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5. Design and Construction of the DEAP-3600 Dark Matter Detector

Author

Amaudruz, P. -A., Baldwin, M., Batygov, M., Beltran, B., Bina, C. E., Bishop, D., Bonatt, J., Boorman, G., Boulay, M. G., Broerman, B., Bromwich, T., Bueno, J. F., Burghardt, P. M., Butcher, A., Cai, B., Chan, S., Chen, M., Chouinard, R., Churchwell, S., Cleveland, B. T., Cranshaw, D., Dering, K., DiGioseffo, J., Dittmeier, S., Duncan, F. A., Dunford, M., Erlandson, A., Fatemighomi, N., Florian, S., Flower, A., Ford, R. J., Gagnon, R., Giampa, P., Golovko, V. V., Gorel, P., Gornea, R., Grace, E., Graham, K., Grant, D. R., Gulyev, E., Hall, A., Hallin, A. L., Hamstra, M., Harvey, P. J., Hearns, C., Jillings, C. J., Kamaev, O., Kemp, A., Kuźniak, M., Langrock, S., La Zia, F., Lehnert, B., Li, O., Lidgard, J. J., Liimatainen, P., Lim, C., Lindner, T., Linn, Y., Liu, S., Majewski, P., Mathew, R., McDonald, A. B., McElroy, T., McFarlane, K., McGinn, T., McLaughlin, J. B., Mead, S., Mehdiyev, R., Mielnichuk, C., Monroe, J., Muir, A., Nadeau, P., Nantais, C., Ng, C., Noble, A. J., O'Dwyer, E., Ohlmann, C., Olchanski, K., Olsen, K. S., Ouellet, C., Pasuthip, P., Peeters, S. J. M., Pollmann, T. R., Rand, E. T., Rau, W., Rethmeier, C., Retière, F., Seeburn, N., Shaw, B., Singhrao, K., Skensved, P., Smith, B., Smith, N. J. T., Sonley, T., Soukup, J., Stainforth, R., Stone, C., Strickland, V., Sur, B., Tang, J., Taylor, J., Veloce, L., Vázquez-Jáuregui, E., Walding, J., Ward, M., Westerdale, S., White, R., Woolsey, E., and Zielinski, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The Dark matter Experiment using Argon Pulse-shape discrimination (DEAP) has been designed for a direct detection search for particle dark matter using a single-phase liquid argon target. The projected cross section sensitivity for DEAP-3600 to the spin-independent scattering of Weakly Interacting Massive Particles (WIMPs) on nucleons is $10^{-46}~\rm{cm}^{2}$ for a 100 GeV/$c^2$ WIMP mass with a fiducial exposure of 3 tonne-years. This paper describes the physical properties and construction of the DEAP-3600 detector., Comment: minor corrections in version 2. 70 pages, 24 figures, to be submitted to Astroparticle Physics Journal

Published
2017
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6. In-situ characterization of the Hamamatsu R5912-HQE photomultiplier tubes used in the DEAP-3600 experiment

Author

Amaudruz, P-A, Batygov, M, Beltran, B, Bina, CE, Bishop, D, Bonatt, J, Boorman, G, Boulay, MG, Broerman, B, Bromwich, T, Bueno, JF, Butcher, A, Cai, B, Chan, S, Chen, M, Chouinard, R, Churchwell, S, Cleveland, BT, Cranshaw, D, Dering, K, Dittmeier, S, Duncan, FA, Dunford, M, Erlandson, A, Fatemighomi, N, Ford, RJ, Gagnon, R, Giampa, P, Golovko, VV, Gorel, P, Gornea, R, Grace, E, Graham, K, Grant, DR, Gulyev, E, Hall, A, Hallin, AL, Hamstra, M, Harvey, PJ, Hearns, C, Jillings, CJ, Kamaev, O, Kemp, A, Kuźniak, M, Langrock, S, La Zia, F, Lehnert, B, Li, O, Lidgard, JJ, Liimatainen, P, Lim, C, Lindner, T, Linn, Y, Liu, S, Mathew, R, McDonald, AB, McElroy, T, McFarlane, K, McLaughlin, J, Mead, S, Mehdiyev, R, Mielnichuk, C, Monroe, J, Muir, A, Nadeau, P, Nantais, C, Ng, C, Noble, AJ, O’Dwyer, E, Ohlmann, C, Olchanski, K, Olsen, KS, Ouellet, C, Pasuthip, P, Peeters, SJM, Pollmann, TR, Rand, ET, Rau, W, Rethmeier, C, Retière, F, Seeburn, N, Shaw, B, Singhrao, K, Skensved, P, Smith, B, Smith, NJT, Sonley, T, Stainforth, R, Stone, C, Strickland, V, Sur, B, Tang, J, Taylor, J, Veloce, L, Vázquez-Jáuregui, E, Walding, J, Ward, M, Westerdale, S, White, R, and Woolsey, E

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, PMT, Hamamatsu R5912-HQE, Single photoelectron charge distribution, Afterpulsing, Late and double pulsing, Dark noise, Dark matter detection, physics.ins-det, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences, Nuclear & Particles Physics, Nuclear and plasma physics
Abstract

The Hamamatsu R5912-HQE photomultiplier-tube (PMT) is a novel high-quantum efficiency PMT. It is currently used in the DEAP-3600 dark matter detector and is of significant interest for future dark matter and neutrino experiments where high signal yields are needed. We report on the methods developed for in-situ characterization and monitoring of DEAP's 255 R5912-HQE PMTs. This includes a detailed discussion of typical measured single-photoelectron charge distributions, correlated noise (afterpulsing), dark noise, double, and late pulsing characteristics. The characterization is performed during the detector commissioning phase using laser light injected through a light diffusing sphere and during normal detector operation using LED light injected through optical fibres.

Published
2019

7. In-situ characterization of the Hamamatsu R5912-HQE photomultiplier tubes used in the DEAP-3600 experiment

Author

Amaudruz, PA, Batygov, M, Beltran, B, Bina, CE, Bishop, D, Bonatt, J, Boorman, G, Boulay, MG, Broerman, B, Bromwich, T, Bueno, JF, Butcher, A, Cai, B, Chan, S, Chen, M, Chouinard, R, Churchwell, S, Cleveland, BT, Cranshaw, D, Dering, K, Dittmeier, S, Duncan, FA, Dunford, M, Erlandson, A, Fatemighomi, N, Ford, RJ, Gagnon, R, Giampa, P, Golovko, VV, Gorel, P, Gornea, R, Grace, E, Graham, K, Grant, DR, Gulyev, E, Hall, A, Hallin, AL, Hamstra, M, Harvey, PJ, Hearns, C, Jillings, CJ, Kamaev, O, Kemp, A, Kuźniak, M, Langrock, S, La Zia, F, Lehnert, B, Li, O, Lidgard, JJ, Liimatainen, P, Lim, C, Lindner, T, Linn, Y, Liu, S, Mathew, R, McDonald, AB, McElroy, T, McFarlane, K, McLaughlin, J, Mead, S, Mehdiyev, R, Mielnichuk, C, Monroe, J, Muir, A, Nadeau, P, Nantais, C, Ng, C, Noble, AJ, O'Dwyer, E, Ohlmann, C, Olchanski, K, Olsen, KS, Ouellet, C, Pasuthip, P, Peeters, SJM, Pollmann, TR, Rand, ET, Rau, W, Rethmeier, C, Retière, F, Seeburn, N, Shaw, B, Singhrao, K, Skensved, P, Smith, B, Smith, NJT, Sonley, T, Stainforth, R, Stone, C, Strickland, V, Sur, B, Tang, J, Taylor, J, Veloce, L, Vázquez-Jáuregui, E, Walding, J, Ward, M, Westerdale, S, White, R, and Woolsey, E

Subjects
PMT, Hamamatsu R5912-HQE, Single photoelectron charge distribution, Afterpulsing, Late and double pulsing, Dark noise, Dark matter detection, physics.ins-det, Nuclear & Particles Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences
Abstract

The Hamamatsu R5912-HQE photomultiplier-tube (PMT) is a novel high-quantum efficiency PMT. It is currently used in the DEAP-3600 dark matter detector and is of significant interest for future dark matter and neutrino experiments where high signal yields are needed. We report on the methods developed for in-situ characterization and monitoring of DEAP's 255 R5912-HQE PMTs. This includes a detailed discussion of typical measured single-photoelectron charge distributions, correlated noise (afterpulsing), dark noise, double, and late pulsing characteristics. The characterization is performed during the detector commissioning phase using laser light injected through a light diffusing sphere and during normal detector operation using LED light injected through optical fibres.

Published
2019

8. Design and construction of the DEAP-3600 dark matter detector

Author

Amaudruz, P-A, Baldwin, M, Batygov, M, Beltran, B, Bina, CE, Bishop, D, Bonatt, J, Boorman, G, Boulay, MG, Broerman, B, Bromwich, T, Bueno, JF, Burghardt, PM, Butcher, A, Cai, B, Chan, S, Chen, M, Chouinard, R, Churchwell, S, Cleveland, BT, Cranshaw, D, Dering, K, DiGioseffo, J, Dittmeier, S, Duncan, FA, Dunford, M, Erlandson, A, Fatemighomi, N, Florian, S, Flower, A, Ford, RJ, Gagnon, R, Giampa, P, Golovko, VV, Gorel, P, Gornea, R, Grace, E, Graham, K, Grant, DR, Gulyev, E, Hall, A, Hallin, AL, Hamstra, M, Harvey, PJ, Hearns, C, Jillings, CJ, Kamaev, O, Kemp, A, Kuźniak, M, Langrock, S, La Zia, F, Lehnert, B, Li, O, Lidgard, JJ, Liimatainen, P, Lim, C, Lindner, T, Linn, Y, Liu, S, Majewski, P, Mathew, R, McDonald, AB, McElroy, T, McFarlane, K, McGinn, T, McLaughlin, JB, Mead, S, Mehdiyev, R, Mielnichuk, C, Monroe, J, Muir, A, Nadeau, P, Nantais, C, Ng, C, Noble, AJ, O’Dwyer, E, Ohlmann, C, Olchanski, K, Olsen, KS, Ouellet, C, Pasuthip, P, Peeters, SJM, Pollmann, TR, Rand, ET, Rau, W, Rethmeier, C, Retière, F, Seeburn, N, Shaw, B, Singhrao, K, Skensved, P, Smith, B, Smith, NJT, Sonley, T, Soukup, J, Stainforth, R, Stone, C, Strickland, V, Sur, B, and Tang, J

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Dark matter, WIMP, Liquid Argon, DEAP, SNOLAB, Low background, astro-ph.IM, hep-ex, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics, Astronomical sciences, Particle and high energy physics
Abstract

The Dark matter Experiment using Argon Pulse-shape discrimination (DEAP) has been designed for a direct detection search for particle dark matter using a single-phase liquid argon target. The projected cross section sensitivity for DEAP-3600 to the spin-independent scattering of Weakly Interacting Massive Particles (WIMPs) on nucleons is 10−46cm2 for a 100 GeV/c2 WIMP mass with a fiducial exposure of 3 tonne-years. This paper describes the physical properties and construction of the DEAP-3600 detector.

Published
2019

9. Design and construction of the DEAP-3600 dark matter detector

Author

Amaudruz, PA, Baldwin, M, Batygov, M, Beltran, B, Bina, CE, Bishop, D, Bonatt, J, Boorman, G, Boulay, MG, Broerman, B, Bromwich, T, Bueno, JF, Burghardt, PM, Butcher, A, Cai, B, Chan, S, Chen, M, Chouinard, R, Churchwell, S, Cleveland, BT, Cranshaw, D, Dering, K, DiGioseffo, J, Dittmeier, S, Duncan, FA, Dunford, M, Erlandson, A, Fatemighomi, N, Florian, S, Flower, A, Ford, RJ, Gagnon, R, Giampa, P, Golovko, VV, Gorel, P, Gornea, R, Grace, E, Graham, K, Grant, DR, Gulyev, E, Hall, A, Hallin, AL, Hamstra, M, Harvey, PJ, Hearns, C, Jillings, CJ, Kamaev, O, Kemp, A, Kuźniak, M, Langrock, S, La Zia, F, Lehnert, B, Li, O, Lidgard, JJ, Liimatainen, P, Lim, C, Lindner, T, Linn, Y, Liu, S, Majewski, P, Mathew, R, McDonald, AB, McElroy, T, McFarlane, K, McGinn, T, McLaughlin, JB, Mead, S, Mehdiyev, R, Mielnichuk, C, Monroe, J, Muir, A, Nadeau, P, Nantais, C, Ng, C, Noble, AJ, O'Dwyer, E, Ohlmann, C, Olchanski, K, Olsen, KS, Ouellet, C, Pasuthip, P, Peeters, SJM, Pollmann, TR, Rand, ET, Rau, W, Rethmeier, C, Retière, F, Seeburn, N, Shaw, B, Singhrao, K, Skensved, P, Smith, B, Smith, NJT, Sonley, T, Soukup, J, Stainforth, R, Stone, C, Strickland, V, Sur, B, and Tang, J

Subjects
Dark matter, WIMP, Liquid Argon, DEAP, SNOLAB, Low background, astro-ph.IM, hep-ex, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics
Abstract

The Dark matter Experiment using Argon Pulse-shape discrimination (DEAP) has been designed for a direct detection search for particle dark matter using a single-phase liquid argon target. The projected cross section sensitivity for DEAP-3600 to the spin-independent scattering of Weakly Interacting Massive Particles (WIMPs) on nucleons is 10−46cm2 for a 100 GeV/c2 WIMP mass with a fiducial exposure of 3 tonne-years. This paper describes the physical properties and construction of the DEAP-3600 detector.

Published
2019

11. Kombinationstherapie beim nicht muskelinvasiven Hochrisiko-Blasenkarzinom (HR-NMIBC) mit und ohne BCG-Vorbehandlung: Randomisierte, verumkontrollierte klinische Prüfung der Phase III zur Evaluierung der Wirksamkeit und der Sicherheit von Pembrolizumab (MK-3475) in Kombination mit Bacillus Calmette-Guérin (BCG) bei Patienten mit nicht muskelinvasivem Hochrisiko-Harnblasenkarzinom (HR-NMIBC), das nach einer Induktionstherapie mit BCG persistiert oder rezidiviert, und für BCG-naive Patienten (KEYNOTE-676)

Author

Rexer, H., Ohlmann, C.-H., and Grimm, M.-O.

Published
2022
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12. First results from the DEAP-3600 dark matter search with argon at SNOLAB

Author

Collaboration, DEAP-3600, Amaudruz, P. -A., Baldwin, M., Batygov, M., Beltran, B., Bina, C. E., Bishop, D., Bonatt, J., Boorman, G., Boulay, M. G., Broerman, B., Bromwich, T., Bueno, J. F., Burghardt, P. M., Butcher, A., Cai, B., Chan, S., Chen, M., Chouinard, R., Cleveland, B. T., Cranshaw, D., Dering, K., DiGioseffo, J., Dittmeier, S., Duncan, F. A., Dunford, M., Erlandson, A., Fatemighomi, N., Florian, S., Flower, A., Ford, R. J., Gagnon, R., Giampa, P., Golovko, V. V., Gorel, P., Gornea, R., Grace, E., Graham, K., Gulyev, E., Hakobyan, R., Hall, A., Hallin, A. L., Hamstra, M., Harvey, P. J., Hearns, C., Jillings, C. J., Kamaev, O., Kemp, A., Kuźniak, M., Langrock, S., La Zia, F., Lehnert, B., Lidgard, J. J., Lim, C., Lindner, T., Linn, Y., Liu, S., Majewski, P., Mathew, R., McDonald, A. B., McElroy, T., McGinn, T., McLaughlin, J. B., Mead, S., Mehdiyev, R., Mielnichuk, C., Monroe, J., Muir, A., Nadeau, P., Nantais, C., Ng, C., Noble, A. J., O'Dwyer, E., Ohlmann, C., Olchanski, K., Olsen, K. S., Ouellet, C., Pasuthip, P., Peeters, S. J. M., Pollmann, T. R., Rand, E. T., Rau, W., Rethmeier, C., Retière, F., Seeburn, N., Shaw, B., Singhrao, K., Skensved, P., Smith, B., Smith, N. J. T., Sonley, T., Soukup, J., Stainforth, R., Stone, C., Strickland, V., Sur, B., Tang, J., Taylor, J., Veloce, L., Vázquez-Jáuregui, E., Walding, J., Ward, M., Westerdale, S., Woolsey, E., and Zielinski, J.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

This paper reports the first results of a direct dark matter search with the DEAP-3600 single-phase liquid argon (LAr) detector. The experiment was performed 2 km underground at SNOLAB (Sudbury, Canada) utilizing a large target mass, with the LAr target contained in a spherical acrylic vessel of 3600 kg capacity. The LAr is viewed by an array of PMTs, which would register scintillation light produced by rare nuclear recoil signals induced by dark matter particle scattering. An analysis of 4.44 live days (fiducial exposure of 9.87 tonne-days) of data taken with the nearly full detector during the initial filling phase demonstrates the detector performance and the best electronic recoil rejection using pulse-shape discrimination in argon, with leakage $<1.2\times 10^{-7}$ (90% C.L.) between 16 and 33 keV$_{ee}$. No candidate signal events are observed, which results in the leading limit on WIMP-nucleon spin-independent cross section on argon, $<1.2\times 10^{-44}$ cm$^2$ for a 100 GeV/c$^2$ WIMP mass (90% C.L.)., Comment: Accepted for publication in Physical Review Letters

Published
2017
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13. In-situ characterization of the Hamamatsu R5912-HQE photomultiplier tubes used in the DEAP-3600 experiment

Author

DEAP Collaboration, Amaudruz, P. -A., Batygov, M., Beltran, B., Bina, C. E., Bishop, D., Bonatt, J., Boorman, G., Boulay, M. G., Broerman, B., Bromwich, T., Bueno, J. F., Butcher, A., Cai, B., Chan, S., Chen, M., Chouinard, R., Churchwell, S., Cleveland, B. T., Cranshaw, D., Dering, K., Dittmeier, S., Duncan, F. A., Dunford, M., Erlandson, A., Fatemighomi, N., Ford, R. J., Gagnon, R., Giampa, P., Golovko, V. V., Gorel, P., Gornea, R., Grace, E., Graham, K., Grant, D. R., Gulyev, E., Hall, A., Hallin, A. L., Hamstra, M., Harvey, P. J., Hearns, C., Jillings, C. J., Kamaev, O., Kemp, A., Kuźniak, M., Langrock, S., La Zia, F., Lehnert, B., Li, O., Lidgard, J. J., Liimatainen, P., Lim, C., Lindner, T., Linn, Y., Liu, S., Mathew, R., McDonald, A. B., McElroy, T., McFarlane, K., McLaughlin, J., Mead, S., Mehdiyev, R., Mielnichuk, C., Monroe, J., Muir, A., Nadeau, P., Nantais, C., Ng, C., Noble, A. J., O'Dwyer, E., Ohlmann, C., Olchanski, K., Olsen, K. S., Ouellet, C., Pasuthip, P., Peeters, S. J. M., Pollmann, T. R., Rand, E. T., Rau, W., Rethmeier, C., Retiére, F., Seeburn, N., Shaw, B., Singhrao, K., Skensved, P., Smith, B., Smith, N. J. T., Sonley, T., Stainforth, R., Stone, C., Strickland, V., Sur, B., Tang, J., Taylor, J., Veloce, L., Vázquez-Jáuregui, E., Walding, J., Ward, M., Westerdale, S., White, R., Woolsey, E., and Zielinski, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

The Hamamatsu R5912-HQE photomultiplier-tube (PMT) is a novel high-quantum efficiency PMT. It is currently used in the DEAP-3600 dark matter detector and is of significant interest for future dark matter and neutrino experiments where high signal yields are needed. We report on the methods developed for in-situ characterization and monitoring of DEAP's 255 R5912-HQE PMTs. This includes a detailed discussion of typical measured single-photoelectron charge distributions, correlated noise (afterpulsing), dark noise, double, and late pulsing characteristics. The characterization is performed during the detector commissioning phase using laser light injected through a light diffusing sphere and during normal detector operation using LED light injected through optical fibres.

Published
2017
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18. Design and construction of the DEAP-3600 dark matter detector

Author

Amaudruz, P.-A., Baldwin, M., Batygov, M., Beltran, B., Bina, C.E., Bishop, D., Bonatt, J., Boorman, G., Boulay, M.G., Broerman, B., Bromwich, T., Bueno, J.F., Burghardt, P.M., Butcher, A., Cai, B., Chan, S., Chen, M., Chouinard, R., Churchwell, S., Cleveland, B.T., Cranshaw, D., Dering, K., DiGioseffo, J., Dittmeier, S., Duncan, F.A., Dunford, M., Erlandson, A., Fatemighomi, N., Florian, S., Flower, A., Ford, R.J., Gagnon, R., Giampa, P., Golovko, V.V., Gorel, P., Gornea, R., Grace, E., Graham, K., Grant, D.R., Gulyev, E., Hall, A., Hallin, A.L., Hamstra, M., Harvey, P.J., Hearns, C., Jillings, C.J., Kamaev, O., Kemp, A., Kuźniak, M., Langrock, S., La Zia, F., Lehnert, B., Li, O., Lidgard, J.J., Liimatainen, P., Lim, C., Lindner, T., Linn, Y., Liu, S., Majewski, P., Mathew, R., McDonald, A.B., McElroy, T., McFarlane, K., McGinn, T., McLaughlin, J.B., Mead, S., Mehdiyev, R., Mielnichuk, C., Monroe, J., Muir, A., Nadeau, P., Nantais, C., Ng, C., Noble, A.J., O’Dwyer, E., Ohlmann, C., Olchanski, K., Olsen, K.S., Ouellet, C., Pasuthip, P., Peeters, S.J.M., Pollmann, T.R., Rand, E.T., Rau, W., Rethmeier, C., Retière, F., Seeburn, N., Shaw, B., Singhrao, K., Skensved, P., Smith, B., Smith, N.J.T., Sonley, T., Soukup, J., Stainforth, R., Stone, C., Strickland, V., Sur, B., Tang, J., Taylor, J., Veloce, L., Vázquez-Jáuregui, E., Walding, J., Ward, M., Westerdale, S., White, R., Woolsey, E., and Zielinski, J.

Published
2019
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19. The T2K Experiment

Author

T2K Collaboration, Abe, K., Abgrall, N., Aihara, H., Ajima, Y., Albert, J. B., Allan, D., Amaudruz, P. -A., Andreopoulos, C., Andrieu, B., Anerella, M. D., Angelsen, C., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., de André, J. P. A. M., Autiero, D., Badertscher, A., Ballester, O., Barbi, M., Barker, G. J., Baron, P., Barr, G., Bartoszek, L., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B. E., Berns, H., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Birney, P., Bishop, D., Blackmore, E., Blaszczyk, F. d. M., Blocki, J., Blondel, A., Bodek, A., Bojechko, C., Bouchez, J., Boussuge, T., Boyd, S. B., Boyer, M., Braam, N., Bradford, R., Bravar, A., Briggs, K., Brinson, J. D., Bronner, C., Brook-Roberge, D. G., Bryant, M., Buchanan, N., Budd, H., Cadabeschi, M., Calland, R. G., Calvet, D., Rodríguez, J. Caravaca, Carroll, J., Cartwright, S. L., Carver, A., Castillo, R., Catanesi, M. G., Cavata, C., Cazes, A., Cervera, A., Charrier, J. P., Chavez, C., Choi, S., Chollet, S., Christodoulou, G., Colas, P., Coleman, J., Coleman, W., Collazuol, G., Connolly, K., Cooke, P., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G. S., Davis, S., Day, M., De La Broise, X., de Perio, P., De Rosa, G., Dealtry, T., Debraine, A., Delagnes, E., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Tran, P. Dinh, Dobson, J., Doornbos, J., Dore, U., Drapier, O., Druillole, F., Dufour, F., Dumarchez, J., Durkin, T., Dytman, S., Dziewiecki, M., Dziomba, M., Ellison, B., Emery, S., Ereditato, A., Escallier, J. E., Escudero, L., Esposito, L. S., Faszer, W., Fechner, M., Ferrero, A., Finch, A., Fisher, C., Fitton, M., Flight, R., Forbush, D., Frank, E., Fransham, K., Fujii, Y., Fukuda, Y., Gallop, M., Galymov, V., Ganetis, G. L., Gannaway, F. C., Gaudin, A., Gaweda, J., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Giomataris, I., Giraud, J., Ghosh, A. K., Golan, T., Goldhaber, M., Gomez-Cadenas, J. J., Gomi, S., Gonin, M., Goyette, M., Grant, A., Grant, N., Grañena, F., Greenwood, S., Gumplinger, P., Guzowski, P., Haigh, M. D., Hamano, K., Hansen, C., Hara, T., Harrison, P. F., Hartfiel, B., Hartz, M., Haruyama, T., Hasanen, R., Hasegawa, T., Hastings, N. C., Hastings, S., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Haycock, T. D. J., Hearty, C., Helmer, R. L., Henderson, R., Herlant, S., Higashi, N., Hignight, J., Hiraide, K., Hirose, E., Holeczek, J., Honkanen, N., Horikawa, S., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S. J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Joo, K. K., Jover-Manas, G., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kasey, V., Kato, I., Kawamuko, H., Kearns, E., Kellet, L., Khabibullin, M., Khaleeq, M., Khan, N., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J. Y., Kim, S. -B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Komorowski, T., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurchaninov, L., Kurimoto, Y., Kurjata, R., Kurosawa, Y., Kutter, T., Lagoda, J., Laihem, K., Langstaff, R., Laveder, M., Lawson, T. B., Le, P. T., Coguie, A. Le, Ross, M. Le, Lee, K. P., Lenckowski, M., Licciardi, C., Lim, I. T., Lindner, T., Litchfield, R. P., Longhin, A., Lopez, G. D., Lu, P., Ludovici, L., Lux, T., Macaire, M., Magaletti, L., Mahn, K., Makida, Y., Malafis, C. J., Malek, M., Manly, S., Marchionni, A., Mark, C., Marino, A. D., Marone, A. J., Marteau, J., Martin, J. F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K. S., McGrew, C., McLachlan, T., Mercer, I., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Minvielle, R. E., Mituka, G., Miura, M., Mizouchi, K., Mols, J. -P., Monfregola, L., Monmarthe, E., Moreau, F., Morgan, B., Moriyama, S., Morris, D., Muir, A., Murakami, A., Muratore, J. F., Murdoch, M., Murphy, S., Myslik, J., Nagashima, G., Nakadaira, T., Nakahata, M., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Nelson, B., Nicholls, T. C., Nishikawa, K., Nishino, H., Nitta, K., Nizery, F., Nowak, J. A., Noy, M., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Ohlmann, C., Olchanski, K., Openshaw, R., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Ozaki, T., Pac, M. 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Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The T2K experiment is a long-baseline neutrino oscillation experiment. Its main goal is to measure the last unknown lepton sector mixing angle {\theta}_{13} by observing {\nu}_e appearance in a {\nu}_{\mu} beam. It also aims to make a precision measurement of the known oscillation parameters, {\Delta}m^{2}_{23} and sin^{2} 2{\theta}_{23}, via {\nu}_{\mu} disappearance studies. Other goals of the experiment include various neutrino cross section measurements and sterile neutrino searches. The experiment uses an intense proton beam generated by the J-PARC accelerator in Tokai, Japan, and is composed of a neutrino beamline, a near detector complex (ND280), and a far detector (Super-Kamiokande) located 295 km away from J-PARC. This paper provides a comprehensive review of the instrumentation aspect of the T2K experiment and a summary of the vital information for each subsystem., Comment: 33 pages, 32 figures, Submitted and accepted by NIM A. Editor: Prof. Chang Kee Jung, Department of Physics and Astronomy, SUNY Stony Brook, chang.jung@sunysb.edu, 631-632-8108 Submit Edited to remove line numbers

Published
2011
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20. Is achieving undetectable PSA (uPSA) a prognostic factor for improved overall survival (OS) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) receiving intensified treatments?

Author

Puente, J., primary, López Campos, F., additional, Ohlmann, C., additional, Ríos, E., additional, Santoni, M., additional, Diels, J., additional, Cabrieto, J., additional, Egea, M., additional, Quesada, A., additional, Calderón, J.M., additional, and Birtle, A., additional

Published
2023
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23. Folgelinientherapie mit Cabozantinib bei lokal fortgeschrittenem oder metastasiertem Urothelkarzinom nach Immuntherapieversagen: Cabozantinib bei Patienten mit lokal fortgeschrittenem oder metastasiertem Urothelzellkarzinom mit progredientem Verlauf nach Vortherapie mit einer Kombination aus platinbasierter Chemotherapie und PD-1/PD-L1-Inhibitoren oder Monotherapie mit PD-1/PD-L1-Inhibitoren (CabUC-Trial) – AB 66/18 der AUO

Author

Rexer, H., Bartsch, G., and Ohlmann, C.-H.

Published
2021
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28. Harnblasenkarzinom

Author

vom Dorp, F., Eisenhardt, A., Goebell, P.-J., Gschwend, J., Jakse, G., Jäger, T., Jocham, D., Karl, A., Knüchel Clarke, R., Krege, S., Lümmen, G., Ohlmann, C., Olbricht, T., Otto, T., Rettenmeier, A., Rübben, H., Schenck, M., Schmid, K.W., Stief, C., Stöckle, M., Tritschler, S., Zaak, D., and Rübben, Herbert, editor

Published
2014
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29. Molekular getriggerte Therapie des hormonrefraktären Prostatakarzinoms

Author

Ohlmann, C.-H., Markert, E., Gerharz, M., Pfister, D., Dienes, H.-P., Engelmann, U., and Heidenreich, A.

Abstract

Zusammenfassung: Molekular getriggerte Therapien, sog. „targeted therapies“ haben bereits bei einigen Tumorentitäten die konventionelle Chemotherapie ersetzt und stellen auch für das Prostatakarzinom eine interessante Therapieoption dar. Ziel unserer Studie war es, potentiell therapeutisch nutzbare molekulare Marker für eine „targeted therapy“ beim hormonrefraktären Prostatakarzinom zu analysieren und anhand des Markerprofils eine individualisierte Therapie mit einem Antikörper bzw. einem Tyrosinkinaseinhibitor einzuleiten. Tumorgewebe von 51 Patienten mit einem metastasierten Prostatakarzinom aus der Prostata oder aus Metastasen wurde zunächst auf die immunhistochemische Expression von EGFR, PDGFRβ, Her-2/neu, c-kit und VEGF untersucht. Basierend auf dem Ergebnis der Expressionsanalyse wurde ein Kostenübernahmeantrag bei der Krankenkasse gestellt und bei 8/51 Patienten konnte dann eine Kombinationstherapie aus Docetaxel und der entsprechenden „targeted therapy“ eingeleitet werden. Bei 46/51 (90,2%) Patienten fand sich eine positive Expression von mindestens einem der analysierten molekularen Marker. Eine positive Expression fand sich von EGFR bei 61,2%, von PDGFRβ bei 57,1%, Her-2/neu bei 16,3%, c-kit bei 25,0% und VEGF bei 74,5% der Patienten. Von den 8 Patienten, die eine Therapie erhielten, zeigte sich bei 50% der Fälle ein PSA-Abfall von ≥50% und ein mittleres Überleben von 13,5 Monaten bei einem mittleren Follow-up von 23,6 Monaten. Molekulare Targets waren bei 90% der Patienten mit einem hormonrefraktären Prostatakarzinom exprimiert. Das Markerprofil kann die Basis für eine individualisierte „targeted therapy“ in Kombination mit Docetaxel darstellen. Die Ansprechraten und das mittlere Überleben sind ermutigend, aufgrund der kleinen Fallzahl jedoch nicht aussagekräftig. Die Effektivität dieses Therapieansatzes sollte daher im Rahmen von prospektiven klinischen Studien überprüft werden.

Published
2024
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35. Onkologie und Tumoren

Author

Rohde, V., Cziborra, M., Jockenhövel, F., Simon, J., Gschwend, J. E., Heidenreich, A., Ohlmann, C. H., Hakenberg, O. W., Wirth, M. P., Schmelz, H. U., Albers, P., Özgür, E., Schmelz, Hans U., Sparwasser, Christoph, and Weidner, Wolfgang

Published
2006
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49. Prognosefaktoren für das Überleben des metastasierten Nierenzellkarzinoms

Author

Ohlmann, C.-H.

Abstract

Zusammenfassung: Prognosefaktoren für das Überleben von Patienten mit einem metastasierten Nierenzellkarzinom wurden erstmalig 1999 von Motzer R vom „Memorial-Sloan Kettering Cancer Center“ publiziert, die als sog. „Motzer-Kriterien“ bekannt wurden. Anhand der 5 Prognosefaktoren wurde es möglich, die Patienten vor Einleitung einer Immun- bzw. Immunchemotherapie in 3 Prognosegruppen mit spezifischen Überlebensraten einzuteilen. Seither wurden diese 5 Prognosefaktoren mehrfach modifiziert und erweitert. In unterschiedlicher Weise wurden die verschiedenen Prognosescores in aktuelle Therapiestudien mit den sog. „Target-Therapien“ integriert, so dass teilweise eine Zulassungsbeschränkung der Medikamente für bestimmte Prognosegruppen resultierte.

Published
2024
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