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2. Corticosteroid related changes in body mass index in children and adolescents with rheumatic diseases

Author

Shiff Natalie, Brant Rollin, Cabral David A, Guzman Jaime, Dent Peter B, Ellsworth Janet E, Houghton Kristin M, Huber Adam, Jurencak Roman, Lang Bianca A, Larche Maggie, LeBlanc Claire MA, Miettunen Paivi M, Oen Kiem G, Roth Johannes, Saint-Cyr Claire, Scuccimarri Rosie, and Ward Leanne M

Subjects
Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Published
2012
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4. Incident vertebral fractures 12 months following glucocorticoid initiation in children with rheumatic disorders

Author

Lang Bianca A, Rodd Celia, Ramsay Timothy, Cabral David A, Dent Peter B, Ellsworth Janet E, Houghton Kristin M, Huber Adam, Jurencak Roman, Larché Maggie, LeBlanc Claire MA, Lentle Brian, Matzinger MaryAnn, Miettunen Paivi M, Oen Kiem, Roth Johannes, Saint-Cyr Claire, Scuccimarri Rosie, Shenouda Nazih, and Ward Leanne M

Subjects
Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Published
2012
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6. A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry

Author

Nguyen, Kelly, primary, Barsalou, Julie, additional, Basodan, Daniah, additional, Batthish, Michelle, additional, Benseler, Susanne M, additional, Berard, Roberta A, additional, Blanchette, Nicholas, additional, Boire, Gilles, additional, Bolaria, Roxana, additional, Bruns, Alessandra, additional, Cabral, David A, additional, Cameron, Bonnie, additional, Campillo, Sarah, additional, Cellucci, Tania, additional, Chan, Mercedes, additional, Chédeville, Gaëlle, additional, Chetaille, Anne-Laure, additional, Chhabra, Amieleena, additional, Couture, Julie, additional, Dancey, Paul, additional, De Bruycker, Jean-Jacques, additional, Demirkaya, Erkan, additional, Dhalla, Muhammed, additional, Duffy, Ciarán M, additional, Feldman, Brian M, additional, Feldman, Debbie E, additional, Gerschman, Tommy, additional, Haddad, Elie, additional, Heale, Liane, additional, Herrington, Julie, additional, Houghton, Kristin, additional, Huber, Adam M, additional, Human, Andrea, additional, Johnson, Nicole, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Larché, Maggie, additional, Laxer, Ronald M, additional, LeBlanc, Claire M, additional, Lee, Jennifer J Y, additional, Levy, Deborah M, additional, Lim, Lillian, additional, Lim, Lily S H, additional, Luca, Nadia, additional, McGrath, Tara, additional, McMillan, Tamara, additional, Miettunen, Paivi M, additional, Morishita, Kimberly A, additional, Ng, Hon Yan, additional, Oen, Kiem, additional, Park, Jonathan, additional, Petty, Ross E, additional, Proulx-Gauthier, Jean-Philippe, additional, Ramsey, Suzanne, additional, Roth, Johannes, additional, Rosenberg, Alan M, additional, Rozenblyum, Evelyn, additional, Rumsey, Dax G, additional, Schmeling, Heinrike, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Shiff, Natalie J, additional, Silverman, Earl, additional, Soon, Gordon, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tam, Herman, additional, Tse, Shirley M, additional, Tucker, Lori B, additional, Turvey, Stuart, additional, Twilt, Marinka, additional, Duffy, Karen Watanabe, additional, Yeung, Rae S M, additional, and Guzman, Jaime, additional

Published
2023
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7. Cancer risk in childhood-onset systemic lupus

Author

Bernatsky, Sasha, Clarke, Ann E, Labrecque, Jeremy, von Scheven, Emily, Schanberg, Laura E, Silverman, Earl D, Brunner, Hermine I, Haines, Kathleen A, Cron, Randy Q, O’Neil, Kathleen M, Oen, Kiem, Rosenberg, Alan M, Duffy, Ciarán M, Joseph, Lawrence, Lee, Jennifer L, Kale, Mruganka, Turnbull, Elizabeth M, and Ramsey-Goldman, Rosalind

Abstract

Abstract Introduction The aim of this study was to assess cancer incidence in childhood-onset systemic lupus erythematosus (SLE). Methods We ascertained cancers within SLE registries at 10 pediatric centers. Subjects were linked to cancer registries for the observational interval, spanning 1974 to 2009. The ratio of observed to expected cancers represents the standardized incidence ratio (SIR) or relative cancer risk in childhood-onset SLE, versus the general population. Results There were 1020 patients aged

Published
2013

8. Cancer risk in childhood-onset systemic lupus.

Author

Schanberg, Laura, Silverman, Earl, Brunner, Hermine, Haines, Kathleen, Cron, Randy, ONeil, Kathleen, Oen, Kiem, Rosenberg, Alan, Duffy, Ciarán, Joseph, Lawrence, Lee, Jennifer, Kale, Mruganka, Turnbull, Elizabeth, Ramsey-Goldman, Rosalind, Bernatsky, Sasha, Clarke, Ann, Labrecque, Jeremy, and Von Scheven, Emily

Subjects
Adolescent, Age of Onset, Child, Female, Humans, Incidence, Lupus Erythematosus, Systemic, Male, Neoplasms, Registries, Risk Factors
Abstract

INTRODUCTION: The aim of this study was to assess cancer incidence in childhood-onset systemic lupus erythematosus (SLE). METHODS: We ascertained cancers within SLE registries at 10 pediatric centers. Subjects were linked to cancer registries for the observational interval, spanning 1974 to 2009. The ratio of observed to expected cancers represents the standardized incidence ratio (SIR) or relative cancer risk in childhood-onset SLE, versus the general population. RESULTS: There were 1020 patients aged

Published
2013

11. Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort

Author

Shiff, Natalie J., Tupper, Susan, Oen, Kiem, Guzman, Jaime, Lim, Hyun, Lee, Chel Hee, Bryce, Rhonda, Huber, Adam M., Boire, Gilles, Dancey, Paul, Feldman, Brian, Laxer, Ronald, Miettunen, Paivi, Schmeling, Heinrike, Watanabe Duffy, Karen, Levy, Deborah M., Turvey, Stuart, Bolaria, Roxana, Bruns, Alessandra, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Feldman, Debbie Ehrmann, Haddad, Elie, Houghton, Kristin, Johnson, Nicole, Jurencak, Roman, Lang, Bianca, Larche, Maggie, Morishita, Kimberly, Ramsey, Suzanne, Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Spiegel, Lynn, Stringer, Elizabeth, Tse, Shirley M., Yeung, Rae, Duffy, Ciarán M., and Tucker, Lori B.

Published
2018
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12. Validation of the parent global assessment as a health-related quality of life measure in juvenile idiopathic arthritis: results from ReACCh-Out

Author

Oen, Kiem, Toupin-April, Karine, Feldman, Brian M, Berard, Roberta A, Duffy, Ciẚran M, Tucker, Lori B, Tian, Jiahao, Rumsey, Dax G, and Guzman, Jaime

Subjects
Rheumatology, Pharmacology (medical), Clinical Science
Abstract

Objectives To (i) validate the JIA parent global assessment (parent global) as a health-related quality of life (HRQoL) instrument; (ii) evaluate measurement properties of accepted HRQoL measures relative to those of the parent global; and (iii) assess causal pathways determining parent global scores. Methods Data from the Research in Arthritis in Canadian Children emphasizing outcomes (ReACCh-Out) cohort were used. Measurement properties were assessed in 344 patients at enrolment and 6 months later. Causal pathways were tested by structural equation modelling to understand root causes and mediators leading to parent global scores. Results Construct validity was supported by Spearman correlations of 0.53–0.70 for the parent global with the Juvenile Arthritis Quality of Life Questionnaire, Quality of My Life health scale (HRQoML), Pediatric Quality of Life Inventory (PedsQL)-Parent, and Child Health Questionnaire (CHQ)-Physical. Exceptions were PedsQL-Child (0.44) and CHQ-Psychosocial (0.31). Correlations were lower (0.14–0.49) with disease activity measures (physician global assessment of disease activity, active joint count, ESR). Responsiveness of the parent global to improvement according to parent ratings (0.51) was acceptable and within the range (0.32–0.71) of that of other measures. Reliability estimates and measurement errors for all measures were unsatisfactory, likely due to the prolonged time between assessments. Causal pathways for the parent global matched those previously reported for HRQoML. Conclusions Our results offer support for the parent global as a valid measure of HRQoL for JIA. If confirmed, existing studies using the parent global may be re-interpreted, enhancing our knowledge of HRQoL in children with JIA.

Published
2022

15. Contributors

Author

Akikusa, Jonathan, primary, Albani, Salvatore, additional, Allen, Roger, additional, Alsaeid, Khaled, additional, Avčin, Tadej, additional, Babyn, Paul S., additional, Bagga, Arvind, additional, Barron, Karyl S., additional, Becker, Mara L., additional, Benseler, Susanne M., additional, Beukelman, Timothy, additional, Brogan, Paul, additional, Brunner, Hermine I., additional, Burgos-Vargas, Rubèn, additional, Buyon, Jill, additional, Cabral, David A., additional, Choo, Sharon, additional, Cimaz, Rolando, additional, Colbert, Robert Allen, additional, Cole, William G., additional, Davidson, Iris, additional, Benedetti, Fabrizio De, additional, Doria, Andrea S., additional, Dressler, Frank, additional, Duffy, Ciarán M., additional, Eleftheriou, Despina, additional, Feldman, Brian M., additional, Ferguson, Polly J., additional, Fuhlbrigge, Robert, additional, Gattorno, Marco, additional, Grom, Alexei A., additional, Hashkes, Philip J., additional, Houghton, Kristin, additional, Huppertz, Hans-Iko, additional, Ilowite, Norman T., additional, Jaeggi, Edgar, additional, Kastner, Daniel L., additional, Kirton, Adam, additional, Klein-Gitelman, Marisa, additional, Kuchta, Gay, additional, Lane, Jerome Charles, additional, Laxer, Ronald M., additional, LeBlanc, Claire, additional, Leeder, Steven J., additional, Legger, G. Elizabeth, additional, Li, Suzanne C., additional, Lindsley, Carol B., additional, Lovell, Dan, additional, Makitie, Outi, additional, Martini, Alberto, additional, Miller, Frederick W., additional, Morishita, Kimberly, additional, Nigrovic, Peter A., additional, Oen, Kiem G., additional, O'Neil, Kathleen M., additional, Ozen, Seza, additional, Pepmueller, Peri H., additional, Petty, Ross E., additional, Pope, Elena, additional, Prahalad, Sampath, additional, Prakken, Berent, additional, Rapoff, Michael, additional, Rider, Lisa G., additional, Rosé, Carlos Daniel, additional, Rosenbaum, James T., additional, Rosenberg, Alan M., additional, Roth, Johannes, additional, Guillermo, Ricardo Alberto, additional, Schneider, Rayfel, additional, Scott, Christiaan, additional, Sherry, David D., additional, Silverman, Earl, additional, Son, Mary Beth, additional, Sundel, Robert P., additional, Thompson, Susan D., additional, Tiedemann, Karin, additional, Tse, Shirley M.L., additional, Tucker, Lori, additional, Uziel, Yosef, additional, van Montfrans, Joris, additional, Vazques-Mellado, Janitzia, additional, Ward, Leanne, additional, Wedderburn, Lucy R., additional, Wouters, Carine, additional, Wright, James, additional, Wulffraat, Nico M., additional, Zemel, Lawrence, additional, and Zulian, Francesco, additional

Published
2016
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16. The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort

Author

Guzman, Jaime, Oen, Kiem, Huber, Adam M, Watanabe Duffy, Karen, Boire, Gilles, Shiff, Natalie, Berard, Roberta A, Levy, Deborah M, Stringer, Elizabeth, Scuccimarri, Rosie, Morishita, Kimberly, Johnson, Nicole, Cabral, David A, Rosenberg, Alan M, Larché, Maggie, Dancey, Paul, Petty, Ross E, Laxer, Ronald M, Silverman, Earl, Miettunen, Paivi, Chetaille, Anne-Laure, Haddad, Elie, Houghton, Kristin, Spiegel, Lynn, Turvey, Stuart E, Schmeling, Heinrike, Lang, Bianca, Ellsworth, Janet, Ramsey, Suzanne E, Bruns, Alessandra, Roth, Johannes, Campillo, Sarah, Benseler, Susanne, Chédeville, Gaëlle, Schneider, Rayfel, Tse, Shirley M L, Bolaria, Roxana, Gross, Katherine, Feldman, Brian, Feldman, Debbie, Cameron, Bonnie, Jurencak, Roman, Dorval, Jean, LeBlanc, Claire, St. Cyr, Claire, Gibbon, Michele, Yeung, Rae S M, Duffy, Ciarán M, and Tucker, Lori B

Published
2016
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17. Validation of the parent global assessment as a health-related quality of life measure in juvenile idiopathic arthritis: results from ReACCh-Out.

Author

Oen, Kiem, Toupin-April, Karine, Feldman, Brian M, Berard, Roberta A, Duffy, Ciẚran M, Tucker, Lori B, Tian, Jiahao, Rumsey, Dax G, Guzman, Jaime, and investigators, ReACCh-Out

Subjects
*RESEARCH methodology evaluation, *RESEARCH methodology, *JUVENILE idiopathic arthritis, *QUALITY of life
Abstract

Objectives To (i) validate the JIA parent global assessment (parent global) as a health-related quality of life (HRQoL) instrument; (ii) evaluate measurement properties of accepted HRQoL measures relative to those of the parent global; and (iii) assess causal pathways determining parent global scores. Methods Data from the Research in Arthritis in Canadian Children emphasizing outcomes (ReACCh-Out) cohort were used. Measurement properties were assessed in 344 patients at enrolment and 6 months later. Causal pathways were tested by structural equation modelling to understand root causes and mediators leading to parent global scores. Results Construct validity was supported by Spearman correlations of 0.53–0.70 for the parent global with the Juvenile Arthritis Quality of Life Questionnaire, Quality of My Life health scale (HRQoML), Pediatric Quality of Life Inventory (PedsQL)-Parent, and Child Health Questionnaire (CHQ)-Physical. Exceptions were PedsQL-Child (0.44) and CHQ-Psychosocial (0.31). Correlations were lower (0.14–0.49) with disease activity measures (physician global assessment of disease activity, active joint count, ESR). Responsiveness of the parent global to improvement according to parent ratings (0.51) was acceptable and within the range (0.32–0.71) of that of other measures. Reliability estimates and measurement errors for all measures were unsatisfactory, likely due to the prolonged time between assessments. Causal pathways for the parent global matched those previously reported for HRQoML. Conclusions Our results offer support for the parent global as a valid measure of HRQoL for JIA. If confirmed, existing studies using the parent global may be re-interpreted, enhancing our knowledge of HRQoL in children with JIA. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Predicting Which Children with Juvenile Idiopathic Arthritis Will Not Attain Early Remission with Conventional Treatment: Results from the ReACCh-Out Cohort

Author

Guzman, Jaime, Henrey, Andrew, Loughin, Thomas, Berard, Roberta A., Shiff, Natalie J., Jurencak, Roman, Huber, Adam M., Oen, Kiem, Gerhold, Kerstin, Feldman, Brian M., Scuccimarri, Rosie, Houghton, Kristin, Chédeville, Gaëlle, Morishita, Kimberly, Lang, Bianca, Dancey, Paul, Rosenberg, Alan M., Barsalou, Julie, Bruns, Alessandra, Duffy, Karen Watanabe, Benseler, Susanne, Duffy, Ciaran M., Tucker, Lori B., Bolaria, Roxana, Gross, Katherine, Turvey, Stuart E., Cabral, David, Petty, Ross, and Ellsworth, Janet

Subjects
Male, Pediatrics, medicine.medical_specialty, Adolescent, Immunology, Arthritis, Early remission, Logistic regression, Severity of Illness Index, Decile, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, medicine, Humans, Immunology and Allergy, Juvenile, Treatment Failure, 030212 general & internal medicine, Child, Risk stratification, 030203 arthritis & rheumatology, Biological Products, business.industry, Remission Induction, Conventional treatment, Juvenile idiopathic arthritis, Prognosis, medicine.disease, Arthritis, Juvenile, Logistic Models, Treatment Outcome, Antirheumatic Agents, Child, Preschool, Cohort, Cohort studies, Female, Prediction, business, Cohort study
Abstract

Objective.To estimate the probability of early remission with conventional treatment for each child with juvenile idiopathic arthritis (JIA). Children with a low chance of remission may be candidates for initial treatment with biologics or triple disease-modifying antirheumatic drugs (DMARD).Methods.We used data from 1074 subjects in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcome was clinically inactive disease for ≥ 6 months starting within 1 year of JIA diagnosis in patients who did not receive early biologic agents or triple DMARD. Models were developed in 200 random splits of 75% of the cohort and tested on the remaining 25% of subjects, calculating expected and observed frequencies of remission and c-index values.Results.Our best Cox logistic model combining 18 clinical variables a median of 2 days after diagnosis had a c-index of 0.69 (95% CI 0.67–0.71), better than using JIA category alone (0.59, 95% CI 0.56–0.63). Children in the lowest probability decile had a 20% chance of remission and 21% attained remission; children in the highest decile had a 69% chance of remission and 73% attained remission. Compared to 5% of subjects identified by JIA category alone, the model identified 14% of subjects as low chance of remission (probability < 0.25), of whom 77% failed to attain remission.Conclusion.Although the model did not meet our a priori performance threshold (c-index > 0.70), it identified 3 times more subjects with low chance of remission than did JIA category alone, and it may serve as a benchmark for assessing value added by future laboratory/imaging biomarkers.

Published
2019

19. The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort

Author

Guzman, Jaime, Oen, Kiem, Tucker, Lori B, Huber, Adam M, Shiff, Natalie, Boire, Gilles, Scuccimarri, Rosie, Berard, Roberta, Tse, Shirley M L, Morishita, Kimberly, Stringer, Elizabeth, Johnson, Nicole, Levy, Deborah M, Duffy, Karen Watanabe, Cabral, David A, Rosenberg, Alan M, Larché, Maggie, Dancey, Paul, Petty, Ross E, Laxer, Ronald M, Silverman, Earl, Miettunen, Paivi, Chetaille, Anne-Laure, Haddad, Elie, Houghton, Kristin, Spiegel, Lynn, Turvey, Stuart E, Schmeling, Heinrike, Lang, Bianca, Ellsworth, Janet, Ramsey, Suzanne, Bruns, Alessandra, Campillo, Sarah, Benseler, Susanne, Chédeville, Gaëlle, Schneider, Rayfel, Yeung, Rae, Duffy, Ciarán M, Bolaria, Roxana, Gross, Katherine, Feldman, Brian, Feldman, Debbie, Cameron, Bonnie, Jurencak, Roman, Roth, Johannes, Dorval, Jean, LeBlanc, Claire, and St. Cyr, Claire

Published
2015
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20. Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth

Author

Finch, Sarah L., primary, Rosenberg, Alan M., additional, Kusalik, Anthony J., additional, Maleki, Farhad, additional, Rezaei, Elham, additional, Baxter-Jones, Adam, additional, Benseler, Susanne, additional, Boire, Gilles, additional, Cabral, David, additional, Campillo, Sarah, additional, Chédeville, Gaëlle, additional, Chetaille, Anne-Laure, additional, Dancey, Paul, additional, Duffy, Ciaran, additional, Duffy, Karen Watanabe, additional, Guzman, Jaime, additional, Houghton, Kristin, additional, Huber, Adam M., additional, Jurencak, Roman, additional, Lang, Bianca, additional, Laxer, Ron M., additional, Morishita, Kimberly, additional, Oen, Kiem G., additional, Petty, Ross E., additional, Ramsey, Suzanne E., additional, Roth, Johannes, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Stringer, Elizabeth, additional, Tse, Shirley M.L., additional, Tucker, Lori B., additional, Turvey, Stuart E., additional, Szafron, Michael, additional, Whiting, Susan, additional, Yeung, Rae SM, additional, and Vatanparast, Hassan, additional

Published
2021
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21. Additional file 1 of Clinical and psychosocial stress factors are associated with decline in physical activity over time in children with juvenile idiopathic arthritis

Author

Heale, Liane D., Houghton, Kristin M., Rezaei, Elham, Baxter-Jones, Adam D. G., Tupper, Susan M., Muhajarine, Nazeem, Benseler, Susanne M., Boire, Gilles, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Duffy, Karen Watanabe, Ellsworth, Janet, Guzman, Jaime, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Laxer, Ronald M., Morishita, Kimberly, Oen, Kiem G., Petty, Ross E., Ramsey, Suzanne E., Roth, Johannes, Schneider, Rayfel, Scuccimarri, Rosie, Spiegel, Lynn, Stringer, Elizabeth, Tse, Shirley M. L., Tucker, Lori B., Turvey, Stuart E., Yeung, Rae S. M., and Rosenberg, Alan M.

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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22. A154: Glucocorticoid Therapy and the Risk of Incident Vertebral Fracture in Children with Rheumatic Disorders

Author

LeBlanc, Claire M. A., Ma, Jinhui, Scuccimarri, Rosie, Cabral, David A., Dent, Peter B., Ellsworth, Janet E., Houghton, Kristin, Huber, Adam M., Jurencak, Roman, Lang, Bianca A., Larche, Maggie, Lentle, Brian, Matzinger, Mary Ann, Miettunen, Paivi M., Oen, Kiem, Roth, Johannes, Saint-Cyr, Claire, Shenouda, Nazih, Taljaard, Monica, and Ward, Leanne M.

Published
2014
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23. A Comparison of International League of Associations for Rheumatology and Pediatric Rheumatology International Trials Organization Classification Systems for Juvenile Idiopathic Arthritis Among Children in a Canadian Arthritis Cohort.

Author

Lee, Jennifer J. Y., Eng, Simon W. M., Guzman, Jaime, Duffy, Ciáran M., Tucker, Lori B., Oen, Kiem, Yeung, Rae S. M., and Feldman, Brian M.

Subjects
RHEUMATOLOGY, JUVENILE idiopathic arthritis, COMPARATIVE studies, DESCRIPTIVE statistics, INTERNATIONAL agencies, LONGITUDINAL method
Abstract

Objective: The aim of the Paediatric Rheumatology International Trials Organisation (PRINTO) juvenile idiopathic arthritis (JIA) classification criteria, which is still in development, is to identify homogeneous groups of JIA patients. This study was undertaken to compare International League of Associations for Rheumatology (ILAR) JIA classification criteria and PRINTO JIA classification criteria using data from the ReACCh‐Out (Research in Arthritis in Canadian Children, Emphasizing Outcomes) cohort. Methods: We used clinicobiologic data recorded within 7 months of diagnosis to assign a diagnosis of JIA and identify subcategories of JIA among 1,228 patients according to the 2 JIA classification systems. We compared the proportions of patients classified and the alignment of classification categories with clinicobiologic subtypes and adult arthritis types. Results: The PRINTO criteria classified 244 patients (19.9%) as having early‐onset antinuclear antibody–positive JIA, 157 (12.8%) as having enthesitis/spondylitis–related JIA, 38 (3.1%) as having systemic JIA, and 10 (0.8%) as having rheumatoid factor–positive JIA. A total of 12% of patients were unclassifiable using the ILAR criteria, while 63.3% were unclassifiable using the PRINTO criteria (777 with other JIA and 2 with unclassified JIA). In sensitivity analyses, >50% of patients remained unclassifiable using the PRINTO criteria. Compared to the PRINTO criteria, ILAR JIA categories aligned better with clinicobiologic subtypes in 131 patients (χ2 = 44, P = 0.005, versus χ2 = 15, P = 0.07 for PRINTO), and ILAR categories aligned better with adult types of arthritis in 389 evaluable patients. Conclusion: Currently identified PRINTO disorders can only be used to classify a minority of JIA patients, leaving a large proportion of JIA patients with other disorders requiring further characterization. Current PRINTO JIA classification criteria do not align better with clinicobiologic subtypes or adult forms of arthritis compared with the older ILAR classification system. [ABSTRACT FROM AUTHOR]

Published
2022
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25. CONTRIBUTORS

Author

Albani, Salvatore, primary, Alsaeid, Khaled, additional, Athreya, Balu H., additional, Avčin, Tadej, additional, Babyn, Paul, additional, Bagga, Arvind, additional, Barron, Karyl S., additional, Benseler, Susanne, additional, Brogan, Paul, additional, Brunner, Hermine I., additional, Burgos-Vargas, Rubén, additional, Buyon, Jill P., additional, Cabral, David A., additional, Cassidy, James T., additional, Cimaz, Rolando, additional, Colbert, Robert A., additional, Davidson, Iris L., additional, De Benedetti, Fabrizio, additional, Dillon, Michael J., additional, Doria, Andrea Schwarz, additional, Dressler, Frank, additional, Duffy, Ciarán M., additional, Eddy, Allison A., additional, Falcini, Fernanda, additional, Feldman, Brian M., additional, Ferguson, Polly J., additional, Fuhlbrigge, Robert C., additional, Gattorno, Marco, additional, Giannini, Edward H., additional, Glass, David N., additional, Grom, Alexei A., additional, Houghton, Kristin, additional, Huppertz, Hans-Iko, additional, Ilowite, Norman T., additional, Kastner, Daniel L., additional, Kuchta, Gay, additional, Kuis, Wietse, additional, Laxer, Ronald M., additional, LeBlanc, Claire, additional, Lindsley, Carol B., additional, Martini, Alberto, additional, Nigrovic, Peter A., additional, O'Neil, Kathleen M., additional, Oen, Kiem G., additional, Özen, Seza, additional, Pepmueller, Peri Hickman, additional, Prakken, Berent J., additional, Rapoff, Michael A., additional, Rider, Lisa G., additional, Rosé, Carlos D., additional, Rosenbaum, James T., additional, Rosenberg, Alan M., additional, Schneider, Rayfel, additional, Sherry, David D., additional, Silverman, Earl D., additional, Sundel, Robert P., additional, Thompson, Susan D., additional, Tucker, Lori B., additional, van Montfrans, Joris, additional, Vázquez-Mellado, Janitzia, additional, Wenkert, Deborah, additional, Wouters, Carine H., additional, Wulffraat, Nico, additional, and Zulian, Francesco, additional

Published
2011
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27. Teens Taking Charge: A Randomized Controlled Trial of a Web-Based Self-Management Program With Telephone Support for Adolescents With Juvenile Idiopathic Arthritis

Author

Stinson, Jennifer N, primary, Lalloo, Chitra, additional, Hundert, Amos S, additional, Campillo, Sarah, additional, Cellucci, Tania, additional, Dancey, Paul, additional, Duffy, Ciaran, additional, Ellsworth, Janet, additional, Feldman, Brian M, additional, Huber, Adam M, additional, Johnson, Nicole, additional, Jong, Geert't, additional, Oen, Kiem, additional, Rosenberg, Alan M, additional, Shiff, Natalie J, additional, Spiegel, Lynn, additional, Tse, Shirley M L, additional, Tucker, Lori, additional, and Victor, Joseph Charles, additional

Published
2020
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28. Clinical and associated inflammatory biomarker features predictive of short-term outcomes in non-systemic juvenile idiopathic arthritis

Author

Rezaei, Elham, primary, Hogan, Daniel, additional, Trost, Brett, additional, Kusalik, Anthony J, additional, Boire, Gilles, additional, Cabral, David A, additional, Campillo, Sarah, additional, Chédeville, Gaëlle, additional, Chetaille, Anne-Laure, additional, Dancey, Paul, additional, Duffy, Ciaran, additional, Watanabe Duffy, Karen, additional, Gordon, John, additional, Guzman, Jaime, additional, Houghton, Kristin, additional, Huber, Adam M, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Morishita, Kimberly, additional, Oen, Kiem G, additional, Petty, Ross E, additional, Ramsey, Suzanne E, additional, Scuccimarri, Rosie, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Taylor-Gjevre, Regina M, additional, Tse, Shirley M L, additional, Tucker, Lori B, additional, Turvey, Stuart E, additional, Tupper, Susan, additional, Yeung, Rae S M, additional, Benseler, Susanne, additional, Ellsworth, Janet, additional, Guillet, Chantal, additional, Karananayake, Chandima, additional, Muhajarine, Nazeem, additional, Roth, Johannes, additional, Schneider, Rayfel, additional, and Rosenberg, Alan M, additional

Published
2020
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29. Predictors of Early Inactive Disease in a Juvenile Idiopathic Arthritis Cohort: Results of a Canadian Multicenter, Prospective Inception Cohort Study

Author

OEN, KIEM, TUCKER, LORI, HUBER, ADAM M., MIETTUNEN, PAIVI, SCUCCIMARRI, ROSIE, CAMPILLO, SARAH, CABRAL, DAVID A., FELDMAN, BRIAN M., TSE, SHIRLEY, CHéDEVILLE, GAëLLE, SPIEGEL, LYNN, SCHNEIDER, RAYFEL, LANG, BIANCA, ELLSWORTH, JANET, RAMSEY, SUZANNE, DANCEY, PAUL, SILVERMAN, EARL, CHETAILLE, ANNE-LAURE, CAMERON, BONNIE, JOHNSON, NICOLE, DORVAL, JEAN, PETTY, ROSS E., DUFFY, KAREN WATANABE, BOIRE, GILLES, HADDAD, ELIE, HOUGHTON, KRISTIN, SAINT-CYR, CLAIRE, TURVEY, STUART E., BENSELER, SUSANNE, CHEANG, MARY, YEUNG, RAE S. M., and DUFFY, CIARáN M.

Published
2009
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30. Causal pathways to health-related quality of life in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort.

Author

Oen, Kiem, Tian, Jiahao, Loughin, Thomas M, Shiff, Natalie J, Tucker, Lori B, Huber, Adam M, Berard, Roberta A, Levy, Deborah M, Rumsey, Dax G, Tse, Shirley M, Chan, Mercedes, Feldman, Brian M, Duffy, Ciaran M, Guzman, Jaime, and Investigators, for the ReACCh-Out

Subjects
*STRUCTURAL equation modeling, *JUVENILE idiopathic arthritis, *QUALITY of life, *CAUSAL models
Abstract

Objective Structural equation modelling was applied to data from the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort to help elucidate causal pathways to decreased health-related quality of life (HRQoL) in children with JIA. Methods Based on published literature and clinical plausibility, a priori models were constructed with explicit root causes (disease activity, treatment intensity) and mediators (pain, disease symptoms, functional impairments) leading to HRQoL [measured by the Quality of my Life (QoML) scale and the Juvenile Arthritis Quality of Life Questionnaire (JAQQ)] at five disease stages: (i) diagnosis, (ii) 3–9 months after diagnosis, (iii) flare, (iv) remission on medications, (v) remission off medications. Following structural equation modelling, a posteriori models were selected based on data fit and clinical plausibility. Results We included 561, 887, 137, 186 and 182 patients at each stage, respectively. In a posteriori models for active disease stages, paths from disease activity led through pain, functional impairments, and disease symptoms, directly or through restrictions in participation, to decreased QoML scores. Treatment intensity had detrimental effects through psychosocial domains; while treatment side effects had a lesser role. Pathways were similar for QoML and JAQQ, but JAQQ models provided greater specificity. Models for remission stages were not supported by the data. Conclusion Our findings support disease activity and treatment intensity as being root causes of decreased HRQoL in children with JIA, with pain, functional impairments, and participation restrictions being mediators for disease activity; they support psychosocial effects and side effects as being mediators for treatment intensity. [ABSTRACT FROM AUTHOR]

Published
2021
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32. Health-Related Quality of Life in an Inception Cohort of Children With Juvenile Idiopathic Arthritis: A Longitudinal Analysis

Author

Oen, Kiem, Guzman, Jaime, Dufault, Brenden, Tucker, Lori B, Shiff, Natalie J, Duffy, Karen Watanabe, Lee, Jennifer J Y, Feldman, Brian M, Berard, Roberta A, Dancey, Paul, Huber, Adam M, Scuccimarri, Rosie, Cabral, David A, Morishita, Kimberly A, Ramsey, Suzanne E, Rosenberg, Alan M, Boire, Gilles, Benseler, Susanne M, Lang, Bianca, Houghton, Kristin, Miettunen, Paivi M, Chédeville, Gaëlle, Levy, Deborah M, Bruns, Alessandra, Schmeling, Heinrike, Haddad, Elie, Yeung, Rae S M, Duffy, Ciarán M, and The Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) investigators

Subjects
Male, Pediatrics, Time Factors, Arthritis, Child Behavior, Disability Evaluation, 0302 clinical medicine, Child Development, Quality of life, Surveys and Questionnaires, Medicine, longitudinal studies, Longitudinal Studies, 030212 general & internal medicine, Child, Pain Measurement, Oligoarthritis, adolescent development, Age Factors, Prognosis, humanities, female, arthritis, Predictive value of tests, Child, Preschool, Cohort, Female, Polyarthritis, medicine.medical_specialty, age factors, Canada, Adolescent, disability evaluation, adolescent behavior, pain measurement, preschool, 03 medical and health sciences, Rheumatology, Predictive Value of Tests, Humans, Survival analysis, 030203 arthritis & rheumatology, business.industry, Adolescent Development, medicine.disease, Child development, Arthritis, Juvenile, juvenile, quality of life, Adolescent Behavior, Quality of Life, business
Abstract

Objective To describe changes in health-related quality of life (HRQoL) over time in children with juvenile idiopathic arthritis (JIA), relative to other outcomes, and to identify predictors of unfavorable HRQoL trajectories. Methods Children with JIA in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort were included. The Juvenile Arthritis Quality of Life Questionnaire (JAQQ, a standardized instrument), health-related Quality of My Life (HRQoML, an instrument based on personal valuations), and JIA core variables were completed serially. Analyses included median values, Kaplan-Meier survival curves, and latent trajectory analysis. Results A total of 1,249 patients enrolled at a median of 0.5 months after diagnosis were followed for a median of 34.2 months. The degree of initial HRQoL impairment and probabilities of reaching the best possible HRQoL scores varied across JIA categories (best for oligoarthritis, worst for rheumatoid factor–positive polyarthritis). Median times to attain best possible HRQoL scores (JAQQ 59.3 months, HRQoML 34.5 months), lagged behind those for disease activity, pain, and disability measures. Most patients followed trajectories with minimal or mild impairment; however, 7.6% and 13.8% of patients, respectively, followed JAQQ and HRQoML trajectories with persistent major impairment in HRQoL. JIA category, aboriginal ethnicity, and baseline disease activity measures distinguished between membership in trajectories with major and minimal impairments. Conclusion Improvement in HRQoL is slower than for disease activity, pain, and disability. Improvement of a measure based on respondents’ preferences (HRQoML) is more rapid than that of a standardized measure (JAQQ). Higher disease activity at diagnosis heralds an unfavorable HRQoL trajectory.

Published
2018

33. Teens Taking Charge: A Randomized Controlled Trial of a Web-Based Self-Management Program With Telephone Support for Adolescents With Juvenile Idiopathic Arthritis (Preprint)

Author

Stinson, Jennifer N, primary, Lalloo, Chitra, additional, Hundert, Amos S, additional, Campillo, Sarah, additional, Cellucci, Tania, additional, Dancey, Paul, additional, Duffy, Ciaran, additional, Ellsworth, Janet, additional, Feldman, Brian M, additional, Huber, Adam M, additional, Johnson, Nicole, additional, Jong, Geert't, additional, Oen, Kiem, additional, Rosenberg, Alan M, additional, Shiff, Natalie J, additional, Spiegel, Lynn, additional, Tse, Shirley M L, additional, Tucker, Lori, additional, and Victor, Joseph Charles, additional

Published
2019
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35. Soluble Low-density Lipoprotein Receptor-related Protein 1 in Juvenile Idiopathic Arthritis.

Author

Rezaei, Elham, Newkirk, Marianna M., Zhenhong Li, Gordon, John R., Oen, Kiem G., Benseler, Susanne M., Boire, Gilles, Cabral, David A., Campillo, Sarah, Chédeville, Gaëlle, Chetaille, Anne-Laure, Dancey, Paul, Duffy, Ciaran, Watanabe Duffy, Karen, Houghton, Kristin, Huber, Adam M., Jurencak, Roman, Lang, Bianca, Morishita, Kimberly A., and Petty, Ross E.

Published
2021
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36. Seasonal onset of systemic-onset juvenile rheumatoid arthritis

Author

Feldman, Brian M., Birdi, Nina, Boone, James E., Dent, Peter B., Duffy, Ciaran M., Ellsworth, Janet E., Lang, Bianca A., Laxer, Ronald M., Lewkonia, Raymond M., Malleson, Peter N., Oen, Kiem G., Paquin, Julie D., Rosenberg, Alan M., Schneider, Rayfel, and Silverman, Earl D.

Published
1996

37. Real-World Effectiveness of Common Treatment Strategies for Juvenile Idiopathic Arthritis: Results From a Canadian Cohort.

Author

Chhabra, Amieleena, Oen, Kiem, Huber, Adam M., Shiff, Natalie J., Boire, Gilles, Benseler, Susanne M., Berard, Roberta A., Scuccimarri, Rosie, Feldman, Brian M., Lim, Lily Siok Hoon, Barsalou, Julie, Bruns, Alessandra, Cabral, David A., Chédeville, Gaëlle, Ellsworth, Janet, Houghton, Kristin, Lang, Bianca, Morishita, Kimberly, Rumsey, Dax G., and Rosenberg, Alan M.

Abstract

Objective: Undervaluing the effectiveness of conventional treatments may lead to overtreatment with biologic medications in children with juvenile idiopathic arthritis (JIA). Using data from a nationwide inception cohort and strict methods to control bias, the aim of our study was to estimate the real-world effectiveness of simple JIA treatment strategies recommended in current guidelines.Methods: Children with JIA who were recruited at 16 Canadian centers from 2005 to 2010 were followed for up to 5 years. For each child, all observed treatment changes over time were assessed by independent physicians using prospectively collected data and published response criteria. Success was defined as attainment of inactive disease or maintenance of this state when stepping down treatment; minimally active disease was deemed acceptable for children with polyarticular JIA. Success rates were calculated for treatments tried ≥25 times, and logistic regression analysis identified features associated with success.Results: A total of 4,429 treatment episodes were observed in 1,352 children. Nonsteroidal antiinflammatory drug (NSAID) monotherapy was attempted 697 times, mostly as initial treatment when <5 joints were involved, with a 54.4% success rate (95% confidence interval [95% CI] 50.3-58.6). NSAIDs plus joint injections had a 64.7% success rate (95% CI 59.8-69.7). Adding methotrexate to NSAIDs and/or joint injections (attempted 566 times) had a 60.5% success rate (95% CI 55.7-65.3). In adjusted analyses, each additional active joint reduced chances of success for treatment with NSAIDs (odds ratio [OR] 0.90 [95% CI 0.85-0.94]) and for methotrexate combinations (OR 0.96 [95% CI 0.94-0.99]). Each additional year after disease onset reduced chances of success for treatment with methotrexate combinations (OR 0.83 [95% CI 0.72-0.95]).Conclusion: These real-world effectiveness estimates show that conventional nonbiologic treatment strategies that are recommended in current guidelines are effective in achieving treatment targets in many children with JIA. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort

Author

Shiff, Natalie J., primary, Tupper, Susan, additional, Oen, Kiem, additional, Guzman, Jaime, additional, Lim, Hyun, additional, Lee, Chel Hee, additional, Bryce, Rhonda, additional, Huber, Adam M., additional, Boire, Gilles, additional, Dancey, Paul, additional, Feldman, Brian, additional, Laxer, Ronald, additional, Miettunen, Paivi, additional, Schmeling, Heinrike, additional, Watanabe Duffy, Karen, additional, Levy, Deborah M., additional, Turvey, Stuart, additional, Bolaria, Roxana, additional, Bruns, Alessandra, additional, Cabral, David A., additional, Campillo, Sarah, additional, Chédeville, Gaëlle, additional, Feldman, Debbie Ehrmann, additional, Haddad, Elie, additional, Houghton, Kristin, additional, Johnson, Nicole, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Larche, Maggie, additional, Morishita, Kimberly, additional, Ramsey, Suzanne, additional, Roth, Johannes, additional, Schneider, Rayfel, additional, Scuccimarri, Rosie, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Tse, Shirley M., additional, Yeung, Rae, additional, Duffy, Ciarán M., additional, and Tucker, Lori B., additional

Published
2017
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39. Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort

Author

Guzman, Jaime, primary, Kerr, Tristan, additional, Ward, Leanne M., additional, Ma, Jinhui, additional, Oen, Kiem, additional, Rosenberg, Alan M., additional, Feldman, Brian M., additional, Boire, Gilles, additional, Houghton, Kristin, additional, Dancey, Paul, additional, Scuccimarri, Rosie, additional, Bruns, Alessandra, additional, Huber, Adam M., additional, Watanabe Duffy, Karen, additional, Shiff, Natalie J., additional, Berard, Roberta A., additional, Levy, Deborah M., additional, Stringer, Elizabeth, additional, Morishita, Kimberly, additional, Johnson, Nicole, additional, Cabral, David A., additional, Larché, Maggie, additional, Petty, Ross E., additional, Laxer, Ronald M., additional, Silverman, Earl, additional, Miettunen, Paivi, additional, Chetaille, Anne-Laure, additional, Haddad, Elie, additional, Spiegel, Lynn, additional, Turvey, Stuart E., additional, Schmeling, Heinrike, additional, Lang, Bianca, additional, Ellsworth, Janet, additional, Ramsey, Suzanne E., additional, Roth, Johannes, additional, Campillo, Sarah, additional, Benseler, Susanne, additional, Chédeville, Gaëlle, additional, Schneider, Rayfel, additional, Tse, Shirley M. L., additional, Bolaria, Roxana, additional, Gross, Katherine, additional, Feldman, Debbie, additional, Cameron, Bonnie, additional, Jurencak, Roman, additional, Dorval, Jean, additional, LeBlanc, Claire, additional, St. Cyr, Claire, additional, Gibbon, Michele, additional, Yeung, Rae S. M., additional, Duffy, Ciarán M., additional, and Tucker, Lori B., additional

Published
2017
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40. Malignancy in Pediatric-onset Systemic Lupus Erythematosus

Author

Bernatsky, Sasha, primary, Clarke, Ann E., additional, Zahedi Niaki, Omid, additional, Labrecque, Jeremy, additional, Schanberg, Laura E., additional, Silverman, Earl D., additional, Hayward, Kristen, additional, Imundo, Lisa, additional, Brunner, Hermine I., additional, Haines, Kathleen A., additional, Cron, Randy Q., additional, Oen, Kiem, additional, Wagner-Weiner, Linda, additional, Rosenberg, Alan M., additional, O’Neil, Kathleen M., additional, Duffy, Ciarán M., additional, von Scheven, Emily, additional, Joseph, Lawrence, additional, Lee, Jennifer L., additional, and Ramsey-Goldman, Rosalind, additional

Published
2017
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41. Worse Quality of Life, Function, and Pain in Children With Enthesitis, Irrespective of Their Juvenile Arthritis Category

Author

Rumsey, Dax G., Guzman, Jaime, Rosenberg, Alan M., Huber, Adam M., Scuccimarri, Rosie, Shiff, Natalie J., Bruns, Alessandra, Feldman, Brian M., Eurich, Dean T., Benseler, Susanne, Berard, Roberta, Boire, Gilles, Bolaria, Roxana, Cabral, David, Cameron, Bonnie, Campillo, Sarah, Chan, Mercedes, Chédeville, Gaëlle, Chetaille, Anne‐Laure, Dancey, Paul, Dorval, Jean, Duffy, Ciarán, Ellsworth, Janet, Feldman, Debbie, Gross, Katherine, Haddad, Ellie, Houghton, Kristin, Johnson, Nicole, Jurencak, Roman, Lang, Bianca, Larché, Maggie, Laxer, Ronald, LeBlanc, Claire, Levy, Deborah, Luca, Nadia, Miettunen, Paivi, Morishita, Kimberly, Oen, Kiem, Petty, Ross, Ramsey, Suzanne, Roth, Johannes, Saint‐Cyr, Claire, Schmeling, Heinrike, Schneider, Rayfel, Silverman, Earl, Spiegel, Lynn, Stringer, Elizabeth, Tse, Shirley, Tucker, Lori, Turvey, Stuart, Watanabe Duffy, Karen, and Yeung, Rae

Abstract

To estimate the impact of enthesitis on patient‐reported outcomes in children with juvenile idiopathic arthritis (JIA), irrespective of JIAcategory. Children enrolled in the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort were studied. Entheseal tenderness by physician examination in 33 defined locations, Juvenile Arthritis Quality of Life Questionnaire (JAQQ), Quality of My Life (QoML) Questionnaire, Childhood Health Assessment Questionnaire (C‐HAQ), and a pain visual analog scale were completed at enrollment, every 6 months for 2 years, and then yearly up to 5 years. Analyses consisted of descriptive statistics, linear mixed models for longitudinal data, and analysis of covariance. Among 1,371 patients followed for a median of 35.3 months (interquartile range 22.1, 49.2), 214 (16%) had enthesitis, of whom 137 (64%) were classified as having enthesitis‐related arthritis. After adjusting for JIAcategory and covariates, children with enthesitis reported higher JAQQ(mean raw score 2.71 versus 2.16, adjusted difference 0.41 points; 95% confidence interval [95% CI] 0.22, 0.59), higher C‐HAQ(0.47 versus 0.31, adjusted difference 0.14 points; 95% CI0.07, 0.22), higher pain (3.01 versus 1.68, adjusted difference 0.94 points; 95% CI0.64, 1.25), and lower QoML(7.02 versus 8.23, adjusted difference –0.80 points; 95% CI–1.09, –0.51) scores than children without enthesitis. These differences persisted up to 5 years. Children with enthesitis, regardless of JIAcategory, report worse patient‐reported outcomes than those without enthesitis. Thus, enthesitis should be assessed in all children with JIA.

Published
2020
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42. Prospective Determination of the Incidence and Risk Factors of New-Onset Uveitis in Juvenile Idiopathic Arthritis: The Research in Arthritis in Canadian Children Emphasizing Outcomes Cohort.

Author

Lee, Jennifer J. Y., Duffy, Ciarán M., Guzman, Jaime, Oen, Kiem, Barrowman, Nick, Rosenberg, Alan M., Shiff, Natalie J., Boire, Gilles, Stringer, Elizabeth, Spiegel, Lynn, Morishita, Kimberly A., Lang, Bianca, Reddy, Deepti, Huber, Adam M., Cabral, David A., Feldman, Brian M., Yeung, Rae S. M., Tucker, Lori B., Watanabe Duffy, Karen, and ReACCh-Out Investigators

Subjects
AUTOANTIBODIES, RESEARCH, AGE distribution, RESEARCH methodology, JUVENILE idiopathic arthritis, DISEASE incidence, EVALUATION research, MEDICAL cooperation, UVEITIS, COMPARATIVE studies, KAPLAN-Meier estimator, RESEARCH funding, LONGITUDINAL method, PROPORTIONAL hazards models, DISEASE complications
Abstract

Objective: Identification of the incidence of juvenile idiopathic arthritis (JIA)-associated uveitis and its risk factors is essential to optimize early detection. Data from the Research in Arthritis in Canadian Children Emphasizing Outcomes inception cohort were used to estimate the annual incidence of new-onset uveitis following JIA diagnosis and to identify associated risk factors.Methods: Data were reported every 6 months for 2 years, then yearly to 5 years. Incidence was determined by Kaplan-Meier estimators with time of JIA diagnosis as the reference point. Univariate log-rank analysis identified risk factors and Cox regression determined independent predictors.Results: In total, 1,183 patients who enrolled within 6 months of JIA diagnosis met inclusion criteria, median age at diagnosis of 9.0 years (interquartile range [IQR] 3.8-12.9), median follow-up of 35.2 months (IQR 22.7-48.3). Of these patients, 87 developed uveitis after enrollment. The incidence of new-onset uveitis was 2.8% per year (95% confidence interval [95% CI] 2.0-3.5) in the first 5 years. The annual incidence decreased during follow-up but remained at 2.1% (95% CI 0-4.5) in the fifth year, although confidence intervals overlapped. Uveitis was associated with young age (<7 years) at JIA diagnosis (hazard ratio [HR] 8.29, P < 0.001), positive antinuclear antibody (ANA) test (HR 3.20, P < 0.001), oligoarthritis (HR 2.45, P = 0.002), polyarthritis rheumatoid factor negative (HR 1.65, P = 0.002), and female sex (HR 1.80, P = 0.02). In multivariable analysis, only young age at JIA diagnosis and ANA positivity were independent predictors of uveitis.Conclusion: Vigilant uveitis screening should continue for at least 5 years after JIA diagnosis, and priority for screening should be placed on young age (<7 years) at JIA diagnosis and a positive ANA test. [ABSTRACT FROM AUTHOR]

Published
2019
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43. Malignancy incidence in 5294 patients with juvenile arthritis

Author

Zahedi Niaki, Omid, primary, Clarke, Ann E, additional, Ramsey-Goldman, Rosalind, additional, Yeung, Rae, additional, Hayward, Kristen, additional, Oen, Kiem, additional, Duffy, Ciarán M, additional, Rosenberg, Alan, additional, O'Neil, Kathleen M, additional, von Scheven, Emily, additional, Schanberg, Laura, additional, Labrecque, Jeremy, additional, Tse, Shirley M L, additional, Hasija, Rachana, additional, Lee, Jennifer L F, additional, and Bernatsky, Sasha, additional

Published
2016
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44. Incident vertebral fractures 12 months following glucocorticoid initiation in children with rheumatic disorders

Author

Lang, Bianca A, Rodd, Celia, Ramsay, Timothy, Cabral, David A, Dent, Peter B, Ellsworth, Janet E, Houghton, Kristin M, Huber, Adam, Jurencak, Roman, Larche, Maggie, LeBlanc, Claire MA, Lentle, Brian, Matzinger, MaryAnn, Miettunen, Paivi M, Oen, Kiem, Roth, Johannes, Saint-Cyr, Claire, Scuccimarri, Rosie, Shenouda, Nazih, Ward, Leanne M, Canadian STOPP Consortium, and University of Manitoba

Published
2012

47. The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort

Author

Guzman, Jaime, primary, Oen, Kiem, additional, Huber, Adam M, additional, Watanabe Duffy, Karen, additional, Boire, Gilles, additional, Shiff, Natalie, additional, Berard, Roberta A, additional, Levy, Deborah M, additional, Stringer, Elizabeth, additional, Scuccimarri, Rosie, additional, Morishita, Kimberly, additional, Johnson, Nicole, additional, Cabral, David A, additional, Rosenberg, Alan M, additional, Larché, Maggie, additional, Dancey, Paul, additional, Petty, Ross E, additional, Laxer, Ronald M, additional, Silverman, Earl, additional, Miettunen, Paivi, additional, Chetaille, Anne-Laure, additional, Haddad, Elie, additional, Houghton, Kristin, additional, Spiegel, Lynn, additional, Turvey, Stuart E, additional, Schmeling, Heinrike, additional, Lang, Bianca, additional, Ellsworth, Janet, additional, Ramsey, Suzanne E, additional, Bruns, Alessandra, additional, Roth, Johannes, additional, Campillo, Sarah, additional, Benseler, Susanne, additional, Chédeville, Gaëlle, additional, Schneider, Rayfel, additional, Tse, Shirley M L, additional, Bolaria, Roxana, additional, Gross, Katherine, additional, Feldman, Brian, additional, Feldman, Debbie, additional, Cameron, Bonnie, additional, Jurencak, Roman, additional, Dorval, Jean, additional, LeBlanc, Claire, additional, St. Cyr, Claire, additional, Gibbon, Michele, additional, Yeung, Rae S M, additional, Duffy, Ciarán M, additional, and Tucker, Lori B, additional

Published
2015
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49. What Matters Most for Patients, Parents, and Clinicians in the Course of Juvenile Idiopathic Arthritis? A Qualitative Study

Author

Guzman, Jaime, primary, Gómez-Ramírez, Oralia, additional, Jurencak, Roman, additional, Shiff, Natalie J., additional, Berard, Roberta A., additional, Duffy, Ciaran M., additional, Oen, Kiem, additional, Petty, Ross E., additional, Benseler, Susanne M., additional, Brant, Rollin, additional, and Tucker, Lori B., additional

Published
2014
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