Search

Your search keyword '"Obrecht D"' showing total 171 results
Start Over Author "Obrecht D"
171 results on '"Obrecht D"'

2. EPEN-36. THE TREATMENT OUTCOME OF PAEDIATRIC SUPRATENTORIAL C11ORF95-RELA FUSED EPENDYMOMA: A COMBINED REPORT FROM E-HIT SERIES AND AUSTRALIAN NEW ZEALAND CHILDREN’S HAEMATOLOGY/ONCOLOGY GROUP

Author

Ng, CH, Obrecht, D, Buntine, M, Wells, O, Campbell, MA, Bhatia, K, Sullivan, M, Williams, M, Quang, DAK, Kinross, K, White, C, Algar, E, Witt, H, Schuller, U, Mynarek, M, Pietsch, T, Gerber, NU, Benesch, M, Warmuth-Metz, M, Kortmann, R, Bison, B, Taylor, MD, Ramaswamy, V, Rutkowski, S, Pfister, SM, Jones, DTW, Gottardo, NG, Von Hoff, K, Pajtler, KW, Hansford, JR, Ng, CH, Obrecht, D, Buntine, M, Wells, O, Campbell, MA, Bhatia, K, Sullivan, M, Williams, M, Quang, DAK, Kinross, K, White, C, Algar, E, Witt, H, Schuller, U, Mynarek, M, Pietsch, T, Gerber, NU, Benesch, M, Warmuth-Metz, M, Kortmann, R, Bison, B, Taylor, MD, Ramaswamy, V, Rutkowski, S, Pfister, SM, Jones, DTW, Gottardo, NG, Von Hoff, K, Pajtler, KW, and Hansford, JR

Abstract

AIM Advances in molecular classification of paediatric ependymoma have been pivotal in improving risk stratification and understanding of this disease. C11orf95-RELA fused supratentorial ependymoma (ST-EPN) have been reported to have a poor outcome, with 10-year overall survival (OS) of 49% and progression free survival (PFS) of 19%. A cohort of patients from multiple international institutions with molecularly confirmed C11orf95-RELA fused ST-EPN were reviewed to assess their disease behaviour. METHOD: We reviewed patients with molecularly determined C11orf95-RELA supratentorial ependymoma diagnosed between 1999 – 2019. Demographic information, extent of surgical resection, use of radiotherapy and/or chemotherapy, disease recurrence, treatment at recurrence and clinical outcome data was collected. PFS and OS of all patients were estimated using Kaplan-Meier method. RESULTS A total of 76 ST-EPN patients with C11orf95-RELA fusion were identified (median age: 7 years3 months, range: 5 months – 18 years7 months). 58 patients (76.3%) had complete surgical resection. 70 patients(92.1%) received radiotherapy. 55 patients(72.3%) received chemotherapy. The 10-year OS of C11orf95-RELA fused ST-EPN was 72.4% and PFS was 63.8%. In contrast, ST-EPN at a single institution with unconfirmed molecular status had an OS of 61.1% and PFS of 34.9%. CONCLUSION Detailed molecular analysis identified distinct subgroups of patients with ST-EPN. Patients from this cohort with C11orf95-RELA methylation profiles had a significantly higher OS compared to previous reports and those with unconfirmed fusion status, emphasising the critical importance of complete molecular profiling to assist in treatment decision making. Complete molecular analysis in future prospective cohorts is essential for accurate risk stratification and treatment selection.

Published
2020

12. Properties and structure-activity studies of cyclic beta-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I

Author

Robinson, J A, Shankaramma, S C, Jetter, P, Kienzl, U, Schwendener, R, Vrijbloed, J W, Obrecht, D, University of Zurich, and Robinson, J A

Subjects
1303 Biochemistry, 1313 Molecular Medicine, 3002 Drug Discovery, 10061 Institute of Molecular Cancer Research, 1312 Molecular Biology, 3003 Pharmaceutical Science, 570 Life sciences, biology, 1308 Clinical Biochemistry, 1605 Organic Chemistry
Published
2005

14. Peptidomimetic antibiotics target outer membrane biogenesis in Pseudomonas aeruginosa

Author

Srinivas, N, Jetter, P, Ueberbacher, B J, Werneburg, M, Zerbe, K, Steinmann, J, VanderMeijden, B, Bernardini, F, Lederer, A, Dias, R L A, Misson, P E, Henze, H, Zumbrunn, J, Gombert, F O, Obrecht, D, Hunziker, P, Schauer, S, Ziegler, U, Käch, A, Eberl, L, Riedel, K, DeMarco, S J, Robinson, J A, Srinivas, N, Jetter, P, Ueberbacher, B J, Werneburg, M, Zerbe, K, Steinmann, J, VanderMeijden, B, Bernardini, F, Lederer, A, Dias, R L A, Misson, P E, Henze, H, Zumbrunn, J, Gombert, F O, Obrecht, D, Hunziker, P, Schauer, S, Ziegler, U, Käch, A, Eberl, L, Riedel, K, DeMarco, S J, and Robinson, J A

Abstract

Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We synthesized a family of peptidomimetic antibiotics, based on the antimicrobial peptide protegrin I. Several rounds of optimization gave a lead compound that was active in the nanomolar range against gram-negative Pseudomonas sp., but was largely inactive against other Gram-negative and Gram-positive bacteria. Biochemical and genetic studies showed the peptidomimetics had a non-membrane-lytic mechanism of action and identified a homologue of the ß-barrel protein LptD (Imp/OstA), which functions in outer membrane biogenesis, as a cellular target. The peptidomimetic showed potent antimicrobial activity in a mouse septicemia infection model. Drug-resistant strains of Pseudomonas are a serious health problem, so this family of antibiotics may have important therapeutic applications.

Published
2010

39. Use of a Pharmacophore Model To Discover a New Class of Influenza Endonuclease Inhibitors

Author

Parkes, K. E. B., Ermert, P., Fassler, J., Ives, J., Martin, J. A., Merrett, J. H., Obrecht, D., Williams, G., and Klumpp, K.

Abstract

Data from both our own and literature studies of the biochemistry and inhibition of influenza virus endonuclease was combined with data on the mechanism of action and the likely active site mechanism to propose a pharmacophore. The pharmacophore was used to design a novel structural class of inhibitors, some of which were found to have activities similar to that of known influenza endonuclease inhibitors and were also antiviral in cell culture.

Published
2003

40. Quantitative Determination of Resin Loading in Solid-Phase Organic Synthesis Using <SUP>13</SUP>C MAS NMR

Author

Hany, R., Rentsch, D., Dhanapal, B., and Obrecht, D.

Abstract

The use of quantitative carbon nuclear magnetic resonance spectroscopy (13C NMR) for the determination of resin loadings has been investigated. Magic angle spinning (MAS) NMR spectra have been obtained for solvent-swollen resins on a conventional 7 mm CP/MAS probe using the two pulse phase modulation (TPPM) proton decoupling sequence. Loadings of resin-bound organic compounds were evaluated via addition of tetrakis(trimethylsilyl)silane as reference or using the carbon resonances of the polymeric resin material as an internal standard. Results for several functionalized Wang and trityl resins are consistent with those obtained using well-established analytical methods. The 13C NMR method has interesting applications in the field of solid-phase organic synthesis (SPOS), since no functional group acting as a support for the attachment of a quantifiable chromophore must be available in the material of interest.

Published
2001

Catalog

Books, media, physical & digital resources
See catalog results