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319 results on '"Oh, Jennifer M."'

1. Age-related differences in white matter microstructure measured by advanced diffusion MRI in healthy older adults at risk for Alzheimer’s disease

Author

Motovylyak, Alice, Vogt, Nicholas M., Adluru, Nagesh, Ma, Yue, Wang, Rui, Oh, Jennifer M., Kecskemeti, Steven R., Alexander, Andrew L., Dean, Douglas C., Gallagher, Catherine L., Sager, Mark A., Hermann, Bruce P., Rowley, Howard A., Johnson, Sterling C., Asthana, Sanjay, Bendlin, Barbara B., and Okonkwo, Ozioma C.

Published
2022
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3. Alzheimer's disease biomarker burden in primary motor cortices is associated with poorer dexterity performance.

Author

Gupta, Lily, Ma, Yue, Kohli, Akshay, Yang, Kao Lee, Oh, Jennifer M., Betthauser, Tobey J., Chin, Nathaniel A., Okonkwo, Ozioma C., Pasquesi, Mary‐Elizabeth, Nair, Veena, Prabhakaran, Vivek, Li, Shi‐Jiang, and Bendlin, Barbara

Abstract

INTRODUCTION: Motor function has correlated with longevity and functionality; however, there is limited research on those with Alzheimer's disease (AD). We studied the association between motor functionality and AD pathology in primary motor and medial temporal cortices. METHODS: A total of 206 participants with a clinical diagnosis of cognitively healthy, AD, or mild cognitive impairment (MCI) underwent imaging and motor assessment. Linear regressions and analyses of variance were applied to test the prediction from AD imaging biomarkers to motor performance and the diagnosis group differences in motor performance. RESULTS: Increased neurodegeneration was associated with worsening dexterity and lower walking speed, and increased amyloid and tau were associated with worsening dexterity. AD and MCI participants had lower motor performance than the cognitively healthy participants. DISCUSSION: Increased AD pathology is associated with worsening dexterity performance. The decline in dexterity in those with AD pathology may offer an opportunity for non‐pharmacological therapy intervention. Highlights: Noted worsening dexterity performance was associated with greater Alzheimer's disease (AD) pathology (tau, amyloid beta, and neurodegeneration) in primary motor cortices.Similarly, increased neurodegeneration and tau pathology in parahippocampal, hippocampal, and entorhinal cortices is associated with worsening dexterity performance.Motor performance declined in those with clinical and preclinical AD among an array of motor assessments. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Relationship between APOE risk score and myelin in Alzheimer’s disease

Author

Schulz, Nicholas R, primary, Yang, Kao Lee, additional, Oh, Jennifer M., additional, Kang, Theresa J, additional, Randall, Allison M, additional, Davenport‐Sis, Nancy J, additional, Deming, Yuetiva, additional, Van Hulle, Carol A., additional, Betthauser, Tobey J, additional, Dean, Doug C, additional, Johnson, Sterling C, additional, Alexander, Andrew L, additional, and Bendlin, Barbara B, additional

Published
2023
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6. KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD

Author

Erickson, Claire M., Schultz, Stephanie A., Oh, Jennifer M., Darst, Burcu F., Ma, Yue, Norton, Derek, Betthauser, Tobey, Gallagher, Catherine L., Carlsson, Cynthia M., Bendlin, Barbara B., Asthana, Sanjay, Hermann, Bruce P., Sager, Mark A., Blennow, Kaj, Zetterberg, Henrik, Engelman, Corinne D., Christian, Bradley T., Johnson, Sterling C., Dubal, Dena B., and Okonkwo, Ozioma C.

Published
2019
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8. Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation

Author

Racine, Annie M., Koscik, Rebecca L., Nicholas, Christopher R., Clark, Lindsay R., Okonkwo, Ozioma C., Oh, Jennifer M., Hillmer, Ansel T., Murali, Dhanabalan, Barnhart, Todd E., Betthauser, Tobey J., Gallagher, Catherine L., Rowley, Howard A., Dowling, N. Maritza, Asthana, Sanjay, Bendlin, Barbara B., Blennow, Kaj, Zetterberg, Henrik, Carlsson, Cynthia M., Christian, Bradley T., and Johnson, Sterling C.

Published
2016
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9. Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer's Prevention

Author

Doherty, Benjamin M., Schultz, Stephanie A., Oh, Jennifer M., Koscik, Rebecca L., Dowling, N. Maritza, Barnhart, Todd E., Murali, Dhanabalan, Gallagher, Catherine L., Carlsson, Cynthia M., Bendlin, Barbara B., LaRue, Asenath, Hermann, Bruce P., Rowley, Howard A., Asthana, Sanjay, Sager, Mark A., Christian, Brad T., Johnson, Sterling C., and Okonkwo, Ozioma C.

Published
2015
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12. Higher cortical myelin is associated with worse performance on cognitive tests: Findings from the Alzheimer’s Disease Connectome Project

Author

Kohli, Akshay, primary, Kecskemeti, Steven R, additional, Yang, Kao Lee, additional, Oh, Jennifer M., additional, Nair, Veena A., additional, Pasquesi, Mary‐Elizabeth, additional, Okonkwo, Ozioma C., additional, Alexander, Andrew L, additional, Prabhakaran, Vivek, additional, Li, Shi‐Jiang, additional, and Bendlin, Barbara B., additional

Published
2022
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13. Brain insulin signaling and neurodegeneration: IRS‐1 isolated from neuronal enriched extracellular vesicles associates with frontal lobe gray matter volume in cognitively unimpaired adults

Author

Peter, Darby, primary, Ennis, Gilda E., additional, Eren, Erden, additional, III, Doug C Dean, additional, Oh, Jennifer M., additional, Asthana, Sanjay, additional, Johnson, Sterling C., additional, Kapogiannis, Dimitrios, additional, and Bendlin, Barbara B., additional

Published
2022
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14. Amyloid burden and neural function in people at risk for Alzheimer's Disease

Author

Johnson, Sterling C., Christian, Bradley T., Okonkwo, Ozioma C., Oh, Jennifer M., Harding, Sandra, Xu, Guofan, Hillmer, Ansel T., Wooten, Dustin W., Murali, Dhanabalan, Barnhart, Todd E., Hall, Lance T., Racine, Annie M., Klunk, William E., Mathis, Chester A., Bendlin, Barbara B., Gallagher, Catherine L., Carlsson, Cynthia M., Rowley, Howard A., Hermann, Bruce P., Dowling, N. Maritza, Asthana, Sanjay, and Sager, Mark A.

Published
2014
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18. Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer’s disease

Author

Boots, Elizabeth A., Schultz, Stephanie A., Oh, Jennifer M., Larson, Jordan, Edwards, Dorothy, Cook, Dane, Koscik, Rebecca L., Dowling, Maritza N., Gallagher, Catherine L., Carlsson, Cynthia M., Rowley, Howard A., Bendlin, Barbara B., LaRue, Asenath, Asthana, Sanjay, Hermann, Bruce P., Sager, Mark A., Johnson, Sterling C., and Okonkwo, Ozioma C.

Published
2015
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19. Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease

Author

Vesperman, Clayton J., primary, Wang, Rui, additional, Schultz, Stephanie A., additional, Law, Lena L., additional, Dougherty, Ryan J., additional, Ma, Yue, additional, Oh, Jennifer M., additional, Edwards, Dorothy F., additional, Gallagher, Catherine L., additional, Chin, Nathaniel A., additional, Asthana, Sanjay, additional, Hermann, Bruce P., additional, Sager, Mark A., additional, Johnson, Sterling C., additional, Cook, Dane B., additional, and Okonkwo, Ozioma C., additional

Published
2022
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20. Exercise and carbohydrate‐restricted diet associates with improved cerebral blood flow

Author

Heston, Margo B., primary, Gaitán, Julian M., additional, Ma, Yue, additional, Oh, Jennifer M., additional, Jen, Mu‐lan, additional, Derynda, Brittany R, additional, Lose, Sarah, additional, Kozuch, Michael P., additional, Johnson, Kevin M., additional, Okonkwo, Ozioma C., additional, Gretebeck, Kimberlee A., additional, Gretebeck, Randall J., additional, and Bendlin, Barbara B., additional

Published
2021
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22. Impact of sex andAPOEε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study

Author

Wang, Rui, primary, Oh, Jennifer M, additional, Motovylyak, Alice, additional, Ma, Yue, additional, Sager, Mark A, additional, Rowley, Howard A, additional, Johnson, Kevin M, additional, Gallagher, Catherine L, additional, Carlsson, Cynthia M, additional, Bendlin, Barbara B, additional, Johnson, Sterling C, additional, Asthana, Sanjay, additional, Eisenmenger, Laura, additional, and Okonkwo, Ozioma C, additional

Published
2021
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23. sj-pdf-1-jcb-10.1177_0271678X211021313 - Supplemental material for Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study

Author

Wang, Rui, Oh, Jennifer M, Motovylyak, Alice, Ma, Yue, Sager, Mark A, Rowley, Howard A, Johnson, Kevin M, Gallagher, Catherine L, Carlsson, Cynthia M, Bendlin, Barbara B, Johnson, Sterling C, Asthana, Sanjay, Eisenmenger, Laura, and Okonkwo, Ozioma C

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211021313 for Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study by Rui Wang, Jennifer M Oh, Alice Motovylyak, Yue Ma, Mark A Sager, Howard A Rowley, Kevin M Johnson, Catherine L Gallagher, Cynthia M Carlsson, Barbara B Bendlin, Sterling C Johnson, Sanjay Asthana, Laura Eisenmenger and Ozioma C Okonkwo in Journal of Cerebral Blood Flow & Metabolism

Published
2021
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24. Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults : A longitudinal study.

Author

Wang, Rui, Oh, Jennifer M, Motovylyak, Alice, Ma, Yue, Sager, Mark A, Rowley, Howard A, Johnson, Kevin M, Gallagher, Catherine L, Carlsson, Cynthia M, Bendlin, Barbara B, Johnson, Sterling C, Asthana, Sanjay, Eisenmenger, Laura, Okonkwo, Ozioma C, Wang, Rui, Oh, Jennifer M, Motovylyak, Alice, Ma, Yue, Sager, Mark A, Rowley, Howard A, Johnson, Kevin M, Gallagher, Catherine L, Carlsson, Cynthia M, Bendlin, Barbara B, Johnson, Sterling C, Asthana, Sanjay, Eisenmenger, Laura, and Okonkwo, Ozioma C

Abstract

Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer's disease, but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well-studied. This longitudinal study is consisted of 950 participants (40-89 years), who were cognitively unimpaired at their first visit. We investigated the age-related changes in cerebral perfusion, and their associations with APOE-genotype, biological sex, and cardiometabolic measurements. During the follow-up period (range 0.13-8.24 years), increasing age was significantly associated with decreasing cerebral perfusion, in total gray-matter (β=-1.43), hippocampus (-1.25), superior frontal gyrus (-1.70), middle frontal gyrus (-1.99), posterior cingulate (-2.46), and precuneus (-2.14), with all P-values < 0.01. Compared with male-ɛ4 carriers, female-ɛ4 carriers showed a faster decline in global and regional cerebral perfusion with increasing age, whereas the age-related decline in cerebral perfusion was similar between male- and female-ɛ4 non-carriers. Worse cardiometabolic profile (i.e., increased blood pressure, body mass index, total cholesterol, and blood glucose) was associated with lower cerebral perfusion at all the visits. When time-varying cardiometabolic measurements were adjusted in the model, the synergistic effect of sex and APOE-ɛ4 on age-related cerebral perfusion-trajectories became largely attenuated. Our findings demonstrate that APOE-genotype and sex interactively impact cerebral perfusion-trajectories in mid- to late-life. This effect may be partially explained by cardiometabolic alterations.

Published
2021
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26. Alzheimer’s pathologic change indexed by CSF B‐amyloid42 associates with longitudinal alterations in myelin content

Author

Yang, Kao Lee, primary, Dean, Douglas C, additional, Oh, Jennifer M, additional, Koscik, Rebecca L, additional, Ma, Yue, additional, Kohli, Akshay, additional, Chin, Nathaniel A, additional, Carlsson, Cynthia M, additional, Johnson, Sterling C, additional, Asthana, Sanjay, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Alexander, Andrew L, additional, and Bendlin, Barbara B, additional

Published
2020
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27. Impact of sex and APOE E4 on age‐related cerebral blood flow trajectories in cognitively asymptomatic middle‐aged and older adults: A longitudinal study

Author

Wang, Rui, primary, Oh, Jennifer M., additional, Motovylyak, Alice, additional, Ma, Yue, additional, Sager, Mark A., additional, Rowley, Howard A., additional, Johnson, Kevin M., additional, Gallagher, Catherine L., additional, Carlsson, Cynthia M., additional, Bendlin, Barbara B, additional, Johnson, Sterling C., additional, Asthana, Sanjay, additional, Eisenmenger, Laura, additional, and Okonkwo, Ozioma C., additional

Published
2020
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31. IC-P-081: CSF MARKERS OF NEURODEGENERATION ARE ASSOCIATED WITH QUANTITATIVE T1

Author

Kohli, Akshay, primary, Lee Yang, Kao, additional, Vogt, Nicholas M., additional, Dean, Doug C., additional, Oh, Jennifer M., additional, Asthana, Sanjay, additional, Johnson, Sterling C., additional, Carlsson, Cynthia, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Alexander, Andrew L., additional, Kecskemeti, Steven, additional, and Bendlin, Barbara B., additional

Published
2019
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32. P2-399: CSF MARKERS OF NEURODEGENERATION ARE ASSOCIATED WITH QUANTITATIVE T1

Author

Kohli, Akshay, primary, Lee Yang, Kao, additional, Vogt, Nicholas M., additional, Dean, Doug C., additional, Oh, Jennifer M., additional, Asthana, Sanjay, additional, Johnson, Sterling C., additional, Carlsson, Cynthia, additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Alexander, Andrew L., additional, Kecskemeti, Steven, additional, and Bendlin, Barbara B., additional

Published
2019
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35. P4-589: COMPARISON OF CEREBROSPINAL FLUID NEUROFILAMENT LIGHT CHAIN PROTEIN AND THREE MRI-BASED MORPHOMETRIC ESTIMATES FOR DEFINING NEURODEGENERATION (N) ACROSS THE ALZHEIMER'S DISEASE CONTINUUM

Author

Allison, Samantha L., primary, Koscik, Rebecca L., additional, Jonaitis, Erin, additional, Cary, Paul, additional, Rowley, Howard A., additional, Oh, Jennifer M., additional, Chin, Nathaniel A., additional, Carlsson, Cynthia, additional, Asthana, Sanjay, additional, Bendlin, Barbara B., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, and Johnson, Sterling C., additional

Published
2019
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38. Fitness Trumps Fatness: An Examination of Cognition and Cerebral Volume

Author

Gaitán, Julian M., primary, Lose, Sarah R., additional, Dougherty, Ryan J., additional, Oh, Jennifer M., additional, Gallagher, Catherine L., additional, Carlsson, Cynthia M., additional, Rowley, Howard A., additional, Ma, Yue, additional, Asthana, Sanjay, additional, Sager, Mark A., additional, Hermann, Bruce P., additional, Johnson, Sterling C., additional, Bendlin, Barbara B., additional, Cook, Dane B., additional, and Okonkwo, Ozioma C., additional

Published
2019
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39. Cross-sectional and longitudinal associations between total and regional white matter hyperintensity volume and cognitive and motor function in Parkinson's disease

Author

Pozorski, Vincent, primary, Oh, Jennifer M., additional, Okonkwo, Ozioma, additional, Krislov, Stephanie, additional, Barzgari, Amy, additional, Theisen, Frances, additional, Sojkova, Jitka, additional, Bendlin, Barbara B., additional, Johnson, Sterling C., additional, and Gallagher, Catherine L., additional

Published
2019
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40. Family history and TOMM40 ‘523 interactive associations with memory in middle-aged and AD cohorts

Author

Willette, Auriel A., Webb, Joseph, Lutz, Michael W., Bendlin, Barbara B., Wennberg, Alexandra M, Oh, Jennifer M., Roses, Allen, Koscik, Rebecca L., Hermann, Bruce P., Dowling, N. Maritza, Asthana, Sanjay, and Johnson, Sterling C.

Subjects
Adult, Family Health, Male, Memory Disorders, Genotype, Membrane Transport Proteins, Middle Aged, Neuropsychological Tests, Polymorphism, Single Nucleotide, Article, Cohort Studies, Apolipoproteins E, Alzheimer Disease, Mitochondrial Precursor Protein Import Complex Proteins, Humans, Female, Genetic Predisposition to Disease, Mental Status Schedule, Aged
Abstract

Family history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa (TOMM40) rs10524523 ('523) poly-T length on memory decline.For 912 nonapolipoprotein ε4 middle-aged adults and 365 aged adults across the AD spectrum, linear mixed models gauged FH and TOMM40 '523 interactions on memory and global cognition between baseline and up to 10 years later. A cerebrospinal fluid mitochondrial function biomarker was also assessed.For FH negative participants, gene-dose preservation of memory and global cognition was seen for "very long" versus "short" carriers. For FH positive, an opposite gene-dose decline was seen for very long versus short carriers. Maternal FH was a stronger predictor in aged, but not middle-aged, participants. Similar gene-dose effects were seen for the mitochondrial biomarker aspartate aminotransferase.These results may clarify conflicting findings on TOMM40 poly-T length and AD-related decline.

Published
2017

41. Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease

Author

Dougherty, Ryan J., Ellingson, Laura D., Schultz, Stephanie A., Boots, Elizabeth A., Meyer, Jacob D., Lindheimer, Jacob B., Van Riper, Stephanie, Stegner, Aaron J., Edwards, Dorothy F., Oh, Jennifer M., Koscik, Rebecca L., Dowling, Maritza N., Gallagher, Catherine L., Carlsson, Cynthia M., Rowley, Howard A., Bendlin, Barbara B., Asthana, Sanjay, Hermann, Bruce P., Sager, Mark A., Johnson, Sterling C., Okonkwo, Ozioma C., and Cook, Dane B.

Published
2016
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42. O1‐03‐04: HYPOXIA DURING SLEEP IS ASSOCIATED WITH HIPPOCAMPAL VOLUME IN COGNITIVELY UNIMPAIRED ADULTS

Author

Taylor, Chase E., primary, Sprecher, Kate E., additional, Vogt, Nicholas M., additional, Derynda, Brittany R., additional, Shouel, Heather L., additional, Oh, Jennifer M., additional, Jones, Stephanie G., additional, Riedner, Brady A., additional, Bazalakova, Mihaela H., additional, Plante, David T., additional, Johnson, Sterling C., additional, Asthana, Sanjay, additional, Benca, Ruth M., additional, and Bendlin, Barbara B., additional

Published
2018
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43. P4‐324: HOW DO WE DEFINE N+? COMPARISON OF DIFFERENT MRI‐BASED MORPHOMETRIC ESTIMATES FOR DEFINING NEURODEGENERATION IN CSF AMYLOID‐POSITIVE INDIVIDUALS ACROSS THE ALZHEIMER'S DISEASE SPECTRUM

Author

Allison, Samantha L., primary, Cary, Paul, additional, Jonaitis, Erin, additional, Oh, Jennifer M., additional, Chin, Nathaniel A., additional, Rowley, Howard A., additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Carlsson, Cynthia M., additional, Asthana, Sanjay, additional, Bendlin, Barbara B., additional, and Johnson, Sterling C., additional

Published
2018
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44. P4‐375: CEREBRAL GLUCOSE UPTAKE DIFFERS BY LEVEL OF HOMA‐IR AND INSULIN SECRETION IN NONDIABETIC ADULTS

Author

Ennis, Gilda E., primary, Koscik, Rebecca L., additional, Davenport, Nancy J., additional, Taylor, Chase E., additional, Oh, Jennifer M., additional, Christian, Brad T., additional, Chin, Nathaniel A., additional, Asthana, Sanjay, additional, Johnson, Sterling C., additional, Okonkwo, Ozioma C., additional, and Bendlin, Barbara B., additional

Published
2018
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45. IC‐P‐180: QUANTITATIVE T1 IN ALZHEIMER'S DISEASE

Author

Kohli, Akshay, primary, Merluzzi, Andrew P., additional, Oh, Jennifer M., additional, Asthana, Sanjay, additional, Johnson, Sterling C., additional, Alexander, Andrew L., additional, Kecskemeti, Steven, additional, and Bendlin, Barbara B., additional

Published
2018
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47. O3‐04‐06: TAU IMAGING WITH [F‐18]MK6240 ACROSS THE AD SPECTRUM: ASSOCIATIONS WITH AMYLOID AND COGNITIVE STATUS

Author

Johnson, Sterling C., primary, Betthauser, Tobey J., additional, Clark, Lindsay R., additional, Cody, Karly Alex, additional, Zammit, Matthew D., additional, DiFilippo, Alexandra H., additional, Murali, Dhanabalan, additional, Converse, Alexander K., additional, Barnhart, Todd E., additional, Stone, Charles K., additional, Poetter, Jennifer, additional, Sanson, Leah, additional, Oh, Jennifer M., additional, Chin, Nathaniel A., additional, Carlsson, Cynthia M., additional, Asthana, Sanjay, additional, Rowley, Howard A., additional, and Christian, Brad T., additional

Published
2018
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49. P1‐471: QUANTITATIVE T1 IN ALZHEIMER'S DISEASE

Author

Kohli, Akshay, primary, Merluzzi, Andrew P., additional, Oh, Jennifer M., additional, Asthana, Sanjay, additional, Johnson, Sterling C., additional, Alexander, Andrew L., additional, Kecskemeti, Steven, additional, and Bendlin, Barbara B., additional

Published
2018
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