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Spine injuries involve 1 to 5% of children admitted to trauma centers and a high index of suspicion is warranted owing to the potential severe consequences of unstable lesions. Evaluation of cervical and lumbar trauma in children requires an understanding of developmental anatomy to differentiate trauma from age-appropriate findings. Generally speaking, young children more often have ligamentous injuries, whereas older children and adolescents have bone injuries as the spine takes on adult features. The aim of this review is to provide a concise overview of the major aspects involved in spine injuries detection and management in children. Epidemiology is discussed first, and then appropriate precautions and paediatric spine immobilization protocols are presented. Details of paediatric spine radiological anatomy are included and our institutional spine clearance protocol is discussed. Lastly, a short paragraph is devoted to analyze treatment of spinal cord injuries in children and halo immobilization. [ABSTRACT FROM AUTHOR]

A survey of hemoglobinopathies in northern Sardinia revealed a high frequency (0.3%) of carriers of a hematologic condition characterized by increased expression of fetal hemoglobin during adult life (hereditary persistence of fetal hemoglobin or HPFH). In spite of a normal hematologic phenotype, the heterozygous carriers for this condition display about 12% HbF, almost exclusively of the γ type; compound heterozygotes with β-thalassemia have 20%-26% HbF and run a very mild clinical course. The sequence analysis of the cloned γ gene linked to the HPFH determinant revealed the presence of a G→A substitution at position-117 of the γ- gene promoter; the same mutation occurs also in Greek HPFH, although associated with different restriction polymorphisms. Another hereditary condition characterized by increased HbF (αγ) level and a mild thalassemic phenotype in Sardinia is associated with the-196 C→T substitution in the γ-globin gene promoter (Sardinian δβ-thalassemia). Population studies using oligonucleotides complementary both to the-117 G→A and-196 C→T mutations and the corresponding normal sequences confirm the presence of these mutations only in HPFH and δβ-thalassemia chromosomes and exclude these changes being common DNA polymorphisms. [ABSTRACT FROM AUTHOR]

An athlete's posture has a significant impact on aerodynamic drag. Although aerodynamic drag in different sports has been studied extensively, most studies have analysed only a limited number of positions, and no generalized methods for optimization are available. In this work, we present a methodology to perform athlete posture optimization with respect to aerodynamic drag reduction. The method combines the virtual skeleton methodology to adjust the athlete's posture, CFD simulations to evaluate the drag for a given posture, and efficient global optimization to find the optimum position. We demonstrate the method by optimizing the time trial position for a cyclist. The cyclist position was parameterized with 6 design parameters, and the optimization required 41 CFD simulations to converge. The optimal posture yielded a reduction in drag of 17 % compared to the initial posture (disregarding bicycle drag). The method has potential to make posture optimization more accessible across a wide range of sports, and lead to insight into the aerodynamic influence of posture in general., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Background: The relationship between physical activity and low back pain (LBP) in adolescents is complex, with conflicting evidence on whether activity is protective or a risk factor. The COVID-19 pandemic has introduced new challenges, increasing sedentary behaviors among adolescents. This systematic review updates the evidence on the association between physical activity and LBP in this population, focusing on the impact of the pandemic. Methods: A systematic search of PubMed, Cochrane Library, Web of Science, Medline, and SCOPUS identified observational studies published between January 2011 and December 2023. This review focused on adolescents aged 10 to 19 years, examining the effects of various physical activity levels and types on LBP incidence. Quality assessment was conducted using the ROBINS-I tool. Results: Twelve studies were included, with a total of 78,850 adolescents. The findings suggest a U-shaped relationship between physical activity and LBP, where low and high activity levels increase LBP risk, while moderate activity appears protective. The pandemic exacerbated LBP prevalence, likely due to increased sedentary behavior. Gender differences were noted, with females more likely to report LBP, particularly related to sports participation. Conclusions: Moderate physical activity may protect against LBP in adolescents, whereas both inactivity and excessive activity heighten risk. The pandemic's impact highlights the need for balanced physical activity to prevent LBP. Further research should explore the long-term effects of these changes.

Purpose: Magnetic growing rods (MGRs) are one of the most common procedures to treat early-onset scoliosis (EOS). Radiographic examinations (X-ray) or ultrasonographic (US) assessments are used to evaluate the lengthening of the rods. X-ray exposes patients to radiation, while the US has not been validated and may be affected by the radiologist's ability to assess elongation. The research question of the present study is to compare the difference between US and X-ray growth assessments in EOS patients treated with MGRs., Methods: The study enrolled 65 patients consecutively from July 2011 to July 2022. Noninvasive lengthening was performed every four months, and X-ray follow-up was performed at different intervals. An experienced radiologist assessed the mean US rod elongation per session. The mean elongation/session of T2-T12 and T2-S1 was calculated, and the results were compared using an independent t-test., Results: The mean age at operation was 8.8 ± 2 years, and the mean follow-up was four ± two years. The average rod elongation assessed by the US was 3.1 ± 0.1 mm. The average rod elongation evaluated by X-ray was 1.2 ± 2.9 mm (T2-T12) and 1.8 ± 1.9 mm (T2-S1). The difference between the values measured by US and X-ray was statistically significant in the T2-T12 group (p < 0.05) and not significant in the T2-S1 group (p = 0.34)., Conclusions: This is the most extensive single-center study comparing US and X-ray data for MGRs in EOS patients. US overestimates thoracic spine elongation compared to X-ray. US elongation analysis could be appropriate in long thoracolumbar curves., (© 2023. The Author(s) under exclusive licence to SICOT aisbl.)

Introduction: Magnetic controlled growing rods (MCGRs) are one of the most common procedures to treat early-onset scoliosis (EOS). One of the major concerns is that patients treated with MGCR do not reach an adequate height with MGCR. The present study has one of the largest sample sizes of EOS patients treated by MGCR. This study aims to demonstrate the efficacy of the treatment with MGCR in EOS patients, comparing our results with the estimated growth., Methods: Patients were consecutively enrolled from July 2011 to July 2022. The same surgical equipe performed all the procedures. The mean length of the patients was assessed by X-ray (T2-T12 and T2-S1 distance) by a team of expert radiologists. The estimated growth by Dimeglio was compared with the mean elongation obtained by year., Results: 65 patients were included. 16 patients underwent final surgery. In group 1, patients reached a growth of 3.6 ± 8.7 mm (T2-T12) and 9.6 ± 27.6 mm (T2-S1). In group 2, patients grew 5.4 ± 5.7 mm (T2-T12) and 9 ± 9 mm (T2-S1).81% of the estimated elongation during the treatment was obtained during the first surgery. The difference between Dimeglio's estimated growth and the value obtained by MGCR was -4.3 ± 8.7 mm(T2-T12) and -12.3 ± 12.2 mm (T2-S1) in group 1 (p < 0.001) and -1.1 ± 4.2 mm (T2-T12) and -6.6 ± 6.0 mm (T2-S1) in group 2 (p = 0.001)., Conclusions: MGCR patients reached and overlapped the growth target according to the score by Dimeglio. However, the value of growth tended to reduce over the years. Lastly, obtaining the most significant elongation possible at the first surgery is mandatory, comprising 81% of the total value., (© 2024. The Author(s), under exclusive licence to Scoliosis Research Society.)

Background: Flatfoot is a common condition in young patients, but usually resolves by adolescence. This study aimed to estimate annual trend hospitalizations for flatfoot in Italian paediatric population from 2001 to 2016., Methods: Data of this study were collected from the National Hospital Discharge Reports (SDO) reported at the Italian Ministry of Health regarding the years of this paper (2001-2016). The yearly number of hospital admission for flatfoot, the percentage of males and females, the average age, the average days of hospitalization, primary diagnoses and primary procedures in the whole Italian population were calculated using descriptive statistical analyses., Results: 109,300 hospitalizations for flatfoot of young patients were performed during this period. 59.3% of patients were male and 40.7% female of the 10-14 years-old age class. The average days of hospitalization stay were 1.73 ± 1.27 days. The data highlights that the burden of flatfoot surgery is growing and affecting the healthcare system. The mean rate of hospital admissions in Italy for flatfoot in the young population was 82.14 for 100,000 inhabitants of the same age class., Conclusions: The data highlights that the cases of flatfoot surgery increased from 2001 to 2016. The most common treatment was the "Internal Fixation Of Bone Without Fracture Reduction, Tarsals And Metatarsals followed by Subtalar Fusion and Arthroereisis. Further prospective studies on this topic may be conducted to improve the evidence of the results., (© 2022. The Author(s).)

Background: Subtalar Joint Arthroereisis (SJA) is the most used technique for the treatment of flexible flatfoot. Limited data are reported to trends of hospitalisation for SJA. This study aimed to estimate annual admissions and the geographical distribution of SJA in young Italian patients from 2009 to 2016., Methods: Data of this study were collected from the National Hospital Discharge Reports reported at the Italian Ministry of Health. The yearly number of SJA, sex, age and days of hospitalisation were calculated. Public and Private hospitalisations have been analysed individually., Results: 1.6762 hospitalisations for SJA were performed in Italy during the study period, and the incidence increased from 8.22 to 117.08 (cases/100,000 inhabitants). Men represented the majority of young patients treated by SJA. The mean length of stay was 1.55 ± 0.818 days., Conclusions: The prevalence of admissions of young patients for SJA increases from 2009 to 2016. The majority of the procedure was performed in public hospitals, but a shorter length of stay was reported in patients treated in private hospitals (p < 0.001). This study highlighted the limits of ICD-9; in fact, difficulties in procedure codification and heterogeneity in diagnosis and procedures performed were reported., (Copyright © 2021 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.)

Background: Slipped capital femoral epiphysis (epiphysiolysis of the femoral head, SCFE) is the most common pediatric hip disease in 10-14 years old children. The most used procedure to correct a stable form of SCFE is in situ pinning. Instead, the proper treatment for unstable forms is controversial. The first purpose of this study was to estimate annual admissions for SCFE in Italian patients from 2001 to 2015, basing on the hospitalization reports. The second aim was to assess the difference between regions regarding SCFE procedures. Lastly, a statistical prediction of the volume of SCFE procedures performed in Italy based on data from 2001 to 2015 was performed., Methods: Data of this study were collected from the National Hospital Discharge Reports (SDO) reported at the Italian Ministry of Health regarding the years of this paper. The yearly number of hospital admission for SCFE, the percentage of males and females, the average age, days of hospitalization, primary diagnoses and primary procedures in the whole Italian population were calculated using descriptive statistical analyses., Results: From 2001 to 2015, 4893 hospitalizations for SCFE were recorded in Italy, with a mean incidence of 2.9 (cases/100.000 inhabitants). The majority of patients treated by SCFE were males (70.6%)., Conclusion: National health statistics for SCFE are attractive for an international audience, as different approaches to screening are reported between countries. These differences allow comparing outcomes internationally. Moreover, sharing national statistics and correlating those to other countries protocols, could be helpful to compare outcomes for different procedures internationally. However, further studies are required to understand the specific reasons for regional variation for SCFE procedures in Italy., Level of Evidence: III.

Developmental Dysplasia of the Hip (DDH) includes a broad spectrum of hip abnormalities. DDH requires early diagnosis and treatment; however, no international consensus on screening protocol and treatment is provided in the literature. Epidemiological studies are helpful to understand the national variation of a specific surgical procedure and compare it with that of other countries. Data provided by different countries could allow researchers to provide international guidelines for DDH screening and treatment. Limited data are reported regarding trends of hospitalization for DDH, and no public database is available. The purpose of this study was to estimate annual admissions for DDH in Italian patients from 2001 to 2016, based on the hospitalization reports. Data of this study were collected from the National Hospital Discharge Reports (SDO) reported at the Italian Ministry of Health. Descriptive statistical analyses were performed. From 2001 to 2016, 3103 hospitalizations for DDH were recorded in Italy, with a mean incidence of 2.33 (per 100,000 young inhabitants). Females of the 0-4 years old group represented the majority of patients hospitalized for DDH.

The purpose of this investigation was to examine the aerodynamics of tucked positions in competitive alpine skiing. To further our understanding of how a skier's position affects the air flow and the resulting aerodynamic drag, a combination of both experimental and simulation methods was used. This study focused in particular on the effect of skier torso and thigh angles relative to the air flow direction, as these two angles have been previously found to be important determinants of aerodynamic performance in tucked positions. Two top 30 world-ranked skiers were investigated in two different wind tunnels, and the results were compared with Computational Fluid Dynamics (CFD) simulations performed using a 3D scan of one of the athlete. To quantify the effect of torso and thigh angles on skier drag, changes in drag were measured relative to baseline positions. Skier drag area increased by approximately 0.8 and 1.2% per degree increase in torso and thigh angles relative to the baseline position, respectively. This trend was consistent between both of the experimental wind tunnel tests as well as the CFD simulations, indicating good agreement between methods. The CFD simulations further indicated that the air flow about the lower legs made the largest contribution to skier drag, accounting for as much as 40-50% of the total drag area in low tuck positions. Based on these findings, a low tuck position where the torso angle approaches 0° and the knees help to fill the gap behind the armpits will minimize skier aerodynamic drag., Competing Interests: Declaration of Competing Interest The authors report no conflict of interest., (Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Objective: Preoperative planning in spine surgery is a fundamental step of the surgical workup and is often assisted by direct visualization of anatomical 2-dimensional images. This process is time-consuming and may excessively approximate the 3-dimensional (3D) nature of spinal anatomy. Virtual reality (VR) is an emerging technology capable of reconstructing an interactive 3D anatomical model that can be freely explored and manipulated., Methods: Sixty patients with adolescent idiopathic scoliosis underwent correction of the scoliotic curve by posterior arthrodesis after preoperative planning using traditional on-screen visualization of computed tomography scans (control group, n = 30) or exploration of a 3D anatomical model in VR using Google Cardboard (Google Inc.) (VR group, n = 30). Mean operative time, blood loss, length of hospital stay, and surgeon's satisfaction were assessed after surgery., Results: The use of VR led to a significant decrease in operative time and bleeding while increasing the surgeon's satisfaction compared to the control group., Conclusion: Preoperative planning with VR turned out to be effective in terms of operative time and blood loss reduction. Moreover, such technology proved to be reproducible, costeffective, and more satisfactory compared to conventional planning.

Background: A new method for the management of early-onset scoliosis (EOS) has been recently introduced: it consists of a magnetically controlled growing rod (MCGR) that allows gradual outpatient distractions under control of an external remote device. The aim of the present study is to present a series of 10 patients with EOS managed with MCGR (Ellipse TM MAGEC System, Irvine, CA)., Methods: We implanted MCGR in 10 patients affected by EOS. Scoliosis and kyphosis angles, T1-T12 and T1-S1 length were evaluated preoperatively, postoperatively, and at the last follow-up. A visual analogue scale score was used to evaluate pain during outpatient rod distraction procedures. The mean follow-up is 27 months. All patients attended distractions of the magnetic rod through an external remote control every 3 months. The mean predicted distraction was 3 mm at each lengthening session., Results: The mean Cobb angle value was 64.7±17.4 degrees (range, 45 to 100 degrees) preoperatively and 28.5±13.9 degrees (range, 15 to 59 degrees) at the latest follow-up. The mean T1-S1 length value was 27.1±5.4 cm (range, 16 to 34.8 cm) preoperatively and 32.8±4 cm (range, 26.5 to 39 cm) at the latest follow-up. The mean T1-T12 length value was 16.2±2.7 cm (range, 10 to 19 cm) preoperatively and 20.6±2.9 cm (range, 15.5 to 23.5 cm) at the latest follow-up.The average monthly T1-T12 height increase was 0.8 mm, whereas the average monthly T1-S1 increase was 0.9 mm.Two patients experienced a rod breakage and 1 patient had a pull-out of the apical hooks., Conclusions: Although implant-related complications could occur, as in all EOS growing rods procedures, MCGR can be effectively used in patients with EOS. This spinal instrumentation can overcome many of the complications related with the traditional growing rods implants. This procedure can be effectively used in outpatient settings, minimizing surgical scarring, surgical site infection, and psychological distress due to multiple surgeries needed in the traditional growing rods system, improving quality of life, and saving health care costs., Level of Evidence: Level IV.

Purpose: Adolescent idiopathic scoliosis (AIS) is a tridimensional deformity characterized by coronal and sagittal profiles changes. We present a series of 62 patients affected by AIS and treated by thoracic Universal Clamps and transpedicular lumbar screws hybrid system., Methods: Mean age was 13 years. Average pre-operative Cobb angle was 63° ± 12°. Patients were divided into two groups depending on the kyphosis angle: lower than 45° (51 patients, 82.3 %, mean 21° ± 3°) and higher than 45° (11 patients, 17.7 %, mean 62° ± 6°)., Results: The average percentage of coronal correction was 70 ± 3 % (mean post-operative Cobb angle 19° ± 4°, P < 0.001). In patients with pre-operative physiological thoracic kyphosis-hypokyphosis, we observed an increase in the average value (32° ± 4°, P < 0.001), while in patients with pre-operative hyperkyphosis, mean decrease of thoracic kyphosis was 19° ± 3° (43° ± 4°, P < 0.001)., Conclusions: This case-series study showed the efficacy and safety of Universal Clamp hybrid system in correcting coronal deformity and restoring physiological thoracic kyphosis in patients affected by AIS.

Purpose: Patients affected by cerebral palsy often develop progressive scoliosis that can results in trunk instability with an impairment of both coronal and sagittal balance. The aim of this retrospective study was to demonstrate the ability of UC to control the sagittal profile in a consecutive series of patients affected by neurological scoliosis., Methods: From 2006 to 2008, 84 patients (57 F, 27 M) affected by neurological scoliosis were treated surgically. Mean age was 14 years (range 10-17). The etiology was mainly cerebral palsy. The average pre-operative Cobb angle was 73° ± 16°. Patients were divided into three groups according to the pre-operative presence of: physiological kyphosis (mean 29° ± 8°), thoracic lordosis (mean 10° ± 6°) and hyperkyphosis (51° ± 8°). A posterior access was performed in all patients using thoracic UC associated with transpedicular lumbar screws and a conventional claw at the upper extremity of the construct., Results: The average percentage of coronal correction was 72%. In all three groups, we observed a common trend toward maintaining or restoring the physiological values. Mean follow-up time was 36 months. At the 1-year follow-up, the mean loss of correction was 7° ± 2° in the coronal plane and 2° ± 1° in the sagittal plane with no other change thereafter., Conclusions: The hybrid construct using UC appears effective in neurological scoliosis treatment, providing a good correction of the deformity in both coronal and sagittal planes. In the present series, physiological thoracic kyphosis has been restored in all patients, providing better sitting tolerance in wheelchair-bound patients, and retaining standing and walking abilities in ambulatory patients.