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236 results on '"Ogata, Kentaro"'

8. Nephrotoxicity in children with frequently relapsing nephrotic syndrome receiving long-term cyclosporine treatment

Author

Hamasaki, Yuko, Komaki, Fumiyo, Ishikura, Kenji, Hamada, Riku, Sakai, Tomoyuki, Hataya, Hiroshi, and Ogata, Kentaro

Subjects
Nephrotic syndrome -- Drug therapy -- Patient outcomes -- Research, Drug toxicity -- Risk factors, Cyclosporins -- Dosage and administration -- Complications and side effects, Health
Abstract

Background Steroid-sparing drugs, such as cyclosporine, are recommended as treatment for children with frequently relapsing nephrotic syndrome (FRNS) and steroid-related toxicities. We recently reported a high rate of relapsing nephrotic syndrome 2 years after discontinuation of cyclosporine treatment, suggesting that long-term treatment is necessary. Cyclosporine-associated nephrotoxicity (CAN) is a potential side effect of long-term cyclosporine treatment. Methods We retrospectively reviewed pediatric patients with FRNS treated with cyclosporine for [greater than or equal to]3 years at a single center between 1999 and 2012. The cyclosporine dose was adjusted to maintain the whole-blood cyclosporine trough level at 80-100 ng/ml for 6 months, at 60-80 ng/ml for 18 months, and then at around 50-60 ng/ml thereafter. Maintenance dose of prednisolone was not prescribed. CAN was graded in terms of arteriolar hyalinosis and the degree of interstitial fibrosis. Results Thirty-six children (28 males) were enrolled in the study. The median age at the start of long-term cyclosporine treatment was 9.4 years. The median duration of the longest period of cyclosporine treatment was 4.5 years. Most CAN cases were characterized by arteriolar hyalinosis. The frequency of CAN was positively correlated with the duration of cyclosporine treatment, with an odds ratio (95% confidence interval) for CAN of 3.84 (0.79-18.74) after 2-5 years and 6.60 (1.18-36.94) after >5 years of cyclosporine treatment (vs. 0-2 years). Conclusions Although the frequency of CAN was correlated with the duration of cyclosporine treatment in our pediatric patient population, most cases of CAN involved arteriolar hyalinosis. We conclude that long-term cyclosporine treatment is useful for treating FRNS in children, providing its dose is controlled and kidney biopsies are regularly performed., Author(s): Yuko Hamasaki [sup.1] [sup.2] , Fumiyo Komaki [sup.3] , Kenji Ishikura [sup.2] [sup.4] , Riku Hamada [sup.2] , Tomoyuki Sakai [sup.5] , Hiroshi Hataya [sup.2] , Kentaro Ogata [sup.6] [...]

Published
2017
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17. Large magnetocapacitance beyond 420% in epitaxial magnetic tunnel junctions with an MgAl2O4 barrier.

Author

Sato, Kenta, Sukegawa, Hiroaki, Ogata, Kentaro, Xiao, Gang, and Kaiju, Hideo

Subjects
MAGNETIC tunnelling, DRIFT diffusion models, QUANTUM tunneling, SPIN polarization, MULTIFERROIC materials, NUCLEAR spin, ELECTRIC capacity, ELECTRON tunneling
Abstract

Magnetocapacitance (MC) effect has been observed in systems where both symmetries of time-reversal and space-inversion are broken, for examples, in multiferroic materials and spintronic devices. The effect has received increasing attention due to its interesting physics and the prospect of applications. Recently, a large tunnel magnetocapacitance (TMC) of 332% at room temperature was reported using MgO-based (001)-textured magnetic tunnel junctions (MTJs). Here, we report further enhancement in TMC beyond 420% at room temperature using epitaxial MTJs with an MgAl2O4(001) barrier with a cation-disordered spinel structure. This large TMC is partially caused by the high effective tunneling spin polarization, resulted from the excellent lattice matching between the Fe electrodes and the MgAl2O4 barrier. The epitaxial nature of this MTJ system sports an enhanced spin-dependent coherent tunneling effect. Among other factors leading to the large TMC are the appearance of the spin capacitance, the large barrier height, and the suppression of spin flipping through the MgAl2O4 barrier. We explain the observed TMC by the Debye-Fröhlich modelled calculation incorporating Zhang-sigmoid formula, parabolic barrier approximation, and spin-dependent drift diffusion model. Furthermore, we predict a 1000% TMC in MTJs with a spin polarization of 0.8. These experimental and theoretical findings provide a deeper understanding on the intrinsic mechanism of the TMC effect. New applications based on large TMC may become possible in spintronics, such as multi-value memories, spin logic devices, magnetic sensors, and neuromorphic computing. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Influence of Empirical Therapy Utilizing Vancomycin in Patients with Suspected Bacterial Meningitis: A Single-Center Retrospective Study

Author

Nakano, Takafumi, primary, Mizuno, Yasuko, additional, Kawahira, Tomomi, additional, Ueda, Yutaka, additional, Ikeuchi, Tadahiro, additional, Kaneshige, Susumu, additional, Ogata, Kentaro, additional, Hayashi, Toshinobu, additional, Takata, Tohru, additional, Kamimura, Hidetoshi, additional, and Egawa, Takashi, additional

Published
2020
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26. Cranioectodermal dysplasia (CED) in sisters diagnosed with acute heart failure

Author

Saito, Ayako, primary, Izumi, Isho, additional, Suzuki, Ryutaro, additional, Tsukakoshi, Takashi, additional, Lisheng, Lin, additional, Shiono, Junko, additional, Horigome, Hitoshi, additional, Inagaki, Ryusuke, additional, Hamada, Riku, additional, Hataya, Hiroshi, additional, Ogata, Kentaro, additional, Morisada, Naoya, additional, Nozu, Kandai, additional, Iijima, Kazumoto, additional, and Sumazaki, Ryo, additional

Published
2020
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38. The small molecule STF-62247 induces apoptotic and autophagic cell death in leukemic cells

Author

Kozako, Tomohiro, primary, Sato, Keisuke, additional, Uchida, Yuichiro, additional, Kato, Naho, additional, Aikawa, Akiyoshi, additional, Ogata, Kentaro, additional, Kamimura, Hidetoshi, additional, Uemura, Haruna, additional, Yoshimitsu, Makoto, additional, Ishitsuka, Kenji, additional, Higaki, Yasuki, additional, Tanaka, Hiroaki, additional, Honda, Shin-Ichiro, additional, and Soeda, Shinji, additional

Published
2018
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39. Coagulopathy as a complication of kidney biopsies in paediatric systemic lupus erythematosus patients with antiphospholipid syndrome

Author

Nagata, Hiroko, primary, Sato, Mai, additional, Ogura, Masao, additional, Yoshikawa, Takahisa, additional, Yamamoto, Kazuna, additional, Matsumura, Sohshi, additional, Kano, Yuji, additional, Saida, Ken, additional, Sako, Mayumi, additional, Kamei, Koichi, additional, Yoshioka, Takako, additional, Ogata, Kentaro, additional, Ito, Shuichi, additional, and Ishikura, Kenji, additional

Published
2018
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45. Diversity of renal phenotypes in patients withWDR19mutations: Two case reports

Author

Yoshikawa, Takahisa, primary, Kamei, Koichi, additional, Nagata, Hiroko, additional, Saida, Ken, additional, Sato, Mai, additional, Ogura, Masao, additional, Ito, Shuichi, additional, Miyazaki, Osamu, additional, Urushihara, Maki, additional, Kondo, Shuji, additional, Sugawara, Noriko, additional, Ishizuka, Kiyonobu, additional, Hamasaki, Yuko, additional, Shishido, Seiichiro, additional, Morisada, Naoya, additional, Iijima, Kazumoto, additional, Nagata, Michio, additional, Yoshioka, Takako, additional, Ogata, Kentaro, additional, and Ishikura, Kenji, additional

Published
2017
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47. Analysis of a Questionnaire Survey regarding Current Conditions against Exposure to Anticancer Drugs and Reports of Cancer Chemotherapy at Outpatient Departments in Japan

Author

Shirakawa, Tsuyoshi, primary, Hara, Tomoko, additional, Hata, Kojiro, additional, Suetsugu, Kimitaka, additional, Kakimoto, Hideki, additional, Ogata, Kentaro, additional, Ikari, Yousuke, additional, Sasaki, Hidenori, additional, Takahashi, Makoto, additional, Fukahori, Masaru, additional, Uoi, Miyuki, additional, Esaki, Taito, additional, Hiraike, Mikako, additional, Hayashi, Toshinobu, additional, Tokunaga, Akira, additional, Ureshino, Norio, additional, Kuwamura, Tsuneo, additional, Kusaba, Hitoshi, additional, Mitsugi, Kenji, additional, and Baba, Eishi, additional

Published
2017
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48. A Case of Lipomatous Tumor Arising from the Paratesticular Lesion

Author

Kaneko, Gou, Nishimoto, Koshiro, Ogata, Kentaro, and Uchida, Atsushi

Subjects
Lipomatous tumor, Paratesticular tumor, Lipoma, Liposarcoma, 494.9
Abstract

We encountered a case of lipomatous tumor in the left scrotum, which was clinically and radiologically quite similar to an inguinal hernia. A 75-year-old male patient visited a nearby hospital complaining of a painless left scrotal swelling. Palpation revealed an elastic firm mass 5 cm in diameter in the left scrotum. The tumor marker levels were within the normal range. The patient was referred to our hospital for further evaluation. A preoperative diagnosis of inguinal hernia containing the omentum was made. Although a solid mass was demonstrated in the scrotum, no inguinal hernia was found at the operation. Therefore, a left high inguinal orchiectomy was performed. Microscopically, most of the tumor consisted of mature adipocytes, some of which had different cellular sizes. Scattered lipoblasts and atypical mesenchymal spindle cells were also observed, suggesting potential malignancy.

Published
2009

49. Epididymal leiomyoma: a case report

Author

Ito, Yujiro, Nishimoto, Koshiro, Ogata, Kentaro, Hasebe, Mitsuteru, and Uchida, Atsushi

Subjects
494.9, Epididymal leiomyoma, MRI
Abstract

A 30-year-old male, who underwent orchiopexy of left undescending testis in his childhood, presented with right hemiscrotal swelling without pain. Ultrasonography revealeda paratesticular tumor which showedenhancement on magnetic resonance imaging (MRI). Diffusion-weightedMRI showedd ecreased diffusion in the tumor, andmalignant tumor couldnot be ruledout. High inguinal orchiectomy was carried out and pathological diagnosis was benign leiomyoma of the epididymis.

Published
2009

50. Annular constriction of the rectum secondary to urothelial carcinoma of the bladder

Author

Ito, Yujiro, Nishimoto, Koshiro, Ogata, Kentaro, and Fujioka, Toshio

Subjects
Bladder carcinoma, 494.9
Abstract

74歳男。患者は膀胱腫瘍の診断で, 膀胱全摘除術と代用膀胱造設術が施行され, 病理組織診断で周囲脂肪織に若干の癌浸潤が認められた。術後の化学療法は患者の意向で施行せず, 経過は良好であったが, 術後11ヵ月, 排便困難および肛門からの持続的な粘液の流出が出現し, 大腸イレウスの診断で緊急入院となった。注腸造影では下部直腸から口側に約15cmの狭窄が認められ, MRIでは直腸粘膜, 筋層の全周性の肥厚を認めたが, 明らかな腫瘤は認めなかった。人工肛門造設術と直腸生検を施行したところ, 病理組織学的には直腸筋層内に膀胱癌の浸潤を認めたが, 直腸粘膜内には癌細胞を認めなかった。MVAC療法を開始したが副作用が強く, 中止となり, シスプラチン併用放射線照射が施行された。だが, 大臀筋層内に膀胱癌の転移がみられ, 徐々に全身状態が悪化して, 患者は最終的に死亡となった。, Recurrent urothelial carcinoma of the bladder is often a locally progressive disease. Invasive bladder cancers frequently show lymphatic or hematogenous metastasis. Regional lymph node metastasis is a frequent finding and may be the first sign of recurrence. Rectal involvement and obstruction is rare, but metastasis to the colon, small intestine, and stomach have been reported. Here, we report an unusual case of urothelial carcinoma of the bladder manifesting as an annular rectal obstruction.

Published
2008

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