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1,235 results on '"Okada, Takuya"'

5. Exploring Connections Between Eye Movements and the Big Five Personality Traits

Author

Tahara, Yuya, Inaba, Issei, Saito, Yukio, Hitomi, Toru, Okada, Takuya, Honda, Yuka, Katura, Takusige, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, van Leeuwen, Jan, Series Editor, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Kobsa, Alfred, Series Editor, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Nierstrasz, Oscar, Series Editor, Pandu Rangan, C., Editorial Board Member, Sudan, Madhu, Series Editor, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Deshpande, R.D., Series Editor, Vardi, Moshe Y, Series Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Mori, Hirohiko, editor, and Asahi, Yumi, editor

Published
2024
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8. Side branch embolization before endovascular abdominal aortic aneurysm repair to prevent type II endoleak: A prospective multicenter study

Author

Gentsu, Tomoyuki, Yamaguchi, Masato, Sasaki, Koji, Kawasaki, Ryota, Horinouchi, Hiroki, Fukuda, Tetsuya, Miyamoto, Naokazu, Mori, Takeki, Sakamoto, Noriaki, Uotani, Kensuke, Taniguchi, Takanori, Koda, Yojiro, Yamanaka, Katsuhiro, Takahashi, Hiroaki, Okada, Kenji, Hayashi, Taro, Watanabe, Toshitaka, Nomura, Yoshikatsu, Matsushiro, Keigo, Ueshima, Eisuke, Okada, Takuya, Sugimoto, Koji, and Murakami, Takamichi

Published
2024
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10. Pre-emptive Aortic Side Branch Embolization during Endovascular Aneurysm Repair Using the Excluder Stent-Graft System: A Prospective Multicenter study

Author

Sasaki, Koji, Yamaguchi, Masato, Gentsu, Tomoyuki, Kawasaki, Ryota, Miyamoto, Naokazu, Uotani, Kensuke, Sakamoto, Noriaki, Fukuda, Tetsuya, Horinouchi, Hiroki, Taniguchi, Takanori, Mori, Takeki, Koda, Yojiro, Yamanaka, Katsuhiro, Takahashi, Hiroaki, Okada, Kenji, Watanabe, Toshitaka, Hayashi, Taro, Nomura, Yoshikatsu, Matsushiro, Keigo, Ueshima, Eisuke, Okada, Takuya, Sugimoto, Koji, and Murakami, Takamichi

Published
2024
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17. Lessons from Two Design–Build–Test–Learn Cycles of Dodecanol Production in Escherichia coli Aided by Machine Learning

Author

Opgenorth, Paul, Costello, Zak, Okada, Takuya, Goyal, Garima, Chen, Yan, Gin, Jennifer, Benites, Veronica, de Raad, Markus, Northen, Trent R, Deng, Kai, Deutsch, Samuel, Baidoo, Edward EK, Petzold, Christopher J, Hillson, Nathan J, Martin, Hector Garcia, and Beller, Harry R

Subjects
Biochemistry and Cell Biology, Biological Sciences, Industrial Biotechnology, Bioengineering, Biotechnology, Algorithms, Dodecanol, Escherichia coli, Machine Learning, Metabolic Engineering, Metabolic Networks and Pathways, Synthetic Biology, DBTL, machine learning, dodecanol, proteomics, synthetic biology, Medicinal and Biomolecular Chemistry, Biomedical Engineering, Biochemistry and cell biology, Bioinformatics and computational biology
Abstract

The Design-Build-Test-Learn (DBTL) cycle, facilitated by exponentially improving capabilities in synthetic biology, is an increasingly adopted metabolic engineering framework that represents a more systematic and efficient approach to strain development than historical efforts in biofuels and biobased products. Here, we report on implementation of two DBTL cycles to optimize 1-dodecanol production from glucose using 60 engineered Escherichia coli MG1655 strains. The first DBTL cycle employed a simple strategy to learn efficiently from a relatively small number of strains (36), wherein only the choice of ribosome-binding sites and an acyl-ACP/acyl-CoA reductase were modulated in a single pathway operon including genes encoding a thioesterase (UcFatB1), an acyl-ACP/acyl-CoA reductase (Maqu_2507, Maqu_2220, or Acr1), and an acyl-CoA synthetase (FadD). Measured variables included concentrations of dodecanol and all proteins in the engineered pathway. We used the data produced in the first DBTL cycle to train several machine-learning algorithms and to suggest protein profiles for the second DBTL cycle that would increase production. These strategies resulted in a 21% increase in dodecanol titer in Cycle 2 (up to 0.83 g/L, which is more than 6-fold greater than previously reported batch values for minimal medium). Beyond specific lessons learned about optimizing dodecanol titer in E. coli, this study had findings of broader relevance across synthetic biology applications, such as the importance of sequencing checks on plasmids in production strains as well as in cloning strains, and the critical need for more accurate protein expression predictive tools.

Published
2019

24. Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner.

Author

Hayee, Abdul, Kobayashi, Eiji, Motozono, Chihiro, Hamana, Hiroshi, My, Ha Thi Viet, Okada, Takuya, Toyooka, Naoki, Yamaguchi, Satoshi, Ozawa, Tatsuhiko, and Kishi, Hiroyuki

Subjects
T cells, TUMOR-infiltrating immune cells, BREAST cancer, CANCER cells, SCHIFF bases, T cell receptors
Abstract

The MHC class I-related 1 (MR1) molecule is a non-polymorphic antigen-presenting molecule that presents several metabolites to MR1-restricted T cells, including mucosal-associated invariant T (MAIT) cells. MR1 ligands bind to MR1 molecules by forming a Schiff base with the K43 residue of MR1, which induces the folding of MR1 and its reach to the cell surface. An antagonistic MR1 ligand, Ac-6-FP, and the K43A mutation of MR1 are known to inhibit the responses of MR1-restricted T cells. In this study, we analyzed MR1-restricted TCRs obtained from tumor-infiltrating lymphocytes (TILs) from breast cancer patients. They responded to two breast cancer cell lines independently from microbial infection and did not respond to other cancer cell lines or normal breast cells. Interestingly, the reactivity of these TCRs was not inhibited by Ac-6-FP, while it was attenuated by the K43A mutation of MR1. Our findings suggest the existence of a novel class of MR1-restricted TCRs whose antigen is expressed in some breast cancer cells and binds to MR1 depending on the K43 residue of MR1 but without being influenced by Ac-6-FP. This work provides new insight into the physiological roles of MR1 and MR1-restricted T cells. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice

Author

Takahashi, Aki, Durand-de Cuttoli, Romain, Flanigan, Meghan E., Hasegawa, Emi, Tsunematsu, Tomomi, Aleyasin, Hossein, Cherasse, Yoan, Miya, Ken, Okada, Takuya, Keino-Masu, Kazuko, Mitsui, Koshiro, Li, Long, Patel, Vishwendra, Blitzer, Robert D., Lazarus, Michael, Tanaka, Kenji F., Yamanaka, Akihiro, Sakurai, Takeshi, Ogawa, Sonoko, and Russo, Scott J.

Published
2022
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34. Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma

Author

Mizuguchi, Mineyuki, primary, Nakagawa, Yusuke, additional, Yokoyama, Takeshi, additional, Okada, Takuya, additional, Fujii, Kanako, additional, Takahashi, Kanoko, additional, Luan, Nguyen Ngoc Thanh, additional, Nabeshima, Yuko, additional, Kanamitsu, Kayoko, additional, Nakagawa, Shinsaku, additional, Yamakawa, Shiori, additional, Ueda, Mitsuharu, additional, Ando, Yukio, additional, and Toyooka, Naoki, additional

Published
2024
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37. Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases)

Author

Hara, Hitomi, Sakai, Yoshitada, Kawamoto, Teruya, Fukase, Naomasa, Kawakami, Yohei, Takemori, Toshiyuki, Fujiwara, Shuichi, Kitayama, Kazumichi, Yahiro, Shunsuke, Miyamoto, Tomohiro, Kakutani, Kenichiro, Niikura, Takahiro, Miyawaki, Daisuke, Okada, Takuya, Sakashita, Akihiro, Imamura, Yoshinori, Sasaki, Ryohei, Kizawa, Yoshiyuki, Minami, Hironobu, Matsumoto, Tomoyuki, Matsushita, Takehiko, Kuroda, Ryosuke, and Akisue, Toshihiro

Published
2021
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38. Involvement of Cav3.2 T-type Ca2+channels and cystathionine-β-synthase in colitis-related visceral hypersensitivity in mice

Author

Tsubota, Maho, Iba, Yuriko, Hatakeyama, Tsukasa, Honda, Myu, Kasanami, Yoshihito, Sekiguchi, Fumiko, Kawase, Atsushi, Okada, Takuya, Toyooka, Naoki, and Kawabata, Atsufumi

Abstract

We tested the hypothesis that Cav3.2 T-type Ca2+channels, which can be rebooted by sulfides from Zn2+inhibition under physiological conditions, and sulfide-generating enzymes including cystathionine-β-synthase (CBS) would participate in the colitis-related visceral pain in mice treated with 2,4,6-trinitrobenzene sulfonic acid (TNBS). The visceral hypersensitivity following TNBS-induced colitis was abolished by an inhibitor or genetic deletion of Cav3.2 and by a CBS inhibitor, and accompanied by CBS upregulation in the colon. Our data thus suggest that the enhanced activity of Cav3.2 brought about by sulfides generated by upregulated CBS is involved in the colitis-related visceral hypersensitivity.

Published
2024
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