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2. Comparative Analysis of Site-Specific N-glycosylation of LAMP1 from Breast Cancer Tissues.

Author

Ohashi, Shoko, Takakura, Daisuke, Kobayashi, Noritoshi, Tokuhisa, Motohiko, Ichikawa, Yasushi, and Kawasaki, Nana

Subjects
*GLYCANS, *BREAST cancer, *GLYCAN structure, *PRINCIPAL components analysis, *SIALIC acids, *GLYCOPROTEIN analysis
Abstract

Glycosylation changes in cancer proteins have been associated with malignant transformation. However, techniques for analyzing site-specific glycosylation changes in target proteins obtained from clinical tissue samples are insufficient. To overcome these problems, we developed a targeted N-glycoproteomic approach consisting of immunoprecipitation, glycopeptide enrichment, LC/MS/MS and structural assignment using commercially available analytical software followed by manual confirmation. This approach was applied to the comparative site-specific glycosylation analysis of lysosome-associated membrane glycoprotein 1 (LAMP1) between breast cancer (BC) tumors and normal tissues adjacent to tumors. Extensive determination of glycan heterogeneity from four N-glycosylation sites (Asn84/103/249/261) in LAMP1 identified 262 glycoforms and revealed remarkable diversity in tumor glycan structures. A significant increase in N-glycoforms with multiple fucoses and sialic acids at Asn84/249 and high-mannose-type glycans at Asn103/261 were observed in the tumor. Principal component analysis revealed that tumors of different subtypes have independent distributions. This approach enables site-specific glycopeptide analysis of target glycoprotein in breast cancer tissue and become a powerful tool for characterizing tumors with different pathological features by their glycan profiles. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Effects of achievement goals on working memory task performance (Experiment 2)

Author

Tanaka, Ayumi, Kawakami, Tasuki, Ohashi, Shoko, and Ikeda, Kenji

Subjects
Achievement goals, Working memory task, CANTAB, Social and Behavioral Sciences
Abstract

Achievement goal theory has been one of the most prominent approaches to motivation in educational research. Various empirical studies have shown that achievement goals can predict a wide range of outcomes, including learning task persistency and effort, the utilization of cognitive and metacognitive strategies in learning, positive and negative affect during the task, and task performance. An increasing number of experimental studies have induced certain achievement goals and tested their effects on task performance. Some researchers have examined the influence of achievement goals on specific cognitive outcomes. However, most studies have addressed only a limited number of goals and not taken full advantage of the theoretical advancements in the achievement goal approach. Moreover, while a wide variety of dependent measures have been used to test the effect of achievement goals, most studies have not explored it using standardized measures. Therefore, this study aims to investigate how four types of achievement goals—mastery-approach, mastery-avoidance, performance-approach, and performance-avoidance goals—affect performance. We aim to do so by utilizing a standardized test battery for working memory.

Published
2022
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7. Genome Analysis in Sick Neonates and Infants: High-yield Phenotypes and Contribution of Small Copy Number Variations

Author

Suzuki, Hisato, primary, Nozaki, Masatoshi, additional, Yoshihashi, Hiroshi, additional, Imagawa, Kazuo, additional, Kajikawa, Daigo, additional, Yamada, Mamiko, additional, Yamaguchi, Yu, additional, Morisada, Naoya, additional, Eguchi, Mayuko, additional, Ohashi, Shoko, additional, Ninomiya, Shinsuke, additional, Seto, Toshiyuki, additional, Tokutomi, Tomoharu, additional, Hida, Mariko, additional, Toyoshima, Katsuaki, additional, Kondo, Masatoshi, additional, Inui, Ayano, additional, Kurosawa, Kenji, additional, Kosaki, Rika, additional, Ito, Yushi, additional, Okamoto, Nobuhiko, additional, Kosaki, Kenjiro, additional, and Takenouchi, Toshiki, additional

Published
2022
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8. Genomic spectra of biliary tract cancer

Author

Nakamura, Hiromi, Arai, Yasuhito, Totoki, Yasushi, Shirota, Tomoki, Elzawahry, Asmaa, Kato, Mamoru, Hama, Natsuko, Hosoda, Fumie, Urushidate, Tomoko, Ohashi, Shoko, Hiraoka, Nobuyoshi, Ojima, Hidenori, Shimada, Kazuaki, Okusaka, Takuji, Kosuge, Tomoo, Miyagawa, Shinichi, and Shibata, Tatsuhiro

Published
2015
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11. Epigenetic landscape influences the liver cancer genome architecture

Author

Hama, Natsuko, primary, Totoki, Yasushi, additional, Miura, Fumihito, additional, Tatsuno, Kenji, additional, Saito-Adachi, Mihoko, additional, Nakamura, Hiromi, additional, Arai, Yasuhito, additional, Hosoda, Fumie, additional, Urushidate, Tomoko, additional, Ohashi, Shoko, additional, Mukai, Wakako, additional, Hiraoka, Nobuyoshi, additional, Aburatani, Hiroyuki, additional, Ito, Takashi, additional, and Shibata, Tatsuhiro, additional

Published
2018
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12. Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of bone

Author

Ogura, Koichi, primary, Hosoda, Fumie, additional, Nakamura, Hiromi, additional, Hama, Natsuko, additional, Totoki, Yasushi, additional, Yoshida, Akihiko, additional, Ohashi, Shoko, additional, Rokutan, Hirofumi, additional, Takai, Erina, additional, Yachida, Shinichi, additional, Kawai, Akira, additional, Tanaka, Sakae, additional, and Shibata, Tatsuhiro, additional

Published
2017
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14. Comprehensive mutation profiling of mucinous gastric carcinoma

Author

Rokutan, Hirofumi, primary, Hosoda, Fumie, additional, Hama, Natsuko, additional, Nakamura, Hiromi, additional, Totoki, Yasushi, additional, Furukawa, Eisaku, additional, Arakawa, Erika, additional, Ohashi, Shoko, additional, Urushidate, Tomoko, additional, Satoh, Hironori, additional, Shimizu, Hiroko, additional, Igarashi, Keiko, additional, Yachida, Shinichi, additional, Katai, Hitoshi, additional, Taniguchi, Hirokazu, additional, Fukayama, Masashi, additional, and Shibata, Tatsuhiro, additional

Published
2016
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15. Erratum: Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

Author

Fujimoto, Akihiro, primary, Furuta, Mayuko, additional, Totoki, Yasushi, additional, Tsunoda, Tatsuhiko, additional, Kato, Mamoru, additional, Shiraishi, Yuichi, additional, Tanaka, Hiroko, additional, Taniguchi, Hiroaki, additional, Kawakami, Yoshiiku, additional, Ueno, Masaki, additional, Gotoh, Kunihito, additional, Ariizumi, Shun-ichi, additional, Wardell, Christopher P, additional, Hayami, Shinya, additional, Nakamura, Toru, additional, Aikata, Hiroshi, additional, Arihiro, Koji, additional, Boroevich, Keith A, additional, Abe, Tetsuo, additional, Nakano, Kaoru, additional, Maejima, Kazuhiro, additional, Sasaki-Oku, Aya, additional, Ohsawa, Ayako, additional, Shibuya, Tetsuo, additional, Nakamura, Hiromi, additional, Hama, Natsuko, additional, Hosoda, Fumie, additional, Arai, Yasuhito, additional, Ohashi, Shoko, additional, Urushidate, Tomoko, additional, Nagae, Genta, additional, Yamamoto, Shogo, additional, Ueda, Hiroki, additional, Tatsuno, Kenji, additional, Ojima, Hidenori, additional, Hiraoka, Nobuyoshi, additional, Okusaka, Takuji, additional, Kubo, Michiaki, additional, Marubashi, Shigeru, additional, Yamada, Terumasa, additional, Hirano, Satoshi, additional, Yamamoto, Masakazu, additional, Ohdan, Hideki, additional, Shimada, Kazuaki, additional, Ishikawa, Osamu, additional, Yamaue, Hiroki, additional, Chayama, Kazuki, additional, Miyano, Satoru, additional, Aburatani, Hiroyuki, additional, Shibata, Tatsuhiro, additional, and Nakagawa, Hidewaki, additional

Published
2016
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16. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

Author

Fujimoto, Akihiro, primary, Furuta, Mayuko, additional, Totoki, Yasushi, additional, Tsunoda, Tatsuhiko, additional, Kato, Mamoru, additional, Shiraishi, Yuichi, additional, Tanaka, Hiroko, additional, Taniguchi, Hiroaki, additional, Kawakami, Yoshiiku, additional, Ueno, Masaki, additional, Gotoh, Kunihito, additional, Ariizumi, Shun-ichi, additional, Wardell, Christopher P, additional, Hayami, Shinya, additional, Nakamura, Toru, additional, Aikata, Hiroshi, additional, Arihiro, Koji, additional, Boroevich, Keith A, additional, Abe, Tetsuo, additional, Nakano, Kaoru, additional, Maejima, Kazuhiro, additional, Sasaki-Oku, Aya, additional, Ohsawa, Ayako, additional, Shibuya, Tetsuo, additional, Nakamura, Hiromi, additional, Hama, Natsuko, additional, Hosoda, Fumie, additional, Arai, Yasuhito, additional, Ohashi, Shoko, additional, Urushidate, Tomoko, additional, Nagae, Genta, additional, Yamamoto, Shogo, additional, Ueda, Hiroki, additional, Tatsuno, Kenji, additional, Ojima, Hidenori, additional, Hiraoka, Nobuyoshi, additional, Okusaka, Takuji, additional, Kubo, Michiaki, additional, Marubashi, Shigeru, additional, Yamada, Terumasa, additional, Hirano, Satoshi, additional, Yamamoto, Masakazu, additional, Ohdan, Hideki, additional, Shimada, Kazuaki, additional, Ishikawa, Osamu, additional, Yamaue, Hiroki, additional, Chayama, Kazuki, additional, Miyano, Satoru, additional, Aburatani, Hiroyuki, additional, Shibata, Tatsuhiro, additional, and Nakagawa, Hidewaki, additional

Published
2016
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17. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

Author

Totoki, Yasushi, primary, Tatsuno, Kenji, additional, Covington, Kyle R, additional, Ueda, Hiroki, additional, Creighton, Chad J, additional, Kato, Mamoru, additional, Tsuji, Shingo, additional, Donehower, Lawrence A, additional, Slagle, Betty L, additional, Nakamura, Hiromi, additional, Yamamoto, Shogo, additional, Shinbrot, Eve, additional, Hama, Natsuko, additional, Lehmkuhl, Megan, additional, Hosoda, Fumie, additional, Arai, Yasuhito, additional, Walker, Kim, additional, Dahdouli, Mahmoud, additional, Gotoh, Kengo, additional, Nagae, Genta, additional, Gingras, Marie-Claude, additional, Muzny, Donna M, additional, Ojima, Hidenori, additional, Shimada, Kazuaki, additional, Midorikawa, Yutaka, additional, Goss, John A, additional, Cotton, Ronald, additional, Hayashi, Akimasa, additional, Shibahara, Junji, additional, Ishikawa, Shumpei, additional, Guiteau, Jacfranz, additional, Tanaka, Mariko, additional, Urushidate, Tomoko, additional, Ohashi, Shoko, additional, Okada, Naoko, additional, Doddapaneni, Harsha, additional, Wang, Min, additional, Zhu, Yiming, additional, Dinh, Huyen, additional, Okusaka, Takuji, additional, Kokudo, Norihiro, additional, Kosuge, Tomoo, additional, Takayama, Tadatoshi, additional, Fukayama, Masashi, additional, Gibbs, Richard A, additional, Wheeler, David A, additional, Aburatani, Hiroyuki, additional, and Shibata, Tatsuhiro, additional

Published
2014
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18. Genomic spectra of biliary tract cancer.

Author

Shibata, Tatsuhiro, Nakamura, Hiromi, Hosoda, Fumie, Elzawahry, Asmaa, Shirota, Tomoki, Totoki, Yasushi, Kato, Mamoru, Kosuge, Tomoo, Hiraoka, Nobuyoshi, Shimada, Kazuaki, Okusaka, Takuji, Hama, Natsuko, Ojima, Hidenori, Arai, Yasuhito, Miyagawa, Shinichi, Ohashi, Shoko, and Urushidate, Tomoko

Subjects
BILIARY tract cancer, MEDICAL genomics, MITOGEN-activated protein kinases, ACTIN, MULTIPLE correspondence analysis (Statistics)
Abstract

The incidence of biliary tract cancer (BTC), including intrahepatic (ICC) and extrahepatic (ECC) cholangiocarcinoma and gallbladder cancer, has increased globally; however, no effective targeted molecular therapies have been approved at the present time. Here we molecularly characterized 260 BTCs and uncovered spectra of genomic alterations that included new potential therapeutic targets. Gradient spectra of mutational signatures with a higher burden of the APOBEC-associated mutation signature were observed in gallbladder cancer and ECC. Thirty-two significantly altered genes, including ELF3, were identified, and nearly 40% of cases harbored targetable genetic alterations. Gene fusions involving FGFR2 and PRKACA or PRKACB preferentially occurred in ICC and ECC, respectively, and the subtype-associated prevalence of actionable growth factor-mediated signals was noteworthy. The subgroup with the poorest prognosis had significant enrichment of hypermutated tumors and a characteristic elevation in the expression of immune checkpoint molecules. Accordingly, immune-modulating therapies might also be potentially promising options for these patients. [ABSTRACT FROM AUTHOR]

Published
2015
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19. Difference in Characteristics of the Rice for Sake Brewing due to Farmers Studies on the Rice for Sake Brewing (Part 2)

Author

WAKAI, Yoshinori, primary, MURATA, Jun-ichi, additional, KIYOKAWA, Yoshifumi, additional, KOMAKI, Haruya, additional, NAKAMURA, Satomi, additional, OHASHI, Shoko, additional, YANAGIUCHI, Toshiyasu, additional, SATO, Yoichi, additional, MAENAKA, Motooki, additional, YONEZU, Hideshi, additional, TONE, Akio, additional, and KONISHI, Yasuo, additional

Published
1989
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