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5. Pharmacogenetics in Psychiatry

Author

Tsapakis, Evangelia M., primary, Curran, Sarah, additional, Ohlsen, Ruth I., additional, Vyas, Nora S., additional, Aitchison, Katherine J., additional, and Daly, Ann K., additional

Published
2012
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11. Associations between the LEP -2548G/A Promoter and Baseline Weight and between LEPR Gln223Arg and Lys656Asn Variants and Change in BMI z Scores in Arab Children and Adolescents Treated with Risperidone

Author

Almandil, Noor B., primary, Lodhi, Rohit J., additional, Ren, Hongyan, additional, Besag, Frank M.C., additional, Rossolatos, David, additional, Ohlsen, Ruth, additional, Slomp, Caitlin, additional, Lapetina, Diego L., additional, Plazzotta, Giona, additional, Murray, Macey L., additional, Al-Sulaiman, Abdulsalam A., additional, Gringras, Paul, additional, Wong, Ian C.K., additional, and Aitchison, Katherine J., additional

Published
2018
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13. Randomised controlled trial to improve health and reduce substance use in established psychosis (IMPaCT): cost-effectiveness of integrated psychosocial health promotion

Author

Heslin, Margaret, primary, Patel, Anita, additional, Stahl, Daniel, additional, Gardner-Sood, Poonam, additional, Mushore, Manyara, additional, Smith, Shubulade, additional, Greenwood, Kathryn, additional, Onagbesan, Oluwadamilola, additional, O’Brien, Conan, additional, Fung, Catherine, additional, Ohlsen, Ruth, additional, Hopkins, David, additional, Lowe, Philippa, additional, Arbuthnot, Maurice, additional, Mutatsa, Stan, additional, Todd, Gill, additional, Kolliakou, Anna, additional, Lally, John, additional, Stubbs, Brendon, additional, Ismail, Khalida, additional, David, Anthony, additional, Murray, Robin, additional, Atakan, Zerrin, additional, and Gaughran, Fiona, additional

Published
2017
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15. Influences on uptake of cancer screening in mental health service users: a qualitative study

Author

Clifton, Abigail, Burgess, Caroline, Clement, Sarah, Ohlsen, Ruth, Ramluggun, Pras, Sturt, Jackie, Walters, Paul, Barley, Elizabeth, Clifton, Abigail, Burgess, Caroline, Clement, Sarah, Ohlsen, Ruth, Ramluggun, Pras, Sturt, Jackie, Walters, Paul, and Barley, Elizabeth

Abstract

Background Cancers are a leading cause of death worldwide. People with mental illness are 30 % more likely to die from cancer than the general population. One reason for this may be low uptake of nationally offered cancer screening tests by people with mental illness. We aimed to identify barriers and facilitators for breast, cervical and bowel cancer screening uptake by people with mental illness in order to inform interventions to promote equal access. Methods The interview study was conducted in both urban and rural settings. The study was informed by the Theoretical Domains Framework, using framework analysis and triangulation across participant groups. Participants included 45 mental health service users (service users) eligible for cancer screening, 29 mental health professionals and 11 professionals involved in cancer screening. Results Themes emerging from the data that affected uptake included knowledge of screening programmes by both service users and healthcare providers; knowledge of, and attitudes towards, mental illness; health service-delivery factors; service users’ beliefs and concerns about cancer screening, and practical issues. These are relevant to different stages of the screening process. Service users do not receive invitations to screening or cancer testing kits if they are admitted to hospital. They are not routinely invited for screening if they are not registered with a general practitioner (GP). Lack of integrated care means that mental health staff do not know if someone is overdue for a test and cancer screening is often not considered during health promotion. Barriers including information processing problems, the extent to which the screening process aggravates symptoms, poor staff client relationships and travel difficulties vary between individuals. Screening professionals are motivated to help, but may lack time or training to manage mental health needs. Reactive measures are available, but service users must request help which th

Published
2016

17. A qualitative study exploring the experience of people with IBD and elevated symptoms of anxiety and low mood and the type of psychological help they would like.

Author

Jordan, Cheryl, Ohlsen, Ruth, Hayee, Bu’Hussain, and Chalder, Trudie

Subjects
*AFFECTIVE disorders, *MENTAL health services, *ANXIETY treatment, *CLINICAL competence, *COGNITION, *INFLAMMATORY bowel diseases, *INTERVIEWING, *PSYCHOTHERAPISTS, *SOCIAL stigma, *QUALITATIVE research, *SOCIAL support, *TREATMENT effectiveness, *SYMPTOMS, *PSYCHOLOGY
Abstract

Background: People with inflammatory bowel disease (IBD) are at increased risk of developing anxiety and low mood. We sought to explore the experience of people with IBD and moderate-severe symptoms of anxiety/low mood to identify psychological processes which could be targeted in psychological interventions, as well as the kind of psychological support preferred. Methods: Twenty-five participants with IBD and moderate-severe symptoms of anxiety/low mood were recruited for interview. Template analysis was utilised to analyse interview data. We explored the situations, cognitions and behaviour linked to symptoms of anxiety and low mood by people with IBD, as well as the kind of psychological help preferred. Results: Two themes were identified within participants accounts of symptoms of anxiety; ‘under performance’ and ‘preventing an accident’. Two further themes were identified for symptoms of low mood; ‘lack of understanding’ and ‘stigma’. Expertise and understanding was the main theme identified for the type of psychological help desired. Conclusion: The analysis highlights situations, cognitions and behaviour linked to anxiety and low mood by people with IBD and the type of psychological support desired. Our findings link to the knowledge and competencies set for psychological therapist working with long-term conditions. [ABSTRACT FROM AUTHOR]

Published
2018
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19. Associations between the LEP-2548G/A Promoter and Baseline Weight and between LEPRGln223Arg and Lys656Asn Variants and Change in BMI zScores in Arab Children and Adolescents Treated with Risperidone

Author

Almandil, Noor B., Lodhi, Rohit J., Ren, Hongyan, Besag, Frank M.C., Rossolatos, David, Ohlsen, Ruth, Slomp, Caitlin, Lapetina, Diego L., Plazzotta, Giona, Murray, Macey L., Al-Sulaiman, Abdulsalam A., Gringras, Paul, Wong, Ian C.K., and Aitchison, Katherine J.

Abstract

Data on baseline (antipsychotics-naïve) age, weight, and height, and change in these at 3 subsequent follow-up time points up to 313.6 days (95% CI 303.5–323.7) were collected from 181 risperidone-treated children and adolescents (mean age 12.58 years, SD 4.99, range 2.17–17.7) attending a pediatric neurology clinic in Saudi Arabia. Owing to differences in genotypic distributions in the subsamples, results are reported for the white Arab population (n= 144). Age- and gender-normed body mass index (BMI)-standardized zscores (BMI z) were calculated (LMSgrowth program). Linear regression was performed for baseline weight and BMI z, while change in BMI zwas assessed using random effects ordered logistic regression. The following single nucleotide polymorphisms (SNPs) were analyzed: rs7799039 in the LEPpromoter, rs1805094 (previously rs8179183), rs1137100 and rs1137101 in the LEPR, and rs1414334 in HTR2C. We found a nominally significant association between rs7799309 and baseline weight, adjusting for height, age, gender, and diagnosis (A/G, p= 0.035, β= –3.62 vs. G/G). The rs1137101 (G/G, p= 0.018, odds ratio [OR] = 4.13 vs. A/A) and rs1805094 C allele carriers (p= 0.019, OR = 0.51) showed nominally significant associations with change in BMI zcategories. Our data support and replicate previous relevant associations for these variants (including with weight gain when on risperidone), whilst being the first report of such associations in patients of Arab ethnicity.

Published
2018
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24. To the editor

Author

Ohlsen, Ruth, primary, Treasure, Janet, additional, and Pilowsky, Lyn, additional

Published
2004
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26. Additional file 2: Tables S1 to S3. of Influences on uptake of cancer screening in mental health service users: a qualitative study

Author

Clifton, Abigail, Burgess, Caroline, Clement, Sarah, Ohlsen, Ruth, Pras Ramluggun, Sturt, Jackie, Walters, Paul, and Barley, Elizabeth

Subjects
education, health care economics and organizations, humanities, 3. Good health
Abstract

Barriers and Facilitators by participant and screening type. Themes, barriers and facilitators identified in the sample of people living with a diagnosis of mental illness, in the sample of screening professionals and in the sample of mental health professionals. (DOCX 19Â kb)

28. Randomised control trial of the effectiveness of an integrated psychosocial health promotion intervention aimed at improving health and reducing substance use in established psychosis (IMPaCT)

Author

Gaughran, Fiona, Stahl, Daniel, Ismail, Khalida, Greenwood, Kathryn, Atakan, Zerrin, Gardner-Sood, Poonam, Stubbs, Brendon, Hopkins, David, Patel, Anita, Lally, John, Lowe, Philippa, Arbuthnot, Maurice, Orr, Diana, Corlett, Sarah, Eberhard, Jonas, David, Anthony S., Murray, Robin, Smith, Shubulade, Harries, Bee, Moore, Susan, Bonaccorso, Stefania, Kolliakou, Anna, O Brien, Conan, Featherman, Ali, Fung, Catherine, Heslin, Margaret, Dalemo, Keji, Anakwe-Umeh, Stella, Todd, Gill, Mushore, Manyara, Mutsatsa, Stanley, Howes, Oliver, Ohlsen, Ruth, Papanastasiou, Evangelos, Muhammad Firdosi, Sallis, Hannah, Sambath, Irene, Di Clemente, Guilia, Breedvelt, Josefine, Joseph, Candice, Di Forti, Marta, Odesanya, Adewale, Onagbesan, Dami, Case, Philippa, Musa, Augustine, Dalton, Christine, Antionades, Hannah, Reece, Ben, Healy, Andy, Sinan, Funda, Rudhra, Keerthana, Kelly, Hannah, Treasure, Janet, Davis, Anthony, Murphy, Caroline, Kelly, Joanna, Goldin, Matthew, and on behalf of the IMPaCT Team

29. Additional file 1: of Influences on uptake of cancer screening in mental health service users: a qualitative study

Author

Clifton, Abigail, Burgess, Caroline, Clement, Sarah, Ohlsen, Ruth, Pras Ramluggun, Sturt, Jackie, Walters, Paul, and Barley, Elizabeth

Subjects
education, health care economics and organizations, humanities, 3. Good health
Abstract

Interview Schedules. Interview schedules for people living with a diagnosis of mental illness, for screening professionals and for mental health professionals. (DOCX 33Â kb)

30. Additional file 1: of Influences on uptake of cancer screening in mental health service users: a qualitative study

Author

Clifton, Abigail, Burgess, Caroline, Clement, Sarah, Ohlsen, Ruth, Pras Ramluggun, Sturt, Jackie, Walters, Paul, and Barley, Elizabeth

Subjects
education, health care economics and organizations, humanities, 3. Good health
Abstract

Interview Schedules. Interview schedules for people living with a diagnosis of mental illness, for screening professionals and for mental health professionals. (DOCX 33Â kb)

31. Additional file 2: Tables S1 to S3. of Influences on uptake of cancer screening in mental health service users: a qualitative study

Author

Clifton, Abigail, Burgess, Caroline, Clement, Sarah, Ohlsen, Ruth, Pras Ramluggun, Sturt, Jackie, Walters, Paul, and Barley, Elizabeth

Subjects
education, health care economics and organizations, humanities, 3. Good health
Abstract

Barriers and Facilitators by participant and screening type. Themes, barriers and facilitators identified in the sample of people living with a diagnosis of mental illness, in the sample of screening professionals and in the sample of mental health professionals. (DOCX 19Â kb)

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