Search

Your search keyword '"Okada, Motoi"' showing total 133 results
Start Over Author "Okada, Motoi"
133 results on '"Okada, Motoi"'

1. Landiolol for Treatment of New-Onset Atrial Fibrillation in Critical Care: A Systematic Review.

Author

Levy, Bruno, Slama, Michel, Lakbar, Ines, Maizel, Julien, Kato, Hiromi, Leone, Marc, and Okada, Motoi

Subjects
ATRIAL fibrillation, CRITICAL care medicine, HEART beat, MEDICAL care, CARDIAC surgery
Abstract

Background: new-onset atrial fibrillation remains a common complication in critical care settings, often necessitating treatment when the correction of triggers is insufficient to restore hemodynamics. The treatment strategy includes electric cardioversion in cases of hemodynamic instability and either rhythm control or rate control in the absence of instability. Landiolol, an ultrashort beta-blocker, effectively controls heart rate with the potential to regulate rhythm. Objectives This review aims to compare the efficacy of landiolol in controlling heart rate and converting to sinus rhythm in the critical care setting. Methods: We conducted a comprehensive review of the published literature from 2000 to 2022 describing the use of landiolol to treat atrial fibrillation in critical care settings, excluding both cardiac surgery and medical cardiac care settings. The primary outcome assessed was sinus conversion following landiolol treatment. Results: Our analysis identified 17 publications detailing the use of landiolol for the treatment of 324 critical care patients. While the quality of the data was generally low, primarily comprising non-comparative studies, landiolol consistently demonstrated similar efficacy in controlling heart rate and facilitating conversion to sinus rhythm in both non-surgical (75.7%) and surgical (70.1%) settings. The incidence of hypotension associated with landiolol use was 13%. Conclusions: The use of landiolol in critical care patients with new-onset atrial fibrillation exhibited comparable efficacy and tolerance in both non-surgical and surgical settings. Despite these promising results, further validation through randomized controlled trials is necessary. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

2. Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy.

Author

Kuroshima, Tatsuki, Kawaguchi, Satoshi, and Okada, Motoi

Subjects
MITOCHONDRIA, CARDIOMYOPATHIES, HEART metabolism, ADENOSINE triphosphate, MYOCARDIAL reperfusion, MYOCARDIAL injury, ENERGY metabolism, BETA adrenoceptors
Abstract

Sepsis-induced cardiomyopathy (SICM) is one of the leading indicators for poor prognosis associated with sepsis. Despite its reversibility, prognosis varies widely among patients. Mitochondria play a key role in cellular energy production by generating adenosine triphosphate (ATP), which is vital for myocardial energy metabolism. Over recent years, mounting evidence suggests that severe sepsis not only triggers mitochondrial structural abnormalities such as apoptosis, incomplete autophagy, and mitophagy in cardiomyocytes but also compromises their function, leading to ATP depletion. This metabolic disruption is recognized as a significant contributor to SICM, yet effective treatment options remain elusive. Sepsis cannot be effectively treated with inotropic drugs in failing myocardium due to excessive inflammatory factors that blunt β-adrenergic receptors. This review will share the recent knowledge on myocardial cell death in sepsis and its molecular mechanisms, focusing on the role of mitochondria as an important metabolic regulator of SICM, and discuss the potential for developing therapies for sepsis-induced myocardial injury. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. Ischemic or Nonischemic Functional Mitral Regurgitation and Outcomes in Patients With Acute Decompensated Heart Failure With Preserved or Reduced Ejection Fraction

Author

Sato, Naoki, Asai, Kuniya, Munakata, Ryo, Aokage, Toshiyuki, Yoshida, Asuka, Minami, Yuichiro, Yumino, Dai, Mizuno, Masayuki, Kawada, Erisa, Yoshida, Kentaro, Ozaki, Yuri, Kogure, Tomohito, Haruki, Shintaro, Kajimoto, Katsuya, Nakao, Koichi, Sawamura, Tadashi, Nuki, Toshiaki, Ishiki, Ryoji, Yokota, Shigeki, Fujinaga, Hiroyuki, Yamamoto, Takashi, Harada, Kenji, Saito, Akihiro, Kageyama, Norihito, Okumura, Takanobu, Hata, Noritake, Murai, Koji, Nozaki, Ayaka, Kawanaka, Hidekazu, Tanabe, Jun, Sato, Yukihito, Ishii, Katsuhisa, Oiwa, Hitoshi, Matsumoto, Tomoaki, Yoshida, Daisuke, Kato, Nobuo, Suzuki, Hiroshi, Shimizu, Nobuyuki, Keida, Takehiko, Fujita, Masaki, Nakamura, Kentaro, Chinen, Toshiya, Meguro, Kentaro, Kikuchi, Tatsuro, Nishikido, Toshiyuki, Nakata, Marohito, Yamashita, Tatsuya, Nakata, Masaya, Hirono, Akitoshi, Mitsudo, Kazuaki, Kadota, Kazushige, Makita, Noriko, Watanabe, Nagisa, Kawabata, Masaaki, Fujii, Kenichi, Okuda, Shinichi, Kobayashi, Shigeki, Moriuchi, Ikuo, Mizuno, Kiyo-o, Osato, Kazuo, Murakami, Tatsuaki, Shimada, Yoshifumi, Misawa, Katsushi, Kokado, Hiromasa, Fujita, Takashi, Fukuoka, Yoshitomo, Takabatake, Syu, Takata, Yoshifumi, Miyagi, Manabu, Tanaka, Nobuhiro, Yamashina, Akira, Sudo, Shinji, Shimamura, Koichi, Nagashima, Michitaka, Kaneda, Tomoya, Ueda, Kosei, Kato, Hiromasa, Higashikata, Toshinori, Fujimori, Kanichi, Kobayashi, Hiroshi, Fujii, Shinya, Yagi, Masahiro, Takaki, Jyunko, Yamashita, Eiji, Toyama, Takuji, Hirata, Tetsuo, Kamisihima, Kazuho, Oka, Toshiaki, Komatsu, Ryushi, Itoh, Akira, Naruko, Takahiko, Abe, Yukio, Nakagawa, Eiichirou, Furukawa, Atsuko, Kinou, Naoto, Uematsu, Shoko, Tabuchi, Isao, Imai, Taku, Sakamoto, Takafumi, Todaka, Koji, Koide, Yuji, Maemura, Koji, Yoshioka, Koichiro, Yoshihisa, Akiomi, Sato, Takamasa, Takeishi, Yasuchika, Ebina, Toshiaki, Kimura, Kazuo, Konishi, Masaaki, Kato, Masahiko, Kinugasa, Yoshiharu, Ishida, Katsunori, Sugihara, Shinobu, Yanagihara, Kiyotaka, Takeuchi, Toshiharu, Okada, Motoi, Hasebe, Naoyuki, Sakai, Tetsuo, Asano, Taku, Minoura, Yoshino, Toshida, Tsutomu, Sato, Takatoshi, Yokota, Yuya, Kondo, Seita, Sakata, Yasushi, Komuro, Issei, Otsu, Kinya, Yamashita, Shizuya, Asano, Yoshihiro, Kashiwase, Kazunori, Ueda, Yasunori, Kondo, Taizo, Kawaguchi, Katsuhiro, Sawamura, Akinori, Saito, Taro, Higa, Toru, Noguchi, Hiroo, Yanagita, Yoko, Nakamura, Keita, Komaki, Tomo, Muramatsu, Toshihiro, Koizumi, Tomomi, Nakajima, Yoshie, Kikutani, Toshihiko, Ikeda, Yoshifimi, Tamaki, Toru, Funada, Shuhei, Ogawa, Harumi, Sakuragawa, Koichiro, Kohsaka, Shun, Ando, Shin-ichi, Kadokami, Toshiaki, Ishida, Eiko, Ide, Katsumi, Sotomi, Yohei, Higuchi, Yoshiharu, Uehara, Motoko, Goto, Toshihiko, Ohte, Nobuyuki, Miura, Masanobu, Shiba, Nobuyuki, Nochioka, Kotaro, Shimokawa, Hiroaki, Ishihara, Shiro, Koga, Tokushi, Fujishima, Shinichiro, Kaseda, Shigeru, Haga, Yoshie, Kida, Keisuke, Nakamura, Makiko, Sunagawa, Osahiko, Miyara, Takafumi, Taba, Youji, Touma, Takashi, Shinjo, Osamu, Nishimura, Yoshioki, Kario, Kazuomi, Shimizu, Hayato, Uchida, Takahiro, Amitani, Ken-ichi, Shimada, Katsunori, and Otsubo, Shigeru

Published
2017
Full Text
View/download PDF

18. Additional file 2: Figure S1. of Attenuation of teratoma formation by p27 overexpression in induced pluripotent stem cells

Author

Matsu-Ura, Toru, Sasaki, Hiroshi, Okada, Motoi, Mikoshiba, Katsuhiko, and Ashraf, Muhammad

Subjects
fungi
Abstract

Purification of p27 expressing miPSCs. Flow cytometric analysis of miPSCs (A), or p27-2A-mRFP stable transfected miPSCs (miPSCs-p27) before (B) and after (C) purification by cell sorter. Intensities of mRFP fluorescent were plotted against side scatters (SSC). The area surrounded by red line in B was sorted. (PDF 348 kb)

Published
2016
Full Text
View/download PDF

19. Ischemic or Nonischemic Functional Mitral Regurgitation and Outcomes in Patients With Acute Decompensated Heart Failure With Preserved or Reduced Ejection Fraction

Author

Kajimoto, Katsuya, primary, Minami, Yuichiro, additional, Otsubo, Shigeru, additional, Sato, Naoki, additional, Asai, Kuniya, additional, Munakata, Ryo, additional, Aokage, Toshiyuki, additional, Yoshida, Asuka, additional, Yumino, Dai, additional, Mizuno, Masayuki, additional, Kawada, Erisa, additional, Yoshida, Kentaro, additional, Ozaki, Yuri, additional, Kogure, Tomohito, additional, Haruki, Shintaro, additional, Kajimoto, Katsuya, additional, Nakao, Koichi, additional, Sawamura, Tadashi, additional, Nuki, Toshiaki, additional, Ishiki, Ryoji, additional, Yokota, Shigeki, additional, Fujinaga, Hiroyuki, additional, Yamamoto, Takashi, additional, Harada, Kenji, additional, Saito, Akihiro, additional, Kageyama, Norihito, additional, Okumura, Takanobu, additional, Hata, Noritake, additional, Murai, Koji, additional, Nozaki, Ayaka, additional, Kawanaka, Hidekazu, additional, Tanabe, Jun, additional, Sato, Yukihito, additional, Ishii, Katsuhisa, additional, Oiwa, Hitoshi, additional, Matsumoto, Tomoaki, additional, Yoshida, Daisuke, additional, Kato, Nobuo, additional, Suzuki, Hiroshi, additional, Shimizu, Nobuyuki, additional, Keida, Takehiko, additional, Fujita, Masaki, additional, Nakamura, Kentaro, additional, Chinen, Toshiya, additional, Meguro, Kentaro, additional, Kikuchi, Tatsuro, additional, Nishikido, Toshiyuki, additional, Nakata, Marohito, additional, Yamashita, Tatsuya, additional, Nakata, Masaya, additional, Hirono, Akitoshi, additional, Mitsudo, Kazuaki, additional, Kadota, Kazushige, additional, Makita, Noriko, additional, Watanabe, Nagisa, additional, Kawabata, Masaaki, additional, Fujii, Kenichi, additional, Okuda, Shinichi, additional, Kobayashi, Shigeki, additional, Moriuchi, Ikuo, additional, Mizuno, Kiyo-o, additional, Osato, Kazuo, additional, Murakami, Tatsuaki, additional, Shimada, Yoshifumi, additional, Misawa, Katsushi, additional, Kokado, Hiromasa, additional, Fujita, Takashi, additional, Fukuoka, Yoshitomo, additional, Takabatake, Syu, additional, Takata, Yoshifumi, additional, Miyagi, Manabu, additional, Tanaka, Nobuhiro, additional, Yamashina, Akira, additional, Sudo, Shinji, additional, Shimamura, Koichi, additional, Nagashima, Michitaka, additional, Kaneda, Tomoya, additional, Ueda, Kosei, additional, Kato, Hiromasa, additional, Higashikata, Toshinori, additional, Fujimori, Kanichi, additional, Kobayashi, Hiroshi, additional, Fujii, Shinya, additional, Yagi, Masahiro, additional, Takaki, Jyunko, additional, Yamashita, Eiji, additional, Toyama, Takuji, additional, Hirata, Tetsuo, additional, Kamisihima, Kazuho, additional, Oka, Toshiaki, additional, Komatsu, Ryushi, additional, Itoh, Akira, additional, Naruko, Takahiko, additional, Abe, Yukio, additional, Nakagawa, Eiichirou, additional, Furukawa, Atsuko, additional, Kinou, Naoto, additional, Uematsu, Shoko, additional, Tabuchi, Isao, additional, Imai, Taku, additional, Sakamoto, Takafumi, additional, Todaka, Koji, additional, Koide, Yuji, additional, Maemura, Koji, additional, Yoshioka, Koichiro, additional, Yoshihisa, Akiomi, additional, Sato, Takamasa, additional, Takeishi, Yasuchika, additional, Ebina, Toshiaki, additional, Kimura, Kazuo, additional, Konishi, Masaaki, additional, Kato, Masahiko, additional, Kinugasa, Yoshiharu, additional, Ishida, Katsunori, additional, Sugihara, Shinobu, additional, Yanagihara, Kiyotaka, additional, Takeuchi, Toshiharu, additional, Okada, Motoi, additional, Hasebe, Naoyuki, additional, Sakai, Tetsuo, additional, Asano, Taku, additional, Minoura, Yoshino, additional, Toshida, Tsutomu, additional, Sato, Takatoshi, additional, Yokota, Yuya, additional, Kondo, Seita, additional, Sakata, Yasushi, additional, Komuro, Issei, additional, Otsu, Kinya, additional, Yamashita, Shizuya, additional, Asano, Yoshihiro, additional, Kashiwase, Kazunori, additional, Ueda, Yasunori, additional, Kondo, Taizo, additional, Kawaguchi, Katsuhiro, additional, Sawamura, Akinori, additional, Saito, Taro, additional, Higa, Toru, additional, Noguchi, Hiroo, additional, Yanagita, Yoko, additional, Nakamura, Keita, additional, Komaki, Tomo, additional, Muramatsu, Toshihiro, additional, Koizumi, Tomomi, additional, Nakajima, Yoshie, additional, Kikutani, Toshihiko, additional, Ikeda, Yoshifimi, additional, Tamaki, Toru, additional, Funada, Shuhei, additional, Ogawa, Harumi, additional, Sakuragawa, Koichiro, additional, Kohsaka, Shun, additional, Ando, Shin-ichi, additional, Kadokami, Toshiaki, additional, Ishida, Eiko, additional, Ide, Katsumi, additional, Sotomi, Yohei, additional, Higuchi, Yoshiharu, additional, Uehara, Motoko, additional, Goto, Toshihiko, additional, Ohte, Nobuyuki, additional, Miura, Masanobu, additional, Shiba, Nobuyuki, additional, Nochioka, Kotaro, additional, Shimokawa, Hiroaki, additional, Ishihara, Shiro, additional, Koga, Tokushi, additional, Fujishima, Shinichiro, additional, Kaseda, Shigeru, additional, Haga, Yoshie, additional, Kida, Keisuke, additional, Nakamura, Makiko, additional, Sunagawa, Osahiko, additional, Miyara, Takafumi, additional, Taba, Youji, additional, Touma, Takashi, additional, Shinjo, Osamu, additional, Nishimura, Yoshioki, additional, Kario, Kazuomi, additional, Shimizu, Hayato, additional, Uchida, Takahiro, additional, Amitani, Ken-ichi, additional, and Shimada, Katsunori, additional

Published
2017
Full Text
View/download PDF

25. Laparoscopic Resection of Schwannoma of the Ascending Colon

Author

Tashiro, Yoshihiko, primary, Matsumoto, Fumio, additional, Iwama, Keiko, additional, Shimazu, Ai, additional, Matsumori, Sei, additional, Nohara, Shigeo, additional, Miura, Hiroyoshi, additional, Takei, Masahiko, additional, Namekata, Koji, additional, Takase, Masaru, additional, Okada, Motoi, additional, and Tsumura, Hidenori, additional

Published
2015
Full Text
View/download PDF

27. Report of a case: Retroperitoneal mucinous cystadenocarcinoma with rapid progression

Author

Kamiyama, Hirohiko, primary, Shimazu, Ai, additional, Makino, Yurika, additional, Ichikawa, Ryosuke, additional, Hobo, Takahiro, additional, Arima, Shuei, additional, Nohara, Shigeo, additional, Sugiyama, Yuji, additional, Okumura, Masafumi, additional, Takei, Masahiko, additional, Miura, Hiroyoshi, additional, Namekata, Koji, additional, Tsumura, Hidenori, additional, Okada, Motoi, additional, Takase, Masaru, additional, and Matsumoto, Fumio, additional

Published
2015
Full Text
View/download PDF

33. Prostacyclin Stimulated Integrin-Dependent Angiogenic Effects of Endothelial Progenitor Cells and Mediated Potent Circulation Recovery in Ischemic Hind Limb Model

Author

Aburakawa, Yoko, primary, Kawabe, Jun-ichi, additional, Okada, Motoi, additional, Yamauchi, Atsushi, additional, Asanome, Akira, additional, Kabara, Maki, additional, Matsuki, Motoki, additional, Takehara, Naofumi, additional, Nakagawa, Naoki, additional, Okumura, Shunsuke, additional, Minami, Yoshinori, additional, Mizukami, Yusuke, additional, Yuhki, Koh-ichi, additional, Ushikubi, Fumitaka, additional, and Hasebe, Naoyuki, additional

Published
2013
Full Text
View/download PDF

34. Blockade of senescence-associated micro RNA-195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells.

Author

Kondo, Hideyuki, Kim, Ha Won, Wang, Lei, Okada, Motoi, Paul, Christian, Millard, Ronald W., and Wang, Yigang

Subjects
CELLULAR aging, MICRORNA, SKELETAL muscle, MUSCLE cells, PLURIPOTENT stem cells, TELOMERASE reverse transcriptase
Abstract

The low reprogramming efficiency in cells from elderly patients is a challenge that must be overcome. Recently, it has been reported that senescence-associated micro RNA (miR)-195 targets Sirtuin 1 ( SIRT1) to advance cellular senescence. Thus, we hypothesized that a blockade of miR-195 expression could improve reprogramming efficiency in old skeletal myoblasts (SkMs). We found that miR-195 expression was significantly higher in old SkMs (24 months) isolated from C57 BL/6 mice as compared to young SkMs (2 months, 2.3-fold). Expression of SIRT1 and telomerase reverse transcriptase ( TERT) was downregulated in old SkMs, and transduction of old SkMs with lentiviral miR-195 inhibitor significantly restored their expression. Furthermore, quantitative in situ hybridization analysis demonstrated significant telomere elongation in old SkMs transduced with anti-miR-195 (1.7-fold increase). It is important to note that blocking miR-195 expression markedly increased the reprogramming efficiency of old SkMs as compared to scramble (2.2-fold increase). Transduction of anti-miR-195 did not alter karyotype or pluripotency marker expression. Induced pluripotent stem cells ( iPSCs) from old SkMs transduced with anti-miR-195 successfully formed embryoid bodies that spontaneously differentiated into three germ layers, indicating that deletion of miR-195 does not affect pluripotency in transformed SkMs. In conclusion, this study provided novel evidence that the blockade of age-induced miR-195 is a promising approach for efficient iPSC generation from aging donor subjects, which has the potential for autologous transplantation of iPSCs in elderly patients. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

35. Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase.

Author

Okada, Motoi, Kim, Ha Won, Matsu-ura, Kaoru, Wang, Yi-Gang, Xu, Meifeng, and Ashraf, Muhammad

Subjects
MICRORNA, CELLULAR aging, MESENCHYMAL stem cells
Abstract

A bstract Previously, we reported that a novel subpopulation of young mesenchymal stem cells (YMSCs) existed in old bone marrow, which possessed high antiaging properties as well as excellent efficacy for cardiac repair. MicroRNAs (miRNAs) have emerged as key regulators in post-transcriptional gene expression programs, and however, it is unknown whether miRNAs directly control stem cell senescence. Here we present the first evidence that miR-195 overexpressed in old MSCs (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase ( Tert), and abrogation of miR-195 can reverse stem cell aging. MiRNAs profiling analysis in YMSCs and OMSCs by microarray showed that miR-140, miR-146a/b, and miR-195 were significantly upregulated in OMSCs, which led us to hypothesize that these are age-induced miRNAs involved in stem cell senescence. Of these miRNAs, we found miR-195 directly targeted 3′-untranslated region of Tert gene by computational target prediction analysis and luciferase assay, and knockdown of miR-195 significantly increased Tert expression in OMSCs. Strikingly, miR-195 inhibition significantly induced telomere relengthening in OMSCs along with reduced expression of senescence-associated β-galactosidase. Moreover, silencing miR-195 in OMSCs by transfection of miR-195 inhibitor significantly restored antiaging factors expression including Tert and Sirt1 as well as phosphorylation of Akt and FOXO1. Notably, abrogation of miR-195 markedly restored proliferative abilities in OMSCs. Transplantation of OMSCs with knocked out miR-195 reduced infarction size and improved LV function. In conclusion, rejuvenation of aged stem cells by miR-195 inhibition would be a promising autologous therapeutic strategy for cardiac repair in the elderly patients. S tem C ells 2016;34:148-159 [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

38. Prostaglandin I 2 Promotes Recruitment of Endothelial Progenitor Cells and Limits Vascular Remodeling

Author

Kawabe, Jun-ichi, primary, Yuhki, Koh-ichi, additional, Okada, Motoi, additional, Kanno, Takayasu, additional, Yamauchi, Atsushi, additional, Tashiro, Naohiko, additional, Sasaki, Takaaki, additional, Okumura, Shunsuke, additional, Nakagawa, Naoki, additional, Aburakawa, Youko, additional, Takehara, Naofumi, additional, Fujino, Takayuki, additional, Hasebe, Naoyuki, additional, Narumiya, Shuh, additional, and Ushikubi, Fumitaka, additional

Published
2010
Full Text
View/download PDF

40. Possible Contribution of Ischemia of the Conus Branch to Induction or Augmentation of Brugada Type Electrocardiographic Changes in Patients With Coronary Artery Disease

Author

Yamaki, Masaru, primary, Sato, Nobuyuki, additional, Myojo, Takuya, additional, Nishiura, Takeshi, additional, Nishimura, Masato, additional, Nakamura, Hideki, additional, Okada, Motoi, additional, Fujita, Satoshi, additional, Go, Kazutomo, additional, Sakamoto, Naka, additional, Tanabe, Yasuko, additional, Takeuchi, Toshiharu, additional, Kawamura, Yuichiro, additional, and Hasebe, Naoyuki, additional

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results