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2. Relationship between 2nd-generation angiotensin receptor blockers and the risk of hypotension in COVID-19 patients admitted to hospital

Author

Yoshihara, Fumiki, Matsuzawa, Yasushi, Nakatsuka, Kiyomasa, Kirigaya, Jin, Takeuchi, Ichiro, Kimura, Kazuo, Konishi, Masaaki, Tamura, Kouichi, Fukui, Kazuki, Tsukahara, Kengo, Shimizu, Hiroyuki, Iwabuchi, Keisuke, Yamada, Yu, Saka, Kenichiro, Sato, Yukihito, Ogawa, Masahiro, Hayakawa, Kayoko, Ohmagari, Norio, Ikeda, Syuhei, Akao, Masaharu, Shimomura, Hideki, Kihara, Yasuki, Yoshimoto, Akihiro, Morita, Masanori, Kumada, Norihiko, Ogata, Soshiro, Nishimura, Kunihiro, Arisato, Tetsuya, Matsuo, Miki, Kishida, Masatsugu, Yasuda, Satoshi, and Ogawa, Hisao

Published
2024
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5. Clinical outcomes of adjusted-dose versus standard-dose prasugrel in East Asian patients with acute myocardial infarction

Author

Honda, Satoshi, Lee, Sangyeub, Cho, Kyung Hoon, Takegami, Misa, Nishihira, Kensaku, Kojima, Sunao, Asaumi, Yasuhide, Saji, Mike, Yamashita, Jun, Hibi, Kiyoshi, Takahashi, Jun, Sakata, Yasuhiko, Takayama, Morimasa, Sumiyoshi, Tetsuya, Ogawa, Hisao, Kimura, Kazuo, Sim, Doo Sun, Kim, Hyun Kuk, Kim, Weon, Ahn, Youngkeun, Jeong, Myung Ho, and Yasuda, Satoshi

Published
2024
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6. C-reactive Protein Levels and Cardiovascular Outcomes After Febuxostat Treatment in Patients with Asymptomatic Hyperuricemia: Post-hoc Analysis of a Randomized Controlled Study

Author

Kojima, Sunao, Uchiyama, Kazuaki, Yokota, Naoto, Tokutake, Eiichi, Wakasa, Yutaka, Hiramitsu, Shinya, Waki, Masako, Jinnouchi, Hideaki, Kakuda, Hirokazu, Hayashi, Takahiro, Kawai, Naoki, Sugawara, Masahiro, Mori, Hisao, Tsujita, Kenichi, Matsui, Kunihiko, Hisatome, Ichiro, Ohya, Yusuke, Kimura, Kazuo, Saito, Yoshihiko, and Ogawa, Hisao

Published
2023
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8. Serum mature and furin-cleaved proprotein convertase subtilisin/kexin type 9 levels and their association with cardiovascular events in statin-treated patients with cardiovascular disease

Author

Hibi, Kiyoshi, Gohbara, Masaomi, Uemura, Kohei, Iwahashi, Noriaki, Okada, Kozo, Iwata, Hiroshi, Fukumoto, Yoshihiro, Hiro, Takafumi, Ozaki, Yukio, Iimuro, Satoshi, Sakuma, Ichiro, Hokimoto, Seiji, Miyauchi, Katsumi, Matsuyama, Yutaka, Nakagawa, Yoshihisa, Ogawa, Hisao, Daida, Hiroyuki, Shimokawa, Hiroaki, Saito, Yasushi, Kimura, Takeshi, Matsuzaki, Masunori, Kimura, Kazuo, and Nagai, Ryozo

Published
2024
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9. JCS/CVIT/JCC 2023 guideline focused update on diagnosis and treatment of vasospastic angina (coronary spastic angina) and coronary microvascular dysfunction

Author

Hokimoto, Seiji, Kaikita, Koichi, Yasuda, Satoshi, Tsujita, Kenichi, Ishihara, Masaharu, Matoba, Tetsuya, Matsuzawa, Yasushi, Mitsutake, Yoshiaki, Mitani, Yoshihide, Murohara, Toyoaki, Noda, Takashi, Node, Koichi, Noguchi, Teruo, Suzuki, Hiroshi, Takahashi, Jun, Tanabe, Yasuhiko, Tanaka, Atsushi, Tanaka, Nobuhiro, Teragawa, Hiroki, Yasu, Takanori, Yoshimura, Michihiro, Asaumi, Yasuhide, Godo, Shigeo, Ikenaga, Hiroki, Imanaka, Takahiro, Ishibashi, Kohei, Ishii, Masanobu, Ishihara, Takayuki, Matsuura, Yunosuke, Miura, Hiroyuki, Nakano, Yasuhiro, Ogawa, Takayuki, Shiroto, Takashi, Soejima, Hirofumi, Takagi, Ryu, Tanaka, Akihito, Taruya, Akira, Tsuda, Etsuko, Wakabayashi, Kohei, Yokoi, Kensuke, Minamino, Toru, Nakagawa, Yoshihisa, Sueda, Shozo, Shimokawa, Hiroaki, and Ogawa, Hisao

Published
2023
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11. Abstract 12839: Anti-Thrombotic Therapy, Bleeding, and Mortality in Patients With Acute Myocardial Infarction and a History of Cancer: A Report From JAMIR, the Multi-Center, Nationwide Prospective Registry

Author

Adachi, Ayumi, Oyama, Kazuma, Takahashi, Jun, Honda, Satoshi, Kensaku, Nishihira, Kojima, Sunao, Takegami, Misa, Asaumi, Yasuhide, Yamashita, Jun, Saji, Mike, Hibi, Kiyoshi, Sakata, Yasuhiko, Takayama, Morimasa, Sumiyoshi, Tetsuya, Ogawa, Hisao, Kimura, Kazuo, and Yasuda, Satoshi

Published
2023
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16. Modifiers of the Risk of Diabetes for Long-Term Outcomes After Coronary Revascularization: CREDO-Kyoto PCI/CABG Registry

Author

Kimura, Takeshi, Shiomi, Hiroki, Matsuda, Mitsuo, Takeuchi, Yuzo, Mitsuoka, Hirokazu, Uegaito, Takashi, Nakagawa, Yoshihisa, Tamura, Toshihiro, Konishi, Takashi, Ootani, Seiji, Fujiwara, Hisayoshi, Takatsu, Yoshiki, Sato, Yukihito, Taniguchi, Ryoji, Kataoka, Kazuaki, Inoko, Moriaki, Nohara, Ryuji, Nakano, Kimisato, Miyamoto, Syoichi, Kunihiko, Nagai, Murakami, Tomoyuki, Takeda, Teruki, Ishida, Katsuya, Nobuyoshi, Masakiyo, Yamaji, Kyohei, Yasumoto, Hitoshi, Iwabuchi, Masashi, Ando, Kenji, Domei, Takenori, Kato, Masayuki, Tatami, Ryozo, Shirotani, Manabu, Hattori, Ryuichi, Kita, Toru, Furukawa, Yutaka, Ehara, Natsuhiko, Kihara, Yasuki, Eizawa, Hiroshi, Kato, Hiroshi, Ishii, Katsuhisa, Aoyama, Takeshi, Sakurai, Takahiro, Kawanami, Masaki, Suyama, Tamaki, Tada, Eiji, Tanaka, Masaru, Inada, Tsukasa, Uzui, Hiroyasu, Nakano, Akira, Lee, Jong-Dae, Onodera, Tomoya, Takizawa, Akinori, Ryuzo, Nawada, Shinoda, Eiji, Takahashi, Masaaki, Yamada, Miho, Horie, Minoru, Yamamoto, Takashi, Takashima, Hiroyuki, Sakai, Hiroshi, Tamura, Takashi, Toyofuku, Mamoru, Kotoura, Hajime, Miura, Akira, Takahashi, Mamoru, Matoba, Yoshiki, Takumi, Takuro, Tei, Chuwa, Hamasaki, Shuichi, Doi, Osamu, Kambara, Hirofumi, Kaburagi, Satoshi, Sakamoto, Hiroki, Tada, Tomohisa, Mitsudo, Kazuaki, Kadota, Kazushige, Tada, Takeshi, Miki, Shinji, Mizoguchi, Tetsu, Akira, Yoshida, Kaneda, Kazuhisa, Ogawa, Hisao, Sugamura, Koichi, Sugiyama, Seigo, Doyama, Kiyoshi, Araki, Makoto, Suwa, Satoru, Sakata, Ryuzo, Ikeda, Tadashi, Marui, Akira, Minatoya, Kenji, Yamazaki, Kazuhiro, Onoe, Masahiko, Ogawa, Tatsuya, Yamanaka, Kazuo, Iwakura, Atsushi, Ohno, Nobuhisa, Fujiwara, Keiichi, Hanyu, Michiya, Soga, Kinji, Matsushita, Tsutomu, Nishiwaki, Noboru, Yoshida, Yuichi, Tamura, Nobushige, Okada, Yukikatsu, Nasu, Michihiro, Koyama, Tadaaki, Nakayama, Shogo, Tanaka, Kuniyoshi, Koshiji, Takaaki, Morioka, Koichi, Shimamoto, Mitsuomi, Yamazaki, Fumio, Terai, Yasuhiko, Nishizawa, Junichiro, Aota, Masaki, Kanemitsu, Naoki, Hara, Hiroyuki, Tabata, Takafumi, Imoto, Yutaka, Yamamoto, Hiroyuki, Matsuda, Katsuhiko, Nara, Masafumi, Tsuneyoshi, Hiroshi, Komiya, Tatsuhiko, Nakajima, Hiroyuki, Esaki, Jiro, Kawasuji, Michio, Moriyama, Syuji, Tambara, Keiichi, Arimura, Sakiko, Fujino, Yumika, Hanazawa, Miya, Hibi, Chikako, Kato, Risa, Kinoshita, Yui, Kitagawa, Kumiko, Kitamura, Masayo, Kuwahara, Takahiro, Sachiko, Maeda, Miki, Izumi, Minematsu, Saeko, Nishida, Satoko, Okamoto, Naoko, Saeki, Asuka, Sasae, Hitomi, Sato, Yuki, Takahashi, Asuka, Takinami, Emi, Tezuka, Saori, Tsuda, Marina, Tsumori, Miyuki, Uchida, Yuriko, Yamamoto, Yuko, Yamauchi, Misato, Yamazaki, Itsuki, Yoshimoto, Mai, Abe, Mitsuru, Fuki, Masayuki, Hayano, Mamoru, Kato, Eri, Kato, Yoshihiro, Matsumura-Nakano, Yukiko, Nakajima, Tetsu, Nakatsuma, Kenji, Natsuaki, Masahiro, Takeji, Yasuaki, Tazaki, Junichi, Tokushige, Akihiro, Watanabe, Hiroki, Yaku, Hidenori, Yamamoto, Erika, Yamamoto, Ko, Yamashita, Yugo, Yoshikawa, Yusuke, Morimoto, Takeshi, Kato, Eri T., Imada, Kazuaki, Nishikawa, Ryusuke, Mabuchi, Hiroshi, and Soga, Yoshiharu

Published
2022
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18. Optimal target of LDL cholesterol level for statin treatment: challenges to monotonic relationship with cardiovascular events

Author

Sakuma, Masashi, Iimuro, Satoshi, Shinozaki, Tomohiro, Kimura, Takeshi, Nakagawa, Yoshihisa, Ozaki, Yukio, Iwata, Hiroshi, Miyauchi, Katsumi, Daida, Hiroyuki, Suwa, Satoru, Sakuma, Ichiro, Nishihata, Yosuke, Saito, Yasushi, Ogawa, Hisao, Matsuzaki, Masunori, Ohashi, Yasuo, Taguchi, Isao, Toyoda, Shigeru, Inoue, Teruo, and Nagai, Ryozo

Published
2022
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19. Prognostic impact of heart failure admission in survivors of acute myocardial infarction.

Author

Takeuchi, Satoshi, Honda, Satoshi, Nishihira, Kensaku, Kojima, Sunao, Takegami, Misa, Asaumi, Yasuhide, Saji, Mike, Yamashita, Jun, Hibi, Kiyoshi, Takahashi, Jun, Sakata, Yasuhiko, Takayama, Morimasa, Sumiyoshi, Tetsuya, Ogawa, Hisao, Kimura, Kazuo, and Yasuda, Satoshi

Subjects
MAJOR adverse cardiovascular events, PERCUTANEOUS coronary intervention, HEART failure, CEREBRAL infarction, HEART failure patients, VENTRICULAR ejection fraction, MYOCARDIAL infarction
Abstract

Aims: The incidence and prognosis of symptomatic heart failure following acute myocardial infarction (AMI) in the primary percutaneous coronary intervention era have rarely been reported in the literature. This study aimed to (i) determine the incidence of heart failure admission among AMI survivors, (ii) compare 1 year outcomes between patients with heart failure admission and those without, and (iii) identify the independent risk factors associated with heart failure admission. Methods and results: The Japan Acute Myocardial Infarction Registry is a prospective multicentre registry from which data on consecutively enrolled patients with AMI from 50 institutions between 2015 and 2017 were obtained. Among the 3411 patients enrolled, 3226 who survived until discharge were included in this study. The primary endpoint was all‐cause mortality. The secondary endpoints were major adverse cardiovascular events (defined as cardiovascular mortality, non‐fatal myocardial infarction, or non‐fatal cerebral infarction) and major bleeding events corresponding to Bleeding Academic Research Consortium Type 3 or 5. Clinical outcomes were compared between the patients who were and were not admitted for heart failure. Over a median follow‐up of 12 months, 124 patients (3.8%) were admitted due to heart failure. Independent risk factors for heart failure admission included older age, female sex, Killip class ≥2 on admission, left ventricular ejection fraction <40%, estimated glomerular filtration rate ≤30 mL/min/1.73 m2, a history of malignancy, and non‐use of angiotensin‐converting enzyme inhibitors at discharge. The cumulative incidence of all‐cause mortality was significantly higher in the heart failure admission group than in the no heart failure admission group (11.3% vs. 2.5%, P < 0.001). The rates of major adverse cardiovascular events (16.9% vs. 2.7%, P < 0.001) and major bleeding (6.5% vs. 1.6%, P < 0.001) were significantly higher in the heart failure admission group. Heart failure admission was associated with a higher risk of all‐cause mortality, even after adjusting for potential confounders (adjusted hazard ratio: 2.41, 95% confidence interval: 1.33–4.39, P = 0.004). Conclusions: Utilizing real‐world data of the contemporary percutaneous coronary intervention era from the Japan Acute Myocardial Infarction Registry database, this study demonstrates that the heart failure admission of AMI survivors was significantly associated with higher all‐cause mortality rates. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Antithrombotic therapy for stable coronary artery disease and atrial fibrillation in patients with and without revascularisation: the AFIRE trial

Author

Noda, Takashi, primary, Nochioka, Kotaro, additional, Kaikita, Koichi, additional, Akao, Masaharu, additional, Ako, Junya, additional, Matoba, Tetsuya, additional, Nakamura, Masato, additional, Miyauchi, Katsumi, additional, Hagiwara, Nobuhisa, additional, Kimura, Kazuo, additional, Hirayama, Atsushi, additional, Matsui, Kunihiko, additional, Ogawa, Hisao, additional, Yasuda, Satoshi, additional, and AFIRE investigators, on behalf of the, additional

Published
2024
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21. Relation of renal function to mid-term prognosis of stable angina patients with high- or low-dose pitavastatin treatment: REAL-CAD substudy

Author

Abe, Mitsuru, Ozaki, Yukio, Takahashi, Hiroshi, Ishii, Mitsuru, Masunaga, Nobutoyo, Ismail, Tevfik F., Iimuro, Satoshi, Fujita, Retsu, Iwata, Hiroshi, Sakuma, Ichiro, Nakagawa, Yoshihisa, Hibi, Kiyoshi, Hiro, Takafumi, Fukumoto, Yoshihiro, Hokimoto, Seiji, Miyauchi, Katsumi, Ogawa, Hisao, Daida, Hiroyuki, Shimokawa, Hiroaki, Saito, Yasushi, Matsuzaki, Masunori, Akao, Masaharu, Kimura, Takeshi, and Nagai, Ryozo

Published
2021
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24. Impact of Age on Gender Difference in Long-term Outcome of Patients With Acute Myocardial Infarction (from J-MINUET)

Author

Kimura, Toshio, Akahori, Hirokuni, Asakura, Masanori, Nakao, Koichi, Ozaki, Yukio, Kimura, Kazuo, Ako, Junya, Noguchi, Teruo, Suwa, Satoru, Fujimoto, Kazuteru, Nakama, Yasuharu, Morita, Takashi, Shimizu, Wataru, Saito, Yoshihiko, Hirohata, Atsushi, Morita, Yasuhiro, Inoue, Teruo, Okamura, Atsunori, Mano, Toshiaki, Wake, Minoru, Tanabe, Kengo, Shibata, Yoshisato, Owa, Mafumi, Tsujita, Kenichi, Funayama, Hiroshi, Kokubu, Nobuaki, Kozuma, Ken, Uemura, Shiro, Toubara, Tetsuya, Saku, Keijiro, Oshima, Shigeru, Nishimura, Kunihiro, Miyamoto, Yoshihiro, Ogawa, Hisao, and Ishihara, Masaharu

Published
2021
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25. A Pilot Study: The Beneficial Effects of Combined Statin-exercise Therapy on Cognitive Function in Patients with Coronary Artery Disease and Mild Cognitive Decline

Author

Toyama, Kensuke, Sugiyama, Seigo, Oka, Hideki, Hamada, Mari, Iwasaki, Yuri, Horio, Eiji, Rokutanda, Taku, Nakamura, Shinichi, Spin, Joshua M, Tsao, Philip S, and Ogawa, Hisao

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Heart Disease, Neurodegenerative, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Cardiovascular, Brain Disorders, Alzheimer's Disease, Clinical Research, Atherosclerosis, Heart Disease - Coronary Heart Disease, Clinical Trials and Supportive Activities, Aging, Acquired Cognitive Impairment, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Age Factors, Aged, Aged, 80 and over, Body Mass Index, Cognitive Dysfunction, Coronary Artery Disease, Exercise Therapy, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Lipids, Male, Middle Aged, Neuropsychological Tests, Odds Ratio, Physical Fitness, Pilot Projects, Risk Factors, Sex Factors, statins, exercise, cognition, coronary artery disease, Public Health and Health Services, General & Internal Medicine, Clinical sciences
Abstract

Objective Hypercholesterolemia, a risk factor in cognitive impairment, can be treated with statins. However, cognitive decline associated with "statins" (HMG-CoA reductase inhibitors) is a clinical concern. This pilot study investigated the effects of combining statins and regular exercise on cognitive function in coronary artery disease (CAD) patients with prior mild cognitive decline. Methods We recruited 43 consecutive CAD patients with mild cognitive decline. These patients were treated with a statin and weekly in-hospital aerobic exercise for 5 months. We measured serum lipids, exercise capacity, and cognitive function using the mini mental state examination (MMSE). Results Low-density lipoprotein cholesterol levels were significantly decreased, and maximum exercise capacity (workload) was significantly increased in patients with CAD and mild cognitive decline after treatment compared with before. Combined statin-exercise therapy significantly increased the median (range) MMSE score from 24 (22-25) to 25 (23-27) across the cohort (p65 years, sex, and presence of diabetes mellitus, a decrease in BMI during statin-exercise therapy was significantly correlated with an increase in the MMSE score (odds ratio: 4.57, 95% confidence interval: 1.05-20.0; p

Published
2017

26. Characteristics, Antithrombotic Patterns, and Prognostic Outcomes in Claudication and Critical Limb-Threatening Ischemia Undergoing Endovascular Therapy

Author

Kawarada, Osami, Zen, Kan, Hozawa, Koji, Obara, Hideaki, Matsubara, Kentaro, Yamamoto, Yoshito, Doijiri, Tatsuki, Tamai, Nozomu, Ito, Shigenori, Higashimori, Akihiro, Kawasaki, Daizo, Doi, Hideki, Matsushita, Kensuke, Tsukahara, Kengo, Noda, Katsuo, Shimpo, Masahisa, Tsuda, Yuki, Sonoda, Shinjo, Taniguchi, Takuya, Waseda, Katsuhisa, Munehisa, Masato, Taguchi, Eiji, Kinjo, Tatsuya, Sasaki, Yohei, Yuba, Kenichiro, Yamaguchi, Shinichiro, Nakagami, Takuo, Ayabe, Shinobu, Sakamoto, Shingo, Yagyu, Takeshi, Ogata, Soshiro, Nishimura, Kunihiro, Motomura, Hisashi, Noguchi, Teruo, Ishihara, Masaharu, Ogawa, Hisao, and Yasuda, Satoshi

Abstract

Purpose: The underlying difference between intermittent claudication (IC) and critical limb-threatening ischemia (CLTI) still remains unclear. This prospective multicenter observational study aimed to clarify differences in clinical features and prognostic outcomes between IC and CLTI, and prognostic factors in patients undergoing endovascular therapy (EVT).Materials and Methods: A total of 692 patients with 808 limbs were enrolled from 20 institutions in Japan. The primary measurements were the 3-year rates of major adverse cardiovascular event (MACE) and reintervention.Results: Among patients, 79.0% had IC and 21.0% had CLTI. Patients with CLTI were more frequently women and more likely to have impaired functional status, undernutrition, comorbidities, hypercoagulation, hyperinflammation, distal artery disease, short single antiplatelet and long anticoagulation therapies, and late cilostazol than patients with IC. Aortoiliac and femoropopliteal diseases were dominant in patients with IC and infrapopliteal disease was dominant in patients with CLTI. Patients with CLTI underwent less frequently aortoiliac intervention and more frequently infrapopliteal intervention than patients with IC. Longitudinal change of ankle-brachial index (ABI) exhibited different patterns between IC and CLTI (pinteraction=0.002), but ABI improved after EVT both in IC and in CLTI (p<0.001), which was sustained over time. Dorsal and plantar skin perfusion pressure in CLTI showed a similar improvement pattern (pinteraction=0.181). Distribution of Rutherford category improved both in IC and in CLTI (each p<0.001). Three-year MACE rates were 20.4% and 42.3% and 3-year reintervention rates were 22.1% and 46.8% for patients with IC and CLTI, respectively (log-rank p<0.001). Elevated D-dimer (p=0.001), age (p=0.043), impaired functional status (p=0.018), and end-stage renal disease (p=0.019) were independently associated with MACE. After considering competing risks of death and major amputation for reintervention, elevated erythrocyte sedimentation rate (p=0.003) and infrainguinal intervention (p=0.002) were independently associated with reintervention. Patients with CLTI merely showed borderline significance for MACE (adjusted hazard ratio 1.700, 95% confidence interval 0.950–3.042, p=0.074) and reintervention (adjusted hazard ratio 1.976, 95% confidence interval 0.999–3.909, p=0.05).Conclusions: The CLTI is characterized not only by more systemic comorbidities and distal disease but also by more inflammatory coagulation disorder compared with IC. Also, CLTI has approximately twice MACE and reintervention rates than IC, and the underlying inflammatory coagulation disorder per se is associated with these outcomes.Clinical Impact The underlying difference between intermittent claudication (IC) and critical limb-threatening ischemia (CLTI) still remains unclear. This prospective multicenter observational study, JPASSION study found that CLTI was characterized not only by more systemic comorbidities and distal disease but also by more inflammatory coagulation disorder compared to IC. Also, CLTI had approximately twice major adverse cardiovascular event (MACE) and reintervention rates than IC. Intriguingly, the underlying inflammatory coagulation disorder per se was independently associated with MACE and reintervention. Further studies to clarify the role of anticoagulation and anti-inflammatory therapies will contribute to the development of post-interventional therapeutics in the context of peripheral artery disease.

Published
2024
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28. Impacts of Febuxostat on Cerebral and Cardiovascular Events in Elderly Patients with Hyperuricemia: Post Hoc Analysis of a Randomized Controlled Trial.

Author

Sugawara, Masahiro, Kojima, Sunao, Hisatome, Ichiro, Matsui, Kunihiko, Uchiyama, Kazuaki, Yokota, Naoto, Tokutake, Eiichi, Wakasa, Yutaka, Hiramitsu, Shinya, Waki, Masako, Jinnouchi, Hideaki, Kakuda, Hirokazu, Hayashi, Takahiro, Kawai, Naoki, Mori, Hisao, Tsujita, Kenichi, Ohya, Yusuke, Kimura, Kazuo, Saito, Yoshihiko, and Ogawa, Hisao

Subjects
OLDER patients, FEBUXOSTAT, RANDOMIZED controlled trials, HYPERURICEMIA, AGE groups, CEREBRAL malaria
Abstract

A recent meta‐analysis found no benefit of uric acid‐lowering therapy including febuxostat on death, cardiovascular events, or renal impairment. However, there may be populations that benefit from febuxostat in reducing mortality and cerebral and cardiovascular events. The aim of the present study was to examine the clinical benefit of febuxostat in elderly patients stratified by age using Febuxostat for Cerebral and CaRdiorenovascular Events PrEvEntion StuDy (FREED) data. FREED was a randomized study involving patients aged 65 years or older with hyperuricemia and risk factors for cerebral, cardiovascular, or renal diseases. A total of 1,070 patients were included in this post hoc analysis, divided into 2 age groups: 65–74 years and ≥ 75 years. Patients were randomized into febuxostat and non‐febuxostat groups, with uric acid levels monitored for 36 months. The primary composite end point included cerebral, cardiovascular, and renal events. In patients aged between 65 and 74 years, febuxostat significantly reduced the risk of future cerebral and cardiorenovascular events. However, no effects of febuxostat were found in the older population aged ≥ 75 years. Heterogeneity in potential interactions between the age and febuxostat treatment was particularly observed in non‐fatal cerebral and cardiovascular events and all‐cause death. Patients aged ≥ 75 years exhibited more pre‐existing factors associated with cerebral and cardiorenovascular events than those aged 65–74 years. The effectiveness of febuxostat varies by age group, with potential benefits for patients aged 65–74 years. The effects of febuxostat are complex and it is important to consider patient characteristics in its clinical use. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Clinical Outcomes of Adjusted-Dose Versus Standard-Dose Prasugrel in East Asian Patients with Acute Myocardial Infarction

Author

Honda, Satoshi, primary, Lee, Sang Yeub, additional, Cho, Kyung Hoon, additional, Takegami, Misa, additional, Nishihira, Kensaku, additional, Kojima, Sunao, additional, Asaumi, Yasuhide, additional, Saji, Mike, additional, Yamashita, Jun, additional, Hibi, Kiyoshi, additional, Takahashi, Jun, additional, Sakata, Yasuhiko, additional, Takayama, Morimasa, additional, Sumiyoshi, Tetsuya, additional, Ogawa, Hisao, additional, Kimura, Kazuo, additional, Sim, Doo Sun, additional, Kim, Hyun Kuk, additional, Kim, Weon, additional, Ahn, Youngkeun, additional, Jeong, Myung Ho, additional, and Yasuda, Satoshi, additional

Published
2024
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36. Residual vascular risk in diabetes – Will the SPPARM alpha concept hold the key?

Author

Fruchart, Jean-Charles, Santos, Raul D., Yamashita, Shizuya, Aikawa, Masanori, Libby, Peter, Plutzky, Jorge, Pradhan, Aruna, Ridker, Paul, Aguilar-Salinas, Carlos, Al Rasadi, Khalid, Amarenco, Pierre, Barter, Philip J., Ceska, Richard, Corsini, Alberto, Ruscica, Massimiliano, Després, Jean-Pierre, Duriez, Patrick, Eckel, Robert H., Ezhov, Marat V., Farnier, Michel, Ginsberg, Henry N., Hermans, Michel P., Ishibashi, Shun, Karpe, Fredrik, Kodama, Tatsuhiko, Koenig, Wolfgang, Krempf, Michel, Lim, Soo, Lorenzatti, Alberto J., McPherson, Ruth, Nuñez-Cortes, Jesus Millan, Nordestgaard, Børge G., Ogawa, Hisao, Packard, Chris J., Ponte-Negretti, Carlos I., Reiner, Željko, Sadikot, Shaukat, Shimano, Hitoshi, Sritara, Piyamitr, Stock, Jane K., Su, Ta-Chen, Susekov, Andrey V., Tartar, André, Taskinen, Marja-Riitta, Tenenbaum, Alexander, Tokgözoğlu, Lale S., Tomlinson, Brian, Tybjærg-Hansen, Anne, Valensi, Paul, Vrablík, Michal, Wahli, Walter, Watts, Gerald F., Yokote, Koutaro, and Zambon, Alberto

Published
2019
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41. Impact of Chronic Kidney Disease on Outcomes After Percutaneous Coronary Intervention for Chronic Total Occlusions (from the Japanese Multicenter Registry)

Author

Naganuma, Toru, Tsujita, Kenichi, Mitomo, Satoru, Ishiguro, Hisaaki, Basavarajaiah, Sandeep, Sato, Katsumasa, Kobayashi, Tsuyoshi, Obata, Junei, Nagamatsu, Suguru, Yamanaga, Kenshi, Komura, Naohiro, Sakamoto, Kenji, Yamamoto, Eiichiro, Izumiya, Yasuhiro, Kojima, Sunao, Kaikita, Koichi, Ogawa, Hisao, and Nakamura, Sunao

Published
2018
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44. Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial

Author

Ridker, Paul M, MacFadyen, Jean G, Everett, Brendan M, Libby, Peter, Thuren, Tom, Glynn, Robert J, Kastelein, John, Koenig, Wolfgang, Genest, Jacques, Lorenzatti, Alberto, Varigos, John, Siostrzonek, Peter, Sinnaeve, Peter, Fonseca, Francisco, Nicolau, Jose, Gotcheva, Nina, Yong, Huo, Urina-Triana, Miguel, Milicic, Davor, Cifkova, Renata, Vettus, Riina, Anker, Stephan D, Manolis, Athanasios J, Wyss, Fernando, Forster, Tamas, Sigurdsson, Axel, Pais, Prem, Fucili, Alessandro, Ogawa, Hisao, Shimokawa, Hiroaki, Veze, Irina, Petrauskiene, Birute, Salvador, Leon, Cornel, Jan Hein, Klemsdal, Tor Ole, Medina, Felix, Budaj, Andrzej, Vida-Simiti, Luminita, Kobalava, Zhanna, Otasevic, Petar, Pella, Daniel, Lainscak, Mitja, Seung, Ki-Bae, Commerford, Patrick, Dellborg, Mikael, Donath, Marc, Hwang, Juey-Jen, Kultursay, Hakan, Flather, Marcus, Ballantyne, Christie, Bilazarian, Seth, Chang, William, East, Cara, Forgosh, Les, Harris, Barry, and Ligueros, Monica

Published
2018
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48. Risk prediction score for clinical outcome in atrial fibrillation and stable coronary artery disease

Author

Ishii, Masanobu, primary, Kaikita, Koichi, additional, Yasuda, Satoshi, additional, Akao, Masaharu, additional, Ako, Junya, additional, Matoba, Tetsuya, additional, Nakamura, Masato, additional, Miyauchi, Katsumi, additional, Hagiwara, Nobuhisa, additional, Kimura, Kazuo, additional, Hirayama, Atsushi, additional, Nishihara, Eiichiro, additional, Nakamura, Shinichiro, additional, Matsui, Kunihiko, additional, Ogawa, Hisao, additional, and Tsujita, Kenichi, additional

Published
2023
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50. Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

Author

Ridker, Paul, Lorenzatti, Alberto, Krum, Henry, Varigos, John, Siostrzonek, Peter, Sinnaeve, Peter, Fonseca, Francisco, Nicolau, Jose, Gotcheva, Nina, Genest, Jacques, Yong, Huo, Urina-Triana, Miguel, Milicic, Davor, Cifkova, Renata, Vettus, Riina, Koenig, Wolfgang, Anker, Stephan D, Manolis, Athanasios J, Wyss, Fernando, Forster, Tamas, Sigurdsson, Axel, Pais, Prem, Fucili, Alessandro, Ogawa, Hisao, Shimokawa, Hiroaki, Veze, Irina, Petrauskiene, Birute, Salvador, Leon, Kastelein, John, Cornel, Jan Hein, Klemsdal, Tor Ole, Medina, Felix, Budaj, Andrzej, Vida-Simiti, Luminita, Kobalava, Zhanna, Otasevic, Petar, Pella, Daniel, Lainscak, Mitja, Seung, Ki-Bae, Commerford, Patrick, Dellborg, Mikael, Donath, Marc, Hwang, Juey-Jen, Kultursay, Hakan, Flather, Marcus, Ballantyne, Christie, Bilazarian, Seth, Chang, William, East, Cara, Everett, Brendan, Forgosh, Les, Glynn, Robert, Harris, Barry, Libby, Peter, Ligueros, Monica, Thuren, Tom, Bohula, Erin, Charmarthi, Bindu, Cheng, Susan, Chou, Sherry, Danik, Jacqueline, McMahon, Graham, Maron, Bradley, Ning, MingMing, Olenchock, Benjamin, Pande, Reena, Perlstein, Todd, Pradhan, Aruna, Rost, Natalia, Singhal, Aneesh, Taqueti, Viviany, Wei, Nancy, Burris, Howard, Cioffi, Angela, Dalseg, Anne Marie, Ghosh, Nilanjan, Gralow, Julie, Mayer, Tina, Rugo, Hope, Fowler, Vance, Limaye, Ajit P, Cosgrove, Sara, Levine, Donald, Lopes, Renato, Scott, John, Hilkert, Robert, Tamesby, Georgia, Mickel, Carolyn, Manning, Brian, Woelcke, Julian, Tan, Monique, Manfreda, Sheryl, Ponce, Tom, Kam, Jane, Saini, Ravinder, Banker, Kehur, Salko, Thomas, Nandy, Panjat, Tawfik, Ronda, O'Neil, Greg, Manne, Shobha, Jirvankar, Pravin, Lal, Shankar, Nema, Deepak, Jose, Jaison, Collins, Rory, Bailey, Kent, Blumenthal, Roger, Colhoun, Helen, Gersh, Bernard, Glynn, Robert J, Ridker, Paul M, MacFadyen, Jean G, and Everett, Brendan M

Published
2017
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