30 results on '"Oh MG"'
Search Results
2. S@FeS 2 Core-Shell Cathode Nanomaterial for Preventing Polysulfides Shuttling and Forming Solid Electrolyte Interphase in High-Rate Li-S Batteries.
- Author
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Kang DG, Azimov F, Seo D, Park G, Oh MG, Lee HG, Lee YJ, Jung HM, and Song SW
- Abstract
Lithium-sulfur (Li-S) battery is a potential next-generation energy storage technology over lithium-ion batteries for high capacity, cost-effective, and environmentally friendly solutions. However, several issues including polysulfides shuttle, low conductivity and limited rate-capability have hampered its practical application. Herein, a new class of cathode active material with perfect core-shell structure is reported, in which sulfur is fully encapsulated by conductivity-enhancing FeS
2 (named as S@FeS2 ), for high-rate application. Surface-stabilized S@FeS2 cathode exhibits a stable cycling performance under 2 - 20 times higher rates (1-2 C, charged in 30-60 min) than standard rates (e.g., 0.1-0.5 C, charged in 2-10 h), without polysulfides shuttle event. Surface analysis results reveal the unprecedented formation of a stable solid electrolyte interphase (SEI) layer on S@FeS2 cathode, which is distinguished from other sulfur-based cathodes that are not able to form the SEI layer. The data suggest that the prevention of polysulfides shuttling is owing to the surface protection effect of FeS2 shell and the SEI layer formation overlying core-shell S@FeS2 . This unique and potential material concept proposed in the present study will give insight into designing a prospective fast charging Li-S battery., (© 2024 The Author(s). Small published by Wiley‐VCH GmbH.)- Published
- 2024
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3. Impact of Forage Sources on Ruminal Bacteriome and Carcass Traits in Hanwoo Steers During the Late Fattening Stages.
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Kang R, Song J, Park JK, Yun S, Lee JH, Ahn JS, Yu C, Kim G, Jeong J, Oh MG, Jo W, Lee W, Tilahun M, and Park T
- Abstract
This study examined the effects of different forage sources on the ruminal bacteriome, growth performance, and carcass characteristics of Hanwoo steers during the fattening stage. In Korea, where high-concentrate feeding is common, selecting suitable forage is crucial for sustainable beef production. Fifteen 23-month-old Hanwoo steers, weighing an average of 679.27 ± 43.60 kg, were fed the following five different forage sources: oat hay (OAT), rye silage (RYE), Italian ryegrass (IRS), barley forage (BAR), and rice straw silage (RSS), alongside 1.5 kg of dry matter concentrate daily for five months. Carcass traits were evaluated post-slaughter, and rumen fluid samples were analyzed using full-length 16S rRNA gene sequencing to determine the bacteriome composition. The forage source significantly affected the alpha-diversity indices and bacteriome biomarkers linked to the feed efficiency and ruminal fermentation. Differences in the backfat thickness and meat yield index were noted, with alpha-diversity indices correlating with carcass traits. The phylum Planctomycetota, especially the family Thermoguttaceae, was linked to nitrogen fixation in high-protein diets like IRS, while the genus Limimorpha emerged as a biomarker for the meat yield. These findings highlight the importance of forage selection during late fattening to optimize beef production, considering diet and bacteriome shifts.
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- 2024
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4. iSCNT embryo culture system for restoration of Cervus nippon hortulorum, presumed to be sika deer in the Korean Peninsula.
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Park YS, Oh MG, and Kim SH
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- Humans, Animals, Swine, Oocytes chemistry, DNA, Mitochondrial genetics, Democratic People's Republic of Korea, Republic of Korea, Deer physiology
- Abstract
Sika deer inhabiting South Korea became extinct when the last individual was captured on Jeju Island in Korea in 1920 owing to the Japanese seawater relief business, but it is believed that the same subspecies (Cervus nippon hortulorum) inhabits North Korea and the Russian Primorskaya state. In our study, mt-DNA was used to analyze the genetic resources of sika deer in the vicinity of the Korean Peninsula to restore the extinct species of continental deer on the Korean Peninsula. In addition, iSCNT was performed using cells to analyze the potential for restoration of extinct species. The somatic cells of sika deer came from tissues of individuals presumed to be Korean Peninsula sika deer inhabiting the neighboring areas of the Primorskaya state and North Korea. After sequencing 5 deer samples through mt-DNA isolation and PCR, BLAST analysis showed high matching rates for Cervus nippon hortulorum. This shows that the sika deer found near the Russian Primorsky Territory, inhabiting the region adjacent to the Korean Peninsula, can be classified as a subspecies of Cervus nippon hortulorum. The method for producing cloned embryos for species restoration confirmed that iSCNT-embryos developed smoothly when using porcine oocytes. In addition, the stimulation of endometrial cells and progesterone in the IVC system expanded the blastocyst cavity and enabled stable development of energy metabolism and morphological changes in the blastocyst. Our results confirmed that the individual presumed to be a continental deer in the Korean Peninsula had the same genotype as Cervus nippon hortulorum, and securing the individual's cell-line could restore the species through replication and produce a stable iSCNT embryo., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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5. Reconstitution of Caruncle Placenta through the 20α-HSD/Casp-3 Apoptotic Pathway during Early Pregnancy in Bovines.
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Lee JH, Oh MG, and Kim SH
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- Animals, Cattle, Female, Pregnancy, Endometrium metabolism, RNA, Messenger genetics, 20-alpha-Hydroxysteroid Dehydrogenase metabolism, Apoptosis, Caspase 3 metabolism, Placenta metabolism, Uterus metabolism
- Abstract
Trophoblast cells of endometrium during bovine pregnancy with different characteristics undergo dynamic changes during uterine remodeling, which can be observed as continuous changes, as P4 secreted by the mother is replaced by placental hormones. In this context, the present study analyzed tissues' morphological changes through uterine apoptosis during early pregnancy. In addition, the expression pattern associated with apoptosis genes and 20α-HSD was determined in the endometrium and caruncle tissues. The localization of 20α-HSD, VEGF, Casp3, and mTOR protein was also determined in endometrium and caruncle during early pregnancy. From around 30 days, caruncle trophoblast cells with very high invasiveness expanded the villus section as the gestation period progressed. The surrounding cells detached and reorganized into new cells. In addition, an analysis of the effect of apoptosis on cell reorganization in the caruncle revealed that the expression of 20α-HSD/Casp-3 signals in the villus section gradually increased from 30 to 90 days. However, on the 30th day, glandular epithelial cells occurred sporadically in the trophoblast cell section. Moreover, the apoptosis of trophoblast cells increased at 90 days. Taken together, the results of the present study show that changes in the uterus during early pregnancy promote changes during later pregnancy by inducing the reorganization through the stimulation of 20α-HSD and Casp-3, promoting uterine and caruncle tissues, unlike cell development mediated by hormone signaling.
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- 2022
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6. Porcine endometrial 3D co-culture: Morphological changes in 3D endometrium tissues according to hormonal changes.
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Kim SH, Park YS, Shin DH, Moon JC, Oh MG, and Yoon JT
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- Animals, Coculture Techniques, Endometrium metabolism, Female, Matrix Metalloproteinase 2 metabolism, Matrix Metalloproteinase 9 metabolism, Stromal Cells drug effects, Stromal Cells metabolism, Swine, Tissue Inhibitor of Metalloproteinase-2 metabolism, Tissue Inhibitor of Metalloproteinase-3 metabolism, Vascular Endothelial Growth Factor A metabolism, Endometrium cytology, Endometrium pathology, Estradiol pharmacology, Progesterone pharmacology, Stromal Cells cytology
- Abstract
Cells cultured as monolayers proliferate well, but do not sustain their differentiation characteristics. Previous studies have investigated the interactions between cells and growth factors or cytokines by establishing either in vivo or in vitro three-dimensional (3D) cultures. Using porcine uterine epithelial cells and endometrial cells, the current study was designed to develop a 3D uterine culture system and investigate the response to hormone treatment. Formation of the 3D uterine model was similar to that of uterus from the group supplemented with calcium and magnesium, and the addition of these ions altered the spectrum of basement membrane degrading enzyme expression and activity. In particular, the epithelial cell junctions in the 3D model most closely resembled those of an actual uterus when the medium was supplemented with calcium and magnesium; the intercellular basement membrane structure was also tall under these conditions. The study confirmed that Casp-3 expression was lowest in the P4 (progesterone) treatment group, and this hormone was the most potent stimulus for formation of the endometrial cell layer. Therefore, the addition of calcium and magnesium plays an important role in the formation of a 3D uterine model, and the addition of P4 hormone mimics uterine thickening by stimulating growth of the epithelial cell layer.
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- 2021
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7. Specific mutations in the genes of MC1R and TYR have an important influence on the determination of pheomelanin pigmentation in Korean native chickens.
- Author
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Nam IS, Oh MG, Nam MS, and Kim WS
- Abstract
Objective: The TYR (Tyrosinase) and MC1R (Melanocortin 1 receptor) genes are recognized as important genes involved in plumage pigmentation in Korean native chickens. Specifically, most color patterns in chicken result from differential expression of the TYR gene. In this study, the co-segregation of the pigmentation and sequence of the TYR and MC1R genes was investigated through intercrosses between red (R1q1), red with black and black plumage color types of native Korean chickens., Materials and Methods: Using DNA, RNA, and tissue by plumage color of each Korean native chickens, the role of major genes in pigmentation of pheomelanin was evaluated. Reverse transcription polymerase chain reaction, sequencing, western blot, and immunohistochemical were performed to determine the effect of TYR and MC1R genes on plumage pigmentation in Korean native chickens., Results: The KCO line (Korean chicken Ogol: Black-line) with an EEC _ genotype exhibited black feathers, whereas red and red mixed with black chicken with EeC genotype exhibited white feathers. There were notable differences between the base sequences of MC1R and TYR in three Korean chicken breeds, with the highest variation in TYR . Perhaps this is the key characteristics of Korean chicken. Further, we analyzed the expression patterns of MC1R and TYR genes in each type of Korea native chicken and observed that TYR expression was high in feather follicle (R1q2) of KCO tissue. However, native red (Korean chicken red) and native red with black (Korean chicken red dark) chickens have increased TYR expression in the tissue. However, the expression of MC1R was much different from that of TYR ., Conclusion: In this study, our results suggest that the differences in position and TYR expression levels exert more influence on plumage pigmentation in native Korean chicken breeds than changes in MC1R expression levels., Competing Interests: The authors declare that they have no conflict of interest., (Copyright: © Journal of Advanced Veterinary and Animal Research.)
- Published
- 2021
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8. Testicular endothelial cells promote self-renewal of spermatogonial stem cells in rats†.
- Author
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Kim YH, Oh MG, Bhang DH, Kim BJ, Jung SE, Kim SM, Dohr G, Kim SU, Ryeom S, and Ryu BY
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- Animals, Cell Culture Techniques, Cell Proliferation, Cell Transplantation, Feeder Cells, Male, Mice, Mice, Inbred C57BL, Rats, Rats, Sprague-Dawley, Adult Germline Stem Cells physiology, Endothelial Cells physiology, Testis cytology
- Abstract
Spermatogonial stem cells (SSCs) are the basis of spermatogenesis in male due to their capability to multiply in numbers by self-renewal and subsequent meiotic processes. However, as SSCs are present in a very small proportion in the testis, in vitro proliferation of undifferentiated SSCs will facilitate the study of germ cell biology. In this study, we investigated the effectiveness of various cell lines as a feeder layer for rat SSCs. Germ cells enriched for SSCs were cultured on feeder layers including SIM mouse embryo-derived thioguanine and ouabain-resistant cells, C166 cells, and mouse and rat testicular endothelial cells (TECs) and their stem cell potential for generating donor-derived colonies and offspring was assessed by transplantation into recipient testes. Rat germ cells cultured on TECs showed increased mRNA and protein levels of undifferentiated spermatogonial markers. Rat SSCs derived from these germ cells underwent spermatogenesis and generated offspring when transplanted into recipients. Collectively, TECs can serve as an effective feeder layer that enhances the proliferative and self-renewal capacity of cultured rat SSCs while preserving their stemness properties., (© The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction.)
- Published
- 2019
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9. Direct modification of spermatogonial stem cells using lentivirus vectors in vivo leads to efficient generation of transgenic rats.
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Kim BJ, Kim YH, Oh MG, Kim KJ, Jung SE, Jin JH, Kim SU, Min KS, and Ryu BY
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- Animals, Green Fluorescent Proteins, Male, Rats, Lentivirus, Rats, Transgenic, Spermatogonia metabolism
- Abstract
Spermatogonial stem cells (SSCs) transmit genetic information to the next progeny in males. Thus, SSCs are a potential target for germline modifications to generate transgenic animals. In this study, we report a technique for the generation of transgenic rats by in vivo manipulation of SSCs with a high success rate. SSCs in juvenile rats were transduced in vivo with high titers of lentivirus harboring enhanced green fluorescent protein and mated with wild-type females to create founder rats. These founder rats expressed the transgene and passed on the transgene with an overall success rate of 50.0%. Subsequent generations of progeny from the founder rats both expressed and passed on the transgene. Thus, direct modification of SSCs in juvenile rats is an effective means of generating transgenic rats through the male germline. This technology could be adapted to larger animals, in which existing methods for gene modification are inadequate or inapplicable, resulting in the generation of transgenic animals in a variety of species., Competing Interests: None
- Published
- 2019
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10. Postcholecystectomy syndrome: symptom clusters after laparoscopic cholecystectomy.
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Kim H, Han IW, Heo JS, Oh MG, Lim CY, Choi YS, and Lee SE
- Abstract
Purpose: Postcholecystectomy syndrome (PCS) is characterized by abdominal symptoms following gallbladder removal. However, there is no consensus for the definition or treatment for PCS. The purpose of this study was to define PCS among various symptoms after laparoscopic cholecystectomy, and to identify risk factors affecting PCS., Methods: This study was conducted at Dongguk University Ilsan Hospital and Chung-Ang University Hospital (2012-2013). Outcomes were assessed using European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire. Symptom cluster for determining PCS was made by factor analysis. Cluster analysis evaluating risk factors of PCS was made by Ward methods and Dentogram., Results: Factor analysis revealed three distinct symptom clusters, those are 'insomnia and financial difficulties (eigenvalue, 1.707; Cronbach α, 0.190),' 'appetite loss and constipation (eigenvalue, 1.413; Cronbach α, 0.480),' and 'right upper quadrant (RUQ) pain and diarrhea (eigenvalue, 1.245; Cronbach α, 0.315).' Among these symptom clusters, the cluster of 'RUQ pain and diarrhea' was determined as PCS. However, we could not find any risk factors between high symptomatic group and low symptomatic group., Conclusion: PCS could consist of RUQ pain and diarrhea. Well-designed prospective trials are needed to determine risk factors of PCS., Competing Interests: CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
- Published
- 2018
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11. Excess intraoperative fluid volume administration is associated with pancreatic fistula after pancreaticoduodenectomy: A retrospective multicenter study.
- Author
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Han IW, Kim H, Heo J, Oh MG, Choi YS, Lee SE, and Lim CS
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- Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Multivariate Analysis, Pancreatic Fistula epidemiology, Prognosis, Proportional Hazards Models, Retrospective Studies, Risk Factors, Survival Analysis, Fluid Therapy adverse effects, Pancreatic Fistula etiology, Pancreaticoduodenectomy adverse effects, Postoperative Complications epidemiology
- Abstract
Recent studies on perioperative fluid administration in patients undergoing pancreaticoduodenectomy (PD) have suggested that increased fluid loads are associated with worse perioperative outcomes. The purpose of this study was to investigate the relationship between intraoperative fluid (IOF) administration and postoperative pancreatic fistula (POPF), and to determine additional risk factors affecting pancreatic fistula in patients undergoing PD.From 2005 to 2014, a total of 182 patients with various periampullary diseases after PD were reviewed retrospectively at Dongguk University Ilsan Hospital, Chung-Ang University Hospital, and Dongnam Institute of Radiological and Medical Sciences. Patients were assigned to high or low IOF groups based on more or less fluid administration for supplementation of estimated blood loss and maintenance volume (12.5 mL/kg/h) than planned, respectively. The associations between IOF administration, pancreatic fistula development, and perioperative outcomes were evaluated.A total of 98 patients were assigned to the high-IOF group, and 84 to the low-IOF group. Risk factors for pancreatic fistula after univariate analysis were assignment to the high-IOF group, higher preoperative serum hemoglobin level, ampullary or bile duct cancer, pylorus preserving PD, small pancreatic duct, duct-to-mucosa pancreatojejunostomy, use of a stent, and mesh application to pancreatojejunal anastomosis. Among these, assignment to the high-IOF group (hazard ratio [HR] = 5.501, 95% CI 1.624-18.632, P = .006) and a small (<4 mm) pancreatic duct (HR = 4.129, 95% CI 1.569-14.658, P = .035) were identified as independent risk factors for the development of pancreatic fistula after multivariate analysis. However, long-term survival rate did not differ according to IOF group or duct size.Excessive IOF volume administration is associated with an increased incidence of pancreatic fistula after pancreaticoduodenectomy.
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- 2017
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12. Coffee consumption is associated with lower serum aminotransferases in the general Korean population and in those at high risk for hepatic disease.
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Oh MG, Han MA, Kim MW, Park CG, Kim YD, and Lee J
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- Adult, Aged, Alcohol Drinking, Female, Humans, Liver enzymology, Male, Middle Aged, Nutrition Surveys, Republic of Korea, Risk Factors, Alanine Transaminase blood, Aspartate Aminotransferases blood, Coffee, Liver Diseases enzymology
- Abstract
Background and Objectives: The favourable effects of coffee on liver enzymes have been reported worldwide. This study investigated the association between coffee consumption and serum aminotransferase concentration in Korean adults., Methods and Study Design: Data were obtained from the fourth and fifth Korea National Health and Nutrition Examination Surveys. Elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentration were defined as >30 IU/L for men and >19 IU/L for women. The risk of elevated ALT and AST according to general characteristics and frequency of coffee consumption were tested by chi-square tests and multiple logistic regression analyses., Results: The prevalence of elevated ALT was 27.4%, 27.8%, and 26.9% in subjects who drank <1, 1, and >=2 times/day, respectively. The proportions of individuals with elevated AST were 32.5%, 33.1%, and 26.7% in subjects who drank <1, 1, and >=2 times/day, respectively. The aORs for elevated ALT and AST were significantly lower in subjects who drank >=2 times of coffee/day than in those who drank <1 time/day (ALT: aOR=0.86, 95% CI=0.79-0.94; AST: aOR=0.83, 95% CI=0.76-0.91). In subgroup analysis, consumption of >=2 times/day was associated with lower ORs for elevated ALT in the high-risk group overall and in the viral hepatitis and obesity subgroups, respectively. In sensitivity analysis, reduced frequency of coffee consumption was associated with an increased risk for elevated liver enzymes, although an association between coffee consumption and elevated ALT was not observed in women or current smokers., Conclusions: Higher coffee consumption was associated with lower risk of elevated aminotransferase concentration in Korean adults.
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- 2016
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13. Effect of polylactic film (Surgi-Wrap) on preventing postoperative ileus after major hepato-pancreato-biliary surgery.
- Author
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Lee CH, Kim H, Han IW, Kim SM, Kwak BS, Baik YH, Park YJ, and Oh MG
- Abstract
Backgrounds/aims: Major hepato-pancreato-biliary (HPB) surgery is usually performed via an open method rather than a laparoscopic method. Postoperative ileus (POI) is a classic complication after open surgery. The purpose of this study was to determine whether polylactic film is useful in the prevention of POI., Methods: A total of 179 patients who underwent major HPB surgery between 2005 and 2014, were retrospectively reviewed. A diagnosis of POI was made by a physical examination, laboratory, and radiological findings. Surgi-Wrap® polylactic film was preferentially used intraperitoneally by surgeons, just before wound closure., Results: Major HPB surgery included pancreatoduodenectomy (n=48), distal or subtotal pancreatectomy (n=24), hepatectomy (n=67), other bile duct or gallbladder operations (n=35), and others (n=5). Although patients with polylactic film showed a significantly lower incidence of POI (n=3, 4.1% vs. n=14, 13.3%, p =0.041), they showed a significantly higher complication rate (n=20, 27.0% vs. n=19, 18.1%, p =0.004), particularly intra-abdominal fluid collection (n=7, 9.4% vs. n=2, 1.9%), and wound infections (n=6, 8.1% vs. n=3, 2.9%), than those who did not receive the film, respectively., Conclusions: Although the polylactic film prevented POI, more complications other than POI were observed. Well-designed randomized controlled trials, using this anti-adhesive product, are needed to evaluate its effect on POI after major HPB surgery.
- Published
- 2016
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14. Effects of Rowachol on prevention of postcholecystectomy pain after laparoscopic cholecystectomy: prospective multicenter randomized controlled trial.
- Author
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Han IW, Kwon OC, Oh MG, Choi YS, and Lee SE
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- Abdominal Pain diagnosis, Abdominal Pain etiology, Administration, Oral, Adult, Aged, Analgesics adverse effects, Chi-Square Distribution, Drug Administration Schedule, Drug Combinations, Female, Gallbladder Diseases diagnosis, Humans, Male, Middle Aged, Monoterpenes adverse effects, Multivariate Analysis, Pain Measurement, Pain, Postoperative diagnosis, Pain, Postoperative etiology, Proportional Hazards Models, Prospective Studies, Republic of Korea, Risk Factors, Single-Blind Method, Surveys and Questionnaires, Time Factors, Treatment Outcome, Abdominal Pain prevention & control, Analgesics administration & dosage, Cholecystectomy, Laparoscopic adverse effects, Gallbladder Diseases surgery, Monoterpenes administration & dosage, Pain, Postoperative prevention & control
- Abstract
Background: Postcholecystectomy pain (PCP) is characterized by abdominal pain after cholecystectomy. However, prevention of PCP is not well known yet. The purpose of this study was to determine whether Rowachol might be useful in preventing PCP., Methods: Between May 2013 and January 2014, a total of 138 patients with gallbladder disease who were scheduled to undergo laparoscopic cholecystectomy were randomly assigned to orally receive 100 mg Rowachol or placebo three times daily for 3 months after surgery. Abdominal pain was assessed using the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire., Results: Incidence of PCP in the placebo group (n = 9, 14.3%) was higher than that in the Rowachol group (n = 3, 4.7%) with statistically marginal significance (P = 0.08). Risk factor analysis implicated PCP with increased difficulty in performing LC, more frequent pathology with acute cholecystitis, and absence of postoperative Rowachol treatment. Multivariate analysis revealed that greater difficulty of laparoscopic cholecystectomy (HR = 5.78, 95% CI 1.36-24.40, P < 0.05), and absence of postoperative Rowachol treatment (HR = 2.54, 95% CI 1.10-10.39, P < 0.05) were independent risk factors for development of PCP., Conclusion: Rowachol might be beneficial for prevention of PCP after laparoscopic cholecystectomy., (Copyright © 2016 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.)
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- 2016
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15. Correction: Petasites japonicus Stimulates the Proliferation of Mouse Spermatogonial Stem Cells.
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Kang HR, Lee YA, Kim YH, Lee DG, Kim BJ, Kim KJ, Kim BG, Oh MG, Han CK, Lee S, and Ryu BY
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- 2015
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16. A Population-Based, Nationwide Cross-Sectional Study on Influenza Vaccination Status among Cancer Survivors in Korea.
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Oh MG, Han MA, Yun NR, Park J, Ryu SY, Kim DM, and Choi SW
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- Adult, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neoplasms etiology, Neoplasms mortality, Nutrition Surveys, Republic of Korea epidemiology, Young Adult, Influenza Vaccines, Influenza, Human prevention & control, Neoplasms epidemiology, Survivors statistics & numerical data, Vaccination statistics & numerical data
- Abstract
Cancer survivors are at increased risk of developing influenza-related complications. The purpose of this study was to investigate the vaccination coverage among cancer survivors in Korea using the Korea National Health and Nutrition Examination Survey (KNHANES). Adult cancer survivors were selected from fourth (2007-2009) and fifth (2010-2012) KNHANES (n = 1156) datasets. General characteristics, cancer-related data, and influenza vaccination status were collected using self-report questionnaires. Chi-square tests and multiple logistic regression analyses were performed to investigate the association between influenza vaccination coverage and associated factors. Overall, 51% of survivors were vaccinated. Vaccine prevalence exceeded 75% in those more than 65 years but was only 26% in survivors aged 19-44. Increasing age, low frequency of alcohol consumption, having poor self-rated health, and having a shorter duration since cancer diagnosis were significant predictors of vaccination status among cancer survivors under 65 years of age. Influenza vaccine coverage remains much lower than recommended among cancer survivors, particularly in the younger age groups. Further study is needed to determine the factors that contribute to the lack of vaccination in cancer survivors, despite their increased risk for influenza.
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- 2015
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17. A purse-string suture at the level of internal inguinal ring, taking only the peritoneum leaving the distal sac: is it enough for inguinal hernia in pediatric patients?
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Lee DY, Baik YH, Kwak BS, Oh MG, and Choi WY
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- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Laparoscopy, Male, Recurrence, Retrospective Studies, Suture Techniques, Treatment Outcome, Hernia, Inguinal surgery, Herniorrhaphy methods, Inguinal Canal surgery, Peritoneum surgery
- Abstract
Purpose: Although laparoscopic surgery in children has expanded in recent years. Laparoscopic hernia repair in children is still debatable. We aimed to summarize and describe our results of laparoscopic inguinal hernia repair and techniques among children., Methods: Between March 2011 and April 2013, 98 children (67 male, 31 female) underwent laparoscopic inguinal hernia repair at the department of surgery. The clinical outcomes were collected retrospectively., Results: The mean follow-up period was 22.6 months. Twelve patients were ex-premature infants and a contralateral patent processus vaginalis (PPV) was present in 37 of the 91 unilateral inguinal hernia patients. There were two postoperative complications (transient hydrocele, umbilical port site infection). The mean operative time was 46 min. Recurrence, metachronous hernia and testicular atrophy were not observed during the follow-up period., Conclusions: Our preliminary experiences suggest that the laparoscopic purse-string suture of internal inguinal opening of hernia sac could be a safe, effective, and reliable alternative for management of pediatric inguinal hernia.
- Published
- 2015
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18. Petasites japonicus Stimulates the Proliferation of Mouse Spermatogonial Stem Cells.
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Kang HR, Lee YA, Kim YH, Lee DG, Kim BJ, Kim KJ, Kim BG, Oh MG, Han CK, Lee S, and Ryu BY
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- Animals, Cell Culture Techniques, Cell Proliferation drug effects, Cells, Cultured, Culture Media, Serum-Free, Fertility drug effects, Male, Mice, Petasites chemistry, Plant Extracts pharmacology, Spermatogonia drug effects, Spermatogonia metabolism, Stem Cells drug effects, Stem Cells metabolism
- Abstract
Oriental natural plants have been used as medical herbs for the treatment of various diseases for over 2,000 years. In this study, we evaluated the effect of several natural plants on the preservation of male fertility by assessing the ability of plant extracts to stimulate spermatogonial stem cell (SSC) proliferation by using a serum-free culture method. In vitro assays showed that Petasites japonicus extracts, especially the butanol fraction, have a significant effect on germ cells proliferation including SSCs. The activity of SSCs cultured in the presence of the Petasites japonicus butanol fraction was confirmed by normal colony formation and spermatogenesis following germ cell transplantation of the treated SSCs. Our findings could lead to the discovery of novel factors that activate SSCs and could be useful for the development of technologies for the prevention of male infertility.
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- 2015
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19. The Prevalence of Vitamin D Deficiency among Cancer Survivors in a Nationwide Survey of the Korean Population.
- Author
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Oh MG, Han MA, Park J, Ryu SY, and Choi SW
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- Adult, Aged, Asian People, Chi-Square Distribution, Comorbidity, Female, Humans, Logistic Models, Male, Middle Aged, Neoplasms epidemiology, Neoplasms ethnology, Nutrition Surveys, Prevalence, Republic of Korea epidemiology, Vitamin D Deficiency epidemiology, Vitamin D Deficiency ethnology, Young Adult, Neoplasms blood, Survivors statistics & numerical data, Vitamin D blood, Vitamin D Deficiency blood
- Abstract
Background: Recent studies have shown that inadequate vitamin D levels are associated with a poor cancer prognosis, but data regarding actual vitamin D levels in cancer survivors are limited. This study investigated the vitamin D levels and prevalence of vitamin D deficiency among Korean cancer survivors compared with non-cancer controls, and identified the factors associated with vitamin D deficiency., Methods: Using the Korea National Health and Nutrition Examination Survey (KNHANES), 915 cancer survivors and 29,694 controls without a history of cancer were selected. Serum 25(OH)D levels were measured; vitamin D deficiency was defined as 25(OH)D levels less than 20 ng/mL. Chi-square tests and multiple logistic regression analyses were used to evaluate the prevalence of vitamin D deficiency and associated factors., Results: Vitamin D deficiency was observed in 62.7% of cancer survivors and 67.1% of controls. Among cancer survivors, vitamin D deficiency was most prevalent among 19-44 year olds (76.2%) and among managers, professionals, and related workers (79.3%). Multiple logistic regression analysis revealed that younger cancer survivors and those who work indoors were predisposed to vitamin D deficiency., Conclusion: Vitamin D deficiency was prevalent among both cancer survivors and controls in Korea. The regular evaluation and management of vitamin D levels is needed for both bone health and general health in cancer survivors.
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- 2015
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20. Assessing activity limitation among cancer survivors in Korea using data from a nationwide survey.
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Oh MG, Han MA, Byeon YM, Bae KM, and Choi SH
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- Adult, Age Factors, Aged, Case-Control Studies, Cross-Sectional Studies, Female, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Prognosis, Republic of Korea, Sex Factors, Surveys and Questionnaires, Young Adult, Activities of Daily Living, Neoplasms psychology, Quality of Life, Survivors psychology
- Abstract
Background: More than 1 million cancer survivors reside in Korea. We here investigated activity limitations of cancer survivors compared to controls without a history of cancer., Materials and Methods: Using the 4th and 5th Korea National Health and Nutrition Examination Survey (2007-2012) data, we identified 1,155 adult cancer survivors. Activity limitations were defined as limitation in activities of daily living, experience of lying in a sickbed, and number of days lying in a sickbed during the last month. Descriptive analysis and multiple logistic regression compared these measures for survivors and controls by sex and age groups., Results: Approximately 29.4% of cancer survivors reported limitation in activities of daily living, 14.6% experienced lying in a sickbed, and 4.3% experienced more than 15 days lying in a sickbed during the last month. After controlling for demographic and health-related factors, cancer survivors were more likely to report activity limitation than controls. The associations were similar across sex and age groups., Conclusions: Cancer survivors have increased activity limitation compared to controls and these limitations persist across sex and age. Targeted interventions and improved management are essential for improving cancer survivor daily life.
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- 2015
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21. Post-polio syndrome and risk factors in korean polio survivors: a baseline survey by telephone interview.
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Bang H, Suh JH, Lee SY, Kim K, Yang EJ, Jung SH, Jang SN, Han SJ, Kim WH, Oh MG, Kim JH, Lee SG, and Lim JY
- Abstract
Objective: To obtain information on the socioeconomic, medical, and functional status of polio survivors, and to use these results as the preliminary data for establishing the middle-aged cohort of polio survivors., Methods: The subjects were recruited based on the medical records of multiple hospitals and centers. They were assessed through a structured questionnaire over the phone. Post-poliomyelitis syndrome (PPS) was identified according to the specified diagnostic criteria. Differences between polio survivors with or without PPS were evaluated, and the risk factors for PPS were analyzed by the odds ratio (OR)., Results: Majority of polio survivors were middle-aged and mean age was 51.2±8.3 years. A total of 188 out of 313 polio survivors met the adopted criteria for PPS based on the symptoms, yielding a prevalence of 61.6%. Mean interval between acute poliomyelitis and the development of PPS was 38.5±11.6 years. Female gender (OR 1.82; confidence interval [CI] 1.09-3.06), the age at onset of poliomyelitis (OR 1.75; CI 1.05-2.94), the use of orthoses or walking aids (OR 2.46; CI 1.44-4.20), and the history of medical treatment for paralysis, pain or gait disturbance (OR 2.62; CI 1.52-4.51) represented independent risk factors for PPS., Conclusion: We found that the majority of Korean polio survivors entered middle age with many medical, functional, and social problems. Female gender, early age of onset of poliomyelitis, the use of orthoses or walking aids, and the history of medical treatment for paralysis, pain or gait disturbance were identified as the significant risk factors for PPS. A comprehensive and multidisciplinary plan should be prepared to manage polio survivors considering their need for health care services and the risk factors for late effects, such as PPS.
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- 2014
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22. The incidence and configuration of the bifid mandibular canal in Koreans by using cone-beam computed tomography.
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Kang JH, Lee KS, Oh MG, Choi HY, Lee SR, Oh SH, Choi YJ, Kim GT, Choi YS, and Hwang EH
- Abstract
Purpose: This study was performed to investigate the incidence and configuration of the bifid mandibular canal in a Korean population by using cone-beam computed tomography (CBCT) imaging., Materials and Methods: CBCT images of 1933 patients (884 male and 1049 female) were evaluated using PSR-9000N and Alphard-Vega 3030 Dental CT units (Asahi Roentgen Ind. Co., Ltd, Kyoto, Japan). Image analysis was performed by using OnDemand3D software (CyberMed Inc., Seoul, Korea). The bifid mandibular canal was identified and classified into four types, namely, the forward canal, buccolingual canal, dental canal, and retromolar canal. Statistical analysis was performed by using the chi-squared test and one-way analysis of variance (ANOVA)., Results: Bifid mandibular canals were observed in 198 (10.2%) of 1933 patients. The most frequently observed type of bifid mandibular canal was the retromolar canal (n=104, rate: 52.5%) without any significant difference among the incidence of each age and gender. The mean diameter of the accessory canal was 1.27 mm (range: 0.27-3.29 mm) without any significant difference among the mean diameter of each type of the bifid mandibular canal. The mean length of the bifid mandibular canals was 14.97mm(range: 2.17-38.8 mm) with only a significant difference between the dental canal and the other types., Conclusion: The bifid mandibular canal is not uncommon in Koreans and has a prevalence of 10.2% as indicated in the present study. It is suggested that a CBCT examination be recommended for detecting a bifid canal.
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- 2014
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23. Health-related quality of life among cancer survivors in Korea: the Korea National Health and Nutrition Examination Survey.
- Author
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Oh MG, Han MA, Park CY, Park SG, and Chung CH
- Subjects
- Adult, Aged, Female, Health Status, Humans, Male, Middle Aged, Republic of Korea epidemiology, Surveys and Questionnaires, Neoplasms, Quality of Life, Survivors statistics & numerical data
- Abstract
Objective: The purpose of this study was to investigate the quality of life among cancer survivors compared with individuals without a history of cancer (noncancer controls) using the Korea National Health and Nutrition Examination Survey., Methods: The study subjects were 783 adult cancer survivors and 36 456 noncancer controls who participated in the third, fourth and fifth Korea National Health and Nutrition Examination Survey. Demographic factors, health-related behavior, clinical characteristics and health-related quality of life were assessed with self-reported questionnaires. The EuroQoL-5Dimension was used to evaluate health-related quality of life. Descriptive statistics and multiple regression analysis were used to compare health-related quality of life between cancer survivors and noncancer controls., Results: About 67% were women and the mean age of the cancer survivors was 60.9 ± 12.4 years. About 52% of survivors were diagnosed with cancer between 45 and 64 years, and more than half of cancer survivors were diagnosed 5 years or less before the interview. The pain/discomfort dimension was the highest reported problem: 43.6% for cancer survivors. The proportion of any reported problem was significantly higher among cancer survivors compared with noncancer controls in terms of mobility (adjusted odds ratio (aOR), 1.56, 95% confidence interval, 1.24-1.97), usual activities (aOR, 1.45, 95% confidence interval, 1.11-1.89), pain/discomfort (aOR, 1.26, 95% confidence interval, 1.04-1.52) and anxiety/depression (aOR, 1.61, 95% confidence interval, 1.29-2.01)., Conclusions: Cancer survivors had a significantly lower quality of life compared with noncancer controls. The pain/discomfort dimension was the highest reported problem in cancer survivors.
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- 2014
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24. Family history and survival of patients with gastric cancer: a meta-analysis.
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Oh MG, Kim JH, Han MA, Park J, Ryu SY, and Choi SW
- Subjects
- Adenocarcinoma genetics, Carcinoma genetics, Colorectal Neoplasms genetics, Esophageal Neoplasms genetics, Humans, Prognosis, Proportional Hazards Models, Stomach Neoplasms genetics, Adenocarcinoma mortality, Stomach Neoplasms mortality
- Abstract
Background: Previous studies have generated conflicting evidence regarding associations between family history and survival after gastric cancer surgery. In this study, we investigated this question using a meta-analysis., Materials and Methods: To identify relevant studies, PubMed and Embase databases were searched up to June 2013. Two reviewers independently assessed search results and data extraction of included studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS) were calculated based on fixed- or random- effects models. Homogeneity of effects across studies was assessed using x2 test statistics and quantified by I2., Results: A total of five studies were selected according to the inclusion criteria. The total number of patients included was 2,030, which ranged from 145 to 598 per study. There was no significant difference in OS by family history of cancer (HR=0.83, 95%CIs=0.50-1.38), but subgroup analysis of patients with a first-degree family history of cancer (HR=0.74, 95%CIs=0.60-0.93) and gastric cancer family history (HR=0.56, 95%CIs=0.41-0.76) tended to show better OS in these patients., Conclusions: This meta-analysis suggests that a first-degree family history of cancer or gastric cancer family history is associated with better survival of gastric cancer patients after surgery, after a systematic review of five previous studies. These results can be applied by clinicians when counselling patients regarding their risk of death from gastric cancer. Further study is needed to investigate the underlying mechanism between family history and survival in gastric cancer patients.
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- 2014
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25. Health behaviors of cancer survivors: the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV, 2007-09).
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Oh MG, Han MA, Park J, Ryu SY, Park CY, and Choi SW
- Subjects
- Adult, Aged, Breast Neoplasms, Cross-Sectional Studies, Female, Humans, Korea epidemiology, Logistic Models, Male, Middle Aged, Nutrition Surveys, Secondary Prevention, Stomach Neoplasms, Uterine Cervical Neoplasms, Alcohol Drinking epidemiology, Early Detection of Cancer statistics & numerical data, Health Behavior, Motor Activity, Neoplasms prevention & control, Smoking epidemiology, Survivors statistics & numerical data
- Abstract
Objective: This study aimed to describe the health behaviors of cancer survivors in the Republic of Korea and to compare them with the health behaviors of two control groups: (i) individuals with no history of cancer but with other chronic diseases and (ii) individuals with no history of cancer or other chronic diseases., Methods: This is a cross-sectional study of 17 311 adults at least 19 years of age who participated in the Fourth Korea National Health and Nutrition Examination Survey (2007-09). Smoking, alcohol drinking, physical activity and cancer screening behaviors of cancer survivors were assessed and compared with those of the two control groups. χ(2) tests and multiple logistic regression analyses were performed to determine the likelihood and predictors of health behaviors., Results: The proportion of cancer survivors who were current smokers, heavy drinkers and engaged in physical activity were 9.6, 6.6 and 26.0%, respectively. Cancer screening rates reported among survivors were 44.2, 17.0, 49.8 and 47.7% for stomach, colorectal, breast and cervical cancers, respectively. Cancer survivors showed lower smoking and alcohol drinking rates compared with both control groups after adjusting for sex, age, marital status, education, household income and health insurance. Cancer survivors also showed stomach, breast and cervical cancer screening rates that differed from both control groups. However, in multiple analyses, these differences were not significant., Conclusions: Cancer survivors are more likely to adopt good health behaviors than individuals without a history of cancer. Further study is needed to determine the factors that lead to continued unhealthy behaviors after cancer diagnosis.
- Published
- 2013
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26. Association of smoking history with cancer recurrence and survival in stage III-IV male gastric cancer patients.
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Han MA, Kim YW, Choi IJ, Oh MG, Kim CG, Lee JY, Cho SJ, Eom BW, Yoon HM, and Ryu KW
- Subjects
- Adenocarcinoma etiology, Adenocarcinoma pathology, Aged, Aged, 80 and over, Alcohol Drinking epidemiology, Alcohol Drinking pathology, Disease-Free Survival, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Proportional Hazards Models, Republic of Korea epidemiology, Retrospective Studies, Risk Factors, Smoking adverse effects, Stomach Neoplasms etiology, Stomach Neoplasms pathology, Survival Analysis, Adenocarcinoma epidemiology, Smoking epidemiology, Stomach Neoplasms epidemiology
- Abstract
Background: Smoking and drinking alcohol are major risk factors for cancer development, and we investigated their effects on gastric cancer prognosis following initial resection., Methods: Data from male patients with stage III-IV gastric adenocarcinoma who underwent surgery between 2001 and 2006 were retrospectively reviewed. Patients were followed up until 2011. Kaplan-Meier plots and Cox proportional hazards regressions were applied for survival rates., Results: Among 238 patients, 151 (63.4%) smoked and 146 (61.3%) drank alcohol. Current smokers had an increased risk of cancer recurrence or death from any cause [adjusted HR (aHR), 1.94; 95% confidence interval (CI), 1.18-3.21], cancer recurrence (aHR, 1.89; 95% CI, 1.12-3.21), and overall mortality (aHR, 2.14; 95% CI, 1.23-3.73) compared with never-smokers. Patients with a lifetime cigarette smoking of <40 and ≥ 40 pack-years had increased cancer recurrence or death from any cause (aHR, 1.72 and 2.43, respectively; 95% CI, 1.03-2.86 and 1.38-4.30, respectively), cancer recurrence (aHR, 1.63 and 2.61, respectively; 95% CI, 0.95-2.79 and 1.43-4.77, respectively), and overall mortality (aHR, 1.92 and 2.75, respectively; 95% CI, 1.09-3.38 and 1.47-5.12, respectively) compared with never-smokers. However, drinking alcohol was not associated with postsurgery survival., Conclusions: Cigarette-smoking history at the time of diagnosis, but not drinking history, is associated with cancer recurrence and poor survival after surgery in male patients with stage III-IV gastric cancer., Impact: These findings encourage physicians to advise patients with gastric cancer to stop smoking to obtain a general health benefit and likely improvement in the gastric cancer course.
- Published
- 2013
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27. Multiple primary malignant neoplasms in pancreatic cancer patients: a single-center experience in Korea.
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Han MA, Oh MG, Woo SM, Lee WJ, Park SJ, Han SS, Koh YH, Kim TH, Hong EK, Park S, Park JW, and Kim CM
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- Adult, Aged, Aged, 80 and over, Carcinoma, Acinar Cell epidemiology, Carcinoma, Pancreatic Ductal epidemiology, Digestive System Neoplasms diagnosis, Digestive System Neoplasms epidemiology, Female, Humans, Male, Middle Aged, Neoplasms, Second Primary epidemiology, Pancreatic Neoplasms epidemiology, Republic of Korea epidemiology, Carcinoma, Acinar Cell diagnosis, Carcinoma, Pancreatic Ductal diagnosis, Neoplasms, Second Primary diagnosis, Pancreatic Neoplasms diagnosis
- Published
- 2012
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28. [A spongiform mass in the stomach: pyloric gland adenoma with a transition to adenocarcinoma].
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Oh MG, Cho SJ, Lee JH, Kook MC, and Park SY
- Subjects
- Adenocarcinoma pathology, Adenocarcinoma surgery, Adenoma pathology, Adenoma surgery, Aged, Female, Gastroscopy, Humans, Stomach Neoplasms pathology, Stomach Neoplasms surgery, Tomography, X-Ray Computed, Adenocarcinoma diagnosis, Adenoma diagnosis, Gastric Mucosa pathology, Stomach Neoplasms diagnosis
- Published
- 2010
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29. Evaluative processing of ambivalent stimuli in patients with schizophrenia and depression: a [15O] H2O PET study.
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Kim JJ, Park HJ, Jung YC, Chun JW, Kim HS, Seok JH, Kim NW, Park IH, Oh MG, and Lee JD
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- Adult, Brain diagnostic imaging, Brain pathology, Brain Mapping, Choice Behavior physiology, Comprehension physiology, Female, Functional Laterality physiology, Humans, Male, Neuropsychological Tests, Oxygen Isotopes, Positron-Emission Tomography methods, Schizophrenia physiopathology, Statistics as Topic, Water, Young Adult, Decision Making physiology, Depression diagnostic imaging, Depression physiopathology, Schizophrenia diagnostic imaging, Schizophrenic Psychology
- Abstract
Decision making in an emotionally conflicting situation is important in social life. We aimed to address the similarity and disparity of neural correlates involved in processing ambivalent stimuli in patients with schizophrenia and patients with depression. Behavioral task-related hemodynamic responses were measured using [15O]H2O positron emission tomography (PET) in 12 patients with schizophrenia and 12 patients with depression. The task was a modified word-stem completion task, which was designed to evoke ambivalence in forced and non-forced choice conditions. The prefrontal cortex and the cerebellum were found to show increased activity in the healthy control group. In the schizophrenia group, activity in these two regions was negligible. In the depression group, the pattern of activity was altered and a functional compensatory recruitment of the inferior parietal regions was suggested. The prefrontal cortex seems to be associated with the cognitive control to resolve the conflict toward the ambivalent stimuli, whereas the cerebellum reflects the sustained working memory to search for compromise alternatives. The deficit of cerebellar activation in the schizophrenia group might underlie the inability to search and consider compromising responses for conflict resolution.
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- 2009
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30. Reciprocal activation of the orbitofrontal cortex and the ventrolateral prefrontal cortex in processing ambivalent stimuli.
- Author
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Jung YC, Park HJ, Kim JJ, Chun JW, Kim HS, Kim NW, Son SJ, Oh MG, and Lee JD
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- Adult, Female, Frontal Lobe diagnostic imaging, Humans, Male, Models, Statistical, Perception, Positron-Emission Tomography, Prefrontal Cortex diagnostic imaging, Reading, Semantics, Young Adult, Emotions, Frontal Lobe physiology, Prefrontal Cortex physiology
- Abstract
The neural basis of ambivalence has not yet been identified. We investigated the prefrontal cortical activations implicated in evaluative processing of ambivalent stimuli under the forced and non-forced response conditions. Cerebral blood flow was measured using H(2)(15)O positron emission tomography in twelve normal volunteers during a modified word-stem completion task that was designed to evoke different conditions of ambivalence. The prefrontal cortical activations were restricted to the orbitofrontal cortex during the non-forced ambivalent condition, whereas the ventrolateral prefrontal cortex and the frontopolar cortex were activated in addition to the orbitofrontal cortex during the forced ambivalent condition. It is remarkable that the orbitofrontal cortex and the ventrolateral prefrontal cortex demonstrated a reciprocal activation pattern, which might be linked to the evaluative attitude toward the ambivalent stimuli.
- Published
- 2008
- Full Text
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