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8. New constituents from the Korean sponge Plakortis simplex.

Author

Oh JS, Hwang BS, Kang OH, Kwon DY, and Rho JR

Subjects
Alkaloids chemistry, Animals, Antifungal Agents chemistry, Antifungal Agents pharmacokinetics, Candida albicans drug effects, Cells, Cultured, Mice, Peroxides chemistry, Peroxides pharmacology, Plakortis chemistry, Porifera chemistry
Abstract

Six new cyclic peroxides (1-6) were isolated from the Korean sponge Plakortis simplex, along with two new alkylpyridinium alkaloids (7 and 8). The structures of these compounds were completely determined by a combination of NMR analysis and chemical reactions. Compounds 1-6 exhibited cytotoxic/antifungal activities against RAW264.7 cells and Candida albicans.

Published
2013
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