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43 results on '"Oh, Byoung Chol"'

8. Gluconate-Lactobionate-Dextran Perfusion Solutions Attenuate Ischemic Injury and Improve Function in a Murine Cardiac Transplant Model

Author

Guo, Yinan, primary, Messner, Franka, additional, Beck, Sarah E., additional, Iglesias Lozano, Marcos, additional, Schwelberger, Hubert, additional, Zhang, Yichuan, additional, Kammers, Kai, additional, Oh, Byoung Chol, additional, Greene, Elizabeth D., additional, Brandacher, Gerald, additional, and Brockbank, Kelvin G. M., additional

Published
2022
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11. Noninvasive evaluation of intragraft immune responses in upper extremity transplantation

Author

Messner, Franka, primary, Etra, Joanna W., additional, Shores, Jaimie T., additional, Thoburn, Christopher J., additional, Hackl, Hubert, additional, Iglesias Lozano, Marcos, additional, Fidder, Samuel A. J., additional, Guo, Yinan, additional, Kambarashvili, Ketevan, additional, Alagol, Kemal, additional, Kalsi, Richa, additional, Beck, Sarah E., additional, Cooney, Carisa, additional, Furtmüller, Georg J., additional, Krapf, Johanna, additional, Oh, Byoung Chol, additional, and Brandacher, Gerald, additional

Published
2021
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13. Multiphase Assembly of Small Molecule Microcrystalline Peptide Hydrogel Allows Immunomodulatory Combination Therapy for Long‐Term Heart Transplant Survival

Author

Majumder, Poulami, primary, Zhang, Yichuan, additional, Iglesias, Marcos, additional, Fan, Lixin, additional, Kelley, James A., additional, Andrews, Caroline, additional, Patel, Nimit, additional, Stagno, Jason R., additional, Oh, Byoung Chol, additional, Furtmüller, Georg J., additional, Lai, Christopher C., additional, Wang, Yun‐Xing, additional, Brandacher, Gerald, additional, Raimondi, Giorgio, additional, and Schneider, Joel P., additional

Published
2020
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15. Vascularized composite allotransplantation combined with costimulation blockade induces mixed chimerism and reveals intrinsic tolerogenic potential

Author

Oh, Byoung Chol, primary, Furtmüller, Georg J., additional, Fryer, Madeline L., additional, Guo, Yinan, additional, Messner, Franka, additional, Krapf, Johanna, additional, Schneeberger, Stefan, additional, Cooney, Damon S., additional, Lee, W.P. Andrew, additional, Raimondi, Giorgio, additional, and Brandacher, Gerald, additional

Published
2020
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16. A novel rat microsurgical model to study the immunological characteristics of male genital tissue in the context of penile transplantation

Author

Fidder, Samuel A. J., primary, Furtmüller, Georg J., additional, Matoso, Andres, additional, Etra, Joanna W., additional, Lombardo, Kara, additional, Chicco, Maria, additional, Oh, Byoung Chol, additional, Vasilic, Dalibor, additional, Lee, Wei P. A., additional, Redett, Richard J., additional, Cooney, Damon S., additional, and Brandacher, Gerald, additional

Published
2020
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20. Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts

Author

Li, Shen, primary, Oh, Byoung Chol, additional, Chu, Chengyan, additional, Arnold, Antje, additional, Jablonska, Anna, additional, Furtmüller, Georg J, additional, Qin, Hua-Min, additional, Boltze, Johannes, additional, Magnus, Tim, additional, Ludewig, Peter, additional, Janowski, Mirosław, additional, Brandacher, Gerald, additional, and Walczak, Piotr, additional

Published
2019
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21. Abstract QS37

Author

GUO, YINAN, primary, Messner, Franka, additional, Oh, Byoung Chol, additional, Furtmüller, Georg J., additional, Lee, W.P. Andrew, additional, Cooney, Damon S., additional, Luznik, Leo, additional, and Brandacher, Gerald, additional

Published
2019
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22. Abstract 38

Author

Grzelak, Michael J., primary, Oh, Byoung Chol, additional, Furtmüller, Georg J., additional, Iglesias, Marcos, additional, Fryer, Madeline, additional, Akre, Paul J., additional, Cooney, Damon S., additional, Lee, W.P. Andrew, additional, Raimondi, Giorgio, additional, and Brandacher, Gerald, additional

Published
2018
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23. An immunocompetent mouse model of human glioblastoma

Author

Semenkow, Samantha, primary, Li, Shen, additional, Kahlert, Ulf D., additional, Raabe, Eric H., additional, Xu, Jiadi, additional, Arnold, Antje, additional, Janowski, Miroslaw, additional, Oh, Byoung Chol, additional, Brandacher, Gerald, additional, Bulte, Jeff W.M., additional, Eberhart, Charles G., additional, and Walczak, Piotr, additional

Published
2017
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25. 2587: Vascularized composite allotransplantation combined with donor bone marrow and post transplantation high-dose cyclophosphamide (PTCy) induces immune tolerance after reconstructive transplantation

Author

Furtmuller, Georg J., primary, Oh, Byoung Chol, additional, Fryer, Madeline, additional, Dodd-o, Jeffrey, additional, Ganguly, Sudipto, additional, Raimondi, Giorgio, additional, Cooney, Damon, additional, Lee, W. P. Andrew, additional, Luznik, Leo, additional, and Brandacher, Gerald, additional

Published
2016
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27. 2589: Heterotopic rat penis transplantation: A novel microsurgical model to study distinct immunologic features of urogenital tissues in the setting of reconstructive transplantation

Author

Fidder, Samuel A. J., primary, Furtmuller, Georg J., additional, Oh, Byoung Chol, additional, Kern, Barbara, additional, Lough, Denver M., additional, Lee, W. P. Andrew, additional, Cooney, Damon S., additional, Redett, Richard J., additional, and Brandacher, Gerald, additional

Published
2016
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28. 2526: Non-invasive monitoring of allograft rejection using thermal imaging in a large animal model of vascularized composite allotransplantation

Author

Kolegraff, Keli, primary, Quan, Amy, additional, Crane, Nicole, additional, Wang, Howard, additional, Lopez, Joseph, additional, Furtmuller, Georg, additional, Alfadil, Sara, additional, Mermulla, Sara, additional, Oh, Byoung Chol, additional, Akre, Paul, additional, Alonso-Escalante, Jose C., additional, Walch, Jeffrey, additional, Shores, Jaimie, additional, Cooney, Damon, additional, Bonawitz, Steven, additional, Elster, Eric, additional, Brandacher, Gerald, additional, and Lee, W. P. Andrew, additional

Published
2016
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31. 2523: Vascularized composite allograft tolerance with transient high-dose tacrolimus across a full MHC mismatch in a large animal model

Author

Wang, Howard D., primary, Swanson, Edward W., additional, Cheng, Hsu-Tang, additional, Walch, Jeffrey, additional, Alonso-Escalante, Jose C., additional, Kolegraff, Keli, additional, Lopez, Joseph, additional, Furtmuller, Georg, additional, Oh, Byoung Chol, additional, Quan, Amy, additional, Budihardjo, Joshua, additional, AlFadil, Sara, additional, Mulla, Sara, additional, Fidder, Samuel, additional, Akre, Paul, additional, Sacks, Justin M., additional, Bonawitz, Steven C., additional, Raimondi, Giorgio, additional, Shores, Jaimie T., additional, Cooney, Damon S., additional, Lee, W. P. Andrew, additional, and Brandacher, Gerald, additional

Published
2016
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32. A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels

Author

Smith, Daniel J., primary, Brat, Gabriel A., additional, Medina, Scott H., additional, Tong, Dedi, additional, Huang, Yong, additional, Grahammer, Johanna, additional, Furtmüller, Georg J., additional, Oh, Byoung Chol, additional, Nagy-Smith, Katelyn J., additional, Walczak, Piotr, additional, Brandacher, Gerald, additional, and Schneider, Joel P., additional

Published
2015
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38. A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels

Author

Smith, Daniel J., Brat, Gabriel A., Medina, Scott H., Tong, Dedi, Huang, Yong, Grahammer, Johanna, Furtmüller, Georg J., Oh, Byoung Chol, Nagy-Smith, Katelyn J., Walczak, Piotr, Brandacher, Gerald, and Schneider, Joel P.

Abstract

Many surgeries are complicated by the need to anastomose, or reconnect, micrometre-scale vessels. Although suturing remains the gold standard for anastomosing vessels, it is difficult to place sutures correctly through collapsed lumen, making the procedure prone to failure. Here, we report a multiphase transitioning peptide hydrogel that can be injected into the lumen of vessels to facilitate suturing. The peptide, which contains a photocaged glutamic acid, forms a solid-like gel in a syringe and can be shear-thin delivered to the lumen of collapsed vessels (where it distends the vessel) and the space between two vessels (where it is used to approximate the vessel ends). Suturing is performed directly through the gel. Light is used to initiate the final gel–sol phase transition that disrupts the hydrogel network, allowing the gel to be removed and blood flow to resume. This gel adds a new tool to the armamentarium for micro- and supermicrosurgical procedures.

Published
2016
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41. Hickman Catheter Use for Long-Term Vascular Access in a Preclinical Swine Model.

Author

Girard AO, Muss TE, Loftin AH, Kalsi R, Bodine AK, Lopez CD, Furtmüller GJ, Etra JW, Izzi J, Plunkard J, Brown MG, Oh BC, and Brandacher G

Subjects
Animals, Swine, Catheters, Indwelling, Central Venous Catheters adverse effects, Catheterization, Central Venous
Abstract

Central venous catheters (CVCs) are invaluable devices in large animal research as they facilitate a wide range of medical applications, including blood monitoring and reliable intravenous fluid and drug administration. Specifically, the tunneled multi-lumen Hickman catheter (HC) is commonly used in swine models due to its lower extrication and complication rates. Despite fewer complications relative to other CVCs, HC-related morbidity presents a significant challenge, as it can significantly delay or otherwise negatively impact ongoing studies. The proper insertion and maintenance of HCs is paramount in preventing these complications, but there is no consensus on best practices. The purpose of this protocol is to comprehensively describe an approach for the insertion and maintenance of a tunneled HC in swine that mitigates HC-related complications and morbidity. The use of these techniques in >100 swine has resulted in complication-free patent lines up to 8 months and no catheter-related mortality or infection of the ventral surgical site. This protocol offers a method to optimize the lifespan of the HC and guidance for approaching issues during use.

Published
2023
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42. Efficacy of pig-to-rhesus lamellar corneal xenotransplantation.

Author

Choi HJ, Kim MK, Lee HJ, Ko JH, Jeong SH, Lee JI, Oh BC, Kang HJ, and Wee WR

Subjects
Animals, Aqueous Humor immunology, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Complement System Proteins immunology, Cornea pathology, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Fluorescent Antibody Technique, Indirect, Graft Rejection immunology, Graft Survival physiology, Immunoglobulin G blood, Immunoglobulin M blood, Macaca mulatta, Macrophages immunology, Swine, Swine, Miniature, alpha-Galactosidase immunology, Cornea immunology, Corneal Transplantation, Transplantation, Heterologous
Abstract

PURPOSE. To solve the shortage of donor corneas, a decellularizing method based on hypertonic saline treatment was introduced, and a favorable outcome was observed in pig-to-rabbit lamellar corneal transplantation. This study was an investigation of the efficacy of pig-to-nonhuman primate lamellar corneal transplantation, using both decellularized and fresh porcine corneas to assess feasibility as a substitute for human corneas. METHODS. Nine Chinese rhesus macaques underwent lamellar corneal transplantation using both decellularized (n = 5) and fresh (n = 4) porcine corneas. Clinically acceptable graft size (7.5 mm in diameter) and minimal immunosuppression based on topical and systemic corticosteroids were applied. Rejection signs, histology of porcine grafts, and serial changes in recipients' blood profile, including memory T-cell subset, anti-α-Gal and donor pig-specific antibodies, and complement were evaluated. Changes in aqueous complement concentration were also assessed at 4 weeks after transplantation. RESULTS. Of the decellularized porcine lamellar grafts, 80% remained transparent for more than 6 months, whereas half of the fresh porcine lamellar grafts developed chronic rejection. Rejected grafts showed extensive cellular infiltration, predominantly CD8(+) T lymphocytes and macrophages. Immunologic profiles of the recipients with rejected grafts showed a significant increase in the concentration of aqueous complement, an enhancement of memory T cells, and an abrupt increase in donor pig-specific antibodies. CONCLUSIONS. The findings suggested that decellularized porcine cornea could be a promising substitute for human corneal allograft. Fresh porcine cornea may be a feasible option for a substitute if combined with more potent immunosuppression or if obtained from transgenic pigs with complement-regulatory proteins.

Published
2011
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43. Effect of hyperkalemia and hemolysis caused by hyperacute rejection on cardiac function in pig to human ex vivo xenogeneic cardiac perfusion model.

Author

Kim JS, Lee HM, Oh BC, Lim HG, and Lee JR

Abstract

Background and Objectives: Hyperacute rejection (HAR) is a major obstacle to successful xenotransplantation of vascularized organs. This study was conducted to observe the effect of hemolysis of perfused human whole blood on pig heart function, and determine the major risk factors for preservation of xenoperfused cardiac function using ex-vivo pig to human xenogeneic cardiac perfusion model., Materials and Methods: Harvested pig hearts were perfused with normal human whole blood (group 1), two different types of pre-treated human whole blood (group 2: immunoglobulins were depleted by plasmapheresis, group 3: pre-treated with plasmapheresis, GAS914, cobra venom factor (CVF) and steroid), and normal porcine whole blood as control (group 4) for 3 hours., Results: Duration of heart beat was significantly prolonged in group 2 and group 3. Histological examination showed widespread HAR features but was gradually delayed in groups 2 and 3 compared to group 1. The absolute levels of serum creatine kinase-MB and Troponin I increased gradually, and was lower in group 3. Serum hemoglobin levels were rapidly increased in groups 3 and 4, compared to group 1. Extracellular potassium level increased sharply from the beginning of blood perfusion in groups 1, 2 and 3, compared to group 4., Conclusion: Pretreatment of human whole blood, including immunoglobulin depletion, CVF and steroid reduced and delayed the destruction of pig myocardium by HAR. However, the increased extracellular potassium levels in groups 1, 2 and 3 reflected that these treatments could not prohibit myocardial injury by HAR.

Published
2011
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