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710 results on '"Ohshima, Hayato"'

16. Mast4 determines the cell fate of MSCs for bone and cartilage development

Author

Kim, Pyunggang, Park, Jinah, Lee, Dong-Joon, Mizuno, Seiya, Shinohara, Masahiro, Hong, Chang Pyo, Jeong, Yealeen, Yun, Rebecca, Park, Hyeyeon, Park, Sujin, Yang, Kyung-Min, Lee, Min-Jung, Jang, Seung Pil, Kim, Hyun-Yi, Lee, Seung-Jun, Song, Sun U., Park, Kyung-Soon, Tanaka, Mikako, Ohshima, Hayato, Cho, Jin Won, Sugiyama, Fumihiro, Takahashi, Satoru, Jung, Han-Sung, and Kim, Seong-Jin

Published
2022
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21. Effects of Synthetic Toll-Like Receptor 9 Ligand Molecules on Pulpal Immunomodulatory Response and Repair after Injuries.

Author

Quispe-Salcedo, Angela, Yamazaki, Tomohiko, and Ohshima, Hayato

Subjects
DENTAL pulp, SYNTHETIC receptors, BIOMARKERS, DENTAL pulp cavities, TOLL-like receptors
Abstract

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated cytosine–phosphate–guanine (CpG) motifs (CpG-ODNs) are ligand molecules for Toll-like receptor 9 (TLR9), which is expressed by odontoblasts in vitro and dental pulp cells. This study determined the effects of CpG-ODNs on pulpal immunomodulatory response and repair following injury. Briefly, the upper right first molars of three-week-old mice were extracted, immersed in Type A (D35) or B (K3) CpG-ODN solutions (0.1 or 0.8 mM) for 30 min, and then replanted. Pulpal healing and immunomodulatory activity were assessed by hematoxylin–eosin and AZAN staining, as well as immunohistochemistry. One week following the operation, inflammatory reactions occurred in all of the experimental groups; however, re-revascularization and newly formed hard tissue deposition were observed in the pulp chamber of all groups at week 2. A positive trend in the expression of immune cell markers was observed toward the CpG-ODN groups at 0.1 mM. Our data suggest that synthetic CpG-ODN solutions at low concentrations may evoke a long-lasting macrophage–TLR9-mediated pro-inflammatory, rather than anti-inflammatory, response in the dental pulp to modulate the repair process and hard tissue formation. Further studies are needed to determine the effects of current immunomodulatory agents in vitro and in vivo and develop treatment strategies for dental tissue regeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Trends in the multiple prescriptions of hypnotic drugs in a university outpatient in Japan.

Author

Kato, Takao, Kotorii, Nozomu, Ozone, Motohiro, Murotani, Kenta, Ohshima, Hayato, Mori, Hiroyuki, Wasano, Kenjirou, Hiejima, Hiroshi, Habukawa, Mitsunari, and Uchimura, Naohisa

Subjects
HYPNOTICS, DRUGS, DRUG prescribing, PSYCHIATRIC drugs, PSYCHIATRIC clinics
Abstract

Aims: In Japan, the daily dosage of hypnotic drugs for insomnia treatment is increasing year by year, and over‐dependence on treatment with hypnotic drugs is a major problem. This study aimed to examine the factors related to the elimination of prescriptions of three or more hypnotic drugs within 1 year in our clinic. Methods: We conducted two surveys. Survey ① assessed the frequency of prescriptions of three or more hypnotic drugs by retrospectively reviewing the medical records of all patients who visited general and psychiatric outpatient clinics from January 2013 to March 2019. Survey ② assessed changes in prescriptions of hypnotic and psychotropic drugs within the subsequent year by retrospectively reviewing the medical records of all patients prescribed three or more hypnotic drugs who visited neuropsychiatric outpatient clinics multiple times between April 2013 and March 2019. Results: The frequency of prescribing three or more hypnotic drugs was six to nine times higher in psychiatry than in other departments. Flunitrazepam and brotizolam were the most common drugs prescribed and had the second lowest discontinuation rate after zolpidem. Conversely, eszopiclone, zopiclone, and suvorexant had the highest discontinuation rates. The success factors for drug reduction were age (odds ratio [OR]: 0.97, p < 0.0037), trazodone addition (OR: 12.86, p < 0.0194) and number of years of psychiatric experience. Conclusions: The characteristics and success factors in relation to drug reduction in patients with multiple prescriptions of hypnotic drugs identified in this study may contribute to solving the problem of multiple prescriptions of hypnotic drugs. [ABSTRACT FROM AUTHOR]

Published
2024
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