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1,112 results on '"Okada, Kazunori"'

4. Determinants of exercise capacity in patients with heart failure without left ventricular hypertrophy

Author

Ishizaka, Suguru, Iwano, Hiroyuki, Tsujinaga, Shingo, Murayama, Michito, Tsuneta, Satonori, Aoyagi, Hiroyuki, Tamaki, Yoji, Motoi, Ko, Chiba, Yasuyuki, Tanemura, Asuka, Nakabachi, Masahiro, Yokoyama, Shinobu, Nishino, Hisao, Okada, Kazunori, Meyers, Brett A., Vlachos, Pavlos P., Sato, Takuma, Kamiya, Kiwamu, Watanabe, Masaya, Kaga, Sanae, Nagai, Toshiyuki, Oyama-Manabe, Noriko, and Anzai, Toshihisa

Published
2023
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5. Difference in left atrial myocardial dynamics during reservoir phase between hypertrophic cardiomyopathy and hypertensive heart determined using three-dimensional speckle tracking echocardiography

Author

Yanagi, Yusuke, Okada, Kazunori, Kaga, Sanae, Mikami, Taisei, Aiba, Miho, Masauzi, Nobuo, Murayama, Michito, Tanemura, Asuka, Yokoyama, Shinobu, Nishino, Hisao, Nakabachi, Masahiro, Tamaki, Yoji, Aoyagi, Hiroyuki, Motoi, Ko, Ishizaka, Suguru, Chiba, Yasuyuki, Tsujinaga, Shingo, Iwano, Hiroyuki, and Anzai, Toshihisa

Published
2022
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8. A Generic Approach to Lung Field Segmentation from Chest Radiographs using Deep Space and Shape Learning

Author

Mansoor, Awais, Cerrolaza, Juan J., Perez, Geovanny, Biggs, Elijah, Okada, Kazunori, Nino, Gustavo, and Linguraru, Marius George

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Computer-aided diagnosis (CAD) techniques for lung field segmentation from chest radiographs (CXR) have been proposed for adult cohorts, but rarely for pediatric subjects. Statistical shape models (SSMs), the workhorse of most state-of-the-art CXR-based lung field segmentation methods, do not efficiently accommodate shape variation of the lung field during the pediatric developmental stages. The main contributions of our work are: (1) a generic lung field segmentation framework from CXR accommodating large shape variation for adult and pediatric cohorts; (2) a deep representation learning detection mechanism, \emph{ensemble space learning}, for robust object localization; and (3) \emph{marginal shape deep learning} for the shape deformation parameter estimation. Unlike the iterative approach of conventional SSMs, the proposed shape learning mechanism transforms the parameter space into marginal subspaces that are solvable efficiently using the recursive representation learning mechanism. Furthermore, our method is the first to include the challenging retro-cardiac region in the CXR-based lung segmentation for accurate lung capacity estimation. The framework is evaluated on 668 CXRs of patients between 3 month to 89 year of age. We obtain a mean Dice similarity coefficient of $0.96\pm0.03$ (including the retro-cardiac region). For a given accuracy, the proposed approach is also found to be faster than conventional SSM-based iterative segmentation methods. The computational simplicity of the proposed generic framework could be similarly applied to the fast segmentation of other deformable objects.

Published
2018

9. Sensitivity and specificity of computer vision classification of eyelid photographs for programmatic trachoma assessment

Author

Kim, Matthew C, Okada, Kazunori, Ryner, Alexander M, Amza, Abdou, Tadesse, Zerihun, Cotter, Sun Y, Gaynor, Bruce D, Keenan, Jeremy D, Lietman, Thomas M, and Porco, Travis C

Subjects
Information and Computing Sciences, Biomedical and Clinical Sciences, Ophthalmology and Optometry, Clinical Research, Eye Disease and Disorders of Vision, Good Health and Well Being, Algorithms, Artificial Intelligence, Conjunctiva, Ethiopia, Eyelids, Humans, Image Processing, Computer-Assisted, Neural Networks, Computer, Niger, Photography, Prevalence, Trachoma, General Science & Technology
Abstract

Background/aimsTrachoma programs base treatment decisions on the community prevalence of the clinical signs of trachoma, assessed by direct examination of the conjunctiva. Automated assessment could be more standardized and more cost-effective. We tested the hypothesis that an automated algorithm could classify eyelid photographs better than chance.MethodsA total of 1,656 field-collected conjunctival images were obtained from clinical trial participants in Niger and Ethiopia. Images were scored for trachomatous inflammation-follicular (TF) and trachomatous inflammation-intense (TI) according to the simplified World Health Organization grading system by expert raters. We developed an automated procedure for image enhancement followed by application of a convolutional neural net classifier for TF and separately for TI. One hundred images were selected for testing TF and TI, and these images were not used for training.ResultsThe agreement score for TF and TI tasks for the automated algorithm relative to expert graders was κ = 0.44 (95% CI: 0.26 to 0.62, P < 0.001) and κ = 0.69 (95% CI: 0.55 to 0.84, P < 0.001), respectively.DiscussionFor assessing the clinical signs of trachoma, a convolutional neural net performed well above chance when tested against expert consensus. Further improvements in specificity may render this method suitable for field use.

Published
2019

13. Rice transcription factor DPF regulates stress-induced biosynthesis of diterpenoid phytoalexins.

Author

Ishikawa, Kazuki, Yamamura, Chihiro, Miyamoto, Koji, Kanda, Yasukazu, Inoue, Haruhiko, Okada, Kazunori, Kamakura, Takashi, and Mori, Masaki

Subjects
TRANSCRIPTION factors, JASMONIC acid, COPPER chlorides, RICE, ULTRAVIOLET radiation
Abstract

Diterpenoid Phytoalexin Factor (DPF) is a key transcription factor involved in diterpenoid phytoalexin (DP) biosynthesis under non-stressed conditions in rice (Oryza sativa L.). Using clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9, DPF knockout rice lines were generated. Treatments with abiotic stresses (copper chloride, ultraviolet light, and jasmonic acid) and biotic stress (blast fungus infection) to the knockout lines revealed that the DPF positively regulates stress-induced DP biosynthesis. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Mitochondrial‐targeting effector RsIA_CtaG/Cox11 in Rhizoctonia solaniAG‐1 IA has two functions: plant immunity suppression and cell death induction mediated by a rice cytochrome c oxidase subunit

Author

Zhang, Danhua, primary, Lin, Runmao, additional, Yamamoto, Naoki, additional, Wang, Zhaoyilin, additional, Lin, Hui, additional, Okada, Kazunori, additional, Liu, Yao, additional, Xiang, Xing, additional, Zheng, Tengda, additional, Zheng, Haoxi, additional, Yi, Xiaoqun, additional, Noutoshi, Yoshiteru, additional, and Zheng, Aiping, additional

Published
2023
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31. Simple and noninvasive method to estimate right ventricular operating stiffness based on echocardiographic pulmonary regurgitant velocity and tricuspid annular plane movement measurements during atrial contraction

Author

Murayama, Michito, Okada, Kazunori, Kaga, Sanae, Iwano, Hiroyuki, Tsujinaga, Shingo, Sarashina, Miwa, Nakabachi, Masahiro, Yokoyama, Shinobu, Nishino, Hisao, Nishida, Mutsumi, Shibuya, Hitoshi, Masauzi, Nobuo, Anzai, Toshihisa, and Mikami, Taisei

Published
2019
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35. Usefulness of the Continuous-Wave Doppler-Derived Pulmonary Arterial–Right Ventricular Pressure Gradient Just before Atrial Contraction for the Estimation of Pulmonary Arterial Diastolic and Wedge Pressures

Author

Murayama, Michito, Mikami, Taisei, Kaga, Sanae, Okada, Kazunori, Hioka, Takuma, Masauzi, Nobuo, Nakabachi, Masahiro, Nishino, Hisao, Yokoyama, Shinobu, Nishida, Mutsumi, Iwano, Hiroyuki, Sakakibara, Mamoru, Yamada, Satoshi, and Tsutsui, Hiroyuki

Published
2017
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36. Mitochondrial‐targeting effector RsIA_CtaG/Cox11 in Rhizoctonia solani AG‐1 IA has two functions: plant immunity suppression and cell death induction mediated by a rice cytochrome c oxidase subunit.

Author

Zhang, Danhua, Lin, Runmao, Yamamoto, Naoki, Wang, Zhaoyilin, Lin, Hui, Okada, Kazunori, Liu, Yao, Xiang, Xing, Zheng, Tengda, Zheng, Haoxi, Yi, Xiaoqun, Noutoshi, Yoshiteru, and Zheng, Aiping

Subjects
CYTOCHROME oxidase, CELL death, RHIZOCTONIA solani, DISEASE resistance of plants, RNA interference, RICE diseases & pests
Abstract

Rhizoctonia solani AG‐1 IA causes a necrotrophic rice disease and is a serious threat to rice production. To date, only a few effectors have been characterized in AG‐1 IA. We previously identified RsIA_CtaG/Cox11 and showed that infiltration of the recombinant protein into rice leaves caused disease‐like symptoms. In the present study, we further characterized the functionality of RsIA_CtaG/Cox11. RsIA_CtaG/Cox11 is an alternative transcript of cytochrome c oxidase copper chaperone Cox11 that starts from the second AUG codon, but contains a functional secretion signal peptide. RNA interference with RsIA_CtaG/Cox11 reduced the pathogenicity of AG‐1 IA towards rice and Nicotiana benthamiana without affecting its fitness or mycelial morphology. Transient expression of the RsIA_CtaG/Cox11‐GFP fusion protein demonstrated the localization of RsIA_CtaG/Cox11 to mitochondria. Agro‐infiltration of RsIA_CtaG/Cox11 into N. benthamiana leaves inhibited cell death by BAX and INF1. In contrast to rice, agro‐infiltration of RsIA_CtaG/Cox11 did not induce cell death in N. benthamiana. However, cell death was observed when it was coinfiltrated with Os_CoxVIIa, which encodes a subunit of cytochrome c oxidase. Os_CoxVIIa appeared to interact with RsIA_CtaG/Cox11. The cell death triggered by coexpression of RsIA_CtaG/Cox11 and Os_CoxVIIa is independent of the leucine‐rich repeat receptor kinases BAK1/SOBIR1 and enhanced the susceptibility of N. benthamiana to AG‐1 IA. Two of the three evolutionarily conserved cysteine residues at positions 25 and 126 of RsIA_CtaG/Cox11 were essential for its immunosuppressive activity, but not for cell death induction. This report suggests that RsIA_CtaG/Cox11 appears to have a dual role in immunosuppression and cell death induction during pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Do Tapping and Massaging during Tourniquet Application Promote Dilation of Forearm Cutaneous Veins? A Pilot Quasi-Experimental Study

Author

Yasuda, Kae, Okada, Kazunori, Sugimura, Naotaka, 1000050250519, Yano, Rika, Yasuda, Kae, Okada, Kazunori, Sugimura, Naotaka, 1000050250519, and Yano, Rika

Abstract

Successful insertion of a peripheral intravenous catheterization requires that veins be sufficiently dilated. This study aimed to clarify the venous dilation effect of including tapping or massaging to the application of a tourniquet at the cutaneous veins of healthy adults' forearms. This was a quasi-experimental study of 30 healthy adult volunteers. Each participant underwent all three venous dilation procedures, which included the tourniquet application (Control condition), the tourniquet application and tapping the participant's forearm (Tapping condition), as well as the tourniquet application combined with massaging the participant's forearm (Massage condition). To clarify the venous dilation effects, venous indices were measured, namely the venous diameter (mm), depth (mm), and palpation score. After applying all venous dilation procedures, the venous diameter and palpation score significantly increased. However, no significant difference was observed between the control condition and each intervention condition. The depth in the control and tapping conditions decreased significantly in contrast to the Massage condition. Moreover, a subgroup (nine participants with a venous diameter less than 3 mm after the control condition) had similar results. This study found that additional tapping or massaging after tourniquet application could be less effective in promoting dilation in the forearm veins of healthy adults. Future studies should examine the efficacy and effectiveness of venous dilation in a wide target population while considering intervention methods.

Published
2023

42. Additional file 7 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses

Author

Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, San Segundo, Blanca, Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, and San Segundo, Blanca

Abstract

Additional file 7: Table S6. Expression data (FPKM and Log2FC) of genes involved in Fe homeostasis in leaves of Control and High-Fe plants (M. oryzae-infected and mock-inoculated plants).

Published
2023

43. Additional file 8 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses

Author

Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, San Segundo, Blanca, Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, and San Segundo, Blanca

Abstract

Additional file 8: Table S7. Statistics for RNAseq analysis of leaves from Control and High-Fe plants, mock-inoculated and M. oryzae-inoculated (48 hpi).

Published
2023

44. Additional file 9 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses

Author

Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, San Segundo, Blanca, Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, and San Segundo, Blanca

Abstract

Additional file 9: Table S8. List of oligonucleotides used in this study.

Published
2023

45. Additional file 5 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses

Author

Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, San Segundo, Blanca, Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, and San Segundo, Blanca

Abstract

Additional file 5: Table S4. Expression data of defense-related genes in leaves of Control and High-Fe plants during M. oryzae infection (48 hpi).

Published
2023

46. Additional file 3 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses

Author

Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, San Segundo, Blanca, Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, and San Segundo, Blanca

Abstract

Additional file 3: Table S2. List of differentially expressed genes (DEGs) in leaves of High-Fe (S2a) and Control (S2b) plants at 48 hpi with M. oryzae spores, relative to the corresponding mock-inoculated plants.

Published
2023

47. Additional file 4 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses

Author

Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, San Segundo, Blanca, Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, and San Segundo, Blanca

Abstract

Additional file 4: Table S3. GO enrichment analysis of genes regulated by M.oryzae infection in High-Fe and Control plants relative to the corresponding mock-inoculated plants.

Published
2023

48. Additional file 6 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses

Author

Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, San Segundo, Blanca, Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, and San Segundo, Blanca

Abstract

Additional file 6: Table S5. Expression data (FPKM and Log2FC) of genes involved in the biosynthesis of diterpene phytoalexins and sakuranetin in leaves of Control and High-Fe plants (M. oryzae-infected and mock-inoculated plants).

Published
2023

49. Additional file 1 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses

Author

Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, San Segundo, Blanca, Consejo Superior de Investigaciones Científicas (España), Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, and San Segundo, Blanca

Abstract

Additional file 1: Fig. S1. Characterization of rice plants grown under different Fe conditions. Fig. S2. Venn diagrams representing transcriptional changes in response to M. oryzae infection in leaves of High-Fe and Control plants. Fig. S3. GO enrichment analysis of genes down-regulated by M. oryzae infection in Control and High-Fe plants (48 hpi). Fig. S4. Hierarchical clustering of differentially expressed genes by RNA-Seq analysis. Fig. S5. Phenylpropanoid biosynthesis pathway. Genes whose expression is regulated by M. oryzae infection are indicated. Fig. S6. Expression of diterpene phytoalexin biosynthetic genes in leaves of Control and High-Fe plants (−, mock-inoculated; +, M. oryzae- inoculated). Fig. S7. Accumulation of phytoalexins in leaves of Control and Low-Fe plants. Fig. S8. Expression of genes involved in Fe homeostasis in leaves of Control and High-Fe plants (−, mock-inoculated; +, M. oryzae- inoculated). Fig. S9. Malate dehydrogenase (MDH) assay in total protein extracts and apoplast fluid from Control and High-Fe plants (mock-inoculated and M. oryzae- inoculated). Fig. S10. Trypan blue staining for cell death in M. oryzae-infected leaves of Control and High-Fe rice plants. Fig. S11. Accumulation of Fe in sheaths of Low-Fe, Control-Fe, and High-Fe in rice plants that have been treated with the ferroptosis inhibitor Ferrostatin-1 (+ Fer-1), or not (− Fer-1).

Published
2023

50. Additional file 2 of Iron Induces Resistance Against the Rice Blast Fungus Magnaporthe oryzae Through Potentiation of Immune Responses

Author

Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, San Segundo, Blanca, Sánchez-Sanuy, Ferran, Mateluna-Cuadra, Roberto, Tomita, Keisuke, Okada, Kazunori, Sacchi, Gian Attilio, Campo, Sonia, and San Segundo, Blanca

Abstract

Additional file 2: Table S1. Differentially expressed genes (DEGs) in leaves of High-Fe plants relative to Control plants identified by RNASeq analysis (no infection conditions).

Published
2023

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