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As the global struggle to combat the quadruple burden of COVID-19, human immunodeficiency virus, tuberculosis and Lassa fever continues to increase, Sub-Saharan Africa has been the most affected region, especially Nigeria. There is a close interaction between these four diseases and a clear understanding of each of these diseases is very crucial. People living with chronic medical conditions such as HIV, TB and Lassa fever are more likely to experience poor outcomes from COVID-19 even though there are still some unknown facts as regards the burden of COVID-19 on patients with TB, Lassa fever and HIV in our low-middle–income nation. This study was conducted to review different researches on COVID-19 associated with HIV, TB and Lassa fever co-infections, to understand the interactions between them and its implications on clinical investigations and health management in high burden countries of COVID-19, especially Nigeria. The research was designed to accommodate research and reports from different geopolitical zones of Nigeria where the diseases has been reported and centering on Ondo State reports. This was done using search engines, with reference to valid studies from academic sources like ResearchGate, PubMed and Google Scholar. We also evaluated various related titles, abstracts and full reports for eligibility. Ondo state was the centre of study as it is one of the states with high prevalence of Lassa fever, TB, HIV and COVID-19 co-infections in Nigeria. Structured diagnostic algorithms and clinical management are suggested to improve COVID-19/HIV/TB/Lassa fever or COVID-19/Lassa fever co-infection outcomes. With low quality of health care facilities for laboratory diagnosis of COVID-19 and Lassa fever, reliance on clinical acumen and high index of suspicion may be the only process that health professionals may rely upon to make early diagnosis.

Background: Globally, hemoglobinopathies, which are genetic diseases of hemoglobin production, are a major cause of morbidity and mortality. African communities make up a sizable portion of the population that is susceptible to a variety of erythrocyte genetic and homological illnesses. Aim: The aim of this study is to investigate the prevalence and spectrum of hemoglobin variants among patients attending a tertiary hospital in South West Nigeria. Materials and Methods: The study research was conducted at the University of Medical Sciences Teaching Hospital, Ondo State Southwest Nigeria. Respondents were recruited from the hospital department clinics and tested at Department of Haematology, Faculty of basic medical science. Blood will be drawn via venipuncture into tubes that had been treated with the anticoagulant ethylene diamine tetracetic acid (EDTA) Results: The study show the frequency and gender distribution of different forms of haemoglobin (Hb) among the subjects; Hb AA 264; HbAS 60; HbAC 6; HbSC 8 and HbSS 12. Of the 350 subjects studied, 106 were males, while 244 were females. Among the male subjects, 85 were HbAA, 12 were HbAS; 2 were HbAC; 3 were HbSC and 4 were HbSS. Among the female subjects, 179 were HbAA, 48 were HbAS; 4 were HbAC; 5 were HbSC and 8 were HbSS. The study shows the frequency of the fetal hemoglobin among the Hb SS patients in the study based on age range. 50% of the participants with fetal hemoglobin were between 10-15 years, 25% were between 16-20 years, 8.3% were between 21-25 years, 8.4% were between 31-35 years and 8.3 % were between 36-40 years Conclusion: The study showed increased prevalence of various hemoglobin variants. Awareness should be created at religious centers, schools on the importance of genotype testing. As a preventative precaution. We advise the implementation of mutation identification and carrier screening.