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4. Test 6

Author

Paddock, Michael, Ní Leidhin, Caoilfhionn, Offiah, Amaka C., Paddock, Michael, Ní Leidhin, Caoilfhionn, and Offiah, Amaka C.

Published
2024
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5. Test 8

Author

Paddock, Michael, Ní Leidhin, Caoilfhionn, Offiah, Amaka C., Paddock, Michael, Ní Leidhin, Caoilfhionn, and Offiah, Amaka C.

Published
2024
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6. Test 5

Author

Paddock, Michael, Ní Leidhin, Caoilfhionn, Offiah, Amaka C., Paddock, Michael, Ní Leidhin, Caoilfhionn, and Offiah, Amaka C.

Published
2024
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7. Test 9

Author

Paddock, Michael, Ní Leidhin, Caoilfhionn, Offiah, Amaka C., Paddock, Michael, Ní Leidhin, Caoilfhionn, and Offiah, Amaka C.

Published
2024
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8. Test 7

Author

Paddock, Michael, Ní Leidhin, Caoilfhionn, Offiah, Amaka C., Paddock, Michael, Ní Leidhin, Caoilfhionn, and Offiah, Amaka C.

Published
2024
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9. Test 4

Author

Paddock, Michael, Ní Leidhin, Caoilfhionn, Offiah, Amaka C., Paddock, Michael, Ní Leidhin, Caoilfhionn, and Offiah, Amaka C.

Published
2024
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10. Test 1

Author

Paddock, Michael, Ní Leidhin, Caoilfhionn, Offiah, Amaka C., Paddock, Michael, Ní Leidhin, Caoilfhionn, and Offiah, Amaka C.

Published
2024
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11. Test 2

Author

Paddock, Michael, Ní Leidhin, Caoilfhionn, Offiah, Amaka C., Paddock, Michael, Ní Leidhin, Caoilfhionn, and Offiah, Amaka C.

Published
2024
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12. Test 3

Author

Paddock, Michael, Ní Leidhin, Caoilfhionn, Offiah, Amaka C., Paddock, Michael, Ní Leidhin, Caoilfhionn, and Offiah, Amaka C.

Published
2024
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13. The impact of HIV infection on skeletal maturity in peripubertal children in Zimbabwe: a cross-sectional study

Author

Farirayi Kowo-Nyakoko, Celia L. Gregson, Leo D. Westbury, Tafadzwa Madanhire, Amaka C. Offiah, Lisa K. Micklesfield, Rashida Abbas Ferrand, Andrea M. Rehman, and Kate A. Ward

Subjects
Adolescence, Africa, Bone age, Children, HIV, Puberty, Pediatrics, RJ1-570
Abstract

Abstract Introduction HIV infection and its treatment compromises skeletal development (growth and maturation). Skeletal maturity is assessed as bone age (BA) on hand and wrist radiographs. BA younger than chronological age (CA) indicates delayed development. We conducted a cross-sectional study to determine differences between BA and CA (i.e., skeletal maturity deviation [SMD]), and risk factors associated with SMD in peripubertal children with and without HIV established on antiretroviral therapy (ART) including use of tenofovir disoproxil fumarate (TDF). Methods Children with HIV taking ART for at least two years and a comparison group of HIV-negative children, aged 8–16 years and frequency-matched by age and sex, were recruited from HIV clinics and local schools in the same catchment area, in Harare, Zimbabwe. BA was assessed from non-dominant hand-wrist radiographs using the Tanner Whitehouse 3 method. Negative SMD values correspond to delayed development, i.e., BA younger than CA. Multivariable linear regression models determined factors associated with SMD overall, and in children with HIV. Results In total, 534 participants (54% males) were included; by design CA was similar in males and females, whether living with or without HIV. Mean (SD) SMD was more negative in CWH than in HIV-negative children in both males [-1.4(1.4) vs. -0.4(1.1) years] and females [-1.1(1.3) vs. -0.0(1.2) years]. HIV infection and weight-for-age Z-score

Published
2024
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14. The incidence of fractures in children under two years of age: a systematic review

Author

Karen Rosendahl, Laura Tanturri de Horatio, Celine Habre, Susan C. Shelmerdine, Janina Patsch, Ola Kvist, Regina K. Lein, Domen Plut, Edvard J. Enoksen, Rien Avenarius, Lene B. Laborie, Thomas A. Augdal, Paolo Simoni, Rick R. van Rijn, Amaka C. Offiah, and on behalf of the European Society of Paediatric Radiology (ESPR) Musculoskeletal and Child Abuse Task Forces

Subjects
Fracture, Infant, Children, Incidence, Paediatric, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Epidemiological research on fractures in children under the age of two is of great importance to help understand differences between accidental and abusive trauma. Objective This systematic review aimed to evaluate studies reporting on the incidence of fractures in children under two years of age, excluding birth injuries. Secondary outcome measures included fracture location, mechanisms of injury and fracture characteristics. Methods A systematic literature review (1946 to February 7th 2024), including prospective and retrospective cohort studies and cross-sectional cohort studies, was performed. Studies including children from other age groups were included if the actual measures for those aged 0–2 years could be extracted. We also included studies restricted to infants. Annual incidence rates of fractures were extracted and reported as the main result. Critical appraisal of was performed using the Appraisal tool for Cross-Sectional Studies. Results Twelve moderate to good quality studies met eligibility criteria, of which seven were based on data from medical records and five were registry studies. Studies investigated different aspects of fractures, making comprehensive synthesis challenging. There was an overall annual fracture incidence rate of 5.3 to 9.5 per 1,000 children from 0–2 years of age; with commonest sites being the radius/ulna (25.2–40.0%), followed by tibia/fibula (17.3–27.6%) and the clavicle (14.6–14.8%) (location based on 3 studies with a total of 407 patients). In infants, the reported incidence ranged between 0.7 to 4.6 per 1,000 (based on 3 studies), with involvement of the clavicle in 22.2% and the distal humerus in 22.2% of cases (based on 1 study). Only a single metaphyseal lesion was reported (proximal humerus of an 11-month-old infant). Fracture mechanisms were detailed in four studies, with fall from chair, bed, table, own height or fall following indoor activities causing 50–60% of fractures. Conclusions There is a paucity of good quality data on fracture incidence in children under the age of two. Larger, prospective and unbiased studies would be helpful in determining normal pattern of injuries, so that differences from abusive trauma may be better understood.

Published
2024
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18. Dyssegmental Dysplasia, HSPG2-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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19. Catel-Manzke Syndrome, TGDS-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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20. Apert Syndrome, FGFR2-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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24. Stüve-Wiedemann Dysplasia, LFR-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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26. Thoracolaryngopelvic Dysplasia (Barnes)

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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27. Menkes Disease, ATP7A-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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29. DK Phocomelia

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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30. Kniest Dysplasia, COL2A1-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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34. Brachydactyly Type C, GDF5-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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38. Cousin Syndrome, TBX15-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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40. Kaufman-McKusick Syndrome, MKKS-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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41. Astley-Kendall Dysplasia

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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46. Blomstrand Dysplasia, PTHR1-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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48. Atelosteogenesis Type 3, FLNB-Related

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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49. Warfarin Embryopathy

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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50. OEIS Complex

Author

Hall, Christine M, primary, Offiah, Amaka C, additional, Forzano, Francesca, additional, Lituania, Mario, additional, Nishimura, Gen, additional, and Cormier-Daire, Valérie, additional

Published
2024
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