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Your search keyword '"Ohtsuru, Shigeru"' showing total 152 results
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152 results on '"Ohtsuru, Shigeru"'

1. Auxiliary roles of nardilysin in the early diagnosis of acute coronary syndrome: a prospective cohort study, the Nardi-ACS study

Author

Ohno, Mikiko, Shiomi, Hiroki, Baba, Osamu, Yano, Mariko, Aizawa, Takanori, Nakano-Matsumura, Yukiko, Yamagami, Shintaro, Kato, Masashi, Ohya, Masanobu, Chen, Po-Min, Nagao, Kazuya, Ando, Kenji, Yokomatsu, Takafumi, Kadota, Kazushige, Kouchi, Ichiro, Inada, Tsukasa, Valentine, Cindy, Kitagawa, Takahiro, Kurokawa, Masato, Ohtsuru, Shigeru, Morimoto, Takeshi, Kimura, Takeshi, and Nishi, Eiichiro

Published
2024
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18. Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2‐mutation carriers

Author

Mori, Tomoharu, primary, Okamoto, Yusuke, additional, Mu, Anfeng, additional, Ide, Yoshimi, additional, Yoshimura, Akiyo, additional, Senda, Noriko, additional, Inagaki‐Kawata, Yukiko, additional, Kawashima, Masahiro, additional, Kitao, Hiroyuki, additional, Tokunaga, Eriko, additional, Miyoshi, Yasuo, additional, Ohsumi, Shozo, additional, Tsugawa, Koichiro, additional, Ohta, Tomohiko, additional, Katagiri, Toyomasa, additional, Ohtsuru, Shigeru, additional, Koike, Kaoru, additional, Ogawa, Seishi, additional, Toi, Masakazu, additional, Iwata, Hiroji, additional, Nakamura, Seigo, additional, Matsuo, Keitaro, additional, and Takata, Minoru, additional

Published
2022
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23. Dexmedetomidine versus haloperidol for sedation of non-intubated patients with hyperactive delirium during the night in a high dependency unit: study protocol for an open-label, parallel-group, randomized controlled trial (DEX-HD trial).

Author

Minami, Takuma, Watanabe, Hirotoshi, Kato, Takao, Ikeda, Kaori, Ueno, Kentaro, Matsuyama, Ai, Maeda, Junya, Sakai, Yoji, Harada, Hisako, Kuriyama, Akira, Yamaji, Kyohei, Kitajima, Naoki, Kamei, Jun, Takatani, Yudai, Sato, Yuki, Yamashita, Yugo, Mizota, Toshiyuki, and Ohtsuru, Shigeru

Subjects
INTENSIVE care units, DRUG efficacy, EXPERIMENTAL design, ANESTHESIA, TIME, TERTIARY care, PATIENTS, INVESTIGATIONAL drugs, IMIDAZOLES, HALOPERIDOL, RANDOMIZED controlled trials, TREATMENT effectiveness, DELIRIUM, EMERGENCY medical services, RESEARCH funding, PATIENT safety, EVALUATION
Abstract

Background: Delirium is common in critically ill patients. Haloperidol has long been used for the treatment of delirium. Dexmedetomidine has recently been used to treat delirium among intubated critically ill patients. However, the efficacy of dexmedetomidine for delirium in non-intubated critically ill patients remains unknown. We hypothesize that dexmedetomidine is superior to haloperidol for sedation of patients with hyperactive delirium, and would reduce the prevalence of delirium among non-intubated patients after administration. We will conduct a randomized controlled trial to compare dexmedetomidine and haloperidol for the treatment of nocturnal hyperactive delirium in non-intubated patients in high dependency units (HDUs). Methods: This is an open-label, parallel-group, randomized controlled trial to compare the efficacy and safety of dexmedetomidine and haloperidol for nocturnal hyperactive delirium in non-intubated patients at two HDUs of a tertiary hospital. We will recruit consecutive non-intubated patients who are admitted to the HDU from the emergency room, and allocate them in a 1:1 ratio to the dexmedetomidine or haloperidol group in advance. The allocated investigational drug will be administered only when participants develop hyperactive delirium (Richmond Agitation-Sedation Scale [RASS] score ≥1 and a positive score on the Confusion Assessment Method for the ICU between 19:00 and 6:00 the next day) during the night at an HDU. Dexmedetomidine is administered continuously, while haloperidol is administered intermittently. The primary outcome is the proportion of participants who achieve the targeted sedation level (RASS score of between -3 and 0) 2h after the administration of the investigational drug. Secondary outcomes include the sedation level and prevalence of delirium on the day following the administration of the investigational drugs, and safety. We plan to enroll 100 participants who develop nocturnal hyperactive delirium and receive one of the two investigational drugs. Discussion: This is the first randomized controlled trial to compare the efficacy and safety of dexmedetomidine and haloperidol for sedation of non-intubated critically ill patients with hyperactive delirium in HDUs. The results of this study may confirm whether dexmedetomidine could be another option to sedate patients with hyperactive delirium. Trial registration: Japan Registry of Clinical Trials, jRCT1051220015, registered on 21 April 2022. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2‐mutation carriers.

Author

Mori, Tomoharu, Okamoto, Yusuke, Mu, Anfeng, Ide, Yoshimi, Yoshimura, Akiyo, Senda, Noriko, Inagaki‐Kawata, Yukiko, Kawashima, Masahiro, Kitao, Hiroyuki, Tokunaga, Eriko, Miyoshi, Yasuo, Ohsumi, Shozo, Tsugawa, Koichiro, Ohta, Tomohiko, Katagiri, Toyomasa, Ohtsuru, Shigeru, Koike, Kaoru, Ogawa, Seishi, Toi, Masakazu, and Iwata, Hiroji

Subjects
CARCINOGENESIS, BREAST cancer, FANCONI'S anemia, ARTIFICIAL chromosomes, OVARIAN cancer
Abstract

The aldehyde degrading function of the ALDH2 enzyme is impaired by Glu504Lys polymorphisms (rs671, termed A allele), which causes alcohol flushing in east Asians, and elevates the risk of esophageal cancer among habitual drinkers. Recent studies suggested that the ALDH2 variant may lead to higher levels of DNA damage caused by endogenously generated aldehydes. This can be a threat to genome stability and/or cell viability in a synthetic manner in DNA repair‐defective settings such as Fanconi anemia (FA). FA is an inherited bone marrow failure syndrome caused by defects in any one of so far identified 22 FANC genes including hereditary breast and ovarian cancer (HBOC) genes BRCA1 and BRCA2. We have previously reported that the progression of FA phenotypes is accelerated with the ALDH2 rs671 genotype. Individuals with HBOC are heterozygously mutated in either BRCA1 or BRCA2, and the cancer‐initiating cells in these patients usually undergo loss of the wild‐type BRCA1/2 allele, leading to homologous recombination defects. Therefore, we hypothesized that the ALDH2 genotypes may impact breast cancer development in BRCA1/2 mutant carriers. We genotyped ALDH2 in 103 HBOC patients recruited from multiple cancer centers in Japan. However, we were not able to detect any significant differences in clinical stages, histopathological classification, or age at clinical diagnosis across the ALDH2 genotypes. Unlike the effects in hematopoietic cells of FA, our current data suggest that there is no impact of the loss of ALDH2 function in cancer initiation and development in breast epithelium of HBOC patients. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Clinical Phenotyping of Out-of-Hospital Cardiac Arrest Patients With Shockable Rhythm ― Machine Learning-Based Unsupervised Cluster Analysis ―

Author

Okada, Yohei, primary, Komukai, Sho, additional, Kitamura, Tetsuhisa, additional, Kiguchi, Takeyuki, additional, Irisawa, Taro, additional, Yamada, Tomoki, additional, Yoshiya, Kazuhisa, additional, Park, Changhwi, additional, Nishimura, Tetsuro, additional, Ishibe, Takuya, additional, Yagi, Yoshiki, additional, Kishimoto, Masafumi, additional, Inoue, Toshiya, additional, Hayashi, Yasuyuki, additional, Sogabe, Taku, additional, Morooka, Takaya, additional, Sakamoto, Haruko, additional, Suzuki, Keitaro, additional, Nakamura, Fumiko, additional, Matsuyama, Tasuku, additional, Nishioka, Norihiro, additional, Kobayashi, Daisuke, additional, Matsui, Satoshi, additional, Hirayama, Atsushi, additional, Yoshimura, Satoshi, additional, Kimata, Shunsuke, additional, Shimazu, Takeshi, additional, Ohtsuru, Shigeru, additional, and Iwami, Taku, additional

Published
2022
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31. Successful treatment of COVID-19-related acute respiratory distress syndrome with rare blood type: A case report

Author

Yamada, Hiroyuki, primary, Ohtsuru, Shigeru, additional, Nagatomo, Mika, additional, Korogi, Yohei, additional, Shinozuka, Ken, additional, Tanabe, Naoya, additional, Kai, Shinichi, additional, Matsubara, Takeshi, additional, Ito, Isao, additional, Ihara, Masahiro, additional, Tanaka, Tomoharu, additional, Kato, Genta, additional, Nagao, Miki, additional, and Date, Hiroshi, additional

Published
2021
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33. Population pharmacokinetic modeling of GS‐441524, the active metabolite of remdesivir, in Japanese COVID‐19 patients with renal dysfunction

Author

Sukeishi, Asami, primary, Itohara, Kotaro, additional, Yonezawa, Atsushi, additional, Sato, Yuki, additional, Matsumura, Katsuyuki, additional, Katada, Yoshiki, additional, Nakagawa, Takayuki, additional, Hamada, Satoshi, additional, Tanabe, Naoya, additional, Imoto, Eishi, additional, Kai, Shinichi, additional, Hirai, Toyohiro, additional, Yanagita, Motoko, additional, Ohtsuru, Shigeru, additional, Terada, Tomohiro, additional, and Ito, Isao, additional

Published
2021
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37. Successful treatment of COVID‐19‐related acute respiratory distress syndrome with a rare blood type: A case report

Author

Yamada, Hiroyuki, primary, Ohtsuru, Shigeru, additional, Nagatomo, Mika, additional, Korogi, Yohei, additional, Shinozuka, Ken, additional, Tanabe, Naoya, additional, Kai, Shinichi, additional, Matsubara, Takeshi, additional, Ito, Isao, additional, Ihara, Masahiro, additional, Tanaka, Tomoharu, additional, Kato, Genta, additional, Nagao, Miki, additional, and Date, Hiroshi, additional

Published
2021
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39. Additional file 1 of Machine learning-based prediction models for accidental hypothermia patients

Author

Okada, Yohei, Matsuyama, Tasuku, Morita, Sachiko, Ehara, Naoki, Miyamae, Nobuhiro, Jo, Takaaki, Sumida, Yasuyuki, Nobunaga Okada, Watanabe, Makoto, Nozawa, Masahiro, Tsuruoka, Ayumu, Fujimoto, Yoshihiro, Okumura, Yoshiki, Tetsuhisa Kitamura, Iiduka, Ryoji, and Ohtsuru, Shigeru

Abstract

Additional file 1: Supplementary Appendix 1. Explanation of J-point registry. Supplementary Appendix 2. Explanation of 5A score. Supplementary Appendix 3. Net-benefit and decision curve analysis. Supplementary Figure 1. Mortality by SOFA score. Supplementary Table 1. Missing value. Supplementary Table 2. Predictors described by outcome. Supplementary Table 3. Hyperparameters in machine learning models. Supplementary Table 4. Difference of C-statistics in each model

Published
2021
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40. Additional file 1 of Diagnostic accuracy of physical examination for detecting pelvic fractures among blunt trauma patients: a systematic review and meta-analysis

Author

Okada, Yohei, Nishioka, Norihiro, Ohtsuru, Shigeru, and Tsujimoto, Yasushi

Abstract

Additional file 1. S-Table 1. Excluded literatures by full-text screening. S-Table 2. The detail of the assessment of QUDAS-2 tool. S-Figure 1. The quality of the included studies in the sub-group of level of consciousness. S-Figure 2. The results of sensitivity analysis excluding the studies using index test other than pre-defined in the protocol. S-Figure 3. The results of sensitivity analysis excluding the studies using reference standard as only x-ray or unclear. S-Figure 4. The results of post-hoc sensitivity analysis only excluding the studies evaluated as “High risk of bias”.

Published
2020
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41. 314: Peritoneal Dialysis for COVID-19-Related Acute Kidney Injury: A Case Report

Author

Nagatomo, Mika, primary, Yamada, Hiroyuki, additional, Shinozuka, Ken, additional, Tokuyama, Yuuki, additional, Matsumoto, Noriaki, additional, Kawai, Takao, additional, Nakamura, Shunsuke, additional, Tarumoto, Koji, additional, Kakuda, Youhei, additional, Minami, Takuma, additional, Inoue, Kyo, additional, Tsutsumi, Takahiko, additional, Takatani, Yudai, additional, Okuno, Yoshinori, additional, Jingami, Naoto, additional, Furutake, Tatsuya, additional, Shimoto, Manabu, additional, Cho, Kosai, additional, Yunoki, Tomoyuki, additional, and Ohtsuru, Shigeru, additional

Published
2020
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42. Development and Validation of a Clinical Score to Predict Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation

Author

Okada, Yohei, primary, Kiguchi, Takeyuki, additional, Irisawa, Taro, additional, Yamada, Tomoki, additional, Yoshiya, Kazuhisa, additional, Park, Changhwi, additional, Nishimura, Tetsuro, additional, Ishibe, Takuya, additional, Yagi, Yoshiki, additional, Kishimoto, Masafumi, additional, Inoue, Toshiya, additional, Hayashi, Yasuyuki, additional, Sogabe, Taku, additional, Morooka, Takaya, additional, Sakamoto, Haruko, additional, Suzuki, Keitaro, additional, Nakamura, Fumiko, additional, Matsuyama, Tasuku, additional, Nishioka, Norihiro, additional, Kobayashi, Daisuke, additional, Matsui, Satoshi, additional, Hirayama, Atsushi, additional, Yoshimura, Satoshi, additional, Kimata, Shunsuke, additional, Shimazu, Takeshi, additional, Ohtsuru, Shigeru, additional, Kitamura, Tetsuhisa, additional, and Iwami, Taku, additional

Published
2020
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45. Population pharmacokinetic modeling of GS‐441524, the active metabolite of remdesivir, in Japanese COVID‐19 patients with renal dysfunction.

Author

Sukeishi, Asami, Itohara, Kotaro, Yonezawa, Atsushi, Sato, Yuki, Matsumura, Katsuyuki, Katada, Yoshiki, Nakagawa, Takayuki, Hamada, Satoshi, Tanabe, Naoya, Imoto, Eishi, Kai, Shinichi, Hirai, Toyohiro, Yanagita, Motoko, Ohtsuru, Shigeru, Terada, Tomohiro, and Ito, Isao

Subjects
JAPANESE people, COVID-19, CORONAVIRUS disease treatment, KIDNEY diseases, REMDESIVIR, EXTRACORPOREAL membrane oxygenation
Abstract

Remdesivir, a prodrug of the nucleoside analog GS‐441524, plays a key role in the treatment of coronavirus disease 2019 (COVID‐19). However, owing to limited information on clinical trials and inexperienced clinical use, there is a lack of pharmacokinetic (PK) data in patients with COVID‐19 with special characteristics. In this study, we aimed to measure serum GS‐441524 concentrations and develop a population PK (PopPK) model. Remdesivir was administered at a 200 mg loading dose on the first day followed by 100 mg from day 2, based on the package insert, in patients with an estimated glomerular filtration rate (eGFR) greater than or equal to 30 ml/min. In total, 190 concentrations from 37 Japanese patients were used in the analysis. The GS‐441524 trough concentrations were significantly higher in the eGFR less than 60 ml/min group than in the eGFR greater than or equal to 60 ml/min group. Extracorporeal membrane oxygenation in four patients hardly affected the total body clearance (CL) and volume of distribution (Vd) of GS‐441524. A one‐compartment model described serum GS‐441524 concentration data. The CL and Vd of GS‐441524 were significantly affected by eGFR readjusted by individual body surface area and age, respectively. Simulations proposed a dose regimen of 200 mg on day 1 followed by 100 mg once every 2 days from day 2 in patients with an eGFR of 30 ml/min or less. In conclusion, we successfully established a PopPK model of GS‐441524 using retrospectively obtained serum GS‐441524 concentrations in Japanese patients with COVID‐19, which would be helpful for optimal individualized therapy of remdesivir. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Anterior Choroidal Artery Infarction Evaluated with ¹²³I-Imp Single-Photon Emission Computed Tomography and 7 Tesla Magnetic Resonance Imaging

Author

Wang, Te Hsiung, Jingami, Naoto, Okada, Tomohisa, Yunoki, Tomoyuki, Ohtsuru, Shigeru, and Koike, Kaoru

Subjects
Anterior choroidal artery infarction, Monakow's syndrome, 7T-MRA, thalamus, SPECT, cardiovascular system, cardiovascular diseases
Abstract

Anterior choroidal artery (AchA) infarction remains a challenging diagnosis although it was first described almost 100 years prior. N-isopropyl-p-[¹²³I]-iodoamphetamine single-photon emission computed tomography (¹²³I-IMP SPECT) and 7 Tesla magnetic resonance angiography (7T-MRA) are not routinely performed in cases of AchA infarction. Therefore, the application of ¹²³I-IMP SPECT and 7T-MRA for AchA infarction has not been reported previously. A 67-year-old man presented with disturbed consciousness, gaze preference to the left, aphasia, right homonymous hemianopia, and right hemiparesis. Brain magnetic resonance imaging revealed infarction of the left posterior limb of the internal capsule. Left middle cerebral artery was clearly seen on MRA. However, ¹²³I-IMP SPECT on day 13 showed cortical hypoperfusion which indicated thalamus involvement with neural deactivation. Additionally, 7T-MRA on day 15 revealed an intact left AchA suggesting reperfusion. The neurological deficits improved gradually after treatment and rehabilitation. This case demonstrates AchA infarction with cortical hypoperfusion associated with thalamus involvement, which was clarified by performing ¹²³I-IMP SPECT and 7T-MRA. Perfusion analysis and evaluation of detailed vascular anatomy in stroke can be expected to elucidate pathological conditions.

Published
2019

48. Convulsive seizure and pulmonary edema during hyperbaric oxygen therapy : A case report

Author

Cho, Kosai, Minami, Takeya, Okuno, Yoshinori, Kakuda, Youhei, Tsutsumi, Takahiko, Kogame, Toshiaki, Ohtsuru, Shigeru, Sato, Norio, Koike, Kaoru, Cho, Kosai, Minami, Takeya, Okuno, Yoshinori, Kakuda, Youhei, Tsutsumi, Takahiko, Kogame, Toshiaki, Ohtsuru, Shigeru, Sato, Norio, and Koike, Kaoru

Abstract

Hyperbaric oxygen therapy (HBOT) for carbon monoxide (CO) poisoning is widely performed to prevent delayed neuropsychiatric syndrome. Although HBOT can generally be performed with safety, the appropriate management of HBOT still remains unestablished. A 31-year-old man was transferred to our facility to undergo HBOT in a multiplace chamber with a diagnosis of CO poisoning. The first HBOT session ended uneventfully. During the second HBOT session, the patient suddenly experienced convulsive seizures. The accompanying doctor administered intravenous propofol to stop the convulsion and terminated the HBOT. Soon after the convulsion, the patient developed frothy secretions through the endotracheal-tube with impaired oxygenation. Head computed tomography scan showed no abnormalities, suggesting the seizure was associated with complications of HBOT. A chest X-ray revealed bilateral pulmonary edema, and echocardiography revealed normal cardiac function, indicating that the pulmonary edema resulted from HBOT or neurogenic mechanism secondary to the seizure. The patient’s respiratory status improved without recurrence of the seizure and no delayed neurological sequelae was seen afterwards. Here we report unexpected rare adverse events during HBOT. Hyperbaric oxygen therapy for acute indications should be performed in multiplace chambers, with appropriate preparation and medical equipment.

Published
2018

49. What's Going On?

Author

Kawai, Toshiki, primary, Chino, Hiroki, additional, Matsumura, Kohei, additional, Noma, Haruo, additional, Sugiyama, Osamu, additional, Shimoto, Manabu, additional, Ohtsuru, Shigeru, additional, and Kuroda, Tomohiro, additional

Published
2018
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