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4. Computed Tomography Aortic Valve Calcium Scoring in Patients With Bicuspid Aortic Valve Stenosis

Author

Shen, Mylène, Oh, Jin Kyung, Guzzetti, Ezequiel, Singh, Gurpreet K., Pawade, Tania, Tastet, Lionel, Clavel, Marie-Annick, Delgado, Victoria, Bax, Jeroen J., Dweck, Marc R., Abbas, Amr E., Mando, Ramy, Falconi, Mariano Luis, Perez de Arenaza, Diego, Poh, Kian Keong, Kong, William, Tay, Edgar, Pressman, Gregg, Brito, Daniel, Song, Jae Kwan, and Pibarot, Philippe

Published
2022
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8. Effect of race on pressure recovery adjustment for prevention of aortic stenosis grading discordance

Author

Oh, Jin Kyung, primary, Shen, Mylène, additional, Guzzetti, Ezequiel, additional, Tastet, Lionel, additional, Loganath, Krithika, additional, Botezatu, Simona, additional, Lee, Seung-Ah, additional, Lee, Sahmin, additional, Kim, Dae-Hee, additional, Song, Jong-Min, additional, Kang, Duk-Hyun, additional, Dweck, Marc R, additional, Pibarot, Philippe, additional, Clavel, Marie-Annick, additional, and Song, Jae-Kwan, additional

Published
2023
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9. Association between Proinflammatory Cytokines and Lung Cancer Risk: A Case-Cohort Study from a Community-Based Prospective Cohort.

Author

Park, Eun Young, Park, Eunjung, Jin, Taiyue, Lim, Min Kyung, and Oh, Jin-Kyung

Subjects
CYTOKINES, ADENOCARCINOMA, INTERLEUKINS, HUMAN research subjects, CONFIDENCE intervals, LUNG tumors, REGRESSION analysis, RISK assessment, INFORMED consent (Medical law), ENZYME-linked immunosorbent assay, TUMOR necrosis factors, DESCRIPTIVE statistics, RESEARCH funding, TUMOR markers, DATA analysis software, LONGITUDINAL method, PROPORTIONAL hazards models, DISEASE risk factors
Abstract

Simple Summary: Recent studies have shed light on alterations in the proinflammatory tumor microenvironment as a significant carcinogenic mechanism. We carried out a case-cohort study to investigate associations between proinflammatory cytokines and lung cancer risk, considering histological types in the Korean general population (lung cancer cases: 136, subcohort: 822). Serum levels of proinflammatory cytokines (i.e., IL-6, TNF-α, IL-1β, IFN-γ, and IL-10) were measured using Quantikine® ELISA. A Cox proportional-hazards regression analysis was conducted. Serum levels of IL-6, IL-1β, and IFN-γ were associated with lung cancer risk. IL-6 was associated with lung cancer risk, regardless of the histological type. IL-1β and IFN-γ had associations with adenocarcinoma and squamous-cell carcinoma, respectively. This study, targeting an Asian population, adds causality to association between proinflammatory cytokines and lung cancer risk by replicating previous findings. Furthermore, it suggests that specific cytokines, depending on the histological type of lung cancer, may serve as potential biomarkers. Recent studies have shed light on alterations to the proinflammatory tumor microenvironment as a significant carcinogenic mechanism. Despite previous studies on associations between proinflammatory cytokines and lung cancer risk, few studies have been conducted in Asian populations. This study aimed to investigate associations between proinflammatory cytokines and lung cancer risk, considering histological types, in the Korean general population. We carried out a case-cohort study on the Korean National Cancer Center Community (KNCCC) cohort (lung cancer cases: 136, subcohort: 822). Pre-diagnostic serum levels of proinflammatory cytokines (i.e., IL-6, TNF-α, IL-1β, IFN-γ, and IL-10) were measured using Quantikine® ELISA. A Cox proportional-hazards regression analysis was conducted. In this study, serum levels of IL-6, IL-1β, and IFN-γ were associated with lung cancer risk. IL-6 was associated with lung cancer, regardless of the histological type. IL-1β had an association only with adenocarcinoma, while IFN-γ had an association only with squamous-cell carcinoma. This study shows associations between serum levels of IL-6, IL-1β, and IFN-γ and lung cancer risk, underscoring the potential of these cytokines to act as risk biomarkers. The utilization of these biomarkers for risk prediction may hold the promise of facilitating the identification of the high-risk population. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Incremental Prognostic Value of Left Ventricular Global Longitudinal Strain in Patients with Preserved Ejection Fraction Undergoing Transcatheter Aortic Valve Implantation

Author

Lee, Sun-Hack, primary, Oh, Jin Kyung, additional, Lee, Seung-Ah, additional, Kang, Do-Yoon, additional, Lee, Sahmin, additional, Kim, Ho Jin, additional, Ahn, Jung-Min, additional, Kim, Joon Bum, additional, Park, Duk-Woo, additional, Song, Jong-Min, additional, Choo, Suk Jung, additional, Kang, Duk-Hyun, additional, Song, Jae-Kwan, additional, Park, Seung-Jung, additional, Choi, Jung Hyun, additional, and Kim, Dae-Hee, additional

Published
2022
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17. Validation of aortic valve calcium quantification thresholds measured by computed tomography in Asian patients with calcific aortic stenosis

Author

Guzzetti, Ezequiel, primary, Oh, Jin Kyung, additional, Shen, Mylène, additional, Dweck, Marc R, additional, Poh, Kian Keong, additional, Abbas, Amr E, additional, Mando, Ramy, additional, Pressman, Gregg S, additional, Brito, Daniel, additional, Tastet, Lionel, additional, Pawade, Tania, additional, Falconi, Mariano Luis, additional, de Arenaza, Diego Perez, additional, Kong, William, additional, Tay, Edgar, additional, Pibarot, Philippe, additional, Song, Jae-Kwan, additional, and Clavel, Marie-Annick, additional

Published
2021
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18. Prognostic impact of left ventricular mass regression after transcatheter aortic valve replacement in patients with left ventricular hypertrophy

Author

Oh, Jin Kyung, primary, Lee, Sun Hack, additional, Lee, Seung-Ah, additional, Kang, Do-Yoon, additional, Lee, Sahmin, additional, Kim, Ho Jin, additional, Ahn, Jung-Min, additional, Kim, Joon Bum, additional, Park, Duk-Woo, additional, Song, Jong-Min, additional, Choo, Suk Jung, additional, Kang, Duk-Hyun, additional, Song, Jae-Kwan, additional, Park, Seung-Jung, additional, and Kim, Dae-Hee, additional

Published
2021
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19. Validation of aortic valve calcium quantification thresholds measured by computed tomography in Asian patients with calcific aortic stenosis.

Author

Guzzetti, Ezequiel, Oh, Jin Kyung, Shen, Mylène, Dweck, Marc R, Poh, Kian Keong, Abbas, Amr E, Mando, Ramy, Pressman, Gregg S, Brito, Daniel, Tastet, Lionel, Pawade, Tania, Falconi, Mariano Luis, Arenaza, Diego Perez de, Kong, William, Tay, Edgar, Pibarot, Philippe, Song, Jae-Kwan, and Clavel, Marie-Annick

Subjects
REFERENCE values, AORTIC stenosis, CALCINOSIS, DESCRIPTIVE statistics, COMPUTED tomography, HEMODYNAMICS, ETHNIC groups, AORTIC valve
Abstract

Aims Sex-specific thresholds of aortic valve calcification (AVC) have been proposed and validated in Caucasians. Thus, we aimed to validate their accuracy in Asians. Methods and results Patients with calcific aortic stenosis (AS) from seven international centres were included. Exclusion criteria were ≥moderate aortic/mitral regurgitation and bicuspid valve. Optimal AVC and AVC-density sex-specific thresholds for severe AS were obtained in concordant grading and normal flow patients (CG/NF). We included 1263 patients [728 (57%) Asians, 573 (45%) women, 837 (66%) with CG/NF]. Mean gradient was 48 (26–64) mmHg and peak aortic velocity 4.5 (3.4–5.1) m/s. Optimal AVC thresholds were: 2145 Agatston Units (AU) in men and 1301 AU in women for Asians; and 1885 AU in men and 1129 AU in women for Caucasians. Overall, accuracy (% correctly classified) was high and comparable either using optimal or guidelines' thresholds (2000 AU in men, 1200 AU in women). However, accuracy was lower in Asian women vs. Caucasian women (76–78% vs. 94–95%; P  < 0.001). Accuracy of AVC-density (476 AU/cm2 in men and 292 AU/cm2 in women) was comparable to absolute AVC in Caucasians (91% vs. 91%, respectively, P  = 0.74), but higher than absolute AVC in Asians (87% vs. 81%, P  < 0.001). There was no interaction between AVC/AVC-density and ethnicity (all P  > 0.41) with regards to AS haemodynamic severity. Conclusion AVC thresholds defining severe AS are comparable in Asian and Caucasian populations, and similar to those proposed in the guidelines. However, accuracy of AVC to identify severe AS in Asians (especially women) is sub-optimal. Therefore, the use of AVC-density is preferable in Asians. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Determinants of clinical outcomes of surgery for isolated severe tricuspid regurgitation

Author

Park, Sung Jun, primary, Oh, Jin Kyung, additional, Kim, Seon-Ok, additional, Lee, Seung-Ah, additional, Kim, Ho Jin, additional, Lee, Sahmin, additional, Jung, Sung Ho, additional, Song, Jong-Min, additional, Choo, Suk Jung, additional, Kang, Duk-Hyun, additional, Chung, Cheol Hyun, additional, Song, Jae-Kwan, additional, Lee, Jae Won, additional, Kim, Dae-Hee, additional, and Kim, Joon Bum, additional

Published
2020
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27. ETHNIC DIFFERENCES IN COMPUTED TOMOGRAPHY AORTIC VALVE CALCIUM QUANTIFICATION IN PATIENTS WITH AORTIC STENOSIS

Author

Guzzetti, Ezequiel, primary, Oh, Jin Kyung, additional, Shen, Mylène, additional, Dweck, Marc, additional, Poh, Kian Keong, additional, Abbas, Amr E., additional, Mando, Ramy, additional, Pressman, Gregg S., additional, Brito, Daniel, additional, Tastet, Lionel Lloyd, additional, Pawade, Tania, additional, Falconi, Mariano, additional, de Arenaza, Diego Perez, additional, Kong, William, additional, Tay, Edgar, additional, Pibarot, Philippe, additional, Song, Jae-Kwan, additional, and Clavel, Marie-Annick, additional

Published
2020
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31. Clinical Situations Associated with Inappropriately Large Regurgitant Volumes in the Assessment of Mitral Regurgitation Severity Using the Proximal Flow Convergence Method in Patients with Chordae Rupture

Author

Lee, Kyusup, primary, Om, Sang Yong, additional, Lee, Sun Hack, additional, Oh, Jin Kyung, additional, Park, Hong-Kyung, additional, Choi, Yoon-Sil, additional, Lee, Seung-Ah, additional, Lee, Sahmin, additional, Kim, Dae-Hee, additional, Song, Jong-Min, additional, Kang, Duk-Hyun, additional, and Song, Jae-Kwan, additional

Published
2020
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33. Prognostic Value of Pre-Procedural Thrombolysis in Myocardial Infarction Flow in ST-Segment Elevation Myocardial Infarction Patients with Primary Percutaneous Coronary Intervention

Author

Ahn Kye Taek, Oh Jin Kyung, Jeong Jin-Ok, Jin Seon Ah, Lee Jae-Hwan, Choi Si Wan, Jeong Myung Ho, Chae Shung Chull, Cho Myeong Chan, Bae Jang Ho, Seong In-Whan, Registry Other Korea Acute Myocardial Infarction, and Investigators Korean Registry of Myocardial Infarction (KorMI)

Subjects
medicine.medical_specialty, Ventricular function, business.industry, medicine.medical_treatment, Percutaneous coronary intervention, General Medicine, Thrombolysis, medicine.disease, medicine.anatomical_structure, Reperfusion therapy, Internal medicine, cardiovascular system, medicine, Cardiology, ST segment, In patient, Myocardial infarction, business, Artery
Abstract

In patients with acute myocardial infarction (MI), it would be mandatory to rapidly perform reperfusion therapy for coronary artery involved in MI. This is an essential procedure to reduce the occurrence of myocardial injury and to lower the mortality, which is also effective in protecting cardiac muscles, preserving the left ventricular functions and improving a clinical prognosis.

Published
2018

39. Long-term Survival in Korean Elderly Patients with Symptomatic Severe Aortic Stenosis Who Refused Aortic Valve Replacement

Author

Oh, Jin Kyung, primary, Park, Jae-Hyeong, additional, Hwang, Jin Kyung, additional, Lee, Chang Hoon, additional, Park, Jong Seon, additional, Park, Joong-Il, additional, Park, Hoon-Ki, additional, Cho, Jung Sun, additional, Seo, Bong-suk, additional, Seong, Seok-Woo, additional, Sun, Byung Joo, additional, Lee, Jae-Hwan, additional, and Seong, In-Whan, additional

Published
2019
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42. Left Ventricular Longitudinal Strain and Strain Rate Values According to Sex and Classifications of Sports in the Young University Athletes Who Participated in the 2015 Gwangju Summer Universiade

Author

Park, Jae-Hyeong, primary, Oh, Jin Kyung, additional, Kim, Kye Hun, additional, Cho, Jae Yeong, additional, Cho, Goo-Yeong, additional, Lee, Jae-Hwan, additional, Seong, In-Whan, additional, Rink, Lawrence, additional, Hornsby, Kyle, additional, Jeong, Myung Ho, additional, Cho, Jeong Gwan, additional, and Park, Jong Chun, additional

Published
2018
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43. Determinants of clinical outcomes of surgery for isolated severe tricuspid regurgitation.

Author

Sung Jun Park, Jin Kyung Oh, Seon-Ok Kim, Seung-Ah Lee, Ho Jin Kim, Sahmin Lee, Sung Ho Jung, Jong-Min Song, Suk Jung Choo, Duk-Hyun Kang, Cheol Hyun Chung, Jae-Kwan Song, Jae Won Lee, Dae-Hee Kim, Joon Bum Kim, Park, Sung Jun, Oh, Jin Kyung, Kim, Seon-Ok, Lee, Seung-Ah, and Kim, Ho Jin

Subjects
TRICUSPID valve surgery, TREATMENT effectiveness, MARKOV chain Monte Carlo, HEART valve diseases, HEART transplantation, BLOOD pressure, HEMOGLOBINS, AGE distribution, RETROSPECTIVE studies, PROGNOSIS, SEVERITY of illness index, HEART atrium, PROSTHETIC heart valves, LONGITUDINAL method, BILIRUBIN
Abstract

Objectives: Although the incidence of patients with isolated tricuspid regurgitation (TR) is increasing, data regarding the clinical outcomes of isolated TR surgery are limited. This study sought to investigate the prognostic implications according to procedural types, and to identify preoperative predictors of clinical outcomes after isolated TR surgery.Methods: Among consecutive 2610 patients receiving tricuspid valve (TV) procedure, we analysed 238 patients (age, 59.6 years; 143 females) who underwent stand-alone TV surgery (repair, 132; replacement, 106) for severe TR. Primary outcome was the composite of all-cause mortality and heart transplantation. Clinical outcomes between the repair and the replacement groups were compared after adjusting with the inverse probability of treatment weighting (IPTW) method.Results: During follow-up (median, 4.1 years), 53 patients died and 4 received heart transplantation. Multivariable analysis revealed that age (p=0.001), haemoglobin level (p=0.003), total bilirubin (p=0.040), TR jet area (p=0.005) and right atrial (RA) pressure (p=0.022) were independent predictors of the primary outcome. After IPTW adjustment, there were no significant intergroup differences in the risk of primary outcome (HR 1.01; 95% CI 0.55 to 1.87). In the subgroup analysis, tricuspid annular diameter was identified as a significant effect modifier (p=0.012) in the comparison between repair versus replacement, showing a trend favouring replacement in patients with annular diameter >44 mm.Conclusions: The outcomes of stand-alone severe TR surgery were independently associated with the severity of TR and RA pressure. In selected patients with severe annular dilation >44 mm, replacement may become a feasible option. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Transcranial Doppler as a Screening Tool for High‐Risk Patent Foramen Ovale in Cryptogenic Stroke.

Author

Park, Seongho, Oh, Jin Kyung, Song, Jae‐Kwan, Kwon, Boseong, Kim, Bum Joon, Kim, Jong S., Kang, Dong‐Wha, Chang, Jun Young, Lee, Ji Sung, and Kwon, Sun U.

Subjects
*TRANSESOPHAGEAL echocardiography, *CEREBROSPINAL fluid shunts, *RECEIVER operating characteristic curves, *PATENT foramen ovale
Abstract

BACKGROUND AND PURPOSE: The identification of high‐risk patent foramen ovale (PFO) is important for selecting suitable patients for PFO closure to prevent recurrent stroke in those with cryptogenic stroke. We aimed to evaluate the predictability of transcranial Doppler (TCD) in diagnosing high‐risk PFO compared with that of transesophageal echocardiography (TEE), which is not feasible for some stroke patients. METHODS: We retrospectively reviewed the data of 461 cryptogenic stroke patients who underwent TEE and TCD for PFO evaluation. High‐risk PFO on TEE was defined as PFO with atrial septal aneurysm (phasic septal excursion ≥10 mm) or large PFO (≥2 mm). Spencer grading of right‐to‐left shunt was used to classify the amount of shunt on TCD. RESULTS: PFO on TEE was observed for 242 (52.5%) patients, and high‐risk PFO was detected for 123 (26.7%) patients. However, PFO on TCD was observed for 336 (72.9%) patients. Among patients with significant shunt (Spencer grade III or higher) who underwent TCD after Valsalva maneuver (VM), 60.0% of patients had high‐risk PFO. However, only 5.3% of patients had high‐risk PFO among those without significant shunt. Receiver operating characteristic curves showed that significant shunt after VM had higher predictability (AUC =.876, 95% CI:.843‐.905) for detecting the high‐risk PFO compared with the predictability based on significant shunt at rest (AUC =.718, 95% CI:.674‐.759). (P<.0001 for the differences between two AUCs). CONCLUSIONS: TCD is a good screening tool for evaluating high‐risk PFO. VM is important for the evaluation of PFO. Patients with minimal or no shunt on TCD after VM are unlikely to have high‐risk PFO. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Socioeconomic Inequalities in Stomach Cancer Screening in Korea, 2005–2015: After the Introduction of the National Cancer Screening Program

Author

Lee, Eun-young, primary, Lee, Yoon Young, additional, Suh, Mina, additional, Choi, Eunji, additional, Mai, Tran Thi Xuan, additional, Cho, Hyunsoon, additional, Park, Boyoung, additional, Jun, Jae Kwan, additional, Kim, Yeol, additional, Oh, Jin Kyung, additional, Ki, Moran, additional, and Choi, Kui Son, additional

Published
2018
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49. Determinants of clinical outcomes of surgery for isolated severe tricuspid regurgitation

Author

Park, Sung Jun, Oh, Jin Kyung, Kim, Seon-Ok, Lee, Seung-Ah, Kim, Ho Jin, Lee, Sahmin, Jung, Sung Ho, Song, Jong-Min, Choo, Suk Jung, Kang, Duk-Hyun, Chung, Cheol Hyun, Song, Jae-Kwan, Lee, Jae Won, Kim, Dae-Hee, and Kim, Joon Bum

Abstract

ObjectivesAlthough the incidence of patients with isolated tricuspid regurgitation (TR) is increasing, data regarding the clinical outcomes of isolated TR surgery are limited. This study sought to investigate the prognostic implications according to procedural types, and to identify preoperative predictors of clinical outcomes after isolated TR surgery.MethodsAmong consecutive 2610 patients receiving tricuspid valve (TV) procedure, we analysed 238 patients (age, 59.6 years; 143 females) who underwent stand-alone TV surgery (repair, 132; replacement, 106) for severe TR. Primary outcome was the composite of all-cause mortality and heart transplantation. Clinical outcomes between the repair and the replacement groups were compared after adjusting with the inverse probability of treatment weighting (IPTW) method.ResultsDuring follow-up (median, 4.1 years), 53 patients died and 4 received heart transplantation. Multivariable analysis revealed that age (p=0.001), haemoglobin level (p=0.003), total bilirubin (p=0.040), TR jet area (p=0.005) and right atrial (RA) pressure (p=0.022) were independent predictors of the primary outcome. After IPTW adjustment, there were no significant intergroup differences in the risk of primary outcome (HR 1.01; 95% CI 0.55 to 1.87). In the subgroup analysis, tricuspid annular diameter was identified as a significant effect modifier (p=0.012) in the comparison between repair versus replacement, showing a trend favouring replacement in patients with annular diameter >44 mm.ConclusionsThe outcomes of stand-alone severe TR surgery were independently associated with the severity of TR and RA pressure. In selected patients with severe annular dilation >44 mm, replacement may become a feasible option.

Published
2021
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