Search

Your search keyword '"Ojanguren, Isabel"' showing total 45 results
Start Over Author "Ojanguren, Isabel"
45 results on '"Ojanguren, Isabel"'

2. High Prevalence of Liver Fibrosis Among European Adults With Unknown Liver Disease: A Population-Based Study

Author

Caballería, Llorenç, Pera, Guillem, Arteaga, Ingrid, Rodríguez, Lluís, Alumà, Alba, Morillas, Rosa M<ce:sup loc='post">a</ce:sup>, de la Ossa, Napoleón, Díaz, Alba, Expósito, Carmen, Miranda, Dolores, Sánchez, Carmen, Prats, Rosa M<ce:sup loc='post">a</ce:sup>, Urquizu, Marta, Salgado, Angels, Alemany, Magda, Martinez, Alba, Majeed, Irfan, Fabrellas, Núria, Graupera, Isabel, Planas, Ramón, Ojanguren, Isabel, Serra, Miquel, Torán, Pere, Caballería, Juan, and Ginès, Pere

Published
2018
Full Text
View/download PDF

15. Prognostic Value of the Burden of Cytomegalovirus Colonic Reactivation Evaluated by Immunohistochemical Staining in Patients with Active Ulcerative Colitis

Author

Clos-Parals, Ariadna, primary, Rodríguez-Martínez, Paula, additional, Cañete, Fiorella, additional, Mañosa, Míriam, additional, Ruiz-Cerulla, Alejandra, additional, José Paúles, Mª, additional, Llaó, Jordina, additional, Gordillo, Jordi, additional, Fumagalli, Caterina, additional, Garcia-Planella, Esther, additional, Ojanguren, Isabel, additional, Cabré, Eduard, additional, Guardiola, Jordi, additional, and Domènech, Eugeni, additional

Published
2018
Full Text
View/download PDF

16. CD5L is upregulated in hepatocellular carcinoma and promotes liver cancer cell proliferation and antiapoptotic responses by binding to HSPA5 (GRP78)

Author

Aran, Gemma, primary, Sanjurjo, Lucía, additional, Barcena, Cristina, additional, Simon‐Coma, Marina, additional, Téllez, Érica, additional, Vázquez‐Vitali, Maria, additional, Garrido, Marta, additional, Guerra, Laura, additional, Díaz, Esther, additional, Ojanguren, Isabel, additional, Elortza, Felix, additional, Planas, Ramon, additional, Sala, Margarita, additional, Armengol, Carolina, additional, and Sarrias, Maria‐Rosa, additional

Published
2018
Full Text
View/download PDF

17. Nodular Mucinosis of the Breast in a Male: Reassessment of Diagnostic Criteria and Proposal for Its Classification as a Soft Tissue Tumor in the Myofibroblastoma and Spindle Cell Lipoma Spectrum

Author

Fernandez Figueras, Maria Teresa, Kazakov, Dmitry V., López Martos, Raquel, Ojanguren, Isabel, Vilà Poyatos, Jordi, Ariza Fernández, A.., and Universitat Autònoma de Barcelona

Subjects
Pathology, medicine.medical_specialty, business.industry, Soft tissue, lcsh:RL1-803, medicine.disease, Mucinosis, Nipple, Case Studies, medicine.anatomical_structure, Cutaneous focal mucinosis, Myofibroblastoma, Spindle cell lipoma, lcsh:Dermatology, medicine, Immunohistochemistry, Breast, business, Carney complex, Areola
Abstract

Nodular mucinosis of the breast (NMB) is a rare entity with only a few cases described in the literature, most of them in young girls. All cases are located in the nipple and areolar area and microscopically consist of a multinodular myxoid mesenchymal proliferation. Bands of sclerotic collagen containing preexisting breast ducts and abundant vascularization are other features typical of NMB. No relation to Carney complex has been reported, and an indolent behavior is the rule in all patients. We present a case of NMB occurring in the nipple of a 46-year-old man and analyze the clinicopathological features of the other cases of NMB reported in the English literature, concluding that two of them most likely correspond to trauma-induced cutaneous focal mucinosis of the mammary areola. Finally, we review diagnostic criteria for NMB and elaborate an ontogenetic hypothesis based on both its morphological resemblance to myofibroblastoma and its immunohistochemical profile. © 2014 S. Karger AG, Basel

Published
2014
Full Text
View/download PDF

18. High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based study

Author

Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Generalitat de Catalunya, Institución Catalana de Investigación y Estudios Avanzados, Martínez, Alba [0000-0003-0667-1609], Torán. Pere [0000-0002-9865-7427], Ginès, Pere [0000-0003-4657-4504], Caballería, Llorenç, Pera, Guillem, Arteaga, Ingrid, Rodríguez, Lluis, Alumà, Alba, Morillas, Rosa María, Ossa, Napoleón de la, Díaz, Alba, Expósito, Carmen, Miranda, Dolores, Sánchez, Carmen, Prats, Rosa María, Urquizu, Marta, Salgado, Angels, Alemany, Magda, Martínez, Alba, Majeed, Irfan, Fabrellas, Núria, Graupera, Isabel, Planas, Ramón, Ojanguren, Isabel, Serra, Miquel, Torán. Pere, Caballería, Juan, Ginès, Pere, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Generalitat de Catalunya, Institución Catalana de Investigación y Estudios Avanzados, Martínez, Alba [0000-0003-0667-1609], Torán. Pere [0000-0002-9865-7427], Ginès, Pere [0000-0003-4657-4504], Caballería, Llorenç, Pera, Guillem, Arteaga, Ingrid, Rodríguez, Lluis, Alumà, Alba, Morillas, Rosa María, Ossa, Napoleón de la, Díaz, Alba, Expósito, Carmen, Miranda, Dolores, Sánchez, Carmen, Prats, Rosa María, Urquizu, Marta, Salgado, Angels, Alemany, Magda, Martínez, Alba, Majeed, Irfan, Fabrellas, Núria, Graupera, Isabel, Planas, Ramón, Ojanguren, Isabel, Serra, Miquel, Torán. Pere, Caballería, Juan, and Ginès, Pere

Abstract

[Background & Aims] Liver fibrosis is the main determinant of long-term outcome in chronic liver diseases. Little is known about the prevalence of liver fibrosis in the general population. The aim of the study was to investigate the prevalence of liver fibrosis in the general adult population with unknown liver disease., [Methods] This was a population-based, cross-sectional study performed in the Barcelona metropolitan area. Subjects aged 18 to 75 years old were identified randomly from citizens included in the primary health care registry. Of 4866 subjects invited, 3076 participated (63.2%). Liver fibrosis was estimated by measuring liver stiffness (LS) with transient elastography (TE). Liver histology was assessed in 92 subjects with increased LS., [Results] Prevalence estimates of increased LS (≥6.8, ≥8.0, and ≥9.0 kPa) were 9.0%, 5.8%, and 3.6%, respectively. The etiology of liver disease was mainly nonalcoholic fatty liver disease (NAFLD), followed by alcohol risk consumption (consumption of ≥21 standard drinking units/wk in men and ≥14 standard drinking units/wk in women). Factors independently associated with increased LS were male sex, abdominal obesity, type 2 diabetes, serum glucose, high-density lipoprotein, and triglyceride levels. Subjects without risk factors for NAFLD or without alcohol risk consumption had a very low prevalence of increased LS. The best cut-off value of LS for significant liver fibrosis (F2–F4) was 9.2 kPa, with high sensitivity and specificity. TE was more accurate than alanine aminotransferase, NAFLD fibrosis score, or Fibrosis 4. An algorithm for screening for liver fibrosis using TE in the community setting is proposed., [Conclusions] These findings show a high prevalence of silent liver disease with advanced fibrosis mainly related to NAFLD in adult European subjects without known liver disease. An LS value less than 9.2 kPa predicts the absence of significant liver fibrosis with high accuracy and could be used for screening purposes.

Published
2018

19. Prognostic Value of the Burden of Cytomegalovirus Colonic Reactivation Evaluated by Immunohistochemical Staining in Patients with Active Ulcerative Colitis.

Author

Clos-Parals, Ariadna, Rodríguez-Martínez, Paula, Cañete, Fiorella, Mañosa, Míriam, Ruiz-Cerulla, Alejandra, Paúles, Mª José, Llaó, Jordina, Gordillo, Jordi, Fumagalli, Caterina, Garcia-Planella, Esther, Ojanguren, Isabel, Cabré, Eduard, Guardiola, Jordi, and Domènech, Eugeni

Abstract

Background Colonic cytomegalovirus [CMV] reactivation has been involved in steroid refractoriness in patients with active ulcerative colitis [UC]. The benefits of antiviral therapy in this clinical setting are still under debate, but the burden of viral reactivation has been associated with a poorer outcome in some studies. Our aim was to assess whether the burden of CMV reactivation measured by the number of viral inclusions by immunohistochemistry [IHC-CMV] is associated with a risk of colectomy. Methods Biopsy sets of UC patients with positive IHC-CMV were identified from the Pathology departments of three university hospitals. All biopsies were reviewed by expert pathologists, and the maximum number of IHC-CMV–positive cells in each biopsy set was re-assessed. Epidemiological and clinical features and clinical outcomes were recorded. Results Forty-six positive IHC-CMV cases with UC were included. At the time of CMV reactivation, 70% were receiving corticosteroids, 33% azathioprine, and 24% anti–tumour necrosis factor [TNF] agents. Thirty-two patients [70%] were treated with antiviral therapy. The median number of IHC-CMV–positive cells was 2 cells/biopsy [IQR 1–4]. Fourteen patients [30%] underwent colectomy, and 4 of them [29%] showed persistence of CMV in the surgical specimen. In the multivariate analysis, colectomy was only associated with >2 positive cells/biopsy [ p = 0.048] and younger age [ p = 0.023]. Conclusions The burden of CMV colonic reactivation in patients with active UC, as measured by IHC, seems to be related to the risk of colectomy, and more data is needed to understand whether antiviral therapy guided by CMV burden will alter the clinical outcome. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

21. Interleukin-10 Enhances the Intestinal Epithelial Barrier in the Presence of Corticosteroids through p38 MAPK Activity in Caco-2 Monolayers: A Possible Mechanism for Steroid Responsiveness in Ulcerative Colitis

Author

Lorén, Violeta, primary, Cabré, Eduard, additional, Ojanguren, Isabel, additional, Domènech, Eugeni, additional, Pedrosa, Elisabet, additional, García-Jaraquemada, Arce, additional, Mañosa, Miriam, additional, and Manyé, Josep, additional

Published
2015
Full Text
View/download PDF

23. Second primary malignances (SPMs) in patients with gastrointestinal stromal tumors (GIST): The potential influence of imatinib treatment.

Author

Estival, Anna, primary, Espasa, Laia, additional, Etxaniz, Olatz, additional, Blanco, Ignacio, additional, Cuadra-Urteaga, Jose Luis, additional, Gil, Maria de los Llanos, additional, Balana, Carmen, additional, Ojanguren, Isabel, additional, Indacochea, Alberto, additional, Ahlal, Sara, additional, Vila, Laia, additional, Carcereny, Enric, additional, and Mijangos, Erika, additional

Published
2014
Full Text
View/download PDF

24. Prognostic value of miR-196, IDO, and AXL in patients (p) with localized gastrointestinal stromal tumors (GIST).

Author

Cuadra-Urteaga, Jose Luis, primary, Balana, Carmen, additional, Etxaniz, Olatz, additional, Chaib, Imane, additional, Ramirez, Jose Luis, additional, Mejia, Edwin, additional, Ojanguren, Isabel, additional, Estival, Anna, additional, Munoz, Ana, additional, Sanz, Carolina, additional, Indacochea, Alberto, additional, Ahlal, Sara, additional, Vila, Laia, additional, Gil, Maria de los Llanos, additional, Teruel, Iris, additional, Hardy, Max, additional, and Rosell, Rafael, additional

Published
2014
Full Text
View/download PDF

25. Biomarkers for Diagnosis and Monitoring of Celiac Disease

Author

Vives-Pi, Marta, primary, Takasawa, Shin, additional, Pujol-Autonell, Irma, additional, Planas, Raquel, additional, Cabre, Eduard, additional, Ojanguren, Isabel, additional, Montraveta, Montserrat, additional, Santos, Agustin L., additional, and Ruiz-Ortiz, Estíbaliz, additional

Published
2013
Full Text
View/download PDF

26. Effect of Liver Fibrosis on Long-Term Mortality in HIV/Hepatitis C Virus-Coinfected Individuals Who Are Evaluated to Receive Interferon Therapies in the Highly Active Antiretroviral Therapy Era

Author

Sanmartin, Ramon, primary, de Felipe, Elena, additional, Tor, Jordi, additional, Sanvicens, Arantza, additional, Barluenga, Eva, additional, Martinez, Elisenda, additional, Muga, Robert, additional, Jou, Antoni, additional, Ojanguren, Isabel, additional, López, Juan José, additional, Clotet, Bonaventura, additional, and Tural, Cristina, additional

Published
2012
Full Text
View/download PDF

33. Advanced Liver Fibrosis in HIV/HCV-Coinfected Patients on Antiretroviral Therapy

Author

Fuster, Daniel, primary, Planas, Ramon, additional, Muga, Robert, additional, Ballesteros, Angel L., additional, Santos, Justiniano, additional, Tor, Jordi, additional, Sirera, Guillem, additional, Guardiola, Helena, additional, Salas, Anna, additional, Cabré, Eduard, additional, Ojanguren, Isabel, additional, Barluenga, Eva, additional, Rey-Joly, Celestino, additional, Clotet, Bonaventura, additional, and Tural, Cristina, additional

Published
2004
Full Text
View/download PDF

35. Low doses of IGF-1 decrease histological damage, portal pressure (PP) and bacterial translocation (BT) in rats with cirrhosis induction

Author

Zuniga, Vicente Lorenzo, primary, Bartoli, Ramon, additional, Planas, Ramon, additional, Ortigosa, Carlos Rodriguez, additional, Cortazar, Inmaculada Castilla, additional, Vinado, Belen, additional, Ojanguren, Isabel, additional, Quiroga, Jorge, additional, Gassull, Miguel Angel, additional, and Prieto, Jesus Maria, additional

Published
2002
Full Text
View/download PDF

40. Cystic adrenal neuroblastoma: Prenatal diagnosis by ultrasonography

Author

Martínez-Mora, Joan, primary, Castellví, Antoni, additional, Coroleu, Wifredo, additional, Isnard, Rosa, additional, Javier, Germán, additional, López, Pílar, additional, Montserrat, Enric, additional, Natal, Antoni, additional, Ojanguren, Isabel, additional, and Orazabal, Angel, additional

Published
1995
Full Text
View/download PDF

42. Partial Replacement of Dietary (n-6) Fatty Acids with Medium-Chain Triglycerides Decreases the Incidence of Spontaneous Colitis in lnterleukin-10-Deficient Mice.

Author

Mañé, Josep, Pedrosa, Elisabet, Lorén, Violeta, Ojanguren, Isabel, Fluvià, Lourdes, Cabré, Eduard, Rogler, Gerhard, and GassulI, Miquel A.

Subjects
CROHN'S disease, DIET, NUTRITION, FATTY acids, TRIGLYCERIDES, COLITIS, INTERLEUKIN-10, MICE
Abstract

Enteral nutrition has a primary therapeutic effect in active Crohn's disease. It is unknown which nutrient(s) account for this action, but a role for both the amount and type of dietary fat has been postulated. Some clinical and experimental data suggest that medium-chain triglycerides (MCT) may reduce intestinal inflammation. We aimed to assess the effect of replacing part of the dietary fat with MCT on the incidence and severity of colitis in interleukin (IL)-10(-/-) mice under specific pathogen-free conditions. Twenty-four IL-10(-/-) 4-wk-old mice were randomized to receive a control diet based on sunflower oil [(n-6) fatty acids (FA)] and an experimental isocaloric, isonitrogenous diet with 50% sunflower and 50% coconut oil (MCT diet). When the mice were 12 wk old, they were killed and the colon was examined for the presence of colitis, lymphocyte subpopulations and apoptosis, ex vivo cytokine production in supernatant of colon explants, toll-like receptor (ILR)-2 and TLR-9 mRNA, and FA profile in colonic tissue homogenates. Colitis incidence was lower in the IL-10(-/-) mice fed the MCT diet (1/12) than in the mice fed the control diet 18/12; P= 0.03). The histological damage score was also lower in the former (P < 0.0005). Feeding the MCT diet resulted in fewer total and apoptotic intraepithelial CD3+ and lamina propria CD3+CD4+ lymphocytes, as well as downregulated production of IL-6 and interferon-γ, and reduced ILR-9 mRNA. We conclude that partial replacement of dietary (n-6) FA with MCT decreases the incidence of colitis in a model of spontaneous intestinal inflammation and provide experimental arguments for a possible primary therapeutic effect of MCT in human Crohn's disease. [ABSTRACT FROM AUTHOR]

Published
2009
Full Text
View/download PDF

43. Definition of a 3-Protein Signature to Stratify Hepatoblastoma Patients According to Their Prognosis

Author

Garrido, Marta, Guerra, Laura, Simon, Marina, Azkargorta, Mikel, Nonell, Lara, Lopez-Santamaria, Manuel, Mateos, Maria E., Belendez, Cristina, Plaza, Diego, Hernandez, Francisco, Mendiola, Marta, Ojanguren, Isabel, Childs, Margaret, Piotr Czauderna, Maibach, Rudolf, Morland, Bruce, Buendia, Marie A., Elortza, Felix, Planas, Ramon, Sarrias, Maria R., Sala, Margarita, and Armengol, Carolina

45. Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus?

Author

Julián MT, Alonso N, Ojanguren I, Pizarro E, Ballestar E, and Puig-Domingo M

Abstract

Hepatic glycogenosis (HG) is characterized by excessive glycogen accumulation in hepatocytes and represents a hepatic complication of diabetes that particularly occurs in patients with longstanding poorly controlled type 1 diabetes (T1D). HG has been reported to be a very rare disease, although it is believed to be extremely underdiagnosed because it is not possible to distinguish it from non-alcoholic fatty liver disease (NAFLD) unless a liver biopsy is performed. In contrast to HG, NAFLD is characterized by liver fat accumulation and is the more likely diagnosis for patients with type 2 diabetes and metabolic syndrome. The pathogenesis of HG involves the concomitant presence of insulin and excess glucose, which increases glycogen storage in the liver. HG is characterized by a transient elevation in liver transaminases and hepatomegaly. Differentiating between these two conditions is of the utmost importance because HG is a benign disease that is potentially reversible by improving glycemic control, whereas NAFLD can progress to cirrhosis. Therefore, HG should be suspected when liver dysfunction occurs in patients with poorly controlled T1D. The aim of this article is to review the epidemiology, clinical characteristics, pathogenesis and histology of HG.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results