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12 results on '"Ogunbiyi, Olumide K."'

3. Anti-CD45 PBD-based antibody-drug conjugates are effective targeted conditioning agents for gene therapy and stem cell transplant

Author

Yeung, Jenny, Liao, Aiyin, Shaw, Matthew, Silva, Soraia, Vetharoy, Winston, Rico, Diego Leon, Kirby, Ian, Zammarchi, Francesca, Havenith, Karin, de Haan, Lolke, van Berkel, Patrick H., Sebire, Neil, Ogunbiyi, Olumide K., Booth, Claire, Gaspar, H. Bobby, Thrasher, Adrian J., Chester, Kerry A., and Amrolia, Persis J.

Published
2024
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5. The transcriptomic landscape of monosomy X (45,X) during early human fetal and placental development

Author

Suntharalingham, Jenifer P, primary, del Valle, Ignacio, additional, Buonocore, Federica, additional, McGlacken-Byrne, Sinead M, additional, Brooks, Tony, additional, Ogunbiyi, Olumide K, additional, Liptrot, Danielle, additional, Dunton, Nathan, additional, Madhan, Gaganjit K, additional, Metcalfe, Kate, additional, Nel, Lydia, additional, Marshall, Abigail R, additional, Ishida, Miho, additional, Sebire, Neil J, additional, Moore, Gudrun E, additional, Crespo, Berta, additional, Solanky, Nita, additional, Conway, Gerard S, additional, and Achermann, John C, additional

Published
2024
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6. Single-nucleus RNA-sequencing reveals novel potential mechanisms of ovarian insufficiency in 45,X Turner Syndrome

Author

McGlacken-Byrne, Sinead M, primary, Del Valle, Ignacio, additional, Xenakis, Theodoros, additional, Suntharalingham, Jenifer P, additional, Nel, Lydia, additional, Liptrot, Danielle, additional, Crespo, Berta, additional, Ogunbiyi, Olumide K, additional, Niola, Paola, additional, Brooks, Tony, additional, Solanky, Nita, additional, Conway, Gerard S, additional, and Achermann, John C, additional

Published
2023
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7. An integrated single-cell analysis of human adrenal cortex development

Author

del Valle, Ignacio, primary, Young, Matthew D., additional, Kildisiute, Gerda, additional, Ogunbiyi, Olumide K., additional, Buonocore, Federica, additional, Simcock, Ian C., additional, Khabirova, Eleonora, additional, Crespo, Berta, additional, Moreno, Nadjeda, additional, Brooks, Tony, additional, Niola, Paola, additional, Swarbrick, Katherine, additional, Suntharalingham, Jenifer P., additional, McGlacken-Byrne, Sinead M., additional, Arthurs, Owen J., additional, Behjati, Sam, additional, and Achermann, John C., additional

Published
2023
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8. Advanced x-ray imaging techniques in tissue engineering: a new construct assessment platform for enabling the regeneration of personalised organs

Author

Savvidis, Savvas, primary, Gerli, Mattia F., additional, Citro, Antonio, additional, Massimi, Lorenzo, additional, Hagen, Charlotte K., additional, Endrizzi, Marco, additional, Atzeni, Alessia, additional, Astolfo, Alberto, additional, Esposito, Michela, additional, Ogunbiyi, Olumide K., additional, Turmaine, Mark, additional, Smith, Elizabeth S., additional, Cipiccia, Silvia, additional, Rau, Christoph, additional, Li, Peng, additional, Lutman, Roberto, additional, Selmin, Giulia, additional, Durkin, Natalie, additional, Shibuya, Soichi, additional, Scuglia, Marianna, additional, Pellegrini, Marco, additional, De Coppi, Paolo, additional, and Olivo, Alessandro, additional

Published
2023
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9. A cell atlas of human adrenal cortex development and disease

Author

del Valle, Ignacio, primary, Young, Matthew D, additional, Kildisiute, Gerda, additional, Ogunbiyi, Olumide K, additional, Buonocore, Federica, additional, Simcock, Ian C, additional, Khabirova, Eleonora, additional, Crespo, Berta, additional, Moreno, Nadjeda, additional, Brooks, Tony, additional, Niola, Paola, additional, Swarbrick, Katherine, additional, Suntharalingham, Jenifer P, additional, McGlacken-Byrne, Sinead M, additional, Arthurs, Owen J, additional, Behjati, Sam, additional, and Achermann, John C, additional

Published
2022
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10. Advanced x-ray imaging techniques in tissue engineering: a new construct assessment platform for enabling the regeneration of personalised organs

Author

Gimi, Barjor S., Krol, Andrzej, Savvidis, Savvas, Gerli, Mattia F. M., Citro, Antonio, Massimi, Lorenzo, Hagen, Charlotte K., Endrizzi, Marco, Atzeni, Alessia, Astolfo, Alberto, Esposito, Michela, Ogunbiyi, Olumide K., Turmaine, Mark, Smith, Elizabeth S., Cipiccia, Silvia, Rau, Christoph, Li, Peng, Lutman, Roberto, Selmin, Giulia, Durkin, Natalie, Shibuya, Soichi, Scuglia, Marianna, Pellegrini, Marco, De Coppi, Paolo, and Olivo, Alessandro

Published
2023
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11. Advanced x-ray imaging techniques in tissue engineering: a new construct assessment platform for enabling the regeneration of personalised organs.

Author

Savvidis, Savvas, Gerli, Mattia F. M., Citro, Antonio, Massimi, Lorenzo, Hagen, Charlotte K., Endrizzi, Marco, Atzeni, Alessia, Astolfo, Alberto, Esposito, Michela, Ogunbiyi, Olumide K., Turmaine, Mark, Smith, Elizabeth S., Cipiccia, Silvia, Rau, Christoph, Li, Peng, Lutman, Roberto, Selmin, Giulia, Durkin, Natalie, Shibuya, Soichi, and Scuglia, Marianna

Published
2023
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12. Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency.

Author

McGlacken-Byrne SM, Del Valle I, Quesne Stabej PL, Bellutti L, Garcia-Alonso L, Ocaka LA, Ishida M, Suntharalingham JP, Gagunashvili A, Ogunbiyi OK, Mistry T, Buonocore F, Crespo B, Moreno N, Niola P, Brooks T, Brain CE, Dattani MT, Kelberman D, Vento-Tormo R, Lagos CF, Livera G, Conway GS, and Achermann JC

Subjects
Adenosine analogs & derivatives, Adenosine genetics, Adenosine metabolism, Female, Humans, Meiosis, Primary Ovarian Insufficiency genetics, RNA Helicases genetics
Abstract

Primary ovarian insufficiency (POI) affects 1% of women and carries significant medical and psychosocial sequelae. Approximately 10% of POI has a defined genetic cause, with most implicated genes relating to biological processes involved in early fetal ovary development and function. Recently, Ythdc2, an RNA helicase and N6-methyladenosine reader, has emerged as a regulator of meiosis in mice. Here, we describe homozygous pathogenic variants in YTHDC2 in 3 women with early-onset POI from 2 families: c. 2567C>G, p.P856R in the helicase-associated (HA2) domain and c.1129G>T, p.E377*. We demonstrated that YTHDC2 is expressed in the developing human fetal ovary and is upregulated in meiotic germ cells, together with related meiosis-associated factors. The p.P856R variant resulted in a less flexible protein that likely disrupted downstream conformational kinetics of the HA2 domain, whereas the p.E377* variant truncated the helicase core. Taken together, our results reveal that YTHDC2 is a key regulator of meiosis in humans and pathogenic variants within this gene are associated with POI.

Published
2022
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