Search

Fitri Octaviana,1,2 Ahmad Yanuar Safri,1,2 Winnugroho Wiratman,1– 3 Luh Ari Indrawati,1,2 Nurul Fadli,1,3 Manfaluthy Hakim1,2 1Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 2Department of Neurology, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; 3Universitas Indonesia Hospital, Depok, IndonesiaCorrespondence: Fitri Octaviana, Email fitri.octaviana@ui.ac.idPurpose: Myasthenia gravis (MG) can cause respiratory muscle weakness and the need of ventilator support. Spirometry as the gold standard for pulmonary function examination has limited availability, especially in our hospital which is only available in outpatient clinic during work hours (not in emergency room or patient room). Furthermore, all primary healthcare in Indonesia do not have spirometry equipment, thus other alternatives are required. This study aimed to analyze the relationship between a single breath counting test (SBCT), peak flow meter (PFM), and spirometry to assess pulmonary function in MG patients in a national referral hospital in Indonesia.Patients and Methods: A single-center, cross-sectional study was conducted and SBCT, PFM, and spirometry examination were performed in MG patients and healthy controls.Results: Seventy patients, aged 47.7 ± 13.4 years old, participated in this study. SBCT, forced vital capacity first second (FVC1), and forced expiratory volume first second (FEV1) value between MG patients and healthy controls showed a significant difference, in which healthy controls have higher SBCT, FVC1, and FEV1 values (p = 0.000, p = 0.000 and p = 0.001 respectively). There was a significant difference between PFM with SBCT and FVC1 value in MG patients. Strong correlation was found between SBCT and FVC1 in MG patients.Conclusion: MG patients had worse pulmonary function compared to healthy controls. SBCT and PFM examination have a significant correlation with FVC1 in MG patients. Therefore, SBCT and PFM can be used as a bedside too

Ifran Saleh,1 Didik Librianto,2 Ismail Hadisoebroto Dilogo,3 Sugeng Supriadi,4 Wresti Indriatmi,5 Fitri Octaviana,6 Marcel Prasetyo,7 Zairin Noor8 1Orthopaedic Spine Surgeon, Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia; 2Orthopaedic Spine Surgeon, Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia – Fatmawati Hospital, Jakarta Pusat, Indonesia; 3Orthopaedic Surgeon, Consultant of Hip and Knee, Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia; 4Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok City, Indonesia; 5Consultant Dermatologist, Department of Dermatology and Venerology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia; 6Consultant Neurologist, Department of Neurology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia; 7Consultant Radiologist, Department of Radiology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia; 8Orthopaedic Spine Surgeon, Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Lambung Mangkurat, Jakarta Pusat, IndonesiaCorrespondence: Ifran Saleh, Department of Orthopaedic & Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia, Tel +62 811111221, Email ifran_ortho@yahoo.comObjective: Until now, the spondylolisthesis reduction technique has relied on posterior instrumentation using long arm pedicle screws. In this way, the segments will be brought into alignment with the other vertebrae with the pedicle mats being tightened. The aim of this study is to acknowledge whether reduction surgery for degenerative lumbar spondylolisthesis (DLS) usin

HIV-associated sensory neuropathy (HIV-SN) is a disabling complication of HIV disease and antiretroviral therapies (ART). Since stavudine was removed from recommended treatment schedules, the prevalence of HIV-SN has declined and associated risk factors have changed. With stavudine, rs1799964*C (TNF-1031) associated with HIV-SN in Caucasians and Indonesians but not in South Africans. Here, we investigate associations between HIV-SN and rs1799964*C and 12 other polymorphisms spanning TNF and seven neighboring genes (the TNF-block) in Indonesians (n = 202; 34/168 cases) and South Africans (n = 75; 29/75 cases) treated without stavudine. Haplotypes were derived using fastPHASE and haplotype networks built with PopART. There were no associations with rs1799964*C in either population. However, rs9281523*C in intron 10 of BAT1 (alternatively DDX39B) independently associated with HIV-SN in Indonesians after correcting for lower CD4 T-cell counts and >500 copies of HIV RNA/mL (model p = 0.0011, Pseudo R2 = 0.09). rs4947324*T (between NFKBIL1 and LTA) independently associated with reduced risk of HIV-SN and shared haplotype 1 (containing no minor alleles) associated with increased risk of HIV-SN after correcting for greater body weight, a history of tuberculosis and nadir CD4 T-cell counts (model: p = 0.0003, Pseudo R2 = 0.22). These results confirm TNF-block genotypes influence susceptibility of HIV-SN. However, critical genotypes differ between ethnicities and with stavudine use.