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461 results on '"Ohlsson, Rolf"'

2. BORIS, A Novel Male Germ-Line-Specific Protein Associated with Epigenetic Reprogramming Events, Shares the Same 11-Zinc-Finger Domain with CTCF, The Insulator Protein Involved in Reading Imprinting Marks in the Soma

Author

Loukinov, Dmitri I., Pugacheva, Elena, Vatolin, Sergei, Pack, Svetlana D., Moon, Hanlim, Chernukhin, Igor, Mannan, Poonam, Larsson, Erik, Kanduri, Chandrasekhar, Vostrov, Alexander A., Cui, Hengmi, Niemitz, Emily L., Docquier, France M., Kistler, Malathi, Breen, Joseph J., Zhuang, Zhengping, Quitschke, Wolfgang W., Renkawitz, Rainer, Klenova, Elena M., Feinberg, Andrew P., Ohlsson, Rolf, Morse, Herbert C., and Lobanenkov, Victor V.

Published
2002

7. MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells

Author

Sumida, Noriyuki, Sifakis, Emmanouil G, Kiani, Narsis A, Ronnegren, Anna Lewandowska, Scholz, Barbara A, Vestlund, Johanna, Gomez-Cabrero, David, Tegner, Jesper, Göndör, Anita, and Ohlsson, Rolf

Subjects
Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, Stochastic Processes, Narese/3, AcademicSubjects/SCI00010, Carcinogenesis, Gene regulation, Chromatin and Epigenetics, Animals, Humans, Drosophila, Gene Regulatory Networks, Chromatin Assembly and Disassembly, HCT116 Cells
Abstract

The relationship between stochastic transcriptional bursts and dynamic 3D chromatin states is not well understood. Using an innovated, ultra-sensitive technique, we address here enigmatic features underlying the communications between MYC and its enhancers in relation to the transcriptional process. MYC thus interacts with its flanking enhancers in a mutually exclusive manner documenting that enhancer hubs impinging on MYC detected in large cell populations likely do not exist in single cells. Dynamic encounters with pathologically activated enhancers responsive to a range of environmental cues, involved

Published
2020

21. Chromosome crosstalk in three dimensions

Author

Gondor, Anita and Ohlsson, Rolf

Subjects
Chromatin -- Observations -- Genetic aspects, Drosophila -- Genetic aspects, Chromosomes -- Structure -- Observations -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation, Structure, Observations, Genetic aspects
Abstract

The genome forms extensive and dynamic physical interactions with itself in the form of chromosome loops and bridges, thus exploring the three-dimensional space of the nucleus. It is now possible to examine these interactions at the molecular level, and we have gained glimpses of their functional implications. Chromosomal interactions can contribute to the silencing and activation of genes within the three-dimensional context of the nuclear architecture. Technical advances in detecting these interactions contribute to our understanding of the functional organization of the genome, as well as its adaptive plasticity in response to environmental changes during development and disease., The complexity of chromosome architecture has been known about since the end of the nineteenth century, when chromatin loops were first visualized (1). Subsequently, the early Drosophila geneticists perceived the [...]

Published
2009

36. The Expansion of the Education Sector in Sweden During the 20th Century.

Author

National Swedish Board of Universities and Colleges, Stockholm. Research and Development Unit. and Ohlsson, Rolf

Abstract

Three investigations on quantitative changes in higher education in Sweden are described. In Anders Nilsson's dissertation, "Study Financing and Social Recruitment to Higher Education (1920-1976)," attention was focused on changes in college recruitment from 1920 until reforms in 1977; the effect of various college financing conditions on recruitment; and enrollment trends. Variations in enrollment of different social groups were considered, as measured by enrollment ratio from upper-secondary school (gymnasium) to higher education (universities). Lars Pettersson's dissertation, "Engineering Education and Capital Formation (1933-1973)," provides an historical explanation for the expansion in engineering education in Sweden against the background of the growth and transformation of the economy. Consideration was given to changes in the labor market for engineers that affected salaries and, thereby, the demand for engineering education. Rulf Ohlsson's study, "Higher Education and Demographic Change," analyzed the short- and long-term changes in the annual flow to higher education during 1923-1975. Enrollment ratios were constructed for different student groups (e.g., male students, female students, engineering students, foreign students). The variations in the flow to college were assessed using a human capital model. (SW)

Published
1985

37. The Labor Market and Structural Changes in the Economy: Higher Education as a Sorting Device?

Author

National Swedish Board of Universities and Colleges, Stockholm. Research and Development Unit., Ohlsson, Rolf, and Nilsson, Anders

Abstract

The Swedish employment structure and the role of colleges in preparing people for work is being studied by the Swedish Research on Higher Education program. The project is designed to: survey changes in the Swedish economy and employment structure during the postwar period; assess the extent to which business and industry have given priority to the cognitive function of education, as opposed to the function of creating and transmitting information about the student; and to examine the extent to which higher education has adapted to changes in the employment structure. Topics of concern include: mobility in the labor market, wages at the recruiting stage as well as after the first years of employment, changes in the hierarchy of employees, and unemployment statistics. Attempts by the Swedish government to steer higher education in the direction of vocational training are also assessed. The study is based on the assumption that colleges generate and collect information about the students' abilities, which is transmitted to the student and to employers. Education develops students' skills and therefore increases the individual's productivity. Different theories/models of the role of colleges are discussed, including the human-capital theory, sorting models, and filtering/screening models. (SW)

Published
1984

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