212 results on '"Ohkuma K"'
Search Results
2. Modulation of dendritic cell development by immunoglobulin G in control subjects and multiple sclerosis patients
- Author
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Ohkuma, K., Sasaki, T., Kamei, S., Okuda, S., Nakano, H., Hamamoto, T., Fujihara, K., Nakashima, I., Misu, T., and Itoyama, Y.
- Published
- 2007
3. The removal of endotoxins from protein solutions using column packings with aminated poly (γ-methyl L-glutamate) spheres
- Author
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Hirayama, C., Sakata, M., Morimoto, S., Tachibe, H., Ihara, H., Ohkuma, K., and Miyachi, Y.
- Published
- 1995
- Full Text
- View/download PDF
4. Dehydrogenation of ethylbenzene over iron oxide-based catalyst in the presence of carbon dioxide
- Author
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Mimura, N., primary, Takahara, I., additional, Saito, M., additional, Hattori, T., additional, Ohkuma, K., additional, and Ando, M., additional
- Published
- 1998
- Full Text
- View/download PDF
5. VISUALIZATION OF TUMOR VESSELS IN RENAL TUMORS: Comparison between power Doppler ultrasonography and angiography
- Author
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Tamura, Y., Jinzaki, M., Ohkuma, K., Narimatsu, Y., Hashimoto, S., Tanimoto, A., and Hiramatsu, K.
- Published
- 2001
6. A new quadruple therapy for Helicobacter pylori: influence of resistant strains on treatment outcome
- Author
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OKADA, M., NISHIMURA, H., KAWASHIMA, M., OKABE, N., MAEDA, K., SEO, M., OHKUMA, K., and TAKATA, T.
- Published
- 1999
7. Abscisin II, an Abscission-Accelerating Substance from Young Cotton Fruit
- Author
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Ohkuma, K., Lyon, J. L., Addicott, F. T., and Smith, O. E.
- Published
- 1963
8. An evaluation of the contribution of hatchery stocking on population density and biomass: a lesson from masu salmon juveniles within a Japanese river system
- Author
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Sahashi, G., primary, Morita, K., additional, Ohnuki, T., additional, and Ohkuma, K., additional
- Published
- 2015
- Full Text
- View/download PDF
9. Evidence for cytomegalovirus-induced haemophagocytic syndrome in a young patient with AIDS
- Author
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Ohkuma, K., primary, Saraya, T., additional, Sada, M., additional, and Kawai, S., additional
- Published
- 2013
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- View/download PDF
10. Phantom tumour of the lung
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Saraya, T., primary, Ohkuma, K., additional, Hirata, A., additional, and Nakamoto, K., additional
- Published
- 2013
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- View/download PDF
11. Latitudinal variation in egg size and number in anadromous masu salmonOncorhynchus masou
- Author
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Morita, K., primary, Tamate, T., additional, Sugimoto, Y., additional, Tago, Y., additional, Watanabe, T., additional, Konaka, H., additional, Sato, M., additional, Miyauchi, Y., additional, Ohkuma, K., additional, and Nagasawa, T., additional
- Published
- 2009
- Full Text
- View/download PDF
12. High speed generation of image templates by Genetic Algorithm with fitness inference
- Author
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Doki, K., primary, Ohkuma, K., additional, Torii, A., additional, and Ueda, A., additional
- Published
- 2008
- Full Text
- View/download PDF
13. Abscisic Acid: A New Name for Abscisin II (Dormin)
- Author
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Addicott, F. T., Lyon, J. L., Ohkuma, K., Thiessen, W. E., Carns, H. R., Smith, O. E., Cornforth, J. W., Milborrow, B. V., Ryback, G., and Wareing, P. F.
- Published
- 1968
14. SF/sub 6/ reclaimer from SF/sub 6/N/sub 2/ mixtures by gas separation with molecular sieving effect
- Author
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Toyoda, M., primary, Murase, H., additional, Imai, T., additional, Naotsuka, H., additional, Kobayashi, A., additional, Takano, K., additional, and Ohkuma, K., additional
- Published
- 2003
- Full Text
- View/download PDF
15. Template generation for self-position estimation by Genetic Algorithm with indirect fitness inference.
- Author
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Doki, K., Ohkuma, K., Torii, A., and Ueda, A.
- Published
- 2008
- Full Text
- View/download PDF
16. SF6 Reclaimer from SF6/ N2 Mixtures by Gas Separation with Molecular Sieving Effect
- Author
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Toyoda, M., primary, Murase, H., additional, Imai, T., additional, Naotsuka, H., additional, Kobayashi, A., additional, Takano, K., additional, and Ohkuma, K., additional
- Published
- 2002
- Full Text
- View/download PDF
17. Small Solid Renal Lesions
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Jinzaki, M., primary, Ohkuma, K., additional, Tanimoto, A., additional, Mukai, M., additional, Hiramatsu, K., additional, Murai, M., additional, and Hata, J.-I., additional
- Published
- 1999
- Full Text
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18. Small solid renal lesions: usefulness of power Doppler US.
- Author
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Jinzaki, M, primary, Ohkuma, K, additional, Tanimoto, A, additional, Mukai, M, additional, Hiramatsu, K, additional, Murai, M, additional, and Hata, J, additional
- Published
- 1998
- Full Text
- View/download PDF
19. Angiomyolipoma
- Author
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Jinzaki, M., primary, Tanimoto, A., additional, Narimatsu, Y., additional, Ohkuma, K., additional, Kurata, T., additional, Shinmoto, H., additional, Hiramatsu, K., additional, Mukai, M., additional, and Murai, M., additional
- Published
- 1998
- Full Text
- View/download PDF
20. Angiomyolipoma: Imaging Findings in Lesions With Minimal Fat
- Author
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Jinzaki, M., primary, Tanimoto, A., additional, Narimatsu, Y., additional, Ohkuma, K., additional, Kurata, T., additional, Shinmoto, H., additional, Hiramatsu, K., additional, Mukai, M., additional, and Murai, M., additional
- Published
- 1998
- Full Text
- View/download PDF
21. A peptide-based human T cell leukemia virus type I vaccine containing T and B cell epitopes that induces high titers of neutralizing antibodies.
- Author
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Baba, E, primary, Nakamura, M, additional, Ohkuma, K, additional, Kira, J, additional, Tanaka, Y, additional, Nakano, S, additional, and Niho, Y, additional
- Published
- 1995
- Full Text
- View/download PDF
22. Evaluation of liver fibrosis by transient elastography using acoustic radiation force impulse: comparison with Fibroscan(®).
- Author
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Ebinuma H, Saito H, Komuta M, Ojiro K, Wakabayashi K, Usui S, Chu PS, Umeda R, Ishibashi Y, Takayama T, Kikuchi M, Nakamoto N, Yamagishi Y, Kanai T, Ohkuma K, Sakamoto M, Hibi T, Ebinuma, Hirotoshi, Saito, Hidetsugu, and Komuta, Mina
- Abstract
Background: Accurate evaluation of liver fibrosis in patients with chronic liver damage is required to determine the appropriate treatment. Various approaches, including laboratory tests and transient elastography, have been used to evaluate liver fibrosis. Recently, transient elastography with acoustic radiation force impulse (ARFI) has been developed and applied with conventional ultrasonography. The aim of this study was to evaluate the clinical utility of transient elastography with ARFI and to compare the results with this method and those of the Fibroscan(®) procedure.Methods: One hundred and thirty-one patients with liver damage, who underwent liver biopsy at our department, were enrolled prospectively in this study. Elastography with ARFI (applied with ACUSON S2000(®)), and Fibroscan(®) was performed at the same time as liver biopsy. These measurements were compared with histological findings in liver biopsy specimens, and measurement accuracy was evaluated by receiver-operating characteristic analysis.Results: Elastography values with both procedures were significantly correlated with the stages of liver fibrosis and there was little difference in the results obtained using the 2 procedures. The accuracy of differential diagnosis between no fibrosis at F0 and more than F1 stage was insufficient with ARFI, but this procedure was sufficient for diagnosing advanced fibrosis. The accuracy of ARFI was almost equivalent to that of the Fibroscan(®) method. Moreover, both ARFI and Fibroscan(®) values increased in proportion to the severity of hepatic inflammation when fibrosis stage is low, but not in proportion to the severity of steatosis.Conclusions: Transient elastography with ARFI is simple, non-invasive and useful for diagnosing the stage of fibrosis in chronic liver disease. The utility of ARFI was almost equivalent to that of the Fibroscan(®) method. [ABSTRACT FROM AUTHOR]- Published
- 2011
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- View/download PDF
23. Latitudinal variation in egg size and number in anadromous masu salmon Oncorhynchus masou.
- Author
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Morita, K., Tamate, T., Sugimoto, Y., Tago, Y., Watanabe, T., Konaka, H., Sato, M., Miyauchi, Y., Ohkuma, K., and Nagasawa, T.
- Subjects
SALMON ,FEMALES ,LATITUDE ,SPAWNING ,MARINE biology - Abstract
Latitudinal variation in egg size and number in anadromous masu salmon Oncorhynchus masou was examined. Relatively greater variation in egg size occurred among rivers than among females within rivers or within females. Egg size was generally greater and egg number generally lower at more northerly latitudes. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
24. Charmed hadron production in polarized <f>pp</f> reactions as a probe of polarized gluons in the proton
- Author
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Morii, T. and Ohkuma, K.
- Published
- 2003
- Full Text
- View/download PDF
25. A new quadruple therapy for the eradication of Helicobacter pylori. Effect of pretreatment with omeprazole on the cure rate.
- Author
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Okada, Mitsuo, Oki, Koichiro, Shirotani, Takuro, Seo, Mitsuru, Okabe, Nobuo, Maeda, Kazuhiro, Nishimura, Hirokatsu, Ohkuma, Kenji, Oda, Kazuto, Okada, M, Oki, K, Shirotani, T, Seo, M, Okabe, N, Maeda, K, Nishimura, H, Ohkuma, K, and Oda, K
- Subjects
TREATMENT of helicobacter pylori infections ,OMEPRAZOLE ,PEPTIC ulcer ,PATIENTS - Abstract
To elucidate whether pretreatment with omeprazole decreases the cure rate of Helicobacter pylori infection with a new quadruple therapy, and thus, whether this pretreatment should not be used in clinical practice, we conducted a randomized trial. Ninety patients with chronic peptic ulcer disease and nonulcer dyspepsia, with biopsy-proven H. pylori infection were randomly assigned to the two following regimens: Group 1 (n = 45) received omeprazole 20 mg once daily for 2 weeks (days 1-14), and 500 mg amoxicillin granules and 250 mg metronidazole thrice daily, and roxithromycin 150 mg twice daily for 1 week (days 8-14), Group 2 (n = 45) received the same antibiotic treatment as group 1 for 1 week (days 1-7), in addition to omeprazole treatment for 2 weeks (days 1-14). Four weeks after the treatment ended, endoscopy was repeated, with two biopsy specimens each taken from the antrum and the corpus (total of four specimens) for a urease test, histological analysis, and culture to establish cure of infection. A patient was regarded as cured only if all three methods gave negative results for H. pylori. In the intention-to-treat analysis, 42 of 45 patients (93.3%; 95% confidence intervals [CI], 81.7%-98.6%) in group 1 were cured compared with 43 of 45 patients (95.6%; 95% CI, 84.9%-99.5%) in group 2. In the per-protocol analysis, the corresponding figures were 42/44 (95.5%; 95% CI 84.5%-99.4%) and 43/44 (97.7%; 95% CI, 88.0%-99.9%). There were no significant differences in the cure rate between the two groups on either analysis. All patients, except for one who had an allergic reaction, completed the treatment regimens. Fifty to sixty percent of the patients had no side effects while the rest had mild to moderate side effects. The new quadruple therapy consisting of omeprazole, amoxicillin, metronidazole, and roxithromycin appears suitable for use in clinical practice, as the cure rate was 95% and no severe side effects were observed. Pretreatment with omeprazole did not reduce the cure rate for this new quadruple therapy. [ABSTRACT FROM AUTHOR]
- Published
- 1998
- Full Text
- View/download PDF
26. Breast masses with mixed cystic-solid sonographic appearance.
- Author
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Omori, Liria Mariko, Hisa, Naofumi, Ohkuma, Kiyoshi, Fujikura, Yuji, Hiramatsu, Kyoichi, Enomoto, Kouji, Ikeda, Tadashi, Mukai, Makio, Omori, L M, Hisa, N, Ohkuma, K, Fujikura, Y, Hiramatsu, K, Enomoto, I, Ikeda, T, and Mukai, M
- Published
- 1993
- Full Text
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27. Lc+ production in polarized pp scattering and polarized gluon distribution
- Author
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Ohkuma, K., Sudoh, K., and Morii, T.
- Published
- 2000
- Full Text
- View/download PDF
28. Dehydrogenation of ethylbenzene over iron oxide-based catalyst in the presence of carbon dioxide
- Author
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Mimura, N., Takahara, I., Saito, M., Hattori, T., Ohkuma, K., and Ando, M.
- Published
- 1998
- Full Text
- View/download PDF
29. Studying possible anomalous top-quark couplings at photon colliders
- Author
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Bohdan Grzadkowski, Hioki, Z., Ohkuma, K., and Wudka, J.
- Subjects
High Energy Physics - Experiment (hep-ex) ,High Energy Physics - Phenomenology ,High Energy Physics - Phenomenology (hep-ph) ,Astrophysics::High Energy Astrophysical Phenomena ,High Energy Physics::Phenomenology ,FOS: Physical sciences ,High Energy Physics::Experiment ,High Energy Physics - Experiment - Abstract
Search for new-physics through possible anomalous t tbar gamma, tbW and gamma gamma H couplings which are generated by SU(2) X U(1) gauge-invariant dimension-6 effective operators is discussed, using energy and angular distributions of final charged-lepton/ b-quark in gamma gamma -> t tbar -> l X / bX for various beam polarizations. Optimal beam polarizations that minimize uncertainty in determination of those non-standard couplings are found performing an optimal-observable analysis., 12 pages, no figures; v2: Typos corrected
30. Clinical significance of the 'galaxy sign' in patients with pulmonary sarcoidosis in a Japanese single-center cohort
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Koide, T., Saraya, T., Tsukahara, Y., Francesco Bonella, Börner, E., Ishida, M., Ogawa, Y., Hirukawa, I., Oda, M., Shimoda, M., Ohkuma, K., Fujiwara, M., Takata, S., Yokoyama, T., Kurai, D., Ishii, H., Goto, H., and Takizawa, H.
- Subjects
Medizin - Abstract
CA extern
31. Detector concepts
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Aarons, G., Abe, T., Abernathy, J., Ablikim, M., Abramowicz, H., Adey, D., Adloff, C., Adolphsen, C., Afanaciev, K., Agapov, I., Ahn, J. -K, Aihara, H., Akemoto, M., Del Carmenalabau, M., Albert, J., Albrecht, H., Albrecht, M., Alesini, D., Alexander, G., Alexander, J., Allison, W., Amann, J., Amirikas, R., An, Q., Anami, S., Ananthanarayan, B., Anderson, T., Andricek, L., Anduze, M., Anerella, M., Anfimov, N., Angal-Kalinin, D., Antipov, S., Antoine, C., Aoki, M., Aoza, A., Aplin, S., Appleby, R., Arai, Y., Araki, S., Arkan, T., Arnold, N., Arnold, R., Arnowitt, R., Artru, X., Arya, K., Aryshev, A., Asakawa, E., Asiri, F., Asner, D., Atac, M., Atoian, G., Attié, D., Augustin, J. -E, Augustine, D. B., Ayres, B., Aziz, T., Baars, D., Badaud, F., Baddams, N., Bagger, J., Bai, S., Bailey, D., Bailey, I. R., Baker, D., Balalykin, N. I., Balbuena, J. P., Baldy, J. -L, Ball, M., Ballestrero, A., Ballin, J., Baltay, C., Bambade, P., Ban, S., Band, H., Bane, K., Banerjee, B., Barbanotti, S., Barbareschi, D., Barbaro-Galtieri, A., Barber, D. P., Barbi, M., Bardin, D. Y., Barish, B., Barklow, T. L., Barlow, R., Barnes, V. E., Barone, M., Bartels, C., Bartsch, V., Basu, R., Battaglia, M., Batygin, Y., Baudot, J., Baur, U., Baynham, D. E., Beard, C., Bebek, C., Bechtle, P., Becker, U. J., Bedeschi, F., Bedjidian, M., Behera, P., Behnke, T., Bellantoni, L., Bellerive, A., Bellomo, P., Bentson, L. D., Benyamna, M., Bergauer, T., Berger, E., Bergholz, M., Beri, S., Berndt, M., Bernreuther, W., Bertolini, A., Besancon, M., Besson, A., Beteille, A., Bettoni, S., Beyer, M., Bhandari, R. K., Bharadwaj, V., Bhatnagar, V., Bhattacharya, S., Bhattacharyya, G., Bhattacherjee, B., Bhuyan, R., Bi, X. -J, Biagini, M., Bialowons, W., Biebel, O., Bieler, T., Bierwagen, J., Birch, A., Bisset, M., Biswal, S. S., Blackmore, V., Blair, G., Blanchard, G., Blazey, G., Blue, A., Blümlein, J., Boffo, C., Bohn, C., Boiko, V. I., Boisvert, V., Bondarchuk, E. N., Boni, R., Bonvicini, G., Boogert, S., Boonekamp, M., Boorman, G., Borras, K., Bortoletto, D., Bosco, A., Bosio, C., Bosland, P., Bosotti, A., Boudry, V., Boumediene, D. -E, Bouquet, B., Bourov, S., Bowden, G., Bower, G., Boyarski, A., Bozovic-Jelisavcic, I., Bozzi, C., Brachmann, A., Bradshaw, T. W., Brandt, A., Brasser, H. P., Brau, B., Brau, J. E., Breidenbach, M., Bricker, S., Brient, J. -C, Brock, I., Brodsky, S., Brooksby, C., Broome, T. A., Brown, D., Brownell, J. H., Bruchon, M., Brueck, H., Brummitt, A. J., Brun, N., Buchholz, P., Budagov, Y. A., Bulgheroni, A., Bulyak, E., Bungau, A., Bürger, J., Burke, D., Burkhart, C., Burrows, P., Burt, G., Burton, D., Büsser, K., Butler, J., Butterworth, J., Buzulutskov, A., Cabruja, E., Caccia, M., Cai, Y., Calcaterra, A., Caliier, S., Camporesi, T., Cao, J. -J, Cao, J. S., Capatina, O., Cappellini, C., Carcagno, R., Carena, M., Carloganu, C., Carosi, R., Carr, F. S., Carrion, F., Carter, H. F., Carter, J., Carwardine, J., Cassel, R., Cassell, R., Cavallari, G., Cavallo, E., Cembranos, J. A. R., Chakraborty, D., Chandez, F., Charles, M., Chase, B., Chattopadhyay, S., Chauveau, J., Chefdeville, M., Chehab, R., Chel, S., Chelkov, G., Chen, C., Chen, H. S., Chen, H. B., Chen, J. E., Chen, S. Y., Chen, S., Chen, X., Chen, Y. B., Cheng, J., Chevallier, M., Chi, Y. L., Chickering, W., Cho, G. -C, Cho, M. -H, Choi, J. -H, Choi, J. B., Choi, S. Y., Choi, Y. -I, Choudhary, B., Choudhury, D., Choudhury, S. R., Christian, D., Christian, G., Christophe, G., Chung, J. -H, Church, M., Ciborowski, J., Cihangir, S., Ciovati, G., Clarke, C., Clarke, D. G., Clarke, J. A., Clements, E., Coca, C., Coe, P., Cogan, J., Colas, P., Collard, C., Colledani, C., Combaret, C., Comerma, A., Compton, C., Constance, B., Conway, J., Cook, E., Cooke, P., Cooper, W., Corcoran, S., Cornat, R., Corner, L., Gil, E. C., Corvin, W. C., Ramusino, A. C., Cowan, R., Crawford, C., Cremaldi, L. M., Crittenden, J. A., Cussans, D., Cvach, J., Da Silva, W., Khah, H. D., Dabrowski, A., Dabrowski, W., Dadoun, O., Dai, J. P., Dainton, J., Daly, C., Damerell, C., Danilov, M., Daniluk, W., Daram, S., Datta, A., Dauncey, P., David, J., Davier, M., Davies, K. P., Dawson, S., Boer, W., Curtis, S., Groot, N., La Taille, C., Lira, A., Roeck, A., Sangro, R., Santis, S., Deacon, L., Deandrea, A., Klaus Dehmelt, Delagnes, E., Delahaye, J. -P, Delebecque, P., Delerue, N., Delferriere, O., Demarteau, M., Deng, Z., Denisov, Yu N., Densham, C. J., Desch, K., Deshpande, N., Devanz, G., Devetak, E., Dexter, A., Di Benedetto, V., Diéguez, Á, Diener, R., Dinh, N. D., Dixit, M., Dixit, S., Djouadi, A., Dolezal, Z., Dollan, R., Dong, D., Dong, H. Y., Dorfan, J., Dorokhov, A., Doucas, G., Downing, R., Doyle, E., Doziere, G., Drago, A., Dragt, A., Drake, G., Drásal, Z., Dreiner, H., Drell, P., Driouichi, C., Drozhdin, A., Drugakov, V., Du, S., Dugan, G., Duginov, V., Dulinski, W., Dulucq, F., Dutta, S., Dwivedi, J., Dychkant, A., Dzahini, D., Eckerlin, G., Edwards, H., Ehrenfeld, W., Ehrlichman, M., Ehrlichmann, H., Eigen, G., Elagin, A., Elementi, L., Eliasson, P., Ellis, J., Ellwood, G., Elsen, E., Emery, L., Enami, K., Endo, K., Enomoto, A., Eozénou, F., Erbacher, R., Erickson, R., Eyser, K. O., Fadeyev, V., Fang, S. X., Fant, K., Fasso, A., Giannelli, M. F., Fehlberg, J., Feld, L., Feng, J. L., Ferguson, J., Fernandez-Garcia, M., Fernandez-Hernando, J. L., Fiala, P., Fieguth, T., Finch, A., Finocchiaro, G., Fischer, P., Fisher, P., Fisk, H. E., Fitton, M. D., Fleck, I., Fleischer, M., Fleury, J., Flood, K., Foley, M., Ford, R., Fortin, D., Foster, B., Fourches, N., Francis, K., Frey, A., Frey, R., Friedsam, H., Frisch, J., Frishman, A., Fuerst, J., Fujii, K., Fujimoto, J., Fukuda, M., Fukuda, S., Funahashi, Y., Funk, W., Furletova, J., Furukawa, K., Furuta, F., Fusayasu, T., Fuster, J., Gadow, K., Gaede, F., Gaglione, R., Gai, W., Gajewski, J., Galik, R., Galkin, A., Galkin, V., Gallin-Martel, L., Gannaway, F., Gao, J. S., Gao, J., Gao, Y., Garbincius, P., Garcia-Tabares, L., Garren, L., Garrido, L., Garutti, E., Garvey, T., Garwin, E., Gascón, D., Gastal, M., Gatto, C., Gatto, R., Gay, P., Ge, L., Ge, M. Q., Ge, R., Geiser, A., Gellrich, A., Genat, J. -F, Geng, Z. Q., Gentile, S., Gerbick, S., Gerig, R., Ghosh, D. K., Ghosh, K., Gibbons, L., Giganon, A., Gillespie, A., Gillman, T., Ginzburg, I., Giomataris, I., Giunta, M., Gladkikh, P., Gluza, J., Godbole, R., Godfrey, S., Goldhaber, G., Goldstein, J., Gollin, G. D., Gonzalez-Sanchez, F. J., Goodrick, M., Gornushkin, Y., Gostkin, M., Gottschalk, E., Goudket, P., Eschrich, I. G., Gournaris, F., Graciani, R., Graf, N., Grah, C., Grancagnolo, F., Grandjean, D., Grannis, P., Grassellino, A., Graugés, E., Gray, S., Green, M., Greenhalgh, J., Greenshaw, T., Grefe, C., Gregor, I. -M, Grenier, G., Grimes, M., Grimm, T., Gris, P., Grivaz, J. -F, Groll, M., Gronberg, J., Grondin, D., Groom, D., Gross, E., Grunewald, M., Grupen, C., Grzelak, G., Gu, J., Gu, Y. -T, Guchait, M., Guiducci, S., Guler, A. M., Guler, H., Gulmez, E., Gunion, J., Guo, Z. Y., Gurtu, A., Ha, H. B., Haas, T., Haase, A., Haba, N., Haber, H., Haensel, S., Hagge, L., Hagura, H., Hajdu, C., Haller, G., Haller, J., Hallermann, L., Halyo, V., Hamaguchi, K., Hammond, L., Han, L., Han, T., Hand, L., Handu, V. K., Hano, H., Hansen, C., Hansen, J. D., Hansen, J. B., Hara, K., Harder, K., Hartin, A., Hartung, W., Hast, C., Hauptman, J., Hauschild, M., Hauviller, C., Havranek, M., Hawkes, C., Hawkings, R., Hayano, H., Hazumi, M., He, A., He, H. J., Hearty, C., Heath, H., Hebbeker, T., Hedberg, V., Hedin, D., Heifets, S., Heinemeyer, S., Heini, S., Helebrant, C., Helms, R., Heltsley, B., Henrot-Versille, S., Henschel, H., Hensel, C., Hermel, R., Herms, A., Herten, G., Hesselbach, S., Heuer, R. -D, Heusch, C. A., Hewett, J., Higashi, N., Higashi, T., Higashi, Y., Higo, T., Hildreth, M. D., Hiller, K., Hillert, S., Hillier, S. J., Himel, T., Himmi, A., Hinchliffe, I., Hioki, Z., Hirano, K., Hirose, T., Hisamatsu, H., Hisano, J., Hlaing, C. T., Hock, K. M., Hoeferkamp, M., Hohlfeld, M., Honda, Y., Hong, J., Hong, T. M., Honma, H., Horii, Y., Horvath, D., Hosoyama, K., Hostachy, J. -Y, Hou, M., Hou, W. -S, Howell, D., Hronek, M., Hsiung, Y. B., Hu, B., Hu, T., Huang, J. -Y, Huang, T. M., Huang, W. H., Huedem, E., Huggard, P., Hugonie, C., Hu-Guo, C., Huitu, K., Hwang, Y., Idzik, M., Ignatenko, A., Ignatov, F., Ikeda, H., Ikematsu, K., Ilicheva, T., Imbault, D., Imhof, A., Incagli, M., Ingbir, R., Inoue, H., Inoue, Y., Introzzi, G., Ioakeimidi, K., Ishihara, S., Ishikawa, A., Ishikawa, T., Issakov, V., Ito, K., Ivanov, V. V., Ivanov, V., Ivanyushenkov, Y., Iwasaki, M., Iwashita, Y., Jackson, D., Jackson, F., Jacobsen, B., Jaganathan, R., Jamison, S., Janssen, M. E., Jaramillo-Echeverria, R., Jaros, J., Jauffret, C., Jawale, S. B., Jeans, D., Jedziniak, R., Jeffery, B., Jehanno, D., Jenner, L. J., Jensen, C., Jensen, D. R., Jiang, H., Jiang, X. M., Jimbo, M., Jin, S., Jobe, R. K., Johnson, A., Johnson, E., Johnson, M., Johnston, M., Joireman, P., Jokic, S., Jones, J., Jones, R. M., Jongewaard, E., Jönsson, L., Joshi, G., Joshi, S. 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A., Tollefson, K., Tomasek, L., Tomovic, S., Tompkins, J., Tonutti, M., Topkar, A., Toprek, D., Toral, F., Torrence, E., Traversi, G., Trimpl, M., Tripathi, S. M., Trischuk, W., Trodden, M., Trubnikov, G. V., Tschirhart, R., Tskhadadze, E., Tsuchiya, K., Tsukamoto, T., Tsunemi, A., Tucker, R., Turchetta, R., Tyndel, M., Uekusa, N., Ueno, K., Umemori, K., Ummenhofer, M., Underwood, D., Uozumi, S., Urakawa, J., Urban, J., Uriot, D., Urner, D., Ushakov, A., Usher, T., Uzunyan, S., Vachon, B., Valerio, L., Valin, I., Valishev, A., Vamra, R., Graaf, H., Kooten, R., Zandbergen, G., Vanel, J. -C, Variola, A., Varner, G., Velasco, M., Velte, U., Velthuis, J., Vempati, S. K., Venturini, M., Vescovi, C., Videau, H., Vila, I., Vincent, P., Virey, J. -M, Visentin, B., Viti, M., Vo, T. C., Vogel, A., Vogt, H., Toerne, E., Vorozhtsov, S. B., Vos, M., Votava, M., Vrba, V., Wackeroth, D., Wagner, A., Wagner, C. E. M., Wagner, S., Wake, M., Walczak, R., Walker, N. 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M., Zhou, F., Zhou, S., Zhu, S. H., Zhu, X. W., Zhukov, V., Zimmermann, F., Ziolkowski, M., Zisman, M. S., Zomer, F., Zong, Z. G., Zorba, O., and Zutshi, V.
32. Gas-phase ion equilibria studies of protons and chloride ions in propanol and acetone
- Author
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Hiraoka, K., primary, Morise, K., additional, Nishijima, T., additional, Nakamura, S., additional, Nakazato, M., additional, and Ohkuma, K., additional
- Published
- 1986
- Full Text
- View/download PDF
33. Reconstruction-induced mean-square displacements on the (001)-(2×1) surface of diamond-structure crystals
- Author
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Ohkuma, K, primary and Nakamura, K, additional
- Published
- 1979
- Full Text
- View/download PDF
34. High temperature thermopower measurements in impurity-substituted YBa2Cu3O7−y
- Author
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Ohtani, T., primary and Ohkuma, K., additional
- Published
- 1989
- Full Text
- View/download PDF
35. Soliton propagation along optical fibers
- Author
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Ohkuma, K., primary, Ichikawa, Yoshi H., additional, and Abe, Y., additional
- Published
- 1987
- Full Text
- View/download PDF
36. The structure of abscisin II
- Author
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Ohkuma, K., primary, Addicott, F.T., additional, Smith, O.E., additional, and Thiessen, W.E., additional
- Published
- 1965
- Full Text
- View/download PDF
37. Application of pressure swing adsorption to SF/sub 6/ separation and liquefaction from SF/sub 6//N/sub 2/ mixtures
- Author
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Toyoda, M., primary, Murase, H., additional, Inohara, T., additional, Naotsuka, H., additional, Kobayashi, A., additional, Takano, K., additional, and Ohkuma, K., additional
- Full Text
- View/download PDF
38. A hierarchical associative memory consisting of multi-layer associative modules
- Author
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Ohkuma, K., primary
- Full Text
- View/download PDF
39. Nano-fabrication for Evanescent Light Enhancement by Surface Plasmon Polariton for GaP Head of Ultrahigh Density Optical Disk.
- Author
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Goto, K., Ohkuma, K., and Masuda, Y.
- Published
- 2005
- Full Text
- View/download PDF
40. Probing non-standard top-quark couplings via optimal-observable analyses at LHC
- Author
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Hioki Zenrō and Ohkuma Kazumasa
- Subjects
Physics ,QC1-999 - Abstract
Focusing attention on top-quark pair production and its decay processes at the LHC, non-standard top-quark couplings are studied based on the effective Lagrangian constructed with SU(3)×SU(2)×U(1) invariant dimension-6 operators. The optimal-observable analysis is carried out for the charged-lepton distributions in pp → tt̅X → ℓ +X' (ℓ = e or μ) in order to estimate the expected statistical uncertainties in measurements of those non-standard tt̅g and tbW couplings that contribute to this process in the leading order.
- Published
- 2013
- Full Text
- View/download PDF
41. Psychological and weight-related characteristics of patients with anorexia nervosa-restricting type who later develop bulimia nervosa
- Author
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Nagata Katsutaro, Ohkuma Kazuyoshi, Saito Satoshi, Yamaguchi Chikara, Koide Masanori, Okabe Kenjiro, Nishizono Aya, Okamoto Yuri, Nagata Toshihiko, Kawai Keisuke, Oka Takakazu, Nakahara Toshihiro, Ando Tetsuya, Komaki Gen, Nishimura Hiroki, Naruo Tetsuro, Takii Masato, Kiriike Nobuo, and Ishikawa Toshio
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Background Patients with anorexia nervosa-restricting type (AN-R) sometimes develop accompanying bulimic symptoms or the full syndrome of bulimia nervosa (BN). If clinicians could predict who might change into the bulimic sub-type or BN, preventative steps could be taken. Therefore, we investigated anthropometric and psychological factors possibly associated with such changes. Method All participants were from a study by the Japanese Genetic Research Group for Eating Disorders. Of 80 patients initially diagnosed with AN-R, 22 changed to the AN-Binge Eating/Purging Type (AN-BP) and 14 to BN for some period of time. The remaining 44 patients remained AN-R only from the onset to the investigation period. Variables compared by ANOVA included anthropometric measures, personality traits such as Multiple Perfectionism Scale scores and Temperament and Character Inventory scores, and Beck Depression Inventory-II scores. Results In comparison with AN-R only patients, those who developed BN had significantly higher current BMI (p < 0.05) and maximum BMI in the past (p < 0.05). They also scored significantly higher for the psychological characteristic of parental criticism (p < 0.05) and lower in self-directedness (p < 0.05), which confirms previous reports, but these differences disappeared when the depression score was used as a co-variant. No significant differences were obtained for personality traits or depression among the AN-R only patients irrespective of their duration of illness. Conclusion The present findings suggest a tendency toward obesity among patients who cross over from AN-R to BN. Low self-directedness and high parental criticism may be associated with the development of BN by patients with AN-R, although the differences may also be associated with depression.
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- 2008
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42. Application of pressure swing adsorption to SF6 separation and liquefaction from SF6/N2 mixtures.
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Toyoda, M., Murase, H., Inohara, T., Naotsuka, H., Kobayashi, A., Takano, K., and Ohkuma, K.
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- 2000
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43. A hierarchical associative memory consisting of multi-layer associative modules.
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Ohkuma, K.
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- 1993
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44. Development of lightweight and high-strength hollow titanium-plated denture material using three-dimensional printing.
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Igarashi M and Ohkuma K
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- Dental Materials chemistry, Denture Design, Elastic Modulus, Dentures, Surface Properties, Hardness, Dental Stress Analysis, Titanium chemistry, Printing, Three-Dimensional, Materials Testing, Polymethyl Methacrylate chemistry
- Abstract
Owing to its desirable ability to fabricate complex shapes, three-dimensional printing is preferred over casting for manufacturing dentures. Furthermore, titanium is widely used in dental implants and dentures because of its high corrosion resistance, biocompatibility, strength, and low density. In this study, we aimed to develop a new metal denture material from three-dimensional-printed (3DP) to achieve lighter weight and greater strength than those of PMMA dentures. Hollow (3DP-H) structure and solid (3DP-S) structure titanium plate specimens of 0.5, 1.0, and 3.0 mm in thickness were used. Casted Ti, casted Co-Cr, and PMMA plates were fabricated for comparison. Elastic modulus, density, thermal conductivity, hardness, and proof stress of the specimens were measured and plotted on a radar chart to enable multifaceted evaluation. The results indicated that the density of the 3DP-H plates reduced by 28-36% compared with those of 3DP-S and cast Ti plates. The weight of the metal-denture-equivalent section of the 0.5-mm-thick 3DP-H titanium-plated denture reduced to two-thirds that of the 2.0-mm-thick PMMA denture. The proof stress of the 0.5-mm-thick 3DP-H plate increased to about 3 times that of the 2.0-mm-thick PMMA plate. The total value of the 0.5-mm-thick 3DP-H titanium plates was higher than it of the 1.0-mm-thick PMMA plates. This study suggests that it is possible to produce 3DP-H titanium plate dentures exhibiting not only extremely lightweight compared to conventional PMMA dentures but also sufficient strength., (© 2024. The Author(s), under exclusive licence to The Society of The Nippon Dental University.)
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- 2024
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45. Verification of image quality improvement by deep learning reconstruction to 1.5 T MRI in T2-weighted images of the prostate gland.
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Sato Y and Ohkuma K
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- Humans, Male, Adult, Middle Aged, Deep Learning, Magnetic Resonance Imaging methods, Prostate diagnostic imaging, Image Processing, Computer-Assisted methods, Signal-To-Noise Ratio, Quality Improvement
- Abstract
This study aimed to evaluate whether the image quality of 1.5 T magnetic resonance imaging (MRI) of the prostate is equal to or higher than that of 3 T MRI by applying deep learning reconstruction (DLR). To objectively analyze the images from the 13 healthy volunteers, we measured the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the images obtained by the 1.5 T scanner with and without DLR, as well as for images obtained by the 3 T scanner. In the subjective, T2W images of the prostate were visually evaluated by two board-certified radiologists. The SNRs and CNRs in 1.5 T images with DLR were higher than that in 3 T images. Subjective image scores were better for 1.5 T images with DLR than 3 T images. The use of the DLR technique in 1.5 T MRI substantially improved the SNR and image quality of T2W images of the prostate gland, as compared to 3 T MRI., (© 2024. The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics.)
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- 2024
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46. Impact of the COVID-19 pandemic on the glycemic control in people with diabetes mellitus: A retrospective cohort study.
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Ohkuma K, Sawada M, Aihara M, Doi S, Sekine R, Usami S, Ohe K, Kubota N, and Yamauchi T
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- Humans, Hypoglycemic Agents therapeutic use, Glycated Hemoglobin, Blood Glucose, Retrospective Studies, Glycemic Control, Pandemics, Lipids, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 epidemiology, COVID-19 epidemiology, COVID-19 prevention & control
- Abstract
Aim: To investigate the impact of the COVID-19 pandemic and its preventive measures on the glycemic and lipid control in people with diabetes mellitus (DM)., Materials and Methods: We conducted this retrospective cohort study from April 2019 to March 2021; we termed the period from April 2019 to March 2020 as the pre-COVID-19 period, and the period from April 2020 to March 2021 as the COVID-19 period, and divided each of these two periods into four quarters., Results: In the 1st quarter of the COVID period, when the Japanese government declared the first public health emergency, 3,465 people with diabetes mellitus were receiving treatment, which was 10.4% lower than that in the pre-COVID period. The annual mean HbA1c level was significantly elevated in the COVID-19 period. The annual mean total cholesterol (TC) and triglyceride (TG) levels were also significantly higher in the COVID-19 period. Although there were no significant differences in the glycemic control or annual medication between the two periods in people with type 1 diabetes mellitus, the annual mean HbA1c, TC, and TG levels were significantly higher in the COVID-19 period in people with type 2 diabetes mellitus. Furthermore, a significant increase in the percentage of prescriptions for glinides, biguanides, sodium-glucose cotransporter 2 inhibitors, and glucagon-like peptide-1 receptor agonists for people with type 2 diabetes mellitus was observed in the COVID period., Conclusions: It appears from our study that COVID-19 and its preventive measures had a negative impact on the glycemic and lipid control in people with diabetes mellitus., (© 2023 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
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- 2023
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47. Diagnostic accuracy of amniotic fluid interleukin-6 for fetal inflammatory response syndrome.
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Ohkuma K, Ono T, Oshima Y, So K, Tsumura K, Yamasaki F, Nakura Y, Yanagihara I, Nomiyama M, and Yokoyama M
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- Pregnancy, Female, Infant, Newborn, Humans, Amniotic Fluid, Interleukin-6, Retrospective Studies, Inflammation, Gestational Age, Chorioamnionitis diagnosis, Premature Birth, Fetal Membranes, Premature Rupture
- Abstract
Aim: This study aimed to clarify the diagnostic accuracy of amniotic fluid interleukin-6 for fetal inflammatory response syndrome (FIRS)., Methods: This retrospective cohort study was conducted in a single institution and targeted cases of preterm birth within 24 h after amniocentesis among singleton cases that underwent amniocentesis at our hospital for suspected intraamniotic inflammation (IAI) from gestational ages of 22-36 weeks between August 2014 and March 2020. FIRS was defined as >11.0 pg/mL of umbilical cord blood interleukin-6., Results: The analysis included 158 pregnant women. There was a strong correlation between amniotic fluid interleukin-6 and umbilical cord blood interleukin-6 (r = 0.70, p < 0.001). The area under the receiver operating characteristic curve of amniotic fluid interleukin-6 for FIRS was 0.93, with a cutoff value of 15.5 ng/mL, and showed high sensitivity and specificity (0.91 and 0.88, respectively). An amniotic fluid interleukin-6 cutoff value of ≥15.5 ng/mL was associated with a significant risk of FIRS (adjusted odds ratio: 27.9; 95% confidence interval: 6.3-123.0; p < 0.001)., Conclusions: The results of this study show that amniotic interleukin 6 alone can be used to diagnose FIRS prenatally. While there is a need for validation, it may be possible to treat IAI while preventing damage to the central nervous and respiratory systems in the uterus by keeping the amniotic fluid interleukin-6 below the cutoff value., (© 2023 Japan Society of Obstetrics and Gynecology.)
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- 2023
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48. Impact of the COVID-19 pandemic on the glycemic control, eating habits, and body compositions of people with diabetes mellitus: A retrospective longitudinal observational study.
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Sawada M, Ohkuma K, Aihara M, Doi S, Sekine R, Kaneko T, Iimuro S, Ichi I, Usami S, Ohe K, Yamauchi T, and Kubota N
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- Humans, Pandemics, Glycated Hemoglobin, Blood Glucose analysis, Retrospective Studies, Glycemic Control, Body Composition, Feeding Behavior, Diabetes Mellitus, Type 2 complications, COVID-19 epidemiology, COVID-19 complications
- Abstract
Aims/introduction: To evaluate the impact of the COVID-19 pandemic on the glycemic control, eating habits, and body composition of people with diabetes mellitus; to identify the determinants of worsening glycemic control in people with diabetes mellitus., Materials and Methods: This retrospective, longitudinal observational study was performed in outpatients with diabetes mellitus who visited our hospital between April 2019 and March 2020 (pre-COVID-19 period) and continued for follow up from April 2020 to March 2021 (COVID-19 period). We compared the glycemic control, nutritional intakes, and body composition of people with diabetes mellitus between the two periods. The changes in the HbA1c values (ΔHbA1c) and other study variables were compared between the two periods. Logistic regression analysis was performed to identify the factors associated with the increase of HbA1c levels., Results: A significant increase of HbA1c was observed during the COVID-19 period. The percent fat mass (FM) also increased, while the percent skeletal muscle mass (SMM) decreased during the COVID-19 period. After adjustments for age and sex, the ΔBMI (OR:2.33), ΔFM (OR:1.45), and ΔSMM (OR:0.51) were identified as being associated with elevated levels of HbA1c., Conclusions: The COVID-19 pandemic had a negative impact on the glycemic control and body composition of people with diabetes mellitus. The increased body weight and FM and decreased SMM observed during the pandemic were associated with poor glycemic control in people with diabetes mellitus., (© 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
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- 2023
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49. Rationale and design of a multicenter, single-group, open-label trial aiming at investigating the effectiveness of elobixibat for loss of defecation desire in patients with chronic constipation.
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Yamamoto A, Kessoku T, Tanaka K, Takahashi K, Kasai Y, Ozaki A, Iwaki M, Kobayashi T, Yoshihara T, Misawa N, Ohkuma K, Fuyuki A, Higurashi T, Hosono K, Yoneda M, Iwasaki T, Kurihashi T, Nakatogawa M, Suzuki A, Taguri M, Oyamada S, Ariyoshi K, Kobayashi N, Ichikawa Y, and Nakajima A
- Abstract
Background: Approximately 60% of patients with chronic constipation (CC) have a significantly higher rate of loss of defecation desire (LODD). Bile acids are expected to have a restorative effect on defecation desire (DD) because they lower the rectal sensory threshold, which is an objective index of DD. Elobixibat (EXB) specifically inhibits the ileal bile acid transporter/apical sodium-dependent bile acid transporter, which is a transporter involved in the reabsorption of bile acids in the terminal ileum. This study aims to investigate the LODD improvement rate in patients with CC after 4 weeks of EXB treatment., Methods: A total of 40 adult patients with CC who meet the eligibility criteria will be enrolled. Patients will receive oral EXB (10 mg/day) for 4 weeks. A patient diary will be provided daily at 4 weeks after treatment. The primary endpoint will be the percentage LODD improvement at week 4 of the treatment period from week 2 of the observation period using questionnaires., Ethics and Dissemination: Ethical approval was obtained from the Yokohama City University Certified Institutional Review Board prior to participant enrolment (approval number: CRB21-008). The results of this study will be submitted for publication in international peer-reviewed journals, and key findings will be presented at international scientific conferences. Participants desiring the results of this study will be directly contacted for data dissemination., Trial Registration: This trial was registered at ClinicalTrials.gov (NCT05165199)., Protocol Version: 1.0, September 21, 2021., Competing Interests: ANa reports grants and research support from Gilead, Mylan EPD, EA Pharma, Kowa, Taisho, and Biofermin. ANa is a consulting adviser for Gilead, Boehringer Ingelheim, BMS, Kowa, Astellas, EA Pharma, and Mylan EPD. The other authors declare no conflicts of interest., (© 2022 The Authors.)
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- 2022
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50. Diagnostic method for malignant pleural effusion distinguishing malignant mesothelioma from lung cancer using pleural carcinoembryonic antigen and hyaluronic acid levels.
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Saraya T, Ohkuma K, Fujiwara M, and Ishii H
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- Aged, Biomarkers, Tumor blood, Carcinoembryonic Antigen metabolism, Female, Humans, Hyaluronic Acid metabolism, Male, Mesothelioma diagnosis, Middle Aged, Pleural Effusion, Malignant etiology, Retrospective Studies, Carcinoembryonic Antigen blood, Hyaluronic Acid blood, Lung Neoplasms diagnosis, Mesothelioma, Malignant diagnosis, Pleural Effusion, Malignant diagnosis
- Abstract
Abstract: Malignant mesothelioma (MM) is difficult to diagnose because of the lack of parenchymal opacities, often revealing minimal or absent pleural thickening. Furthermore, pleural effusion has diverse differential diagnoses, including malignancies, infections, as well as collagen vascular and other benign diseases. In general practice, lung cancer (LC) is the most common malignancy causing pleural effusion; therefore, a simple method using pleural diagnostic markers to differentiate between LC and mesothelioma is crucial.We retrospectively reviewed the data of 530 adult patients diagnosed with pleural effusion between January 2010 and December 2020 in an outpatient or inpatient setting. Patients with pathologically diagnosed MM or LC with cytologically positive (class IV or V) pleural effusion were analyzed, and the characteristics of these 2 diseases were compared.During the study period, 27 patients diagnosed with MM and 100 patients diagnosed with LC were enrolled. Receiver operating characteristic curve analysis demonstrated that pleural carcinoembryonic antigen (CEA) and hyaluronic acid (HA) could discriminate MM from LC with an area under the curve of 0.925 (95% confidence interval [CI]: 0.879-0.972, P < .001) and 0.815 (95% CI: 0.686-0.943, P < .001), respectively. To diagnose MM, the accuracy of pleural HA >30,000 ng/mL revealed a sensitivity of 75.0%, specificity of 72.6%, and odds ratio of 7.94 (95% CI: 2.5-25.2, P = .001); pleural CEA <6.0 ng/mL revealed a sensitivity of 95.2%, specificity of 84.9%, smaller negative likelihood ratio of 0.06, and odds ratio of 112.5% (95% CI: 14.4-878.1, P < .001). Multiple logistic regression analysis revealed that these 2 parameters could discriminate MM from LC, with a hazard ratio of 23.6 (95% CI: 2.437-228.1, P = .006) and 252.3 (95% Cl: 16.4-3888.1, P < .001), respectively, and their combination had a high specificity of 98.3%.Pleural CEA (≥6.0 ng/mL) can rule out MM with a high degree of certainty, and the positive results for combination of pleural CEA <6.0 ng/mL and HA >30,000 ng/mL can confirm MM with high specificity, prior to cytological or pathological examinations., Competing Interests: The authors have no funding and conflicts of interest to disclose., (Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2022
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