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2. DNA methylation and stroke prognosis: an epigenome-wide association study

Author

Jiménez-Balado, Joan, Fernández-Pérez, Isabel, Gallego-Fábrega, Cristina, Lazcano, Uxue, Soriano-Tárraga, Carolina, Vallverdú-Prats, Marta, Mola-Caminal, Marina, Rey-Álvarez, Lucía, Macias-Gómez, Adrià, Suárez-Pérez, Antoni, Giralt-Steinhauer, Eva, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Ois, Ángel, Esteller, Manel, Roquer, Jaume, Fernández-Cadenas, Israel, and Jiménez-Conde, Jordi

Published
2024
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6. Blood Biomarkers of Alzheimer's Disease and Cognition: A Literature Review.

Author

García-Escobar, Greta, primary, Manero-Borràs, Rosa-María, additional, Fernández-Lebrero, Aida, additional, Ois, Ángel, additional, Navalpotro-Gómez, Irene, additional, Puente-Periz, Victor, additional, Contador, Jose, additional, Estragués-Gazques, Isabel, additional, Puig-Pijoan, Albert, additional, and Jimenez-Balado, Joan, additional

Published
2023
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7. Factors associated with poor anticoagulation control with vitamin K antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study

Author

Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, Rivera, José M., Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., and Suárez Fernández, C.

Published
2018
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8. Factores asociados al mal control de la anticoagulación con antivitamina K en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN

Author

Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, Rivera., José M., Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., and Suárez Fernández, C.

Published
2018
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9. Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age

Author

Jiménez-Balado, Joan, primary, Giralt-Steinhauer, Eva, additional, Fernández-Pérez, Isabel, additional, Rey, Lucía, additional, Cuadrado-Godia, Elisa, additional, Ois, Ángel, additional, Rodríguez-Campello, Ana, additional, Soriano-Tárraga, Carolina, additional, Lazcano, Uxue, additional, Macias-Gómez, Adrià, additional, Suárez-Pérez, Antoni, additional, Revert, Anna, additional, Estragués, Isabel, additional, Beltrán-Mármol, Brigitte, additional, Medrano-Martorell, Santiago, additional, Capellades, Jaume, additional, Roquer, Jaume, additional, and Jiménez-Conde, Jordi, additional

Published
2022
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10. Plasma levels of miRNA-1-3p are associated with subclinical atrial fibrillation in patients with cryptogenic stroke

Author

Benito, Begoña, primary, García-Elías, Anna, additional, Ois, Ángel, additional, Tajes, Marta, additional, Vallès, Ermengol, additional, Ble, Mireia, additional, Yáñez Bisbe, Laia, additional, Giralt-Steinhauer, Eva, additional, Rodríguez-Campello, Ana, additional, Cladellas Capdevila, Mercè, additional, Martí-Almor, Julio, additional, Roquer, Jaume, additional, and Cuadrado-Godia, Elisa, additional

Published
2022
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12. Ischemia preconditioning induces an adaptive response that defines a circulating metabolomic signature in ischemic stroke patients

Author

Sol, Joaquim, primary, Colàs-Campàs, Laura, additional, Mauri-Capdevila, Gerard, additional, Molina-Seguin, Jessica, additional, Galo-Licona, José Daniel, additional, Torres-Querol, Coral, additional, Aymerich, Núria, additional, Ois, Ángel, additional, Roquer, Jaume, additional, Tur, Silvia, additional, García-Carreira, María del Carmen, additional, Martí-Fàbregas, Joan, additional, Cruz-Culebras, Antonio, additional, Segura, Tomás, additional, Pamplona, Reinald, additional, Portero-Otín, Manel, additional, Arqué, Gloria, additional, Jové, Mariona, additional, and Purroy, Francisco, additional

Published
2022
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13. Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage

Author

Giralt-Steinhauer, Eva, primary, Jiménez-Balado, Joan, additional, Fernández-Pérez, Isabel, additional, Rey Álvarez, Lucía, additional, Rodríguez-Campello, Ana, additional, Ois, Ángel, additional, Cuadrado-Godia, Elisa, additional, Jiménez-Conde, Jordi, additional, and Roquer, Jaume, additional

Published
2022
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14. Increased COVID-19 Mortality in People With Previous Cerebrovascular Disease: A Population-Based Cohort Study

Author

Lazcano, Uxue, primary, Cuadrado-Godia, Elisa, additional, Grau, María, additional, Subirana, Isaac, additional, Martínez-Carbonell, Elisenda, additional, Boher-Massaguer, Marc, additional, Rodríguez-Campello, Ana, additional, Giralt-Steinhauer, Eva, additional, Fernández-Pérez, Isabel, additional, Jiménez-Conde, Jordi, additional, Roquer, Jaume, additional, and Ois, Ángel, additional

Published
2022
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15. Migraine Aura mimicking Stroke in Code Stroke. Analysis of diagnostic prediction models.

Author

Macias-Gómez, Adrià, primary, Suárez-Pérez, Antoni, additional, Rodríguez-Campello, Ana, additional, Giralt-Steinhauer, Eva, additional, Moreira, Antía, additional, Guisado-Alonso, Daniel, additional, Capellades, Jaume, additional, Fernández-Pérez, Isabel, additional, Jiménez-Conde, Jordi, additional, Rey, Lucía, additional, Jiménez-Baladó, Joan, additional, Roquer, Jaume, additional, Ois, Ángel, additional, and Cuadrado-Godia, Elisa, additional

Published
2022
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16. Epigenome-wide association study identifies TXNIP gene associated with type 2 diabetes mellitus and sustained hyperglycemia

Author

Soriano-Tárraga, Carolina, Jiménez-Conde, Jordi, Giralt-Steinhauer, Eva, Mola-Caminal, Marina, Vivanco-Hidalgo, Rosa M., Ois, Angel, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Sayols-Baixeras, Sergi, Elosua, Roberto, Roquer, Jaume, Jiménez-Conde, Jordi, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Mola, Marina, Ois, Ángel, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Roquer, Jaume, Krupinski, Jurek, Fernández-Cadenas, Israel, Rabionet, Kelly, Obach, Victor, Vivas, Tófol, Maria, Rosa, Navarro, Díaz, and Lilly, Elaine M.

Published
2016
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17. Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age.

Author

Jiménez-Balado, Joan, Giralt-Steinhauer, Eva, Fernández-Pérez, Isabel, Rey, Lucía, Cuadrado-Godia, Elisa, Ois, Ángel, Rodríguez-Campello, Ana, Soriano-Tárraga, Carolina, Lazcano, Uxue, Macias-Gómez, Adrià, Suárez-Pérez, Antoni, Revert, Anna, Estragués, Isabel, Beltrán-Mármol, Brigitte, Medrano-Martorell, Santiago, Capellades, Jaume, Roquer, Jaume, and Jiménez-Conde, Jordi

Subjects
AGE, WHITE matter (Nerve tissue), MAGNETIC resonance imaging, HUMAN DNA, CEREBRAL small vessel diseases
Abstract

Simple Summary: Biological age (B-age), or the degree of aging of an individual, can differ from chronological age. B-age is affected by epigenetics, and we calculate it based on the degree of methylation of multiple specific regions of human DNA. For previous research, we know that patients with ischemic stroke are biologically older than healthy individuals without stroke. On the other hand, white matter hyperintensities (WMH) observed in brain magnetic resonance images are an unspecific sign that has been associated with brain aging and also with the increased risk of stroke or dementia. It is unknown whether epigenetic biological age is associated with this sign of brain aging. In this manuscript, we interrogated the association between B-age and WMH volume and found that patients with high WMH burden are biologically older. Moreover, we found that 42.7% of the effects of chronological age on WMH can be explained by B-age, suggesting a role of epigenetics in WMH pathophysiology. Our study also generates a potential number of questions that might be addressed in further articles, such as whether this relationship depends on WMH location. In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both epigenetic (DNA methylation) and magnetic resonance imaging data. WMH were measured using a semi-automated method. B-age was calculated using two widely used methods: the Hannum and Horvath formulas. We used multiple linear regression models to interrogate the role of B-age on WMH volume after adjusting for chronological age (C-age) and other covariables. Average C-age of the sample was 68.4 (±11.8) and we observed a relatively high median WMH volume (median = 8.8 cm3, Q1–Q3 = 4.05–18.8). After adjusting for potential confounders, we observed a significant effect of B-ageHannum on WMH volume (βHannum = 0.023, p-value = 0.029) independently of C-age, which remained significant (βC-age = 0.021, p-value = 0.036). Finally, we performed a mediation analysis, which allowed us to discover that 42.7% of the effect of C-age on WMH is mediated by B-ageHannum. On the other hand, B-ageHoarvath showed no significant associations with WMH after being adjusted for C-age. In conclusion, we show for the first time that biological age, measured through DNA methylation, contributes substantially to explain WMH volumetric burden irrespective of chronological age. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort

Author

Medrano-Martorell, Santiago, primary, Capellades, Jaume, additional, Jiménez-Conde, Jordi, additional, González-Ortiz, Sofía, additional, Vilas-González, Marta, additional, Rodríguez-Campello, Ana, additional, Ois, Ángel, additional, Cuadrado-Godia, Elisa, additional, Avellaneda, Carla, additional, Fernández, Isabel, additional, Merino-Peña, Elisa, additional, Roquer, Jaume, additional, Martí-Fàbregas, Joan, additional, and Giralt-Steinhauer, Eva, additional

Published
2021
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22. Outcomes of a Contemporary Cohort of 536 Consecutive Patients With Acute Ischemic Stroke Treated With Endovascular Therapy

Author

Abilleira, Sònia, Cardona, Pere, Ribó, Marc, Millán, Mònica, Obach, Víctor, Roquer, Jaume, Cánovas, David, Martí-Fàbregas, Joan, Rubio, Francisco, Álvarez-Sabín, José, Dávalos, Antoni, Chamorro, Ángel, de Miquel, Maria Angeles, Tomasello, Alejandro, Castaño, Carlos, Macho, Juan M., Ribera, Aida, Gallofré, Miquel, Sanahuja, Jordi, Purroy, Francisco, Serena, Joaquín, Castellanos, Mar, Silva, Yolanda, van Eendenburg, Cecile, Pellisé, Anna, Ustrell, Xavier, Marés, Rafael, Baiges, Juanjo, Garcés, Moisés, Saura, Júlia, Soler Insa, Josep Maria, Aragonés, Josep Maria, Otermín, Pilar, Cocho, Dolores, Palomeras, Ernest, Pérez de la Ossa, Natalia, Gomis, Meritxell, López-Cancio, Elena, Dorado, Laura, Aleu, Aitzíber, García-Bermejo, Pablo, Rubiera, Marta, Santamarina, Esteban, Pagola, Jorge, Molina, Carlos, Coscojuela, Pilar, Quesada, Helena, Cano, Lluis, Aja, Lucia, Mora, Paloma, Cervera, Álvaro, Amaro, Sergio, Urra, Xabier, Blasco-Andaluz, Jordi, San Roman, Luis, Delgado-Mederos, Raquel, Dinia, Lavinia, Carrera-Giraldo, David, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Vivas, Elio, del Carmen Garcia, Maria, Estela, Jordi, Perendreu, Joan, Krupinski, Jerzy, Huertas-Folch, Sonia, Nicolás-Herrerias, M. Carme, Gómez-Choco, Manuel, García, Sonia, and Martínez, Raul

Published
2014
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23. A parsimonious score with a free web tool for predicting disability after an ischemic stroke: the Parsifal Score

Author

Instituto de Salud Carlos III, Fundació La Marató de TV3, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Muiño, Elena, Bustamante, Alejandro, Rodríguez-Campello, Ana, Gallego-Fabrega, Cristina, Ois, Ángel, Carrera, Caty, Cullell, Nàtalia, Torres-Águila, Nuria P., Cárcel-Márquez, Jara, Rubiera, M., Molina, Carlos A., Cuadrado-Godia, Elisa, Giralt-Steinhauer, Eva, Jiménez-Conde, Jordi, Montaner, Joan, Fernández-Cadenas, Israel, Roquer, Jaume, Instituto de Salud Carlos III, Fundació La Marató de TV3, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Muiño, Elena, Bustamante, Alejandro, Rodríguez-Campello, Ana, Gallego-Fabrega, Cristina, Ois, Ángel, Carrera, Caty, Cullell, Nàtalia, Torres-Águila, Nuria P., Cárcel-Márquez, Jara, Rubiera, M., Molina, Carlos A., Cuadrado-Godia, Elisa, Giralt-Steinhauer, Eva, Jiménez-Conde, Jordi, Montaner, Joan, Fernández-Cadenas, Israel, and Roquer, Jaume

Abstract

[Background] Most of the models to predict prognosis after an ischemic stroke include complex mathematical equations or too many variables, making them difficult to use in the daily clinic. We want to predict disability 3 months after an ischemic stroke in an independent patient not receiving recanalization treatment within the first 24 h, using a minimum set of variables and an easy tool to facilitate its implementation. As a secondary aim, we calculated the capacity of the score to predict an excellent/devastating outcome and mortality., [Methods] Eight hundred and forty-four patients were evaluated. A multivariable ordinal logistic regression was used to obtain the score. The Modified Rankin Scale (mRS) was used to estimate disability at the third month. The results were replicated in another independent cohort (378 patients). The “polr” function of R was used to perform the regression, stratifying the sample into seven groups with different cutoffs (from mRS 0 to 6)., [Results] The Parsifal score was generated with: age, previous mRS, initial NIHSS, glycemia on admission, and dyslipidemia. This score predicts disability with an accuracy of 80–76% (discovery–replication cohorts). It has an AUC of 0.86 in the discovery and replication cohort. The specificity was 90–80% (discovery–replication cohorts); while, the sensitivity was 64–74% (discovery–replication cohorts). The prediction of an excellent or devastating outcome, as well as mortality, obtained good discrimination with AUC > 0.80., [Conclusions] The Parsifal Score is a model that predicts disability at the third month, with only five variables, with good discrimination and calibration, and being replicated in an independent cohort.

Published
2020

24. Identification of 20 novel loci associated with ischaemic stroke. Epigenome-wide association study

Author

Soriano-Tárraga, Carolina, Lazcano, Uxue, Giralt-Steinhauer, Eva, Avellaneda-Gómez, Carla, Ois, Ángel, Rodríguez-Campello, Ana, Soriano-Tárraga, Carolina, Lazcano, Uxue, Giralt-Steinhauer, Eva, Avellaneda-Gómez, Carla, Ois, Ángel, and Rodríguez-Campello, Ana

Abstract

DNA methylation is dynamic, varies throughout the life course, and its levels are influenced by lifestyle and environmental factors, as well as by genetic variation. The leading genetic variants at stroke risk loci identified to date explain roughly 1–2% of stroke heritability. Most of these single nucleotide polymorphisms are situated within a regulatory sequence marked by DNase I hypersensitivity sites, which would indicate involvement of an epigenetic mechanism. To detect epigenetic variants associated with stroke occurrence and stroke subtypes. A two-stage case–control epigenome-wide association study was designed. The discovery sample with 401 samples included 218 ischaemic stroke (IS) patients, assessed at Hospital del Mar (Barcelona, Spain) and 183 controls from the REGICOR cohort. In two independent samples (N = 226 and N = 166), we replicated 22 CpG sites differentially methylated in IS in 21 loci, including 2 CpGs in locus ZFHX3, which includes known genetic variants associated with stroke. The pathways associated with these loci are inflammation and angiogenesis. The meta-analysis identified 384 differentially methylated CpGs, including loci of known stroke and vascular risk genetic variants, enriched by loci involved in lipid metabolism, adipogenesis, circadian clock, and glycolysis pathways. We identified a set of 22 CpGs in 21 loci associated with IS. Our analysis suggests that DNA methylation changes may contribute to orchestrating gene expression that contributes to IS.

Published
2020

26. Inflammatory Response of Ischemic Tolerance in Circulating Plasma: Preconditioning-Induced by Transient Ischemic Attack (TIA) Phenomena in Acute Ischemia Patients (AIS)

Author

Colàs-Campàs, Laura, primary, Farre, Joan, additional, Mauri-Capdevila, Gerard, additional, Molina-Seguín, Jessica, additional, Aymerich, Núria, additional, Ois, Ángel, additional, Roquer, Jaume, additional, Tur, Silvia, additional, García-Carreira, María del Carmen, additional, Martí-Fàbregas, Joan, additional, Cruz-Culebras, Antonio, additional, Segura, Tomás, additional, Arque, Gloria, additional, and Purroy, Francisco, additional

Published
2020
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27. Identification of 20 novel loci associated with ischaemic stroke. Epigenome-wide association study

Author

Soriano-Tárraga, Carolina, primary, Lazcano, Uxue, additional, Giralt-Steinhauer, Eva, additional, Avellaneda-Gómez, Carla, additional, Ois, Ángel, additional, Rodríguez-Campello, Ana, additional, Cuadrado-Godia, Elisa, additional, Gómez-González, Alejandra, additional, Fernández-Sanlés, Alba, additional, Elosua, Roberto, additional, Fernández-Cadenas, Israel, additional, Cullell, Natalia, additional, Montaner, Joan, additional, Moran, Sebastian, additional, Esteller, Manel, additional, Jiménez-Conde, Jordi, additional, and Roquer, Jaume, additional

Published
2020
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28. Identification of 20 novel loci associated to ischemic stroke. Epigenome-Wide Association Study

Author

Soriano-Tárraga, Carolina, primary, Lazcano, Uxue, additional, Giralt-Steinhauer, Eva, additional, Avellaneda-Gómez, Carla, additional, Ois, Ángel, additional, Rodríguez-Campello, Ana, additional, Cuadrado-Godia, Elisa, additional, Gomez-Gonzalez, Alejandra, additional, Fernández-Sanlés, Alba, additional, Elosua, Roberto, additional, Fernández-Cadenas, Israel, additional, Cullell, Natalia, additional, Montaner, Joan, additional, Moran, Sebastian, additional, Esteller, Manel, additional, Jiménez-Conde, Jordi, additional, and Roquer, Jaume, additional

Published
2019
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29. Association of residential air pollution, noise, and greenspace with initial ischemic stroke severity.

Author

Vivanco-Hidalgo, Rosa Maria, primary, Avellaneda-Gómez, Carla, additional, Dadvand, Payam, additional, Cirach, Marta, additional, Ois, Ángel, additional, Gómez González, Alejandra, additional, Rodriguez-Campello, Ana, additional, de Ceballos, Pablo, additional, Basagaña, Xavier, additional, Zabalza, Ana, additional, Cuadrado-Godia, Elisa, additional, Sunyer, Jordi, additional, Roquer, Jaume, additional, and Wellenius, Gregory A., additional

Published
2019
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30. A Genome-Wide Meta-Analysis

Author

Mola-Caminal, Marina, Carrera, Caty, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Díaz-Navarro, Rosa M., Tur, Sílvia, Jiménez, Carmen, Medina-Dols, Aina, Cullell, Nàtalia, Torres-Águila, Nuria P., Muiño, Elena, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Vivanco-Hidalgo, Rosa M., Hernández-Guillamón, Mar, Solé, Montse, Delgado, Pilar, Bustamante, Alejandro, García-Berrocoso, Teresa, Mendióroz, Maite, Castellanos, Mar, Serena, Joaquín, Marti-Fabregas, Joan, Segura, Tomás, Serrano-Heras, Gemma, Obach, Víctor, Ribó, Marc, Molina, Carlos A., Álvarez-Sabín, José, Palomeras, Ernest, Freijo, Mar, Font, Maria A., Rosand, Jonathan, Rost, Natalia S., Gallego-Fabrega, Cristina, Lee, Jin-Moo, Heitsch, Laura, Ibáñez, Laura, Cruchaga, Carlos, Phuah, Chia-Ling, Lemmens, Robin, Thijs, Vincent, Lindgren, Arne, Maguire, Jane, Rannikmae, Kistiina, Sudlow, Catherine L., Jern, Christina, Stanne, Tara M., Lorentzen, Erik, Muñoz-Narbona, Lucía, Dávalos, Antonio, López-Cancio, Elena, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., Mitchell, Braxton D., Montaner, Joan, Roquer, Jaume, Krupinski, Jurek, Estivill, Xavier, Rabionet, Raquel, Vives-Bauzá, Cristòfol, Fernández-Cadenas, Israel, Jiménez-Conde, Jordi, Fundació La Marató de TV3, Instituto de Salud Carlos III, National Institutes of Health (US), and National Institute of Neurological Disorders and Stroke (US)

Subjects
Allele, Genome-wide association study, Ischemic stroke, Genetic loci, cardiovascular diseases, Genetic variant
Abstract

[Rationale] Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome., [Objective] Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date., [Methods and Results] A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70×10−9)., [Conclusions] Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci., Genetic contribution to functional outcome and disability after stroke (GODS) project, Fundació Marató-TV3 Grant 2011 (76/C/2011), Recercaixa’13; Generación Project, Instituto de Salud Carlos III; GENISIS (Genetics of Early Neurological InStability After Ischemic Stroke) project, National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke Stroke Genetics Network (SiGN) Project, NIH.

Published
2019

31. A Genome-Wide Meta-Analysis

Author

Mola-Caminal, Marina, Carrera, Caty, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Díaz-Navarro, Rosa M., Tur, Sílvia, Jiménez, Carmen, Medina-Dols, Aina, Cullell, Nàtalia, Torres-Águila, Nuria P., Muiño, Elena, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Vivanco-Hidalgo, Rosa M., Hernández-Guillamón, Mar, Solé, Montse, Delgado, Pilar, Bustamante, Alejandro, García-Berrocoso, Teresa, Mendióroz, Maite, Castellanos, Mar, Serena, Joaquín, Marti-Fabregas, Joan, Segura, Tomás, Serrano-Heras, Gemma, Obach, Víctor, Ribó, Marc, Molina, Carlos A., Álvarez-Sabín, José, Palomeras, Ernest, Freijo, Mar, Font, Maria A., Rosand, Jonathan, Rost, Natalia S., Gallego-Fabrega, Cristina, Lee, Jin-Moo, Heitsch, Laura, Ibáñez, Laura, Cruchaga, Carlos, Phuah, Chia-Ling, Lemmens, Robin, Thijs, Vincent, Lindgren, Arne, Maguire, Jane, Rannikmae, Kistiina, Sudlow, Catherine L., Jern, Christina, Stanne, Tara M., Lorentzen, Erik, Muñoz-Narbona, Lucía, Dávalos, Antonio, López-Cancio, Elena, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., Mitchell, Braxton D., Montaner, Joan, Roquer, Jaume, Krupinski, Jurek, Estivill, Xavier, Rabionet, Raquel, Vives-Bauzá, Cristòfol, Fernández-Cadenas, Israel, Jiménez-Conde, Jordi, Fundació La Marató de TV3, Instituto de Salud Carlos III, National Institutes of Health (US), and National Institute of Neurological Disorders and Stroke (US)

Subjects
genetic variant, genome-wide association study, Tight Junction Proteins, allele, Stroke Rehabilitation, genetic loci, Recovery of Function, Polymorphism, Single Nucleotide, Brain Ischemia, Stroke, Disability Evaluation, Phenotype, Treatment Outcome, Gene Frequency, Risk Factors, ischemic stroke, Humans, Genetic Predisposition to Disease, Genome-Wide Association Study
Abstract

[Rationale] Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome. [Objective] Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date. [Methods and Results] A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70×10−9). [Conclusions] Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci. Genetic contribution to functional outcome and disability after stroke (GODS) project, Fundació Marató-TV3 Grant 2011 (76/C/2011), Recercaixa’13; Generación Project, Instituto de Salud Carlos III; GENISIS (Genetics of Early Neurological InStability After Ischemic Stroke) project, National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke Stroke Genetics Network (SiGN) Project, NIH.

Published
2018

32. Factors associated with poor anticoagulation control with vitamin K antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study

Author

Contreras Muruaga, M.M., primary, Reig, G., additional, Vivancos, J., additional, González, A., additional, Cardona, P., additional, Ramírez-Moreno, J.M., additional, Martí-Fábregas, J., additional, Suárez Fernández, C., additional, Pose, Antonio, additional, Díaz, José Antonio, additional, Rodríguez, Manuel, additional, Pena, Marta, additional, Arias, Susana, additional, Larrosa, Davinia, additional, González, Álvaro, additional, Rodríguez, Elisa, additional, González, Montserrat, additional, Fernández, Dolores, additional, Barbagelata, Cristina, additional, Raña, Natividad, additional, Freire, Santiago, additional, Cerqueiro, J. Manuel, additional, Guerrero, Héctor, additional, Ramos, Laura, additional, Álvarez, Leticia, additional, de Lis, José M., additional, Caro, Carmen, additional, Seijo, Manuel, additional, Mederer, Susana, additional, de Zarraga, Miguel Alberto, additional, Ferreiro, José, additional, Terrero, José M., additional, Arias, Mónica, additional, Pérez, Roberto, additional, Sánchez, Joaquín, additional, Maciñeiras, José, additional, Fernández, Julián, additional, Jaén, Fernando, additional, Esteva, David, additional, Zamora, Mónica, additional, Navarrete, Nuria, additional, García, Javier, additional, Mérida, Luis, additional, Corrales, Miguel Ángel, additional, Quirós, Raúl, additional, Cantero, Jesús, additional, Barrero, Francisco Javier, additional, Villegas, Inmaculada, additional, Castro, José, additional, Foronda, Jesús, additional, Carrillo, Dionisio, additional, Vega, Jesús, additional, Trujillo, José Antonio, additional, Montero, Manuel, additional, Jurado, Ana, additional, Sánchez, Carlos, additional, Agüera-Morales, Eduardo, additional, Sánchez, María, additional, Durán, Purificación, additional, Fernández de la Puerta, Rafael, additional, Pérez de la Blanca, María, additional, Martínez, María Paz, additional, Fernández, Óscar, additional, Tamayo, José Antonio, additional, Bustamante, Rafael, additional, Serrano, Pedro Jesús, additional, Arjona, Antonio, additional, Fernández, Javier, additional, Payan, Manuel, additional, Gómez, Ricardo, additional, Peña, Daniel, additional, Cabrerizo, Enrique, additional, Salgado, Fernando, additional, Ivanova Georgieva, Radka, additional, Gil-Núñez, Antonio, additional, Bello, Elena, additional, Díaz, Fernando, additional, Medina, Antonio, additional, Castellano, Ana, additional, Miranda, Yesica, additional, Fabre, Óscar, additional, García Polo, Iluminada, additional, Ibáñez, Patricia, additional, Sainz, Clara, additional, Sierra, Fernando, additional, Aragón, Esther, additional, Díaz, Jaime, additional, Aguilar, Fernando, additional, Ortega, María Ángeles, additional, Egido, José Antonio, additional, Pontes, José Carlos, additional, García, Miguel Ángel, additional, Cabrera, Francisco, additional, Batalla, Blanca, additional, Culla, Alex, additional, Molina, Carlos, additional, Flores, Alan, additional, Seró, Laia, additional, Muchada, Marian, additional, Meler, Pilar, additional, Boned-Riera, Sandra, additional, Cánovas, David, additional, Estela, Jordi, additional, Font, Juli, additional, Purroy, Francisco, additional, Benabdelhak, Ikram, additional, Sanahuja, Jordi, additional, Roquer, Jaume, additional, Rodríguez, Ana, additional, Ois, Ángel, additional, Cuadrado, Elisa, additional, Jiménez, Jordi, additional, Nogués, Xavier, additional, Kuprinski, Jerzy, additional, German, Antoni, additional, Irigoyen, Daniel, additional, Cara, Juan José, additional, Font, Maria Àngels, additional, Huertas, Sonia, additional, Martínez-Domeño, Alejandro, additional, Arroyo, Juan Antonio, additional, Delgado-Mederos, Raquel, additional, Gómez-Choco, Manuel Jesús, additional, Mengual, Juan José, additional, García, Sonia M., additional, Castellanos, M. del Mar, additional, van Eedenburg, Cecile, additional, Cañas, Imma, additional, Espinosa, Jordi, additional, Montull, Santiago, additional, Quesada, Helena, additional, Ustrell, Xavier, additional, Homedes, Christian, additional, Navalpotro, Irene, additional, Casanova, Jordi, additional, Lago, Aida Pilar, additional, Morata, Carmen, additional, Gorriz, David, additional, Moreno, Iván, additional, Tembl, José, additional, Ponz, Alejandro, additional, Fonseca, M. José, additional, Chamarro, Raquel, additional, Gil, Rosario, additional, Oliver, Vicente, additional, Pampliega, Ana, additional, Artero, Arturo, additional, Puchades, Francesc, additional, Landete, Lamberto, additional, Vilar, Carlos, additional, Jiménez, Carmen, additional, Vives, Bárbara, additional, Moragues, M. Dolores, additional, Díaz, Rosa, additional, Tur, Silvia, additional, Escribano, José Bernardo, additional, Lucas, César, additional, Martínez, Francisco, additional, Pons, José Miguel, additional, Romero, Amparo, additional, García, David, additional, Pérez, José, additional, Villaverde, Ramón, additional, Martínez, Salvadora, additional, Rodríguez, Aida, additional, Tejero, Carlos, additional, Pérez, Cristina, additional, Mostacero, Enrique, additional, Fernández, Covadonga, additional, Luna, Alain, additional, Pérez, Tomás, additional, González, Félix, additional, de Arce, Ana, additional, Martínez, Maite, additional, Díez, Noemí, additional, Gállego, Jaime, additional, Zandio, Beatriz, additional, Herrera, María, additional, Aymerich, Nuria, additional, Muñoz, Roberto, additional, Marta, Javier, additional, Artal, Jorge, additional, Errea, José M., additional, Timiraos, Juan José, additional, Moreno, M. Pilar, additional, Freijo, Mar, additional, García, Juan Manuel, additional, Gil, M. Carmen, additional, Revilla, M. Ángeles, additional, Palacio, Enrique, additional, Vázquez, José Luis, additional, Bestué, María, additional, Latorre, Ana, additional, Calvo, Eva, additional, Ballester, Laura, additional, Serrano, Marta, additional, Juega, Jesús M., additional, López, M. Ángeles, additional, Irimia, Pablo, additional, Imaz, Laura, additional, Fuentes, Blanca, additional, Sanz, Borja Enrique, additional, Beltrán, Luis, additional, Ruiz, Gerardo, additional, Martínez, Patricia, additional, Sánchez, Demetrio, additional, Barroso, Emilio, additional, Molina, Igor, additional, Budiño, Marco Antonio, additional, Masjuan, Jaime, additional, de Felipe, Alicia, additional, Matute, Consuelo, additional, Tejada, Javier, additional, Morán, Alberto, additional, Fernández, Esther, additional, Riveira, M. del Carmen, additional, Carnedo, Joaquín, additional, Manquillo, Antonio, additional, González, Raquel, additional, Fernández, José Carlos, additional, Guillan, Marta, additional, Yebra, Miguel, additional, Trejo, José M., additional, Saiz, Jesús, additional, Martínez-Acitores, Juan Carlos, additional, Bravo, Yolanda, additional, Arenillas, Juan Francisco, additional, Calleja, Ana, additional, Cortijo, Elisa, additional, Reyes, Javier, additional, López, Luis, additional, Muñoz, Pedro Luis, additional, Fidalgo, M. Ángeles, additional, Hernández, Jacinto, additional, Gómez, José Carlos, additional, Morán, José Carlos, additional, Gonzalo, Sonia, additional, Marrero, Jorge, additional, Satué, José Ángel, additional, Belinchón, Juan Carlos, additional, Moniche, Francisco, additional, Calderón, Enrique, additional, Escudero, Irene, additional, de la Torre, Javier, additional, Casado, Ignacio, additional, Antón, Joaquín, additional, Portilla, Juan Carlos, additional, Luengo, Juan, additional, Rosal, Joan, additional, Calzado, Elena, additional, Anglada, Juan Carlos, additional, Girón, Juan, additional, Ramírez, José M., additional, Pijierro, Agustín, additional, Roa, Ana, additional, Romero, Jorge, additional, Aguayo, Mariano, additional, Borrachero, Cristina, additional, Sanz, Gema, additional, Gómez, M. José, additional, Rico, Miguel Ángel, additional, Cayon, Antonio, additional, Carmona, Eduardo, additional, Cerro, Román, additional, López, Rafael, additional, Aguirre, Alfonso, additional, Lozano, Francisco, additional, and Rivera, José M., additional

Published
2018
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33. Factores asociados al mal control de la anticoagulación con antivitamina K en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN

Author

Contreras Muruaga, M.M., primary, Reig, G., additional, Vivancos, J., additional, González, A., additional, Cardona, P., additional, Ramírez-Moreno, J.M., additional, Martí-Fábregas, J., additional, Suárez Fernández, C., additional, Pose, Antonio, additional, Díaz, José Antonio, additional, Rodríguez, Manuel, additional, Pena, Marta, additional, Arias, Susana, additional, Larrosa, Davinia, additional, González, Álvaro, additional, Rodríguez, Elisa, additional, González, Montserrat, additional, Fernández, Dolores, additional, Barbagelata, Cristina, additional, Raña, Natividad, additional, Freire, Santiago, additional, Cerqueiro, J. Manuel, additional, Guerrero, Héctor, additional, Ramos, Laura, additional, Álvarez, Leticia, additional, de Lis, José M., additional, Caro, Carmen, additional, Seijo, Manuel, additional, Mederer, Susana, additional, de Zarraga, Miguel Alberto, additional, Ferreiro, José, additional, Terrero, José M., additional, Arias, Mónica, additional, Pérez, Roberto, additional, Sánchez, Joaquín, additional, Maciñeiras, José, additional, Fernández, Julián, additional, Jaén, Fernando, additional, Esteva, David, additional, Zamora, Mónica, additional, Navarrete, Nuria, additional, García, Javier, additional, Mérida, Luis, additional, Corrales, Miguel Ángel, additional, Quirós, Raúl, additional, Cantero, Jesús, additional, Barrero, Francisco Javier, additional, Villegas, Inmaculada, additional, Castro, José, additional, Foronda, Jesús, additional, Carrillo, Dionisio, additional, Vega, Jesús, additional, Trujillo, José Antonio, additional, Montero, Manuel, additional, Jurado, Ana, additional, Sánchez, Carlos, additional, Agüera-Morales, Eduardo, additional, Sánchez, María, additional, Durán, Purificación, additional, Fernández de la Puerta, Rafael, additional, Pérez de la Blanca, María, additional, Martínez, María Paz, additional, Fernández, Óscar, additional, Tamayo, José Antonio, additional, Bustamante, Rafael, additional, Serrano, Pedro Jesús, additional, Arjona, Antonio, additional, Fernández, Javier, additional, Payan, Manuel, additional, Gómez, Ricardo, additional, Peña, Daniel, additional, Cabrerizo, Enrique, additional, Salgado, Fernando, additional, Ivanova Georgieva, Radka, additional, Gil-Núñez, Antonio, additional, Bello, Elena, additional, Díaz, Fernando, additional, Medina, Antonio, additional, Castellano, Ana, additional, Miranda, Yesica, additional, Fabre, Óscar, additional, García Polo, Iluminada, additional, Ibáñez, Patricia, additional, Sainz, Clara, additional, Sierra, Fernando, additional, Aragón, Esther, additional, Díaz, Jaime, additional, Aguilar, Fernando, additional, Ortega, María Ángeles, additional, Egido, José Antonio, additional, Pontes, José Carlos, additional, García, Miguel Ángel, additional, Cabrera, Francisco, additional, Batalla, Blanca, additional, Culla, Alex, additional, Molina, Carlos, additional, Flores, Alan, additional, Seró, Laia, additional, Muchada, Marian, additional, Meler, Pilar, additional, Boned-Riera, Sandra, additional, Cánovas, David, additional, Estela, Jordi, additional, Font, Juli, additional, Purroy, Francisco, additional, Benabdelhak, Ikram, additional, Sanahuja, Jordi, additional, Roquer, Jaume, additional, Rodríguez, Ana, additional, Ois, Ángel, additional, Cuadrado, Elisa, additional, Jiménez, Jordi, additional, Nogués, Xavier, additional, Kuprinski, Jerzy, additional, German, Antoni, additional, Irigoyen, Daniel, additional, Cara, Juan José, additional, Font, Maria Àngels, additional, Huertas, Sonia, additional, Martínez-Domeño, Alejandro, additional, Arroyo, Juan Antonio, additional, Delgado-Mederos, Raquel, additional, Gómez-Choco, Manuel Jesús, additional, Mengual, Juan José, additional, García, Sonia M., additional, Castellanos, M. del Mar, additional, van Eedenburg, Cecile, additional, Cañas, Imma, additional, Espinosa, Jordi, additional, Montull, Santiago, additional, Quesada, Helena, additional, Ustrell, Xavier, additional, Homedes, Christian, additional, Navalpotro, Irene, additional, Casanova, Jordi, additional, Lago, Aida Pilar, additional, Morata, Carmen, additional, Gorriz, David, additional, Moreno, Iván, additional, Tembl, José, additional, Ponz, Alejandro, additional, Fonseca, M. José, additional, Chamarro, Raquel, additional, Gil, Rosario, additional, Oliver, Vicente, additional, Pampliega, Ana, additional, Artero, Arturo, additional, Puchades, Francesc, additional, Landete, Lamberto, additional, Vilar, Carlos, additional, Jiménez, Carmen, additional, Vives, Bárbara, additional, Moragues, M. Dolores, additional, Díaz, Rosa, additional, Tur, Silvia, additional, Escribano, José Bernardo, additional, Lucas, César, additional, Martínez, Francisco, additional, Pons, José Miguel, additional, Romero, Amparo, additional, García, David, additional, Pérez, José, additional, Villaverde, Ramón, additional, Martínez, Salvadora, additional, Rodríguez, Aida, additional, Tejero, Carlos, additional, Pérez, Cristina, additional, Mostacero, Enrique, additional, Fernández, Covadonga, additional, Luna, Alain, additional, Pérez, Tomás, additional, González, Félix, additional, de Arce, Ana, additional, Martínez, Maite, additional, Díez, Noemí, additional, Gállego, Jaime, additional, Zandio, Beatriz, additional, Herrera, María, additional, Aymerich, Nuria, additional, Muñoz, Roberto, additional, Marta, Javier, additional, Artal, Jorge, additional, Errea, José M., additional, Timiraos, Juan José, additional, Moreno, M. Pilar, additional, Freijo, Mar, additional, García, Juan Manuel, additional, Gil, M. Carmen, additional, Revilla, M. Ángeles, additional, Palacio, Enrique, additional, Vázquez, José Luis, additional, Bestué, María, additional, Latorre, Ana, additional, Calvo, Eva, additional, Ballester, Laura, additional, Serrano, Marta, additional, Juega, Jesús M., additional, López, M. Ángeles, additional, Irimia, Pablo, additional, Imaz, Laura, additional, Fuentes, Blanca, additional, Sanz, Borja Enrique, additional, Beltrán, Luis, additional, Ruiz, Gerardo, additional, Martínez, Patricia, additional, Sánchez, Demetrio, additional, Barroso, Emilio, additional, Molina, Igor, additional, Budiño, Marco Antonio, additional, Masjuan, Jaime, additional, de Felipe, Alicia, additional, Matute, Consuelo, additional, Tejada, Javier, additional, Morán, Alberto, additional, Fernández, Esther, additional, Riveira, M. del Carmen, additional, Carnedo, Joaquín, additional, Manquillo, Antonio, additional, González, Raquel, additional, Fernández, José Carlos, additional, Guillan, Marta, additional, Yebra, Miguel, additional, Trejo, José M., additional, Saiz, Jesús, additional, Martínez-Acitores, Juan Carlos, additional, Bravo, Yolanda, additional, Arenillas, Juan Francisco, additional, Calleja, Ana, additional, Cortijo, Elisa, additional, Reyes, Javier, additional, López, Luis, additional, Muñoz, Pedro Luis, additional, Fidalgo, M. Ángeles, additional, Hernández, Jacinto, additional, Gómez, José Carlos, additional, Morán, José Carlos, additional, Gonzalo, Sonia, additional, Marrero, Jorge, additional, Satué, José Ángel, additional, Belinchón, Juan Carlos, additional, Moniche, Francisco, additional, Calderón, Enrique, additional, Escudero, Irene, additional, de la Torre, Javier, additional, Casado, Ignacio, additional, Antón, Joaquín, additional, Portilla, Juan Carlos, additional, Luengo, Juan, additional, Rosal, Joan, additional, Calzado, Elena, additional, Anglada, Juan Carlos, additional, Girón, Juan, additional, Ramírez, José M., additional, Pijierro, Agustín, additional, Roa, Ana, additional, Romero, Jorge, additional, Aguayo, Mariano, additional, Borrachero, Cristina, additional, Sanz, Gema, additional, Gómez, M. José, additional, Rico, Miguel Ángel, additional, Cayon, Antonio, additional, Carmona, Eduardo, additional, Cerro, Román, additional, López, Rafael, additional, Aguirre, Alfonso, additional, Lozano, Francisco, additional, and Rivera., José M., additional

Published
2018
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34. Underdiagnosis of Unilateral Spatial Neglect in stroke unit

Author

Puig-Pijoan, Albert, primary, Giralt-Steinhauer, Eva, additional, Zabalza de Torres, Ana, additional, Manero Borràs, Rosa Maria, additional, Sánchez-Benavides, Gonzalo, additional, García Escobar, Greta, additional, Pérez Enríquez, Carmen, additional, Gómez-González, Alejandra, additional, Ois, Ángel, additional, Rodríguez-Campello, Ana, additional, Cuadrado-Godía, Elisa, additional, Jiménez-Conde, Jordi, additional, Peña-Casanova, Jordi, additional, and Roquer, Jaume, additional

Published
2018
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36. Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study

Author

Pulit, Sara L, primary, McArdle, Patrick F, additional, Wong, Quenna, additional, Malik, Rainer, additional, Gwinn, Katrina, additional, Achterberg, Sefanja, additional, Algra, Ale, additional, Amouyel, Philippe, additional, Anderson, Christopher D, additional, Arnett, Donna K, additional, Arsava, Ethem Murat, additional, Attia, John, additional, Ay, Hakan, additional, Bartz, Traci M, additional, Battey, Thomas, additional, Benavente, Oscar R, additional, Bevan, Steve, additional, Biffi, Alessandro, additional, Bis, Joshua C, additional, Blanton, Susan H, additional, Boncoraglio, Giorgio B, additional, Brown, Robert D, additional, Burgess, Annette I, additional, Carrera, Caty, additional, Chapman Smith, Sherita N, additional, Chasman, Daniel I, additional, Chauhan, Ganesh, additional, Chen, Wei-Min, additional, Cheng, Yu-Ching, additional, Chong, Michael, additional, Cloonan, Lisa K, additional, Cole, John W, additional, Cotlarciuc, Ioana, additional, Cruchaga, Carlos, additional, Cuadrado-Godia, Elisa, additional, Dave, Tushar, additional, Dawson, Jesse, additional, Debette, Stéphanie, additional, Delavaran, Hossein, additional, Dell, Cameron A, additional, Dichgans, Martin, additional, Doheny, Kimberly F, additional, Dong, Chuanhui, additional, Duggan, David J, additional, Engström, Gunnar, additional, Evans, Michele K, additional, Pallejà, Xavier Estivill, additional, Faul, Jessica D, additional, Fernández-Cadenas, Israel, additional, Fornage, Myriam, additional, Frossard, Philippe M, additional, Furie, Karen, additional, Gamble, Dale M, additional, Gieger, Christian, additional, Giese, Anne-Katrin, additional, Giralt-Steinhauer, Eva, additional, González, Hector M, additional, Goris, An, additional, Gretarsdottir, Solveig, additional, Grewal, Raji P, additional, Grittner, Ulrike, additional, Gustafsson, Stefan, additional, Han, Buhm, additional, Hankey, Graeme J, additional, Heitsch, Laura, additional, Higgins, Peter, additional, Hochberg, Marc C, additional, Holliday, Elizabeth, additional, Hopewell, Jemma C, additional, Horenstein, Richard B, additional, Howard, George, additional, Ikram, M Arfan, additional, Ilinca, Andreea, additional, Ingelsson, Erik, additional, Irvin, Marguerite R, additional, Jackson, Rebecca D, additional, Jern, Christina, additional, Conde, Jordi Jiménez, additional, Johnson, Julie A, additional, Jood, Katarina, additional, Kahn, Muhammad S, additional, Kaplan, Robert, additional, Kappelle, L Jaap, additional, Kardia, Sharon L R, additional, Keene, Keith L, additional, Kissela, Brett M, additional, Kleindorfer, Dawn O, additional, Koblar, Simon, additional, Labovitz, Daniel, additional, Launer, Lenore J, additional, Laurie, Cathy C, additional, Laurie, Cecelia A, additional, Lee, Cue Hyunkyu, additional, Lee, Jin-Moo, additional, Lehm, Manuel, additional, Lemmens, Robin, additional, Levi, Christopher, additional, Leys, Didier, additional, Lindgren, Arne, additional, Longstreth, W T, additional, Maguire, Jane, additional, Manichaikul, Ani, additional, Markus, Hugh S, additional, McClure, Leslie A, additional, McDonough, Caitrin W, additional, Meisinger, Christa, additional, Melander, Olle, additional, Meschia, James F, additional, Mola-Caminal, Marina, additional, Montaner, Joan, additional, Mosley, Thomas H, additional, Müller-Nurasyid, Martina, additional, Nalls, Mike A, additional, O'Connell, Jeffrey R, additional, O'Donnell, Martin, additional, Ois, ángel, additional, Papanicolaou, George J, additional, Paré, Guillaume, additional, Peddareddygari, Leema Reddy, additional, Pedersén, Annie, additional, Pera, Joanna, additional, Peters, Annette, additional, Poole, Deborah, additional, Psaty, Bruce M, additional, Rabionet, Raquel, additional, Raffeld, Miriam R, additional, Rannikmäe, Kristiina, additional, Rasheed, Asif, additional, Redfors, Petra, additional, Reiner, Alex P, additional, Rexrode, Kathryn, additional, Ribasés, Marta, additional, Rich, Stephen S, additional, Robberecht, Wim, additional, Rodriguez-Campello, Ana, additional, Rolfs, Arndt, additional, Roquer, Jaume, additional, Rose, Lynda M, additional, Rosenbaum, Daniel, additional, Rost, Natalia S, additional, Rothwell, Peter M, additional, Rundek, Tatjana, additional, Ryan, Kathleen A, additional, Sacco, Ralph L, additional, Sale, Michèle M, additional, Saleheen, Danish, additional, Salomaa, Veikko, additional, Sánchez-Mora, Cristina, additional, Schmidt, Carsten Oliver, additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Schürks, Markus, additional, Scott, Rodney, additional, Segal, Helen C, additional, Seiler, Stephan, additional, Seshadri, Sudha, additional, Sharma, Pankaj, additional, Shuldiner, Alan R, additional, Silver, Brian, additional, Slowik, Agnieszka, additional, Smith, Jennifer A, additional, Söderholm, Martin, additional, Soriano, Carolina, additional, Sparks, Mary J, additional, Stanne, Tara, additional, Stefansson, Kari, additional, Stine, O Colin, additional, Strauch, Konstantin, additional, Sturm, Jonathan, additional, Sudlow, Cathie LM, additional, Tajuddin, Salman M, additional, Talbert, Robert L, additional, Tatlisumak, Turgut, additional, Thijs, Vincent, additional, Thorleifsson, Gudmar, additional, Thorsteindottir, Unnur, additional, Tiedt, Steffen, additional, Traylor, Matthew, additional, Trompet, Stella, additional, Valant, Valerie, additional, Waldenberger, Melanie, additional, Walters, Matthew, additional, Wang, Liyong, additional, Wassertheil-Smoller, Sylvia, additional, Weir, David R, additional, Wiggins, Kerri L, additional, Williams, Stephen R, additional, Wloch-Kopec, Dorota, additional, Woo, Daniel, additional, Woodfield, Rebecca, additional, Wu, Ona, additional, Xu, Huichun, additional, Zonderman, Alan B, additional, Worrall, Bradford B, additional, de Bakker, Paul IW, additional, Kittner, Steven J, additional, Mitchell, Braxton D, additional, Rosand, Jonathan, additional, Pulit, Sara L, additional, Sudlow, Cathie L M, additional, Worrall, Bradford B Worrall, additional, Arnett, Donna K Arnett, additional, Benavente, Oscar, additional, and Wasssertheil-Smoller, Sylvia, additional

Published
2016
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37. New-Onset Paroxysmal Atrial Fibrillation Diagnosis in Ischemic Stroke Patients

Author

Giralt-Steinhauer, Eva, primary, Cuadrado-Godia, Elisa, additional, Soriano-Tárraga, Carolina, additional, Ois, Ángel, additional, Jiménez-Conde, Jordi, additional, Rodríguez-Campello, Ana, additional, Gómez-González, Alejandra, additional, Muiño-Acuña, Elena, additional, Subirana-Cachinero, Isaac, additional, and Roquer, Jaume, additional

Published
2015
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39. Dietary Habits in Patients with Ischemic Stroke: A Case-Control Study

Author

Rodríguez-Campello, Ana, primary, Jiménez-Conde, Jordi, additional, Ois, Ángel, additional, Cuadrado-Godia, Elisa, additional, Giralt-Steinhauer, Eva, additional, Schroeder, Helmut, additional, Romeral, Gemma, additional, Llop, Mireia, additional, Soriano-Tárraga, Carolina, additional, Garralda-Anaya, Montserrat, additional, and Roquer, Jaume, additional

Published
2014
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40. Factores asociados al mal control de la anticoagulación con antivitaminaK en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN

Author

Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., Suárez Fernández, C., Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, and Rivera., José M.

Abstract

Identificar los factores asociados con el mal control de la anticoagulación con antagonistas de la vitaminaK (AVK) en pacientes con fibrilación auricular no valvular (FANV) atendidos en consultas de Neurología y Medicina Interna de España.

Published
2018
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43. Global DNA Methylation of Ischemic Stroke Subtypes.

Author

Soriano-Tárraga, Carolina, Jiménez-Conde, Jordi, Giralt-Steinhauer, Eva, Mola, Marina, Ois, Ángel, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Fernández-Cadenas, Israel, Carrera, Caty, Montaner, Joan, Elosua, Roberto, and Roquer, Jaume

Subjects
DNA methylation, ISCHEMIA, STROKE, MORTALITY, EPIDEMIOLOGY, EPIGENETICS, CARDIOVASCULAR diseases
Abstract

Ischemic stroke (IS), a heterogeneous multifactorial disorder, is among the leading causes of mortality and long-term disability in the western world. Epidemiological data provides evidence for a genetic component to the disease, but its epigenetic involvement is still largely unknown. Epigenetic mechanisms, such as DNA methylation, change over time and may be associated with aging processes and with modulation of the risk of various pathologies, such as cardiovascular disease and stroke. We analyzed 2 independent cohorts of IS patients. Global DNA methylation was measured by luminometric methylation assay (LUMA) of DNA blood samples. Univariate and multivariate regression analyses were used to assess the methylation differences between the 3 most common IS subtypes, large-artery atherosclerosis (LAA), small-artery disease (SAD), and cardio-aortic embolism (CE). A total of 485 IS patients from 2 independent hospital cohorts (n = 281 and n = 204) were included, distributed across 3 IS subtypes: LAA (78/281, 59/204), SAD (97/281, 53/204), and CE (106/281, 89/204). In univariate analyses, no statistical differences in LUMA levels were observed between the 3 etiologies in either cohort. Multivariate analysis, adjusted by age, sex, hyperlipidemia, and smoking habit, confirmed the lack of differences in methylation levels between the analyzed IS subtypes in both cohorts. Despite differences in pathogenesis, our results showed no global methylation differences between LAA, SAD, and CE subtypes of IS. Further work is required to establish whether the epigenetic mechanism of methylation might play a role in this complex disease. [ABSTRACT FROM AUTHOR]

Published
2014
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44. DNA Isolation Method Is a Source of Global DNA Methylation Variability Measured with LUMA. Experimental Analysis and a Systematic Review.

Author

Soriano-Tárraga, Carolina, Jiménez-Conde, Jordi, Giralt-Steinhauer, Eva, Ois, Ángel, Rodríguez-Campello, Ana, Cuadrado-Godia, Elisa, Fernández-Cadenas, Israel, Montaner, Joan, Lucas, Gavin, Elosua, Roberto, and Roquer, Jaume

Subjects
DNA methylation, BIOLOGY experiments, SYSTEMATIC reviews, GENE expression, BIOTECHNOLOGY research, EPIGENETICS, NUCLEIC acids, MOLECULAR biology
Abstract

In DNA methylation, methyl groups are covalently bound to CpG dinucleotides. However, the assumption that methyl groups are not lost during routine DNA extraction has not been empirically tested. To avoid nonbiological associations in DNA methylation studies, it is essential to account for potential batch effect bias in the assessment of this epigenetic mechanism. Our purpose was to determine if the DNA isolation method is an independent source of variability in methylation status. We quantified Global DNA Methylation (GDM) by luminometric methylation assay (LUMA), comparing the results from 3 different DNA isolation methods. In the controlled analysis (n = 9), GDM differed slightly for the same individual depending on extraction method. In the population analysis (n = 580) there were significant differences in GDM between the 3 DNA isolation methods (medians, 78.1%, 76.5% and 75.1%; p<0.001). A systematic review of published data from LUMA GDM studies that specify DNA extraction methods is concordant with our findings. DNA isolation method is a source of GDM variability measured with LUMA. To avoid possible bias, the method used should be reported and taken into account in future DNA methylation studies. [ABSTRACT FROM AUTHOR]

Published
2013
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45. Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study

Author

Pulit, Sara L., McArdle, Patrick F., Wong, Quenna, Malik, Rainer, Gwinn, Katrina, Achterberg, Sefanja, Algra, Ale, Amouyel, Philippe, Anderson, Christopher D., Arnett, Donna K., Arsava, Ethem Murat, Attia, John, Ay, Hakan, Bartz, Traci M., Battey, Thomas, Benavente, Oscar R., Bevan, Steve, Biffi, Alessandro, Bis, Joshua C., Blanton, Susan H., Boncoraglio, Giorgio B., Brown, Robert D., Burgess, Annette I., Carrera, Caty, Chapman Smith, Sherita N., Chasman, Daniel I., Chauhan, Ganesh, Chen, Wei-Min, Cheng, Yu-Ching, Chong, Michael, Cloonan, Lisa K., Cole, John W., Cotlarciuc, Ioana, Cruchaga, Carlos, Cuadrado-Godia, Elisa, Dave, Tushar, Dawson, Jesse, Debette, Stéphanie, Delavaran, Hossein, Dell, Cameron A., Dichgans, Martin, Doheny, Kimberly F., Dong, Chuanhui, Duggan, David J., Engström, Gunnar, Evans, Michele K., Pallejà, Xavier Estivill, Faul, Jessica D., Fernández-Cadenas, Israel, Fornage, Myriam, Frossard, Philippe M., Furie, Karen, Gamble, Dale M., Gieger, Christian, Giese, Anne-Katrin, Giralt-Steinhauer, Eva, González, Hector M., Goris, An, Gretarsdottir, Solveig, Grewal, Raji P., Grittner, Ulrike, Gustafsson, Stefan, Han, Buhm, Hankey, Graeme J., Heitsch, Laura, Higgins, Peter, Hochberg, Marc C., Holliday, Elizabeth, Hopewell, Jemma C., Horenstein, Richard B., Howard, George, Ikram, M. Arfan, Ilinca, Andreea, Ingelsson, Erik, Irvin, Marguerite R., Jackson, Rebecca D., Jern, Christina, Conde, Jordi Jiménez, Johnson, Julie A., Jood, Katarina, Kahn, Muhammad S., Kaplan, Robert, Kappelle, L Jaap, Kardia, Sharon L. R., Keene, Keith L., Kissela, Brett M., Kleindorfer, Dawn O., Koblar, Simon, Labovitz, Daniel, Launer, Lenore J., Laurie, Cathy C., Laurie, Cecelia A., Lee, Cue Hyunkyu, Lee, Jin-Moo, Lehm, Manuel, Lemmens, Robin, Levi, Christopher, Leys, Didier, Lindgren, Arne, Longstreth, W. T., Maguire, Jane, Manichaikul, Ani, Markus, Hugh S., McClure, Leslie A., McDonough, Caitrin W., Meisinger, Christa, Melander, Olle, Meschia, James F., Mola-Caminal, Marina, Montaner, Joan, Mosley, Thomas H., Müller-Nurasyid, Martina, Nalls, Mike A., O'Connell, Jeffrey R., O'Donnell, Martin, Ois, ángel, Papanicolaou, George J., Paré, Guillaume, Peddareddygari, Leema Reddy, Pedersén, Annie, Pera, Joanna, Peters, Annette, Poole, Deborah, Psaty, Bruce M., Rabionet, Raquel, Raffeld, Miriam R., Rannikmäe, Kristiina, Rasheed, Asif, Redfors, Petra, Reiner, Alex P., Rexrode, Kathryn, Ribasés, Marta, Rich, Stephen S., Robberecht, Wim, Rodriguez-Campello, Ana, Rolfs, Arndt, Roquer, Jaume, Rose, Lynda M., Rosenbaum, Daniel, Rost, Natalia S., Rothwell, Peter M., Rundek, Tatjana, Ryan, Kathleen A., Sacco, Ralph L., Sale, Michèle M., Saleheen, Danish, Salomaa, Veikko, Sánchez-Mora, Cristina, Schmidt, Carsten Oliver, Schmidt, Helena, Schmidt, Reinhold, Schürks, Markus, Scott, Rodney, Segal, Helen C., Seiler, Stephan, Seshadri, Sudha, Sharma, Pankaj, Shuldiner, Alan R., Silver, Brian, Slowik, Agnieszka, Smith, Jennifer A., Söderholm, Martin, Soriano, Carolina, Sparks, Mary J., Stanne, Tara, Stefansson, Kari, Stine, O. Colin, Strauch, Konstantin, Sturm, Jonathan, Sudlow, Cathie L. M., Tajuddin, Salman M., Talbert, Robert L., Tatlisumak, Turgut, Thijs, Vincent, Thorleifsson, Gudmar, Thorsteindottir, Unnur, Tiedt, Steffen, Traylor, Matthew, Trompet, Stella, Valant, Valerie, Waldenberger, Melanie, Walters, Matthew, Wang, Liyong, Wassertheil-Smoller, Sylvia, Weir, David R., Wiggins, Kerri L., Williams, Stephen R., Wloch-Kopec, Dorota, Woo, Daniel, Woodfield, Rebecca, Wu, Ona, Xu, Huichun, Zonderman, Alan B., Worrall, Bradford B., de Bakker, Paul I. W., Kittner, Steven J., Mitchell, Braxton D., Rosand, Jonathan, Worrall, Bradford B. Worrall, Arnett, Donna K. Arnett, Benavente, Oscar, Wasssertheil-Smoller, Sylvia, Pulit, Sara L., McArdle, Patrick F., Wong, Quenna, Malik, Rainer, Gwinn, Katrina, Achterberg, Sefanja, Algra, Ale, Amouyel, Philippe, Anderson, Christopher D., Arnett, Donna K., Arsava, Ethem Murat, Attia, John, Ay, Hakan, Bartz, Traci M., Battey, Thomas, Benavente, Oscar R., Bevan, Steve, Biffi, Alessandro, Bis, Joshua C., Blanton, Susan H., Boncoraglio, Giorgio B., Brown, Robert D., Burgess, Annette I., Carrera, Caty, Chapman Smith, Sherita N., Chasman, Daniel I., Chauhan, Ganesh, Chen, Wei-Min, Cheng, Yu-Ching, Chong, Michael, Cloonan, Lisa K., Cole, John W., Cotlarciuc, Ioana, Cruchaga, Carlos, Cuadrado-Godia, Elisa, Dave, Tushar, Dawson, Jesse, Debette, Stéphanie, Delavaran, Hossein, Dell, Cameron A., Dichgans, Martin, Doheny, Kimberly F., Dong, Chuanhui, Duggan, David J., Engström, Gunnar, Evans, Michele K., Pallejà, Xavier Estivill, Faul, Jessica D., Fernández-Cadenas, Israel, Fornage, Myriam, Frossard, Philippe M., Furie, Karen, Gamble, Dale M., Gieger, Christian, Giese, Anne-Katrin, Giralt-Steinhauer, Eva, González, Hector M., Goris, An, Gretarsdottir, Solveig, Grewal, Raji P., Grittner, Ulrike, Gustafsson, Stefan, Han, Buhm, Hankey, Graeme J., Heitsch, Laura, Higgins, Peter, Hochberg, Marc C., Holliday, Elizabeth, Hopewell, Jemma C., Horenstein, Richard B., Howard, George, Ikram, M. Arfan, Ilinca, Andreea, Ingelsson, Erik, Irvin, Marguerite R., Jackson, Rebecca D., Jern, Christina, Conde, Jordi Jiménez, Johnson, Julie A., Jood, Katarina, Kahn, Muhammad S., Kaplan, Robert, Kappelle, L Jaap, Kardia, Sharon L. R., Keene, Keith L., Kissela, Brett M., Kleindorfer, Dawn O., Koblar, Simon, Labovitz, Daniel, Launer, Lenore J., Laurie, Cathy C., Laurie, Cecelia A., Lee, Cue Hyunkyu, Lee, Jin-Moo, Lehm, Manuel, Lemmens, Robin, Levi, Christopher, Leys, Didier, Lindgren, Arne, Longstreth, W. T., Maguire, Jane, Manichaikul, Ani, Markus, Hugh S., McClure, Leslie A., McDonough, Caitrin W., Meisinger, Christa, Melander, Olle, Meschia, James F., Mola-Caminal, Marina, Montaner, Joan, Mosley, Thomas H., Müller-Nurasyid, Martina, Nalls, Mike A., O'Connell, Jeffrey R., O'Donnell, Martin, Ois, ángel, Papanicolaou, George J., Paré, Guillaume, Peddareddygari, Leema Reddy, Pedersén, Annie, Pera, Joanna, Peters, Annette, Poole, Deborah, Psaty, Bruce M., Rabionet, Raquel, Raffeld, Miriam R., Rannikmäe, Kristiina, Rasheed, Asif, Redfors, Petra, Reiner, Alex P., Rexrode, Kathryn, Ribasés, Marta, Rich, Stephen S., Robberecht, Wim, Rodriguez-Campello, Ana, Rolfs, Arndt, Roquer, Jaume, Rose, Lynda M., Rosenbaum, Daniel, Rost, Natalia S., Rothwell, Peter M., Rundek, Tatjana, Ryan, Kathleen A., Sacco, Ralph L., Sale, Michèle M., Saleheen, Danish, Salomaa, Veikko, Sánchez-Mora, Cristina, Schmidt, Carsten Oliver, Schmidt, Helena, Schmidt, Reinhold, Schürks, Markus, Scott, Rodney, Segal, Helen C., Seiler, Stephan, Seshadri, Sudha, Sharma, Pankaj, Shuldiner, Alan R., Silver, Brian, Slowik, Agnieszka, Smith, Jennifer A., Söderholm, Martin, Soriano, Carolina, Sparks, Mary J., Stanne, Tara, Stefansson, Kari, Stine, O. Colin, Strauch, Konstantin, Sturm, Jonathan, Sudlow, Cathie L. M., Tajuddin, Salman M., Talbert, Robert L., Tatlisumak, Turgut, Thijs, Vincent, Thorleifsson, Gudmar, Thorsteindottir, Unnur, Tiedt, Steffen, Traylor, Matthew, Trompet, Stella, Valant, Valerie, Waldenberger, Melanie, Walters, Matthew, Wang, Liyong, Wassertheil-Smoller, Sylvia, Weir, David R., Wiggins, Kerri L., Williams, Stephen R., Wloch-Kopec, Dorota, Woo, Daniel, Woodfield, Rebecca, Wu, Ona, Xu, Huichun, Zonderman, Alan B., Worrall, Bradford B., de Bakker, Paul I. W., Kittner, Steven J., Mitchell, Braxton D., Rosand, Jonathan, Worrall, Bradford B. Worrall, Arnett, Donna K. Arnett, Benavente, Oscar, and Wasssertheil-Smoller, Sylvia

Abstract

BACKGROUND: The discovery of disease-associated loci through genome-wide association studies (GWAS) is the leading genetic approach to the identification of novel biological pathways underlying diseases in humans. Until recently, GWAS in ischaemic stroke have been limited by small sample sizes and have yielded few loci associated with ischaemic stroke. We did a large-scale GWAS to identify additional susceptibility genes for stroke and its subtypes. METHODS: To identify genetic loci associated with ischaemic stroke, we did a two-stage GWAS. In the first stage, we included 16 851 cases with state-of-the-art phenotyping data and 32 473 stroke-free controls. Cases were aged 16 to 104 years, recruited between 1989 and 2012, and subtypes of ischaemic stroke were recorded by centrally trained and certified investigators who used the web-based protocol, Causative Classification of Stroke (CCS). We constructed case-control strata by identifying samples that were genotyped on nearly identical arrays and were of similar genetic ancestral background. We cleaned and imputed data by use of dense imputation reference panels generated from whole-genome sequence data. We did genome-wide testing to identify stroke-associated loci within each stratum for each available phenotype, and we combined summary-level results using inverse variance-weighted fixed-effects meta-analysis. In the second stage, we did in-silico lookups of 1372 single nucleotide polymorphisms identified from the first stage GWAS in 20 941 cases and 364 736 unique stroke-free controls. The ischaemic stroke subtypes of these cases had previously been established with the Trial of Org 10 172 in Acute Stroke Treatment (TOAST) classification system, in accordance with local standards. Results from the two stages were then jointly analysed in a final meta-analysis. FINDINGS: We identified a novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke (fir

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