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460 results on '"Ohtsuki, Hiroshi"'

9. Twist Knot: A New Sliding Noose in Adjustable Suture Strabismus Surgery

Author

Shibata, Kiyo, Hamasaki, Ichiro, Shimizu, Takehiro, Kono, Reika, Ohtsuki, Hiroshi, Morizane, Yuki, and Shiraga, Fumio

Subjects
tensile strength, esotropia, strabismus surgery, adjustable suture, the new sliding noose method
Abstract

To permit noose movement without fraying the sutures following strabismus surgery, we designed a new sliding noose, the “twist knot” and investigated its advantages and disadvantages. We measured the tensile strength required to move the twist knot in a tightly tied state (134±19 gf) and in a loosened state (21±7 gf), and that required to move the conventional sliding noose in a tightly tied state (48±14 gf), and used the Kruskal-Wallis test to compare them. A significant difference was observed among the three tensile strengths (p

Published
2019

22. Age-related change and sex difference over 60s in disc-fovea angle in Japanese population: the Nagahama Study

Author

Miyata, Manabu, Yoshikawa, Munemitsu, Ohtsuki, Hiroshi, Muraoka, Yuki, Hata, Masayuki, Yokota, Satoshi, Fujimoto, Masahiro, Miyake, Masahiro, Tabara, Yasuharu, Matsuda, Fumihiko, Yoshimura, Nagahisa, and Nagahama Study Group

Subjects
objective ocular torsion, genetic structures, stomatognathic system, Nagahama Study, sex difference, menopause, sense organs, urologic and male genital diseases, disc-fovea angle, age-related change, eye diseases
Abstract

Purpose: To analyse the disc-fovea angle (DFA) by age group and to compare sex differences in each age group in a large cohort population. Methods: This community-based cross-sectional cohort study included 9682 eyes of 9682 volunteers (aged 30–75 years). We measured the DFA, which is the angle between a horizontal line and a line connecting the fovea with the centroid of an optic disc on fundus photographs of the right eye. We manually marked the fovea and surrounded the optic disc. The centroid of an optic disc and the DFA was automatically calculated using originally developed software. We compared the DFA between age groups in 10-year increments and investigated sex differences of DFA in each age group. Results: Overall mean DFA was 6.32 ± 3.53°. The DFA of older subjects was significantly larger than that of younger subjects (p < 0.001). The DFA of women was larger than that of men in their 60s and 70s (p < 0.001 for both), but not in subjects in their 30s, 40s and 50s. Conclusion: Larger DFA in women than in men in their 60s and 70s suggests the possibility that age-related excyclo-shift occurs more easily in postmenopausal women compared to men of the same age.

Published
2018

27. Iris movement mediates vascular apoptosis during rat pupillary membrane regression

Author

Morizane, Yuki, Mohri, Satoshi, Kosaka, Jun, Tone, Shigenobu, Kiyooka, Takahiko, Miyasaka, Takehiro, Shimizu, Juichiro, Ogasawara, Yasuo, Shiraga, Fumio, Minatogawa, Yohsuke, Sasaki, Junzo, Ohtsuki, Hiroshi, and Kajiya, Fumihiko

Subjects
Rats -- Health aspects, Rattus -- Health aspects, Apoptosis -- Research, Microcirculation -- Research, Biological sciences
Abstract

In the course of mammalian lens development, a transient capillary meshwork known as the pupillary membrane (PM) forms, which is located at the pupil area; the PM nourishes the anterior surface of the lens and then regresses to make the optical path clear. Although the involvement of apoptotic process has been reported in the PM regression, the initiating factor remains unknown. We initially found that regression of the PM coincided with the development of iris motility, and iris movement caused cessation and resumption of blood flow within the PM. Therefore, we investigated whether the development of the iris's ability to constrict and dilate functions as an essential signal that induces apoptosis in the PM. Continuous inhibition of iris movement with mydriatic agents from postnatal day 7 to day 12 suppressed apoptosis of the PM and migration of macrophage toward the PM, and resulted in the persistence of PM in rats. The distribution of apoptotic cells in the regressing PM was diffuse and showed no apparent localization. These results indicated that iris movement induced regression of the PM by changing the blood flow within it. This study suggests the importance of the physiological interactions between tissues--in this case, the iris and the PM--as a signal to advance vascular regression during organ development, and defines a novel function of the iris during ocular development in addition to the well-known function, that is, optimization of light transmission into the eye. ocular development; miosis; mydriasis; microcirculation

Published
2006

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