Search

Your search keyword '"Okala, Sandra G."' showing total 7 results
Start Over Author "Okala, Sandra G."
7 results on '"Okala, Sandra G."'

3. Impact of nutritional supplementation during pregnancy on antibody responses to diphtheria-tetanus-pertussis vaccination in infants: A randomised trial in The Gambia

Author

Okala, Sandra G., Darboe, Momodou K., Sosseh, Fatou, Sonko, Bakary, Faye-Joof, Tisbeh, Prentice, Andrew M., and Moore, Sophie E.

Subjects
Clinical trials -- Analysis, Infants -- Health aspects, Diphtheria-tetanus-pertussis vaccines -- Usage, Pregnancy -- Health aspects, Dietary supplements -- Health aspects, Nutrition, Child development, Immune response, Folic acid, Immune system, Pregnant women, Vaccination, Diphtheria, Biological sciences
Abstract

Background Exposure to a nutritionally deficient environment during fetal life and early infancy may adversely alter the ontogeny of the immune system and affect an infant's ability to mount an optimal immune response to vaccination. We examined the effects of maternal nutritional supplementation during pregnancy on infants' antibody responses to the diphtheria-tetanus-pertussis (DTP) vaccine included in the Expanded Programme on Immunisation (EPI). Methods and findings The Early Nutrition and Immune Development (ENID) trial was a randomised, partially blinded trial conducted between April 2010 and February 2015 in the rural West Kiang region of The Gambia, a resource-poor region affected by chronic undernutrition. Pregnant women ( Conclusion According to our results from rural Gambia, maternal supplementation with MMN combined with PE during pregnancy enhanced antibody responses to the DTP vaccine in early infancy. Provision of nutritional supplements to pregnant women in food insecure settings may improve infant immune development and responses to EPI vaccines. Trial registration ISRCTN49285450., Author(s): Sandra G. Okala 1, Momodou K. Darboe 2, Fatou Sosseh 2, Bakary Sonko 2, Tisbeh Faye-Joof 2, Andrew M. Prentice 2, Sophie E. Moore 1,2,* Introduction The Expanded Programme [...]

Published
2019
Full Text
View/download PDF

4. Additional file 1 of Seasonal modulation of antibody response to diphtheria-tetanus-pertussis vaccination in infants: a cohort study in rural Gambia

Author

Okala, Sandra G., Darboe, Momodou K., Sosseh, Fatou, Sonko, Bakary, Faye-Joof, Tisbeh, Prentice, Andrew M., and Moore, Sophie E.

Subjects
complex mixtures
Abstract

Additional file 1: Figure S1. Design of the antenatal phase of the trial. Table S1. Nutritional composition of the allocated daily intake of pregnancy supplements. Table S2. Mean diphtheria, tetanus and pertussis antibody titres in infants at 12 and 24 weeks of age by season of mid-gestation and first DTP vaccination. Table S3. Percentage (n (%)) of infants with protective antibody levels against diphtheria, tetanus and pertussis at 12 and 24 weeks of age by mid-gestation and vaccination seasons. Figure S2. Comparisons of mean concentrations (95% confidence intervals) of diphtheria, tetanus and pertussis antibodies by season of vaccination and maternal nutritional supplementation groups.

Published
2021
Full Text
View/download PDF

6. Additional file 1 of Maternal plasma lipid levels across pregnancy and the risks of small-for-gestational age and low birth weight: a cohort study from rural Gambia

Author

Okala, Sandra G., Ebrima A. Sise, Fatou Sosseh, Prentice, Andrew M., Woollett, Laura A., and Moore, Sophie E.

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Additional file 1 Table A1. Nutritional composition of the allocated daily intake of pregnancy supplements. Table A2. Relative risk of LBW (95%CI) associated with maternal total, HDL and LDL cholesterol and triglycerides levels at enrolment, 20 and 30 weeks gestation. Table A3. Relative risk of SGA (95%CI) associated with maternal total, HDL and LDL cholesterol and triglycerides levels at enrolment, 20 and 30 weeks’ gestation. Table A4. Associations between maternal nutritional supplement groups and maternal total, HDL and LDL cholesterol and triglycerides levels at enrolment, 20 and 30 weeks gestation. Table A5. Beta coefficients (95% confidence intervals) of associations between maternal total, HDL, LDL cholesterol and triglycerides levels and BMI at enrolment, 20 and 30 weeks gestation. Table A6. Associations between maternal nutritional supplement groups and maternal BMI at enrolment, 20 and 30 weeks gestation. Table A7. Relative risk of LBW and SGA by maternal nutritional supplementation groups. Table A8. Beta coefficient of the associations between maternal nutritional supplement groups during pregnancy and birth weight.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results