Search

Your search keyword '"Ogwang, Martin D"' showing total 156 results
Start Over Author "Ogwang, Martin D"
156 results on '"Ogwang, Martin D"'

2. Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa

Author

Zhou, Weiyin, Fischer, Anja, Ogwang, Martin D., Luo, Wen, Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Kinyera, Tobias, Otim, Isaac, Legason, Ismail D., Nabalende, Hadijah, Ayers, Leona W., Bhatia, Kishor, Goedert, James J., Gouveia, Mateus H., Cole, Nathan, Hicks, Belynda, Jones, Kristine, Hummel, Michael, Schlesner, Mathias, Chagaluka, George, Mutalima, Nora, Borgstein, Eric, Liomba, George N., Kamiza, Steve, Mkandawire, Nyengo, Mitambo, Collins, Molyneux, Elizabeth M., Newton, Robert, Glaser, Selina, Kretzmer, Helene, Manning, Michelle, Hutchinson, Amy, Hsing, Ann W., Tettey, Yao, Adjei, Andrew A., Chanock, Stephen J., Siebert, Reiner, Yeager, Meredith, Prokunina-Olsson, Ludmila, Machiela, Mitchell J., and Mbulaiteye, Sam M.

Published
2023
Full Text
View/download PDF

3. Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma

Author

Thomas, Nicole, Dreval, Kostiantyn, Gerhard, Daniela S., Hilton, Laura K., Abramson, Jeremy S., Ambinder, Richard F., Barta, Stefan, Bartlett, Nancy L., Bethony, Jeffrey, Bhatia, Kishor, Bowen, Jay, Bryan, Anthony C., Cesarman, Ethel, Casper, Corey, Chadburn, Amy, Cruz, Manuela, Dittmer, Dirk P., Dyer, Maureen A., Farinha, Pedro, Gastier-Foster, Julie M., Gerrie, Alina S., Grande, Bruno M., Greiner, Timothy, Griner, Nicholas B., Gross, Thomas G., Harris, Nancy L., Irvin, John D., Jaffe, Elaine S., Henry, David, Huppi, Rebecca, Leal, Fabio E., Lee, Michael S., Martin, Jean Paul, Martin, Marie-Reine, Mbulaiteye, Sam M., Mitsuyasu, Ronald, Morris, Vivian, Mullighan, Charles G., Mungall, Andrew J., Mungall, Karen, Mutyaba, Innocent, Nokta, Mostafa, Namirembe, Constance, Noy, Ariela, Ogwang, Martin D., Omoding, Abraham, Orem, Jackson, Ott, German, Petrello, Hilary, Pittaluga, Stefania, Phelan, James D., Ramos, Juan Carlos, Ratner, Lee, Reynolds, Steven J., Rubinstein, Paul G., Sissolak, Gerhard, Slack, Graham, Soudi, Shaghayegh, Swerdlow, Steven H., Traverse-Glehen, Alexandra, Wilson, Wyndham H., Wong, Jasper, Yarchoan, Robert, ZenKlusen, Jean C., Marra, Marco A., Staudt, Louis M., Scott, David W., and Morin, Ryan D.

Published
2023
Full Text
View/download PDF

5. Burkitt lymphoma

Author

López, Cristina, Burkhardt, Birgit, Chan, John K. C., Leoncini, Lorenzo, Mbulaiteye, Sam M., Ogwang, Martin D., Orem, Jackson, Rochford, Rosemary, Roschewski, Mark, and Siebert, Reiner

Published
2022
Full Text
View/download PDF

7. Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Author

Gouveia, Mateus H., Otim, Isaac, Ogwang, Martin D., Wang, Mingyi, Zhu, Bin, Cole, Nathan, Luo, Wen, Hicks, Belynda, Jones, Kristine, Oehl-Huber, Kathrin, Ayers, Leona W., Pittaluga, Stefania, Legason, Ismail D., Nabalende, Hadijah, Kerchan, Patrick, Kinyera, Tobias, Kawira, Esther, Brubaker, Glen, Levin, Arthur G., Guertler, Lutz, Kim, Jung, Stewart, Douglas R., Adde, Melissa, Magrath, Ian, Bergen, Andrew W., Reynolds, Steven J., Yeager, Meredith, Bhatia, Kishor, Adeyemo, Adebowale A., Prokunina-Olsson, Ludmila, Dean, Michael, Shriner, Daniel, Rotimi, Charles N., Chanock, Stephen, Siebert, Reiner, and Mbulaiteye, Sam M.

Published
2021
Full Text
View/download PDF

9. Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma

Author

Liu, Zhiwei, primary, Luo, Yang, additional, Kirimunda, Samuel, additional, Verboom, Murielle, additional, Onabajo, Olusegun O., additional, Gouveia, Mateus H., additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Cole, Nathan, additional, Luo, Wen, additional, Liu, Jia, additional, Manning, Michelle, additional, Hicks, Belynda, additional, Prokunina-Olsson, Ludmila, additional, Chagaluka, George, additional, Johnston, W. Thomas, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N., additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth M., additional, Newton, Robert, additional, Hsing, Ann W., additional, Mensah, James E., additional, Adjei, Anthony A., additional, Hutchinson, Amy, additional, Carrington, Mary, additional, Yeager, Meredith, additional, Blasczyk, Rainer, additional, Chanock, Stephen J., additional, Raychaudhuri, Soumya, additional, and Mbulaiteye, Sam M., additional

Published
2024
Full Text
View/download PDF

10. Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study

Author

Peprah, Sally, Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Otim, Isaac, Legason, Ismail D., Ayers, Leona W., Bhatia, Kishor, Goedert, James J., Pfeiffer, Ruth M., and Mbulaiteye, Sam M.

Published
2021
Full Text
View/download PDF

11. Sickle cell allele HBB‐rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa

Author

Hong, Hyokyoung G., primary, Gouveia, Mateus H., additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Wang, Xunde, additional, Zhou, Jiefu, additional, Leal, Thiago Peixoto, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Mumia, Mediatrix, additional, Baker, Francine S., additional, Okusolubo, Temiloluwa, additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Woo, Joshua, additional, Manning, Michelle, additional, Cole, Nathan, additional, Luo, Wen, additional, Hicks, Belynda, additional, Chagaluka, George, additional, Johnston, W. Thomas, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N., additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth M., additional, Newton, Robert, additional, Hutchinson, Amy, additional, Yeager, Meredith, additional, Adeyemo, Adebowale A., additional, Thein, Swee Lay, additional, Rotimi, Charles N., additional, Chanock, Stephen J., additional, Prokunina‐Olsson, Ludmila, additional, and Mbulaiteye, Sam M., additional

Published
2023
Full Text
View/download PDF

12. IFNL4 Genotypes and Risk of Childhood Burkitt Lymphoma in East Africa

Author

Baker, Francine S., primary, Wang, Jeanny, additional, Florez-Vargas, Oscar, additional, Brand, Nathan R., additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Chagaluka, George, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N., additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth M., additional, Newton, Robert, additional, Prokunina-Olsson, Ludmila, additional, and Mbulaiteye, Sam M., additional

Published
2023
Full Text
View/download PDF

13. A case-control study of Burkitt lymphoma in East Africa: are local health facilities an appropriate source of representative controls?

Author

Baik, Sonya, Mbaziira, Mike, Williams, Makeda, Ogwang, Martin D, Kinyera, Tobias, Emmanuel, Benjamin, Ziegler, John L, Reynolds, Steven J, and Mbulaiteye, Sam M

Abstract

Abstract Background We investigated the feasibility and appropriateness of enrolling controls for Burkitt lymphoma (BL) from local health facilities in two regions in Uganda. Methods BL case data were compiled from two local hospitals with capacity to diagnose and treat BL in North-west and North-central regions of Uganda during 1997 to 2009. Local health facility data were compiled from children attending four representative local health facilities in the two regions over a two week period in May/June 2010. Age and sex patterns of BL cases and children at local facilities were compared and contrasted using frequency tables. Results There were 999 BL cases diagnosed in the study area (92% of all BL cases treated at the hospitals): 64% were from North-central and 36% from North-west region. The mean age of BL cases was 7.0 years (standard deviation [SD] 3.0). Boys were younger than girls (6.6 years versus 7.2 years, P = 0.004) and cases from North-central region were younger than cases from North-west region (6.8 years versus 7.3 years, P = 0.014). There were 1012 children recorded at the four local health facilities: 91% at facilities in North-central region and 9% from facilities in North-west region. Daily attendance varied between 1 to 75 children per day. The mean age of children at health facilities was 2.2 years (SD 2.8); it did not differ by sex. Children at North-central region facilities were younger than children at North-west region facilities (1.8 years versus 6.6 years, P < 0.001). Conclusions While many children attend local health facilities, confirming feasibility of obtaining controls, their mean age is much lower than BL cases. Health facilities may be suitable for obtaining young, but not older, controls.

Published
2012

14. Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya

Author

Redmond, Lawrence S., Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Masalu, Nestory, Kawira, Esther, Otim, Isaac, Legason, Ismail D., Dhudha, Herry, Ayers, Leona W., Bhatia, Kishor, Goedert, James J., and Mbulaiteye, Sam M.

Published
2020
Full Text
View/download PDF

15. Sickle cell allele HBB‐rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa.

Author

Hong, Hyokyoung G., Gouveia, Mateus H., Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Kinyera, Tobias, Wang, Xunde, Zhou, Jiefu, Leal, Thiago Peixoto, Otim, Isaac, Legason, Ismail D., Nabalende, Hadijah, Dhudha, Herry, and Mumia, Mediatrix

Published
2024
Full Text
View/download PDF

16. Author Correction to: Endemic Burkitt lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Author

Gouveia, Mateus H., Otim, Isaac, Ogwang, Martin D., Wang, Mingyi, Zhu, Bin, Cole, Nathan, Luo, Wen, Hicks, Belynda, Jones, Kristine, Oehl-Huber, Kathrin, Ayers, Leona W., Pittaluga, Stefania, Legason, Ismail D., Nabalende, Hadijah, Kerchan, Patrick, Kinyera, Tobias, Kawira, Esther, Brubaker, Glen, Levin, Arthur G., Guertler, Lutz, Kim, Jung, Stewart, Douglas R., Adde, Melissa, Magrath, Ian, Bergen, Andrew W., Reynolds, Steven J., Yeager, Meredith, Bhatia, Kishor, Adeyemo, Adebowale A., Prokunina-Olsson, Ludmila, Dean, Michael, Shriner, Daniel, Rotimi, Charles N., Chanock, Stephen, Siebert, Reiner, and Mbulaiteye, Sam M.

Published
2021
Full Text
View/download PDF

18. Burkitt lymphoma risk shows geographic and temporal associations with Plasmodium falciparum infections in Uganda, Tanzania, and Kenya

Author

Broen, Kelly, primary, Dickens, Joey, additional, Trangucci, Rob, additional, Ogwang, Martin D., additional, Tenge, Constance N., additional, Masalu, Nestory, additional, Reynolds, Steven J., additional, Kawira, Esther, additional, Kerchan, Patrick, additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadija, additional, Buller, Ian D., additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Biggar, Robert J., additional, Goedert, James J., additional, Wilson, Mark L., additional, Mbulaiteye, Sam M., additional, and Zelner, Jon, additional

Published
2023
Full Text
View/download PDF

19. DNA Methylation-Based Burkitt Lymphoma Epitypes Have Distinct Molecular and Clinical Features

Author

Thomas, Nicole, primary, Dreval, Kostiantyn, additional, Gerhard, Daniela S., additional, Hilton, Laura K, additional, Abramson, Jeremy S., additional, Bartlett, Nancy L., additional, Bethony, Jeffrey, additional, Bowen, Jay, additional, Bryan, Anthony, additional, Casper, Corey, additional, Dyer, Maureen, additional, Esteller, Manel, additional, Garcia-Prieto, Carlos, additional, Gastier-Foster, Julie M, additional, Gerrie, Alina S., additional, Grande, Bruno M., additional, Greiner, Timothy C., additional, Griner, Nicholas B., additional, Gross, Thomas G., additional, Harris, Nancy Lee, additional, Irvin, John D., additional, Jaffe, Elaine S., additional, Leal, Fabio, additional, Martin, Jean Paul, additional, Martin, Marie-Reine, additional, Mbulaiteye, Sam M., additional, Mullighan, Charles G., additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Namirembe, Constance, additional, Noy, Ariela, additional, Ogwang, Martin D, additional, Orem, Jackson, additional, Ott, German, additional, Petrello, Hilary, additional, Reynolds, Steven J, additional, Swerdlow, Steven H., additional, Traverse-Glehen, Alexandra, additional, Wilson, Wyndham H., additional, Marra, Marco A., additional, Staudt, Louis M., additional, Scott, David W., additional, and Morin, Ryan D., additional

Published
2022
Full Text
View/download PDF

21. Epstein-Barr Virus in Burkitt Lymphoma in Africa Reveals a Limited Set of Whole Genome and LMP-1 Sequence Patterns: Analysis of Archival Datasets and Field Samples From Uganda, Tanzania, and Kenya

Author

Liao, Hsiao-Mei, primary, Liu, Hebing, additional, Chin, Pei-Ju, additional, Li, Bingjie, additional, Hung, Guo-Chiuan, additional, Tsai, Shien, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Ogwang, Martin D., additional, Reynolds, Steven J., additional, Kerchan, Patrick, additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Ayers, Leona W., additional, Pfeiffer, Ruth M., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Lo, Shyh-Ching, additional, and Mbulaiteye, Sam M., additional

Published
2022
Full Text
View/download PDF

22. Plasma EBV DNA: A Promising Diagnostic Marker for Endemic Burkitt Lymphoma

Author

Xian, Rena R., primary, Kinyera, Tobias, additional, Otim, Isaac, additional, Sampson, Joshua N., additional, Nabalende, Hadijah, additional, Legason, Ismail D., additional, Stone, Jennifer, additional, Ogwang, Martin D., additional, Reynolds, Steven J., additional, Kerchan, Patrick, additional, Bhatia, Kishor, additional, Goedert, James J., additional, Mbulaiteye, Sam M., additional, and Ambinder, Richard F., additional

Published
2021
Full Text
View/download PDF

23. Genetic Subgroups Inform on Pathobiology in Adult and Pediatric Burkitt Lymphoma

Author

Thomas, Nicole, primary, Dreval, Kostiantyn, additional, Gerhard, Daniela S., additional, Hilton, Laura K., additional, Abramson, Jeremy S., additional, Bartlett, Nancy L., additional, Bethony, Jeffrey, additional, Bowen, Jay, additional, Bryan, Anthony C., additional, Casper, Corey, additional, Cruz, Manuela, additional, Dyer, Maureen A., additional, Farinha, Pedro, additional, Gastier-Foster, Julie M., additional, Gerrie, Alina S., additional, Grande, Bruno M., additional, Greiner, Timothy, additional, Griner, Nicholas B., additional, Gross, Thomas G., additional, Harris, Nancy L., additional, Irvin, John D., additional, Jaffe, Elaine S., additional, Leal, Fabio E., additional, Martin, Jean Paul, additional, Martin, Marie-Reine, additional, Mbulaiteye, Sam M., additional, Mullighan, Charles G., additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Namirembe, Constance, additional, Noy, Ariela, additional, Ogwang, Martin D., additional, Orem, Jackson, additional, Ott, German, additional, Petrello, Hilary, additional, Reynolds, Steven J., additional, Slack, Graham, additional, Soudi, Shaghayegh, additional, Swerdlow, Steven H., additional, Traverse-Glehen, Alexandra, additional, Wilson, Wyndham H., additional, Wong, Jasper, additional, Marra, Marco A., additional, Staudt, Louis M., additional, Scott, David W., additional, and Morin, Ryan D., additional

Published
2021
Full Text
View/download PDF

24. Additional file 1 of Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study

Author

Peprah, Sally, Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Otim, Isaac, Legason, Ismail D., Ayers, Leona W., Bhatia, Kishor, Goedert, James J., Pfeiffer, Ruth M., and Mbulaiteye, Sam M.

Abstract

Additional file 1: Supplementary Table 1. Questionnaire variables/data elements and how they were coded for exploratory factor analysis. Supplementary Table 2. Eigenvalue and variance explained by extracted factors shown for each imputed dataset and by study country. Supplementary Table 3. Odds ratios and 95% confidence intervals (CIs) of the association of factors with falciparum infection risk in controls, by country. Supplementary Table 4. Odds ratios and 95% confidence intervals (CIs) of the association of factors with eBL risk, by country.

Published
2021
Full Text
View/download PDF

25. Genomic Landscape of Epstein-Barr Virus in Endemic Burkitt Lymphoma

Author

Legason, Ismail D, Burns, Adam, Ridout, Kate, Jennings, Daisy, Ogwang, Martin D, Otim, Isaac, Nabalende, Hadijah, Achola, Caroline, Ayitewala, Alisen, Sseruyange, Julius, Chamba, Clara C, Josephat, Emmanuel, Christopher, Heavenlight, Mawalla, William F, Mkwizu, Elifurah, Mremi, Alex, Mwamtemi, Hadija, Dreau, Helene, El Mouden, Claire, Vavoulis, Dimitris, Leung, Carol Sze, and Schuh, Anna

Published
2023
Full Text
View/download PDF

26. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

Author

Schmitz, Roland, Young, Ryan M., Ceribelli, Michele, Jhavar, Sameer, Xiao, Wenming, Zhang, Meili, Wright, George, Shaffer, Arthur L., Hodson, Daniel J., Buras, Eric, Liu, Xuelu, Powell, John, Yang, Yandan, Xu, Weihong, Zhao, Hong, Kohlhammer, Holger, Rosenwald, Andreas, Kluin, Philip, Müller-Hermelink, Hans Konrad, Ott, German, Gascoyne, Randy D., Connors, Joseph M., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Ogwang, Martin D., Reynolds, Steven J., Fisher, Richard I., Braziel, Rita M., Tubbs, Raymond R., Cook, James R., Weisenburger, Dennis D., Chan, Wing C., Pittaluga, Stefania, Wilson, Wyndham, Waldmann, Thomas A., Rowe, Martin, Mbulaiteye, Sam M., Rickinson, Alan B., and Staudt, Louis M.

Published
2012
Full Text
View/download PDF

27. Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Author

Gouveia, Mateus H., primary, Otim, Isaac, additional, Ogwang, Martin D., additional, Wang, Mingyi, additional, Zhu, Bin, additional, Cole, Nathan, additional, Luo, Wen, additional, Hicks, Belynda, additional, Jones, Kristine, additional, Oehl-Huber, Kathrin, additional, Ayers, Leona W., additional, Pittaluga, Stefania, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Kerchan, Patrick, additional, Kinyera, Tobias, additional, Kawira, Esther, additional, Brubaker, Glen, additional, Levin, Arthur G., additional, Guertler, Lutz, additional, Kim, Jung, additional, Stewart, Douglas R., additional, Adde, Melissa, additional, Magrath, Ian, additional, Bergen, Andrew W., additional, Reynolds, Steven J., additional, Yeager, Meredith, additional, Bhatia, Kishor, additional, Adeyemo, Adebowale A., additional, Prokunina-Olsson, Ludmila, additional, Dean, Michael, additional, Shriner, Daniel, additional, Rotimi, Charles N., additional, Chanock, Stephen, additional, Siebert, Reiner, additional, and Mbulaiteye, Sam M., additional

Published
2020
Full Text
View/download PDF

28. Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya

Author

Peprah, Sally, primary, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N, additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Mumia, Mediatrix, additional, Ayers, Leona W., additional, Biggar, Robert J., additional, Bhatia, Kishor, additional, Goedert, James J., additional, and Mbulaiteye, Sam M., additional

Published
2020
Full Text
View/download PDF

29. Variation in the Human Leukocyte Antigen system and risk for endemic Burkitt lymphoma in northern Uganda

Author

Kirimunda, Samuel, primary, Verboom, Murielle, additional, Otim, Isaac, additional, Ssennono, Mark, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Kinyera, Tobias, additional, Mwebaza, Ivan, additional, Joloba, Moses, additional, Ayers, Leona W., additional, Reynolds, Steven J., additional, Bhatia, Kishor, additional, Onabajo, Olusegun O., additional, Hallensleben, Michael, additional, Biggar, Robert J., additional, Prokunina‐Olsson, Ludmila, additional, Goedert, James J., additional, Blasczyk, Rainer, additional, and Mbulaiteye, Sam M., additional

Published
2020
Full Text
View/download PDF

31. Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

Author

Derkach, Andriy, Otim, Isaac, Pfeiffer, Ruth M., Onabajo, Olusegun O., Legason, Ismail D., Nabalende, Hadijah, Ogwang, Martin D., Kerchan, Patrick, Talisuna, Ambrose O., Ayers, Leona W., Reynolds, Steven J., Nkrumah, Francis, Neequaye, Janet, Bhatia, Kishor, Theander, Thor G., Prokunina-Olsson, Ludmila, Turner, Louise, Goedert, James J., Lavstsen, Thomas, Mbulaiteye, Sam M., Derkach, Andriy, Otim, Isaac, Pfeiffer, Ruth M., Onabajo, Olusegun O., Legason, Ismail D., Nabalende, Hadijah, Ogwang, Martin D., Kerchan, Patrick, Talisuna, Ambrose O., Ayers, Leona W., Reynolds, Steven J., Nkrumah, Francis, Neequaye, Janet, Bhatia, Kishor, Theander, Thor G., Prokunina-Olsson, Ludmila, Turner, Louise, Goedert, James J., Lavstsen, Thomas, and Mbulaiteye, Sam M.

Abstract

Background: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa. We investigated antibody reactivity to several human receptor-binding domains of the Pf erythrocyte membrane protein 1 (PfEMP1) that play a key role in malaria pathogenesis and are targets of acquired immunity to malaria. Methods: Serum/plasma IgG antibody reactivity was measured to 22 Pf antigens, including 18 to PfEMP1 CIDR domains between cases and controls from two populations (149 eBL cases and 150 controls from Ghana and 194 eBL cases and 600 controls from Uganda). Adjusted odds ratios (aORs) for case-control associations were estimated by logistic regression. Findings: There was stronger reactivity to the severe malaria associated CIDRα1 domains than other CIDR domains both in cases and controls. eBL cases reacted to fewer antigens than controls (Ghana: p = 0·001; Uganda: p = 0·03), with statistically significant lower ORs associated with reactivity to 13+ antigens in Ghana (aOR 0·39, 95% CI 0·24–0·63; pheterogeneity = 0·00011) and Uganda (aOR 0·60, 95% CI 0.41–0·88; pheterogeneity = 0·008). eBL was inversely associated with reactivity, coded as quartiles, to group A variant CIDRδ1 (ptrend = 0·035) in Ghana and group B CD36-binding variants CIDRα2·2 (ptrend = 0·006) and CIDRα2·4 (ptrend = 0·033) in Uganda, and positively associated with reactivity to SERA5 in Ghana (ptrend = 0·017) and Uganda (ptrend = 0·007) and group A CIDRα1·5 variant in Uganda only (ptrend = 0·034). Interpretation: eBL cases reacted to fewer antigens than controls using samples from two populations, Ghana and Uganda. Attenuated humoral immunity to Pf EMP1 may contribute to susceptibility to low-grade malaria and eBL risk. Funding: Intramural Research Program, National Cancer Institute and National Institute of Allergy and Infectious Diseases, Natio

Published
2019

34. Risk factors for Burkitt lymphoma in East African children and minors: A case–control study in malaria‐endemic regions in Uganda, Tanzania and Kenya

Author

Peprah, Sally, primary, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Sumba, Peter O., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Magatti, Josiah, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Ally, Hillary, additional, Genga, Isaiah O., additional, Mumia, Mediatrix, additional, Ayers, Leona W., additional, Pfeiffer, Ruth M., additional, Biggar, Robert J., additional, Bhatia, Kishor, additional, Goedert, James J., additional, and Mbulaiteye, Sam M., additional

Published
2019
Full Text
View/download PDF

35. Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma

Author

Grande, Bruno M., primary, Gerhard, Daniela S., additional, Jiang, Aixiang, additional, Griner, Nicholas B., additional, Abramson, Jeremy S., additional, Alexander, Thomas B., additional, Allen, Hilary, additional, Ayers, Leona W., additional, Bethony, Jeffrey M., additional, Bhatia, Kishor, additional, Bowen, Jay, additional, Casper, Corey, additional, Choi, John Kim, additional, Culibrk, Luka, additional, Davidsen, Tanja M., additional, Dyer, Maureen A., additional, Gastier-Foster, Julie M., additional, Gesuwan, Patee, additional, Greiner, Timothy C., additional, Gross, Thomas G., additional, Hanf, Benjamin, additional, Harris, Nancy Lee, additional, He, Yiwen, additional, Irvin, John D., additional, Jaffe, Elaine S., additional, Jones, Steven J. M., additional, Kerchan, Patrick, additional, Knoetze, Nicole, additional, Leal, Fabio E., additional, Lichtenberg, Tara M., additional, Ma, Yussanne, additional, Martin, Jean Paul, additional, Martin, Marie-Reine, additional, Mbulaiteye, Sam M., additional, Mullighan, Charles G., additional, Mungall, Andrew J., additional, Namirembe, Constance, additional, Novik, Karen, additional, Noy, Ariela, additional, Ogwang, Martin D., additional, Omoding, Abraham, additional, Orem, Jackson, additional, Reynolds, Steven J., additional, Rushton, Christopher K., additional, Sandlund, John T., additional, Schmitz, Roland, additional, Taylor, Cynthia, additional, Wilson, Wyndham H., additional, Wright, George W., additional, Zhao, Eric Y., additional, Marra, Marco A., additional, Morin, Ryan D., additional, and Staudt, Louis M., additional

Published
2019
Full Text
View/download PDF

36. Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"

Author

Gouveia, Mateus H., primary, Bergen, Andrew W., additional, Borda, Victor, additional, Nunes, Kelly, additional, Leal, Thiago P., additional, Ogwang, Martin D., additional, Yeboah, Edward D., additional, Mensah, James E., additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Nabalende, Hadijah, additional, Legason, Ismail D., additional, Mpoloka, Sununguko Wata, additional, Mokone, Gaonyadiwe George, additional, Kerchan, Patrick, additional, Bhatia, Kishor, additional, Reynolds, Steven J., additional, Birtwum, Richard B., additional, Adjei, Andrew A., additional, Tettey, Yao, additional, Tay, Evelyn, additional, Hoover, Robert, additional, Pfeiffer, Ruth M., additional, Biggar, Robert J., additional, Goedert, James J., additional, Prokunina-Olsson, Ludmila, additional, Dean, Michael, additional, Yeager, Meredith, additional, Lima-Costa, M. Fernanda, additional, Hsing, Ann W., additional, Tishkoff, Sarah A., additional, Chanock, Stephen J., additional, Tarazona-Santos, Eduardo, additional, and Mbulaiteye, Sam M., additional

Published
2019
Full Text
View/download PDF

37. Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

Author

Derkach, Andriy, primary, Otim, Isaac, additional, Pfeiffer, Ruth M., additional, Onabajo, Olusegun O., additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Talisuna, Ambrose O., additional, Ayers, Leona W., additional, Reynolds, Steven J., additional, Nkrumah, Francis, additional, Neequaye, Janet, additional, Bhatia, Kishor, additional, Theander, Thor G., additional, Prokunina-Olsson, Ludmila, additional, Turner, Louise, additional, Goedert, James J., additional, Lavstsen, Thomas, additional, and Mbulaiteye, Sam M., additional

Published
2019
Full Text
View/download PDF

38. Risk factors for Burkitt lymphoma in East African children and minors: A case–control study in malaria‐endemic regions in Uganda, Tanzania and Kenya.

Author

Peprah, Sally, Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Sumba, Peter O., Masalu, Nestory, Kawira, Esther, Magatti, Josiah, Kinyera, Tobias, Otim, Isaac, Legason, Ismail D., Nabalende, Hadijah, Dhudha, Herry, Ally, Hillary, Genga, Isaiah O., and Mumia, Mediatrix

Subjects
BURKITT'S lymphoma, MALARIA, HIV seroconversion, CASE-control method, HIV infections, GLUCOSE-6-phosphate dehydrogenase deficiency
Abstract

Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in sub‐Saharan African countries, however, few epidemiologic studies have been undertaken and none attempted enrolling cases from multiple countries. We therefore conducted a population‐based case–control study of eBL in children aged 0–15 years old in six regions in Northern Uganda, Northern Tanzania and Western Kenya, enrolling 862 suspected cases and 2,934 population controls (response rates 98.5–100%), and processing ~40,000 vials of samples using standardized protocols. Risk factor questionnaires were administered, and malaria period prevalence was measured using rapid diagnostic tests (RDTs). A total of 80.9% of the recruited cases were diagnosed as eBL; 61.4% confirmed by histology. Associations with eBL risk were computed using logistic regression models adjusted for relevant confounders. Associations common in at least two countries were emphasized. eBL risk was decreased with higher maternal income and paternal education and elevated with history of inpatient malaria treatment >12 months before enrollment. Reporting malaria‐attributed fever up to 6 months before enrollment and malaria‐RDT positivity at enrollment were associated with decreased eBL risk. Conversely, reporting exposure to mass malaria suppression programs (e.g., indoor residual insecticide) was associated with elevated risk. HIV seropositivity was associated with elevated eBL risk, but the relative impact was small. The study shows that it is feasible to conduct networked, multisite population‐based studies of eBL in Africa. eBL was inversely associated with socioeconomic status, positively associated with inpatient malaria treatment 12 months ago and with living in areas targeted for malaria suppression, which support a role of malaria in eBL. What's new? Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in sub‐Saharan Africa, but there have been few epidemiologic studies. In this multi‐country analysis, the authors used harmonized protocols to investigate infectious, environmental, and other risk factors for eBL. Socioeconomic status and recent malarial fever were associated with reduced eBL risk, while HIV infection, previous malaria, and living in areas targeted for malaria suppression increased eBL risk. These results provide new baseline data regarding eBL epidemiology, indicating that malaria may play a role. They also confirm the feasibility of multi‐site, population‐based enrolment for crucial future eBL studies. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

39. Thirty-day postoperative outcome of patients with non-traumatic gastroduodenal perforations in southwestern Uganda.

Author

Okidi, Ronald, Sambo, Vanusa D, Ogwang, Martin D, Mutiibwa, David, Benitez, Noralis P, and Bongomin, Felix

Subjects
INTESTINAL perforation, ABDOMINAL surgery, MORTALITY
Abstract

We studied our 30-day postoperative outcomes in patients with non-traumatic gastroduodenal perforation (NTGDP) in Mbarara Regional Referral Hospital, southwestern Uganda. We conducted a one-year prospective study of patients who underwent exploratory laparotomy for suspected NTGDP between June 2016 and July 2017. Twenty-nine patients had NTGDP, the male-to-female ratio was 3:1 and median age was 60 years (range = 13-80 years). Most (83%) patients were negative for Helicobacter pylori on histology. One patient had a gastric adenocarcinoma. A total of 26 (90%) patients had Graham's omentopexy performed. The 30-day mortality rate was 34%. Pyrexia at hospital admission, pre-surgical delay (> 72 h), preoperative shock and peritoneal contamination, were associated with higher mortality rates with preoperative shock being an independent predictor of mortality. H. pylori-negative NTGDP presents a unique challenge in our setting, affecting mainly middle-aged and elderly patients. One-third of our patients did not survive one month. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

40. Erratum to “Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda” [Cancer Epidemiol. 52 (2018) 70–74]

Author

Ravell, Juan, primary, Otim, Isaac, additional, Nabalende, Hadijah, additional, Legason, Ismail D., additional, Reynolds, Steven J., additional, Ogwang, Martin D., additional, Ndugwa, Christopher M., additional, Marshall, Vickie, additional, Whitby, Denise, additional, Goedert, James J., additional, Engels, Eric A., additional, Bhatia, Kishor, additional, Lenardo, Michael J., additional, and Mbulaiteye, Sam M., additional

Published
2018
Full Text
View/download PDF

41. Cango Lyec (Healing the Elephant): Gender Differences in HIV Infection in Post-conflict Northern Uganda

Author

Spittal, Patricia M., primary, Malamba, Samuel S., additional, Ogwang, Martin D., additional, Musisi, Seggane, additional, Ekwaru, J. Paul, additional, Sewankambo, Nelson K., additional, Pearce, Margo E., additional, Jongbloed, Kate, additional, Patel, Sheetal H., additional, Katamba, Achilles, additional, Blair, Alden H., additional, Muyinda, Herbert, additional, and Schechter, Martin T., additional

Published
2018
Full Text
View/download PDF

42. Accuracy of burkitt lymphoma diagnosis in constrained pathology settings: importance to epidemiology

Author

Ogwang, Martin D., Zhao, Weiqiang, Ayers, Leona W., and Mbulaiteye, Sam M.

Subjects
Immunohistochemistry, Non-Hodgkin's lymphomas, Formaldehyde, Epidemiology, Burkitt's lymphoma, Health
Abstract

Context.--Burkitt lymphoma (BL) is endemic in Uganda and because of the high incidence, diagnosis is often presumed during clinical care and epidemiologic studies. Objectives.--To assess the accuracy of the clinical and the local pathology diagnosis of BL as assessed by an outside pathology review diagnosis and to understand the limitations on histopathology practice in a resource-constrained setting at 1 hospital in Uganda. Design.--Clinically presumed pediatric ( Results.--Local pathology laboratory procedures were inconsistent and suboptimal, especially for tissue fixation. There were 88 clinically presumed BL cases. Sixty-three could be reviewed by outside pathology (25 cases of lost blocks or no remaining tumor) and showed a clinical diagnostic accuracy of 75% (47 confirmed of 63), with a possible range of 62% to 85%, depending on the actual diagnosis of the 25 nonevaluable cases. There were 64 BL cases diagnosed by local pathology. Forty-five could be reviewed by outside pathology (19 cases of lost blocks or no remaining tumor) and showed a local pathology diagnostic accuracy of 82% (37 confirmed of 45), with a possible range of 58% to 88%, depending on the actual diagnosis of the 19 nonevaluable cases. Non-BL diagnoses included other non-Hodgkin lymphomas, Hodgkin lymphoma, and benign infectious lymphadenopathy. Conclusions.--Accuracy of clinical diagnosis of BL was reduced by inclusion of other diseases with similar clinical presentations. Local pathology, using morphology alone, only marginally improved clinical accuracy and often could not support outside pathology review due to inadequate laboratory procedures. There is an urgent need to improve pathology services in Uganda before conducting high-quality clinical and epidemiologic studies., Accurate and reliable histopathology diagnosis is critical for confirmation of significant diseases, disease classification, disease registration, and clinical and epidemiologic studies, especially of cancer. Fewer than 50% of cancers in [...]

Published
2011

43. Evaluating the Causal Link Between Malaria Infection and Endemic Burkitt Lymphoma in Northern Uganda: A Mendelian Randomization Study

Author

Legason, Ismail D., primary, Pfeiffer, Ruth M., additional, Udquim, Krizia-Ivana, additional, Bergen, Andrew W., additional, Gouveia, Mateus H., additional, Kirimunda, Samuel, additional, Otim, Isaac, additional, Karlins, Eric, additional, Kerchan, Patrick, additional, Nabalende, Hadijah, additional, Bayanjargal, Ariunaa, additional, Emmanuel, Benjamin, additional, Kagwa, Paul, additional, Talisuna, Ambrose O., additional, Bhatia, Kishor, additional, Yeager, Meredith, additional, Biggar, Robert J., additional, Ayers, Leona W., additional, Reynolds, Steven J., additional, Goedert, James J., additional, Ogwang, Martin D., additional, Fraumeni, Joseph F., additional, Prokunina-Olsson, Ludmila, additional, and Mbulaiteye, Sam M., additional

Published
2017
Full Text
View/download PDF

44. Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda

Author

Maziarz, Marlena, primary, Kinyera, Tobias, additional, Otim, Isaac, additional, Kagwa, Paul, additional, Nabalende, Hadijah, additional, Legason, Ismail D., additional, Ogwang, Martin D., additional, Kirimunda, Samuel, additional, Emmanuel, Benjamin, additional, Reynolds, Steven J., additional, Kerchan, Patrick, additional, Joloba, Moses M., additional, Bergen, Andrew W., additional, Bhatia, Kishor, additional, Talisuna, Ambrose O., additional, Biggar, Robert J., additional, Goedert, James J., additional, Pfeiffer, Ruth M., additional, and Mbulaiteye, Sam M., additional

Published
2017
Full Text
View/download PDF

45. Burkitt Lymphoma Genome Sequencing Project (BLGSP): Introduction

Author

Gerhard, Daniela S, primary, Grande, Bruno, additional, Griner, Nicholas, additional, Casper, Corey, additional, Gerdts, Sarah E., additional, Omoding, Abraham, additional, Orem, Jackson, additional, Mbulaiteye, Sam M, additional, Ogwang, Martin D., additional, Reynolds, Steven J., additional, Bhatia, Kishor, additional, Ayers, Leona, additional, Choi, John K, additional, Mullighan, Charles G., additional, Sandlund, John T., additional, Alexander, Thomas B., additional, Abramson, Jeremy S., additional, Gross, Thomas G., additional, Noy, Ariela, additional, Bethony, Jeffrey, additional, Leal, Fabio, additional, Greiner, Timothy C, additional, Jaffe, Elaine S., additional, Harris, Nancy Lee, additional, Gastier-Foster, Julie M., additional, Bowen, Jay, additional, Hanf, Benjamin, additional, Schmitz, Roland, additional, Martin, Jean-Paul, additional, Martin, Marie-Reine, additional, Irvin, John D., additional, Miller, Ellen, additional, Gesuwan, Patee, additional, Hermida, Leandro C., additional, Davidsen, Tanja M., additional, Mungall, Andrew J., additional, Ma, Yussanne, additional, Marra, Marco A., additional, Morin, Ryan D., additional, and Staudt, Louis M., additional

Published
2016
Full Text
View/download PDF

46. “The Cango Lyec Project - Healing the Elephant”: HIV related vulnerabilities of post-conflict affected populations aged 13–49 years living in three Mid-Northern Uganda districts

Author

Malamba, Samuel S., primary, Muyinda, Herbert, additional, Spittal, Patricia M., additional, Ekwaru, John P., additional, Kiwanuka, Noah, additional, Ogwang, Martin D., additional, Odong, Patrick, additional, Kitandwe, Paul K., additional, Katamba, Achilles, additional, Jongbloed, Kate, additional, Sewankambo, Nelson K., additional, Kinyanda, Eugene, additional, Blair, Alden, additional, and Schechter, Martin T., additional

Published
2016
Full Text
View/download PDF

49. Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma

Author

Thomas, Nicole, Dreval, Kostiantyn, Gerhard, Daniela S., Hilton, Laura K., Abramson, Jeremy S., Ambinder, Richard F., Barta, Stefan, Bartlett, Nancy L., Bethony, Jeffrey, Bhatia, Kishor, Bowen, Jay, Bryan, Anthony C., Cesarman, Ethel, Casper, Corey, Chadburn, Amy, Cruz, Manuela, Dittmer, Dirk P., Dyer, Maureen A., Farinha, Pedro, Gastier-Foster, Julie M., Gerrie, Alina S., Grande, Bruno M., Greiner, Timothy, Griner, Nicholas B., Gross, Thomas G., Harris, Nancy L., Irvin, John D., Jaffe, Elaine S., Henry, David, Huppi, Rebecca, Leal, Fabio E., Lee, Michael, Martin, Jean Paul, Martin, Marie-Reine, Mbulaiteye, Sam M., Mitsuyasu, Ronald, Morris, Vivian, Mullighan, Charles G., Mungall, Andrew J., Mungall, Karen, Mutyaba, Innocent, Nokta, Mostafa, Namirembe, Constance, Noy, Ariela, Ogwang, Martin D., Omoding, Abraham, Orem, Jackson, Ott, German, Petrello, Hilary, Pittaluga, Stefania, Phelan, James D., Ramos, Juan Carlos, Ratner, Lee, Reynolds, Steven J., Rubinstein, Paul, Sissolak, Gerhard, Slack, Graham, Soudi, Shaghayegh, Swerdlow, Steven H., Traverse-Glehen, Alexandra, Wilson, Wyndham H., Wong, Jasper, Yarchoan, Robert, ZenKlusen, Jean C., Marra, Marco A., Staudt, Louis M., Scott, David W., and Morin, Ryan D.

Abstract

Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less common but significantly more lethal when diagnosed in adults. Much of the knowledge of the genetics of BL thus far has originated from the study of pediatric BL (pBL), leaving its relationship to adult BL (aBL) and other adult lymphomas not fully explored. We sought to more thoroughly identify the somatic changes that underlie lymphomagenesis in aBL and any molecular features that associate with clinical disparities within and between pBL and aBL. Through comprehensive whole-genome sequencing of 230 BL and 295 diffuse large B-cell lymphoma (DLBCL) tumors, we identified additional significantly mutated genes, including more genetic features that associate with tumor Epstein-Barr virus status, and unraveled new distinct subgroupings within BL and DLBCL with 3 predominantly comprising BLs: DGG-BL (DDX3X, GNA13, and GNAI2), IC-BL (ID3and CCND3), and Q53-BL (quiet TP53). Each BL subgroup is characterized by combinations of common driver and noncoding mutations caused by aberrant somatic hypermutation. The largest subgroups of BL cases, IC-BL and DGG-BL, are further characterized by distinct biological and gene expression differences. IC-BL and DGG-BL and their prototypical genetic features (ID3and TP53) had significant associations with patient outcomes that were different among aBL and pBL cohorts. These findings highlight shared pathogenesis between aBL and pBL, and establish genetic subtypes within BL that serve to delineate tumors with distinct molecular features, providing a new framework for epidemiologic, diagnostic, and therapeutic strategies.

Published
2022
Full Text
View/download PDF

50. 'The Cango Lyec Project - Healing the Elephant': HIV related vulnerabilities of post-conflict affected populations aged 13–49 years living in three Mid-Northern Uganda districts

Author

Malamba, Samuel S, Muyinda, Herbert, Spittal, Patricia M, Ekwaru, John P, Kiwanuka, Noah, Ogwang, Martin D, Odong, Patrick, Kitandwe, Paul K, Katamba, Achilles, Jongbloed, Kate, Sewankambo, Nelson K, Kinyanda, Eugene, Blair, Alden, and Schechter, Martin T

Subjects
10. No inequality, 3. Good health
Abstract

Background: The protracted war between the Government of Uganda and the Lord’s Resistance Army in Northern Uganda (1996–2006) resulted in widespread atrocities, destruction of health infrastructure and services, weakening the social and economic fabric of the affected populations, internal displacement and death. Despite grave concerns that increased spread of HIV/AIDS may be devastating to post conflict Northern Uganda, empirical epidemiological data describing the legacy of the war on HIV infection are scarce. Methods: The ‘Cango Lyec’ Project is an open cohort study involving conflict-affected populations living in three districts of Gulu, Nwoya and Amuru in mid-northern Uganda. Between November 2011 and July 2012, 8 study communities randomly selected out of 32, were mapped and house-to-house census conducted to enumerate the entire community population. Consenting participants aged 13–49 years were enrolled and interviewer-administered data were collected on trauma, depression and socio-demographic-behavioural characteristics, in the local Luo language. Venous blood was taken for HIV and syphilis serology. Multivariable logistic regression was used to determine factors associated with HIV prevalence at baseline. Results: A total of 2954 participants were eligible, of whom 2449 were enrolled. Among 2388 participants with known HIV status, HIV prevalence was 12.2% (95%CI: 10.8-13.8), higher in females (14.6%) than males (8.5%, p

Catalog

Books, media, physical & digital resources
See catalog results