1,124 results on '"Obika, Satoshi"'
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2. Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation
3. In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity
4. Lantern-type G-quadruplex fluorescent sensors for detecting divalent metal ions
5. Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2′,4′-BNA/LNA with 9-(aminoethoxy)phenoxazine
6. Separation of the diastereomers of phosphorothioated siRNAs by anion-exchange chromatography under non-denaturing conditions
7. An antisense amido-bridged nucleic acid gapmer oligonucleotide targeting SRRM4 alters REST splicing and exhibits anti-tumor effects in small cell lung cancer and prostate cancer cells
8. Bridged Nucleic Acids for Therapeutic Oligonucleotides
9. Development of simple purification method for oligonucleotides synthesized using phosphoramidite for 5′-end modification as capping reagent
10. Applicability of supercritical fluid chromatography for oligonucleotide analysis: A proof-of-concept study
11. Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities
12. Retention behavior of short double-stranded oligonucleotide and its potential impurities by anion-exchange chromatography under non-denaturing conditions
13. Synthesis and biophysical properties of tetravalent PEG-conjugated antisense oligonucleotide
14. 2′-N-Alkylaminocarbonyl-2′-amino-LNA: Synthesis, duplex stability, nuclease resistance, and in vitro anti-microRNA activity
15. A novel transient receptor potential C3/C6 selective activator induces the cellular uptake of antisense oligonucleotides
16. Editorial: Nucleosides, nucleotides and nucleic acids: chemistry and biology
17. Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides
18. Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension
19. Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways
20. Bridged Nucleic Acids for Therapeutic Oligonucleotides
21. Synthesis of Coumarin-Conjugated Oligonucleotides via Knoevenagel Condensation to Prepare an Oligonucleotide Library
22. Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery
23. Synthesis and duplex-forming ability of oligonucleotides modified with 4′-C,5′-C-methylene-bridged nucleic acid (4′,5′-BNA)
24. Base-modified aptamers obtained by cell-internalization SELEX facilitate cellular uptake of an antisense oligonucleotide
25. 2′,4′-Bridged Nucleic Acids Containing Plural Heteroatoms in the Bridge Moiety
26. Amido-Bridged Nucleic Acid-Modified Antisense Oligonucleotides Targeting SYT13 to Treat Peritoneal Metastasis of Gastric Cancer
27. THF peroxide as a factor in generating desulphurised products from the solid-phase synthesis of phosphorothioate-modified oligonucleotides.
28. Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3′,4′-Tetrahydropyran-Bridged Nucleic Acid
29. Post‐Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex‐Forming Ability
30. Synthesis, Duplex-Forming Ability, and Enzymatic Stability of Oligonucleotides Modified with Amide-Linked Dinucleotides Containing a 3′,4′-Tetrahydropyran-Bridged Nucleic Acid.
31. Structures of increased duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine-bridged nucleic acids
32. Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′-methylguanidine-bridged nucleic acids
33. Novel strategy of liver cancer treatment with modified antisense oligonucleotides targeting human vasohibin‐2
34. Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility
35. Synthesis and biophysical properties of 5′-thio-2′,4′-BNA/LNA oligonucleotide
36. Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis
37. Synthesis and properties of a novel modified nucleic acid, 2′-N-methanesulfonyl-2′-amino-locked nucleic acid
38. Data from Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth
39. Figure S2 from Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth
40. Supplementary Table S1-S6 from Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth
41. Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs
42. Conformations and Dynamics of Ets-1 ETS Domain-DNA Complexes
43. 2′,4′-Bridged Nucleic Acids for Targeting Double-Stranded DNA
44. Evaluation of size-exclusion chromatography for the analysis of phosphorothioate oligonucleotides
45. Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA
46. Systematic Analysis of 2′- O -Alkyl Modified Analogs for Enzymatic Synthesis and Their Oligonucleotide Properties.
47. 2′-C,4′-C-Ethyleneoxy-Bridged 2′-Deoxyribonucleic Acids (EoDNAs) with Thymine Nucleobases: Synthesis, Duplex-Forming Ability, and Enzymatic Stability
48. A novel human muscle cell model of Duchenne muscular dystrophy created by CRISPR/Cas9 and evaluation of antisense-mediated exon skipping
49. Development of 8–17 XNAzymes that are functional in cells
50. The RFFL antisense oligonucleotides improve the function of CFTR mutants associated with cystic fibrosis.
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