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326 results on '"Ogawa, Yutaka"'

1. Thermal Stress and Nuclear Transport

Author

Kose, Shingo, Ogawa, Yutaka, Imamoto, Naoko, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Rosenhouse-Dantsker, Avia, Editorial Board Member, Tominaga, Makoto, editor, and Takagi, Masahiro, editor

Published
2024
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2. The interaction between the import carrier Hikeshi and HSP70 is modulated by heat, facilitating the nuclear import of HSP70 under heat stress conditions.

Author

Kose, Shingo, Yoshioka, Sakie, Ogawa, Yutaka, Watanabe, Ai, and Imamoto, Naoko

Subjects
NUCLEAR pore complex, NUCLEOCYTOPLASMIC interactions, NUCLEAR transport (Cytology), MOLECULAR chaperones, LOW temperatures
Abstract

Heat stress strongly triggers the nuclear localization of the molecular chaperone HSP70. Hikeshi functions as a unique nuclear import carrier of HSP70. However, how the nuclear import of HSP70 is activated in response to heat stress remains unclear. Here, we investigated the effects of heat on the nuclear import of HSP70. In vitro transport assays revealed that pretreatment of the test samples with heat facilitated the nuclear import of HSP70. Furthermore, binding of Hikeshi to HSP70 increased when temperatures rose. These results indicated that heat is one of the factors that activates the nuclear import of HSP70. Previous studies showed that the F97A mutation in Hikeshi in an extended loop induced an opening in the hydrophobic pocket and facilitated the translocation of Hikeshi through the nuclear pore complex. We found that nuclear accumulation of HSP70 occurred at a lower temperature in cells expressing the Hikeshi‐F97A mutant than in cells expressing wild‐type Hikeshi. Collectively, our results show that the movement of the extended loop may play an important role in the interaction of Hikeshi with both FG (phenylalanine‐glycine)‐nucleoporins and HSP70 in a temperature‐dependent manner, resulting in the activation of nuclear import of HSP70 in response to heat stress. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Functional Reconstruction of Severely Burned Hand With Osseous Blood Flow Deficiency With Immediate Surgery Using an Abdominal Bipediceled Flap: A Case Report

Author

Hihara, Masakatsu, Matsushima, Takashi, Tanaka, Yoshihito, Ogawa, Yutaka, Kakudo, Natsuko, and Kusumoto, Kenji

Subjects
hand burn, finger reconstruction, third-degree burn, Case Report, immediate operation, osseous blood flow deficiency
Abstract

Objective: When hands suffer burns, the tendons and digital bones are rarely injured because of the quick withdrawal reflex away from the heat source. Hence, a consensus of opinion regarding the treatment of severe hand burns with osseous blood flow deficiency has not been reached among clinicians. Methods: The patient was a 28-year-old woman whose fingers were accidentally soaked in heated cooking oil (160°C-170°C) for approximately 1 minute. The result was fourth-degree (extending to the tendon) digital burns of the distal end of the proximal interphalangeal joint with blood flow deficiency to the skin, tendon, and bone. Results: We performed immediate reconstructive surgery using an abdominal bipediceled flap. Two weeks later, after the flap was separated, all fingers showed complete range of motion, restoration of the metacarpophalangeal joint, and a high range (0°-75°) of proximal interphalangeal joint mobility with an acceptable digital length. Conclusions: Our experience shows that immediate surgery is highly preferable for deep burns of the hand to avoid delayed intractable complications and to achieve better and faster results.

Published
2018

26. A case of malignant melanoma with brain metastases successfully treated by whole brain radiation and a gamma knife

Author

Murao Satomi, Kumano Kimiko, Yasuo Kensaku, Hayashi Kazuhiro, Nagae Toshiyuki, Adachi Atsuko, Shimizu Hideki, Murata Yozo, Ogawa Yutaka, and Sarayama Yasuko

Subjects
medicine.medical_specialty, Thesaurus (information retrieval), business.industry, Melanoma, medicine, Whole brain irradiation, Radiology, Gamma knife, business, medicine.disease
Abstract

60歳, 男性。初診の約1年前より右踵部の灰褐色調色素斑に気付くも放置していたところ, びらんと腫瘤が出現し, 2003年3月紹介受診。悪性黒色腫と診断し, 同年5月原発巣切除術, 6月右鼠径部リンパ節郭清を施行したが, 所属リンパ節に転移は認めずpT4bN0M0, stage II Cと診断した。しかし郭清術後不穏状態が出現したため, 頭部MRI施行したところ脳内に多数の転移巣を認めた。7月脳転移巣に対し30Gyの全脳照射を施行後, 転移巣は著明に縮小傾向を示し, 残存する病巣に対し8月, 最大線量50Gy・辺縁線量25Gyにてガンマナイフ治療を追加した。さらにDAC-Tam療法3クール終了後の2004年12月現在, 頭部MRI像で明らかな病巣を認めない。悪性黒色腫の多発脳転移は従来治療抵抗性とされていたが, 自験例では全脳照射とガンマナイフの併用が奏効したため, 放射線照射は試みるべき治療法の一つであると考えた。

Published
2005
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31. Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene

Author

Edvardson, Simon, primary, Kose, Shingo, additional, Jalas, Chaim, additional, Fattal-Valevski, Aviva, additional, Watanabe, Ai, additional, Ogawa, Yutaka, additional, Mamada, Hiroshi, additional, Fedick, Anastasia M, additional, Ben-Shachar, Shay, additional, Treff, Nathan R, additional, Shaag, Avraham, additional, Bale, Sherri, additional, Gärtner, Jutta, additional, Imamoto, Naoko, additional, and Elpeleg, Orly, additional

Published
2015
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32. Development of Irradiation Techniques for Material Study in JMTR

Author

Narui, Minoru, Suzuki, Yoshimitsu, Yamazaki, Masanori, Ogawa, Yutaka, Shikama, Tatsuo, and Kayano, Hideo

Abstract

The Oarai Branch has been carrying out the irradiation of materials using the JMTR, for these twenty years. We have made efforts to improve the irradiation conditions and to satisfy. the various demands evoked by our users. Here, we describe our efforts to improve the irradiation rigs and the irradiation techniques.

Published
1991

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