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1. More than smell – COVID-19 is associated with severe impairment of smell, taste, and chemesthesis

Author

Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G, Niv, Masha Y, Kelly, Christine E, Bakke, Alyssa J, Cooper, Keiland W, Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y, Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B, Gerkin, Richard C, Domínguez, Paloma Rohlfs, Albayay, Javier, Farruggia, Michael C, Bhutani, Surabhi, Fjaeldstad, Alexander W, Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R, Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A, Lim, Juyun, Whitcroft, KL, Colquitt, Lauren R, Ferdenzi, Camille, Brindha, Evelyn V, Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M, Fiorucci, Sébastien, Philpott, Carl M, Smith, Barry C, Lundström, Johan N, Mucignat, Carla, Parker, Jane K, van den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S, Heinbockel, Thomas, Shields, Vonnie DC, Faraji, Farhoud, Santamaría, Enrique, Fredborg, William EA, Morini, Gabriella, Olofsson, Jonas K, Jalessi, Maryam, Karni, Noam, D’Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M, Alwashahi, Mohammed K, Welge-Lüssen, Antje, Freiherr, Jessica, de Groot, Jasper HB, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W, Reed, Danielle R, Hummel, Thomas, Munger, Steven D, Hayes, John E, Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H, Voznessenskaya, Vera V, Chen, Jingguo, Sell, Elizabeth A, and Walsh-Messinger, Julie

Subjects
Neurosciences, Dental/Oral and Craniofacial Disease, Clinical Research, Adult, Aged, Betacoronavirus, COVID-19, Coronavirus Infections, Female, Humans, Male, Middle Aged, Olfaction Disorders, Pandemics, Pneumonia, Viral, SARS-CoV-2, Self Report, Smell, Somatosensory Disorders, Surveys and Questionnaires, Taste, Taste Disorders, Young Adult, head and neck surgery, olfaction, somatosensation, GCCR Group Author, Biological Sciences, Neurology & Neurosurgery
Abstract

Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± standard deviation), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

Published
2020

3. An olfactory self-test effectively screens for COVID-19

Author

Snitz, Kobi, Honigstein, Danielle, Weissgross, Reut, Ravia, Aharon, Mishor, Eva, Perl, Ofer, Karagach, Shiri, Medhanie, Abebe, Harel, Nir, Shushan, Sagit, Roth, Yehudah, Iravani, Behzad, Arshamian, Artin, Ernst, Gernot, Okamoto, Masako, Poo, Cindy, Bonacchi, Niccolò, Mainen, Zachary, Monteleone, Erminio, Dinnella, Caterina, Spinelli, Sara, Mariño-Sánchez, Franklin, Ferdenzi, Camille, Smeets, Monique, Touhara, Kazushige, Bensafi, Moustafa, Hummel, Thomas, Lundström, Johan N., and Sobel, Noam

Published
2022
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4. Brief Report: Odour Awareness in Young Children with Autism Spectrum Disorders

Author

Kumazaki, Hirokazu, Okamoto, Masako, Yoshimura, Yuko, Ikeda, Takashi, Hasegawa, Chiaki, Saito, Daisuke N., Iwanaga, Ryoichiro, Tomiyama, Sara, An, Kyung-min, Minabe, Yoshio, and Kikuchi, Mitsuru

Abstract

The elucidation of odour awareness in children with autism spectrum disorders (ASD) is important. We compared the odour awareness of young children with ASD with those of typical development (TD) children using the Children's Olfactory Behavior in Everyday Life (COBEL) questionnaire, which is a self-report measure that mainly assesses odour awareness. Forty-five young boys (aged 5-6 years), including 20 children with ASD and 25 TD children, participated in this study. The total COBEL score of the young children with ASD was lower than that of the TD children (p < 0.01). Moreover, the total COBEL score was significantly correlated with the total VABS II score (p < 0.05). Our results improve understanding of the odour awareness in children with ASD.

Published
2020
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6. Brief Report: Odour Awareness in Young Children with Autism Spectrum Disorders

Author

Kumazaki, Hirokazu, Okamoto, Masako, Yoshimura, Yuko, Ikeda, Takashi, Hasegawa, Chiaki, Saito, Daisuke N., and Iwanaga, Ryoichiro

Subjects
Pervasive developmental disorders -- Development and progression -- Diagnosis, Odors -- Appreciation -- Usage, Developmentally disabled children -- Beliefs, opinions and attitudes -- Evaluation -- Appreciation, Health
Abstract

The elucidation of odour awareness in children with autism spectrum disorders (ASD) is important. We compared the odour awareness of young children with ASD with those of typical development (TD) children using the Children's Olfactory Behavior in Everyday Life (COBEL) questionnaire, which is a self-report measure that mainly assesses odour awareness. Forty-five young boys (aged 5-6 years), including 20 children with ASD and 25 TD children, participated in this study. The total COBEL score of the young children with ASD was lower than that of the TD children (p < 0.01). Moreover, the total COBEL score was significantly correlated with the total VABS II score (p < 0.05). Our results improve understanding of the odour awareness in children with ASD., Author(s): Hirokazu Kumazaki [sup.1] , Masako Okamoto [sup.2] , Yuko Yoshimura [sup.1] , Takashi Ikeda [sup.1] , Chiaki Hasegawa [sup.1] , Daisuke N. Saito [sup.1] , Ryoichiro Iwanaga [sup.3] , [...]

Published
2020
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9. Learners' Self-evaluation of Rubric in the Practice of General Education in Informatics: Focusing on the Online Class Experience and the Difference in Academic Fields

Author

Sakai, Hiroyuki, Okamoto, Masako, and Kita, Hajime

Subjects
online education, general informatics education, 一般情報教育, 演習, rubric, ルーブリック, self-evaluation, practice class, 自己評価, オンライン授業
Abstract

本稿では，2020年度後期に開講した一般情報教育の演習科目において，受講者に対して実施した本科目のルーブリックの自己評価の結果を用いて受講前後の比較および前年度との比較を行い，後期の授業を通じた受講者の知識やスキルの変化を検証した．また，文系学部学生を対象に前期に開講された科目の結果との比較を行い理系・文系の分野の違いやオンライン授業の経験の有無について考察を行った．その結果，2020年度後期の授業実践において，受講前後のルーブリックの自己評価の得点が有意に増加したこと，前年度の結果との比較において受講後の得点が向上したことを確認した．また，前年度との結果の比較において，受講前後における各項目の得点の差異がオンライン授業への移行やその経験が得点の変化に寄与している可能性が示唆された．さらに，2020年度の前期と後期の結果の比較において，ルーブリックの各項目の受講前後の得点および得点の伸びの差について，オンライン授業の受講の有無や文系・理系の分野の違いが得点に影響を与える可能性が示唆された．, This research reports the improvement in learners' knowledge and skills through the practical course of basic informatics using the rubric. The learners' self-evaluation responses were collected for pre-and-post course in the fall semester of 2020. Academic fields and online class experience were discussed by comparing the results of the classes in 2019 with those of different target learners in the spring semester of 2020. Consequently, the authors confirmed that the average self-evaluation score significantly increased after the coursework during the fall semester of 2020. Moreover, the average score increased compared to the previous year's classes, which were conducted face-to-face. Compared to the results in 2019, the score improvement in 2020 might have been caused by the online class experience in the fall semester. Compared to the spring semester, the results for each rubric item suggested that the online class experience and the difference in the academic field might have affected the average score of self-assessment.

Published
2022

10. A Practice and Consideration of Online Class for Computer Programming in COVID-19

Author

Okamoto, Masako

Subjects
初学者, online education, プログラミング, 演習, コロナ禍, COVID-19, practice class, programming, novices, オンライン授業
Abstract

京都大学では，2020年3月，コロナ禍における対策として，ほとんどすべての対面授業をオンライン受講できるよう対策するとの方針を示した．本稿では，こうした状況下において実施した演習型プログラミング授業について，その実践例を報告するとともに，2019年に実施した従来型の対面授業と比較し，演習型授業のオンライン化における課題や問題点などについて考察した．その結果，オンライン授業では，授業の前半でつまずく受講者が多く見られたが，授業の後半では課題のプログラムを完成することができた割合が高かった．オンライン授業では，受講者が授業時間内にチャットで積極的に質問して，個々の疑問点を解消していたことが推察された．一方，対面授業では，授業の後半でつまずく受講者が多く見られており，授業中に質問しなかった（できなかった）受講生がいた可能性が浮かび上がった．, Due to the need to prevent the spread of the COVID-19 in March 2020, Kyoto University has been requested to offer online classes. Therefore, it has become necessary to shift from face-to-face classes to online classes. In this paper, a practical example of programming class is reported. Additionally, in this study, problems and issues in online classes are discussed by comparing with previous face-to-face classes in 2019. As a result, in the online class, many students failed in the first half of the class, but a high percentage of them were able to complete the assigned program in the second half of the class. It was assumed that the students actively asked questions via chat during the class session to resolve their individual issues. On the other hand, in the face-to-face class, many students appeared to falter in the latter half of the class, suggesting the possibility that some students did not (or could not) ask questions during the class.

Published
2022

14. Reinforcement Learning Atlas

Author

Tyszka, Julian, Pauli, Wolfgang, Nili, Amanda, and Okamoto, Masako

Subjects
education
Abstract

An in vivo atlas of human subcortical nuclei involved in reinforcement learning. Based on a midspace template derived from Human Connectome Project structural MRI.

Published
2022
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19. Mere end lugtesans - COVID-19 er associeret med svær påvirkning af lugtesansen, smagssansen og mundfølelsen

Author

Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G, Niv, Masha Y, Kelly, Christine E, Bakke, Alyssa J, Cooper, Keiland W, Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y, Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B, Gerkin, Richard C, Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C, Bhutani, Surabhi, Fjaeldstad, Alexander W, Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R, Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A, Lim, Juyun, Whitcroft, Katherine L, Colquitt, Lauren R, Ferdenzi, Camille, Brindha, Evelyn V, Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M, Fiorucci, Sébastien, Philpott, Carl M, Smith, Barry C, Lundström, Johan N, Mucignat, Carla, Parker, Jane K, van den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S, Heinbockel, Thomas, Shields, Vonnie D C, Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E A, Morini, Gabriella, Olofsson, Jonas K, Jalessi, Maryam, Karni, Noam, D’Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M, Alwashahi, Mohammed K, Welge-Lüssen, Antje, Freiherr, Jessica, de Groot, Jasper H B, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W, Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H, Voznessenskaya, Vera V, Chen, Jingguo, Sell, Elizabeth A, Walsh-Messinger, Julie, Archer, Nicholas S, Koyama, Sachiko, Deary, Vincent, Roberts, S Craig, Yanık, Hüseyin, Albayrak, Samet, Nováková, Lenka Martinec, Croijmans, Ilja, Mazal, Patricia Portillo, Moein, Shima T, Margulis, Eitan, Mignot, Coralie, Mariño, Sajidxa, Georgiev, Dejan, Kaushik, Pavan K, Malnic, Bettina, Wang, Hong, Seyed-Allaei, Shima, Yoluk, Nur, Razzaghi-Asl, Sara, Justice, Jeb M, Restrepo, Diego, Reed, Danielle R, Hummel, Thomas, Munger, Steven D, Hayes, John E, Indústries Alimentàries, Qualitat i Tecnologia Alimentària, Tecnologia Alimentària, Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, Mersin University, The Hebrew University of Jerusalem (HUJ), AbScent, Pennsylvania State University (Penn State), Penn State System, University of California [Irvine] (UC Irvine), University of California (UC), Université Côte d'Azur (UCA), University of Edinburgh, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Central Scientific Instruments Organisation (CSIR), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Medizinische Universität Wien = Medical University of Vienna, Groupement scientifique de Biologie et de Medecine Spatiale (GSBMS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES), Tata Institute for Fundamental Research (TIFR), Arizona State University [Tempe] (ASU), Universidad de Extremadura - University of Extremadura (UEX), Università degli Studi di Padova = University of Padua (Unipd), Yale School of Medicine [New Haven, Connecticut] (YSM), San Diego State University (SDSU), Aarhus University [Aarhus], University of Hertfordshire [Hatfield] (UH), Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), Neurosciences Sensorielles Comportement Cognition, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Turku, Aristotle University of Thessaloniki, Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Monell Chemical Senses Center, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Montréal (UdeM), Wageningen University and Research Centre (WUR), Medical Science University, Sidra Medicine [Doha, Qatar], Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University of Southern Queensland (USQ), Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA), DreamAir Llc, Charles University [Prague] (CU), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Massachusetts System (UMASS), Oregon State University (OSU), Ear Institute, UCL, Lyon Neuroscience Research center, Karunya University, Biruni University, Assi Sette Llaghi Varese, Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, University of East Anglia [Norwich] (UEA), California Department of Food and Agriculture (CDFA), Unité mixte de recherche interactions plantes-microorganismes, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Maastricht University [Maastricht], Institute for Biology - Neurobiology, Freie Universität Berlin, Karl-Franzens-Universität Graz, Howard University College of Medicine, Towson University, University of California [San Diego] (UC San Diego), Proteomics, Center for Applied Medical Research (CIMA), Stockholm University, University of Gastronomic Sciences, Iran University of Medical Sciences, Goethe Universität Frankfurt, University of Tennessee, IBM T.J. Watson Research Center, Université libre de Bruxelles (ULB), Guangzhou Medical University, Buenos Aires University and GEOG (Grupo de Estudio de Olfato y Gusto), Sultan Qaboos University (SQU), Federal University of Technology of Akure (FUTA), A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences [Moscow] (RAS), Hospital of Xi'an Jiaotong University, University of Pennsylvania, University of Dayton, CSIRO Agriculture and Food (CSIRO), Indiana University [Bloomington], Indiana University System, University of Northumbria at Newcastle [United Kingdom], University of Stirling, Middle East Technical University [Ankara] (METU), Utrecht University [Utrecht], Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Institute for Research in Fundamental Sciences [Tehran] (IPM), Hebrew University of Jerusalem, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Terrazas del Club Hipico, University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Tata Institute of Fundamental Research [Bangalore], Universidade de São Paulo = University of São Paulo (USP), University of Florida [Gainesville] (UF), University of Colorado Anschutz [Aurora], Center for Smell and Taste, Department of Food Science, Pennsylvania State University., Julien, Sabine, Tıp Fakültesi, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Department of Food and Nutrition, Senses and Food, Research Center Jülich, University of California [Irvine] (UCI), University of California, Università degli studi di Bari Aldo Moro (UNIBA), Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), University of Extremadura, University of Padova, Yale University School of Medicine, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, University of Helsinki, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institute of Agrifood Research and Technology (IRTA), Universita degli Studi di Padova, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Karl-Franzens-Universität [Graz, Autriche], University of California San Diego Health, University of Brussels, University of Pennsylvania [Philadelphia], Tata Institute of Fundamental Research, University of São Paulo (USP), UCL - SSS/IONS - Institute of NeuroScience, FSE Campus Venlo, and RS: FSE UCV

Subjects
Male, Taste, Physiology, Smagstab, Audiology, AcademicSubjects/SCI01180, Settore BIO/09 - Fisiologia, Behavioral Neuroscience, chemistry.chemical_compound, Olfaction Disorders, Taste Disorders, 0302 clinical medicine, RATINGS, Hyposmia, Surveys and Questionnaires, CHEMOSENSITIVITY, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Viral, PALADAR, 030223 otorhinolaryngology, Sensory Science and Eating Behaviour, media_common, TASTE, US NATIONAL-HEALTH, [SDV.IDA] Life Sciences [q-bio]/Food engineering, Middle Aged, Biological Sciences, 16. Peace & justice, Sensory Systems, 3. Good health, Smell, GCCR Group Author, ddc:540, Smell loss, Female, Original Article, medicine.symptom, Corrigendum, Coronavirus Infections, olfaction, Adult, somatosensation, medicine.medical_specialty, 663/664, Coronavirus disease 2019 (COVID-19), OLFACTORY DISORDERS, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), media_common.quotation_subject, Pneumonia, Viral, head and neck surgery, Aged, Betacoronavirus, COVID-19, Humans, Pandemics, SARS-CoV-2, Self Report, Somatosensory Disorders, Young Adult, Anosmia, Sensory system, Olfaction, 03 medical and health sciences, Chemesthesis, Physiology (medical), Perception, medicine, Neurology & Neurosurgery, Behaviour Change and Well-being, business.industry, R-PACKAGE, 3112 Neurosciences, Pneumonia, Parosmia, COMPONENT, Smagssans, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Sensoriek en eetgedrag, chemistry, Lugtetab, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery, Lugtesans
Abstract

Correction: Chemical Senses, Volume 46, 2021, bjab050, https://doi.org/10.1093/chemse/bjab050 Published: 08 December 2021 Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change +/- 100) revealed a mean reduction of smell (-79.7 +/- 28.7, mean +/- standard deviation), taste (-69.0 +/- 32.6), and chemesthetic (-37.3 +/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis.The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

Published
2020

28. Corrigendum to: More than smell: COVID-19 is associated with severe impairment of smell, taste, and chemesthesis

Author

Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G., Niv, Masha Y., Kelly, Christine E., Bakke, Alyssa J., Cooper, Keiland W., Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y., Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B., Gerkin, Richard C., Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C., Bhutani, Surabhi, Fjaeldstad, Alexander W., Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R., Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A., Lim, Juyun, Whitcroft, Katherine L., Colquitt, Lauren R., Ferdenzi, Camille, Brindha, Evelyn V., Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M., Fiorucci, Sébastien, Philpott, Carl M., Smith, Barry C., Lundström, Johan N., Mucignat, Carla, Parker, Jane K., Van Den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S., Heinbockel, Thomas, Shields, Vonnie D.C., Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E.A., Morini, Gabriella, Olofsson, Jonas K., Jalessi, Maryam, Karni, Noam, D'Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M., Alwashahi, Mohammed K., Welge-Lüssen, Antje, Freiherr, Jessica, De Groot, Jasper H.B., Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W., Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H., Voznessenskaya, Vera V., Chen, Jingguo, Sell, Elizabeth A., Walsh-Messinger, Julie, Archer, Nicholas S., Koyama, Sachiko, Deary, Vincent, Roberts, S.C., Yanlk, Hüseyin, Albayrak, Samet, Nováková, Lenka Martinec, Croijmans, Ilja, Mazal, Patricia Portillo, Moein, Shima T., Margulis, Eitan, Mignot, Coralie, Mariño, Sajidxa, Georgiev, Dejan, Kaushik, Pavan K., Malnic, Bettina, Wang, Hong, Seyed-Allaei, Shima, Yoluk, Nur, Razzaghi-Asl, Sara, Justice, Jeb M., Restrepo, Diego, Reed, Danielle R., Hummel, Thomas, Munger, Steven D., Hayes, John E., UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, and UCL - (SLuc) Service d'oto-rhino-laryngologie

Subjects
Behavioral Neuroscience, Sensoriek en eetgedrag, Behaviour Change and Well-being, Physiology, Physiology (medical), ddc:540, Life Science, Sensory Systems, Sensory Science and Eating Behaviour, VLAG
Abstract

This is a correction notice for article bjaa041 (DOI: https:// doi.org/10.1093/chemse/bjaa041), published 20 June 2020. An incorrect version of the caption to Figure 5 was mistakenly included in the published paper. An updated version is given below. Neither the data nor the paper's conclusions were affected by this correction. The authors sincerely apologize for the error. (A) Correlations between the 3 principal components with respect to changes in 3 chemosensory modalities (i.e., taste, smell, and chemesthesis). Shades of gray indicate positive correlation, whereas shades of red indicate negative correlations. White denotes no correlation. (B) Clusters of participants identified by k-means clustering. The scatterplot shows each participant's loading on dimension 1 (degree of smell and taste loss, PC1 on x-Axis) and dimension 2 (degree of chemesthesis loss, PC2 on y-Axis). Based on the centroid of each cluster, participants in cluster 1 (blue, N = 1767; top left) are generally characterized by significant smell, taste and chemesthesis loss. Participants in cluster 2 (orange, N = 1724; bottom center) are generally characterized by ratings that reflect smell/taste loss with preserved chemesthesis. Loadings for participants in cluster 3 (green, N = 548; right side) are generally characterized by reduced smell and taste loss, and preserved chemesthesis.

Published
2021

29. A Novel Olfactory Self-Test Effectively Screens for COVID-19

Author

Snitz, Kobi, primary, Honigstein, Danielle, additional, Weissgross, Reut, additional, Ravia, Aharon, additional, Mishor, Eva, additional, Perl, Ofer, additional, Karagach, Shiri, additional, Medhanie, Abebe, additional, Harel, Nir, additional, Shushan, Sagit, additional, Roth, Yehudah, additional, Iravani, Behzad, additional, Arshamian, Artin, additional, Ernst, Gernot, additional, Okamoto, Masako, additional, Poo, Cindy, additional, Bonacchi, Niccolò, additional, Mainen, Zachary, additional, Monteleone, Erminio, additional, Dinnella, Caterina, additional, Spinelli, Sara, additional, Mariño-Sánchez, Franklin, additional, Ferdenzi, Camille, additional, Smeets, Monique, additional, Touhara, Kazushige, additional, Bensafi, Moustafa, additional, Hummel, Thomas, additional, Lundström, Johan N., additional, and Sobel, Noam, additional

Published
2021
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30. Erratum: Relationship between odor intensity estimates and COVID-19 prevalence prediction in a Swedish population (Chem. Senses (2020) DOI: 10.1093/chemse/bjaa034)

Author

Iravani, Behzad, Arshamian, Artin, Ravia, Aharon, Mishor, Eva, Snitz, Kobi, Shushan, Sagit, Roth, Yehudah, Perl, Ofer, Honigstein, Danielle, Weissgross, Reut, Karagach, Shiri, Ernst, Gernot, Okamoto, Masako, Mainen, Zachary, Monteleone, Erminio, Dinnella, Caterina, Spinelli, Sara, Mariño-Sánchez, Franklin, Ferdenzi, Camille, Smeets, Monique, Touhara, Kazushige, Bensafi, Moustafa, Hummel, Thomas, Sobel, Noam, Lundström, Johan N., Leerstoel Smeets, and Social-cognitive and interpersonal determinants of behaviour

Abstract

This is a correction notice for article bjz034 (DOI: https://doi. org/10.1093/chemse/bjaa034), published on 22 May 2020. Due to an error in the script used to create subsections of Figure 1, there was both a shift in the intensity data and an erroneous calculation of error bars in all panels. Figure 1 and the accompanying figure legend have been revised to show the correct levels and error bars. This script error only affected visualization of the data in Figure 1 and did not impact the reported data or conclusions.(Figure Presented).

Published
2020

31. More than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis

Author

Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Pizio, Antonella di, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R., Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guárdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A., Lim, Juyun, Whitcroft, K.L., Colquitt, Lauren R., Ferdenzi, Camille, Brindha, Evelyn V., Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M., Fiorucci, Sébastien, Philpott, Carl M., Smith, Barry C., Lundström, Johan N., Mucignat, Carla, Parker, Jane K., Brink, Mirjam van den, Schmuker, Michael, Fischmeister, Florian P.S., Heinbockel, Thomas, Schilds, Vonnie D.C., Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E.A., Morini, Gabriella, Olofsson, Jonas K., Jalessi, Maryam, Karni, Noam, D'Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M., Alwashahi, Mohanned K., Welge-Lüssen, Antje, Freiherr, Jessica, Groot, Jasper H.B. de, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W., Reed, Danielle R., Hummel, Thomas, Munger, Steven D., Hayes, John E., and Publica

Abstract

Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (−79.7 ± 28.7, mean ± standard deviation), taste (−69.0 ± 32.6), and chemesthetic (−37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

Published
2020

38. The genome sequence and structure of rice chromosome 1

Author

Sasaki, Takuji, Matsumoto, Takashi, Yamamoto, Kimiko, Sakata, Katsumi, Baba, Tomoya, Katayose, Yuichi, Wu, Jianzhong, Niimura, Yoshihito, Cheng, Zhukuan, Nagamura, Yoshiaki, Antonio, Baltazar A., Kanamori, Hiroyuki, Hosokawa, Satomi, Masukawa, Masatoshi, Arikawa, Koji, Chiden, Yoshino, Hayashi, Mika, Okamoto, Masako, Ando, Tsuyu, Aoki, Hiroyoshi, Arita, Kohei, Hamada, Masao, Harada, Chizuko, Hijishita, Saori, Honda, Mikiko, Ichikawa, Yoko, Idonuma, Atsuko, Iijima, Masumi, Ikeda, Michiko, Ikeno, Maiko, Ito, Sachie, Ito, Tomoko, Ito, Yuichi, Ito, Yukiyo, Iwabuchi, Aki, Kamiya, Kozue, Karasawa, Wataru, Katagiri, Satoshi, Kikuta, Ari, Kobayashi, Noriko, Kono, Izumi, Machita, Kayo, Maehara, Tomoko, Mizuno, Hiroshi, Mizubayashi, Tatsumi, Mukai, Yoshiyuki, Nagasaki, Hideki, Nakashima, Marina, Nakama, Yuko, Nakamichi, Yumi, Nakamura, Mari, Namiki, Nobukazu, Negishi, Manami, Ohta, Isamu, Ono, Nozomi, Saji, Shoko, Sakai, Kumiko, Shibata, Michie, Shimokawa, Takanori, Shomura, Ayahiko, Song, Jianyu, Takazaki, Yuka, Terasawa, Kimihiro, Tsuji, Kumiko, Waki, Kazunori, Yamagata, Harumi, Yamane, Hiroko, Yoshiki, Shoji, Yoshihara, Rie, Yukawa, Kazuko, Zhong, Huisun, Iwama, Hisakazu, Endo, Toshinori, Ito, Hidetaka, Hahn, Jang Ho, Kim, Ho-Il, Eun, Moo-Young, Yano, Masahiro, Jiang, Jiming, and Gojobori, Takashi

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Takuji Sasaki (corresponding author) [1]; Takashi Matsumoto [1]; Kimiko Yamamoto [1]; Katsumi Sakata [1]; Tomoya Baba [1]; Yuichi Katayose [1]; Jianzhong Wu [1]; Yoshihito Niimura [2]; Zhukuan Cheng [3]; [...]

Published
2002
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39. Corrigendum to: Relationship Between Odor Intensity Estimates and COVID-19 Prevalence Prediction in a Swedish Population

Author

Iravani, Behzad, primary, Arshamian, Artin, primary, Ravia, Aharon, primary, Mishor, Eva, primary, Snitz, Kobi, primary, Shushan, Sagit, primary, Roth, Yehudah, primary, Perl, Ofer, primary, Honigstein, Danielle, primary, Weissgross, Reut, primary, Karagach, Shiri, primary, Ernst, Gernot, primary, Okamoto, Masako, primary, Mainen, Zachary, primary, Monteleone, Erminio, primary, Dinnella, Caterina, primary, Spinelli, Sara, primary, Mariño-Sánchez, Franklin, primary, Ferdenzi, Camille, primary, Smeets, Monique, primary, Touhara, Kazushige, primary, Bensafi, Moustafa, primary, Hummel, Thomas, primary, Sobel, Noam, primary, and Lundström, Johan N, primary

Published
2020
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40. Relationship Between Odor Intensity Estimates and COVID-19 Prevalence Prediction in a Swedish Population

Author

Iravani, Behzad, primary, Arshamian, Artin, primary, Ravia, Aharon, primary, Mishor, Eva, primary, Snitz, Kobi, primary, Shushan, Sagit, primary, Roth, Yehudah, primary, Perl, Ofer, primary, Honigstein, Danielle, primary, Weissgross, Reut, primary, Karagach, Shiri, primary, Ernst, Gernot, primary, Okamoto, Masako, primary, Mainen, Zachary, primary, Monteleone, Erminio, primary, Dinnella, Caterina, primary, Spinelli, Sara, primary, Mariño-Sánchez, Franklin, primary, Ferdenzi, Camille, primary, Smeets, Monique, primary, Touhara, Kazushige, primary, Bensafi, Moustafa, primary, Hummel, Thomas, primary, Sobel, Noam, primary, and Lundström, Johan N, primary

Published
2020
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41. Relationship between odor intensity estimates and COVID-19 population prediction in a Swedish sample

Author

Iravani, Behzad, primary, Arshamian, Artin, additional, Ravia, Aharon, additional, Mishor, Eva, additional, Snitz, Kobi, additional, Shushan, Sagit, additional, Roth, Yehudah, additional, Perl, Ofer, additional, Honigstein, Danielle, additional, Weissgross, Reut, additional, Karagach, Shiri, additional, Ernst, Gernot, additional, Okamoto, Masako, additional, Mainen, Zachary, additional, Monteleone, Erminio, additional, Dinnella, Caterina, additional, Spinelli, Sara, additional, Mariño-Sánchez, Franklin, additional, Ferdenzi, Camille, additional, Smeets, Monique, additional, Touhara, Kazushige, additional, Bensafi, Moustafa, additional, Hummel, Thomas, additional, Sobel, Noam, additional, and Lundström, Johan N., additional

Published
2020
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42. A novel bacterial ATP-binding cassette transporter system that allows uptake of macromolecules

Author

Momma, Keiko, Okamoto, Masako, Mishima, Yumiko, Mori, Shigetarou, Hashimoto, Wataru, and Murata, Kousaku

Subjects
Bacteriology -- Research, Adenosine triphosphate -- Research, Macromolecules -- Research, Gram-negative bacteria -- Research, Biological sciences
Abstract

Research has been conducted on the gram-negative bacterium Sphingomonas sp. strain A1 that forms a mouth-like pit on its surface. Results suggest the existence of the pit-dependent ABC transporter system that allows macromolecule uptake.

Published
2000

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