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319 results on '"Ohishi, Waka"'

2. Lenvatinib activates anti-tumor immunity by suppressing immunoinhibitory infiltrates in the tumor microenvironment of advanced hepatocellular carcinoma

Author

Yamauchi, Masami, Ono, Atsushi, Amioka, Kei, Fujii, Yasutoshi, Nakahara, Hikaru, Teraoka, Yuji, Uchikawa, Shinsuke, Fujino, Hatsue, Nakahara, Takashi, Murakami, Eisuke, Okamoto, Wataru, Miki, Daiki, Kawaoka, Tomokazu, Tsuge, Masataka, Imamura, Michio, Hayes, C. Nelson, Ohishi, Waka, Kishi, Takeshi, Kimura, Mizuki, Suzuki, Natsumi, Arihiro, Koji, Aikata, Hiroshi, Chayama, Kazuaki, and Oka, Shiro

Published
2023
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3. Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies

Author

Syrogiannouli, Lamprini, Wildisen, Lea, Meuwese, Christiaan, Bauer, Douglas C, Cappola, Anne R, Gussekloo, Jacobijn, Elzen, Wendy PJ den, Trompet, Stella, Westendorp, Rudi GJ, Jukema, J Wouter, Ferrucci, Luigi, Ceresini, Graziano, Åsvold, Bjørn O, Chaker, Layal, Peeters, Robin P, Imaizumi, Misa, Ohishi, Waka, Vaes, Bert, Völzke, Henry, Sgarbi, Josè A, Walsh, John P, Dullaart, Robin PF, Bakker, Stephan JL, Iacoviello, Massimo, Rodondi, Nicolas, and Del Giovane, Cinzia

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, individual participant data, continuous outcome, non-randomized studies, cohorts, baseline imbalance, Public Health and Health Services, Psychology, Clinical sciences
Abstract

BackgroundIn non-randomized studies (NRSs) where a continuous outcome variable (e.g., depressive symptoms) is assessed at baseline and follow-up, it is common to observe imbalance of the baseline values between the treatment/exposure group and control group. This may bias the study and consequently a meta-analysis (MA) estimate. These estimates may differ across statistical methods used to deal with this issue. Analysis of individual participant data (IPD) allows standardization of methods across studies. We aimed to identify methods used in published IPD-MAs of NRSs for continuous outcomes, and to compare different methods to account for baseline values of outcome variables in IPD-MA of NRSs using two empirical examples from the Thyroid Studies Collaboration (TSC).MethodsFor the first aim we systematically searched in MEDLINE, EMBASE, and Cochrane from inception to February 2021 to identify published IPD-MAs of NRSs that adjusted for baseline outcome measures in the analysis of continuous outcomes. For the second aim, we applied analysis of covariance (ANCOVA), change score, propensity score and the naïve approach (ignores the baseline outcome data) in IPD-MA from NRSs on the association between subclinical hyperthyroidism and depressive symptoms and renal function. We estimated the study and meta-analytic mean difference (MD) and relative standard error (SE). We used both fixed- and random-effects MA.ResultsTen of 18 (56%) of the included studies used the change score method, seven (39%) studies used ANCOVA and one the propensity score (5%). The study estimates were similar across the methods in studies in which groups were balanced at baseline with regard to outcome variables but differed in studies with baseline imbalance. In our empirical examples, ANCOVA and change score showed study results on the same direction, not the propensity score. In our applications, ANCOVA provided more precise estimates, both at study and meta-analytical level, in comparison to other methods. Heterogeneity was higher when change score was used as outcome, moderate for ANCOVA and null with the propensity score.ConclusionANCOVA provided the most precise estimates at both study and meta-analytic level and thus seems preferable in the meta-analysis of IPD from non-randomized studies. For the studies that were well-balanced between groups, change score, and ANCOVA performed similarly.

Published
2022

4. Low thyroid function is not associated with an accelerated deterioration in renal function

Author

Meuwese, Christiaan L, van Diepen, Merel, Cappola, Anne R, Sarnak, Mark J, Shlipak, Michael G, Bauer, Douglas C, Fried, Linda P, Iacoviello, Massimo, Vaes, Bert, Degryse, Jean, Khaw, Kay-Tee, Luben, Robert N, Åsvold, Bjørn O, Bjøro, Trine, Vatten, Lars J, de Craen, Anton JM, Trompet, Stella, Iervasi, Giorgio, Molinaro, Sabrina, Ceresini, Graziano, Ferrucci, Luigi, Dullaart, Robin PF, Bakker, Stephan JL, Jukema, J Wouter, Kearney, Patricia M, Stott, David J, Peeters, Robin P, Franco, Oscar H, Völzke, Henry, Walsh, John P, Bremner, Alexandra, Sgarbi, José A, Maciel, Rui MB, Imaizumi, Misa, Ohishi, Waka, Dekker, Friedo W, Rodondi, Nicolas, Gussekloo, Jacobijn, and Elzen, Wendy PJ den

Subjects
Clinical Research, Kidney Disease, Renal and urogenital, Metabolic and endocrine, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Glomerular Filtration Rate, Humans, Incidence, Longitudinal Studies, Male, Meta-Analysis as Topic, Middle Aged, Netherlands, Prognosis, Renal Insufficiency, Chronic, Thyroid Diseases, Thyroid Function Tests, Thyroid Hormones, chronic renal failure, CKD, creatinine clearance, epidemiology, thyroid function, Thyroid Studies Collaboration, Clinical Sciences, Urology & Nephrology
Abstract

BackgroundChronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups.MethodsIndividual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included. Thyroid hormone status was defined using clinical cut-off values. Estimated glomerular filtration rates (eGFR) were calculated by means of the four-variable Modification of Diet in Renal Disease (MDRD) formula. For this IPD meta-analysis, eGFR at baseline and eGFR change during follow-up were computed by fitting linear regression models and linear mixed models in each cohort separately. Effect estimates were pooled using random effects models.ResultsA total of 72 856 individuals from 16 different cohorts were included. At baseline, individuals with overt hypothyroidism (n = 704) and subclinical hypothyroidism (n = 3356) had a average (95% confidence interval) -4.07 (-6.37 to -1.78) and -2.40 (-3.78 to -1.02) mL/min/1.73 m2 lower eGFR as compared with euthyroid subjects (n = 66 542). In (subclinical) hyperthyroid subjects (n = 2254), average eGFR was 3.01 (1.50-4.52) mL/min/1.73 m2 higher. During 329 713 patient years of follow-up, eGFR did not decline more rapidly in individuals with low thyroid function compared with individuals with normal thyroid function.ConclusionsLow thyroid function is not associated with a deterioration of renal function. The cross-sectional association may be explained by renal dysfunction causing thyroid hormone alterations.

Published
2019

7. Early‐life atomic‐bomb irradiation accelerates immunological aging and elevates immune‐related intracellular reactive oxygen species

Author

Hayashi, Tomonori, primary, Kato, Naohiro, additional, Furudoi, Keiko, additional, Hayashi, Ikue, additional, Kyoizumi, Seishi, additional, Yoshida, Kengo, additional, Kusunoki, Yoichiro, additional, Furukawa, Kyoji, additional, Imaizumi, Misa, additional, Hida, Ayumi, additional, Tanabe, Osamu, additional, and Ohishi, Waka, additional

Published
2023
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9. Naive CD4 T Cells Highly Expressing the Inflammatory Chemokine Receptor CXCR3 Increase with Age and Radiation Exposure in Atomic Bomb Survivors.

Author

Yoshida, Kengo, Misumi, Munechika, Yamaoka, Mika, Kyoizumi, Seishi, Ohishi, Waka, Sugiyama, Hiromi, Hayashi, Tomonori, and Kusunoki, Yoichiro

Subjects
T cells, CHEMOKINE receptors, ATOMIC bomb, IMMUNOSENESCENCE, RADIATION exposure, CD4 antigen
Abstract

The numbers of naive T cells that react to novel pathogens not yet encountered by an immune system, decrease during aging, mainly due to age-associated involution of the thymus. CD45RA+ naive CD4 T cells consist of heterogeneous populations, including highly CXCR3-expressing cells that appear during the homeostatic proliferation of naive T cells and exhibit enhanced type-1 inflammatory phenotypes. Based on previous evidence of radiation-associated reductions in thymic function and peripheral blood naive CD4 T cells, we hypothesized that the homeostatic proliferation of naive CD4 T cells compensates for deficits in peripheral T-cell populations after radiation injury, which may increase the proportion of CXCR3high cells in naive CD4 T cells and enhance inflammation. The statistical models employed in this study revealed positive associations between the number of CXCR3high naive CD4 T cells and age as well as radiation dose among 580 Hiroshima atomic bomb survivors. In addition, the CXCR3high cells in these survivors increased not only with the levels of homeostatic cytokines, IL6 and IL7, but also with those of inflammatory indicators, CXCL10 and CRP. These results suggest that thymic T-cell production deficiency due to radiation and aging results in enhanced homeostatic proliferation that drives the appearance of CXCR3high naive CD4 T cells poised for an inflammatory response. Molecular mechanisms and clinical relevance of increasing CXCR3high cells in naive CD4 T populations should be further investigated in the context of inflammatory disease development long after radiation exposure. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Lenvatinib activates anti-tumor immunity by suppressing immunoinhibitory infiltrates in the tumor microenvironment of advanced hepatocellular carcinoma

Author

Yamauchi, Masami, primary, Ono, Atsushi, additional, Amioka, Kei, additional, Fujii, Yasutoshi, additional, Nakahara, Hikaru, additional, Teraoka, Yuji, additional, Uchikawa, Shinsuke, additional, Fujino, Hatsue, additional, Nakahara, Takashi, additional, Murakami, Eisuke, additional, Okamoto, Wataru, additional, Miki, Daiki, additional, Kawaoka, Tomokazu, additional, Tsuge, Masataka, additional, Imamura, Michio, additional, Hayes, Nelson, additional, Ohishi, Waka, additional, Kishi, Takeshi, additional, Kimura, Mizuki, additional, Suzuki, Natsumi, additional, Arihiro, Koji, additional, Aikata, Hiroshi, additional, Chayama, Kazuaki, additional, and Oka, Shiro, additional

Published
2023
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19. Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies

Author

Lee, Jung Eun, McLerran, Dale F, Rolland, Betsy, Chen, Yu, Grant, Eric J, Vedanthan, Rajesh, Inoue, Manami, Tsugane, Shoichiro, Gao, Yu-Tang, Tsuji, Ichiro, Kakizaki, Masako, Ahsan, Habibul, Ahn, Yoon-Ok, Pan, Wen-Harn, Ozasa, Kotaro, Yoo, Keun-Young, Sasazuki, Shizuka, Yang, Gong, Watanabe, Takashi, Sugawara, Yumi, Parvez, Faruque, Kim, Dong-Hyun, Chuang, Shao-Yuan, Ohishi, Waka, Park, Sue K, Feng, Ziding, Thornquist, Mark, Boffetta, Paolo, Zheng, Wei, Kang, Daehee, Potter, John, and Sinha, Rashmi

Published
2013
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21. Association of body mass index and risk of death from pancreas cancer in Asians : findings from the Asia Cohort Consortium

Author

Lin, Yingsong, Fu, Rong, Grant, Eric, Chen, Yu, Lee, Jung Eun, Gupta, Prakash C., Ramadas, Kunnambath, Inoue, Manami, Tsugane, Shoichiro, Gao, Yu-Tang, Tamakoshi, Akiko, Shu, Xiao-Ou, Ozasa, Kotaro, Tsuji, Ichiro, Kakizaki, Masako, Tanaka, Hideo, Chen, Chien-Jen, Yoo, Keun-Young, Ahn, Yoon-Ok, Ahsan, Habibul, Pednekar, Mangesh S., Sauvaget, Catherine, Sasazuki, Shizuka, Yang, Gong, Xiang, Yong-Bing, Ohishi, Waka, Watanabe, Takashi, Nishino, Yoshikazu, Matsuo, Keitaro, You, San-Lin, Park, Sue K., Kim, Dong-Hyun, Parvez, Faruque, Rolland, Betsy, McLerran, Dale, Sinha, Rashmi, Boffetta, Paolo, Zheng, Wei, Thornquist, Mark, Feng, Ziding, Kang, Daehee, and Potter, John D.

Published
2013

23. Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies

Author

Syrogiannouli, Lamprini, primary, Wildisen, Lea, additional, Meuwese, Christiaan, additional, Bauer, Douglas C., additional, Cappola, Anne R., additional, Gussekloo, Jacobijn, additional, den Elzen, Wendy P. J., additional, Trompet, Stella, additional, Westendorp, Rudi G. J., additional, Jukema, J. Wouter, additional, Ferrucci, Luigi, additional, Ceresini, Graziano, additional, Åsvold, Bjørn O., additional, Chaker, Layal, additional, Peeters, Robin P., additional, Imaizumi, Misa, additional, Ohishi, Waka, additional, Vaes, Bert, additional, Völzke, Henry, additional, Sgarbi, Josè A., additional, Walsh, John P., additional, Dullaart, Robin P. F., additional, Bakker, Stephan J. L., additional, Iacoviello, Massimo, additional, Rodondi, Nicolas, additional, and Del Giovane, Cinzia, additional

Published
2022
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24. Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C

Author

Fujino, Hatsue, Imamura, Michio, Nagaoki, Yuko, Kawakami, Yoshiiku, Abe, Hiromi, Hayes, C. Nelson, Kan, Hiromi, Fukuhara, Takayuki, Kobayashi, Tomoki, Masaki, Keiichi, Ono, Atsushi, Nakahara, Takashi, Honda, Youji, Naeshiro, Noriaki, Urabe, Ayako, Yokoyama, Satoe, Miyaki, Daisuke, Murakami, Eisuke, Kawaoka, Tomokazu, Hiraga, Nobuhiko, Tsuge, Masataka, Hiramatsu, Akira, Hyogo, Hideyuki, Aikata, Hiroshi, Takahashi, Shoichi, Miki, Daiki, Ochi, Hidenori, Ohishi, Waka, Chayama, Kazuaki, and Hiroshima Liver Study Group

Published
2014
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25. Incidence of Diabetes in the Atomic Bomb Survivors: 1969-2015

Author

Tatsukawa, Yoshimi, primary, Cordova, Kismet, additional, Yamada, Michiko, additional, Ohishi, Waka, additional, Imaizumi, Misa, additional, Hida, Ayumi, additional, Sposto, Richard, additional, Sakata, Ritsu, additional, Fujiwara, Saeko, additional, Nakanishi, Shuhei, additional, and Yoneda, Masayasu, additional

Published
2021
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28. Associations of Body Mass Index, Smoking, and Alcohol Consumption With Prostate Cancer Mortality in the Asia Cohort Consortium

Author

Fowke, Jay H., McLerran, Dale F., Gupta, Prakash C., He, Jiang, Shu, Xiao-Ou, Ramadas, Kunnambath, Tsugane, Shoichiro, Inoue, Manami, Tamakoshi, Akiko, Koh, Woon-Puay, Nishino, Yoshikazu, Tsuji, Ichiro, Ozasa, Kotaro, Yuan, Jian-Min, Tanaka, Hideo, Ahn, Yoon-Ok, Chen, Chien-Jen, Sugawara, Yumi, Yoo, Keun-Young, Ahsan, Habibul, Pan, Wen-Harn, Pednekar, Mangesh, Gu, Dongfeng, Xiang, Yong-Bing, Sauvaget, Catherine, Sawada, Norie, Wang, Renwei, Kakizaki, Masako, Tomata, Yasutake, Ohishi, Waka, Butler, Lesley M., Oze, Isao, Kim, Dong-Hyun, You, San-Lin, Park, Sue K., Parvez, Faruque, Chuang, Shao-Yuan, Chen, Yu, Lee, Jung Eun, Grant, Eric, Rolland, Betsy, Thornquist, Mark, Feng, Ziding, Zheng, Wei, Boffetta, Paolo, Sinha, Rashmi, Kang, Daehee, and Potter, John D.

Published
2015
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37. Causal mediation analysis in nested case-control studies using conditional logistic regression

Author

Kim, Young Min, Cologne, John B., Jang, Euna, Lange, Theis, Tatsukawa, Yoshimi, Ohishi, Waka, Utada, Mai, Cullings, Harry M., Kim, Young Min, Cologne, John B., Jang, Euna, Lange, Theis, Tatsukawa, Yoshimi, Ohishi, Waka, Utada, Mai, and Cullings, Harry M.

Abstract

The paper proposes an approach to causal mediation analysis in nested case-control study designs, often incorporated with countermatching schemes using conditional likelihood, and we compare the method's performance to that of mediation analysis using the Cox model for the full cohort with a continuous or dichotomous mediator. Simulation studies are conducted to assess our proposed method and investigate the efficiency relative to the cohort. We illustrate the method using actual data from two studies of potential mediation of radiation risk conducted within the Adult Health Study cohort of atomic-bomb survivors. The performance becomes comparable to that based on the full cohort, illustrating the potential for valid mediation analysis based on the reduced data obtained through the nested case-control design.

Published
2020

39. Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium

Author

Chen, Yu, Copeland, Wade K, Vedanthan, Rajesh, Grant, Eric, Lee, Jung Eun, Gu, Dongfeng, Gupta, Prakash C, Ramadas, Kunnambath, Inoue, Manami, Tsugane, Shoichiro, Tamakoshi, Akiko, Gao, Yu-Tang, Yuan, Jian-Min, Shu, Xiao-Ou, Ozasa, Kotaro, Tsuji, Ichiro, Kakizaki, Masako, Tanaka, Hideo, Nishino, Yoshikazu, Chen, Chien-Jen, Wang, Renwei, Yoo, Keun-Young, Ahn, Yoon-Ok, Ahsan, Habibul, Pan, Wen-Harn, Chen, Chung-Shiuan, Pednekar, Mangesh S, Sauvaget, Catherine, Sasazuki, Shizuka, Yang, Gong, Koh, Woon-Puay, Xiang, Yong-Bing, Ohishi, Waka, Watanabe, Takashi, Sugawara, Yumi, Matsuo, Keitaro, You, San-Lin, Park, Sue K, Kim, Dong-Hyun, Parvez, Faruque, Chuang, Shao-Yuan, Ge, Wenzhen, Rolland, Betsy, McLerran, Dale, Sinha, Rashmi, Thornquist, Mark, Kang, Daehee, Feng, Ziding, Boffetta, Paolo, Zheng, Wei, He, Jiang, and Potter, John D

Published
2013
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47. Modifying Effect of Chronic Atrophic Gastritis on Radiation Risk for Noncardia Gastric Cancer According to Histological Type

Author

Ueda, Keiko, primary, Ohishi, Waka, additional, Cullings, Harry, additional, Fujiwara, Saeko, additional, Suzuki, Gen, additional, Hayashi, Tomonori, additional, Mitsui, Fukiko, additional, Hida, Ayumi, additional, Ozasa, Kotaro, additional, Ito, Masanori, additional, Chayama, Kazuaki, additional, and Tahara, Eiichi, additional

Published
2020
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49. Effects of Radiation on Blood Pressure and Body Weight in the Spontaneously Hypertensive Rat Model. Are Radiation Effects on Blood Pressure Affected by Genetic Background?

Author

Takahashi, Norio, primary, Misumi, Munechika, additional, Niwa, Yasuharu, additional, Murakami, Hideko, additional, Ohishi, Waka, additional, Inaba, Toshiya, additional, Nagamachi, Akiko, additional, Tanaka, Satoshi, additional, Braga Tanaka, Ignacia, additional, and Suzuki, Gen, additional

Published
2020
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50. Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib

Author

Ono, Atsushi, primary, Aikata, Hiroshi, additional, Yamauchi, Masami, additional, Kodama, Kenichiro, additional, Ohishi, Waka, additional, Kishi, Takeshi, additional, Ohya, Kazuki, additional, Teraoka, Yuji, additional, Osawa, Mitsutaka, additional, Fujino, Hatsue, additional, Nakahara, Takashi, additional, Murakami, Eisuke, additional, Miki, Daiki, additional, Kawaoka, Tomokazu, additional, Abe-Chayama, Hiromi, additional, Zhang, Peiyi, additional, Liu, Songyao, additional, Makokha, Grace Naswa, additional, Tsuge, Masataka, additional, Imamura, Michio, additional, Hayes, C. Nelson, additional, and Chayama, Kazuaki, additional

Published
2020
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