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199 results on '"Oh, Se‐Jeong"'

2. An observational, prospective, open label, multicenter study to evaluate the safety and effectiveness of pegfilgrastim as secondary prophylaxis to decrease the incidence of febrile neutropenia in Korean female patients with breast cancer

Author

Lee, Anbok, Kang, Taewoo, Kang, Su Hwan, Park, Woo-Chan, Lim, Woosung, Chang, Myung-Chul, Kim, Hyun Yul, Song, Jeong-yoon, Lee, Jihyoun, Byun, Kyung Do, Kim, Hyun-Ah, Son, Gil Soo, Kim, Ju-Yeon, Oh, Se Jeong, Chung, Min Sung, Choi, Young Jin, Shin, Hyuk-Jai, Baek, Jong Min, Yoo, Youngbum, Um, Eunhae, Choi, Jin Hyuk, Kwak, Beom Seok, Park, Min Ho, Lee, Suok Hyun, Kim, Cheol Seung, Lee, Ilkyun, Kim, Je-Ryong, Lee, Han Shin, and Lim, Cheol Wan

Published
2023
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4. Metastasis‐enhancing protein KITENIN confers temozolomide resistance on glioblastoma with unmethylated MGMT via upregulation of cancer stem cell makers.

Author

Ahn, Eun‐Jung, Kim, Yeong Jin, Akanda, Md Rashedunnabi, Oh, Se‐Jeong, Jung, Tae‐Young, Jung, Shin, Lee, Jae‐Hyuk, Kim, Sung Sun, Jeong, Yong Yeon, Ha, Hyung‐Ho, Hyun, Hoon, Kim, Hangun, Rhee, Joon Haeng, Kim, Kyung Keun, Lee, Kyung‐Hwa, and Moon, Kyung‐Sub

Subjects
METHYLGUANINE, REVERSE transcriptase polymerase chain reaction, GENE expression, CANCER stem cells, ALDEHYDE dehydrogenase, WESTERN immunoblotting
Abstract

This article explores the role of the protein KITENIN in promoting resistance to the chemotherapy drug temozolomide (TMZ) in glioblastoma (GBM) patients with unmethylated MGMT promoter status. The study reveals that KITENIN enhances resistance to TMZ by increasing the expression of cancer stem cell markers CD44 and ALDH1A1. The researchers also investigate the use of usnic acid (UA), a KITENIN inhibitor, and find that it reduces KITENIN expression and inhibits tumor growth. The study concludes that targeting KITENIN could potentially improve treatment outcomes for GBM patients with unmethylated MGMT. [Extracted from the article]

Published
2024
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10. Poor Prognosis of Lower Inner Quadrant in Lymph Node–negative Breast Cancer Patients Who Received No Chemotherapy: A Study Based on Nationwide Korean Breast Cancer Registry Database

Author

Ahn, Sei Hyun, Noh, Dong-Young, Nam, Seok Jin, Lee, Eun Sook, Park, Byeong-Woo, Noh, Woo Chul, Yoon, Jung Han, Lee, Soo Jung, Lee, Eun Kyu, Jeong, Joon, Han, Sehwan, Park, Ho Yong, Paik, Nam-Sun, Bae, Young Tae, Lee, Hyouk Jin, Park, Heung Kyu, Ko, Seung Sang, Song, Byung Joo, Suh, Young Jin, Jung, Sung Hoo, Cho, Se Heon, Kim, Sei Joong, Oh, Se Jeong, Ko, Byung Kyun, Kim, Ku Sang, Park, Chanheun, Baek, Jong-Min, Hwang, Ki-Tae, Chang, Il-Sung, Bae, Jeoung Won, Kim, Jeong-Soo, Kang, Sun Hee, Gwak, Geumhee, Lee, Jee Hyun, Kim, Tae Hyun, Chang, Myungchul, Kim, Sung Yong, Lee, Jung Sun, Song, Jeong-Yoon, Park, Hai Lin, Min, Sun Young, Yang, Jung-Hyun, Park, Sung Hwan, Park, Woo-Chan, Kim, Lee Su, Ryu, Dong Won, Kim, Kweon Cheon, Chung, Min Sung, Park, Hee Boong, Lim, Cheol Wan, Choi, Un Jong, Kwak, Beom Seok, Park, Young Sam, Shin, Hyuk Jai, Choi, Young Jin, Kim, Doyil, Han, Airi, Koh, Jong Hyun, Choi, Sangyong, Yoon, Daesung, Choi, Soo Youn, Chul, Shin Hee, Kim, Jae Il, Choi, Jae Hyuck, Ryu, Jin Woo, Ko, Chang Dae, Lee, Il Kyun, Lee, Dong Seok, Choi, Seunghye, Min, Youn Ki, Jeon, Young San, Park, Eun-Hwa, Kim, Jongjin, Kim, Eun-Kyu, Sohn, Guiyun, Kim, Seung Il, Park, Jin Hyun, and Oh, Sohee

Published
2017
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22. Clinical implication of subcategorizing T2 category into T2a and T2b in TNM staging of breast cancer

Author

Jung, Jiwoong, Suh, Young Jin, Ko, Byung Kyun, Lee, Eun Sook, Kim, Eun‐Kyu, Paik, Nam Sun, Byun, Kyung Do, Hwang, Ki‐Tae, Ahn, Sei Hyun, Noh, Dong‐Young, Nam, Seok Jin, Park, Byeong‐Woo, Noh, Woo Chul, Yoon, Jung Han, Lee, Soo Jung, Lee, Eun Kyu, Jeong, Joon, Han, Sehwan, Park, Ho Yong, Paik, Nam‐Sun, Bae, Young Tae, Lee, Hyouk Jin, Park, Heung kyu, Ko, Seung Sang, Park, Woo‐Chan, Jung, Sung Hoo, Cho, Se Heon, Kim, Sei Joong, Oh, Se Jeong, Kim, Ku Sang, Park, Chanheun, Song, Byung Joo, Kim, Je Ryong, Bae, Jeoung Won, Kim, Jeong‐Soo, Kang, Sun Hee, Gwak, Geumhee, Lee, Jee Hyun, Kim, Tae Hyun, Chang, Myungchul, Kim, Sung Yong, Lee, Jung Sun, Song, Jeong‐Yoon, Park, Hai Lin, Min, Sun Young, Yang, Jung‐Hyun, Park, Sung Hwan, Baek, Jong‐Min, Kim, Lee Su, Ryu, Dong Won, Kim, Kweon Cheon, Chung, Min Sung, Park, Hee Boong, Lim, Cheol Wan, Choi, Un Jong, Kwak, Beom Seok, Park, Young Sam, Shin, Hyuk Jai, Choi, Young Jin, Kim, Doyil, Han, Airi, Koh, Jong Hyun, Choi, Sangyong, Yoon, Daesung, Choi, Soo Youn, Chul, Shin Hee, Kim, Jae Il, Choi, Jae Hyuck, Ryu, Jin Woo, Ko, Chang Dae, Lee, Il Kyun, Lee, Dong Seok, Choi, Seunghye, Min, Youn Ki, Jeon, Young San, and Park, Eun‐Hwa

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Multivariate analysis, TNM staging, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, Adjuvant therapy, breast neoplasms, Cutoff, Medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Original Research, Neoplasm Staging, Subcategory, Receiver operating characteristic, business.industry, Hazard ratio, Clinical Cancer Research, tumor staging, Middle Aged, medicine.disease, Tumor Burden, 030220 oncology & carcinogenesis, TNM Staging, Female, prognosis, business
Abstract

Regarding TNM staging in breast cancer, T2 category is currently not divided into subcategories even though it covers a wider range of tumor sizes than T1 category. Using Korean Breast Cancer Registry database, data of 41 071 women diagnosed as non‐metastatic T2 breast cancer between 2001 and 2014 were analyzed. Cutoff value for optimal tumor size was approximated by receiver operating characteristic (ROC) curve to subcategorize T2 tumors. Overall survival (OS) was compared between two subcategories. Median follow‐up period was 65 months. Of 41 071 patients, 4504 (11.0%) died. Based on ROC curve analysis, 3.0 cm was selected as the cutoff value. Five‐year OS rate was 91% in patients with breast tumors ≤3.0 cm (T2a) and 86% in patients with breast tumors >3.0 cm (T2b) (log‐rank P

Published
2018

28. In vivo imaging of invasive aspergillosis with 18F-fluorodeoxysorbitol positron emission tomography.

Author

Kim, Dong-Yeon, Pyo, Ayoung, Ji, Sehyeon, You, Sung-Hwan, Kim, Seong Eun, Lim, Daejin, Kim, Heejung, Lee, Kyung-Hwa, Oh, Se-Jeong, Jung, Ye-rim, Kim, Uh Jin, Jeon, Subin, Kwon, Seong Young, Kang, Sae-Ryung, Lee, Hyang Burm, Hyun, Hoon, Kim, So-Young, Moon, Kyung-Sub, Lee, Sunwoo, and Kang, Seung Ji

Subjects
POSITRON emission tomography, ASPERGILLOSIS, PULMONARY aspergillosis, LUNGS, STAPHYLOCOCCUS aureus infections, ASPERGILLUS fumigatus, INVASIVE diagnosis, LUNG infections
Abstract

Invasive aspergillosis is a critical complication in immunocompromised patients with hematologic malignancies or with viral pneumonia caused by influenza virus or SARS‑CoV‑2. Although early and accurate diagnosis of invasive aspergillosis can maximize clinical outcomes, current diagnostic methods are time-consuming and poorly sensitive. Here, we assess the ability of 2-deoxy-2-18F-fluorosorbitol (18F-FDS) positron emission tomography (PET) to specifically and noninvasively detect Aspergillus infections. We show that 18F-FDS PET can be used to visualize Aspergillus fumigatus infection of the lungs, brain, and muscles in mouse models. In particular, 18F-FDS can distinguish pulmonary aspergillosis from Staphylococcus aureus infection, both of which induce pulmonary infiltrates in immunocompromised patients. Thus, our results indicate that the combination of 18F-FDS PET and appropriate clinical information may be useful in the differential diagnosis and localization of invasive aspergillosis. Current diagnostic methods for invasive aspergillosis are time-consuming and poorly sensitive. Here, the authors show that positron emission tomography with 2-deoxy-2-18F-fluorosorbitol can visualize Aspergillus fumigatus infection of the lungs, brain and muscles in mouse models, and can distinguish pulmonary aspergillosis from other diseases such as Staphylococcus aureus infection and lung cancer. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Response to neoadjuvant chemotherapy based on pathologic complete response in very young patients with ER-positive breast cancer: a large, multicenter, observational study.

Author

Joohyun Woo, Se Jeong Oh, Jeong-Yoon Song, Byung Joo Chae, Jung Eun Choi, Jeeyeon Lee, Heung Kyu Park, Woosung Lim, Woo, Joohyun, Oh, Se Jeong, Song, Jeong-Yoon, Chae, Byung Joo, Choi, Jung Eun, Lee, Jeeyeon, Park, Heung Kyu, Korean Breast Cancer Society, and Lim, Woosung

Abstract

Background: In estrogen receptor (ER)-positive breast cancer (BC), young age is associated with poor prognosis. While very young patients respond better to chemotherapy, chemotherapy is less effective in ER-positive tumors than in ER-negative tumors. The authors tried to evaluate chemotherapy response of very young patients with ER-positive BC by pathologic complete response (pCR) after neoadjuvant chemotherapy excluding the effect of endocrine treatment to the extent possible.Methods: We collected individual patient data from 1992 to 2013 from the Korean Breast Cancer Society (KBCS). Total 1048 ER-positive and 797 ER-negative patients aged < 50 years who had been treated with neoadjuvant chemotherapy were included for analysis. We compared pCR rate between patients aged < 35 years with ER-positive tumors and the other groups.Results: The proportion of patients aged < 35 years was 14.0% of patients with ER-positive BC in this cohort of under 50 years old, and 16.8% of patients with ER-negative BC in this cohort of under 50 years old. Although most characteristics of tumors according to age were comparable, tumors with high Ki-67 expression were more common in patients aged < 35 years than in patients aged 35-49 years in both ER-positive and -negative group (P = 0.001). Breast conservation rates were not significantly different according to age (44.2% vs. 46.8% in ER-positive group, 55.2% vs. 48.0% in ER-negative group). pCR rate was not different according to age in ER-positive group (P = 0.71) but significantly better in patients aged < 35 years in ER-negative group (P = 0.009). After adjusting for confounding variables, young patients maintained the higher probability of pCR than older patients in ER-negative tumors. However, pCR rate did not differ according to age in ER-positive tumors. In multivariate analysis, young age (< 35 years) was correlated with poor overall survival (P = 0.003, HR = 1.98) and there was only one event in a few patients achieved pCR in ER-positive group.Conclusions: Chemotherapy response based on pCR was not better in young patients (< 35 years) with ER-positive BC than in older premenopausal patients with non-metastatic ER-positive BC. Young age cannot be a predictive factor of response to neoadjuvant chemotherapy in ER-positive BC. Different biological characteristics such as high proliferative index should be considered.Trial Registration: Retrospectively registered. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Poor Prognosis of Lower Inner Quadrant in Lymph Node–negative Breast Cancer Patients Who Received No Chemotherapy: A Study Based on Nationwide Korean Breast Cancer Registry Database

Author

Hwang, Ki-Tae, primary, Kim, Jongjin, additional, Kim, Eun-Kyu, additional, Jung, Sung Hoo, additional, Sohn, Guiyun, additional, Kim, Seung Il, additional, Jeong, Joon, additional, Lee, Hyouk Jin, additional, Park, Jin Hyun, additional, Oh, Sohee, additional, Ahn, Sei Hyun, additional, Noh, Dong-Young, additional, Nam, Seok Jin, additional, Lee, Eun Sook, additional, Park, Byeong-Woo, additional, Noh, Woo Chul, additional, Yoon, Jung Han, additional, Lee, Soo Jung, additional, Lee, Eun Kyu, additional, Han, Sehwan, additional, Park, Ho Yong, additional, Paik, Nam-Sun, additional, Bae, Young Tae, additional, Park, Heung Kyu, additional, Ko, Seung Sang, additional, Song, Byung Joo, additional, Suh, Young Jin, additional, Cho, Se Heon, additional, Kim, Sei Joong, additional, Oh, Se Jeong, additional, Ko, Byung Kyun, additional, Kim, Ku Sang, additional, Park, Chanheun, additional, Baek, Jong-Min, additional, Hwang, Ki-Tae, additional, Chang, Il-Sung, additional, Bae, Jeoung Won, additional, Kim, Jeong-Soo, additional, Kang, Sun Hee, additional, Gwak, Geumhee, additional, Lee, Jee Hyun, additional, Kim, Tae Hyun, additional, Chang, Myungchul, additional, Kim, Sung Yong, additional, Lee, Jung Sun, additional, Song, Jeong-Yoon, additional, Park, Hai Lin, additional, Min, Sun Young, additional, Yang, Jung-Hyun, additional, Park, Sung Hwan, additional, Park, Woo-Chan, additional, Kim, Lee Su, additional, Ryu, Dong Won, additional, Kim, Kweon Cheon, additional, Chung, Min Sung, additional, Park, Hee Boong, additional, Lim, Cheol Wan, additional, Choi, Un Jong, additional, Kwak, Beom Seok, additional, Park, Young Sam, additional, Shin, Hyuk Jai, additional, Choi, Young Jin, additional, Kim, Doyil, additional, Han, Airi, additional, Koh, Jong Hyun, additional, Choi, Sangyong, additional, Yoon, Daesung, additional, Choi, Soo Youn, additional, Chul, Shin Hee, additional, Kim, Jae Il, additional, Choi, Jae Hyuck, additional, Ryu, Jin Woo, additional, Ko, Chang Dae, additional, Lee, Il Kyun, additional, Lee, Dong Seok, additional, Choi, Seunghye, additional, Min, Youn Ki, additional, Jeon, Young San, additional, and Park, Eun-Hwa, additional

Published
2017
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