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1. FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms

Author

Uittenbogaard, Paula, Netea, Stejara A, Tanck, Michael WT, Geissler, Judy, Buda, Piotr, Kowalczyk-Domagała, Monika, Okarska-Napierała, Magdalena, van Stijn, Diana, Tacke, Carline E, Consortium, Kawasaki Disease Genetics, Burgner, David P, Shimizu, Chisato, Burns, Jane C, Kuipers, Irene M, Kuijpers, Taco W, and Nagelkerke, Sietse Q

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Human Genome, Cardiovascular, Heart Disease - Coronary Heart Disease, Genetic Testing, Autoimmune Disease, Rare Diseases, Immunization, Infectious Diseases, Heart Disease, Pediatric, 2.1 Biological and endogenous factors, Humans, Mucocutaneous Lymph Node Syndrome, Receptors, IgG, Immunoglobulins, Intravenous, Genetic Predisposition to Disease, Coronary Aneurysm, Male, Polymorphism, Single Nucleotide, Female, Child, Preschool, Drug Resistance, Child, Infant, Case-Control Studies, DNA Copy Number Variations, Kawasaki disease, IVIg, CAA, FCGR2, FCGR3, genetics, FCGR2Ap.His166Arg, US Kawasaki Disease Genetics Consortium, Immunology, Medical Microbiology, Biochemistry and cell biology
Abstract

IntroductionKawasaki disease (KD) is a pediatric vasculitis that can result in coronary artery aneurysm (CAA) formation, which is a dangerous complication. Treatment with intravenous immunoglobulin (IVIg) significantly decreases the risk of CAA, possibly through competitive binding to Fc-gamma receptors (FcγRs), which reduces the binding of pathological immune complexes. However, ~20% of children have recrudescence of fever and have an increased risk of CAA. Therefore, we aimed to identify genetic markers at the FCGR2/3 locus associated with susceptibility to KD, IVIg resistance, or CAA.Materials and methodsWe investigated the association of single-nucleotide polymorphisms (SNPs) and copy number variations (CNVs) at the FCGR2/3 locus with KD susceptibility, IVIg resistance, and CAA risk using a family-based test (KD susceptibility) and case-control analyses (IVIg resistance and CAA risk) in different cohorts, adding up to a total of 1,167 KD cases. We performed a meta-analysis on IVIg resistance and CAA risk including all cohorts supplemented by previous studies identified through a systematic search.ResultsFCGR2A-p.166His was confirmed to be strongly associated with KD susceptibility (Z = 3.17, p = 0.0015). In case-control analyses, all of the investigated genetic variations at the FCGR2/3 locus were generally not associated with IVIg resistance or with CAA risk, apart from a possible association in a Polish cohort for the FCGR3B-NA2 haplotype (OR = 2.15, 95% CI = 1.15-4.01, p = 0.02). Meta-analyses of all available cohorts revealed no significant associations of the FCGR2/3 locus with IVIg resistance or CAA risk.DiscussionFCGR2/3 polymorphisms are associated with susceptibility to KD but not with IVIg resistance and CAA formation. Currently known genetic variations at the FCGR2/3 locus are not useful in prediction models for IVIg resistance or CAA risk.

Published
2024

6. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Author

Chouli, Mohamed, Hamadouche, Nacera, Ladj, Mohamed Samir, Agrimbau Vázquez, Jorge, Carmona, Rodrigo, Collia, Adrian Gustavo, Ellis, Alejandro, Natta, Diego, Pérez, Laura, Rubiños, Mayra, Veliz, Natalia, Yori, Silvana, Britton, Philip N., Burgner, David P., Carey, Emma, Crawford, Nigel W., Giuliano, Hayley, McMinn, Alissa, Wong, Shirley, Wood, Nicholas, Holter, Wolfgang, Krainz, Matthias, Ulreich, Raphael, Zurl, Christoph, Dehoorne, Joke, Haerynck, Filomeen, Hoste, Levi, Schelstraete, Petra, Vandekerckhove, Kristof, Willems, Jef, Almeida Farias, Camila Giuliana, Almeida, Flávia Jacqueline, Alves Leal, Izabel, Araujo da Silva, André Ricardo, Araujo e Silva, Anna Esther, Barreiro, Sabrina T.A., Bomfim Prado da Silva, Daniella Gregória, Cervi, Maria Celia, dos Santos Naja Cardoso, Mirian Viviane, Henriques Teixeira, Cristiane, Jarovsky, Daniel, Martins Araujo, Julienne, Naaman Berezin, Eitan, Palazzi Sáfadi, Marco Aurélio, Paternina-de la Ossa, Rolando Andres, Souza Vieira, Cristina, Dimitrova, Anna, Ganeva, Margarita, Stefanov, Stefan, Telcharova-Mihaylovska, Albena, Biggs, Catherine M., Lopez, Alison, Scuccimarri, Rosie, Tan, Ryan, Wasserman, Sam, Withington, Davinia, Ampuero, Camila, Aravena, Javiera, Bustos B, Raul, Casanova, Daniel, Cruces, Pablo, Diaz, Franco, García-Salum, Tamara, Godoy, Loreto, Medina, Rafael A., Valenzuela Galaz, Gonzalo, Camacho-Moreno, Germán, Avila-Aguero, María L., Brenes-Chacón, Helena, Camacho-Badilla, Kattia, Ivankovich-Escoto, Gabriela, Naranjo-Zuniga, Gabriela, Soriano-Fallas, Alejandra, Ulloa-Gutierrez, Rolando, Yock-Corrales, Adriana, Amer, Maysa Abbas, Abdelmeguid, Yasmine, Ahmed, Yomna H.H.Z., Badib, Adham, Badreldin, Karim, Elkhashab, Yara, Heshmat, Hassan, Hussein, Amna, Mohamed Hussein, Amna Hussein, Ibrahim, Sandra, Shoman, Walaa, Yakout, Radwa M, Heinonen, Santtu, Angoulvant, François, Belot, Alexandre, Ouldali, Naïm, Beske, Florian, Heep, Axel, Masjosthusmann, Katja, Reiter, Karl, van den Heuvel, Ingeborg, von Both, Ulrich, Agrafiotou, Aikaterini, Antachopoulos, Charalampos, Charisi, Konstantina, Eleftheriou, Irini, Farmaki, Evangelia, Fotis, Lampros, Kafetzis, Dimitrios, Koletsi, Patra, Kourtesi, Katerina, Lampidi, Stavroula, Liakopoulou, Theodota, Maritsi, Despoina, Michailidou, Elisa, Milioudi, Maria, Mparmpounaki, Ioanna, Papadimitriou, Eleni, Papaevangelou, Vassiliki, Roilides, Emmanuel, Tsiatsiou, Olga, Tsolas, Georgios, Tsolia, Maria, Vantsi, Petrina, Banegas Pineda, Linda Yajeira, Borjas Aguilar, Karla Leversia, Cantillano Quintero, Edwin Mauricio, Ip, Patrick, Kwan, Mike Yat Wah, Kwok, Janette, Lau, Yu Lung, To, Kelvin, Wong, Joshua Sung Chih, David, Mate, Farkas, David, Kalcakosz, Szofia, Szekeres, Klaudia, Zsigmond, Borbala, Aslam, Nadeem, Luder, Anthony, Andreozzi, Laura, Bianco, Francesco, Bucciarelli, Valentina, Buonsenso, Danilo, Cimaz, Rolando, De Luca, Maia, Dellepiane, Rosa Maria, Fabi, Marianna, Filice, Emanuele, Lanari, Marcello, Lo Vecchio, Andrea, Mastrolia, Maria Vincenza, Mauro, Angela, Mazza, Angelo, Papa, Mario Virgilio, Romani, Lorenza, Scarano, Sara Maria, Simonini, Gabriele, Tipo, Vincenzo, Verdoni, Lucio, Macharia, Anne-Marie, Musiime, Grace, Reel, Bhupi, Wangai, Frederick, Pace, David, Torpiano, Paul, Anaya-Enriquez, Nancy, Carreon-Guerrero, Juan Manuel, Chacon-Cruz, Enrique, Cheung López, Mariana, Faugier Fuentes, Enrique, Fonseca Flores, Marisol, García-Domínguez, Miguel, Giron Vargas, Ana Luisa, Lopez-Delgado, Ivan, Lopez Hernández, Liliana, Menchaca Aguayo, Hector F., Montaño-Duron, Jesus Gilberto, Pérez-Gaxiola, Giordano, Ramos Tiñini, Pamela, Tostado-Morales, Edgardo, Valadez, Julio, Inchley, Christopher, Klevberg, Sjur, Knudsen, Per Kristian, Måseide, Per Helge, Carrera, Jose Manuel, Castaño, Elizabeth, Daza Timana, Carlos Alberto, De Leon, Tirza, Estripeaut, Dora, Levy, Jacqueline, Norero, Ximena, Record, Javier, Rojas-Bonilla, Magda, Wong, Mayra, Iramain, Ricardo, Hernandez, Roger, Huamán, Gian, Munaico, Manuel, Peralta, Carlos, Seminario, Diego, Zapata Yarlequé, Elmer Hans, Gadzinska, Justyna, Ludwikowska, Kamila, Mandziuk, Joanna, Okarska-Napierała, Magdalena, Alacheva, Zalina A., Alexeeva, Ekaterina, Ananin, Petr V., Antsupova, Margarita, Bakradze, Maya D., Berbenyuk, Anna, Bobkova, Polina, Borzakova, Svetlana, Chashchina, Irina L., El-Taravi, Yasmin, Fisenko, Andrey P., Gautier, Marina S., Glazyrina, Anastasia, Gorlenko, Cyrill, Grosheva, Mariia, Kiselev, Herman, Kondrikova, Elena, Korobyants, Evgeniya, Korsunskiy, Anatoliy A., Kovygina, Karina, Krasnaya, Ekaterina, Kurbanova, Seda, Kurdup, Maria K., Mamutova, Anna V., Mazankova, Lyudmila, Mitushin, Ilya L., Munblit, Daniel, Nargizyan, Anzhelika, Orlova, Yanina O., Osmanov, Ismail M., Polyakova, Anastasia S., Pushkareva, Anna, Romanova, Olga, Samitova, Elmira, Shvedova, Anastasia, Sologub, Anna, Iakovleva, Ekaterina, Tepaev, Rustem F., Tkacheva, Anna A., Yegiyan, Margarita, Yusupova, Valeriya, Zholobova, Elena, Grasa, Carlos Daniel, Epalza, Cristina, Lopez Segura, Nuria, Martinon-Torres, Federico, Melendo, Susana, Mendez-Echevarria, Ana, Mesa Guzmán, Juan Miguel, Palacios Argueta, Jorge Roberto, Rivero-Calle, Irene, Rivière, Jacques, Rodríguez-González, Moisés, Rojo, Pablo, Sanchez Manubens, Judith, Soler-Palacin, Pere, Soriano-Arandes, Antoni, Tagarro, Alfredo, Villaverde, Serena, Altman, Maria, Brodin, Petter, Horne, AnnaCarin, Palmblad, Karin, Brotschi, Barbara, Meyer Sauteur, Patrick, Pachlopnik Schmid, Jana, Prader, Seraina, Relly, Christa, Schlapbach, Luregn J., Seiler, Michelle, Strasser, Sophie, Trück, Johannes, Weber, Kathrin, Wütz, Daniela, Hamdan, Alaa, Melhem, Ibrahim, Moussa, Ahmed, Dunk, Joke, Ketharanathan, Naomi, Vermont, Clementien, Akyüz Özkan, Esra, Cetin, Benhur Sirvan, Erdeniz, Emine Hafize, Şahin, Irfan Oğuz, Borisova, Galina, Boyarchuk, Oksana, Boychenko, Lidiya, Boyko, Yaryna, Diudenko, Nadiia, Dyvonyak, Olha, Kasiyan, Olexandr, Katerynych, Kostiantyn, Kostyuchenko, Larysa, Mamenko, Marina, Melnyk, Kateryna, Miagka, Nelia, Nazarenko, Liliya, Nezgoda, Iryna, Rykova, Stanislava, Svyst, Olga, Teslenko, Maria, Trykosh, Mykola, Vasilenko, Nataliya, Volokha, Alla, Adams, Charlotte, Akomolafe, Toju, Al-Abadi, Eslam, Alders, Nele, Alifieraki, Styliani, Ansumanu, Hareef, Aston, Emily, Avram, Paula, Bamford, Alasdair, Banks, Millie, Basu Roy, Robin, Beattie, Thomas, Boleti, Olga, Bracken, Abbey, Broad, Jonathan, Cai, James, Carrol, Enitan D., Carter, Michael, Chandran, Anchit, Charlesworth, James, Chawla, Jaya, Cooper, Hannah, Cooray, Samantha, Davies, Patrick, Davis, Francesca, Drysdale, Simon B., Dzora, Ella, Emonts, Marieke, Evans, Ceri, Fidler, Katy, Foster, Caroline, Gong, Chen, Gongrun, Berin, Gonzalez, Carmen, Gorgun, Berin, Grandjean, Louis, Grant, Karlie, Guo, Jonathan, Hacohen, Yael, Hall, Jack, Hamid, Hytham K.S., Hassell, Jane, Hesketh, Christine, Hewlett, Jessica, Hnieno, Ahmad, Holt-Davis, Hannah, Hossain, Aleena, Hu, Shiying, Hudson, Lee D., Jheeta, Sharon, Johnson, Mae, Johnson, Sarah, Jyothish, Deepthi, Kampmann, Beate, Kavirayani, Akhila, Kelly, Deborah, Kirubakaran, Arangan, Kucera, Filip, Langer, Daniel, Lawson, George, Lees, Emily A, Lenihan, Rebecca, Lillie, Jon, Longbottom, Katherine, Lyall, Hermione, Mackdermott, Niamh, Maltby, Sarah, Mclelland, Thomas, McMahon, Anne-Marie, Miller, Danielle, Miranda, Mariana, Mirza, Luwaiza, Morrison, Zoe, Moshal, Karyn, Muller, Jennifer, Musuka, Phoebe, Myttaraki, Evangelia, Nadel, Simon, Nair, Sreedevi, Nuttall, Luke, Oremakinde, Oyinkansola, Osaghae, Daniella, Osman, Fatima, Ostrzewska, Anna, Paccagnella, Davide, Panthula, Mrinalini, Papachatzi, Eleni, Papadopoulou, Charalampia, Patel, Fahim, Patel, Harsita, Payne, Helen, Penner, Justin, Polandi, Shervin, Prendergast, Andrew J., Ramnarayan, Padmanabhan, Ranasinghe, Lasith, Ravichandran, Muthukumaran, Rhys-Evans, Sophie, Riordan, Andrew, Rodrigues, Charlene M.C., Roe, Lauren, Romaine, Sam, Schobi, Nina, Seddon, James, Shingadia, Delane, Sikdar, Oishi, Srivastava, Anand, Struik, Siske, Sun, Thomas, Tan, Rachel Wei, Taylor, Alice, Taylor, Amanda, Taylor, Andrew, Tran, Steven, Tsagkaris, Stavros, Tudor-Williams, Gareth, van den Berg, Sarah, van der Velden, Fabian, Ventilacion, Lyn, Wellman, Paul A., Withers Green, Joseph, Yanney, Michael P., Yeung, Shunmay, Badheka, Aditya, Badran, Sarah, Bailey, Dwight M., Burch, Anna Kathryn, Burns, Jane C., Cichon, Catherine, Cirks, Blake, Dallman, Michael D., Delany, Dennis R., Fairchok, Mary, Friedman, Samantha, Geracht, Jennifer, Langs-Barlow, Allison, Mann, Kelly, Padhye, Amruta, Quade, Alexis, Ramirez, Kacy Alyne, Rockett, John, Sayed, Imran Ali, Santos, Roberto P., Shahin, Amr A., Tremoulet, Adriana, Umaru, Samuel, Widener, Rebecca, Mujuru, Hilda Angela, Kandawasvika, Gwendoline, Channon-Wells, Samuel, Vito, Ortensia, McArdle, Andrew J, Seaby, Eleanor G, Shah, Priyen, Pazukhina, Ekaterina, Wilson, Clare, Broderick, Claire, D'Souza, Giselle, Keren, Ilana, Nijman, Ruud G, Carter, Michael J, De, Tisham, Hoggart, Clive, Whittaker, Elizabeth, Herberg, Jethro A, Kaforou, Myrsini, Cunnington, Aubrey J, Blyuss, Oleg, and Levin, Michael

Published
2023
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8. Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study

Author

Sawicka, Marta, BerdejSzczot, Elżbieta, Brzuszkiewicz, Sebastian, Buda, Piotr, Czajka, Alicja, Czech, Agnieszka, Czerwińska, Ewa, Figlerowicz, Magdalena, FirekPędras, Małgorzata, Gawlik, Aneta, Gowin, Ewelina, Izdebska, Olga, JanuszkiewiczLewandowska, Danuta, Kiepuszka, Justyna, Koczwara, Agnieszka, Koszałko, Danuta, KośmiderŻurawska, Magdalena, Książyk, Janusz, Kucińska, Beata, Kukawska, Martyna, Lackowska, Anita, Łapacz, Katarzyna, Maliszak, Agnieszka, Mania, Anna, Mańdziuk, Joanna, Mazur, Artur, Niszczota, Cezary, OpalińskaZielonka, Paulina, Rojewska, Katarzyna, RożnowskaWójtowicz, Anna, Siewert, Bartosz, Sobiczewska, Paulina, Stopyra, Lidia, StrobaŻelek, Agnieszka, StryczyńskaKazubska, Joanna, Sulik, Artur, Szatkowski, Tomasz, Szczepańska, Barbara, Szczukocki, Maciej, Szylo, Robert, Tyc, Filip, Wielgos, Katarzyna, Wołowska, Ewa, Wysocki, Jacek, Zacharzewska, Anna, Zaniew, Marcin, Zielińska, Marzena, ZiębaGlonek, Katarzyna, Toczyłowski, Kacper, Łasecka-Zadrożna, Joanna, Pałyga-Bysiecka, Ilona, Ludwikowska, Kamila Maria, Okarska-Napierała, Magdalena, Dudek, Natalia, Afelt, Aneta, Suski, Catherine, Kursa, Miron Bartosz, Jackowska, Teresa, Kuchar, Ernest, Szenborn, Leszek, and Mazur-Melewska, Katarzyna

Published
2022
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9. How international guidelines recommend treating children who have severe COVID‐19 or risk disease progression.

Author

Mańdziuk, Joanna, Kuchar, Ernest, and Okarska‐Napierała, Magdalena

Subjects
CHILD patients, OXYGEN therapy, DISEASE progression, BARICITINIB, MEDICAL personnel
Abstract

Aim: This study reviewed the current knowledge and guidelines on managing COVID‐19 in children and proposed a practical approach to drug treatment. Methods: We analysed international guidelines from four prominent scientific bodies on treating COVID‐19 in children. These were the UK National Institute for Health and Care Excellence, the American National Institutes of Health, the Infectious Diseases Society of America and the Australian National Clinical Evidence Taskforce COVID‐19. Results: Most paediatric patients with COVID‐19 only require symptomatic treatment. There was limited evidence on treatment recommendations for children with severe COVID‐19 or at risk of disease progression. However, several drugs are available for children and we have summarised the guidelines, in order to provide a concise, practical format for clinicians. All the guidelines agree that nirmatrelvir plus ritonavir or remdesivir can be used as prophylaxis for severe COVID‐19 in high‐risk patients. Remdesivir can also be used for severe COVID‐19 cases. Glucocorticosteroids are recommended, particularly in patients requiring oxygen therapy. Tocilizumab or baricitinib should be reserved for patients with progressive disease and/or signs of systemic inflammation. Conclusion: The guidelines provide useful advice and a degree of consensus on specific drug treatment for children with severe COVID‐19 or at risk of progression. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Renalase in Children with Glomerular Kidney Diseases

Author

Skrzypczyk, Piotr, Przychodzień, Joanna, Mizerska-Wasiak, Małgorzata, Kuźma-Mroczkowska, Elżbieta, Okarska-Napierała, Magdalena, Górska, Elżbieta, Stelmaszczyk-Emmel, Anna, Demkow, Urszula, Pańczyk-Tomaszewska, Małgorzata, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, Rezaei, Nima, Series editor, and Pokorski, Mieczyslaw, editor

Published
2017
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14. Pathogenesis, immunology, and immune-targeted management of the multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome (PIMS): EAACI Position Paper

Author

European Commission, Swiss National Science Foundation, European Academy of Allergy and Clinical Immunology, Innovation Fund Denmark, Instituto de Salud Carlos III, Feleszko, Wojciech, Okarska-Napierała, Magdalena, Buddingh, Emilie Pauline, Bloomfield, Marketa, Sediva, Anna, Bautista-Rodriguez, Carles, Brough, Helen A., Eigenmann, Philippe A., Eiwegger, Thomas, Eljaszewicz, Andrzej, Eyerich, Stefanie, Gomez-Casado, Cristina, Fraisse, Alain, Janda, Jozef, Jiménez Saiz, Rodrigo, Kallinich, Tilmann, Krohn, Inge Kortekaas, Mortz, Charlotte G., Riggioni, Carmen, Sastre, Joaquin, Sokolowska, Milena, Strzelczyk, Ziemowit, Untersmayr, Eva, Tramper-Stranders, Gerdien, European Commission, Swiss National Science Foundation, European Academy of Allergy and Clinical Immunology, Innovation Fund Denmark, Instituto de Salud Carlos III, Feleszko, Wojciech, Okarska-Napierała, Magdalena, Buddingh, Emilie Pauline, Bloomfield, Marketa, Sediva, Anna, Bautista-Rodriguez, Carles, Brough, Helen A., Eigenmann, Philippe A., Eiwegger, Thomas, Eljaszewicz, Andrzej, Eyerich, Stefanie, Gomez-Casado, Cristina, Fraisse, Alain, Janda, Jozef, Jiménez Saiz, Rodrigo, Kallinich, Tilmann, Krohn, Inge Kortekaas, Mortz, Charlotte G., Riggioni, Carmen, Sastre, Joaquin, Sokolowska, Milena, Strzelczyk, Ziemowit, Untersmayr, Eva, and Tramper-Stranders, Gerdien

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a rare, but severe complication of coronavirus disease 2019 (COVID-19). It develops approximately 4 weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and involves hyperinflammation with multisystem injury, commonly progressing to shock. The exact pathomechanism of MIS-C is not known, but immunological dysregulation leading to cytokine storm plays a central role. In response to the emergence of MIS-C, the European Academy of Allergy and Clinical Immunology (EAACI) established a task force (TF) within the Immunology Section in May 2021. With the use of an online Delphi process, TF formulated clinical statements regarding immunological background of MIS-C, diagnosis, treatment, follow-up, and the role of COVID-19 vaccinations. MIS-C case definition is broad, and diagnosis is made based on clinical presentation. The immunological mechanism leading to MIS-C is unclear and depends on activating multiple pathways leading to hyperinflammation. Current management of MIS-C relies on supportive care in combination with immunosuppressive and/or immunomodulatory agents. The most frequently used agents are systemic steroids and intravenous immunoglobulin. Despite good overall short-term outcome, MIS-C patients should be followed-up at regular intervals after discharge, focusing on cardiac disease, organ damage, and inflammatory activity. COVID-19 vaccination is a safe and effective measure to prevent MIS-C. In anticipation of further research, we propose a convenient and clinically practical algorithm for managing MIS-C developed by the Immunology Section of the EAACI.

Published
2023

16. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Author

Channon-Wells, Samuel, primary, Vito, Ortensia, additional, McArdle, Andrew J, additional, Seaby, Eleanor G, additional, Patel, Harsita, additional, Shah, Priyen, additional, Pazukhina, Ekaterina, additional, Wilson, Clare, additional, Broderick, Claire, additional, D'Souza, Giselle, additional, Keren, Ilana, additional, Nijman, Ruud G, additional, Tremoulet, Adriana, additional, Munblit, Daniel, additional, Ulloa-Gutierrez, Rolando, additional, Carter, Michael J, additional, Ramnarayan, Padmanabhan, additional, De, Tisham, additional, Hoggart, Clive, additional, Whittaker, Elizabeth, additional, Herberg, Jethro A, additional, Kaforou, Myrsini, additional, Cunnington, Aubrey J, additional, Blyuss, Oleg, additional, Levin, Michael, additional, Chouli, Mohamed, additional, Hamadouche, Nacera, additional, Ladj, Mohamed Samir, additional, Agrimbau Vázquez, Jorge, additional, Carmona, Rodrigo, additional, Collia, Adrian Gustavo, additional, Ellis, Alejandro, additional, Natta, Diego, additional, Pérez, Laura, additional, Rubiños, Mayra, additional, Veliz, Natalia, additional, Yori, Silvana, additional, Britton, Philip N., additional, Burgner, David P., additional, Carey, Emma, additional, Crawford, Nigel W., additional, Giuliano, Hayley, additional, McMinn, Alissa, additional, Wong, Shirley, additional, Wood, Nicholas, additional, Holter, Wolfgang, additional, Krainz, Matthias, additional, Ulreich, Raphael, additional, Zurl, Christoph, additional, Dehoorne, Joke, additional, Haerynck, Filomeen, additional, Hoste, Levi, additional, Schelstraete, Petra, additional, Vandekerckhove, Kristof, additional, Willems, Jef, additional, Almeida Farias, Camila Giuliana, additional, Almeida, Flávia Jacqueline, additional, Alves Leal, Izabel, additional, Araujo da Silva, André Ricardo, additional, Araujo e Silva, Anna Esther, additional, Barreiro, Sabrina T.A., additional, Bomfim Prado da Silva, Daniella Gregória, additional, Cervi, Maria Celia, additional, dos Santos Naja Cardoso, Mirian Viviane, additional, Henriques Teixeira, Cristiane, additional, Jarovsky, Daniel, additional, Martins Araujo, Julienne, additional, Naaman Berezin, Eitan, additional, Palazzi Sáfadi, Marco Aurélio, additional, Paternina-de la Ossa, Rolando Andres, additional, Souza Vieira, Cristina, additional, Dimitrova, Anna, additional, Ganeva, Margarita, additional, Stefanov, Stefan, additional, Telcharova-Mihaylovska, Albena, additional, Biggs, Catherine M., additional, Lopez, Alison, additional, Scuccimarri, Rosie, additional, Tan, Ryan, additional, Wasserman, Sam, additional, Withington, Davinia, additional, Ampuero, Camila, additional, Aravena, Javiera, additional, Bustos B, Raul, additional, Casanova, Daniel, additional, Cruces, Pablo, additional, Diaz, Franco, additional, García-Salum, Tamara, additional, Godoy, Loreto, additional, Medina, Rafael A., additional, Valenzuela Galaz, Gonzalo, additional, Camacho-Moreno, Germán, additional, Avila-Aguero, María L., additional, Brenes-Chacón, Helena, additional, Camacho-Badilla, Kattia, additional, Ivankovich-Escoto, Gabriela, additional, Naranjo-Zuniga, Gabriela, additional, Soriano-Fallas, Alejandra, additional, Yock-Corrales, Adriana, additional, Amer, Maysa Abbas, additional, Abdelmeguid, Yasmine, additional, Ahmed, Yomna H.H.Z., additional, Badib, Adham, additional, Badreldin, Karim, additional, Elkhashab, Yara, additional, Heshmat, Hassan, additional, Hussein, Amna, additional, Mohamed Hussein, Amna Hussein, additional, Ibrahim, Sandra, additional, Shoman, Walaa, additional, Yakout, Radwa M, additional, Heinonen, Santtu, additional, Angoulvant, François, additional, Belot, Alexandre, additional, Ouldali, Naïm, additional, Beske, Florian, additional, Heep, Axel, additional, Masjosthusmann, Katja, additional, Reiter, Karl, additional, van den Heuvel, Ingeborg, additional, von Both, Ulrich, additional, Agrafiotou, Aikaterini, additional, Antachopoulos, Charalampos, additional, Charisi, Konstantina, additional, Eleftheriou, Irini, additional, Farmaki, Evangelia, additional, Fotis, Lampros, additional, Kafetzis, Dimitrios, additional, Koletsi, Patra, additional, Kourtesi, Katerina, additional, Lampidi, Stavroula, additional, Liakopoulou, Theodota, additional, Maritsi, Despoina, additional, Michailidou, Elisa, additional, Milioudi, Maria, additional, Mparmpounaki, Ioanna, additional, Papadimitriou, Eleni, additional, Papaevangelou, Vassiliki, additional, Roilides, Emmanuel, additional, Tsiatsiou, Olga, additional, Tsolas, Georgios, additional, Tsolia, Maria, additional, Vantsi, Petrina, additional, Banegas Pineda, Linda Yajeira, additional, Borjas Aguilar, Karla Leversia, additional, Cantillano Quintero, Edwin Mauricio, additional, Ip, Patrick, additional, Kwan, Mike Yat Wah, additional, Kwok, Janette, additional, Lau, Yu Lung, additional, To, Kelvin, additional, Wong, Joshua Sung Chih, additional, David, Mate, additional, Farkas, David, additional, Kalcakosz, Szofia, additional, Szekeres, Klaudia, additional, Zsigmond, Borbala, additional, Aslam, Nadeem, additional, Luder, Anthony, additional, Andreozzi, Laura, additional, Bianco, Francesco, additional, Bucciarelli, Valentina, additional, Buonsenso, Danilo, additional, Cimaz, Rolando, additional, De Luca, Maia, additional, Dellepiane, Rosa Maria, additional, Fabi, Marianna, additional, Filice, Emanuele, additional, Lanari, Marcello, additional, Lo Vecchio, Andrea, additional, Mastrolia, Maria Vincenza, additional, Mauro, Angela, additional, Mazza, Angelo, additional, Papa, Mario Virgilio, additional, Romani, Lorenza, additional, Scarano, Sara Maria, additional, Simonini, Gabriele, additional, Tipo, Vincenzo, additional, Verdoni, Lucio, additional, Macharia, Anne-Marie, additional, Musiime, Grace, additional, Reel, Bhupi, additional, Wangai, Frederick, additional, Pace, David, additional, Torpiano, Paul, additional, Anaya-Enriquez, Nancy, additional, Carreon-Guerrero, Juan Manuel, additional, Chacon-Cruz, Enrique, additional, Cheung López, Mariana, additional, Faugier Fuentes, Enrique, additional, Fonseca Flores, Marisol, additional, García-Domínguez, Miguel, additional, Giron Vargas, Ana Luisa, additional, Lopez-Delgado, Ivan, additional, Lopez Hernández, Liliana, additional, Menchaca Aguayo, Hector F., additional, Montaño-Duron, Jesus Gilberto, additional, Pérez-Gaxiola, Giordano, additional, Ramos Tiñini, Pamela, additional, Tostado-Morales, Edgardo, additional, Valadez, Julio, additional, Inchley, Christopher, additional, Klevberg, Sjur, additional, Knudsen, Per Kristian, additional, Måseide, Per Helge, additional, Carrera, Jose Manuel, additional, Castaño, Elizabeth, additional, Daza Timana, Carlos Alberto, additional, De Leon, Tirza, additional, Estripeaut, Dora, additional, Levy, Jacqueline, additional, Norero, Ximena, additional, Record, Javier, additional, Rojas-Bonilla, Magda, additional, Wong, Mayra, additional, Iramain, Ricardo, additional, Hernandez, Roger, additional, Huamán, Gian, additional, Munaico, Manuel, additional, Peralta, Carlos, additional, Seminario, Diego, additional, Zapata Yarlequé, Elmer Hans, additional, Gadzinska, Justyna, additional, Ludwikowska, Kamila, additional, Mandziuk, Joanna, additional, Okarska-Napierała, Magdalena, additional, Alacheva, Zalina A., additional, Alexeeva, Ekaterina, additional, Ananin, Petr V., additional, Antsupova, Margarita, additional, Bakradze, Maya D., additional, Berbenyuk, Anna, additional, Bobkova, Polina, additional, Borzakova, Svetlana, additional, Chashchina, Irina L., additional, El-Taravi, Yasmin, additional, Fisenko, Andrey P., additional, Gautier, Marina S., additional, Glazyrina, Anastasia, additional, Gorlenko, Cyrill, additional, Grosheva, Mariia, additional, Kiselev, Herman, additional, Kondrikova, Elena, additional, Korobyants, Evgeniya, additional, Korsunskiy, Anatoliy A., additional, Kovygina, Karina, additional, Krasnaya, Ekaterina, additional, Kurbanova, Seda, additional, Kurdup, Maria K., additional, Mamutova, Anna V., additional, Mazankova, Lyudmila, additional, Mitushin, Ilya L., additional, Nargizyan, Anzhelika, additional, Orlova, Yanina O., additional, Osmanov, Ismail M., additional, Polyakova, Anastasia S., additional, Pushkareva, Anna, additional, Romanova, Olga, additional, Samitova, Elmira, additional, Shvedova, Anastasia, additional, Sologub, Anna, additional, Iakovleva, Ekaterina, additional, Tepaev, Rustem F., additional, Tkacheva, Anna A., additional, Yegiyan, Margarita, additional, Yusupova, Valeriya, additional, Zholobova, Elena, additional, Grasa, Carlos Daniel, additional, Epalza, Cristina, additional, Lopez Segura, Nuria, additional, Martinon-Torres, Federico, additional, Melendo, Susana, additional, Mendez-Echevarria, Ana, additional, Mesa Guzmán, Juan Miguel, additional, Palacios Argueta, Jorge Roberto, additional, Rivero-Calle, Irene, additional, Rivière, Jacques, additional, Rodríguez-González, Moisés, additional, Rojo, Pablo, additional, Sanchez Manubens, Judith, additional, Soler-Palacin, Pere, additional, Soriano-Arandes, Antoni, additional, Tagarro, Alfredo, additional, Villaverde, Serena, additional, Altman, Maria, additional, Brodin, Petter, additional, Horne, AnnaCarin, additional, Palmblad, Karin, additional, Brotschi, Barbara, additional, Meyer Sauteur, Patrick, additional, Pachlopnik Schmid, Jana, additional, Prader, Seraina, additional, Relly, Christa, additional, Schlapbach, Luregn J., additional, Seiler, Michelle, additional, Strasser, Sophie, additional, Trück, Johannes, additional, Weber, Kathrin, additional, Wütz, Daniela, additional, Hamdan, Alaa, additional, Melhem, Ibrahim, additional, Moussa, Ahmed, additional, Dunk, Joke, additional, Ketharanathan, Naomi, additional, Vermont, Clementien, additional, Akyüz Özkan, Esra, additional, Cetin, Benhur Sirvan, additional, Erdeniz, Emine Hafize, additional, Şahin, Irfan Oğuz, additional, Borisova, Galina, additional, Boyarchuk, Oksana, additional, Boychenko, Lidiya, additional, Boyko, Yaryna, additional, Diudenko, Nadiia, additional, Dyvonyak, Olha, additional, Kasiyan, Olexandr, additional, Katerynych, Kostiantyn, additional, Kostyuchenko, Larysa, additional, Mamenko, Marina, additional, Melnyk, Kateryna, additional, Miagka, Nelia, additional, Nazarenko, Liliya, additional, Nezgoda, Iryna, additional, Rykova, Stanislava, additional, Svyst, Olga, additional, Teslenko, Maria, additional, Trykosh, Mykola, additional, Vasilenko, Nataliya, additional, Volokha, Alla, additional, Adams, Charlotte, additional, Akomolafe, Toju, additional, Al-Abadi, Eslam, additional, Alders, Nele, additional, Alifieraki, Styliani, additional, Ansumanu, Hareef, additional, Aston, Emily, additional, Avram, Paula, additional, Bamford, Alasdair, additional, Banks, Millie, additional, Basu Roy, Robin, additional, Beattie, Thomas, additional, Boleti, Olga, additional, Bracken, Abbey, additional, Broad, Jonathan, additional, Cai, James, additional, Carrol, Enitan D., additional, Carter, Michael, additional, Chandran, Anchit, additional, Charlesworth, James, additional, Chawla, Jaya, additional, Cooper, Hannah, additional, Cooray, Samantha, additional, Davies, Patrick, additional, Davis, Francesca, additional, Drysdale, Simon B., additional, Dzora, Ella, additional, Emonts, Marieke, additional, Evans, Ceri, additional, Fidler, Katy, additional, Foster, Caroline, additional, Gong, Chen, additional, Gongrun, Berin, additional, Gonzalez, Carmen, additional, Gorgun, Berin, additional, Grandjean, Louis, additional, Grant, Karlie, additional, Guo, Jonathan, additional, Hacohen, Yael, additional, Hall, Jack, additional, Hamid, Hytham K.S., additional, Hassell, Jane, additional, Hesketh, Christine, additional, Hewlett, Jessica, additional, Hnieno, Ahmad, additional, Holt-Davis, Hannah, additional, Hossain, Aleena, additional, Hu, Shiying, additional, Hudson, Lee D., additional, Jheeta, Sharon, additional, Johnson, Mae, additional, Johnson, Sarah, additional, Jyothish, Deepthi, additional, Kampmann, Beate, additional, Kavirayani, Akhila, additional, Kelly, Deborah, additional, Kirubakaran, Arangan, additional, Kucera, Filip, additional, Langer, Daniel, additional, Lawson, George, additional, Lees, Emily A, additional, Lenihan, Rebecca, additional, Lillie, Jon, additional, Longbottom, Katherine, additional, Lyall, Hermione, additional, Mackdermott, Niamh, additional, Maltby, Sarah, additional, Mclelland, Thomas, additional, McMahon, Anne-Marie, additional, Miller, Danielle, additional, Miranda, Mariana, additional, Mirza, Luwaiza, additional, Morrison, Zoe, additional, Moshal, Karyn, additional, Muller, Jennifer, additional, Musuka, Phoebe, additional, Myttaraki, Evangelia, additional, Nadel, Simon, additional, Nair, Sreedevi, additional, Nuttall, Luke, additional, Oremakinde, Oyinkansola, additional, Osaghae, Daniella, additional, Osman, Fatima, additional, Ostrzewska, Anna, additional, Paccagnella, Davide, additional, Panthula, Mrinalini, additional, Papachatzi, Eleni, additional, Papadopoulou, Charalampia, additional, Patel, Fahim, additional, Payne, Helen, additional, Penner, Justin, additional, Polandi, Shervin, additional, Prendergast, Andrew J., additional, Ranasinghe, Lasith, additional, Ravichandran, Muthukumaran, additional, Rhys-Evans, Sophie, additional, Riordan, Andrew, additional, Rodrigues, Charlene M.C., additional, Roe, Lauren, additional, Romaine, Sam, additional, Schobi, Nina, additional, Seddon, James, additional, Shingadia, Delane, additional, Sikdar, Oishi, additional, Srivastava, Anand, additional, Struik, Siske, additional, Sun, Thomas, additional, Tan, Rachel Wei, additional, Taylor, Alice, additional, Taylor, Amanda, additional, Taylor, Andrew, additional, Tran, Steven, additional, Tsagkaris, Stavros, additional, Tudor-Williams, Gareth, additional, van den Berg, Sarah, additional, van der Velden, Fabian, additional, Ventilacion, Lyn, additional, Wellman, Paul A., additional, Withers Green, Joseph, additional, Yanney, Michael P., additional, Yeung, Shunmay, additional, Badheka, Aditya, additional, Badran, Sarah, additional, Bailey, Dwight M., additional, Burch, Anna Kathryn, additional, Burns, Jane C., additional, Cichon, Catherine, additional, Cirks, Blake, additional, Dallman, Michael D., additional, Delany, Dennis R., additional, Fairchok, Mary, additional, Friedman, Samantha, additional, Geracht, Jennifer, additional, Langs-Barlow, Allison, additional, Mann, Kelly, additional, Padhye, Amruta, additional, Quade, Alexis, additional, Ramirez, Kacy Alyne, additional, Rockett, John, additional, Sayed, Imran Ali, additional, Santos, Roberto P., additional, Shahin, Amr A., additional, Umaru, Samuel, additional, Widener, Rebecca, additional, Mujuru, Hilda Angela, additional, and Kandawasvika, Gwendoline, additional

Published
2023
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17. Pathogenesis, immunology, and immune-targeted management of the multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome (PIMS)

Author

Immunology Section and Working Group Infections of the EAACI, Feleszko, Wojciech, Okarska-Napierała, Magdalena, Buddingh, Emilie Pauline, Bloomfield, Marketa, Sediva, Anna, Bautista-Rodriguez, Carles, Brough, Helen A, Eigenmann, Philippe A, Eiwegger, Thomas, Eljaszewicz, Andrzej, Eyerich, Stefanie, Gomez-Casado, Cristina, Fraisse, Alain, Janda, Jozef, Jiménez-Saiz, Rodrigo, Kallinich, Tilmann, Krohn, Inge Kortekaas, Mortz, Charlotte G, Riggioni, Carmen, Sastre, Joaquin, Sokolowska, Milena, Strzelczyk, Ziemowit, Untersmayr, Eva, Tramper-Stranders, Gerdien, and Dermatology

Subjects
COVID-19 Vaccines, SARS-CoV-2, Immunology, Pediatrics, Perinatology and Child Health, Immunology and Allergy, Humans, COVID-19, Child, Systemic Inflammatory Response Syndrome/diagnosis
Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a rare, but severe complication of coronavirus disease 2019 (COVID-19). It develops approximately 4 weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and involves hyperinflammation with multisystem injury, commonly progressing to shock. The exact pathomechanism of MIS-C is not known, but immunological dysregulation leading to cytokine storm plays a central role. In response to the emergence of MIS-C, the European Academy of Allergy and Clinical Immunology (EAACI) established a task force (TF) within the Immunology Section in May 2021. With the use of an online Delphi process, TF formulated clinical statements regarding immunological background of MIS-C, diagnosis, treatment, follow-up, and the role of COVID-19 vaccinations. MIS-C case definition is broad, and diagnosis is made based on clinical presentation. The immunological mechanism leading to MIS-C is unclear and depends on activating multiple pathways leading to hyperinflammation. Current management of MIS-C relies on supportive care in combination with immunosuppressive and/or immunomodulatory agents. The most frequently used agents are systemic steroids and intravenous immunoglobulin. Despite good overall short-term outcome, MIS-C patients should be followed-up at regular intervals after discharge, focusing on cardiac disease, organ damage, and inflammatory activity. COVID-19 vaccination is a safe and effective measure to prevent MIS-C. In anticipation of further research, we propose a convenient and clinically practical algorithm for managing MIS-C developed by the Immunology Section of the EAACI.

Published
2023

18. Pathogenesis, immunology, and immune-targeted management of the multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome (PIMS): EAACI Position Paper

Author

Feleszko, Wojciech, Okarska‐Napierała, Magdalena, Buddingh, Emilie Pauline, et al, Sokolowska, Milena, and University of Zurich

Subjects
10183 Swiss Institute of Allergy and Asthma Research, Immunology, Immunology and Allergy, 610 Medicine & health, Perinatology and Child Health, Pediatrics
Published
2023
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19. EAACI statement on the pathogenesis, immunology, and immune-targeted management of the Multisystem Inflammatory Syndrome in Children (MIS-C) or Pediatric Inflammatory Multisystem Syndrome (PIMS).

Author

Feleszko, Wojciech, primary, Okarska-Napierała, Magdalena, additional, Buddingh, Emilie Pauline, additional, Bloomfield, Marketa, additional, Sediva, Anna, additional, Bautista-Rodriguez, Carles, additional, Brough, Helen, additional, Eigenmann, Philippe, additional, Eiwegger, Thomas, additional, Eljaszewicz, Andrzej, additional, Eyerich, Stefanie, additional, Gomez-Casado, Cristina, additional, Fraisse, Alain, additional, Janda, Jozef, additional, Jiménez-Saiz, Rodrigo, additional, Kallinich, Tilmann, additional, Krohn, Inge Kortekaas, additional, Mørtz, Charlotte, additional, RIGGIONI, CARMEN, additional, Sastre, Joaquin, additional, Sokolowska, Milena, additional, Strzelczyk, Ziemowit, additional, Untersmayr, Eva, additional, and Tramper, Gerdien, additional

Published
2022
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20. Analysis of 21 appendices from children with multisystem inflammatory syndrome compared to specimens of acute appendicitis – a new insight into MIS-C pathology

Author

Okarska-Napierała, Magdalena, primary, Woźniak, Weronika, additional, Mańdziuk, Joanna, additional, Ludwikowska, Kamila Maria, additional, Feleszko, Wojciech, additional, Grzybowski, Jakub, additional, Panczyk, Mariusz, additional, Berdej-Szczot, Elżbieta, additional, Zaryczański, Janusz, additional, Górnicka, Barbara, additional, Szenborn, Leszek, additional, and Kuchar, Ernest, additional

Published
2022
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21. Renalase in Children with Glomerular Kidney Diseases

Author

Skrzypczyk, Piotr, primary, Przychodzień, Joanna, additional, Mizerska-Wasiak, Małgorzata, additional, Kuźma-Mroczkowska, Elżbieta, additional, Okarska-Napierała, Magdalena, additional, Górska, Elżbieta, additional, Stelmaszczyk-Emmel, Anna, additional, Demkow, Urszula, additional, and Pańczyk-Tomaszewska, Małgorzata, additional

Published
2017
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22. A tendency to worse course of multisystem inflammatory syndrome in children with obesity: MultiOrgan Inflammatory Syndromes COVID-19 related study

Author

Gawlik, Aneta Monika, primary, Berdej-Szczot, Elżbieta, additional, Chmiel, Iga, additional, Lorek, Miłosz, additional, Antosz, Aleksandra, additional, Firek-Pędras, Małgorzata, additional, Szydłowski, Lesław, additional, Ludwikowska, Kamila Maria, additional, Okarska-Napierała, Magdalena, additional, Dudek, Natalia, additional, Piwoński, Krzysztof, additional, Afelt, Aneta, additional, Suski-Grabowski, Catherine, additional, Kursa, Miron Bartosz, additional, Kuchar, Ernest, additional, Szenborn, Leszek, additional, Jackowska, Teresa, additional, Peregud-Pogorzelski, Jarosław, additional, and Mazur, Artur, additional

Published
2022
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24. Use of broad-spectrum antibiotics in children diagnosed with multisystem inflammatory syndrome temporarily associated with SARS-CoV-2 infection in Poland: the MOIS-CoR study

Author

Toczyłowski, Kacper, primary, Łasecka-Zadrożna, Joanna, additional, Pałyga-Bysiecka, Ilona, additional, Ludwikowska, Kamila Maria, additional, Okarska-Napierała, Magdalena, additional, Dudek, Natalia, additional, Afelt, Aneta, additional, Suski, Catherine, additional, Kursa, Miron Bartosz, additional, Jackowska, Teresa, additional, Kuchar, Ernest, additional, Szenborn, Leszek, additional, Mazur-Melewska, Katarzyna, additional, Sawicka, Marta, additional, BerdejSzczot, Elżbieta, additional, Brzuszkiewicz, Sebastian, additional, Buda, Piotr, additional, Czajka, Alicja, additional, Czech, Agnieszka, additional, Czerwińska, Ewa, additional, Figlerowicz, Magdalena, additional, FirekPędras, Małgorzata, additional, Gawlik, Aneta, additional, Gowin, Ewelina, additional, Izdebska, Olga, additional, JanuszkiewiczLewandowska, Danuta, additional, Kiepuszka, Justyna, additional, Koczwara, Agnieszka, additional, Koszałko, Danuta, additional, KośmiderŻurawska, Magdalena, additional, Książyk, Janusz, additional, Kucińska, Beata, additional, Kukawska, Martyna, additional, Lackowska, Anita, additional, Łapacz, Katarzyna, additional, Maliszak, Agnieszka, additional, Mania, Anna, additional, Mańdziuk, Joanna, additional, Mazur, Artur, additional, Niszczota, Cezary, additional, OpalińskaZielonka, Paulina, additional, Rojewska, Katarzyna, additional, RożnowskaWójtowicz, Anna, additional, Siewert, Bartosz, additional, Sobiczewska, Paulina, additional, Stopyra, Lidia, additional, StrobaŻelek, Agnieszka, additional, StryczyńskaKazubska, Joanna, additional, Sulik, Artur, additional, Szatkowski, Tomasz, additional, Szczepańska, Barbara, additional, Szczukocki, Maciej, additional, Szylo, Robert, additional, Tyc, Filip, additional, Wielgos, Katarzyna, additional, Wołowska, Ewa, additional, Wysocki, Jacek, additional, Zacharzewska, Anna, additional, Zaniew, Marcin, additional, Zielińska, Marzena, additional, and ZiębaGlonek, Katarzyna, additional

Published
2022
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25. Wpływ przebiegającego z gorączką zakażenia układu moczowego u dzieci na poszerzenie dróg moczowych w badaniu ultrasonograficznym.

Author

Okarska-Napierała, Magdalena, Karpierz, Katarzyna, Bombiński, Przemysław, Majcher, Piotr, Waszkowski, Adam, and Kuchar, Ernest Piotr

Subjects
URINARY organs, URINARY tract infections, INVASIVE diagnosis, CONGENITAL disorders, C-reactive protein, BLADDER
Abstract

Copyright of Paediatrics & Family Medicine / Pediatria i Medycyna Rodzinna is the property of Medical Communications Sp. z o.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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31. Multisystem inflammatory syndrome in European White children – study of 274 cases

Author

Ludwikowska, Kamila Maria, primary, Okarska-Napierała, Magdalena, additional, Dudek, Natalia, additional, Tracewski, Paweł, additional, Kusa, Jacek, additional, Piwoński, Krzysztof, additional, Afelt, Aneta, additional, Cysewski, Dominik, additional, Biela, Mateusz, additional, Werner, Bożena, additional, Jackowska, Teresa, additional, Suski, Catherine, additional, Kursa, Miron Bartosz, additional, Kuchar, Ernest, additional, and Szenborn, Leszek, additional

Published
2021
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32. Association Between rs12037447, rs146732504, rs151078858, rs55723436, and rs6094136 Polymorphisms and Kawasaki Disease in the Population of Polish Children

Author

Buda, Piotr, primary, Chyb, Maciej, additional, Smorczewska-Kiljan, Anna, additional, Wieteska-Klimczak, Anna, additional, Paczesna, Agata, additional, Kowalczyk-Domagała, Monika, additional, Okarska-Napierała, Magdalena, additional, Sobalska-Kwapis, Marta, additional, Grochowalski, Łukasz, additional, Słomka, Marcin, additional, Sitek, Aneta, additional, Ksia̧żyk, Janusz, additional, and Strapagiel, Dominik, additional

Published
2021
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34. Approach to a child with Multisystem Inflammatory Syndrome associated with COVID19. Recommendations by the Polish Paediatric Society Expert Group. Update – February 2021

Author

Okarska-Napierała, Magdalena, primary, Ludwikowska, Kamila, additional, Jackowska, Teresa, additional, Książyk, Janusz, additional, Buda, Piotr, additional, Mazur, Artur, additional, Szenborn, Leszek, additional, Werner, Bożena, additional, Wysocki, Jacek, additional, and Kuchar, Ernest, additional

Published
2021
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36. Pediatric Inflammatory Multisystem Syndrome (PIMS) Did Occur in Poland during Months with Low COVID-19 Prevalence. Preliminary Results of a Nationwide Register.

Author

Okarska-Napierała, Magdalena, primary, Ludwikowska, Kamila, additional, Szenborn, Leszek, additional, Dudek, Natalia, additional, Mania, Anna, additional, Buda, Piotr, additional, Książyk, Janusz, additional, Mazur-Malewska, Katarzyna, additional, Figlerowicz, Magdalena, additional, Szczukocki, Maciej, additional, Kucińska, Beata, additional, Werner, Bożena, additional, Stopyra, Lidia, additional, Czech, Agnieszka, additional, Berdej-Szczot, Elżbieta, additional, Gawlik, Aneta, additional, Opalińska, Paulina, additional, Mazur, Artur, additional, Januszkiewicz-Lewandowska, Danuta, additional, Niszczota, Cezary, additional, Jackowska, Teresa, additional, Wysocki, Jacek, additional, Tracewski, Paweł, additional, Kusa, Jacek, additional, Potocka, Paulina, additional, Sulik, Artur, additional, Ziora, Katarzyna, additional, Krakowczyk, Helena, additional, Wodniak, Aleksandra, additional, Zaryczański, Janusz, additional, Żakiewicz-Cepak, Alicja, additional, Jarocka-Cyrta, Elżbieta, additional, Koczwara, Agnieszka, additional, Prusek-Dudkiewicz, Anna, additional, Zbucka-Jachowska, Ewa, additional, Langer-Wójcik, Sabina, additional, Kołodziej, Elżbieta, additional, and Kuchar, Ernest, additional

Published
2020
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37. Pneumococcal carriage in unvaccinated children at the time of vaccine implementation into the national immunization program in Poland.

Author

Wróbel-Pawelczyk, Izabela, Ronkiewicz, Patrycja, Wanke-Rytt, Monika, Rykowska, Dominika, Górska-Kot, Aneta, Włodkowska, Katarzyna, Topczewska-Cabanek, Agnieszka, Jackowska, Teresa, Chruszcz, Joanna, Marchut, Walentyna, Mastalerz-Migas, Agnieszka, Korzeniewski, Krzysztof, GIL Study Team, Gastoł, Karolina, Gromek, Marta, Jankowska-Sasin, Katarzyna, Karpierz, Katarzyna, Okarska-Napierała, Magdalena, Pokorna-Kałwak, Dagmara, and Polit, Agata

Subjects
VACCINATION of children, VACCINATION, VACCINATION status, DAY care centers, IMMUNIZATION
Abstract

We investigated pneumococcal carriage among unvaccinated children under five years of age at a time when the conjugate polysaccharide vaccine (PCV) was introduced in Poland into the national immunization program (NIP). Paired nasopharyngeal swab (NPS) and saliva samples collected between 2016 and 2020 from n = 394 children were tested with conventional culture and using qPCR. The carriage rate detected by culture was 25.4% (97 of 394), by qPCR 39.1% (155 of 394), and 40.1% (158 of 394) overall. The risk of carriage was significantly elevated among day care center attendees, and during autumn/winter months. Among isolates cultured, the most common serotypes were: 23A, 6B, 15BC, 10A, 11A. The coverage of PCV10 and PCV13 was 23.2% (23 of 99) and 26.3% (26 of 99), respectively. Application of qPCR lead to detection of 168 serotype carriage events, with serogroups 15, 6, 9 and serotype 23A most commonly detected. Although the highest number of carriers was identified by testing NPS with qPCR, saliva significantly contributed to the overall number of detected carriers. Co-carriage of multiple serotypes was detected in 25.3% (40 of 158) of carriers. The results of this study represent a baseline for the future surveillance of effects of pneumococcal vaccines in NIP in Poland. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Approach to a child with Multisystem Inflammatory Syndrome associated with COVID-19. Recommendations by the Polish Paediatric Society Expert Group. Update - February 2021.

Author

Okarska-Napierała, Magdalena, Ludwikowska, Kamila, Jackowska, Teresa, Książyk, Janusz, Buda, Piotr, Mazur, Artur, Szenborn, Leszek, Werner, Bożena, Wysocki, Jacek, and Kuchar, Ernest

Subjects
MULTISYSTEM inflammatory syndrome in children, COVID-19 pandemic, HEALTH of young adults, BIOMARKERS, ARRHYTHMIA
Abstract

Multisystem Inflammatory Syndrome in Children (MIS-C) is a new clinical entity occurring in children and young adults, which is associated with the SARS-CoV-2 infection. The first cases of MIS-C were diagnosed in Poland in May 2020. Since October 2020, a significant increase in the incidence of this new disease has been observed in Poland, reflecting the increased incidence of COVID-19 in the paediatric population. MIS-C develops as a result of dysregulation of the immune system occurring 4 weeks after the SARS-CoV-2 infection. Diagnosis is based on the following criteria: a set of clinical features (including fever and signs of multiple organ damage) and elevated inflammatory markers, with exclusion of other causes. The most common complications involve the cardiovascular system: acute myocardial damage with reduced left ventricular ejection fraction, shock, and coronary artery abnormalities and arrhythmias. Mortality in Western Europe and the United States is around 1-2%. Appropriate management, including vital function support and immunomodulatory treatment, allows for a quick recovery in the vast majority of patients. This document is an updated guideline for the diagnostic and therapeutic management of children with suspected MIS-C in Poland. The most important changes concern treatment, steroid therapy, and antiplatelet therapy in particular. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Pęcherzykowa wysypka u 5-letniego chłopca z dusznością.

Author

Okarska-Napierała, Magdalena, Tylewicz, Aleksandra, Guzik, Wioletta, and Kuchar, Ernest

Subjects
RESPIRATORY infections, STEVENS-Johnson Syndrome, MYCOPLASMA pneumoniae, TOXIC epidermal necrolysis, ERYTHEMA multiforme, COMMUNITY-acquired pneumonia
Abstract

Copyright of Paediatrics & Family Medicine / Pediatria i Medycyna Rodzinna is the property of Medical Communications Sp. z o.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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43. Nietypowy przebieg zakażenia wirusem ospy wietrznej i półpaśca u dziecka z ostrą białaczką limfoblastyczną.

Author

Okarska-Napierała, Magdalena, Albrecht, Katarzyna, Kawa, Justyna, and Kuchar, Ernest

Subjects
JUVENILE diseases, COMMUNICABLE diseases, CHICKENPOX, INTRAVENOUS therapy, IMMUNOCOMPROMISED patients, SKIN tests, LYMPHOBLASTIC leukemia
Abstract

Copyright of Paediatrics & Family Medicine / Pediatria i Medycyna Rodzinna is the property of Medical Communications Sp. z o.o. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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46. Pediatric Inflammatory Multisystem Syndrome (PIMS) Did Occur in Poland during Months with Low COVID-19 Prevalence, Preliminary Results of a Nationwide Register.

Author

Okarska-Napierała, Magdalena, Ludwikowska, Kamila M., Szenborn, Leszek, Dudek, Natalia, Mania, Anna, Buda, Piotr, Książyk, Janusz, Mazur-Malewska, Katarzyna, Figlerowicz, Magdalena, Szczukocki, Maciej, Kucińska, Beata, Werner, Bożena, Stopyra, Lidia, Czech, Agnieszka, Berdej-Szczot, Elżbieta, Gawlik, Aneta, Opalińska, Paulina, Mazur, Artur, Januszkiewicz-Lewandowska, Danuta, and Niszczota, Cezary

Subjects
*COVID-19, *COVID-19 pandemic, *COVID-19 testing, *SYNDROMES, *MUCOCUTANEOUS lymph node syndrome, *SARS-CoV-2
Abstract

Pediatric inflammatory multisystem syndrome (PIMS) is a new entity in children, likely associated with previous coronavirus disease 19 (COVID-19) infection. Most of the reports about PIMS come from countries particularly hit by the COVID-19 pandemic. Our aim was to investigate the nature of inflammatory syndromes in Poland (country with low COVID-19 prevalence) and to perceive the emergence of PIMS in our country. On 25 May 2020, we launched a nationwide survey of inflammatory syndromes in children for retrospective (since 4 March 2020) and prospective data collection. Up to 28 July, 39 reported children met the inclusion criteria. We stratified them according to age (<5 and ≥ 5 years old) and COVID-19 status. The majority of children had clinical and laboratory features of Kawasaki disease, probably non-associated with COVID-19. However, children ≥5 years of age had PIMS characteristics, and nine children had COVID-19 confirmation. This is, to our knowledge, the first report of the PIMS register from a country with a low COVID-19 prevalence, and it proves that PIMS may emerge in any area involved in the COVID-19 pandemic. In a context of limited COVID-19 testing availability, other risk factors of PIMS, e.g., older age, should be considered in the differential diagnosis of inflammatory syndromes in children. [ABSTRACT FROM AUTHOR]

Published
2020
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47. FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms.

Author

Uittenbogaard P, Netea SA, Tanck MWT, Geissler J, Buda P, Kowalczyk-Domagała M, Okarska-Napierała M, van Stijn D, Tacke CE, Burgner DP, Shimizu C, Burns JC, Kuipers IM, Kuijpers TW, and Nagelkerke SQ

Subjects
Humans, Male, Female, Child, Preschool, Drug Resistance genetics, Child, Infant, Case-Control Studies, DNA Copy Number Variations, Mucocutaneous Lymph Node Syndrome genetics, Mucocutaneous Lymph Node Syndrome drug therapy, Receptors, IgG genetics, Immunoglobulins, Intravenous therapeutic use, Genetic Predisposition to Disease, Coronary Aneurysm genetics, Coronary Aneurysm etiology, Polymorphism, Single Nucleotide
Abstract

Introduction: Kawasaki disease (KD) is a pediatric vasculitis that can result in coronary artery aneurysm (CAA) formation, which is a dangerous complication. Treatment with intravenous immunoglobulin (IVIg) significantly decreases the risk of CAA, possibly through competitive binding to Fc-gamma receptors (Fc γ Rs), which reduces the binding of pathological immune complexes. However, ~20% of children have recrudescence of fever and have an increased risk of CAA. Therefore, we aimed to identify genetic markers at the FCGR2/3 locus associated with susceptibility to KD, IVIg resistance, or CAA., Materials and Methods: We investigated the association of single-nucleotide polymorphisms (SNPs) and copy number variations (CNVs) at the FCGR2/3 locus with KD susceptibility, IVIg resistance, and CAA risk using a family-based test (KD susceptibility) and case-control analyses (IVIg resistance and CAA risk) in different cohorts, adding up to a total of 1,167 KD cases. We performed a meta-analysis on IVIg resistance and CAA risk including all cohorts supplemented by previous studies identified through a systematic search., Results: FCGR2A- p.166His was confirmed to be strongly associated with KD susceptibility (Z = 3.17, p = 0.0015). In case-control analyses, all of the investigated genetic variations at the FCGR2/3 locus were generally not associated with IVIg resistance or with CAA risk, apart from a possible association in a Polish cohort for the FCGR3B- NA2 haplotype (OR = 2.15, 95% CI = 1.15-4.01, p = 0.02). Meta-analyses of all available cohorts revealed no significant associations of the FCGR2/3 locus with IVIg resistance or CAA risk., Discussion: FCGR2/3 polymorphisms are associated with susceptibility to KD but not with IVIg resistance and CAA formation. Currently known genetic variations at the FCGR2/3 locus are not useful in prediction models for IVIg resistance or CAA risk., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Uittenbogaard, Netea, Tanck, Geissler, Buda, Kowalczyk-Domagała, Okarska-Napierała, van Stijn, Tacke and US Kawasaki Disease Genetics Consortium, Burgner, Shimizu, Burns, Kuipers, Kuijpers and Nagelkerke.)

Published
2024
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48. Serum Klotho is correlated to cardiovascular complications of chronic kidney disease in children.

Author

Okarska-Napierała M, Skrzypczyk P, Pietrzak R, Stelmaszczyk-Emmel A, Górska E, Werner B, and Pańczyk-Tomaszewska M

Subjects
Case-Control Studies, Child, Fibroblast Growth Factor-23, Fibroblast Growth Factors blood, Humans, Hypertrophy, Left Ventricular epidemiology, Hypertrophy, Left Ventricular etiology, Klotho Proteins, Vascular Stiffness physiology, Blood Pressure physiology, Glucuronidase blood, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic epidemiology
Abstract

Aim: Aim of the study was to investigate soluble Klotho (sKl), fibroblast growth factor 23 (FGF23) concentrations, and their correlations with cardiovascular complications in children with CKD., Materials and Methods: 38 children with CKD stages 2 - 5 were compared to 38 healthy controls in terms of: plasma FGF23, serum sKl, peripheral and central blood pressure, arterial stiffness (pulse wave velocity - (PWV)), carotid intima media thickness (cIMT), left ventricular mass index (LVMI), and diastolic function. Correlations between FGF23, sKl, and cardiovascular parameters were investigated., Results: The CKD group was characterized by higher FGF23, lower sKl concentrations, higher peripheral and central blood pressure, arterial stiffness, cIMT, left ventricular mass index, and decreased E/A ratio compared to the control group. In CKD children, sKl correlated negatively with diastolic blood pressure (DBP), mean arterial pressure (MAP), central systolic, diastolic, and mean blood pressure, PWV, and LVMI. In multivariate analysis, higher sKl was a significant predictor of lower peripheral and central DBP and lower LVMI and E/A, whereas higher FGF23 was a predictor of higher of LVMI., Conclusion: (1) In children with CKD, decreased sKl might be a marker of elevated central blood pressure. (2) Both sKl decrease and FGF23 increase could possibly contribute to left ventricular hypertrophy in this group of patients.

Published
2020
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49. Carotid intima-media thickness in children with idiopathic nephrotic syndrome: A single center cross-sectional study
.

Author

Skrzypczyk P, Kuźma-Mroczkowska E, Kułagowska J, Brzewski M, Okarska-Napierała M, and Pańczyk-Tomaszewska M

Subjects
Adolescent, Anti-Inflammatory Agents administration & dosage, Arterial Pressure, Atherosclerosis diagnostic imaging, Atherosclerosis etiology, Body Mass Index, Case-Control Studies, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Hypertension physiopathology, Male, Nephrotic Syndrome drug therapy, Prednisone administration & dosage, Recurrence, Retrospective Studies, Risk Factors, Time Factors, Carotid Artery, Common diagnostic imaging, Carotid Intima-Media Thickness, Hypertension complications, Nephrotic Syndrome complications
Abstract

Aim: Our aim was to assess common carotid artery intima-media thickness (cIMT) in children with idiopathic nephrotic syndrome (INS) and to find relation between cIMT and clinical and biochemical parameters in these patients., Materials and Methods: In 50 children with INS we retrospectively evaluated: cIMT ((mm) and Z-score) and selected clinical and biochemical parameters. The control group consisted of 20 healthy children aged 9.46 ± 2.29 years., Results: Children with INS had higher cIMT (0.45 ± 0.05 vs. 0.40 ± 0.05 (mm), p = 0.0002) and cIMT Z-score (1.72 ± 1.01 vs. 0.43 ± 1.01, p < 0.0001) than the control group. In the INS group, children with arterial hypertension had significantly higher cIMT (p = 0.0148) than normotensive children. In 50 children, with INS we found correlations between cIMT and disease duration (r = 0.40, p = 0.0040), number of INS relapses (r = 0.51, p< 0.0001), cumulative prednisone dose (r = 0.45, p = 0.0010), and BMI (r = 0.35, p = 0.0120); whereas, cIMT Z-score correlated only with the number of INS relapses (r = 0.41, p = 0.0160) and cumulative prednisone dose (r = 0.36, p = 0.0362). We found no relation between cIMT and response to corticosteroids, treatment used, and biochemical parameters., Conclusion: 1. Idiopathic nephrotic syndrome predisposes to atherosclerotic lesions in affected children. 2. The severity of atherosclerotic lesions is dependent mainly on the number of INS relapses, but disease vintage, cumulative steroid dose, body mass index, and presence of arterial hypertension may also be predisposing factors.
.

Published
2019
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