nutritional sessions. The exercise interventions combined home‐based low‐intensity resistance training and counselling to promote physical activity. Nutritional interventions included standard nutritional counselling and instruction on how to manage symptoms that interfere with patient's appetite and oral intake. Supplements rich in branched‐chain amino acids (Inner Power®, Otsuka Pharmaceutical Co., Ltd., Japan) were provided. The primary endpoint of the study was feasibility, which was defined as the proportion of patients attending ≥4 of six sessions. Secondary endpoints included compliance and safety. Results: The median patient age was 75 years (range, 70–84). Twelve patients (40%) were cachectic at baseline. Twenty‐nine patients attended ≥4 of the six planned sessions (96.7%, 95% confidence interval, 83.3 to 99.4). One patient dropped out due to deteriorating health status. The median proportion of days of compliance with supplement consumption and exercise performance were 99% and 91%, respectively. Adverse events possibly related to the NEXTAC programme were observed in five patients and included muscle pain (Grade 1 in two patients), arthralgia (Grade 1 in one patient), dyspnoea on exertion (Grade 1 in one patient), and plantar aponeurositis (Grade 1 in one patient). Conclusions: The early induction of multimodal interventions showed excellent compliance and safety in elderly patients with newly diagnosed pancreatic and non‐small‐cell lung cancer receiving concurrent chemotherapy. We are now conducting a randomized phase II study to measure the impact of these interventions on functional prognosis. [ABSTRACT FROM AUTHOR]

Published
2019
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38. Zinc Finger Protein Gfi1 Controls the Endotoxin-Mediated Toll-Like Receptor Inflammatory Response by Antagonizing NF-κB p65

Author

Sharif-Askari, Ehssan, primary, Vassen, Lothar, additional, Kosan, Christian, additional, Khandanpour, Cyrus, additional, Gaudreau, Marie-Claude, additional, Heyd, Florian, additional, Okayama, Taro, additional, Jin, Jianmin, additional, Rojas, Meghan E. B., additional, Grimes, H. Leighton, additional, Zeng, Hui, additional, and Möröy, Tarik, additional

Published
2010
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43. Hematologic Abnormalities and Outcome of 16 Cats with Myelodysplastic Syndromes

Author

Hisasue, Masaharu, primary, Okayama, Hiromi, additional, Okayama, Taro, additional, Suzuki, Takafumi, additional, Mizuno, Takuya, additional, Fujino, Yasuhito, additional, Naganobu, Kiyokazu, additional, Hasegawa, Atsuhiko, additional, Watari, Toshihiro, additional, Matsuki, Naoaki, additional, Masuda, Kenichi, additional, Ohno, Koichi, additional, and Tsujimoto, Hajime, additional

Published
2001
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44. Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1

Author

Vassen, Lothar, Okayama, Taro, and Möröy, Tarik

Abstract

Gfi1b and Gfi1 are 37- and 55-kDa transcriptional repressors that share common features such as a 20-amino acid (aa) N-terminal SNAG domain, a nonconserved intermediary domain, and 6 highly conserved C-terminal zinc fingers. Both gene loci are under autoregulatory and cross-regulatory feedback control. We have generated a reporter mouse strain by inserting the cDNA for green fluorescent protein (GFP) into the Gfi1b gene locus which allowed us to follow Gfi1b expression during hematopoiesis and lymphopoiesis by measuring green fluorescence. We found highly dynamic expression patterns of Gfi1b in erythroid cells, megakaryocytes, and their progenitor cells (MEPS) where Gfi1 is not detected. Vice versa, Gfi1b could not be found in granulocytes, activated macrophages, or their granulomonocytic precursors (GMPs) or in mature naive or activated lymphocytes where Gfi1 is expressed, suggesting a complementary regulation of both loci during hematopoiesis. However, Gfi1b was found to be up-regulated in early stages of B-cell and in a subset of early T-cell development, where Gfi1 is also present, suggesting that cross-regulation of both loci exists but is cell-type specific.

Published
2007
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45. Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65.

Author

Sharif-Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau MC, Heyd F, Okayama T, Jin J, Rojas ME, Grimes HL, Zeng H, and Möröy T

Subjects
Animals, Base Sequence, Cell Line, DNA genetics, DNA metabolism, DNA Primers genetics, DNA-Binding Proteins antagonists & inhibitors, DNA-Binding Proteins deficiency, DNA-Binding Proteins genetics, Humans, Immunity, Innate drug effects, Inflammation etiology, Lipopolysaccharides toxicity, Macrophages immunology, Macrophages metabolism, Mice, Mice, Inbred C57BL, Mice, Knockout, Promoter Regions, Genetic, RNA, Messenger genetics, RNA, Messenger metabolism, Shock, Septic etiology, Shock, Septic immunology, Shock, Septic metabolism, Signal Transduction, Transcription Factors antagonists & inhibitors, Transcription Factors deficiency, Transcription Factors genetics, Transcriptional Activation, Tumor Necrosis Factor-alpha genetics, Zinc Fingers, DNA-Binding Proteins metabolism, Inflammation immunology, Inflammation metabolism, Toll-Like Receptors metabolism, Transcription Factor RelA antagonists & inhibitors, Transcription Factors metabolism
Abstract

Endotoxin (bacterial lipopolysaccharide [LPS]) causes fatal septic shock via the Toll-like receptor 4 (TLR-4) protein present on innate immunity effector cells, which activates nuclear factor kappa B (NF-kappaB), inducing proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha). An early step in this process involves nuclear sequestration of the p65-RelA NF-kappaB subunit, enabling transcriptional activation of target inflammatory cytokine genes. Here, we analyzed the role of the nuclear zinc finger protein Gfi1 in the TLR response using primary bone marrow-derived macrophages. We show that upon LPS stimulation, expression of Gfi1 is induced with kinetics similar to those of nuclear translocation of p65 and that Gfi1 interacts with p65 and inhibits p65-mediated transcriptional transactivation by interfering with p65 binding to target gene promoter DNA. Gfi1-deficient macrophages show abnormally high mRNA levels of the TNF-alpha gene and many other p65 target genes and a higher rate of TNF promoter occupancy by p65 than wild-type cells after LPS stimulation, suggesting that Gfi1 functions as an antagonist of NF-kappaB activity at the level of promoter binding. Our findings identify a new function of Gfi1 as a general negative regulator of the endotoxin-initiated innate immune responses, including septic shock and possibly other severe inflammatory diseases.

Published
2010
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