ĐURĐEVIĆ, Srđan, STOJANOVIĆ, Sanja, PANTELIĆ, Miloš, NIKOLIĆ, Dragan, NIKOLIĆ, Marijana BASTA, and KAĆANSKI, Mihaela MOCKO
Introduction. During the period from 1993 - 2013, 175 women with invasive cervical cancer underwent radical hysterectomy sec. Wertheim- Meigs at the Department of Gynecology and Obstetrics, Clinical Center of Vojvodina in Novi Sad. Indications for radical hysterectomy comprise histopathologically confirmed invasive cervical cancer in stages I B 1 - II B according to the International Federation of Gynecology and Obstetrics. Material and Methods. Stage of the disease or extent of the disease spread to the adjacent structures was assessed in accordance with the International Federation of Gynecology and Obstetrics staging system from 2009. Exclusion criteria were all other stages of this disease: I A and stages higher than II B, as well as the absence of definite histological confirmation of the cervical cancer (primary endometrial or vaginal cancer which infiltrates the uterine cervix). Prior the operation, the following had to be done: the imaging of pelvis and abdomen, chest X-ray in two directions, electrocardiography, internist and anesthesiological examination. Results. The patients' age ranged from 24-79 years (x : 46 years), and the operation duration was 120-300 minutes (x : 210 min.). Stage I B 1 was found in 64.6% of operated patients, 14.8% of the patients were in stage I B 2, 9.1% were in stage II A and 11.4% were in stage II B. Blood loss during the operation ranged from 50-800 ml (on average 300 ml), and the number of removed lymph nodes per operation was 14-75 (x : 32). Intraoperative and postoperative complications developed in 6.8% of and 17.7% of patients, respectively. Recurrence was reported in 22 (12.5%) patients, most often in paraaortic lymph nodes (3.4%) and parametria (2.8%), while the overall 5-year survival rate was 87% until 2008. Concluision. Wertheim-Meigs radical hysterectomy is a basic surgical technique for the treatment of initial stages of invasive cervical cancer. Uvod. U toku 20-godišnjeg perioda (1993â'2013.), kod 175 žena sa invazivnim karcinomom grlića materice urađena je radikalna histerektomija po metodi Verthajm-Megz na Klinici za ginekologiju i akušerstvo Kliničkog centra Vojvodine u Novom Sadu. Indikaciju za radikalnu histerektomiju predstavljala je histopatološka potvrda invazivnog karcinoma grlića materice u stadijumu IB 1-IIB prema International Federation of Gynecology and Obstetrics. Materijal i metode. Procena stadijuma i proširenosti bolesti na okolne strukture vršena je primenom sistema stadiranja International Federation of Gynecology and Obstetrics iz 2009. godine. Kriterijumi za isključivanje iz istraživanja obuhvatili su sve druge stadijume bolesti: IA i stadijume preko IIB kao i odsustvo definitivne histopatološke potvrde karcinoma grlića materice na definitivnom preparatu (primarni karcinom endometrijuma ili vagine koji je zahvatio grlić materice). Pre operacije insistirali smo na sprovođenju imidžing metoda dijagnostike karlice i abdomena, rendgenskom snimku pluća u dva pravca, elektrokardiogramu, internističkom i anesteziološkom pregledu. Rezultati. Uzrast pacijentkinja kretao se 24-79 godina (x : 46 god.), vreme trajanja operacije iznosilo je 120-300 minuta (x : 210 min.). U stadijumu IB 1 bilo je 64,6% operisanih, 14,8% u stadijumu IB 2, 9,1% u stadijumu IIA i 11,4% u stadijumu IIB. Gubitak krvi u toku operacije kretao se 50-800 ml (u proseku 300 ml), broj uklonjenih limfnih čvorova bio je 14-75 (x : 32). Zabeležili smo 6,8% intraoperativnih i 17,7% postoperativnih komplikacija. Recidiv bolesti evidentiran je kod 22 (12,5%) pacijentkinje, najčešće u paraaortalnoj grupi limfnih čvorova 3,4% i u predelu parametrijuma 2,8%, dok je ukupno petogodišnje preživljavanje iznosilo 87% do 2008. godine. Zaključak. Radikalna histerektomija po metodi Verthajm-Megz predstavlja osnovnu hiruršku tehniku u lečenju početnih stadijuma invazivnog karcinoma grlića materice. [ABSTRACT FROM AUTHOR]